ACTL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.76590878
2cell-cell recognition (GO:0009988)9.42583079
3multicellular organism reproduction (GO:0032504)9.11600981
4spermatid development (GO:0007286)8.94526007
5epithelial cilium movement (GO:0003351)8.89157366
6plasma membrane fusion (GO:0045026)8.59765489
7axonemal dynein complex assembly (GO:0070286)8.37001476
8motile cilium assembly (GO:0044458)8.30322998
9reproduction (GO:0000003)8.21729510
10cilium or flagellum-dependent cell motility (GO:0001539)7.29554702
11regulation of cilium movement (GO:0003352)7.07881996
12cilium movement (GO:0003341)7.03783339
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.74865122
14negative regulation of inclusion body assembly (GO:0090084)6.71603445
15synaptonemal complex assembly (GO:0007130)6.49405034
16synaptonemal complex organization (GO:0070193)6.47394428
17sperm capacitation (GO:0048240)6.31871787
18single fertilization (GO:0007338)6.14935872
19spermatogenesis (GO:0007283)6.13365231
20male gamete generation (GO:0048232)6.10918518
21male meiosis (GO:0007140)5.94746860
22microtubule depolymerization (GO:0007019)5.92138912
23calcium ion-dependent exocytosis (GO:0017156)5.84384643
24piRNA metabolic process (GO:0034587)5.70862694
25organic cation transport (GO:0015695)5.69314932
26gamete generation (GO:0007276)5.61228461
27regulation of inclusion body assembly (GO:0090083)5.50228158
28chromosome condensation (GO:0030261)5.49754614
29fertilization (GO:0009566)5.47402081
30spermatid nucleus differentiation (GO:0007289)5.27491859
31DNA packaging (GO:0006323)5.21822526
32phosphatidylethanolamine biosynthetic process (GO:0006646)5.09157154
33sexual reproduction (GO:0019953)5.07179363
34germ cell development (GO:0007281)4.99569293
35cellular process involved in reproduction in multicellular organism (GO:0022412)4.98626921
36regulation of interferon-beta biosynthetic process (GO:0045357)4.96231363
37microtubule severing (GO:0051013)4.92976689
38cell recognition (GO:0008037)4.74676705
39phosphatidylethanolamine metabolic process (GO:0046337)4.73946411
40single strand break repair (GO:0000012)4.69784981
41rRNA methylation (GO:0031167)4.63018503
42cellular ketone body metabolic process (GO:0046950)4.58526693
43ventricular system development (GO:0021591)4.56945058
44multicellular organismal reproductive process (GO:0048609)4.42550637
45chromosome organization involved in meiosis (GO:0070192)4.41574003
46rRNA modification (GO:0000154)4.34957199
47glycerol ether metabolic process (GO:0006662)4.29317560
48regulation of microtubule-based movement (GO:0060632)4.23952409
49positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.23288409
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.16747235
51seminiferous tubule development (GO:0072520)4.15958381
52male meiosis I (GO:0007141)4.13215798
53ketone body metabolic process (GO:1902224)3.99740119
54left/right pattern formation (GO:0060972)3.95075787
55ether metabolic process (GO:0018904)3.93766513
56chaperone-mediated protein complex assembly (GO:0051131)3.87830840
57B cell receptor signaling pathway (GO:0050853)3.84145211
58meiotic nuclear division (GO:0007126)3.78113272
59positive regulation of histone deacetylation (GO:0031065)3.77655365
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.68489267
61DNA methylation involved in gamete generation (GO:0043046)3.59193435
62chromatin silencing (GO:0006342)3.57624232
63multicellular organismal development (GO:0007275)3.54334251
64protein K11-linked deubiquitination (GO:0035871)3.51228962
65protein targeting to Golgi (GO:0000042)3.50574523
66genitalia morphogenesis (GO:0035112)3.50309928
67regulation of Rab GTPase activity (GO:0032313)3.44325887
68positive regulation of Rab GTPase activity (GO:0032851)3.44325887
69membrane protein intracellular domain proteolysis (GO:0031293)3.44279403
70homeostasis of number of cells within a tissue (GO:0048873)3.43814493
71protein polyglutamylation (GO:0018095)3.42178604
72sequestering of actin monomers (GO:0042989)3.40655304
73mitotic sister chromatid cohesion (GO:0007064)3.40373379
74monoubiquitinated protein deubiquitination (GO:0035520)3.38080307
75antigen processing and presentation of endogenous antigen (GO:0019883)3.37194394
76retrograde transport, vesicle recycling within Golgi (GO:0000301)3.33182287
77regulation of spindle checkpoint (GO:0090231)3.31746639
78nucleosome disassembly (GO:0006337)3.29049957
79protein-DNA complex disassembly (GO:0032986)3.29049957
80establishment of protein localization to Golgi (GO:0072600)3.27413826
81nucleus organization (GO:0006997)3.25686053
82megakaryocyte development (GO:0035855)3.25165672
83meiosis I (GO:0007127)3.23431379
84regulation of germinal center formation (GO:0002634)3.22323395
85negative regulation of organelle assembly (GO:1902116)3.19241665
86positive thymic T cell selection (GO:0045059)3.13746931
87cellular response to exogenous dsRNA (GO:0071360)3.12089598
88glycolytic process (GO:0006096)3.10814962
89regulation of interferon-gamma biosynthetic process (GO:0045072)3.10430368
90mast cell degranulation (GO:0043303)3.10411007
91mast cell activation involved in immune response (GO:0002279)3.10411007
92interferon-gamma secretion (GO:0072643)3.07301339
93RNA localization (GO:0006403)3.05279894
94microtubule polymerization or depolymerization (GO:0031109)3.04490582
95NIK/NF-kappaB signaling (GO:0038061)3.03172532
96positive regulation of macrophage activation (GO:0043032)3.03147838
97activation of Rac GTPase activity (GO:0032863)3.00775489
98regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99802578
99GDP-mannose metabolic process (GO:0019673)2.98054131
100positive regulation of interferon-alpha production (GO:0032727)2.97770003
101polyamine biosynthetic process (GO:0006596)2.97530882
102RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93678110
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93678110
104regulation of monocyte differentiation (GO:0045655)2.92241218
105nuclear pore complex assembly (GO:0051292)2.88356040
106meiotic cell cycle (GO:0051321)2.86731114
107positive regulation of type 2 immune response (GO:0002830)2.85352031
108regulation of interferon-alpha production (GO:0032647)2.84576696
109protein refolding (GO:0042026)2.82896057
110negative regulation of B cell apoptotic process (GO:0002903)2.81633907
111mature B cell differentiation involved in immune response (GO:0002313)2.81573126
