ACTG1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte differentiation (GO:0030854)5.19272391
2regulation of interleukin-12 biosynthetic process (GO:0045075)5.11366705
3regulation of energy homeostasis (GO:2000505)4.83979656
4regulation of chronic inflammatory response (GO:0002676)4.62322394
5interleukin-1-mediated signaling pathway (GO:0070498)4.20185627
6CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.81789514
7T-helper cell differentiation (GO:0042093)3.81789514
8regulation of gamma-delta T cell differentiation (GO:0045586)3.79713048
9phospholipid homeostasis (GO:0055091)3.79022211
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.73241488
11negative T cell selection (GO:0043383)3.72857993
12negative thymic T cell selection (GO:0045060)3.71862660
13positive regulation of gamma-delta T cell activation (GO:0046645)3.69357334
14CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.68139620
15regulation of regulatory T cell differentiation (GO:0045589)3.56777881
16alpha-beta T cell differentiation (GO:0046632)3.51388770
17cellular response to ethanol (GO:0071361)3.47395561
18regulation of gamma-delta T cell activation (GO:0046643)3.47304130
19lymph node development (GO:0048535)3.44362878
20alpha-beta T cell differentiation involved in immune response (GO:0002293)3.41114822
21alpha-beta T cell activation involved in immune response (GO:0002287)3.41114822
22T cell differentiation involved in immune response (GO:0002292)3.41114822
23energy homeostasis (GO:0097009)3.39329342
24SMAD protein complex assembly (GO:0007183)3.35534729
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35247884
26response to interleukin-15 (GO:0070672)3.28434947
27positive regulation of heat generation (GO:0031652)3.26605031
28regulation of prostaglandin secretion (GO:0032306)3.23156696
29alpha-beta T cell activation (GO:0046631)3.21051544
30regulation of immunoglobulin secretion (GO:0051023)3.20204285
31CD4-positive, alpha-beta T cell activation (GO:0035710)3.19396166
32protoporphyrinogen IX metabolic process (GO:0046501)3.18576528
33activated T cell proliferation (GO:0050798)3.18213790
34positive thymic T cell selection (GO:0045059)3.16426698
35cellular response to interleukin-15 (GO:0071350)3.13015501
36positive T cell selection (GO:0043368)3.12882800
37proteasome assembly (GO:0043248)3.12043081
38regulation of fever generation (GO:0031620)3.11520014
39negative regulation of execution phase of apoptosis (GO:1900118)3.11015652
40negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.09034260
41regulation of B cell receptor signaling pathway (GO:0050855)3.08140748
42cobalamin metabolic process (GO:0009235)3.05994550
43histone H3-K4 trimethylation (GO:0080182)3.05905420
44somite rostral/caudal axis specification (GO:0032525)3.04386746
45positive regulation of prostaglandin secretion (GO:0032308)3.04280339
46mucosal-associated lymphoid tissue development (GO:0048537)3.03107822
47Peyers patch development (GO:0048541)3.03107822
48protein import into peroxisome matrix (GO:0016558)2.95201441
49thymic T cell selection (GO:0045061)2.88545732
50cellular response to glucose starvation (GO:0042149)2.87151064
51regulation of granulocyte differentiation (GO:0030852)2.86241680
52histone-serine phosphorylation (GO:0035404)2.84954801
53mannose metabolic process (GO:0006013)2.84438025
54rRNA catabolic process (GO:0016075)2.80966084
55regulation of isotype switching to IgG isotypes (GO:0048302)2.79893627
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78427253
57interkinetic nuclear migration (GO:0022027)2.78181352
58phospholipid dephosphorylation (GO:0046839)2.76472804
59histone H3-K36 demethylation (GO:0070544)2.76053961
60T cell selection (GO:0045058)2.75674862
61B cell receptor signaling pathway (GO:0050853)2.73953879
62homocysteine metabolic process (GO:0050667)2.71662381
63positive regulation of interleukin-12 production (GO:0032735)2.64872715
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64329788
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60034616
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57861754
67T-helper 1 type immune response (GO:0042088)2.57580728
68T cell proliferation (GO:0042098)2.57163297
