ACTG1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1preassembly of GPI anchor in ER membrane (GO:0016254)6.12601535
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.23859800
3ATP synthesis coupled proton transport (GO:0015986)5.23859800
4DNA deamination (GO:0045006)4.89044921
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.65741048
6mannosylation (GO:0097502)4.60725561
7GPI anchor metabolic process (GO:0006505)4.23679602
8C-terminal protein amino acid modification (GO:0018410)4.23289535
9GPI anchor biosynthetic process (GO:0006506)4.13818340
10C-terminal protein lipidation (GO:0006501)4.00761331
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.96334225
12xenobiotic catabolic process (GO:0042178)3.90982102
13water-soluble vitamin biosynthetic process (GO:0042364)3.89658511
14signal transduction involved in cell cycle checkpoint (GO:0072395)3.85763505
15regulation of cellular amino acid metabolic process (GO:0006521)3.75570648
16cullin deneddylation (GO:0010388)3.71308205
17iron-sulfur cluster assembly (GO:0016226)3.70414018
18metallo-sulfur cluster assembly (GO:0031163)3.70414018
19positive regulation of prostaglandin secretion (GO:0032308)3.69590781
20signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63491787
21signal transduction involved in DNA damage checkpoint (GO:0072422)3.63491787
22meiotic chromosome segregation (GO:0045132)3.63344599
23detection of light stimulus involved in visual perception (GO:0050908)3.58203920
24detection of light stimulus involved in sensory perception (GO:0050962)3.58203920
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56741420
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56741420
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56741420
28GTP biosynthetic process (GO:0006183)3.56622467
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.55574405
30negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.48512961
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45812554
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45812554
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41477394
34protein complex biogenesis (GO:0070271)3.40839522
35proteasome assembly (GO:0043248)3.38250014
36endothelial tube morphogenesis (GO:0061154)3.32858384
37morphogenesis of an endothelium (GO:0003159)3.32858384
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27043626
39DNA replication-dependent nucleosome assembly (GO:0006335)3.26878379
40DNA replication-dependent nucleosome organization (GO:0034723)3.26878379
41glial cell proliferation (GO:0014009)3.26753032
42regulation of prostaglandin secretion (GO:0032306)3.24277117
43mitochondrial respiratory chain complex assembly (GO:0033108)3.18813871
44protein neddylation (GO:0045116)3.18151186
45NIK/NF-kappaB signaling (GO:0038061)3.14940746
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.12510701
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11897449
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06004751
49establishment of viral latency (GO:0019043)3.02425933
50UTP biosynthetic process (GO:0006228)3.01218035
51somite development (GO:0061053)3.00775133
52ATP biosynthetic process (GO:0006754)2.97773760
53behavioral response to ethanol (GO:0048149)2.97215480
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96821276
55energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.96775020
56ATP hydrolysis coupled proton transport (GO:0015991)2.96775020
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94851138
58respiratory electron transport chain (GO:0022904)2.92663235
59regulation of transmission of nerve impulse (GO:0051969)2.92419945
60establishment of integrated proviral latency (GO:0075713)2.92404401
61electron transport chain (GO:0022900)2.90765730
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90076655
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.90076655
64NADH dehydrogenase complex assembly (GO:0010257)2.90076655
65protein deneddylation (GO:0000338)2.89902944
66indolalkylamine metabolic process (GO:0006586)2.89152036
67pentose metabolic process (GO:0019321)2.88002332
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87957063
