ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.79371628
2	platelet dense granule organization (GO:0060155)	4.10745710
3	DNA deamination (GO:0045006)	4.08942834
4	protein complex biogenesis (GO:0070271)	4.04234910
5	L-fucose catabolic process (GO:0042355)	3.90821348
6	fucose catabolic process (GO:0019317)	3.90821348
7	L-fucose metabolic process (GO:0042354)	3.90821348
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.79038926
9	NADH dehydrogenase complex assembly (GO:0010257)	3.79038926
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.79038926
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.73446492
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66829039
13	response to pheromone (GO:0019236)	3.59928737
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.42334136
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.42334136
16	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.37171103
17	mannosylation (GO:0097502)	3.36344354
18	preassembly of GPI anchor in ER membrane (GO:0016254)	3.34035828
19	respiratory chain complex IV assembly (GO:0008535)	3.32609235
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.30966150
21	ATP synthesis coupled proton transport (GO:0015986)	3.27360110
22	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.27360110
23	protein neddylation (GO:0045116)	3.25717119
24	dopamine transport (GO:0015872)	3.25163893
25	indolalkylamine metabolic process (GO:0006586)	3.22847344
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19323864
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.19110675
28	detection of light stimulus involved in visual perception (GO:0050908)	3.19110675
29	negative regulation of mast cell activation (GO:0033004)	3.13965289
30	cytochrome complex assembly (GO:0017004)	3.11746108
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.11658982
32	piRNA metabolic process (GO:0034587)	3.08207975
33	neural tube formation (GO:0001841)	3.06582496
34	protein-cofactor linkage (GO:0018065)	3.05211772
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.00273856
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.00269700
37	amino acid salvage (GO:0043102)	3.00007703
38	L-methionine salvage (GO:0071267)	3.00007703
39	L-methionine biosynthetic process (GO:0071265)	3.00007703
40	indole-containing compound catabolic process (GO:0042436)	2.97108715
41	indolalkylamine catabolic process (GO:0046218)	2.97108715
42	tryptophan catabolic process (GO:0006569)	2.97108715
43	cellular ketone body metabolic process (GO:0046950)	2.95882095
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.95844497
45	kynurenine metabolic process (GO:0070189)	2.92433974
46	protein localization to cilium (GO:0061512)	2.90591237
47	negative regulation of telomere maintenance (GO:0032205)	2.89829999
48	protein polyglutamylation (GO:0018095)	2.89697671
49	tryptophan metabolic process (GO:0006568)	2.83264690
50	regulation of cilium movement (GO:0003352)	2.82770503
51	sequestering of actin monomers (GO:0042989)	2.78822171
52	nonmotile primary cilium assembly (GO:0035058)	2.76586374
53	C-terminal protein amino acid modification (GO:0018410)	2.75765419
54	cornea development in camera-type eye (GO:0061303)	2.75286235
55	retinal cone cell development (GO:0046549)	2.75161359
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.75022201
57	anterograde synaptic vesicle transport (GO:0048490)	2.74713087
58	ketone body metabolic process (GO:1902224)	2.74319156
59	cilium morphogenesis (GO:0060271)	2.73163973
60	replication fork processing (GO:0031297)	2.72788071
61	epithelial cilium movement (GO:0003351)	2.71046521
62	axoneme assembly (GO:0035082)	2.70270639
63	C-terminal protein lipidation (GO:0006501)	2.68636705
64	behavioral response to ethanol (GO:0048149)	2.68412270
65	GPI anchor metabolic process (GO:0006505)	2.67867042
66	regulation of hexokinase activity (GO:1903299)	2.66975946
67	regulation of glucokinase activity (GO:0033131)	2.66975946
68	positive regulation of prostaglandin secretion (GO:0032308)	2.64786119
69	electron transport chain (GO:0022900)	2.63364778
70	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.58239029
71	reflex (GO:0060004)	2.58216073
72	kidney morphogenesis (GO:0060993)	2.54935100
73	respiratory electron transport chain (GO:0022904)	2.54401260
