ACTL6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.22404279
2DNA unwinding involved in DNA replication (GO:0006268)5.18531141
3DNA strand elongation (GO:0022616)4.98277674
4DNA replication initiation (GO:0006270)4.87561546
5telomere maintenance via semi-conservative replication (GO:0032201)4.82480107
6protein localization to kinetochore (GO:0034501)4.36131587
7nucleobase biosynthetic process (GO:0046112)4.32493641
8telomere maintenance via recombination (GO:0000722)4.28660277
9DNA replication checkpoint (GO:0000076)4.25414532
10ribosomal small subunit assembly (GO:0000028)4.11944726
11mitotic recombination (GO:0006312)4.11105939
12maturation of SSU-rRNA (GO:0030490)4.10126068
13CENP-A containing nucleosome assembly (GO:0034080)4.09118787
14chromatin remodeling at centromere (GO:0031055)4.07787939
15formation of translation preinitiation complex (GO:0001731)4.07483616
16DNA ligation (GO:0006266)4.06635277
17purine nucleobase biosynthetic process (GO:0009113)4.03184406
18DNA replication-dependent nucleosome organization (GO:0034723)4.00742268
19DNA replication-dependent nucleosome assembly (GO:0006335)4.00742268
20DNA deamination (GO:0045006)3.98679001
21mitotic metaphase plate congression (GO:0007080)3.94316634
22IMP biosynthetic process (GO:0006188)3.93489281
23telomere maintenance via telomere lengthening (GO:0010833)3.86871822
24establishment of viral latency (GO:0019043)3.85587390
25protein localization to chromosome, centromeric region (GO:0071459)3.85199646
26mitotic nuclear envelope disassembly (GO:0007077)3.78571973
27DNA replication-independent nucleosome assembly (GO:0006336)3.75960837
28DNA replication-independent nucleosome organization (GO:0034724)3.75960837
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.70508725
30kinetochore organization (GO:0051383)3.70135376
31negative regulation of ligase activity (GO:0051352)3.69291884
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.69291884
33mitotic spindle checkpoint (GO:0071174)3.64355325
34folic acid-containing compound biosynthetic process (GO:0009396)3.63479372
35establishment of integrated proviral latency (GO:0075713)3.58925888
36synapsis (GO:0007129)3.58825631
37mitotic spindle assembly checkpoint (GO:0007094)3.53197118
38IMP metabolic process (GO:0046040)3.50520887
39metaphase plate congression (GO:0051310)3.49791069
40non-recombinational repair (GO:0000726)3.48607147
41double-strand break repair via nonhomologous end joining (GO:0006303)3.48607147
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48484035
43nuclear pore organization (GO:0006999)3.47879570
44nuclear envelope disassembly (GO:0051081)3.47807686
45membrane disassembly (GO:0030397)3.47807686
46protein K6-linked ubiquitination (GO:0085020)3.47482690
47histone exchange (GO:0043486)3.45822698
48viral transcription (GO:0019083)3.45303512
49DNA double-strand break processing (GO:0000729)3.44428710
50mitotic chromosome condensation (GO:0007076)3.41327940
51translational termination (GO:0006415)3.40981855
52attachment of spindle microtubules to kinetochore (GO:0008608)3.40819310
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40067380
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40067380
55mitotic sister chromatid cohesion (GO:0007064)3.38969108
56ribosome assembly (GO:0042255)3.37328431
57ribosome biogenesis (GO:0042254)3.35957188
58regulation of sister chromatid segregation (GO:0033045)3.34894276
59regulation of mitotic sister chromatid separation (GO:0010965)3.34894276
60regulation of mitotic sister chromatid segregation (GO:0033047)3.34894276
61ribosomal small subunit biogenesis (GO:0042274)3.34246687
62DNA duplex unwinding (GO:0032508)3.33117980
63spliceosomal snRNP assembly (GO:0000387)3.32890914
64ribosomal large subunit biogenesis (GO:0042273)3.32663624
65ribonucleoprotein complex biogenesis (GO:0022613)3.31645924
66DNA catabolic process, exonucleolytic (GO:0000738)3.31615950
67DNA geometric change (GO:0032392)3.31585847
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29665098
69kinetochore assembly (GO:0051382)3.27280005
70mitotic sister chromatid segregation (GO:0000070)3.26760613
71DNA topological change (GO:0006265)3.25070186
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24419558
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24419558
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24419558
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22160301
76translational elongation (GO:0006414)3.21091868
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.21073247
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21073247
79establishment of chromosome localization (GO:0051303)3.20599384
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20048632
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.20026714
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.20026714
83cullin deneddylation (GO:0010388)3.19644436
84translational initiation (GO:0006413)3.18382487