69negative regulation of ligase activity (GO:0051352)2.87957063
70protein localization to cilium (GO:0061512)2.86267754
71regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.84080073
72regulation of RIG-I signaling pathway (GO:0039535)2.81565181
73mitotic cell cycle arrest (GO:0071850)2.81054406
74mismatch repair (GO:0006298)2.80075121
75retina homeostasis (GO:0001895)2.80016307
76guanosine-containing compound biosynthetic process (GO:1901070)2.78725061
77positive regulation of ligase activity (GO:0051351)2.77748372
78cornea development in camera-type eye (GO:0061303)2.77519285
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76151304
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.75490471
81termination of RNA polymerase III transcription (GO:0006386)2.75490471
82hydrogen ion transmembrane transport (GO:1902600)2.74839209
83UTP metabolic process (GO:0046051)2.74611949
84glycolipid biosynthetic process (GO:0009247)2.74554473
85DNA ligation (GO:0006266)2.73933878
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71587756
87neuronal action potential (GO:0019228)2.71221851
88ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68059036
89DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.67816244
90respiratory chain complex IV assembly (GO:0008535)2.67762740
91regulation of cellular amine metabolic process (GO:0033238)2.63858000
92limb bud formation (GO:0060174)2.63852665
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62675584
94DNA catabolic process, exonucleolytic (GO:0000738)2.62146093
95hydrogen transport (GO:0006818)2.61655653
96proton transport (GO:0015992)2.61271784
97replicative senescence (GO:0090399)2.61117695
98vitamin biosynthetic process (GO:0009110)2.61013489
99sequestering of actin monomers (GO:0042989)2.60993028
100fat-soluble vitamin catabolic process (GO:0042363)2.59637493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.12142274
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.04384545
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97028127
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.48479443
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10284047
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.97089170
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96585347
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78729857
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71622308
10ZNF274_21170338_ChIP-Seq_K562_Hela2.64609228
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.58648286
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.54656492
13YY1_21170310_ChIP-Seq_MESCs_Mouse2.54327399
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47661822
15VDR_23849224_ChIP-Seq_CD4+_Human2.37535245
16ELK1_19687146_ChIP-ChIP_HELA_Human2.36847696
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32735230
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29365814
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.04109508
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.02679365
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89205704
22VDR_22108803_ChIP-Seq_LS180_Human1.86913704
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82850767
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77491163
25MYC_18940864_ChIP-ChIP_HL60_Human1.74440009
26FOXP3_21729870_ChIP-Seq_TREG_Human1.72392682
27CIITA_25753668_ChIP-Seq_RAJI_Human1.70359333
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60665260
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.60112940
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.54067982
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50703358
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50100587
33TAF15_26573619_Chip-Seq_HEK293_Human1.50057996
34PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.49178242
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46342562
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42427073
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38562058
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37495182
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36940473
40XRN2_22483619_ChIP-Seq_HELA_Human1.33531530
