ACTG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hypotonic response (GO:0006971)6.43047874
2extracellular matrix assembly (GO:0085029)5.59715964
3chondrocyte proliferation (GO:0035988)5.41956334
4collagen fibril organization (GO:0030199)5.00801240
5sequestering of extracellular ligand from receptor (GO:0035581)4.88022593
6protein heterotrimerization (GO:0070208)4.55723761
7actin filament depolymerization (GO:0030042)4.49131387
8cell adhesion mediated by integrin (GO:0033627)4.21192131
9positive regulation of respiratory burst (GO:0060267)4.20828061
10one-carbon compound transport (GO:0019755)4.20560338
11galactose catabolic process (GO:0019388)4.18849155
12endodermal cell differentiation (GO:0035987)4.15729286
13skin morphogenesis (GO:0043589)4.12611359
14kidney mesenchyme development (GO:0072074)4.10717133
15tonic smooth muscle contraction (GO:0014820)4.10043578
16positive regulation of macrophage activation (GO:0043032)4.08655419
17apoptotic cell clearance (GO:0043277)4.06035834
18platelet aggregation (GO:0070527)3.88254077
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.87870001
20smooth muscle tissue development (GO:0048745)3.83336320
21positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.81666063
22COPI coating of Golgi vesicle (GO:0048205)3.74876151
23Golgi transport vesicle coating (GO:0048200)3.74876151
24metanephric mesenchyme development (GO:0072075)3.74438160
25peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.72917836
26wound healing, spreading of epidermal cells (GO:0035313)3.70101174
27adherens junction assembly (GO:0034333)3.67769334
28regulation of macrophage cytokine production (GO:0010935)3.64344700
29cell migration involved in heart development (GO:0060973)3.62430712
30lung lobe morphogenesis (GO:0060463)3.60972616
31gland morphogenesis (GO:0022612)3.60524397
32focal adhesion assembly (GO:0048041)3.60023794
33cell-substrate adherens junction assembly (GO:0007045)3.60023794
34urinary tract smooth muscle contraction (GO:0014848)3.59559610
35pathway-restricted SMAD protein phosphorylation (GO:0060389)3.57480506
36epithelial cell-cell adhesion (GO:0090136)3.56927549
37regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.55914406
38collagen metabolic process (GO:0032963)3.51746327
39cGMP-mediated signaling (GO:0019934)3.51729842
40positive regulation of hair follicle development (GO:0051798)3.50730224
41positive regulation of hair cycle (GO:0042635)3.50730224
42basement membrane organization (GO:0071711)3.43103324
43negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.41805420
44positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.41058743
45collagen catabolic process (GO:0030574)3.39636402
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37848429
47multicellular organismal macromolecule metabolic process (GO:0044259)3.37390800
48endocrine hormone secretion (GO:0060986)3.37010777
49barbed-end actin filament capping (GO:0051016)3.34155166
50glial cell migration (GO:0008347)3.33378124
51protein retention in ER lumen (GO:0006621)3.33155677
52protein localization to cell surface (GO:0034394)3.32215714
53extracellular fibril organization (GO:0043206)3.30850417
54multicellular organismal catabolic process (GO:0044243)3.27894631
55stress fiber assembly (GO:0043149)3.26483505
56multicellular organismal metabolic process (GO:0044236)3.25475098
57keratan sulfate catabolic process (GO:0042340)3.24958087
58opsonization (GO:0008228)3.24328105
59positive regulation of actin filament depolymerization (GO:0030836)3.24059586
60mesodermal cell differentiation (GO:0048333)3.23459938
61retina vasculature morphogenesis in camera-type eye (GO:0061299)3.22040312
62cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.19522712
63regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.18085430
64fibril organization (GO:0097435)3.17104081
65negative regulation of complement activation (GO:0045916)3.15004911
66cell-substrate junction assembly (GO:0007044)3.14425901
67positive regulation of endothelial cell apoptotic process (GO:2000353)3.12285536
68fibroblast migration (GO:0010761)3.07088323
69muscle cell migration (GO:0014812)3.06547736
70growth hormone secretion (GO:0030252)3.04525125
71extracellular matrix disassembly (GO:0022617)3.04103139
72mesenchymal-epithelial cell signaling (GO:0060638)3.03361688
73type B pancreatic cell proliferation (GO:0044342)2.96281410
74regulation of smooth muscle cell differentiation (GO:0051150)2.95501429
75cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.94882032
76regulation of tight junction assembly (GO:2000810)2.94358854
77positive regulation of SMAD protein import into nucleus (GO:0060391)2.94133498
78regulation of integrin-mediated signaling pathway (GO:2001044)2.93978134
79renal filtration (GO:0097205)2.92727779
80regulation of transforming growth factor beta2 production (GO:0032909)2.91555704
81lymphangiogenesis (GO:0001946)2.90567784
82positive regulation of epithelial to mesenchymal transition (GO:0010718)2.89840636
83platelet degranulation (GO:0002576)2.88662135
84endocardial cushion development (GO:0003197)2.88593066
85relaxation of smooth muscle (GO:0044557)2.88550931