85chromosome segregation (GO:0007059)3.18269422
86rRNA processing (GO:0006364)3.17558017
87signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17423726
88signal transduction involved in DNA damage checkpoint (GO:0072422)3.17423726
89regulation of centriole replication (GO:0046599)3.16217485
90signal transduction involved in cell cycle checkpoint (GO:0072395)3.15309617
91nuclear pore complex assembly (GO:0051292)3.14956295
92regulation of cellular amino acid metabolic process (GO:0006521)3.14865172
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14849218
94transcription-coupled nucleotide-excision repair (GO:0006283)3.14760313
95positive regulation of ligase activity (GO:0051351)3.13467443
96regulation of ubiquitin-protein transferase activity (GO:0051438)3.11182821
97regulation of DNA endoreduplication (GO:0032875)3.08909709
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08908091
99positive regulation of chromosome segregation (GO:0051984)3.08346679
100mismatch repair (GO:0006298)3.08110132
101rRNA metabolic process (GO:0016072)3.06749407
102meiotic chromosome segregation (GO:0045132)3.06337789
103regulation of spindle organization (GO:0090224)3.06098393
104regulation of nuclear cell cycle DNA replication (GO:0033262)3.03922489
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03286240
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02900739
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02456940
108protein deneddylation (GO:0000338)3.02424489
109sister chromatid segregation (GO:0000819)3.01457076
110telomere organization (GO:0032200)3.00381576
111G1/S transition of mitotic cell cycle (GO:0000082)3.00297790
112cell cycle G1/S phase transition (GO:0044843)3.00297790
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99931128
114chromatin assembly or disassembly (GO:0006333)2.99765695
115resolution of meiotic recombination intermediates (GO:0000712)2.99375914
116telomere maintenance (GO:0000723)2.99152937
117negative regulation of chromosome segregation (GO:0051985)2.98533910
118regulation of ligase activity (GO:0051340)2.98270903
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97443226
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.96319057
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96319057
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96319057
123negative regulation of sister chromatid segregation (GO:0033046)2.96319057
124proteasome assembly (GO:0043248)2.95233876
125pseudouridine synthesis (GO:0001522)2.94941550
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93042286
127base-excision repair (GO:0006284)2.90882703
128regulation of double-strand break repair via homologous recombination (GO:0010569)2.90712686
129spliceosomal complex assembly (GO:0000245)2.90575237
130RNA splicing, via transesterification reactions (GO:0000375)2.90364552
131regulation of chromosome segregation (GO:0051983)2.90075794
132cotranslational protein targeting to membrane (GO:0006613)2.89989660
133mRNA splicing, via spliceosome (GO:0000398)2.89701733
134RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89701733
135spindle checkpoint (GO:0031577)2.89669416
136viral mRNA export from host cell nucleus (GO:0046784)2.89554689
137spindle assembly checkpoint (GO:0071173)2.89206634
138DNA conformation change (GO:0071103)2.88936245
139negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87536955
140protein targeting to ER (GO:0045047)2.87330456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.93129044
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.26083946
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.04186514
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77608206
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62672172
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22402142
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18083360
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94942185
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.93724393
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83529632
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80457206
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.76266081
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69118493
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.64292023
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55749405
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50705319
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39190843
18XRN2_22483619_ChIP-Seq_HELA_Human2.34583707
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28482303
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28427058
21AR_21909140_ChIP-Seq_LNCAP_Human2.18536843
22VDR_23849224_ChIP-Seq_CD4+_Human2.16383250
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13253558
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05036973
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03096368