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32134005
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28873208
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28202063
44TP53_22573176_ChIP-Seq_HFKS_Human1.25797104
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25372489
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24015865
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.22249496
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19464743
49EWS_26573619_Chip-Seq_HEK293_Human1.17984115
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17956115
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.16427615
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15679017
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12808631
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12486868
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11727504
56GBX2_23144817_ChIP-Seq_PC3_Human1.09365391
57GABP_19822575_ChIP-Seq_HepG2_Human1.08814470
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07838592
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07769270
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07613147
61NCOR_22424771_ChIP-Seq_293T_Human1.06950058
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.05985814
63IRF1_19129219_ChIP-ChIP_H3396_Human1.04663300
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04089904
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03855644
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03688003
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03157085
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99908885
69PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99839887
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98782967
71FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97904667
72FOXA1_25329375_ChIP-Seq_VCAP_Human0.97904667
73CBP_20019798_ChIP-Seq_JUKART_Human0.95556561
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95556561
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95357803
76EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94936657
77IGF1R_20145208_ChIP-Seq_DFB_Human0.93495487
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93274376
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92599363
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.91600214
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90789521
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90035224
83MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89870678
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89377085
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88353121
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87582985
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87190273
88GATA3_26560356_Chip-Seq_TH2_Human0.85524982
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85258807
90OCT4_20526341_ChIP-Seq_ESCs_Human0.84950141
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84581936
92AR_20517297_ChIP-Seq_VCAP_Human0.83750034
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.83082809
94TAF2_19829295_ChIP-Seq_ESCs_Human0.81666310
95MYC_18555785_ChIP-Seq_MESCs_Mouse0.81329005
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81214014
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80041005
98P300_19829295_ChIP-Seq_ESCs_Human0.80023290
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.79839521
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79495195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.40120552
2MP0001968_abnormal_touch/_nociception3.18731467
3MP0002102_abnormal_ear_morphology3.15635507
4MP0003195_calcinosis3.02370201
5MP0005084_abnormal_gallbladder_morpholo2.80142832
6MP0005360_urolithiasis2.65320053
7MP0008875_abnormal_xenobiotic_pharmacok2.61067287
8MP0003718_maternal_effect2.53517307
9MP0006276_abnormal_autonomic_nervous2.52924627
10MP0008872_abnormal_physiological_respon2.47719223
11MP0003646_muscle_fatigue2.33597578
12MP0001984_abnormal_olfaction2.33539621
13MP0008058_abnormal_DNA_repair2.24372606
14MP0010094_abnormal_chromosome_stability2.19939377
15MP0006072_abnormal_retinal_apoptosis2.08784987