69megakaryocyte development (GO:0035855)2.56574233
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53240342
71negative regulation of T-helper cell differentiation (GO:0045623)2.50388896
72negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.50388896
73endoderm formation (GO:0001706)2.48481448
74interferon-gamma production (GO:0032609)2.47896857
75negative regulation of T cell apoptotic process (GO:0070233)2.47702527
76positive regulation of interleukin-2 production (GO:0032743)2.43585550
77antigen processing and presentation of endogenous antigen (GO:0019883)2.43431557
78retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43217904
79regulation of heat generation (GO:0031650)2.43126863
80regulation of B cell differentiation (GO:0045577)2.42013226
81regulation of mitotic spindle organization (GO:0060236)2.40781626
82regulation of T cell receptor signaling pathway (GO:0050856)2.40410502
83T cell migration (GO:0072678)2.39159532
84neutrophil activation (GO:0042119)2.38939121
85protein localization to peroxisome (GO:0072662)2.37071062
86protein targeting to peroxisome (GO:0006625)2.37071062
87establishment of protein localization to peroxisome (GO:0072663)2.37071062
88peroxisomal transport (GO:0043574)2.36778647
89positive regulation of cellular response to oxidative stress (GO:1900409)2.36412206
90positive regulation of response to oxidative stress (GO:1902884)2.36412206
91positive regulation of icosanoid secretion (GO:0032305)2.35485025
92membrane protein intracellular domain proteolysis (GO:0031293)2.34969610
93positive regulation of isotype switching (GO:0045830)2.32738649
94signal peptide processing (GO:0006465)2.32316580
95phosphatidylinositol dephosphorylation (GO:0046856)2.31157409
96RNA destabilization (GO:0050779)2.30526244
97regulation of B cell proliferation (GO:0030888)2.29850743
98regulation of integrin activation (GO:0033623)2.29377799
99positive regulation of B cell proliferation (GO:0030890)2.29288723
100positive regulation of amino acid transport (GO:0051957)2.28862023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.85346623
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.10755470
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85861337
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.62848448
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.48765025
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93140500
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66096884
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63756761
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.58989624
10MYB_26560356_Chip-Seq_TH2_Human2.48051468
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38087794
12MYB_26560356_Chip-Seq_TH1_Human2.30731394
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30711224
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23911789
15VDR_23849224_ChIP-Seq_CD4+_Human2.21265268
16CIITA_25753668_ChIP-Seq_RAJI_Human2.18250954
17RUNX_20019798_ChIP-Seq_JUKART_Human2.16337202
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14303274
19GATA1_19941826_ChIP-Seq_K562_Human2.11726531
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07289883
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.05956087
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04607194
23GATA1_22025678_ChIP-Seq_K562_Human1.90426382
24MAF_26560356_Chip-Seq_TH1_Human1.87829832
25MYC_22102868_ChIP-Seq_BL_Human1.86244253
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72720728
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.70919961
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69944825
29GATA3_27048872_Chip-Seq_THYMUS_Human1.68280657
30MAF_26560356_Chip-Seq_TH2_Human1.66859657
31SPI1_23547873_ChIP-Seq_NB4_Human1.66068490
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63450621
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.63225477
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61872586
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60495244
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59678154
37UTX_26944678_Chip-Seq_JUKART_Human1.55754085
38GATA3_26560356_Chip-Seq_TH2_Human1.53194610
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51412408