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00841711
27* E2F1_21310950_ChIP-Seq_MCF-7_Human1.95944248
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.95181319
29DCP1A_22483619_ChIP-Seq_HELA_Human1.90003808
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85437607
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84865561
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.84513675
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.81621291
34GABP_19822575_ChIP-Seq_HepG2_Human1.81452022
35TTF2_22483619_ChIP-Seq_HELA_Human1.79990525
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73539313
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72536263
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70974272
39* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70507134
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68151851
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67441509
42* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67135883
43CIITA_25753668_ChIP-Seq_RAJI_Human1.65806639
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62985213
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61292858
46ELK1_19687146_ChIP-ChIP_HELA_Human1.60512528
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57166783
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55483890
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54435920
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.53430943
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53342758
52MYC_22102868_ChIP-Seq_BL_Human1.53333881
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51028132
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47761149
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44432867
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38562645
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37141759
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.37125571
59KDM5A_27292631_Chip-Seq_BREAST_Human1.34522524
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28021983
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26868869
62* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26634506
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25652618
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25159921
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24496060
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22298914
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21843510
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16063272
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15933957
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15879305
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15709278
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14258964
73TFEB_21752829_ChIP-Seq_HELA_Human1.13061019
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10979012
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10832864
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10554667
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.09377184
78* TP63_19390658_ChIP-ChIP_HaCaT_Human1.08211290
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.03050350
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02800916
81EWS_26573619_Chip-Seq_HEK293_Human1.02278998
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01205548
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00099841
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99721254
85VDR_21846776_ChIP-Seq_THP-1_Human0.98334350
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.97919464
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.97713048
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97348148
89MYC_18940864_ChIP-ChIP_HL60_Human0.95900184
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93407760
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93197959
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91531636
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91086914
94* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90832374
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90593231
96* SPI1_23547873_ChIP-Seq_NB4_Human0.89271432
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87642763
98TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87229282
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.85617999
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83510961
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81945888
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79995843
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.79427070
104FUS_26573619_Chip-Seq_HEK293_Human0.79376368
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78883239
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78851624
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78576862