112negative regulation of gene expression, epigenetic (GO:0045814)2.81354773
113response to pheromone (GO:0019236)2.79797220
114centriole assembly (GO:0098534)2.79163337
115regulation of histone H3-K27 methylation (GO:0061085)2.77645766
116mast cell activation (GO:0045576)2.76752856
117activation of Rho GTPase activity (GO:0032862)2.75844890
118meiotic cell cycle process (GO:1903046)2.75360661
119negative regulation of granulocyte differentiation (GO:0030853)2.74815598
120microtubule-based movement (GO:0007018)2.74549988
121Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73780753
122gene silencing (GO:0016458)2.73683732
123regulation of cilium assembly (GO:1902017)2.71440437
124membrane depolarization during action potential (GO:0086010)2.70328546
125cellular response to heat (GO:0034605)2.69947386
126regulation of antigen processing and presentation (GO:0002577)2.69907440
127positive regulation of protein deacetylation (GO:0090312)2.65723756
128I-kappaB phosphorylation (GO:0007252)2.63837941
129positive regulation of antigen processing and presentation (GO:0002579)2.63778513
130thymic T cell selection (GO:0045061)2.63436669
131biotin metabolic process (GO:0006768)2.60425241
132negative regulation of cell size (GO:0045792)2.59875825
133lymph node development (GO:0048535)2.59771013
134immunoglobulin mediated immune response (GO:0016064)2.59482229
135positive regulation of B cell proliferation (GO:0030890)2.59309315
136carnitine transport (GO:0015879)2.58606229
137amino-acid betaine transport (GO:0015838)2.58606229
138chaperone mediated protein folding requiring cofactor (GO:0051085)2.58128965
139lysosome organization (GO:0007040)2.57939502
140lytic vacuole organization (GO:0080171)2.57939502
141regulation of centriole replication (GO:0046599)2.57122253
142regulated secretory pathway (GO:0045055)2.56708414
143positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56145802
144positive regulation of myotube differentiation (GO:0010831)2.55824845
145hydrogen peroxide biosynthetic process (GO:0050665)2.54399784
146negative thymic T cell selection (GO:0045060)2.52805512
147mature B cell differentiation (GO:0002335)2.51943217
148negative T cell selection (GO:0043383)2.51755036
149zinc ion homeostasis (GO:0055069)2.51598730
150positive regulation of T cell mediated cytotoxicity (GO:0001916)2.51420275
151protein localization to chromosome, centromeric region (GO:0071459)2.50847271
152carnitine transmembrane transport (GO:1902603)2.47930219
153protein localization to cilium (GO:0061512)2.46288940
154polyol catabolic process (GO:0046174)2.45564439
155regulation of histone H3-K9 methylation (GO:0051570)2.43615527
156gene silencing by RNA (GO:0031047)2.42852946
157lactate metabolic process (GO:0006089)2.39958774
158nuclear pore organization (GO:0006999)2.39749768
159peptidyl-lysine dimethylation (GO:0018027)2.39664680
160synapsis (GO:0007129)2.38406639
161histone exchange (GO:0043486)2.37734036
162RNA destabilization (GO:0050779)2.36740373
163cell wall macromolecule catabolic process (GO:0016998)12.9854530
164cell wall macromolecule metabolic process (GO:0044036)12.9854530
165sperm motility (GO:0030317)12.5575940
166acrosome reaction (GO:0007340)11.3659134
167fusion of sperm to egg plasma membrane (GO:0007342)11.1923115
168sperm-egg recognition (GO:0035036)10.4636675
169acrosome assembly (GO:0001675)10.4055998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.81331516
2EZH2_22144423_ChIP-Seq_EOC_Human5.20970195
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.95887304
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.94390784
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53701624
6MYC_22102868_ChIP-Seq_BL_Human3.35594274
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.35178154
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.27519494
9LXR_22292898_ChIP-Seq_THP-1_Human3.00933813
10VDR_21846776_ChIP-Seq_THP-1_Human2.90687266
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.89477537
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.56483461
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.39780145
14P68_20966046_ChIP-Seq_HELA_Human2.39652195
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.34132089
16BCL6_27268052_Chip-Seq_Bcells_Human2.33812491
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22113127
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13703252
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06093202
20SCL_19346495_ChIP-Seq_HPC-7_Human2.05649400
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03909255
22TCF7_22412390_ChIP-Seq_EML_Mouse1.98625106
23REST_21632747_ChIP-Seq_MESCs_Mouse1.92495140
24ZNF274_21170338_ChIP-Seq_K562_Hela1.90320260
25MAF_26560356_Chip-Seq_TH1_Human1.86830994
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85799133
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.83709441
28VDR_24763502_ChIP-Seq_THP-1_Human1.82016378
29RACK7_27058665_Chip-Seq_MCF-7_Human1.79632480
30KDM2B_26808549_Chip-Seq_DND41_Human1.79210047
31UTX_26944678_Chip-Seq_JUKART_Human1.78744943
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75586314
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75011915
34MAF_26560356_Chip-Seq_TH2_Human1.73542648
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71413429
36E2F1_20622854_ChIP-Seq_HELA_Human1.71127725
37KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69996911
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67523314
39P300_27268052_Chip-Seq_Bcells_Human1.66620353
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.65624329
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63072354
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62487112
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60159376
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58052421
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.56505203
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.56071741
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.55501634
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.53939497
49CTCF_21964334_Chip-Seq_Bcells_Human1.52507521
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.50850986
51TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.49501966
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48594298
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47664133
54TP63_22573176_ChIP-Seq_HFKS_Human1.47036729