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50970994
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48866605
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47832245
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.46380159
44GATA2_19941826_ChIP-Seq_K562_Human1.44147716
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.41860532
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40319108
47KDM5A_27292631_Chip-Seq_BREAST_Human1.39859655
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38490554
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.37033415
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.37028022
51FOXP3_21729870_ChIP-Seq_TREG_Human1.35135120
52VDR_24763502_ChIP-Seq_THP-1_Human1.32977276
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32882563
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30857888
55DCP1A_22483619_ChIP-Seq_HELA_Human1.25788315
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.25256297
57VDR_24787735_ChIP-Seq_THP-1_Human1.25220009
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23923780
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23806938
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23565625
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21733487
62VDR_21846776_ChIP-Seq_THP-1_Human1.21644584
63TAF15_26573619_Chip-Seq_HEK293_Human1.19215532
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18288076
65TFEB_21752829_ChIP-Seq_HELA_Human1.16807735
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16594728
67SCL_19346495_ChIP-Seq_HPC-7_Human1.15413155
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11437805
69ELK1_19687146_ChIP-ChIP_HELA_Human1.08545557
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.07803234
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07547764
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05673010
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.05630027
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04207577
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.02752731
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.02353185
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00215901
78CBP_20019798_ChIP-Seq_JUKART_Human0.98850845
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98850845
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98783793
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98490025
82GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98185566
83BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98152357
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97308697
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95610989
86CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94993221
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93186639
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92904013
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90384071
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89132697
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86971481
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86800827
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85242081
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84935138
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.83912405
96SALL1_21062744_ChIP-ChIP_HESCs_Human0.83912153
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82938018
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81833800
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80991690
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79683983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo3.48116019
2MP0002254_reproductive_system_inflammat3.34804418
3MP0000685_abnormal_immune_system3.18625769
4MP0003763_abnormal_thymus_physiology2.91677470
5MP0003436_decreased_susceptibility_to2.78706730
6MP0009840_abnormal_foam_cell2.61329311
7MP0005083_abnormal_biliary_tract2.60457606
8MP0001873_stomach_inflammation2.56378059
9MP0005671_abnormal_response_to2.46569622
10MP0005058_abnormal_lysosome_morphology2.41719704
11MP0000569_abnormal_digit_pigmentation2.33836896
12MP0001835_abnormal_antigen_presentation2.31154899
13MP0003724_increased_susceptibility_to2.23210260