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78383870
109* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77285026
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76538001
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76262828
112ZNF274_21170338_ChIP-Seq_K562_Hela0.75601582
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73021864
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72080899
115IRF1_19129219_ChIP-ChIP_H3396_Human0.70785844
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66131900
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65284001
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.65059719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.19121362
2MP0010094_abnormal_chromosome_stability4.78778142
3MP0004957_abnormal_blastocyst_morpholog4.47554635
4MP0003111_abnormal_nucleus_morphology4.38910720
5MP0008057_abnormal_DNA_replication4.10599597
6MP0003077_abnormal_cell_cycle4.10169768
7MP0008058_abnormal_DNA_repair3.54214361
8MP0008007_abnormal_cellular_replicative3.07866452
9MP0008932_abnormal_embryonic_tissue2.64770737
10MP0009697_abnormal_copulation2.45783062
11MP0002396_abnormal_hematopoietic_system2.43868430
12MP0001730_embryonic_growth_arrest2.33967681
13MP0000350_abnormal_cell_proliferation2.27416084
14MP0003123_paternal_imprinting2.17681981
15MP0010352_gastrointestinal_tract_polyps2.09798577
16MP0008877_abnormal_DNA_methylation2.08943684
17MP0010030_abnormal_orbit_morphology1.98553873
18MP0010307_abnormal_tumor_latency1.74244801
19MP0003786_premature_aging1.73931476
20MP0000490_abnormal_crypts_of1.71798368
21MP0001697_abnormal_embryo_size1.71713763
22MP0005380_embryogenesis_phenotype1.68389022
23MP0001672_abnormal_embryogenesis/_devel1.68389022
24MP0002080_prenatal_lethality1.58368412
25MP0001293_anophthalmia1.58044806
26MP0003806_abnormal_nucleotide_metabolis1.57318380
27MP0002085_abnormal_embryonic_tissue1.55401159
28MP0003984_embryonic_growth_retardation1.50894384
29MP0000313_abnormal_cell_death1.49956749
30MP0002088_abnormal_embryonic_growth/wei1.46859771
31MP0002019_abnormal_tumor_incidence1.46332232
32MP0006035_abnormal_mitochondrial_morpho1.45984256
33MP0003763_abnormal_thymus_physiology1.41047614
34MP0004808_abnormal_hematopoietic_stem1.40542345
35MP0002084_abnormal_developmental_patter1.39314755
36MP0003718_maternal_effect1.38844433
37MP0008995_early_reproductive_senescence1.31934942
38MP0004197_abnormal_fetal_growth/weight/1.31819495
39MP0009333_abnormal_splenocyte_physiolog1.31491572
40MP0002086_abnormal_extraembryonic_tissu1.30749776
41MP0004147_increased_porphyrin_level1.30713856
42MP0003890_abnormal_embryonic-extraembry1.26882672
43MP0001529_abnormal_vocalization1.25579306
44MP0006072_abnormal_retinal_apoptosis1.25297333
45MP0000372_irregular_coat_pigmentation1.23767006
46MP0002210_abnormal_sex_determination1.21964554
47MP0005499_abnormal_olfactory_system1.19749448
48MP0005394_taste/olfaction_phenotype1.19749448
49MP0003121_genomic_imprinting1.16568567
50MP0000703_abnormal_thymus_morphology1.14620360
51MP0006292_abnormal_olfactory_placode1.12950272
52MP0003567_abnormal_fetal_cardiomyocyte1.12026209
53MP0001545_abnormal_hematopoietic_system1.11834346
54MP0005397_hematopoietic_system_phenotyp1.11834346
55MP0000647_abnormal_sebaceous_gland1.11802972
56MP0002398_abnormal_bone_marrow1.10507176
57MP0001145_abnormal_male_reproductive1.09552267
58MP0003315_abnormal_perineum_morphology1.06085752
59MP0006036_abnormal_mitochondrial_physio1.05049133
60MP0004133_heterotaxia1.03980078
61MP0002722_abnormal_immune_system1.03902194
62MP0003186_abnormal_redox_activity1.03682021
63MP0002233_abnormal_nose_morphology1.02507001
64MP0000689_abnormal_spleen_morphology1.01799498
65MP0001929_abnormal_gametogenesis1.00689924
66MP0006054_spinal_hemorrhage0.98961184
67MP0005076_abnormal_cell_differentiation0.96551681
68MP0002697_abnormal_eye_size0.96024324
69MP0002653_abnormal_ependyma_morphology0.95907745
70MP0001727_abnormal_embryo_implantation0.91777058
71MP0002234_abnormal_pharynx_morphology0.90541479
72MP0000653_abnormal_sex_gland0.90436684
73MP0002429_abnormal_blood_cell0.89177426
74MP0005408_hypopigmentation0.89099173
75MP0002938_white_spotting0.87020909
76MP0002160_abnormal_reproductive_system0.86732689
77MP0002111_abnormal_tail_morphology0.85642203
78MP0001853_heart_inflammation0.85464088
79MP0003941_abnormal_skin_development0.85034546
80MP0002751_abnormal_autonomic_nervous0.82058624
81MP0000537_abnormal_urethra_morphology0.81982678
82MP0003698_abnormal_male_reproductive0.81362070
83MP0009672_abnormal_birth_weight0.81306055
84MP0000358_abnormal_cell_content/0.80533456
85MP0005395_other_phenotype0.80442560
86MP0000858_altered_metastatic_potential0.79717496
87MP0003119_abnormal_digestive_system0.79041843
88MP0002092_abnormal_eye_morphology0.78939205
89MP0001119_abnormal_female_reproductive0.78053159
90MP0000427_abnormal_hair_cycle0.77355727
91MP0003755_abnormal_palate_morphology0.75623540