74	neuronal action potential (GO:0019228)	2.53618371
75	cullin deneddylation (GO:0010388)	2.53052558
76	pyrimidine nucleobase catabolic process (GO:0006208)	2.52832039
77	proton transport (GO:0015992)	2.51833039
78	DNA double-strand break processing (GO:0000729)	2.51004117
79	indole-containing compound metabolic process (GO:0042430)	2.49744512
80	cilium organization (GO:0044782)	2.49693282
81	protein deneddylation (GO:0000338)	2.48826420
82	hydrogen ion transmembrane transport (GO:1902600)	2.47134827
83	rhodopsin mediated signaling pathway (GO:0016056)	2.47110458
84	positive regulation of fatty acid transport (GO:2000193)	2.47043637
85	hydrogen transport (GO:0006818)	2.47035156
86	signal peptide processing (GO:0006465)	2.46795779
87	multicellular organism reproduction (GO:0032504)	2.46688810
88	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.46390276
89	inositol phosphate catabolic process (GO:0071545)	2.46195332
90	tRNA processing (GO:0008033)	2.44680665
91	S-adenosylmethionine metabolic process (GO:0046500)	2.44504561
92	photoreceptor cell maintenance (GO:0045494)	2.41445174
93	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.41087425
94	cilium assembly (GO:0042384)	2.40617550
95	somite development (GO:0061053)	2.40160618
96	intraciliary transport (GO:0042073)	2.39822783
97	sulfation (GO:0051923)	2.39180249
98	metallo-sulfur cluster assembly (GO:0031163)	2.37819281
99	iron-sulfur cluster assembly (GO:0016226)	2.37819281
100	proteasome assembly (GO:0043248)	2.37615192

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.90475454
2	VDR_22108803_ChIP-Seq_LS180_Human	3.11909153
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69329901
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.68502221
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53011394
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48049081
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46939293
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.45997977
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37443665
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.36655116
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30234682
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.27042173
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.18867621
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17297681
15	EWS_26573619_Chip-Seq_HEK293_Human	2.15302614
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15208913
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.07511832
18	FUS_26573619_Chip-Seq_HEK293_Human	2.04460929
19	P300_19829295_ChIP-Seq_ESCs_Human	2.01367018
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96232361
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.92278726
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88202713
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.83546235
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77584991
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70987204
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68358420
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65683636
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64996737
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.63194606
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.60684699
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.59270246
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.58752174
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56252223
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55476697
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54641636
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.53563634
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.50103642
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.50103642
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.48616541
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47655935
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.47655935
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43103778
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42182621
44	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40336530
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39444390