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44735233
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.43379199
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43221687
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42369849
59SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40638250
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.40352099
61RAC3_21632823_ChIP-Seq_H3396_Human1.39923336
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37851074
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37677355
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.37193595
65FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36269283
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34669175
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34327289
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.34254937
69KDM2B_26808549_Chip-Seq_REH_Human1.33048991
70GATA1_19941826_ChIP-Seq_K562_Human1.32526639
71CTCF_21964334_ChIP-Seq_BJAB-B_Human1.32515818
72SPI1_23127762_ChIP-Seq_K562_Human1.31949820
73VDR_22108803_ChIP-Seq_LS180_Human1.31255997
74STAT1_17558387_ChIP-Seq_HELA_Human1.31194086
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30407981
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.29993109
77GATA3_21867929_ChIP-Seq_CD8_Mouse1.29977519
78MYB_26560356_Chip-Seq_TH1_Human1.29835750
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29797720
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29268316
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28453558
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.26823198
83ETS1_21867929_ChIP-Seq_TH2_Mouse1.26735418
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24929696
85CBP_20019798_ChIP-Seq_JUKART_Human1.24782041
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24782041
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24215317
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23947362
89TP53_22127205_ChIP-Seq_IMR90_Human1.23933322
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23815583
91NCOR1_26117541_ChIP-Seq_K562_Human1.23731438
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23384044
93SPI1_20517297_ChIP-Seq_HL60_Human1.23096594
94P53_21459846_ChIP-Seq_SAOS-2_Human1.22459349
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.22341230
96SA1_27219007_Chip-Seq_Bcells_Human1.22341009
97ERA_21632823_ChIP-Seq_H3396_Human1.20993062
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.20731960
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20399929
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20259937
101LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19891440
102ZNF263_19887448_ChIP-Seq_K562_Human1.19580503
103MYB_26560356_Chip-Seq_TH2_Human1.19503558
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19278239
105CREB1_26743006_Chip-Seq_LNCaP_Human1.19165250
106CIITA_25753668_ChIP-Seq_RAJI_Human1.17055685
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.16751412
108KDM5A_27292631_Chip-Seq_BREAST_Human1.16737683
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16691804
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16585607
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16127496
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15510864
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14860631
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13915689
115IRF8_21731497_ChIP-ChIP_J774_Mouse1.13828455
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13768814
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13527820
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12620168
119RUNX_20019798_ChIP-Seq_JUKART_Human1.12032624
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11869343
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11734509
122SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11094673
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10692435
124RARB_24833708_ChIP-Seq_LIVER_Mouse1.10338110
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09897935
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09532160
127RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09452601
128PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09278403
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09230247
130CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09178234
131FOXP1_21924763_ChIP-Seq_HESCs_Human1.08722313
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07559533
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07320752
134P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07071716
135TET1_21451524_ChIP-Seq_MESCs_Mouse1.07035051
136STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06479157
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06240958
138GATA3_21867929_ChIP-Seq_TH1_Mouse1.05921821
139TAL1_26923725_Chip-Seq_HPCs_Mouse1.05791902
140GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05484700
141REST_18959480_ChIP-ChIP_MESCs_Mouse1.05161777
142SPI1_26923725_Chip-Seq_HPCs_Mouse1.05045808
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04489466
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04138361
145SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03920851
146SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02869604
147CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02731700
148KDM2B_26808549_Chip-Seq_JURKAT_Human1.01581036
149CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01110009
150RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00886828
151JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00841857
152NFE2_27457419_Chip-Seq_LIVER_Mouse1.00082044
153GF1_26923725_Chip-Seq_HPCs_Mouse0.99923877
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99885138
155SOX9_26525672_Chip-Seq_HEART_Mouse0.99741661
156FLI1_21867929_ChIP-Seq_TH2_Mouse0.99408194
157NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99070346
158PHF8_20622854_ChIP-Seq_HELA_Human0.98519356
159KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96906610
160BCOR_27268052_Chip-Seq_Bcells_Human0.96897775
161RARA_24833708_ChIP-Seq_LIVER_Mouse0.96534838
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.96158772
163MYC_27129775_Chip-Seq_CORNEA_Mouse0.95979547
164SMC4_20622854_ChIP-Seq_HELA_Human0.95463059
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93497705