86chondrocyte development (GO:0002063)2.86523841
87cellular response to osmotic stress (GO:0071470)2.85923294
88virion attachment to host cell (GO:0019062)2.85637567
89adhesion of symbiont to host cell (GO:0044650)2.85637567
90negative regulation of chondrocyte differentiation (GO:0032331)2.84653540
91peptidyl-proline hydroxylation (GO:0019511)2.84410841
92hemidesmosome assembly (GO:0031581)2.83813161
93vascular endothelial growth factor signaling pathway (GO:0038084)2.83739585
94wound healing, spreading of cells (GO:0044319)2.83187276
95peptide cross-linking (GO:0018149)2.82416697
96glomerular basement membrane development (GO:0032836)2.82171331
97regulation of hair follicle development (GO:0051797)2.81868967
98regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.81729051
99smooth muscle contraction (GO:0006939)2.80946980
100cellular response to vitamin (GO:0071295)2.80369731
101glomerular filtration (GO:0003094)2.79888085
102paraxial mesoderm development (GO:0048339)2.77138918
103hippo signaling (GO:0035329)2.76462358
104regulation of SMAD protein import into nucleus (GO:0060390)2.76369382
105negative regulation of fatty acid transport (GO:2000192)2.76242542
106cardiac cell development (GO:0055006)2.76096351
107insulin-like growth factor receptor signaling pathway (GO:0048009)2.75470114
108substrate adhesion-dependent cell spreading (GO:0034446)2.74396723
109UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74375960
110bone trabecula formation (GO:0060346)2.73883488
111cell aggregation (GO:0098743)2.73329399
112cartilage condensation (GO:0001502)2.73329399
113dermatan sulfate biosynthetic process (GO:0030208)2.72617192
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.72588925
115regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.72137115
116endothelial cell morphogenesis (GO:0001886)2.72108106
117substrate-dependent cell migration (GO:0006929)2.71511237
118cell migration involved in sprouting angiogenesis (GO:0002042)2.70342548
119cardiac muscle cell development (GO:0055013)2.70236204
120artery morphogenesis (GO:0048844)2.70160253
121negative regulation of smooth muscle cell migration (GO:0014912)2.69182173
122cellular response to interferon-alpha (GO:0035457)2.67894008
123embryonic skeletal joint morphogenesis (GO:0060272)2.67555670
124regulation of plasminogen activation (GO:0010755)2.67441481
125decidualization (GO:0046697)2.66313376
126dermatan sulfate metabolic process (GO:0030205)2.65077819
127positive regulation of blood vessel endothelial cell migration (GO:0043536)2.63140847
128cardiac muscle cell proliferation (GO:0060038)2.62266099
129cyclooxygenase pathway (GO:0019371)2.62224046
130homotypic cell-cell adhesion (GO:0034109)2.61628038
131branching involved in prostate gland morphogenesis (GO:0060442)2.60762592
132detection of molecule of bacterial origin (GO:0032490)2.60498272
133cell-matrix adhesion (GO:0007160)2.60205423
134uterus development (GO:0060065)2.60189879
135prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.59039286
136angiogenesis involved in wound healing (GO:0060055)2.58956241
137import into cell (GO:0098657)2.58721724
138regulation of skeletal muscle contraction (GO:0014819)2.58419475
139chondroitin sulfate biosynthetic process (GO:0030206)2.56940308
140adhesion of symbiont to host (GO:0044406)2.54403605
141neuron projection extension involved in neuron projection guidance (GO:1902284)2.53393676
142axon extension involved in axon guidance (GO:0048846)2.53393676
143extracellular matrix organization (GO:0030198)2.52368371
144lung vasculature development (GO:0060426)2.52189006
145sulfur amino acid catabolic process (GO:0000098)2.51935683
146potassium ion homeostasis (GO:0055075)2.51343277
147extracellular structure organization (GO:0043062)2.51316813
148positive regulation of cartilage development (GO:0061036)2.49935204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.20456646
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.56341431
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.33810960
4CLOCK_20551151_ChIP-Seq_293T_Human3.23609685
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.23438114
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75034512
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66687347
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.59159776
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.56575506
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.51970520
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.43520883
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.41138720
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37750245
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23739613
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.21768245
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.17818874
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.17713169
18SOX2_20726797_ChIP-Seq_SW620_Human2.11923291
19CJUN_26792858_Chip-Seq_BT549_Human2.10017871
20PPAR_26484153_Chip-Seq_NCI-H1993_Human2.03821520
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.01373912