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39444390
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39256286
48	AR_25329375_ChIP-Seq_VCAP_Human	1.38783744
49	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.36669097
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36189685
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34767266
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34248283
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30286642
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30227512
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26971676
56	STAT3_23295773_ChIP-Seq_U87_Human	1.26607867
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25560927
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25328898
59	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23996491
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.23413241
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23354763
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.21308399
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21036693
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20544451
65	AR_20517297_ChIP-Seq_VCAP_Human	1.20321259
66	TCF4_23295773_ChIP-Seq_U87_Human	1.20151965
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19916749
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19834779
69	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.19675096
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18780842
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17635922
72	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17474065
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.17185046
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17046095
75	NCOR_22424771_ChIP-Seq_293T_Human	1.14837825
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14196162
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13767976
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13527063
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13376272
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13257407
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12787543
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12042847
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10831514
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08540531
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07826508
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07784775
87	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07784775
88	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07691179
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07174637
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06471453
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05516366
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04245990
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03518804
94	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.02771037
95	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02191767
96	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01836095
97	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.00025041
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99194250
99	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99000880
100	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97862074

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.02336942
2	MP0008877_abnormal_DNA_methylation	2.83410906
3	MP0000372_irregular_coat_pigmentation	2.72806820
4	MP0003195_calcinosis	2.69956097
5	MP0006072_abnormal_retinal_apoptosis	2.64266746
6	MP0005551_abnormal_eye_electrophysiolog	2.52418998
7	MP0002837_dystrophic_cardiac_calcinosis	2.21862296
8	MP0001968_abnormal_touch/_nociception	2.19703571
9	MP0005645_abnormal_hypothalamus_physiol	2.06980161
10	MP0005253_abnormal_eye_physiology	2.06358707
11	MP0004142_abnormal_muscle_tone	2.03161323
12	MP0008872_abnormal_physiological_respon	2.02454830
13	MP0002736_abnormal_nociception_after	2.00336947
14	MP0000569_abnormal_digit_pigmentation	1.92841449
15	MP0009046_muscle_twitch	1.90202411
16	MP0001984_abnormal_olfaction	1.89256685
17	MP0006276_abnormal_autonomic_nervous	1.86300079
18	MP0004147_increased_porphyrin_level	1.85755607
19	MP0008875_abnormal_xenobiotic_pharmacok	1.80987640