92MP0000716_abnormal_immune_system0.75000379
93MP0001764_abnormal_homeostasis0.74727160
94MP0002132_abnormal_respiratory_system0.74323953
95MP0001346_abnormal_lacrimal_gland0.73994801
96MP0009053_abnormal_anal_canal0.73672540
97MP0005384_cellular_phenotype0.73363262
98MP0005501_abnormal_skin_physiology0.72967167
99MP0008789_abnormal_olfactory_epithelium0.72914179
100MP0001915_intracranial_hemorrhage0.71033418
101MP0003937_abnormal_limbs/digits/tail_de0.70599617
102MP0010234_abnormal_vibrissa_follicle0.70178582
103MP0005389_reproductive_system_phenotype0.70092853
104MP0003943_abnormal_hepatobiliary_system0.69164554
105MP0002161_abnormal_fertility/fecundity0.69028480
106MP0003699_abnormal_female_reproductive0.68550806
107MP0000579_abnormal_nail_morphology0.66312078
108MP0005621_abnormal_cell_physiology0.66078225
109MP0000566_synostosis0.65726408
110MP0001286_abnormal_eye_development0.65339851
111MP0003950_abnormal_plasma_membrane0.65278386
112MP0005075_abnormal_melanosome_morpholog0.64889573
113MP0010678_abnormal_skin_adnexa0.64829194
114MP0005023_abnormal_wound_healing0.64674820
115MP0005391_vision/eye_phenotype0.63473528
116MP0005253_abnormal_eye_physiology0.63159605
117MP0009278_abnormal_bone_marrow0.62789154
118MP0001243_abnormal_dermal_layer0.62464270
119MP0000477_abnormal_intestine_morphology0.62040827
120MP0000762_abnormal_tongue_morphology0.61581103
121MP0001661_extended_life_span0.61455412
122MP0000383_abnormal_hair_follicle0.61440312
123MP0003861_abnormal_nervous_system0.60843087
124MP0000428_abnormal_craniofacial_morphol0.60408683
125MP0009703_decreased_birth_body0.60120657
126MP0002102_abnormal_ear_morphology0.59660384
127MP0002282_abnormal_trachea_morphology0.59283411
128MP0003221_abnormal_cardiomyocyte_apopto0.59177934
129MP0002075_abnormal_coat/hair_pigmentati0.57948104
130MP0000049_abnormal_middle_ear0.57262736
131MP0001835_abnormal_antigen_presentation0.56699633
132MP0005266_abnormal_metabolism0.56392737
133MP0000685_abnormal_immune_system0.55397591
134MP0002420_abnormal_adaptive_immunity0.53471262
135MP0001800_abnormal_humoral_immune0.53362487
136MP0002095_abnormal_skin_pigmentation0.52255822
137MP0001819_abnormal_immune_cell0.51977755
138MP0002405_respiratory_system_inflammati0.50822220
139MP0009379_abnormal_foot_pigmentation0.50187163

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.06178145
2Reticulocytopenia (HP:0001896)4.44245983
3Chromsome breakage (HP:0040012)3.82645796
4Abnormality of cells of the erythroid lineage (HP:0012130)3.79952621
5Colon cancer (HP:0003003)3.78769004
6Breast hypoplasia (HP:0003187)3.74276494
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64898182
8Abnormal number of erythroid precursors (HP:0012131)3.61969533
9Oral leukoplakia (HP:0002745)3.52054697
10Selective tooth agenesis (HP:0001592)3.41703127
11Abnormality of the anterior horn cell (HP:0006802)3.28752185
12Degeneration of anterior horn cells (HP:0002398)3.28752185
13Patellar aplasia (HP:0006443)3.25946167
14Aplastic anemia (HP:0001915)3.23303353
15Medulloblastoma (HP:0002885)3.20146633
16Increased serum pyruvate (HP:0003542)3.14674279
17Aplasia/Hypoplasia of the patella (HP:0006498)3.04804007
18Abnormality of glycolysis (HP:0004366)3.02968534
19Acute necrotizing encephalopathy (HP:0006965)2.98006797
20Abnormality of chromosome stability (HP:0003220)2.95996279
21Ependymoma (HP:0002888)2.94502687
22Acute encephalopathy (HP:0006846)2.94453608
23Meckel diverticulum (HP:0002245)2.88867447
2411 pairs of ribs (HP:0000878)2.86396623
25Abnormality of the preputium (HP:0100587)2.84857934
26Carpal bone hypoplasia (HP:0001498)2.83858579
27Rough bone trabeculation (HP:0100670)2.81390150
28Volvulus (HP:0002580)2.81389287
29Abnormality of the ileum (HP:0001549)2.78572199
30Agnosia (HP:0010524)2.76214182
31Cerebral hypomyelination (HP:0006808)2.75487603
32Abnormal mitochondria in muscle tissue (HP:0008316)2.75483970
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.75347401
34Increased CSF lactate (HP:0002490)2.73761218
35Increased hepatocellular lipid droplets (HP:0006565)2.69423489
36Absent thumb (HP:0009777)2.65008313
37Pallor (HP:0000980)2.64582037
38Myelodysplasia (HP:0002863)2.63358588
39Macrocytic anemia (HP:0001972)2.63200710
40Abnormal number of incisors (HP:0011064)2.62785735
41Absent radius (HP:0003974)2.62247884
42Mitochondrial inheritance (HP:0001427)2.59890616
43Hepatocellular necrosis (HP:0001404)2.57993642
44Premature graying of hair (HP:0002216)2.57849555
45Hypoplastic pelvis (HP:0008839)2.56714233
46Small intestinal stenosis (HP:0012848)2.53854527
47Duodenal stenosis (HP:0100867)2.53854527
48Abnormal lung lobation (HP:0002101)2.53047732
49Impulsivity (HP:0100710)2.52811572
50Microretrognathia (HP:0000308)2.47357115
51Neoplasm of the pancreas (HP:0002894)2.46190490
52Bone marrow hypocellularity (HP:0005528)2.44725037
53Rhabdomyosarcoma (HP:0002859)2.43695437
54Aplasia involving forearm bones (HP:0009822)2.42936273