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00214512
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99269501
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.98444092
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94418448
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94418448
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.86841848
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86075940
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78896815
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.78478546
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76704658
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75201722
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74705631
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.72337028
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.72288958
36RACK7_27058665_Chip-Seq_MCF-7_Human1.69309585
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66169708
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65071875
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.64470015
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63276704
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61300929
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59160408
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57040128
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57040128
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55278829
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54206789
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53942182
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.53828513
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.52329662
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52271034
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.50594993
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50358105
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.49985928
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48890859
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45663402
56BRD4_25478319_ChIP-Seq_HGPS_Human1.43984154
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43584647
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43584647
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42303605
60ATF3_27146783_Chip-Seq_COLON_Human1.37229466
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37015723
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36806678
63ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.36652683
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35301712
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33937435
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33781869
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33693919
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32127931
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.30162055
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29654359
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.28627035
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28535042
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28504025
74GATA4_25053715_ChIP-Seq_YYC3_Human1.27330375
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24528421
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24009116
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23779578
78TP53_22127205_ChIP-Seq_IMR90_Human1.22577447
79LXR_22292898_ChIP-Seq_THP-1_Human1.21712695
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21020836
81KLF5_25053715_ChIP-Seq_YYC3_Human1.20783612
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19745865
83AHR_22903824_ChIP-Seq_MCF-7_Human1.19229487
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.15649002
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15444689
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15300377
87GBX2_23144817_ChIP-Seq_PC3_Human1.13767976
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.12896355
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12044881
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11699437
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.11270727
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10546044
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10417803
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10307730
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09953600
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09710810
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.09045409
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.08580890
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.08580890
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08215399
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08046759
102TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07442984
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07007716
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04431920
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04203782
106TP53_18474530_ChIP-ChIP_U2OS_Human1.02444154