16MP0002166_altered_tumor_susceptibility2.04704430
17MP0003786_premature_aging1.92789593
18MP0002006_tumorigenesis1.87041479
19MP0002653_abnormal_ependyma_morphology1.80295934
20MP0005671_abnormal_response_to1.78267927
21MP0003880_abnormal_central_pattern1.76319287
22MP0000372_irregular_coat_pigmentation1.75322815
23MP0005551_abnormal_eye_electrophysiolog1.68271819
24MP0003011_delayed_dark_adaptation1.67865322
25MP0008260_abnormal_autophagy1.62331639
26MP0005645_abnormal_hypothalamus_physiol1.58587873
27MP0001970_abnormal_pain_threshold1.56366120
28MP0005646_abnormal_pituitary_gland1.55430976
29MP0001919_abnormal_reproductive_system1.51889398
30MP0009764_decreased_sensitivity_to1.50802513
31MP0005083_abnormal_biliary_tract1.49074592
32MP0005085_abnormal_gallbladder_physiolo1.47163726
33MP0008877_abnormal_DNA_methylation1.45021842
34MP0002938_white_spotting1.41249628
35MP0005253_abnormal_eye_physiology1.41054654
36MP0003122_maternal_imprinting1.39662529
37MP0003724_increased_susceptibility_to1.39229468
38MP0002733_abnormal_thermal_nociception1.37924978
39MP0002909_abnormal_adrenal_gland1.37222664
40MP0005377_hearing/vestibular/ear_phenot1.36223658
41MP0003878_abnormal_ear_physiology1.36223658
42MP0000465_gastrointestinal_hemorrhage1.35343821
43MP0002822_catalepsy1.34887898
44MP0002734_abnormal_mechanical_nocicepti1.31831280
45MP0001501_abnormal_sleep_pattern1.29137142
46MP0003567_abnormal_fetal_cardiomyocyte1.28158975
47MP0005423_abnormal_somatic_nervous1.25973976
48MP0006054_spinal_hemorrhage1.23422277
49MP0003137_abnormal_impulse_conducting1.23096369
50MP0002272_abnormal_nervous_system1.23030104
51MP0002139_abnormal_hepatobiliary_system1.20540935
52MP0002009_preneoplasia1.14393757
53MP0006292_abnormal_olfactory_placode1.14305754
54MP0000647_abnormal_sebaceous_gland1.13766413
55MP0000631_abnormal_neuroendocrine_gland1.11809089
56MP0002064_seizures1.08885379
57MP0004145_abnormal_muscle_electrophysio1.07001826
58MP0001502_abnormal_circadian_rhythm1.05351371
59MP0010234_abnormal_vibrissa_follicle1.04160068
60MP0001905_abnormal_dopamine_level1.03642241
61MP0008995_early_reproductive_senescence1.02861012
62MP0001764_abnormal_homeostasis1.02858030
63MP0006036_abnormal_mitochondrial_physio1.00430107
64MP0002751_abnormal_autonomic_nervous1.00138898
65MP0006035_abnormal_mitochondrial_morpho0.99639430
66MP0009745_abnormal_behavioral_response0.98975111
67MP0005389_reproductive_system_phenotype0.98101014
68MP0004270_analgesia0.96074260
69MP0009046_muscle_twitch0.90329224
70MP0002572_abnormal_emotion/affect_behav0.82502160
71MP0005410_abnormal_fertilization0.81916746
72MP0003252_abnormal_bile_duct0.81342474
73MP0001529_abnormal_vocalization0.81138246
74MP0003191_abnormal_cellular_cholesterol0.81015251
75MP0004742_abnormal_vestibular_system0.80652774
76MP0001800_abnormal_humoral_immune0.80257542
77MP0001986_abnormal_taste_sensitivity0.79418506
78MP0004019_abnormal_vitamin_homeostasis0.79181551
79MP0001835_abnormal_antigen_presentation0.78799266
80MP0002876_abnormal_thyroid_physiology0.78513839
81MP0003121_genomic_imprinting0.77908635
82MP0001727_abnormal_embryo_implantation0.75521815
83MP0000685_abnormal_immune_system0.74694818
84MP0002735_abnormal_chemical_nociception0.74123920
85MP0002557_abnormal_social/conspecific_i0.73864418
86MP0002282_abnormal_trachea_morphology0.71283804
87MP0004147_increased_porphyrin_level0.70603514
88MP0001929_abnormal_gametogenesis0.69376970
89MP0008775_abnormal_heart_ventricle0.68600403
90MP0005365_abnormal_bile_salt0.68105852
91MP0003186_abnormal_redox_activity0.67899292
92MP0004215_abnormal_myocardial_fiber0.67462967
93MP0003111_abnormal_nucleus_morphology0.66580930
94MP0005332_abnormal_amino_acid0.64856058
95MP0003787_abnormal_imprinting0.64601669
96MP0004142_abnormal_muscle_tone0.64288041
97MP0002928_abnormal_bile_duct0.62506742
98MP0004924_abnormal_behavior0.62181490
99MP0005386_behavior/neurological_phenoty0.62181490
100MP0005195_abnormal_posterior_eye0.61317840

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)4.86450067
2Lipid accumulation in hepatocytes (HP:0006561)4.51288779
3Increased hepatocellular lipid droplets (HP:0006565)4.43838143