55Absent forearm bone (HP:0003953)2.42936273
56Microvesicular hepatic steatosis (HP:0001414)2.41976058
57Lipid accumulation in hepatocytes (HP:0006561)2.41261664
58Cortical dysplasia (HP:0002539)2.40750372
59Abnormality of methionine metabolism (HP:0010901)2.40501212
60Embryonal renal neoplasm (HP:0011794)2.38819778
61Ectopic kidney (HP:0000086)2.35724198
62Increased serum lactate (HP:0002151)2.33494597
63Multiple enchondromatosis (HP:0005701)2.33407377
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33057745
65Progressive macrocephaly (HP:0004481)2.32928096
66Sloping forehead (HP:0000340)2.30811192
67Cerebral edema (HP:0002181)2.29864996
68Hepatic necrosis (HP:0002605)2.29559093
69Missing ribs (HP:0000921)2.29369918
70Cellular immunodeficiency (HP:0005374)2.28626386
71Atresia of the external auditory canal (HP:0000413)2.28113943
72Duplicated collecting system (HP:0000081)2.26874301
73Trismus (HP:0000211)2.24809921
74Supernumerary spleens (HP:0009799)2.23310062
75Tracheoesophageal fistula (HP:0002575)2.22473035
76Proximal placement of thumb (HP:0009623)2.22199449
77Type I transferrin isoform profile (HP:0003642)2.21499456
78Increased nuchal translucency (HP:0010880)2.19248662
79Abnormality of the duodenum (HP:0002246)2.16895921
80Horseshoe kidney (HP:0000085)2.15784694
81Abnormality of the renal collecting system (HP:0004742)2.15352285
82Cleft eyelid (HP:0000625)2.11918305
83Reduced antithrombin III activity (HP:0001976)2.11886217
84Lymphoma (HP:0002665)2.08852012
85Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08102848
86Deviation of the thumb (HP:0009603)2.08052996
87Glioma (HP:0009733)2.06368662
88Basal cell carcinoma (HP:0002671)2.05598520
89Facial cleft (HP:0002006)2.04462938
90Abnormal trabecular bone morphology (HP:0100671)2.03842237
91Postnatal microcephaly (HP:0005484)2.02342317
92Triphalangeal thumb (HP:0001199)1.99662132
93Pancytopenia (HP:0001876)1.99226830
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98792601
95Premature ovarian failure (HP:0008209)1.98677257
96Hyperglycinemia (HP:0002154)1.98077351
97Abnormality of serum amino acid levels (HP:0003112)1.97349886
98Abnormality of pyrimidine metabolism (HP:0004353)1.96537128
99Lactic acidosis (HP:0003128)1.95649226
100Short thumb (HP:0009778)1.94764376
101Thrombocytosis (HP:0001894)1.94498573
102Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93194554
103Abnormality of the carotid arteries (HP:0005344)1.92180951
104Abnormality of the labia minora (HP:0012880)1.91635897
105Aplasia/Hypoplasia of the sternum (HP:0006714)1.91510430
106Glossoptosis (HP:0000162)1.87146862
107Atrophy/Degeneration involving motor neurons (HP:0007373)1.86605243
108Slender long bone (HP:0003100)1.86603405
109Optic nerve coloboma (HP:0000588)1.85640372
110Clubbing of toes (HP:0100760)1.85594755
111Squamous cell carcinoma (HP:0002860)1.84979744
112Sparse eyelashes (HP:0000653)1.84015055
113Amaurosis fugax (HP:0100576)1.83485390
114Neoplasm of the colon (HP:0100273)1.82708358
115Neoplasm of the oral cavity (HP:0100649)1.82249808
116Megaloblastic anemia (HP:0001889)1.81977415
117IgM deficiency (HP:0002850)1.81847070
118Shoulder girdle muscle weakness (HP:0003547)1.81655506
119Gonadotropin excess (HP:0000837)1.78116092
120Hypoplasia of the radius (HP:0002984)1.77896823
121Nephroblastoma (Wilms tumor) (HP:0002667)1.77704972
122Neoplasm of striated muscle (HP:0009728)1.77443954
123Secondary amenorrhea (HP:0000869)1.76910200
124Neoplasm of the adrenal gland (HP:0100631)1.75645054
125Choanal atresia (HP:0000453)1.75412649
126High pitched voice (HP:0001620)1.74928702
127Abnormal glycosylation (HP:0012345)1.73983084
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73983084
129Abnormal protein N-linked glycosylation (HP:0012347)1.73983084
130Abnormal protein glycosylation (HP:0012346)1.73983084
131Microglossia (HP:0000171)1.73885172
132Abnormality of DNA repair (HP:0003254)1.73751905
133Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73739718
134Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73739718
135Stenosis of the external auditory canal (HP:0000402)1.73529871
136Abnormality of the astrocytes (HP:0100707)1.73090433
137Astrocytoma (HP:0009592)1.73090433
138Abnormality of reticulocytes (HP:0004312)1.72995787
139Respiratory failure (HP:0002878)1.72752276
140Facial hemangioma (HP:0000329)1.72567050
141Asplenia (HP:0001746)1.72501184
142Renal Fanconi syndrome (HP:0001994)1.70873880
143Preaxial hand polydactyly (HP:0001177)1.70375694
144Ovarian neoplasm (HP:0100615)1.69694690
145Median cleft lip (HP:0000161)1.69047075
146Breast carcinoma (HP:0003002)1.67837145
147Methylmalonic acidemia (HP:0002912)1.67349961
148Bifid tongue (HP:0010297)1.66353412
149Cafe-au-lait spot (HP:0000957)1.64544767
150Small hand (HP:0200055)1.64470563
151Abnormality of glycine metabolism (HP:0010895)1.62523267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.83827732
2CDC74.33899715
3WEE14.29966361
4VRK23.15862506
5EIF2AK13.09920791