107DROSHA_22980978_ChIP-Seq_HELA_Human1.00265569
108CSB_26484114_Chip-Seq_FIBROBLAST_Human0.99983965
109GATA6_25053715_ChIP-Seq_YYC3_Human0.99213424
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97712536
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97587991
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97275017
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95761226
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.94200350
115FOXA2_19822575_ChIP-Seq_HepG2_Human0.94066134
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.92032689
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.91165886
118LXR_22158963_ChIP-Seq_LIVER_Mouse0.90935410
119EZH2_27304074_Chip-Seq_ESCs_Mouse0.90414039
120TP53_16413492_ChIP-PET_HCT116_Human0.90214236
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90017508
122TP53_23651856_ChIP-Seq_MEFs_Mouse0.89822522
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89281038
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88310050
125TP63_22573176_ChIP-Seq_HFKS_Human0.86608977
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86359425
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.85695673
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85359894
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84907895
130ZNF263_19887448_ChIP-Seq_K562_Human0.84610455
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84328790
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83088408
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82873251
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82419640
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81587882
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81358407
137ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80963323
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80665503
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.79242706
140RXR_22158963_ChIP-Seq_LIVER_Mouse0.78732004
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78555907
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78483129
143EOMES_21245162_ChIP-Seq_HESCs_Human0.78456845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.14679816
2MP0010386_abnormal_urinary_bladder4.91103839
3MP0000516_abnormal_urinary_system4.09926002
4MP0005367_renal/urinary_system_phenotyp4.09926002
5MP0006054_spinal_hemorrhage3.96727669
6MP0005275_abnormal_skin_tensile3.62809204
7MP0008004_abnormal_stomach_pH3.26139670
8MP0001958_emphysema2.88839614
9MP0003705_abnormal_hypodermis_morpholog2.82678672
10MP0005503_abnormal_tendon_morphology2.71998208
11MP0003566_abnormal_cell_adhesion2.68595156
12MP0000013_abnormal_adipose_tissue2.52672647
13MP0003279_aneurysm2.48738990
14MP0001664_abnormal_digestion2.41481912
15MP0010352_gastrointestinal_tract_polyps2.35042110
16MP0004272_abnormal_basement_membrane2.22260500
17MP0000534_abnormal_ureter_morphology2.22093462
18MP0000462_abnormal_digestive_system2.15667727
19MP0002254_reproductive_system_inflammat2.08165295
20MP0001756_abnormal_urination1.92921873
21MP0005023_abnormal_wound_healing1.79850300
22MP0001542_abnormal_bone_strength1.74075611
23MP0002108_abnormal_muscle_morphology1.60542050
24MP0000538_abnormal_urinary_bladder1.59305270
25MP0005623_abnormal_meninges_morphology1.50664316
26MP0009384_cardiac_valve_regurgitation1.49911834
27MP0009780_abnormal_chondrocyte_physiolo1.49414476
28MP0003045_fibrosis1.47980922
29MP0010234_abnormal_vibrissa_follicle1.46561999
30MP0002060_abnormal_skin_morphology1.44548020
31MP0003091_abnormal_cell_migration1.43983071
32MP0005164_abnormal_response_to1.40052156
33MP0002837_dystrophic_cardiac_calcinosis1.35352914
34MP0003385_abnormal_body_wall1.33582759
35MP0000537_abnormal_urethra_morphology1.33406946
36MP0004036_abnormal_muscle_relaxation1.28610512
37MP0006138_congestive_heart_failure1.27336506
38MP0000750_abnormal_muscle_regeneration1.26771846
39MP0002295_abnormal_pulmonary_circulatio1.25954670
40MP0005508_abnormal_skeleton_morphology1.22033603
41MP0000767_abnormal_smooth_muscle1.21394181
42MP0000762_abnormal_tongue_morphology1.20266867
43MP0000003_abnormal_adipose_tissue1.19289462
44MP0000230_abnormal_systemic_arterial1.16477539
45MP0004134_abnormal_chest_morphology1.15386014
46MP0001765_abnormal_ion_homeostasis1.15071984
47MP0005381_digestive/alimentary_phenotyp1.13827324
48MP0003300_gastrointestinal_ulcer1.06457909
49MP0005257_abnormal_intraocular_pressure1.06218698
50MP0003283_abnormal_digestive_organ1.05978061
51MP0005620_abnormal_muscle_contractility1.04620189
52MP0001533_abnormal_skeleton_physiology1.04374684
53MP0009250_abnormal_appendicular_skeleto1.02207596
54MP0002282_abnormal_trachea_morphology1.01983012
55MP0004145_abnormal_muscle_electrophysio1.00283292
56MP0000681_abnormal_thyroid_gland0.99753862
57MP0000751_myopathy0.98848728
58MP0005330_cardiomyopathy0.97892370
59MP0003866_abnormal_defecation0.95595378
60MP0010368_abnormal_lymphatic_system0.94667125
61MP0002128_abnormal_blood_circulation0.94648636
62MP0004858_abnormal_nervous_system0.94238250
63MP0005595_abnormal_vascular_smooth0.94018701
64MP0002896_abnormal_bone_mineralization0.93994916
65MP0000749_muscle_degeneration0.93767752