20	MP0002638_abnormal_pupillary_reflex	1.79345820
21	MP0006292_abnormal_olfactory_placode	1.77194414
22	MP0004885_abnormal_endolymph	1.75824720
23	MP0009745_abnormal_behavioral_response	1.75757208
24	MP0002938_white_spotting	1.74894896
25	MP0003787_abnormal_imprinting	1.72248851
26	MP0003880_abnormal_central_pattern	1.71137132
27	MP0001529_abnormal_vocalization	1.69836007
28	MP0003011_delayed_dark_adaptation	1.67101476
29	MP0005646_abnormal_pituitary_gland	1.65655190
30	MP0001501_abnormal_sleep_pattern	1.65508459
31	MP0002876_abnormal_thyroid_physiology	1.65237117
32	MP0005084_abnormal_gallbladder_morpholo	1.62685057
33	MP0003718_maternal_effect	1.62540466
34	MP0002272_abnormal_nervous_system	1.57748040
35	MP0001986_abnormal_taste_sensitivity	1.50243719
36	MP0003646_muscle_fatigue	1.49052930
37	MP0002735_abnormal_chemical_nociception	1.45806166
38	MP0008058_abnormal_DNA_repair	1.45586162
39	MP0004043_abnormal_pH_regulation	1.38122719
40	MP0002163_abnormal_gland_morphology	1.37958827
41	MP0000631_abnormal_neuroendocrine_gland	1.34949160
42	MP0001486_abnormal_startle_reflex	1.34364731
43	MP0002572_abnormal_emotion/affect_behav	1.33896428
44	MP0001905_abnormal_dopamine_level	1.33757606
45	MP0000427_abnormal_hair_cycle	1.31149761
46	MP0002234_abnormal_pharynx_morphology	1.28613809
47	MP0002653_abnormal_ependyma_morphology	1.27479707
48	MP0005075_abnormal_melanosome_morpholog	1.26633241
49	MP0010386_abnormal_urinary_bladder	1.25264775
50	MP0004133_heterotaxia	1.23499847
51	MP0005167_abnormal_blood-brain_barrier	1.22628166
52	MP0003136_yellow_coat_color	1.22407087
53	MP0001485_abnormal_pinna_reflex	1.21015192
54	MP0005379_endocrine/exocrine_gland_phen	1.19895601
55	MP0002733_abnormal_thermal_nociception	1.17563925
56	MP0002557_abnormal_social/conspecific_i	1.16516875
57	MP0001970_abnormal_pain_threshold	1.15665690
58	MP0004742_abnormal_vestibular_system	1.08711980
59	MP0008789_abnormal_olfactory_epithelium	1.06857433
60	MP0004924_abnormal_behavior	1.06561713
61	MP0005386_behavior/neurological_phenoty	1.06561713
62	MP0005174_abnormal_tail_pigmentation	1.05796209
63	MP0008995_early_reproductive_senescence	1.04991521
64	MP0004145_abnormal_muscle_electrophysio	1.04186729
65	MP0002064_seizures	1.03665156
66	MP0002928_abnormal_bile_duct	1.00882161
67	MP0005389_reproductive_system_phenotype	0.99295212
68	MP0003121_genomic_imprinting	0.98506889
69	MP0005410_abnormal_fertilization	0.98488905
70	MP0002067_abnormal_sensory_capabilities	0.97089212
71	MP0005671_abnormal_response_to	0.97082811
72	MP0008775_abnormal_heart_ventricle	0.96717230
73	MP0002095_abnormal_skin_pigmentation	0.95788112
74	MP0000230_abnormal_systemic_arterial	0.95144260
75	MP0005195_abnormal_posterior_eye	0.93306922
76	MP0002160_abnormal_reproductive_system	0.89968728
77	MP0001764_abnormal_homeostasis	0.88215301
78	MP0003635_abnormal_synaptic_transmissio	0.88035988
79	MP0002063_abnormal_learning/memory/cond	0.87942407
80	MP0004215_abnormal_myocardial_fiber	0.87835060
81	MP0000647_abnormal_sebaceous_gland	0.84719284
82	MP0001919_abnormal_reproductive_system	0.84285102
83	MP0002734_abnormal_mechanical_nocicepti	0.84231044
84	MP0003186_abnormal_redox_activity	0.84210418
85	MP0003786_premature_aging	0.81435739
86	MP0002909_abnormal_adrenal_gland	0.81148721
87	MP0003122_maternal_imprinting	0.79804796
88	MP0001324_abnormal_eye_pigmentation	0.78867976
89	MP0001873_stomach_inflammation	0.78469497
90	MP0002752_abnormal_somatic_nervous	0.78391370
91	MP0003119_abnormal_digestive_system	0.78177437
92	MP0002751_abnormal_autonomic_nervous	0.77242312
93	MP0003698_abnormal_male_reproductive	0.76890673
94	MP0001963_abnormal_hearing_physiology	0.76299867
95	MP0006036_abnormal_mitochondrial_physio	0.75716107
96	MP0002210_abnormal_sex_determination	0.75696015
97	MP0005332_abnormal_amino_acid	0.74018241
98	MP0001929_abnormal_gametogenesis	0.73725871
99	MP0009697_abnormal_copulation	0.73662923
100	MP0000026_abnormal_inner_ear	0.73488687

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.25792246
2	Molar tooth sign on MRI (HP:0002419)	4.14014190
3	Abnormality of midbrain morphology (HP:0002418)	4.14014190
4	True hermaphroditism (HP:0010459)	3.85245850
5	Pancreatic fibrosis (HP:0100732)	3.83964142
6	Nephronophthisis (HP:0000090)	3.59681236