4Mitochondrial inheritance (HP:0001427)3.85092477
5Increased CSF lactate (HP:0002490)3.82729365
6Hepatic necrosis (HP:0002605)3.78818259
7Renal Fanconi syndrome (HP:0001994)3.72009288
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.62665244
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.62665244
10Hepatocellular necrosis (HP:0001404)3.40401604
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.38792094
12Increased intramyocellular lipid droplets (HP:0012240)3.38589322
13Acute necrotizing encephalopathy (HP:0006965)3.32755267
14Abnormal mitochondria in muscle tissue (HP:0008316)3.16085890
15Increased muscle lipid content (HP:0009058)3.07350064
16Abnormality of urine glucose concentration (HP:0011016)3.07139222
17Glycosuria (HP:0003076)3.07139222
18Increased serum lactate (HP:0002151)3.06028050
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.99947955
20Exertional dyspnea (HP:0002875)2.92211806
21Elevated erythrocyte sedimentation rate (HP:0003565)2.91858207
22Congenital stationary night blindness (HP:0007642)2.78348581
23Leukodystrophy (HP:0002415)2.76735896
24Abnormality of the anterior horn cell (HP:0006802)2.75527649
25Degeneration of anterior horn cells (HP:0002398)2.75527649
26Progressive microcephaly (HP:0000253)2.75083242
27Severe combined immunodeficiency (HP:0004430)2.72850535
28Dysautonomia (HP:0002459)2.72447784
29Acute encephalopathy (HP:0006846)2.69720927
30Renal cortical cysts (HP:0000803)2.69158254
31Progressive macrocephaly (HP:0004481)2.69145822
32Abnormality of macular pigmentation (HP:0008002)2.66142564
33Decreased electroretinogram (ERG) amplitude (HP:0000654)2.56568771
34Abolished electroretinogram (ERG) (HP:0000550)2.55495092
35Nausea (HP:0002018)2.50848098
36Poor head control (HP:0002421)2.50783672
37Lactic acidosis (HP:0003128)2.49805024
38Methylmalonic acidemia (HP:0002912)2.37655602
39Attenuation of retinal blood vessels (HP:0007843)2.36178478
40Increased serum pyruvate (HP:0003542)2.35298493
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34251145
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33376670
43Abnormality of alanine metabolism (HP:0010916)2.33376670
44Hyperalaninemia (HP:0003348)2.33376670
45Amniotic constriction ring (HP:0009775)2.30287356
46Abnormality of placental membranes (HP:0011409)2.30287356
47Abnormality of the renal cortex (HP:0011035)2.29202443
48Hypoplastic pelvis (HP:0008839)2.26469682
49IgG deficiency (HP:0004315)2.25632111
50Oral leukoplakia (HP:0002745)2.24493420
51Respiratory difficulties (HP:0002880)2.17051292
52Constricted visual fields (HP:0001133)2.13774940
53Hypoglycemic coma (HP:0001325)2.13188452
54Cerebral edema (HP:0002181)2.12720872
55Parakeratosis (HP:0001036)2.11652974
56Methylmalonic aciduria (HP:0012120)2.11244611
57Respiratory failure (HP:0002878)2.10128217
58Exercise intolerance (HP:0003546)2.08992135
59Decreased central vision (HP:0007663)2.07495567
60Inability to walk (HP:0002540)2.07381127
61Pancreatic cysts (HP:0001737)2.05358772
62Glucose intolerance (HP:0000833)2.04563749
63Abnormality of glycolysis (HP:0004366)2.02511264
64Combined immunodeficiency (HP:0005387)2.02335432
65Spastic paraparesis (HP:0002313)2.00811380
66Adrenal hypoplasia (HP:0000835)2.00462064
67Poor suck (HP:0002033)1.99349948
68Intellectual disability, profound (HP:0002187)1.99167686
69Optic disc pallor (HP:0000543)1.99064835
70Abnormality of renal resorption (HP:0011038)1.98685234
71Abnormality of cochlea (HP:0000375)1.97764179
72Thyroiditis (HP:0100646)1.95539765
73Abnormality of serum amino acid levels (HP:0003112)1.93092270
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86400206
75Atrophy/Degeneration involving motor neurons (HP:0007373)1.84690800
76Colon cancer (HP:0003003)1.84258547
77Abnormality of midbrain morphology (HP:0002418)1.83314634
78Molar tooth sign on MRI (HP:0002419)1.83314634
79Abnormality of fatty-acid metabolism (HP:0004359)1.81607857
80Erythroderma (HP:0001019)1.81445050
81Dicarboxylic aciduria (HP:0003215)1.80954912
82Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80954912
83Hyperphosphaturia (HP:0003109)1.80391350
84Lethargy (HP:0001254)1.78818558
85Progressive inability to walk (HP:0002505)1.76103297