66MP0001243_abnormal_dermal_layer0.92344309
67MP0004084_abnormal_cardiac_muscle0.90276255
68MP0005409_darkened_coat_color0.88020029
69MP0005375_adipose_tissue_phenotype0.87701720
70MP0001879_abnormal_lymphatic_vessel0.87681596
71MP0002115_abnormal_skeleton_extremities0.86254038
72MP0005390_skeleton_phenotype0.86091893
73MP0002127_abnormal_cardiovascular_syste0.85739963
74MP0005166_decreased_susceptibility_to0.85514384
75MP0000249_abnormal_blood_vessel0.85387235
76MP0009053_abnormal_anal_canal0.84427995
77MP0000477_abnormal_intestine_morphology0.83504268
78MP0002998_abnormal_bone_remodeling0.82424393
79MP0000163_abnormal_cartilage_morphology0.82340443
80MP0005058_abnormal_lysosome_morphology0.80635320
81MP0000049_abnormal_middle_ear0.80064410
82MP0001663_abnormal_digestive_system0.79510267
83MP0002933_joint_inflammation0.77414622
84MP0001270_distended_abdomen0.77247725
85MP0010155_abnormal_intestine_physiology0.76200035
86MP0002932_abnormal_joint_morphology0.76021584
87MP0000858_altered_metastatic_potential0.75960795
88MP0001661_extended_life_span0.75643536
89MP0002168_other_aberrant_phenotype0.74807744
90MP0000343_altered_response_to0.74021496
91MP0000432_abnormal_head_morphology0.73591191
92MP0010030_abnormal_orbit_morphology0.73320751
93MP0004883_abnormal_blood_vessel0.73276819
94MP0005410_abnormal_fertilization0.73005266
95MP0003755_abnormal_palate_morphology0.72765100
96MP0002113_abnormal_skeleton_development0.72517966
97MP0001614_abnormal_blood_vessel0.71442282
98MP0005193_abnormal_anterior_eye0.71259862
99MP0003795_abnormal_bone_structure0.70491537
100MP0005670_abnormal_white_adipose0.69867851
101MP0009643_abnormal_urine_homeostasis0.69691559
102MP0000470_abnormal_stomach_morphology0.69625073
103MP0003115_abnormal_respiratory_system0.68936013
104MP0001299_abnormal_eye_distance/0.68930805
105MP0000604_amyloidosis0.68464587
106MP0004264_abnormal_extraembryonic_tissu0.68383159
107MP0003942_abnormal_urinary_system0.68102083
108MP0002135_abnormal_kidney_morphology0.68072510
109MP0001666_abnormal_nutrient_absorption0.67904393
110MP0003950_abnormal_plasma_membrane0.67781710
111MP0004185_abnormal_adipocyte_glucose0.67248485
112MP0002925_abnormal_cardiovascular_devel0.67032060
113MP0003941_abnormal_skin_development0.66914140
114MP0003329_amyloid_beta_deposits0.66068116
115MP0003448_altered_tumor_morphology0.65649036
116MP0005171_absent_coat_pigmentation0.64713705
117MP0000465_gastrointestinal_hemorrhage0.64595761
118MP0002133_abnormal_respiratory_system0.64531590
119MP0005388_respiratory_system_phenotype0.64531590
120MP0004087_abnormal_muscle_fiber0.64526534
121MP0001881_abnormal_mammary_gland0.64347662
122MP0000627_abnormal_mammary_gland0.63942729
123MP0000733_abnormal_muscle_development0.63865511
124MP0005197_abnormal_uvea_morphology0.63352558
125MP0003935_abnormal_craniofacial_develop0.63092997
126MP0000428_abnormal_craniofacial_morphol0.61355049
127MP0003868_abnormal_feces_composition0.60852978
128MP0000266_abnormal_heart_morphology0.59654560
129MP0002114_abnormal_axial_skeleton0.59598999
130MP0002116_abnormal_craniofacial_bone0.58140260
131MP0001849_ear_inflammation0.55306974
132MP0002109_abnormal_limb_morphology0.54803607
133MP0002877_abnormal_melanocyte_morpholog0.54309950
134MP0000759_abnormal_skeletal_muscle0.53612347

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)9.64838038
2Aortic dissection (HP:0002647)9.35508620
3Premature rupture of membranes (HP:0001788)5.56740231
4Cerebral aneurysm (HP:0004944)5.33110914
5Protrusio acetabuli (HP:0003179)4.86036245
6Ankle contracture (HP:0006466)4.77521656
7Facial diplegia (HP:0001349)4.77089629
8Increased density of long bones (HP:0006392)4.73564553
9Papilledema (HP:0001085)3.96182530
10Type 1 muscle fiber predominance (HP:0003803)3.83132887
11Dilatation of the ascending aorta (HP:0005111)3.79022007
12Ulnar bowing (HP:0003031)3.72028471
13Aneurysm (HP:0002617)3.71184782
14Aortic regurgitation (HP:0001659)3.67338171
15Arterial tortuosity (HP:0005116)3.63588930
16Vascular tortuosity (HP:0004948)3.60969444
17Right ventricular cardiomyopathy (HP:0011663)3.54122270
18Osteolytic defects of the phalanges of the hand (HP:0009771)3.48974044
19Osteolytic defects of the hand bones (HP:0009699)3.48974044
20Bicuspid aortic valve (HP:0001647)3.41309252
21Spondylolisthesis (HP:0003302)3.34169616
22Scapular winging (HP:0003691)3.24988447
23Radial bowing (HP:0002986)3.21075685
24Atrophic scars (HP:0001075)3.18880957
25Mitral valve prolapse (HP:0001634)3.08218558
26* Gastrointestinal dysmotility (HP:0002579)3.07297826
27Genu recurvatum (HP:0002816)3.07010257
28Peritonitis (HP:0002586)2.96916422
29Cervical subluxation (HP:0003308)2.93805961
30Soft skin (HP:0000977)2.93059070
31Spinal rigidity (HP:0003306)2.92417415
32Absent frontal sinuses (HP:0002688)2.91868687
33Wrist flexion contracture (HP:0001239)2.91710369
34Abnormality of the calcaneus (HP:0008364)2.88723501
35Broad metatarsal (HP:0001783)2.82758615
36Hypoventilation (HP:0002791)2.82368761
37Wormian bones (HP:0002645)2.82307797
38Fragile skin (HP:0001030)2.79240287
39Elbow flexion contracture (HP:0002987)2.78698852
40Joint laxity (HP:0001388)2.74995150