7	Congenital stationary night blindness (HP:0007642)	3.55631853
8	Medial flaring of the eyebrow (HP:0010747)	3.26599435
9	Acute necrotizing encephalopathy (HP:0006965)	3.16258666
10	Abnormality of the renal cortex (HP:0011035)	3.14205154
11	Abnormality of the renal medulla (HP:0100957)	3.03510682
12	3-Methylglutaconic aciduria (HP:0003535)	3.00848440
13	Mitochondrial inheritance (HP:0001427)	2.98472046
14	Type II lissencephaly (HP:0007260)	2.97592564
15	Attenuation of retinal blood vessels (HP:0007843)	2.90649977
16	Increased CSF lactate (HP:0002490)	2.85827414
17	Progressive macrocephaly (HP:0004481)	2.85411593
18	Acute encephalopathy (HP:0006846)	2.83568592
19	Hyperventilation (HP:0002883)	2.75552837
20	Gait imbalance (HP:0002141)	2.73377008
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.70817229
22	Renal cortical cysts (HP:0000803)	2.64908358
23	Congenital primary aphakia (HP:0007707)	2.64746683
24	Abolished electroretinogram (ERG) (HP:0000550)	2.59848235
25	Inability to walk (HP:0002540)	2.56875396
26	Abnormality of alanine metabolism (HP:0010916)	2.54876077
27	Hyperalaninemia (HP:0003348)	2.54876077
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54876077
29	Hepatocellular necrosis (HP:0001404)	2.54783743
30	Large for gestational age (HP:0001520)	2.54104943
31	Lipid accumulation in hepatocytes (HP:0006561)	2.44821820
32	Optic disc pallor (HP:0000543)	2.44789876
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.44696211
34	Nephrogenic diabetes insipidus (HP:0009806)	2.44680586
35	Progressive inability to walk (HP:0002505)	2.41147045
36	Hepatic necrosis (HP:0002605)	2.40342123
37	Congenital, generalized hypertrichosis (HP:0004540)	2.40229626
38	Polydipsia (HP:0001959)	2.39395458
39	Abnormal drinking behavior (HP:0030082)	2.39395458
40	Lissencephaly (HP:0001339)	2.38342915
41	Cystic liver disease (HP:0006706)	2.37385213
42	Sclerocornea (HP:0000647)	2.31417431
43	Methylmalonic acidemia (HP:0002912)	2.31169352
44	Hypothermia (HP:0002045)	2.28993910
45	Increased hepatocellular lipid droplets (HP:0006565)	2.27165725
46	Renal Fanconi syndrome (HP:0001994)	2.23898400
47	Tubular atrophy (HP:0000092)	2.23698372
48	Abnormality of the labia minora (HP:0012880)	2.22228028
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20513023
50	Chronic hepatic failure (HP:0100626)	2.18624569
51	Cerebellar dysplasia (HP:0007033)	2.16658391
52	Genital tract atresia (HP:0001827)	2.13757613
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.13404489
54	Broad-based gait (HP:0002136)	2.13241717
55	Pendular nystagmus (HP:0012043)	2.12527432
56	Methylmalonic aciduria (HP:0012120)	2.12196434
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.09633562
58	Vaginal atresia (HP:0000148)	2.08532607
59	Increased serum lactate (HP:0002151)	2.07244924
60	Male pseudohermaphroditism (HP:0000037)	2.02929369
61	Polyuria (HP:0000103)	2.00480621
62	Abnormality of the pons (HP:0007361)	2.00418986
63	Stomach cancer (HP:0012126)	1.99356957
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.97912622
65	Cerebral edema (HP:0002181)	1.96705354
66	Postaxial foot polydactyly (HP:0001830)	1.96369621
67	Furrowed tongue (HP:0000221)	1.95461355
68	Congenital hepatic fibrosis (HP:0002612)	1.95116532
69	Severe muscular hypotonia (HP:0006829)	1.94688524
70	Anencephaly (HP:0002323)	1.94282537
71	Hemiparesis (HP:0001269)	1.91017705
72	Keratoconus (HP:0000563)	1.89270929
73	Increased corneal curvature (HP:0100692)	1.89270929
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.87729896
75	Abnormal respiratory epithelium morphology (HP:0012253)	1.87729896
76	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.87647948
77	Bile duct proliferation (HP:0001408)	1.86585500
78	Abnormal biliary tract physiology (HP:0012439)	1.86585500
79	Decreased central vision (HP:0007663)	1.86045357
80	Hypoplasia of the pons (HP:0012110)	1.84489180
81	Constricted visual fields (HP:0001133)	1.83327580
82	Postaxial hand polydactyly (HP:0001162)	1.82623395
83	Absent speech (HP:0001344)	1.82065732
84	Concave nail (HP:0001598)	1.81121183
85	Fair hair (HP:0002286)	1.80299640
86	Lactic acidosis (HP:0003128)	1.80073406
87	Intestinal atresia (HP:0011100)	1.80023525
88	Pachygyria (HP:0001302)	1.77033482
89	Gaze-evoked nystagmus (HP:0000640)	1.76574486