86True hermaphroditism (HP:0010459)1.75554656
87Failure to thrive in infancy (HP:0001531)1.75323948
88CNS demyelination (HP:0007305)1.74163565
89Pachygyria (HP:0001302)1.72203054
90Myositis (HP:0100614)1.71739221
91X-linked dominant inheritance (HP:0001423)1.70150503
92Facial diplegia (HP:0001349)1.69941105
93Epiphyseal stippling (HP:0010655)1.69290480
94Limb dystonia (HP:0002451)1.69177553
95Large eyes (HP:0001090)1.68848594
96Muscular hypotonia of the trunk (HP:0008936)1.68436467
97Tinnitus (HP:0000360)1.66065514
98Hypoproteinemia (HP:0003075)1.65714796
99Limb-girdle muscle atrophy (HP:0003797)1.65437193
100Bony spicule pigmentary retinopathy (HP:0007737)1.65065317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.66356969
2TLK14.14323183
3VRK24.09312196
4VRK13.47424333
5MAP2K72.24734639
6WNK32.23952943
7NUAK12.14439305
8MAP3K42.11870803
9CCNB11.89511935
10TRIM281.80732840
11BUB11.80375048
12CSNK1G31.56118294
13TAF11.52121894
14TXK1.49709373
15ADRBK21.49700931
16TESK21.47643688
17PDK21.46366014
18SMG11.40097788
19MST41.39349761
20GRK11.39259504
21PLK21.36667717
22CSNK1A1L1.36527534
23KDR1.34344047
24TAOK31.31620379
25WNK41.25248499
26EIF2AK31.25161812
27MAPK131.24652387
28TSSK61.24436925
29DAPK31.22911205
30ERBB31.22469091
31MAP4K21.19663231
32RPS6KA51.17528508
33BLK1.16752258
34STK391.14012251
35CSNK1G21.13222790
36CSNK1G11.12932318
37BCR1.11709139
38DAPK11.11681382
39CASK1.08595146
40PBK1.08561749
41AURKA1.06486080
42PLK31.05970940
43DYRK21.01549632
44BCKDK0.96529351
45STK160.94193809
46LIMK10.93077128
47UHMK10.88688070
48NME10.83457544
49GRK60.80958688
50CDK90.80668849
51MAP2K20.77338670
52EPHA40.75409135
53NEK10.74829192
54CHEK20.74714446
55FRK0.69864782
56ATR0.69435071
57MAPKAPK50.65924066
58INSRR0.65789759
59PIK3CG0.65715528
60MAP2K60.64233659
61CDK60.64082765
62MYLK0.63873392
63AURKB0.62777615
64BMPR1B0.61003553
65OXSR10.59655569
66PLK40.59403455
67MARK10.58615205
68TESK10.57405850
69MAP3K120.57390373
70GRK50.56123257
71SYK0.55121253
72DAPK20.50400304
73PKN10.49413813
74ITK0.48800288
75MAPKAPK30.48733463
76PIM10.48633653
77PAK30.48300964
78PRKCQ0.48290836
79PRKCG0.47323089
80CDK40.44121321
81EIF2AK20.44059573
82PRKAA10.43228008
83LYN0.42145533
84OBSCN0.41475729
85IKBKB0.41242617
86MAP3K140.40657769
87PAK60.38297437
88CDK180.38232317
89CSNK2A10.37704639
90CAMK2A0.33838837
91MAP4K10.33597651
92DYRK1B0.33465566
93CDK140.33449634
94PINK10.31912364
95MAPK150.31860521
96DYRK30.31359377
97CDK150.31005451
98CSNK2A20.28226899
99PRKCE0.28133843
100PRKCA0.27916424

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.40735065
2Proteasome_Homo sapiens_hsa030504.10661384
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.84162976
4Oxidative phosphorylation_Homo sapiens_hsa001903.11605280
5Alcoholism_Homo sapiens_hsa050342.88601641
6Steroid biosynthesis_Homo sapiens_hsa001002.73128403
7Parkinsons disease_Homo sapiens_hsa050122.53998230
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21844888
9DNA replication_Homo sapiens_hsa030302.07109145
10Non-homologous end-joining_Homo sapiens_hsa034502.05677820
11Collecting duct acid secretion_Homo sapiens_hsa049661.81443616
12RNA polymerase_Homo sapiens_hsa030201.79547855
13Protein export_Homo sapiens_hsa030601.75295559
14Basal transcription factors_Homo sapiens_hsa030221.67457263
15Sulfur metabolism_Homo sapiens_hsa009201.66273510
16Mismatch repair_Homo sapiens_hsa034301.66223192
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63988431
18Nitrogen metabolism_Homo sapiens_hsa009101.62118000
19Huntingtons disease_Homo sapiens_hsa050161.58028072
20Alzheimers disease_Homo sapiens_hsa050101.51783141
21Homologous recombination_Homo sapiens_hsa034401.49549312
22Tryptophan metabolism_Homo sapiens_hsa003801.48876202
23Primary immunodeficiency_Homo sapiens_hsa053401.39657080
24Phototransduction_Homo sapiens_hsa047441.30698481
25Fatty acid elongation_Homo sapiens_hsa000621.30150645
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28910804
27Sulfur relay system_Homo sapiens_hsa041221.16910040
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15859674
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14916168
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11002049