41Short hallux (HP:0010109)2.62965404
42Tarsal synostosis (HP:0008368)2.60833999
43Persistence of primary teeth (HP:0006335)2.58002108
44Bowing of the arm (HP:0006488)2.57853319
45Bowed forearm bones (HP:0003956)2.57853319
46Long toe (HP:0010511)2.56974963
47Shallow orbits (HP:0000586)2.55308861
48Infantile muscular hypotonia (HP:0008947)2.54525806
49Increased connective tissue (HP:0009025)2.53886824
50Slender build (HP:0001533)2.49192895
51Abnormality of dentin (HP:0010299)2.46413758
52Mesomelia (HP:0003027)2.46260361
53Increased variability in muscle fiber diameter (HP:0003557)2.45997738
54Aplasia/Hypoplasia of the hallux (HP:0008362)2.40843762
55Broad face (HP:0000283)2.38872902
56Bowel diverticulosis (HP:0005222)2.38850591
57Hyporeflexia of lower limbs (HP:0002600)2.37664529
58Blue sclerae (HP:0000592)2.37431896
59Hydroureter (HP:0000072)2.37139264
60Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.35260337
61Follicular hyperkeratosis (HP:0007502)2.34398213
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33212753
63Short 4th metacarpal (HP:0010044)2.33212753
64Camptodactyly of toe (HP:0001836)2.32647798
65Round ear (HP:0100830)2.29883805
66Mildly elevated creatine phosphokinase (HP:0008180)2.29404518
67Synostosis involving bones of the feet (HP:0009140)2.28543725
68Synostosis involving bones of the lower limbs (HP:0009138)2.28543725
69Biconcave vertebral bodies (HP:0004586)2.26837652
70Ectopia lentis (HP:0001083)2.23966544
71Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.23918849
72Stridor (HP:0010307)2.22734812
73Knee flexion contracture (HP:0006380)2.21638597
74Abnormality of the 2nd finger (HP:0004100)2.19811178
75Broad distal phalanx of finger (HP:0009836)2.17925931
76Delayed closure of the anterior fontanelle (HP:0001476)2.16188826
77Hip contracture (HP:0003273)2.15127095
78Ulnar deviation of the wrist (HP:0003049)2.14774264
79Ileus (HP:0002595)2.13308693
80Coronal craniosynostosis (HP:0004440)2.12574005
81Vertebral compression fractures (HP:0002953)2.12467890
82Bladder diverticulum (HP:0000015)2.11115450
83Pulmonary artery stenosis (HP:0004415)2.10938813
84Abnormality of skeletal muscle fiber size (HP:0012084)2.10845126
85Abnormal delivery (HP:0001787)2.09242449
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08744368
87Calcaneovalgus deformity (HP:0001848)2.06777888
88Increased mean platelet volume (HP:0011877)2.04923970
89Mitral regurgitation (HP:0001653)2.03682139
90Short clavicles (HP:0000894)2.02781415
91Myopathic facies (HP:0002058)2.02639670
92Tibial bowing (HP:0002982)2.01506672
93Abnormality of the acetabulum (HP:0003170)2.01063967
94Abnormal foot bone ossification (HP:0010675)2.00524171
95Mild short stature (HP:0003502)1.99570780
96Limited hip movement (HP:0008800)1.99436836
97Wide anterior fontanel (HP:0000260)1.98108210
98Neonatal short-limb short stature (HP:0008921)1.97481547
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.97148092
100Broad ribs (HP:0000885)1.96550381
101Abnormality of the 4th metacarpal (HP:0010012)1.93561921
102Disproportionate tall stature (HP:0001519)1.91243611
103Stroke (HP:0001297)1.90608842
104Distal arthrogryposis (HP:0005684)1.89492191
105Hyperextensible skin (HP:0000974)1.88623316
106Overgrowth (HP:0001548)1.88133581
107Back pain (HP:0003418)1.87600035
108Broad long bones (HP:0005622)1.86730848
109Hypoplasia of the iris (HP:0007676)1.86334767
110Abnormality of the phalanges of the hallux (HP:0010057)1.85727602
111Femoral bowing (HP:0002980)1.83478940
112Deformed tarsal bones (HP:0008119)1.82220673
113Abnormal ossification of hand bones (HP:0005921)1.81208724
114Osteoarthritis (HP:0002758)1.81126780
115Trismus (HP:0000211)1.80651130
116Premature skin wrinkling (HP:0100678)1.79165236
117Aplasia/Hypoplasia of the clavicles (HP:0006710)1.77988374
118Selective tooth agenesis (HP:0001592)1.77034383
119Long foot (HP:0001833)1.75871079
120Abnormality of the shoulder girdle musculature (HP:0001435)1.75764411
121Limb-girdle muscle atrophy (HP:0003797)1.75495058
122Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.75039767
123Thin bony cortex (HP:0002753)1.75030089
124Flared iliac wings (HP:0002869)1.73904568
125Congenital hip dislocation (HP:0001374)1.71002935
126Venous insufficiency (HP:0005293)1.69789503
127Aortic valve stenosis (HP:0001650)1.69403287
128Vertebral arch anomaly (HP:0008438)1.66184929
129Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63663630
130Venous abnormality (HP:0002624)1.61291351
131Joint stiffness (HP:0001387)1.61067196
132Natal tooth (HP:0000695)1.60320349
133Rectal prolapse (HP:0002035)1.59450818
134Abnormality of the calf musculature (HP:0001430)1.58657152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK8.52044767
2TTN6.22167347
3TESK13.85498934
4PIK3CG3.52430346
5DMPK3.26626523
6PAK23.11808073
7DDR22.30696918
8LIMK12.29648673
9TRIB32.13236422
10MAPKAPK32.06617234
11LMTK21.96445866
12ERN11.86643745
13MST1R1.71363939
14PIK3CA1.55409885
15PDGFRA1.54977999
16TGFBR21.51011607
17EPHB21.49730483
18CDC42BPA1.39626942
19EEF2K1.38444414
20RIPK11.33378559
21PAK11.31419307
22PTK2B1.31088626
23DAPK31.26728344
24GRK71.24371994