90	IgG deficiency (HP:0004315)	1.72904927
91	Delayed CNS myelination (HP:0002188)	1.72249926
92	Asplenia (HP:0001746)	1.71104185
93	Agitation (HP:0000713)	1.70746691
94	Colon cancer (HP:0003003)	1.70688593
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.70456537
96	Hypoproteinemia (HP:0003075)	1.69936826
97	Tachypnea (HP:0002789)	1.69456886
98	Hypoplasia of the fovea (HP:0007750)	1.66918517
99	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.66918517
100	Hyperglycinemia (HP:0002154)	1.66689366

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.65461850
2	MAP4K2	3.45616741
3	ADRBK2	3.06023802
4	WNK3	2.59385659
5	GRK1	2.56081187
6	INSRR	2.50012650
7	ZAK	2.42020910
8	BMPR1B	2.37797173
9	NUAK1	2.30593467
10	TLK1	2.26707875
11	TRIM28	1.97360261
12	CASK	1.96620968
13	WNK4	1.94452092
14	TAOK3	1.93965757
15	MAP3K4	1.93908427
16	BCKDK	1.87135132
17	MAPK13	1.81815313
18	PINK1	1.81281913
19	TXK	1.71235238
20	MST4	1.48379915
21	MAP2K7	1.48033712
22	VRK2	1.37228095
23	VRK1	1.33172442
24	TNIK	1.30590387
25	STK39	1.30021495
26	MARK1	1.23210334
27	PTK2B	1.22703322
28	DYRK2	1.17436435
29	OXSR1	1.16729904
30	PAK3	1.14031520
31	DAPK2	1.11281223
32	ACVR1B	1.10284027
33	PLK2	1.08349006
34	ADRBK1	1.04890470
35	PHKG2	1.02401880
36	PHKG1	1.02401880
37	CSNK1G2	1.00184882
38	MAP3K12	0.98659091
39	CSNK1G3	0.96966705
40	PRKCE	0.94020996
41	STK38L	0.92978463
42	CSNK1G1	0.90002430
43	MUSK	0.89653512
44	ITK	0.83810078
45	BCR	0.83424502
46	GRK7	0.83343249
47	CSNK1A1L	0.80916541
48	PLK3	0.78784755
49	TIE1	0.78547226
50	EIF2AK3	0.77554618
51	ERBB3	0.77133123
52	LIMK1	0.76150411
53	CCNB1	0.74376118
54	MKNK2	0.74299237
55	PRKCG	0.71491353
56	TGFBR1	0.69048563
57	FGFR2	0.66125006
58	PLK4	0.64163196
59	FER	0.62674644
60	NME1	0.60909996
61	IKBKB	0.59404299
62	EPHA4	0.59226402
63	RPS6KA5	0.57861655
64	FLT3	0.57232372
65	PKN1	0.56829205
66	KIT	0.56471859
67	PNCK	0.55251167
68	CAMK2A	0.54153802
69	PDK2	0.51636585
70	BUB1	0.51548652
71	CSNK1A1	0.51381379
72	STK16	0.51364786
73	PRKCQ	0.50372401
74	CHEK2	0.48901990
75	MAP2K6	0.48033670
76	PRKACA	0.46217529
77	MKNK1	0.45836717
78	PLK1	0.45723839
79	TEC	0.44420383
80	DAPK1	0.43855562
81	CDK8	0.41625732
82	CAMKK2	0.40807997
83	SRPK1	0.39146223
84	WEE1	0.38587260
85	GRK5	0.38326130
86	TSSK6	0.37717881
87	NTRK3	0.37651771
88	PRKCI	0.36633170
89	STK3	0.35832854
90	CAMK2D	0.35531360
91	PRKG1	0.35344398
92	SYK	0.33978211
93	DYRK3	0.32748556
94	PRKCA	0.31897630
95	EIF2AK2	0.31859600
96	MYLK	0.31147942
97	NTRK2	0.30899308
98	NEK1	0.29976169
99	OBSCN	0.29687333
100	PIK3CA	0.29637042

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.18849910
2	Protein export_Homo sapiens_hsa03060	2.79696994
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.74034949
4	Phototransduction_Homo sapiens_hsa04744	2.61859197
5	Parkinsons disease_Homo sapiens_hsa05012	2.45848274
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.31321931
7	Butanoate metabolism_Homo sapiens_hsa00650	2.16018877
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.10165286
9	Proteasome_Homo sapiens_hsa03050	2.08215824
10	RNA polymerase_Homo sapiens_hsa03020	1.97940885
11	Basal transcription factors_Homo sapiens_hsa03022	1.97846346
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88220889
13	Nicotine addiction_Homo sapiens_hsa05033	1.81054066
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.79880779
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79531627
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.73558874
17	Homologous recombination_Homo sapiens_hsa03440	1.70965410
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.70155167
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68774311
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.68713668
21	Huntingtons disease_Homo sapiens_hsa05016	1.68563597
22	Alzheimers disease_Homo sapiens_hsa05010	1.58186534
23	Propanoate metabolism_Homo sapiens_hsa00640	1.55012608
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.54210051
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53329131
26	RNA degradation_Homo sapiens_hsa03018	1.53007059
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50928477
28	Asthma_Homo sapiens_hsa05310	1.48640131
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.42825655
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.42563693