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93497705
167SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92342701
168CTCF_27219007_Chip-Seq_Bcells_Human0.92194918
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.91364616
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90941142
171RARB_27405468_Chip-Seq_BRAIN_Mouse0.89598234
172RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89329312
173NANOG_18555785_Chip-Seq_ESCs_Mouse0.88980047
174SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88242296
175ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87975289
176OCT4_19829295_ChIP-Seq_ESCs_Human0.87473759
177NFYB_21822215_ChIP-Seq_K562_Human0.86254429
178E2F7_22180533_ChIP-Seq_HELA_Human0.86080769
179KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85854935
180ESET_19884257_ChIP-Seq_ESCs_Mouse0.85447315
181RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85040580
182CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84423502
183CTCF_20526341_ChIP-Seq_ESCs_Human0.84196754
184TBL1_22424771_ChIP-Seq_293T_Human0.83024857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.46094746
2MP0001929_abnormal_gametogenesis4.87351125
3MP0008877_abnormal_DNA_methylation3.46053754
4MP0003172_abnormal_lysosome_physiology3.23547427
5MP0003283_abnormal_digestive_organ3.07411407
6MP0002161_abnormal_fertility/fecundity3.05859678
7MP0005310_abnormal_salivary_gland3.04528912
8MP0005451_abnormal_body_composition3.04180901
9MP0002210_abnormal_sex_determination2.93504811
10MP0001348_abnormal_lacrimal_gland2.80634420
11MP0005083_abnormal_biliary_tract2.67039371
12MP0001145_abnormal_male_reproductive2.55832326
13MP0001835_abnormal_antigen_presentation2.53895225
14MP0001800_abnormal_humoral_immune2.52232758
15MP0005670_abnormal_white_adipose2.35845143
16MP0005387_immune_system_phenotype2.34305350
17MP0001790_abnormal_immune_system2.34305350
18MP0004859_abnormal_synaptic_plasticity2.25508760
19MP0000653_abnormal_sex_gland2.20349850
20MP0002138_abnormal_hepatobiliary_system2.20289465
21MP0005671_abnormal_response_to2.17779556
22MP0003763_abnormal_thymus_physiology2.16617295
23MP0004233_abnormal_muscle_weight2.15974747
24MP0000678_abnormal_parathyroid_gland2.14888393
25MP0002452_abnormal_antigen_presenting2.07769942
26MP0002723_abnormal_immune_serum2.01198462
27MP0005410_abnormal_fertilization14.5514931
28MP0001873_stomach_inflammation1.98811336
29MP0002653_abnormal_ependyma_morphology1.86767460
30MP0002420_abnormal_adaptive_immunity1.85309269
31MP0009384_cardiac_valve_regurgitation1.84862381
32MP0001819_abnormal_immune_cell1.83118378
33MP0005000_abnormal_immune_tolerance1.82073691
34MP0003436_decreased_susceptibility_to1.81985977
35MP0005058_abnormal_lysosome_morphology1.75147303
36MP0005025_abnormal_response_to1.72428816
37MP0009046_muscle_twitch1.70576124
38MP0002160_abnormal_reproductive_system1.67939598
39MP0002398_abnormal_bone_marrow1.67308251
40MP0000685_abnormal_immune_system1.59868760
41MP0004947_skin_inflammation1.56015630
42MP0002148_abnormal_hypersensitivity_rea1.50495653
43MP0002166_altered_tumor_susceptibility1.50077948
44MP0000689_abnormal_spleen_morphology1.49619186
45MP0002396_abnormal_hematopoietic_system1.46634573
46MP0003191_abnormal_cellular_cholesterol1.46335980
47MP0000716_abnormal_immune_system1.43063959
48MP0005623_abnormal_meninges_morphology1.43044446
49MP0003183_abnormal_peptide_metabolism1.41647614
50MP0000569_abnormal_digit_pigmentation1.39384878
51MP0002419_abnormal_innate_immunity1.37404611
52MP0003635_abnormal_synaptic_transmissio1.33949240
53MP0010234_abnormal_vibrissa_follicle1.31744003
54MP0002722_abnormal_immune_system1.30312595
55MP0009785_altered_susceptibility_to1.29245866
56MP0010094_abnormal_chromosome_stability1.24061513
57MP0002429_abnormal_blood_cell1.23972358
58MP0001968_abnormal_touch/_nociception1.17633104
59MP0000003_abnormal_adipose_tissue1.15078366
60MP0001764_abnormal_homeostasis1.14702263
61MP0002736_abnormal_nociception_after1.13797295
62MP0004270_analgesia1.13661428
63MP0003111_abnormal_nucleus_morphology1.13259015
64MP0009840_abnormal_foam_cell1.10194962
65MP0000465_gastrointestinal_hemorrhage1.08926411
66MP0008569_lethality_at_weaning1.08909317
67MP0002006_tumorigenesis1.07833948
68MP0002405_respiratory_system_inflammati1.06731039
69MP0008058_abnormal_DNA_repair1.06569295
70MP0004264_abnormal_extraembryonic_tissu1.06353510
71MP0003718_maternal_effect1.03197586
72MP0003646_muscle_fatigue1.02953708
73MP0004811_abnormal_neuron_physiology1.02609388
74MP0010155_abnormal_intestine_physiology1.00757521
75MP0008469_abnormal_protein_level1.00022427
76MP0009333_abnormal_splenocyte_physiolog0.99963744
77MP0002254_reproductive_system_inflammat0.99393272
78MP0001845_abnormal_inflammatory_respons0.99132654
79MP0002063_abnormal_learning/memory/cond0.99034997
80MP0003303_peritoneal_inflammation0.97319366
81MP0000703_abnormal_thymus_morphology0.95888546
82MP0002064_seizures0.95714180
83MP0000681_abnormal_thyroid_gland0.95106739
84MP0002234_abnormal_pharynx_morphology0.92575233
85MP0001765_abnormal_ion_homeostasis0.92033009
86MP0008961_abnormal_basal_metabolism0.91562793
87MP0003880_abnormal_central_pattern0.90828866
88MP0009278_abnormal_bone_marrow0.90078292
89MP0000015_abnormal_ear_pigmentation0.89879876
90MP0002009_preneoplasia0.87220730
91MP0002132_abnormal_respiratory_system0.87073945
92MP0005375_adipose_tissue_phenotype0.86210303
93MP0010307_abnormal_tumor_latency0.86003088
94MP0005389_reproductive_system_phenotype0.85618268
95MP0001533_abnormal_skeleton_physiology0.84890709
96MP0000470_abnormal_stomach_morphology0.84196650
97MP0009745_abnormal_behavioral_response0.83878815
98MP0000733_abnormal_muscle_development0.83804019
99MP0003329_amyloid_beta_deposits0.83580976
100MP0001984_abnormal_olfaction0.83078482
101MP0005423_abnormal_somatic_nervous0.82779159
102MP0003879_abnormal_hair_cell0.81732870
103MP0002572_abnormal_emotion/affect_behav0.79046935
104MP0004510_myositis0.76536841
105MP0000538_abnormal_urinary_bladder0.76373817
106MP0004133_heterotaxia0.75519794
107MP0001486_abnormal_startle_reflex0.74909500
108MP0008004_abnormal_stomach_pH0.74368643
109MP0003787_abnormal_imprinting0.74209580
110MP0002136_abnormal_kidney_physiology0.73769794
111MP0000613_abnormal_salivary_gland0.73760186
112MP0000249_abnormal_blood_vessel0.72839005
113MP0003866_abnormal_defecation0.71037639
114MP0005360_urolithiasis0.71003045
115MP0002734_abnormal_mechanical_nocicepti0.69800166