6NEK22.74752067
7TRIM282.53854830
8SRPK12.39669000
9BRSK22.33191267
10TTK2.21140905
11ACVR1B2.17699982
12TSSK62.11211299
13TESK22.10988596
14STK162.09413058
15PASK2.06314365
16PLK42.00537534
17VRK12.00098489
18PLK11.95718364
19EIF2AK31.91851067
20NEK11.86422276
21ATR1.83399746
22CDK71.81504254
23MKNK11.76288666
24NUAK11.74172888
25RPS6KB21.72522305
26NME21.71363143
27DYRK31.68461970
28AURKB1.68416641
29TAF11.61666982
30RPS6KA41.58564866
31CCNB11.57713001
32PLK31.50844560
33TGFBR11.47910301
34BCR1.45834744
35BRSK11.42652286
36EEF2K1.41507624
37TLK11.35874063
38STK101.34614797
39CHEK21.33356340
40CDK41.32915060
41CDK121.31857048
42SCYL21.31083524
43AURKA1.29078812
44BMPR1B1.26451462
45MAP3K81.25101498
46CHEK11.20554782
47STK41.18792782
48FLT31.18596326
49PNCK1.15437436
50PAK41.15358712
51NME11.10718497
52MKNK21.05975715
53MAP4K21.01460672
54KDR1.01001426
55PBK1.00954767
56EPHA20.96269050
57MAP4K10.95980260
58MAP3K100.93283074
59TESK10.93126646
60ZAK0.91514003
61MET0.91336599
62WNK30.90747113
63ATM0.85567903
64PIM10.84931604
65CSNK1G10.82510284
66PDK20.81156015
67CDK20.78811775
68BRD40.78441375
69PIM20.78169584
70PLK20.76677868
71CSNK1G30.75840509
72MST1R0.75058365
73ERBB30.73552146
74MELK0.72008987
75CDK80.71956404
76STK38L0.71780971
77CSNK2A20.70207942
78EIF2AK20.69898592
79CLK10.69803457
80CSNK2A10.68723211
81MAPKAPK30.67910977
82MAP3K120.67802379
83LRRK20.64286485
84PAK10.62312525
85SIK30.62261629
86CDK10.61009204
87CDK60.59874666
88ERBB40.59570794
89MST40.59527321
90BTK0.57434372
91RPS6KA50.56627028
92CSNK1G20.53760788
93CSNK1A1L0.53468112
94BCKDK0.53200469
95CDK90.51174366
96CDK190.50842479
97DAPK10.44701345
98YES10.44700525
99CSF1R0.44526316
100MINK10.43092544
101BRAF0.42992763
102MAP3K110.42465500
103PRKCI0.41889080
104KIT0.41200395
105ZAP700.41013231
106LIMK10.41006686
107DYRK20.40796825
108TEC0.39800409
109MAP2K30.39687943
110CSNK1E0.37035659
111PKN20.36505122
112ALK0.35603163
113CDK180.34268601
114PDK30.34081307
115PDK40.34081307
116SMG10.32454931
117MARK30.31707211
118AKT20.31494647
119MAP2K70.31393825
120CDK140.30971177
121PRKDC0.28638873
122RAF10.27920656
123JAK30.27722466
124CDK11A0.26963279
125CDK30.26584611
126MTOR0.26158733
127CDK150.25829359
128IRAK40.25723366
129STK30.25460173
130TYK20.24141168
131ILK0.23996179
132LYN0.22599519
133GRK60.22424367
134MAPKAPK20.22283894
135NLK0.20535886
136PAK20.20003569
137FGFR10.19475780

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29533832
2Mismatch repair_Homo sapiens_hsa034304.45779404
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38205825
4Spliceosome_Homo sapiens_hsa030403.35180985
5Base excision repair_Homo sapiens_hsa034103.31212656
6Proteasome_Homo sapiens_hsa030503.28332635
7Ribosome_Homo sapiens_hsa030103.21448373
8Homologous recombination_Homo sapiens_hsa034403.14838798
9RNA polymerase_Homo sapiens_hsa030203.05405127
10RNA transport_Homo sapiens_hsa030132.96488411
11Nucleotide excision repair_Homo sapiens_hsa034202.90452963
12Cell cycle_Homo sapiens_hsa041102.70230324
13One carbon pool by folate_Homo sapiens_hsa006702.57923361
14Pyrimidine metabolism_Homo sapiens_hsa002402.50295616
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42506638
16Non-homologous end-joining_Homo sapiens_hsa034502.34717560
17Fanconi anemia pathway_Homo sapiens_hsa034602.18454342
18RNA degradation_Homo sapiens_hsa030181.96006539
19Basal transcription factors_Homo sapiens_hsa030221.84127319
20mRNA surveillance pathway_Homo sapiens_hsa030151.66030550
21Oxidative phosphorylation_Homo sapiens_hsa001901.64732850
22Propanoate metabolism_Homo sapiens_hsa006401.54847486
23p53 signaling pathway_Homo sapiens_hsa041151.54064672
24Fatty acid elongation_Homo sapiens_hsa000621.50863557
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47142377
26Pyruvate metabolism_Homo sapiens_hsa006201.45225406
27Purine metabolism_Homo sapiens_hsa002301.32155885
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32001627
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26596122
30Steroid biosynthesis_Homo sapiens_hsa001001.25596324
31Systemic lupus erythematosus_Homo sapiens_hsa053221.24730444
32Epstein-Barr virus infection_Homo sapiens_hsa051691.19322330
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10879519
34Herpes simplex infection_Homo sapiens_hsa051681.01656297
35Antigen processing and presentation_Homo sapiens_hsa046121.01032634
36Protein export_Homo sapiens_hsa030600.94567502
37Viral carcinogenesis_Homo sapiens_hsa052030.92716980
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.89177681
39Pentose phosphate pathway_Homo sapiens_hsa000300.87510552
40Biosynthesis of amino acids_Homo sapiens_hsa012300.86087553
41Selenocompound metabolism_Homo sapiens_hsa004500.83973369
42Alzheimers disease_Homo sapiens_hsa050100.83385226
43Folate biosynthesis_Homo sapiens_hsa007900.82387865
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81548751
45Oocyte meiosis_Homo sapiens_hsa041140.79621271