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.40701370
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33158638
33	Peroxisome_Homo sapiens_hsa04146	1.32089485
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.28282063
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.26454987
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25746944
37	One carbon pool by folate_Homo sapiens_hsa00670	1.14433828
38	Caffeine metabolism_Homo sapiens_hsa00232	1.14006687
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13993198
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11193711
41	Taste transduction_Homo sapiens_hsa04742	1.09643562
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.08758834
43	Morphine addiction_Homo sapiens_hsa05032	1.05616672
44	Olfactory transduction_Homo sapiens_hsa04740	1.05421535
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02848752
46	Sulfur metabolism_Homo sapiens_hsa00920	1.02129082
47	Graft-versus-host disease_Homo sapiens_hsa05332	1.01607636
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99143769
49	Type I diabetes mellitus_Homo sapiens_hsa04940	0.98517081
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95185594
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93998741
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.93247427
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93204922
54	Regulation of autophagy_Homo sapiens_hsa04140	0.91604733
55	Purine metabolism_Homo sapiens_hsa00230	0.89248172
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88430549
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87619052
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.85513708
59	Ribosome_Homo sapiens_hsa03010	0.84209395
60	Primary immunodeficiency_Homo sapiens_hsa05340	0.83980139
61	Allograft rejection_Homo sapiens_hsa05330	0.82423517
62	GABAergic synapse_Homo sapiens_hsa04727	0.79021367
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.77223529
64	Non-homologous end-joining_Homo sapiens_hsa03450	0.76471058
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76048155
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.75520099
67	Metabolic pathways_Homo sapiens_hsa01100	0.74550181
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.74211902
69	Retinol metabolism_Homo sapiens_hsa00830	0.73984346
70	Salivary secretion_Homo sapiens_hsa04970	0.73206936
71	Insulin secretion_Homo sapiens_hsa04911	0.71159802
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66287067
73	Fatty acid elongation_Homo sapiens_hsa00062	0.65607786
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65521017
75	Serotonergic synapse_Homo sapiens_hsa04726	0.65266800
76	Base excision repair_Homo sapiens_hsa03410	0.64574048
77	ABC transporters_Homo sapiens_hsa02010	0.63924797
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62980917
79	Circadian entrainment_Homo sapiens_hsa04713	0.62550904
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.61517158
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.61419928
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59984704
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59482054
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.58846407
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52545714
86	Mismatch repair_Homo sapiens_hsa03430	0.52520924
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50640558
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.48196786
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47433554
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44413886
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43496990
92	RNA transport_Homo sapiens_hsa03013	0.42251300
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40983093
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40675490
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40391025
96	Folate biosynthesis_Homo sapiens_hsa00790	0.39233738
97	Fatty acid degradation_Homo sapiens_hsa00071	0.38429619
98	Circadian rhythm_Homo sapiens_hsa04710	0.37672382
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.35653143
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.33832179

ACTG1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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