14MP0002166_altered_tumor_susceptibility2.22703350
15MP0001348_abnormal_lacrimal_gland2.18230955
16MP0002009_preneoplasia2.15332503
17MP0004043_abnormal_pH_regulation2.14643677
18MP0005451_abnormal_body_composition2.13442258
19MP0001800_abnormal_humoral_immune2.09955168
20MP0002139_abnormal_hepatobiliary_system2.09048028
21MP0005310_abnormal_salivary_gland2.03116403
22MP0002138_abnormal_hepatobiliary_system2.01045350
23MP0005076_abnormal_cell_differentiation1.97803135
24MP0005000_abnormal_immune_tolerance1.96337237
25MP0002396_abnormal_hematopoietic_system1.94715060
26MP0003191_abnormal_cellular_cholesterol1.89356854
27MP0004808_abnormal_hematopoietic_stem1.89069487
28MP0002398_abnormal_bone_marrow1.88743451
29MP0001790_abnormal_immune_system1.87310435
30MP0005387_immune_system_phenotype1.87310435
31MP0002405_respiratory_system_inflammati1.82562509
32MP0002723_abnormal_immune_serum1.79758641
33MP0005379_endocrine/exocrine_gland_phen1.74169521
34MP0002419_abnormal_innate_immunity1.73210394
35MP0002420_abnormal_adaptive_immunity1.68710973
36MP0002452_abnormal_antigen_presenting1.68508192
37MP0000689_abnormal_spleen_morphology1.67689985
38MP0001819_abnormal_immune_cell1.64920913
39MP0000703_abnormal_thymus_morphology1.63204240
40MP0002722_abnormal_immune_system1.62202393
41MP0004947_skin_inflammation1.61578106
42MP0009785_altered_susceptibility_to1.61473881
43MP0005220_abnormal_exocrine_pancreas1.59806367
44MP0002933_joint_inflammation1.58170475
45MP0002163_abnormal_gland_morphology1.57236837
46MP0003786_premature_aging1.55281234
47MP0002006_tumorigenesis1.55270883
48MP0000716_abnormal_immune_system1.51638154
49MP0005025_abnormal_response_to1.49579440
50MP0002148_abnormal_hypersensitivity_rea1.43313277
51MP0009333_abnormal_splenocyte_physiolog1.41247264
52MP0002429_abnormal_blood_cell1.39601971
53MP0004147_increased_porphyrin_level1.39329825
54MP0010386_abnormal_urinary_bladder1.38159126
55MP0003172_abnormal_lysosome_physiology1.37741449
56MP0005448_abnormal_energy_balance1.31931483
57MP0001845_abnormal_inflammatory_respons1.27016185
58MP0008057_abnormal_DNA_replication1.24830505
59MP0001533_abnormal_skeleton_physiology1.18980686
60MP0004510_myositis1.14732900
61MP0010155_abnormal_intestine_physiology1.13176387
62MP0008469_abnormal_protein_level1.10256048
63MP0003303_peritoneal_inflammation1.08081461
64MP0003828_pulmonary_edema1.04884790
65MP0000427_abnormal_hair_cycle1.02674507
66MP0005174_abnormal_tail_pigmentation1.00335201
67MP0009115_abnormal_fat_cell1.00028988
68MP0002970_abnormal_white_adipose0.99864559
69MP0000015_abnormal_ear_pigmentation0.99082291
70MP0002693_abnormal_pancreas_physiology0.97579375
71MP0001545_abnormal_hematopoietic_system0.94887611
72MP0005397_hematopoietic_system_phenotyp0.94887611
73MP0000609_abnormal_liver_physiology0.92092859
74MP0004883_abnormal_blood_vessel0.90827759
75MP0003693_abnormal_embryo_hatching0.90463676
76MP0000598_abnormal_liver_morphology0.90449345
77MP0003866_abnormal_defecation0.89166814
78MP0001919_abnormal_reproductive_system0.87035776
79MP0006035_abnormal_mitochondrial_morpho0.85981648
80MP0008995_early_reproductive_senescence0.83399888
81MP0005164_abnormal_response_to0.83180371
82MP0006082_CNS_inflammation0.80687270
83MP0002060_abnormal_skin_morphology0.80602752
84MP0003252_abnormal_bile_duct0.80044954
85MP0002277_abnormal_respiratory_mucosa0.79446653
86MP0000538_abnormal_urinary_bladder0.78772772
87MP0002095_abnormal_skin_pigmentation0.78404403
88MP0005075_abnormal_melanosome_morpholog0.77724368
89MP0005464_abnormal_platelet_physiology0.76395719
90MP0004381_abnormal_hair_follicle0.76211034
91MP0005408_hypopigmentation0.74774321
92MP0004130_abnormal_muscle_cell0.74756464
93MP0000372_irregular_coat_pigmentation0.74315674
94MP0010329_abnormal_lipoprotein_level0.73523750
95MP0002136_abnormal_kidney_physiology0.72542622
96MP0000371_diluted_coat_color0.72145055
97MP0001243_abnormal_dermal_layer0.69028467
98MP0001853_heart_inflammation0.67956535
99MP0002998_abnormal_bone_remodeling0.67292117
100MP0004957_abnormal_blastocyst_morpholog0.66868116

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.42521676
2Tubulointerstitial nephritis (HP:0001970)4.74981412
3Methylmalonic aciduria (HP:0012120)4.50196881