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.76935737
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.73485997
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73361215
49Primary immunodeficiency_Homo sapiens_hsa053400.71977521
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71370046
51Legionellosis_Homo sapiens_hsa051340.71274610
52HTLV-I infection_Homo sapiens_hsa051660.70613313
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68995270
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65646699
55Glutathione metabolism_Homo sapiens_hsa004800.61994974
56Caffeine metabolism_Homo sapiens_hsa002320.57875773
57Fatty acid metabolism_Homo sapiens_hsa012120.57294309
58Sulfur relay system_Homo sapiens_hsa041220.56848390
59Thyroid cancer_Homo sapiens_hsa052160.56211061
60Small cell lung cancer_Homo sapiens_hsa052220.55574906
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55311953
62MicroRNAs in cancer_Homo sapiens_hsa052060.54407920
63Butanoate metabolism_Homo sapiens_hsa006500.49745697
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49395048
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48381202
66Carbon metabolism_Homo sapiens_hsa012000.48301725
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48187079
68N-Glycan biosynthesis_Homo sapiens_hsa005100.46408973
69Measles_Homo sapiens_hsa051620.46030362
70Lysine degradation_Homo sapiens_hsa003100.45874876
71Vitamin B6 metabolism_Homo sapiens_hsa007500.45699208
72Apoptosis_Homo sapiens_hsa042100.45274372
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43780508
74Sulfur metabolism_Homo sapiens_hsa009200.41709943
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40524737
76Basal cell carcinoma_Homo sapiens_hsa052170.40232218
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40099692
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.39907627
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39668954
80Peroxisome_Homo sapiens_hsa041460.38413727
81Huntingtons disease_Homo sapiens_hsa050160.38259445
82Alcoholism_Homo sapiens_hsa050340.38230623
83Shigellosis_Homo sapiens_hsa051310.37239742
84Notch signaling pathway_Homo sapiens_hsa043300.35588674
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35177738
86TGF-beta signaling pathway_Homo sapiens_hsa043500.34877508
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34818891
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32947230
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32601836
90Hippo signaling pathway_Homo sapiens_hsa043900.32551908
91Hepatitis B_Homo sapiens_hsa051610.30949679
92Arginine and proline metabolism_Homo sapiens_hsa003300.29456804
93Colorectal cancer_Homo sapiens_hsa052100.29309021
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28092779
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27267556
96beta-Alanine metabolism_Homo sapiens_hsa004100.26811614
97Fatty acid degradation_Homo sapiens_hsa000710.26449229
98Viral myocarditis_Homo sapiens_hsa054160.26200318
99Hematopoietic cell lineage_Homo sapiens_hsa046400.24447017
100Influenza A_Homo sapiens_hsa051640.24432164
101Fructose and mannose metabolism_Homo sapiens_hsa000510.23431062
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22589296
103Galactose metabolism_Homo sapiens_hsa000520.22023641
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21991993
105Bladder cancer_Homo sapiens_hsa052190.21437426
106Metabolic pathways_Homo sapiens_hsa011000.21339094
107Pathways in cancer_Homo sapiens_hsa052000.19605812
108Parkinsons disease_Homo sapiens_hsa050120.19482132
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19246269
110Vitamin digestion and absorption_Homo sapiens_hsa049770.18881263
111Hedgehog signaling pathway_Homo sapiens_hsa043400.17853098
112Chronic myeloid leukemia_Homo sapiens_hsa052200.16423992
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.15342129
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15320211
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.15280816
116Tryptophan metabolism_Homo sapiens_hsa003800.14137929
117HIF-1 signaling pathway_Homo sapiens_hsa040660.13268012
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12087581
119Wnt signaling pathway_Homo sapiens_hsa043100.12002211
120Adherens junction_Homo sapiens_hsa045200.11706466
121Asthma_Homo sapiens_hsa053100.10443665
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10295362
123Arachidonic acid metabolism_Homo sapiens_hsa005900.09450689
124Acute myeloid leukemia_Homo sapiens_hsa052210.07818790
125Tyrosine metabolism_Homo sapiens_hsa003500.07040446
126Renin-angiotensin system_Homo sapiens_hsa046140.06687229
127Allograft rejection_Homo sapiens_hsa053300.06676332
128Cardiac muscle contraction_Homo sapiens_hsa042600.05195452
129Regulation of autophagy_Homo sapiens_hsa041400.04861557
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.02868308

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