116MP0002272_abnormal_nervous_system0.69605254
117MP0003115_abnormal_respiratory_system0.69068892
118MP0002152_abnormal_brain_morphology0.68719032
119MP0004381_abnormal_hair_follicle0.68528792
120MP0001730_embryonic_growth_arrest0.68433724
121MP0009643_abnormal_urine_homeostasis0.67551781
122MP0002796_impaired_skin_barrier0.67152406
123MP0005075_abnormal_melanosome_morpholog0.65710008
124MP0000313_abnormal_cell_death0.64037281
125MP0003861_abnormal_nervous_system0.62413728
126MP0005397_hematopoietic_system_phenotyp0.62412987
127MP0001545_abnormal_hematopoietic_system0.62412987
128MP0000367_abnormal_coat/_hair0.61848678
129MP0000955_abnormal_spinal_cord0.61101985
130MP0003453_abnormal_keratinocyte_physiol0.60892248
131MP0001440_abnormal_grooming_behavior0.60335939
132MP0005647_abnormal_sex_gland0.60274648
133MP0003786_premature_aging0.60183808
134MP0002269_muscular_atrophy0.59220325
135MP0008770_decreased_survivor_rate0.58685552
136MP0002282_abnormal_trachea_morphology0.58045208
137MP0008995_early_reproductive_senescence0.57156345
138MP0000609_abnormal_liver_physiology0.57143504
139MP0004782_abnormal_surfactant_physiolog0.56666570
140MP0002735_abnormal_chemical_nociception0.56384293
141MP0002084_abnormal_developmental_patter0.55848284
142MP0005319_abnormal_enzyme/_coenzyme0.55754634
143MP0002882_abnormal_neuron_morphology0.53803092
144MP0000751_myopathy0.52974539
145MP0001849_ear_inflammation0.52486273
146MP0002067_abnormal_sensory_capabilities0.51124933
147MP0000358_abnormal_cell_content/0.51005408
148MP0002184_abnormal_innervation0.49913290
149MP0002066_abnormal_motor_capabilities/c0.47401438
150MP0004808_abnormal_hematopoietic_stem0.47330817
151MP0004145_abnormal_muscle_electrophysio0.47283254
152MP0001293_anophthalmia0.47158004
153MP0003633_abnormal_nervous_system0.44943148
154MP0002557_abnormal_social/conspecific_i0.44815671
155MP0003631_nervous_system_phenotype0.44730765
156MP0003699_abnormal_female_reproductive0.44253064
157MP0000534_abnormal_ureter_morphology0.43003710
158MP0000462_abnormal_digestive_system0.41866920
159MP0005666_abnormal_adipose_tissue0.40114623
160MP0005645_abnormal_hypothalamus_physiol0.39412491
161MP0000604_amyloidosis0.38772007
162MP0003878_abnormal_ear_physiology0.38632708
163MP0005377_hearing/vestibular/ear_phenot0.38632708
164MP0003632_abnormal_nervous_system0.38447937
165MP0003077_abnormal_cell_cycle0.38123908
166MP0010769_abnormal_survival0.36855221
167MP0004134_abnormal_chest_morphology0.36752986
168MP0010768_mortality/aging0.36707636
169MP0002873_normal_phenotype0.36634805
170MP0002169_no_abnormal_phenotype0.36591521
171MP0004197_abnormal_fetal_growth/weight/0.36491513
172MP0005076_abnormal_cell_differentiation0.35537994
173MP0002085_abnormal_embryonic_tissue0.35501237
174MP0005391_vision/eye_phenotype0.34685530
175MP0003705_abnormal_hypodermis_morpholog0.34666201
176MP0003045_fibrosis0.34496776
177MP0005174_abnormal_tail_pigmentation0.33123085
178MP0005253_abnormal_eye_physiology0.32778864
179MP0008872_abnormal_physiological_respon0.32756509
180MP0001672_abnormal_embryogenesis/_devel0.32701612

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.23434328
2Abnormal respiratory motile cilium morphology (HP:0005938)8.23434328
3Abnormal respiratory motile cilium physiology (HP:0012261)8.12153976
4Rhinitis (HP:0012384)6.59598567
5Chronic bronchitis (HP:0004469)6.45920914
6Infertility (HP:0000789)6.40338396
7Abnormal ciliary motility (HP:0012262)6.16986628
8Agammaglobulinemia (HP:0004432)5.84654210
9Nasal polyposis (HP:0100582)5.53543790
10Severe visual impairment (HP:0001141)5.21301116
11Cellulitis (HP:0100658)5.03564966
12Broad face (HP:0000283)4.46109941
13Recurrent pneumonia (HP:0006532)4.45003040
14Abnormality of the nasal mucosa (HP:0000433)4.39794901
15Male infertility (HP:0003251)4.30518196
16Eczematoid dermatitis (HP:0000976)4.18274389
17Bronchitis (HP:0012387)3.86636082
18Cervical subluxation (HP:0003308)3.86500542
19Bronchiectasis (HP:0002110)3.84986136
20Nephronophthisis (HP:0000090)3.83523304
21Obstructive lung disease (HP:0006536)3.67935311
22Chronic obstructive pulmonary disease (HP:0006510)3.67935311
23Meningitis (HP:0001287)3.50120440
24J-shaped sella turcica (HP:0002680)3.42148771
25Gastrointestinal stroma tumor (HP:0100723)3.31409296
26Recurrent lower respiratory tract infections (HP:0002783)3.25002344
27Hypertensive crisis (HP:0100735)3.22421646
28Abnormal spermatogenesis (HP:0008669)3.19867710
29Recurrent otitis media (HP:0000403)3.12727072
30Gastrointestinal inflammation (HP:0004386)3.05126805
31Mediastinal lymphadenopathy (HP:0100721)2.94835066
32Amelogenesis imperfecta (HP:0000705)2.93922751
33Papilloma (HP:0012740)2.93652648
34Verrucae (HP:0200043)2.93652648
35Hyperthyroidism (HP:0000836)2.88988274
36Colitis (HP:0002583)2.85928804
37Impulsivity (HP:0100710)2.82766905
38Inflammation of the large intestine (HP:0002037)2.82357102
39Recurrent bacterial skin infections (HP:0005406)2.82255916
40Attenuation of retinal blood vessels (HP:0007843)2.79481275
41Abnormality of the renal medulla (HP:0100957)2.77105021
42Osteomyelitis (HP:0002754)2.70357088
43Recurrent fungal infections (HP:0002841)2.68673988
44Abnormality of macrophages (HP:0004311)2.68193117
45Prolonged bleeding time (HP:0003010)2.60492304
46Recurrent sinusitis (HP:0011108)2.59658529
47Recurrent abscess formation (HP:0002722)2.58396916
48Heterotopia (HP:0002282)2.55115667
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51978869
50Tubular atrophy (HP:0000092)2.51057429
51Recurrent gram-negative bacterial infections (HP:0005420)2.48823377
52Gingivitis (HP:0000230)2.46369227
53Dysostosis multiplex (HP:0000943)2.45744981
54Truncus arteriosus (HP:0001660)2.45561745
55Seborrheic dermatitis (HP:0001051)2.44575494
56Hypoplasia of the thymus (HP:0000778)2.44212296
57Resting tremor (HP:0002322)2.37003457
58Chronic sinusitis (HP:0011109)2.34399443
59Urinary glycosaminoglycan excretion (HP:0003541)2.33637875
60Mucopolysacchariduria (HP:0008155)2.33637875
61Molar tooth sign on MRI (HP:0002419)2.33557325
62Abnormality of midbrain morphology (HP:0002418)2.33557325
63Tubulointerstitial nephritis (HP:0001970)2.32436549
64Aplasia/Hypoplasia of the earlobes (HP:0009906)2.29324534
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26048127
66Abnormality of polysaccharide metabolism (HP:0011012)2.26048127
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26048127