4Increased density of long bones (HP:0006392)4.22145147
5Methylmalonic acidemia (HP:0002912)4.11607308
6Abnormality of mucopolysaccharide metabolism (HP:0011020)3.81070039
7Abnormality of polysaccharide metabolism (HP:0011012)3.81070039
8Abnormality of glycosaminoglycan metabolism (HP:0004371)3.81070039
9Mucopolysacchariduria (HP:0008155)3.79993272
10Urinary glycosaminoglycan excretion (HP:0003541)3.79993272
11Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.70232376
12T lymphocytopenia (HP:0005403)3.66790087
13Abnormality of T cell number (HP:0011839)3.60716839
14Fatigue (HP:0012378)3.53690580
15Ulnar deviation of the wrist (HP:0003049)3.26615250
16Large for gestational age (HP:0001520)3.25476989
17Upper limb muscle weakness (HP:0003484)3.12636619
18Persistence of primary teeth (HP:0006335)3.12153570
19Cervical subluxation (HP:0003308)3.11691340
20Dysostosis multiplex (HP:0000943)2.91323392
21Hematochezia (HP:0002573)2.85390398
22Rectal prolapse (HP:0002035)2.81546308
23Loss of speech (HP:0002371)2.78338135
24IgG deficiency (HP:0004315)2.73422078
25Increased CSF protein (HP:0002922)2.70796892
26Unilateral renal agenesis (HP:0000122)2.70306848
27Abnormality of vitamin B metabolism (HP:0004340)2.69096256
28Severe combined immunodeficiency (HP:0004430)2.66897078
29Ovoid vertebral bodies (HP:0003300)2.64283114
30Abnormality of the renal cortex (HP:0011035)2.63300964
31Abnormality of macrophages (HP:0004311)2.59273324
32Recurrent fungal infections (HP:0002841)2.59200558
33Abnormality of the hip-girdle musculature (HP:0001445)2.58590023
34Abnormality of the musculature of the pelvis (HP:0001469)2.58590023
35Brushfield spots (HP:0001088)2.58286261
36Premature loss of primary teeth (HP:0006323)2.55138978
37Abnormality of T cells (HP:0002843)2.53336024
38Disproportionate short-trunk short stature (HP:0003521)2.50024816
39Flared iliac wings (HP:0002869)2.49391249
40Chronic mucocutaneous candidiasis (HP:0002728)2.49229107
41Recurrent cutaneous fungal infections (HP:0011370)2.49229107
42IgA deficiency (HP:0002720)2.48819525
43Microvesicular hepatic steatosis (HP:0001414)2.47688767
44Glucose intolerance (HP:0000833)2.47576398
45Pelvic girdle muscle weakness (HP:0003749)2.42120213
46IgM deficiency (HP:0002850)2.41823835
47Spontaneous hematomas (HP:0007420)2.40780242
48Beaking of vertebral bodies (HP:0004568)2.40665244
49Autoimmune hemolytic anemia (HP:0001890)2.38842819
50Tubulointerstitial abnormality (HP:0001969)2.37449649
51Abnormality of fatty-acid metabolism (HP:0004359)2.35067588
52Anorexia (HP:0002039)2.32980927
53Stomatitis (HP:0010280)2.30348282
54Chronic diarrhea (HP:0002028)2.28704807
55Severe visual impairment (HP:0001141)2.28169020
56Poikilocytosis (HP:0004447)2.25017646
57Tubular atrophy (HP:0000092)2.24045297
58Periodontitis (HP:0000704)2.23490510
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.23146666
60Hypoalbuminemia (HP:0003073)2.18556053
61Abnormal albumin level (HP:0012116)2.18556053
62Recurrent viral infections (HP:0004429)2.17070823
63Abnormality of the vitamin B12 metabolism (HP:0004341)2.16830825
64Asymmetric septal hypertrophy (HP:0001670)2.16343021
65Abnormality of the fingertips (HP:0001211)2.14647470
66Autoimmune thrombocytopenia (HP:0001973)2.09390258
67Abnormality of T cell physiology (HP:0011840)2.08154037
68Dicarboxylic aciduria (HP:0003215)2.07739925
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07739925
70Thickened calvaria (HP:0002684)2.07681769
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05647817
72Osteomyelitis (HP:0002754)2.05132595
73Ulnar claw (HP:0001178)2.03453984
74Abnormal glucose tolerance (HP:0001952)2.03364032
75Hypoplasia of the thymus (HP:0000778)2.00295888
76Segmental peripheral demyelination/remyelination (HP:0003481)1.99516074
77Recurrent bronchitis (HP:0002837)1.97595519
78Sensorimotor neuropathy (HP:0007141)1.95702586
79Combined immunodeficiency (HP:0005387)1.94944926
80Joint swelling (HP:0001386)1.94361270
81Joint stiffness (HP:0001387)1.94272297
82Malignant hyperthermia (HP:0002047)1.91134293
83Steatorrhea (HP:0002570)1.88793043
84Abnormality of the columella (HP:0009929)1.87571913
85Severe short stature (HP:0003510)1.85948835