25LATS11.23335941
26TESK21.19946476
27PTK21.18820572
28PAK31.18383975
29MET1.17656939
30LATS21.16842196
31FRK1.16251569
32ROCK11.13528714
33ILK1.10867785
34NUAK11.10834111
35PDK21.03115713
36LRRK21.02289810
37FER1.01019102
38TRPM70.98157575
39PRKD20.95472346
40PKN20.92376434
41PTK60.91147048
42WNK10.85890829
43STK240.81929577
44MAP3K60.80101287
45AKT30.77724555
46MAP3K70.75465998
47MAP2K10.72171920
48KDR0.71741029
49CAMK2G0.69721489
50CLK10.68789678
51PDK30.67868036
52PDK40.67868036
53MST40.67407886
54PAK40.67216910
55PRKG20.66980774
56ROCK20.66145064
57ACVR1B0.66073876
58PIM20.65267864
59RPS6KB20.64074324
60RPS6KA20.63515008
61BMX0.63395508
62TIE10.62484446
63EPHB10.62308862
64MARK20.60445108
65MAPK150.58070904
66NLK0.57565054
67EPHA20.55859606
68MAP3K30.55559904
69KIT0.54427246
70RAF10.53070798
71SIK10.52156001
72STK100.51874060
73TAOK30.51834691
74ADRBK10.51582170
75MAP3K20.49512870
76STK30.48229900
77MAPKAPK20.47756436
78MINK10.46191180
79CAMK1G0.45428834
80MAPK70.44515279
81CAMK1D0.44090913
82MELK0.42858691
83GSK3A0.41648861
84MAPKAPK50.40926283
85MAP3K100.40664480
86KSR20.39905850
87PRKAA20.39643318
88PDGFRB0.39574555
89FYN0.37839496
90STK38L0.36665400
91STK390.36398540
92STK380.34390509
93MAP2K30.34372543
94MTOR0.34259221
95PRKAA10.32108482
96SRC0.31797601
97ICK0.31183526
98FGFR10.30048195
99EPHA30.29599954
100NTRK10.29166017
101TAOK10.28047956
102INSR0.27036549
103NEK90.26821460
104WNK40.26699658
105PRKD30.26518875
106PRKD10.26108918
107MAPK10.25582467
108MAP3K80.24950358
109CAMK10.23780760
110SCYL20.23408256
111RPS6KC10.22807978
112RPS6KL10.22807978
113FGFR20.21885751
114FLT30.21497667
115CAMK2B0.21397823
116JAK30.21389809
117MAP2K20.21088495
118MAPK40.20250137
119FGFR40.20202030
120RET0.19718407
121MAP3K130.19693752
122ERBB30.18732177
123DYRK1B0.18643981
124PRKCI0.17680969
125CAMK2D0.17467613
126PDPK10.17459903
127RPS6KA60.16457146
128CDK120.15848956
129ABL20.13790305
130PRKACB0.13172681
131PRKG10.12767231

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.28373262
2Focal adhesion_Homo sapiens_hsa045103.00366453
3* Vascular smooth muscle contraction_Homo sapiens_hsa042702.58369351
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.42147851
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.35893851
6Bladder cancer_Homo sapiens_hsa052192.34599768
7Sulfur metabolism_Homo sapiens_hsa009202.26097742
8Amoebiasis_Homo sapiens_hsa051462.17242581
9Dilated cardiomyopathy_Homo sapiens_hsa054142.04355112
10Proteoglycans in cancer_Homo sapiens_hsa052052.04186806
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.00301308
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86818038
13Protein digestion and absorption_Homo sapiens_hsa049741.84091791
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78830259
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.71548754
16TGF-beta signaling pathway_Homo sapiens_hsa043501.70803993
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68302629
18Adherens junction_Homo sapiens_hsa045201.62098586
19Tight junction_Homo sapiens_hsa045301.60889289
20Regulation of actin cytoskeleton_Homo sapiens_hsa048101.55467570
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.49061626
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42925785
23Glutathione metabolism_Homo sapiens_hsa004801.41369066
24Gastric acid secretion_Homo sapiens_hsa049711.41168963
25Platelet activation_Homo sapiens_hsa046111.37692991
26Shigellosis_Homo sapiens_hsa051311.36798957
27Mineral absorption_Homo sapiens_hsa049781.32777190
28Other glycan degradation_Homo sapiens_hsa005111.29662378
29Malaria_Homo sapiens_hsa051441.29116267
30Salmonella infection_Homo sapiens_hsa051321.28388622
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27808885
32Prostate cancer_Homo sapiens_hsa052151.25185049
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23415144
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22444725
35Arachidonic acid metabolism_Homo sapiens_hsa005901.18518055
36Small cell lung cancer_Homo sapiens_hsa052221.18490198
37Hippo signaling pathway_Homo sapiens_hsa043901.18114719
38Hedgehog signaling pathway_Homo sapiens_hsa043401.17587457
39Thyroid hormone synthesis_Homo sapiens_hsa049181.16783180
40Lysosome_Homo sapiens_hsa041421.14769141
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10706165
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10030869
43Chronic myeloid leukemia_Homo sapiens_hsa052201.06050716
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05640965
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03572219
46Melanogenesis_Homo sapiens_hsa049161.01045116
47Bile secretion_Homo sapiens_hsa049761.00685944
48PPAR signaling pathway_Homo sapiens_hsa033200.98675403
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97394265
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97338624
51Basal cell carcinoma_Homo sapiens_hsa052170.97332130
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96602828
53Leishmaniasis_Homo sapiens_hsa051400.96351824
54Toxoplasmosis_Homo sapiens_hsa051450.96146976
55Pertussis_Homo sapiens_hsa051330.93780843
56Cocaine addiction_Homo sapiens_hsa050300.92694418
57Chemical carcinogenesis_Homo sapiens_hsa052040.91377514
58Notch signaling pathway_Homo sapiens_hsa043300.89888917
59MicroRNAs in cancer_Homo sapiens_hsa052060.89565684
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88068650
61Vibrio cholerae infection_Homo sapiens_hsa051100.87497946
62Melanoma_Homo sapiens_hsa052180.84614205
63cAMP signaling pathway_Homo sapiens_hsa040240.84262963
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83895984
65Calcium signaling pathway_Homo sapiens_hsa040200.79636068
66Nitrogen metabolism_Homo sapiens_hsa009100.79528820
67Phagosome_Homo sapiens_hsa041450.79365062
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78738698
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.78530393
70Caffeine metabolism_Homo sapiens_hsa002320.77967154
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76911572
72Pancreatic cancer_Homo sapiens_hsa052120.76623345
73Oxytocin signaling pathway_Homo sapiens_hsa049210.76322566
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76242941
75Dorso-ventral axis formation_Homo sapiens_hsa043200.75597160
76N-Glycan biosynthesis_Homo sapiens_hsa005100.75055675
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73091815
78Complement and coagulation cascades_Homo sapiens_hsa046100.71117524
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71063281
80Fat digestion and absorption_Homo sapiens_hsa049750.68598040
81Insulin secretion_Homo sapiens_hsa049110.68166943
82Axon guidance_Homo sapiens_hsa043600.67122422
83VEGF signaling pathway_Homo sapiens_hsa043700.66012028
84Salivary secretion_Homo sapiens_hsa049700.65292655
85mTOR signaling pathway_Homo sapiens_hsa041500.65254062
86Cholinergic synapse_Homo sapiens_hsa047250.65252254
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64051419
88Rap1 signaling pathway_Homo sapiens_hsa040150.63201122
89Circadian rhythm_Homo sapiens_hsa047100.63182954
90Sphingolipid metabolism_Homo sapiens_hsa006000.61966596
91Glioma_Homo sapiens_hsa052140.61248592
92Viral myocarditis_Homo sapiens_hsa054160.60649278
93Wnt signaling pathway_Homo sapiens_hsa043100.59046602
94Renin-angiotensin system_Homo sapiens_hsa046140.58753977
95Tuberculosis_Homo sapiens_hsa051520.58394562
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56998944
97Endocytosis_Homo sapiens_hsa041440.56968388
98Lysine degradation_Homo sapiens_hsa003100.55853646
99MAPK signaling pathway_Homo sapiens_hsa040100.54978432
100Osteoclast differentiation_Homo sapiens_hsa043800.54782586
101FoxO signaling pathway_Homo sapiens_hsa040680.54740695
102TNF signaling pathway_Homo sapiens_hsa046680.52978146
103Vitamin digestion and absorption_Homo sapiens_hsa049770.52272656
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51885429
105Histidine metabolism_Homo sapiens_hsa003400.51753410
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49223295
107Long-term depression_Homo sapiens_hsa047300.48446740
108Choline metabolism in cancer_Homo sapiens_hsa052310.47890583
109Glucagon signaling pathway_Homo sapiens_hsa049220.47019998
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.46999720
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46643166
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46241501
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45801212
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45470263
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45165218
116Rheumatoid arthritis_Homo sapiens_hsa053230.44626283
117Insulin signaling pathway_Homo sapiens_hsa049100.44306637
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.41601192
119Glycerolipid metabolism_Homo sapiens_hsa005610.41460324
120Pathways in cancer_Homo sapiens_hsa052000.41132855
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40780971
122Amphetamine addiction_Homo sapiens_hsa050310.39389970
123Circadian entrainment_Homo sapiens_hsa047130.39301275
124Apoptosis_Homo sapiens_hsa042100.38815614
125Ras signaling pathway_Homo sapiens_hsa040140.38810051
126Hematopoietic cell lineage_Homo sapiens_hsa046400.37071802
127Phenylalanine metabolism_Homo sapiens_hsa003600.36969042
128GnRH signaling pathway_Homo sapiens_hsa049120.36908184
129Colorectal cancer_Homo sapiens_hsa052100.36734717
130Renin secretion_Homo sapiens_hsa049240.36215193
131Endometrial cancer_Homo sapiens_hsa052130.35157719
132AMPK signaling pathway_Homo sapiens_hsa041520.34959387
133Pancreatic secretion_Homo sapiens_hsa049720.34582024
134Insulin resistance_Homo sapiens_hsa049310.34171316
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.33421023
136Renal cell carcinoma_Homo sapiens_hsa052110.33334871
137Prolactin signaling pathway_Homo sapiens_hsa049170.32491457
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32436661
139HIF-1 signaling pathway_Homo sapiens_hsa040660.31359099
140Gap junction_Homo sapiens_hsa045400.31342810
141Estrogen signaling pathway_Homo sapiens_hsa049150.31083062
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.30928081
143Inositol phosphate metabolism_Homo sapiens_hsa005620.30351187
144Fatty acid degradation_Homo sapiens_hsa000710.28891280

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