68Obstructive sleep apnea (HP:0002870)2.23047562
69Hypergonadotropic hypogonadism (HP:0000815)2.22498252
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15249169
71Recurrent bronchitis (HP:0002837)2.13779528
72Abnormality of dental color (HP:0011073)2.12739780
73Bony spicule pigmentary retinopathy (HP:0007737)2.11834813
74Hypoparathyroidism (HP:0000829)2.11008092
75Sepsis (HP:0100806)2.10286996
76Aplasia/Hypoplasia of the thymus (HP:0010515)2.09322834
77Hepatosplenomegaly (HP:0001433)2.09265109
78Impaired smooth pursuit (HP:0007772)2.07712748
79Cholecystitis (HP:0001082)2.07444407
80Abnormal gallbladder physiology (HP:0012438)2.07444407
81Hyperkalemia (HP:0002153)2.06317135
82Restrictive lung disease (HP:0002091)2.06070226
83Abnormality of ocular smooth pursuit (HP:0000617)2.04201833
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02315286
85Dehydration (HP:0001944)2.01528914
86Progressive sensorineural hearing impairment (HP:0000408)2.00830577
87Recurrent viral infections (HP:0004429)2.00320576
88Absent/shortened dynein arms (HP:0200106)12.2388327
89Dynein arm defect of respiratory motile cilia (HP:0012255)12.2388327
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.3925493
91Hemorrhage of the eye (HP:0011885)1.99429039
92Choroideremia (HP:0001139)1.98415034
93Chronic hepatic failure (HP:0100626)1.97772820
94Emphysema (HP:0002097)1.96536556
95Spastic tetraparesis (HP:0001285)1.95619581
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.95444586
97Vasculitis (HP:0002633)1.95210417
98Abnormality of the costochondral junction (HP:0000919)1.94334549
99Prolonged neonatal jaundice (HP:0006579)1.94191144
100Short ribs (HP:0000773)1.94140416
101Progressive cerebellar ataxia (HP:0002073)1.93436760
102Tubulointerstitial abnormality (HP:0001969)1.92044179
103Abnormality of the lower motor neuron (HP:0002366)1.91335746
104Azoospermia (HP:0000027)1.88960660
105Hemiparesis (HP:0001269)1.88361699
106Thin bony cortex (HP:0002753)1.88320691
107Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.87941090
108Petechiae (HP:0000967)1.86575428
109Enlarged epiphyses (HP:0010580)1.86447748
110Biconcave vertebral bodies (HP:0004586)1.85055352
111Progressive neurologic deterioration (HP:0002344)1.84894637
112Menstrual irregularities (HP:0000858)1.84435298
113Spastic paraparesis (HP:0002313)1.82112489
114Bundle branch block (HP:0011710)1.81069312
115Dysmetric saccades (HP:0000641)1.81068314
116Flattened epiphyses (HP:0003071)1.79693509
117Gonadotropin excess (HP:0000837)1.79345614
118Skin ulcer (HP:0200042)1.79335693
119Abnormality of T cell physiology (HP:0011840)1.78308049
120Pulmonary fibrosis (HP:0002206)1.78049264
121Alveolar cell carcinoma (HP:0006519)1.77752888
122Impaired vibration sensation in the lower limbs (HP:0002166)1.77181496
123Cone-rod dystrophy (HP:0000548)1.76533834
124Medial flaring of the eyebrow (HP:0010747)1.74812922
125Coxa valga (HP:0002673)1.74739488
126Pili torti (HP:0003777)1.73577792
127Recurrent skin infections (HP:0001581)1.71273477
128Dyschromatopsia (HP:0007641)1.71246263
129Abnormal drinking behavior (HP:0030082)1.68505328
130Polydipsia (HP:0001959)1.68505328
131Stage 5 chronic kidney disease (HP:0003774)1.68096178
132Renovascular hypertension (HP:0100817)1.66508315
133Congenital malformation of the right heart (HP:0011723)1.63323887
134Double outlet right ventricle (HP:0001719)1.63323887
135Neoplasm of the heart (HP:0100544)1.63202554
136Absent frontal sinuses (HP:0002688)1.62537795
137Truncal obesity (HP:0001956)1.59137661
138Postural instability (HP:0002172)1.57661110
139Broad distal phalanx of finger (HP:0009836)1.56863313
140Asymmetric septal hypertrophy (HP:0001670)1.55301714
141Bell-shaped thorax (HP:0001591)1.53380399
142Cerebral inclusion bodies (HP:0100314)1.53244198
143Absent epiphyses (HP:0010577)1.53193481
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53193481
145Hyperacusis (HP:0010780)1.53093560
146Postaxial foot polydactyly (HP:0001830)1.50457384
147Deformed sella turcica (HP:0002681)1.48050711
148Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.47948880
149Abnormality of saccadic eye movements (HP:0000570)1.47889988
150Tubulointerstitial fibrosis (HP:0005576)1.42476950
151Insomnia (HP:0100785)1.41590555
152Decreased central vision (HP:0007663)1.41375968
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.40391176
154Loss of speech (HP:0002371)1.40267491
155Oculomotor apraxia (HP:0000657)1.39867257
156Difficulty climbing stairs (HP:0003551)1.38608283
157Neurofibrillary tangles (HP:0002185)1.37513154
158Gaze-evoked nystagmus (HP:0000640)1.36236120
159Abnormality of renal excretion (HP:0011036)1.35303823
160Supranuclear gaze palsy (HP:0000605)1.35245159
161Urinary urgency (HP:0000012)1.35084337
162Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.33552628
163Short 4th metacarpal (HP:0010044)1.33552628
164Urinary bladder sphincter dysfunction (HP:0002839)1.32271860
165Myokymia (HP:0002411)1.30766549
166Abnormality of the epiphyses of the hand (HP:0005924)1.30202524
167Facial cleft (HP:0002006)1.29696998
168Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29678777
169Congenital hepatic fibrosis (HP:0002612)1.27014087
170Abnormality of permanent molar morphology (HP:0011071)1.26301754
171Abnormality of the dental root (HP:0006486)1.26301754
172Taurodontia (HP:0000679)1.26301754
173Neuronal loss in central nervous system (HP:0002529)1.25868420
174Postaxial hand polydactyly (HP:0001162)1.23902235
175Exercise-induced myalgia (HP:0003738)1.23690736
176Global brain atrophy (HP:0002283)1.22445260
177Aplasia/Hypoplasia of the lens (HP:0008063)1.21516548
178Annular pancreas (HP:0001734)1.20827738
179Focal seizures (HP:0007359)1.20416506
180EMG: neuropathic changes (HP:0003445)1.20263534
181Megalocornea (HP:0000485)1.19184647
182Decreased electroretinogram (ERG) amplitude (HP:0000654)1.19053369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.44594750
2PDK37.44594750
3TESK15.81927916
4PRKD35.20523288
5PDK24.60328960
6ICK4.55753198
7ARAF3.26168055
8PIM22.96689917
9MAP3K112.28282392
10PLK42.21536858
11ERN12.15741498
12PNCK2.13586258
13STK382.08254737
14BCKDK2.03448893
15GRK61.93661533
16PTK2B1.87877007
17NEK21.87372264
18MAP4K11.81058627
19PRKD21.80555851
20SIK11.68993156
21TLK11.68361901
22MST1R1.60234083
23WNK41.58558328
24EEF2K1.58548958
25MAP3K131.56621452
26BRAF1.55355850
27EPHA21.55290445
28BMPR21.54513054
29IRAK41.54374101
30IKBKB1.50833418