86Abnormality of vitamin metabolism (HP:0100508)1.84833133
87Tetraparesis (HP:0002273)1.84134629
88Attenuation of retinal blood vessels (HP:0007843)1.82964689
89Abnormality of the common coagulation pathway (HP:0010990)1.82401124
90Albinism (HP:0001022)1.81879476
91Renal cortical cysts (HP:0000803)1.80829371
92Hypoplasia of the odontoid process (HP:0003311)1.80108932
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.80051534
94Abnormality of the musculature of the hand (HP:0001421)1.77319157
95Aplasia/hypoplasia of the uterus (HP:0008684)1.77246670
96Broad face (HP:0000283)1.76805533
97Shoulder girdle muscle weakness (HP:0003547)1.75403876
98Pancreatitis (HP:0001733)1.75096150
99Spinal muscular atrophy (HP:0007269)1.70275034
100Abnormality of the intrinsic pathway (HP:0010989)1.69672752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.34816364
2TXK3.33927609
3ACVR1B3.18034086
4IRAK42.79749242
5NLK2.71863737
6BRSK22.65595439
7BRD42.59490248
8PRPF4B2.48596406
9ITK2.34052557
10CAMKK22.29140088
11CDK122.28886103
12TIE12.20199923
13MAP4K11.95430313
14TEC1.86495712
15AKT31.84073291
16BRSK11.68670079
17FES1.68206714
18MAP2K21.67219537
19IRAK21.58021286
20MAPK111.45445864
21BLK1.44667572
22MELK1.40762735
23NEK21.33699988
24BTK1.32227602
25PDK21.29996874
26MAP3K141.26931143
27PIK3CG1.23507824
28GRK61.22237808
29MAP2K31.19393016
30BMPR1B1.17541960
31TNK21.14722682
32ZAP701.14577015
33IKBKB1.12220012
34IKBKE1.11757392
35EEF2K1.09543967
36CDC42BPA1.08960646
37TRPM71.08110785
38PBK1.07779892
39TLK11.07200346
40MST41.03705644
41SYK1.01328600
42ICK1.00295132
43TYK20.98336331
44RPS6KA50.98009648
45STK100.96723909
46PIM20.95112559
47MAP3K70.94104184
48STK40.92920465
49KIT0.91617478
50TGFBR10.90952106
51RIPK40.89336957
52TAOK20.85053864
53FGFR30.85047024
54CHUK0.85026716
55MAP2K60.84993139
56PIM10.84080818
57JAK30.82301483
58LCK0.80439417
59BUB10.79663005
60BMPR20.79547030
61FGFR40.79294192
62STK110.77487173
63PRKCQ0.77348038
64CDK40.77111574
65JAK10.72497431
66CDK80.69925708
67EIF2AK30.69807111
68TBK10.69744331
69SGK20.68054349
70HCK0.65850849
71MARK30.65533462
72LYN0.64674862
73MKNK10.64416222
74RPS6KA40.63421426
75NEK60.62965067
76VRK10.62861089
77SIK30.61960411
78MAP3K130.60623334
79ERBB30.59521090
80STK30.58469256
81TGFBR20.58196529
82TESK20.56781665
83MAP2K10.55703196
84TSSK60.54699173
85SGK30.51960066
86MTOR0.51473133
87FRK0.48893396
88MAPK10.45576061
89TRIB30.45108022
90MAP3K100.45001536
91TAOK30.44379508
92WNK10.43983845
93CSK0.43840501
94MAPK30.43101493
95JAK20.42798627
96CLK10.41001536
97CAMK1D0.39452830
98MAPK80.39356831
99CAMKK10.38451334
100SGK2230.37016390

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.56887761
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.41111156
3Other glycan degradation_Homo sapiens_hsa005113.36625498
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.12763721
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.53269739
6Circadian rhythm_Homo sapiens_hsa047102.26507803
7Primary immunodeficiency_Homo sapiens_hsa053402.20442575
8Regulation of autophagy_Homo sapiens_hsa041402.18277861
9Autoimmune thyroid disease_Homo sapiens_hsa053202.18091391
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12653281
11Hematopoietic cell lineage_Homo sapiens_hsa046402.03771912
12Allograft rejection_Homo sapiens_hsa053302.00317022
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95161050
14Measles_Homo sapiens_hsa051621.93014762
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90083988
16T cell receptor signaling pathway_Homo sapiens_hsa046601.81243853
17Leishmaniasis_Homo sapiens_hsa051401.68040838
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59110592
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.57439372
20Osteoclast differentiation_Homo sapiens_hsa043801.51038878
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41931247
22Rheumatoid arthritis_Homo sapiens_hsa053231.40158682
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40003249
24Lysosome_Homo sapiens_hsa041421.38885934
25Asthma_Homo sapiens_hsa053101.37639549
26TNF signaling pathway_Homo sapiens_hsa046681.24253250
27ABC transporters_Homo sapiens_hsa020101.22808993
28Influenza A_Homo sapiens_hsa051641.20337437