31Vibrio cholerae infection_Homo sapiens_hsa051101.08538225
32Nucleotide excision repair_Homo sapiens_hsa034201.05785302
33Caffeine metabolism_Homo sapiens_hsa002321.03134259
34Asthma_Homo sapiens_hsa053101.03099159
35Glutathione metabolism_Homo sapiens_hsa004801.01583347
36Fanconi anemia pathway_Homo sapiens_hsa034601.01511254
37Viral carcinogenesis_Homo sapiens_hsa052031.00270896
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00023719
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98126366
40Chemical carcinogenesis_Homo sapiens_hsa052040.97629533
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96110344
42Butanoate metabolism_Homo sapiens_hsa006500.96021375
43Spliceosome_Homo sapiens_hsa030400.94737603
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.92629814
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91776778
46Propanoate metabolism_Homo sapiens_hsa006400.91600051
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91320908
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90605165
49Pyruvate metabolism_Homo sapiens_hsa006200.88867516
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88700988
51RNA transport_Homo sapiens_hsa030130.88542346
52Pyrimidine metabolism_Homo sapiens_hsa002400.86741564
53Base excision repair_Homo sapiens_hsa034100.84566634
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82420248
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82000493
56Cardiac muscle contraction_Homo sapiens_hsa042600.79910617
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79434423
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78069285
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76996102
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76883126
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75505678
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74163926
63Selenocompound metabolism_Homo sapiens_hsa004500.73829355
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.70392597
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.69232292
66Purine metabolism_Homo sapiens_hsa002300.68134152
67Fatty acid metabolism_Homo sapiens_hsa012120.67478747
68Fatty acid degradation_Homo sapiens_hsa000710.67329613
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67274900
70Synaptic vesicle cycle_Homo sapiens_hsa047210.64597434
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.64242613
72Peroxisome_Homo sapiens_hsa041460.64194958
73Fatty acid biosynthesis_Homo sapiens_hsa000610.63926581
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63426503
75Metabolic pathways_Homo sapiens_hsa011000.63318101
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.61038828
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60750546
78Antigen processing and presentation_Homo sapiens_hsa046120.60578730
79Arachidonic acid metabolism_Homo sapiens_hsa005900.60454512
80Linoleic acid metabolism_Homo sapiens_hsa005910.59602048
81Olfactory transduction_Homo sapiens_hsa047400.57752456
82Rheumatoid arthritis_Homo sapiens_hsa053230.55123829
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.51851248
84RNA degradation_Homo sapiens_hsa030180.51704613
85Ether lipid metabolism_Homo sapiens_hsa005650.48771133
86One carbon pool by folate_Homo sapiens_hsa006700.48256792
87Fat digestion and absorption_Homo sapiens_hsa049750.48118841
88Regulation of autophagy_Homo sapiens_hsa041400.45474079
89Arginine and proline metabolism_Homo sapiens_hsa003300.44521643
90Starch and sucrose metabolism_Homo sapiens_hsa005000.42295666
91beta-Alanine metabolism_Homo sapiens_hsa004100.41532879
92Carbon metabolism_Homo sapiens_hsa012000.37892711
93Allograft rejection_Homo sapiens_hsa053300.36950373
94Autoimmune thyroid disease_Homo sapiens_hsa053200.36686997
95Vitamin digestion and absorption_Homo sapiens_hsa049770.33851941
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33291137
97Taste transduction_Homo sapiens_hsa047420.30776110
98Ribosome_Homo sapiens_hsa030100.30763508
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29253566
100Histidine metabolism_Homo sapiens_hsa003400.28482090

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