31BLK1.44633669
32MAP2K31.42653139
33TAOK21.35004852
34RAF11.34940727
35TNK21.32326641
36KDR1.29333791
37PDK11.29242640
38MAP2K21.28459818
39IRAK31.28335590
40TYRO31.28270906
41DYRK1B1.26931585
42MAPK111.26418910
43SMG11.24969691
44PKN21.24960910
45TBK11.23460979
46MAPK151.22160787
47AKT31.21725505
48ZAP701.16595095
49CDC71.12247536
50RPS6KC11.11664405
51RPS6KL11.11664405
52TRIB31.02720466
53RIPK41.02701762
54STK391.01277726
55CAMK1G1.01035651
56MAPKAPK31.00550488
57RPS6KB21.00445828
58NTRK21.00175879
59RPS6KA60.98916333
60WNK10.98837211
61TAOK30.96778611
62NEK60.96525378
63CDK70.95132798
64JAK30.91972025
65KIT0.91363418
66CAMKK10.89404973
67MAP3K100.89279957
68MAP2K10.88882777
69NME20.88487874
70ILK0.87916695
71BTK0.85744363
72MAP3K10.83882194
73BRD40.82510442
74SYK0.82116308
75MAP3K30.81801429
76MAP3K80.80653661
77PAK60.80421919
78PDPK10.77382414
79INSRR0.74174150
80TESK20.73351316
81PRKD10.69022495
82EPHA40.68150880
83NTRK30.66971369
84PASK0.66241193
85DAPK30.65760882
86MAP3K40.65183239
87MAP3K90.64351499
88CHEK20.64049915
89CSF1R0.62283147
90TYK20.61699176
91MAPKAPK20.61441543
92JAK10.60352691
93IKBKE0.59620215
94LCK0.59073966
95PRKCG0.58951953
96CHUK0.56847409
97PINK10.55565356
98DYRK30.54914677
99LYN0.54442078
100TTK0.53726450
101MAP3K60.53518370
102CDK120.52609038
103DAPK20.51643846
104PRKCI0.51221350
105CDK150.50685966
106CHEK10.50118879
107LMTK20.49806715
108PKN10.49352303
109MTOR0.49006316
110ALK0.47427296
111PRPF4B0.47077720
112DMPK0.46532163
113CDK180.45899761
114SIK20.45311200
115MAPK120.43835708
116CDK11A0.42961289
117TAOK10.42394373
118ATR0.42020207
119MARK20.42004918
120MAP3K140.41933677
121PRKG20.41843214
122CDK140.40176133
123RPS6KA50.39942553
124ATM0.39813957
125MINK10.39166534
126BRSK10.37972320
127MUSK0.37273788
128PAK20.37077084
129PAK10.36202288
130NTRK10.31494856
131RIPK10.31251467
132LATS20.29313725
133STK30.29160544
134PRKAA10.28460717
135CAMK2B0.27711712
136CDK20.27112992
137PAK40.26917323
138CCNB10.26503889
139CDK50.26232365
140UHMK10.25182020
141BMX0.24143084
142STK110.23556094
143MAPKAPK50.22141264
144RPS6KA10.22136700
145GSK3B0.21958672
146CDK60.20439082
147MARK10.20412977
148DDR20.20226920
149PRKCZ0.20008879
150IRAK10.19809752
151MAPK80.19574445
152DAPK10.19537892
153PRKCH0.19454052
154MAPK100.19055709
155CDK10.18807982
156RPS6KA30.18012662
157RPS6KB10.16710684
158CDK40.16064511
159PRKDC0.15601559
160CSNK1D0.14909969
161PLK10.14438743
162CDC42BPA0.14242163
163PRKCB0.13518273
164CAMK10.13284360
165AURKA0.13169929
166IRAK20.12494296
167CSNK1E0.11980257
168SCYL20.11843302
169RPS6KA20.11555106
170CAMK1D0.09935077
171MAP2K60.09183517
172PIM10.08874662
173KSR20.08732493
174SGK10.08223466

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.60324624
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.35984824
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.17490611
4Primary immunodeficiency_Homo sapiens_hsa053403.08355262
5Allograft rejection_Homo sapiens_hsa053302.88385491
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.85388650
7Autoimmune thyroid disease_Homo sapiens_hsa053202.68432204
8Graft-versus-host disease_Homo sapiens_hsa053322.53172683
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47006453
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.42464614
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39298945
12Vitamin B6 metabolism_Homo sapiens_hsa007502.35678912
13Acute myeloid leukemia_Homo sapiens_hsa052212.34383415
14Glucagon signaling pathway_Homo sapiens_hsa049222.33983753
15Amphetamine addiction_Homo sapiens_hsa050312.25303842
16Oocyte meiosis_Homo sapiens_hsa041142.20877538
17Type I diabetes mellitus_Homo sapiens_hsa049402.09554077
18Asthma_Homo sapiens_hsa053102.05610945
19Pyruvate metabolism_Homo sapiens_hsa006201.91973050
20Synaptic vesicle cycle_Homo sapiens_hsa047211.86689382
21Leishmaniasis_Homo sapiens_hsa051401.86553966
22Systemic lupus erythematosus_Homo sapiens_hsa053221.84793812
23Long-term potentiation_Homo sapiens_hsa047201.83534430
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83277628
25Viral myocarditis_Homo sapiens_hsa054161.73647939
26Sulfur relay system_Homo sapiens_hsa041221.72822408
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.72116485
28Dorso-ventral axis formation_Homo sapiens_hsa043201.67263054
29Alcoholism_Homo sapiens_hsa050341.52238362
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48861592
31Insulin secretion_Homo sapiens_hsa049111.46679540
32Herpes simplex infection_Homo sapiens_hsa051681.44513426
33Influenza A_Homo sapiens_hsa051641.43180710
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.41223104
35Nicotine addiction_Homo sapiens_hsa050331.41194254
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41072225
37Salivary secretion_Homo sapiens_hsa049701.39420723
38Estrogen signaling pathway_Homo sapiens_hsa049151.36624585
39Linoleic acid metabolism_Homo sapiens_hsa005911.36084086
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35109769
41Toxoplasmosis_Homo sapiens_hsa051451.28545361
42Renin secretion_Homo sapiens_hsa049241.28447234
43mRNA surveillance pathway_Homo sapiens_hsa030151.28090184
44Osteoclast differentiation_Homo sapiens_hsa043801.27000601
45Circadian entrainment_Homo sapiens_hsa047131.24355868
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.24165132
47Gastric acid secretion_Homo sapiens_hsa049711.23582755
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22944312
49Hematopoietic cell lineage_Homo sapiens_hsa046401.22809549
50Other glycan degradation_Homo sapiens_hsa005111.22349454
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20635533
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.19142515
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19109937
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18542600
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18453015
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17319182
57Glutamatergic synapse_Homo sapiens_hsa047241.17057221
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15090306
59Olfactory transduction_Homo sapiens_hsa047401.14975615
60Glycerolipid metabolism_Homo sapiens_hsa005611.14015538
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13398608
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10585276
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06769914
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06739118