29Graft-versus-host disease_Homo sapiens_hsa053321.20222512
30FoxO signaling pathway_Homo sapiens_hsa040681.18484468
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15897726
32Toxoplasmosis_Homo sapiens_hsa051451.14392836
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13602851
34Peroxisome_Homo sapiens_hsa041461.12683673
35One carbon pool by folate_Homo sapiens_hsa006701.11509813
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10515841
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.06367978
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05347199
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01277450
40Protein export_Homo sapiens_hsa030601.01119124
41Hepatitis B_Homo sapiens_hsa051610.99307068
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99148512
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98978897
44Type I diabetes mellitus_Homo sapiens_hsa049400.98400545
45B cell receptor signaling pathway_Homo sapiens_hsa046620.95813154
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93788343
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93532531
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93246444
49Inositol phosphate metabolism_Homo sapiens_hsa005620.92266583
50Herpes simplex infection_Homo sapiens_hsa051680.90219529
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89258075
52Acute myeloid leukemia_Homo sapiens_hsa052210.88631639
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87857551
54Antigen processing and presentation_Homo sapiens_hsa046120.86511111
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86290083
56RNA degradation_Homo sapiens_hsa030180.86010755
57Apoptosis_Homo sapiens_hsa042100.83808675
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82947680
59Systemic lupus erythematosus_Homo sapiens_hsa053220.82937459
60Epstein-Barr virus infection_Homo sapiens_hsa051690.80167855
61Sulfur metabolism_Homo sapiens_hsa009200.77005940
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76337715
63HTLV-I infection_Homo sapiens_hsa051660.75882880
64Malaria_Homo sapiens_hsa051440.75235592
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73171334
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71908877
67Viral carcinogenesis_Homo sapiens_hsa052030.69727182
68Prolactin signaling pathway_Homo sapiens_hsa049170.67936921
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67499509
70Tuberculosis_Homo sapiens_hsa051520.66465058
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66399327
72Chronic myeloid leukemia_Homo sapiens_hsa052200.65983489
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65668278
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64416714
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62966450
76Cell cycle_Homo sapiens_hsa041100.60220422
77Hepatitis C_Homo sapiens_hsa051600.59647833
78TGF-beta signaling pathway_Homo sapiens_hsa043500.57440685
79HIF-1 signaling pathway_Homo sapiens_hsa040660.54050853
80Insulin resistance_Homo sapiens_hsa049310.50275343
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49878441
82mTOR signaling pathway_Homo sapiens_hsa041500.49686118
83Fanconi anemia pathway_Homo sapiens_hsa034600.49599206
84Type II diabetes mellitus_Homo sapiens_hsa049300.48830381
85Tryptophan metabolism_Homo sapiens_hsa003800.48172362
86Chemokine signaling pathway_Homo sapiens_hsa040620.47476945
87Propanoate metabolism_Homo sapiens_hsa006400.46387141
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45795837
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.44413445
90Legionellosis_Homo sapiens_hsa051340.43629372
91Sphingolipid metabolism_Homo sapiens_hsa006000.42477598
92Small cell lung cancer_Homo sapiens_hsa052220.42086864
93African trypanosomiasis_Homo sapiens_hsa051430.41771964
94Staphylococcus aureus infection_Homo sapiens_hsa051500.39325097
95Steroid biosynthesis_Homo sapiens_hsa001000.36166279
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34964319
97Pancreatic cancer_Homo sapiens_hsa052120.33882201
98Non-small cell lung cancer_Homo sapiens_hsa052230.33625005
99Colorectal cancer_Homo sapiens_hsa052100.33133453
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32325884

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