65Pentose phosphate pathway_Homo sapiens_hsa000301.06322340
66cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05804648
67Non-small cell lung cancer_Homo sapiens_hsa052231.05252158
68RNA transport_Homo sapiens_hsa030131.04946217
69Lysosome_Homo sapiens_hsa041421.04179841
70Central carbon metabolism in cancer_Homo sapiens_hsa052301.03361846
71Tuberculosis_Homo sapiens_hsa051521.02822549
72Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00802171
73Selenocompound metabolism_Homo sapiens_hsa004501.00704430
74Mineral absorption_Homo sapiens_hsa049781.00449908
75Measles_Homo sapiens_hsa051621.00393828
76Fanconi anemia pathway_Homo sapiens_hsa034601.00303392
77Fructose and mannose metabolism_Homo sapiens_hsa000510.99560758
78Calcium signaling pathway_Homo sapiens_hsa040200.99097976
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.98559472
80Basal transcription factors_Homo sapiens_hsa030220.98026062
81Cardiac muscle contraction_Homo sapiens_hsa042600.97842347
82Bladder cancer_Homo sapiens_hsa052190.94527049
83Thyroid hormone synthesis_Homo sapiens_hsa049180.93479731
84Epstein-Barr virus infection_Homo sapiens_hsa051690.93166168
85Propanoate metabolism_Homo sapiens_hsa006400.91581441
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90524889
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89989190
88Type II diabetes mellitus_Homo sapiens_hsa049300.89518852
89Base excision repair_Homo sapiens_hsa034100.89220195
90Dopaminergic synapse_Homo sapiens_hsa047280.88609537
91Hedgehog signaling pathway_Homo sapiens_hsa043400.88524951
92Hepatitis C_Homo sapiens_hsa051600.88417547
93cAMP signaling pathway_Homo sapiens_hsa040240.87986856
94VEGF signaling pathway_Homo sapiens_hsa043700.87970881
95Inositol phosphate metabolism_Homo sapiens_hsa005620.87942831
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86650130
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85636097
98T cell receptor signaling pathway_Homo sapiens_hsa046600.84549492
99Morphine addiction_Homo sapiens_hsa050320.82968946
100DNA replication_Homo sapiens_hsa030300.80687755
101Collecting duct acid secretion_Homo sapiens_hsa049660.80637950
102TNF signaling pathway_Homo sapiens_hsa046680.79651558
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79267369
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77922821
105Taste transduction_Homo sapiens_hsa047420.76643724
106Endocytosis_Homo sapiens_hsa041440.73926645
107Carbon metabolism_Homo sapiens_hsa012000.73470117
108Oxytocin signaling pathway_Homo sapiens_hsa049210.72796399
109Pancreatic secretion_Homo sapiens_hsa049720.72001602
110Hepatitis B_Homo sapiens_hsa051610.71560682
111HTLV-I infection_Homo sapiens_hsa051660.69975018
112N-Glycan biosynthesis_Homo sapiens_hsa005100.69304461
113Bile secretion_Homo sapiens_hsa049760.68801273
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67942478
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66876684
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66700943
117Cocaine addiction_Homo sapiens_hsa050300.66102016
118Phenylalanine metabolism_Homo sapiens_hsa003600.66079471
119Apoptosis_Homo sapiens_hsa042100.65962162
120AMPK signaling pathway_Homo sapiens_hsa041520.65772466
121Renin-angiotensin system_Homo sapiens_hsa046140.65592123
122Staphylococcus aureus infection_Homo sapiens_hsa051500.65305573
123Chronic myeloid leukemia_Homo sapiens_hsa052200.63997156
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.63894004
125Viral carcinogenesis_Homo sapiens_hsa052030.63431135
126Biosynthesis of amino acids_Homo sapiens_hsa012300.63051028
127Cell cycle_Homo sapiens_hsa041100.62548694
128mTOR signaling pathway_Homo sapiens_hsa041500.62002911
129Platelet activation_Homo sapiens_hsa046110.61074322
130PPAR signaling pathway_Homo sapiens_hsa033200.60777435
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.59023493
132Lysine degradation_Homo sapiens_hsa003100.57637145
133Purine metabolism_Homo sapiens_hsa002300.57117834
134Glioma_Homo sapiens_hsa052140.55805182
135Ether lipid metabolism_Homo sapiens_hsa005650.55677527
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55664841
137Thyroid cancer_Homo sapiens_hsa052160.55328442
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.55087623
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52842092
140B cell receptor signaling pathway_Homo sapiens_hsa046620.52223565
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.50195822
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49277827
143GABAergic synapse_Homo sapiens_hsa047270.47976493
144Antigen processing and presentation_Homo sapiens_hsa046120.46434175
145Rheumatoid arthritis_Homo sapiens_hsa053230.45475442
146Wnt signaling pathway_Homo sapiens_hsa043100.44684288
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.44264917
148Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43424825
149MAPK signaling pathway_Homo sapiens_hsa040100.42792468
150ABC transporters_Homo sapiens_hsa020100.41645834
151Insulin signaling pathway_Homo sapiens_hsa049100.40595099
152Cholinergic synapse_Homo sapiens_hsa047250.40466959
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40140085
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39925824
155Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39524592
156HIF-1 signaling pathway_Homo sapiens_hsa040660.38682120
157Mismatch repair_Homo sapiens_hsa034300.38616943
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.38231259
159Shigellosis_Homo sapiens_hsa051310.37623179
160Pyrimidine metabolism_Homo sapiens_hsa002400.36186403
161Legionellosis_Homo sapiens_hsa051340.36101806
162Homologous recombination_Homo sapiens_hsa034400.35010315
163Malaria_Homo sapiens_hsa051440.34198510
164Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33675203
165Fat digestion and absorption_Homo sapiens_hsa049750.32976902
166African trypanosomiasis_Homo sapiens_hsa051430.32600987
167Insulin resistance_Homo sapiens_hsa049310.32173282
168Choline metabolism in cancer_Homo sapiens_hsa052310.31897735
169Fatty acid metabolism_Homo sapiens_hsa012120.31481468
170Prostate cancer_Homo sapiens_hsa052150.30592059
171Pancreatic cancer_Homo sapiens_hsa052120.29419559
172Small cell lung cancer_Homo sapiens_hsa052220.24993841
173Arachidonic acid metabolism_Homo sapiens_hsa005900.24147219
174Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24053703

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »