ACTL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.91046487
2epithelial cilium movement (GO:0003351)9.90923564
3plasma membrane fusion (GO:0045026)9.81915819
4axonemal dynein complex assembly (GO:0070286)9.73170657
5motile cilium assembly (GO:0044458)9.49984507
6reproduction (GO:0000003)9.32877473
7cilium or flagellum-dependent cell motility (GO:0001539)8.79687754
8regulation of cilium movement (GO:0003352)8.49630251
9cilium movement (GO:0003341)8.01086275
10negative regulation of inclusion body assembly (GO:0090084)7.52728717
11sperm capacitation (GO:0048240)7.44997577
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.36036148
13single fertilization (GO:0007338)7.21589693
14synaptonemal complex organization (GO:0070193)7.19299308
15synaptonemal complex assembly (GO:0007130)7.10834962
16male meiosis (GO:0007140)6.98413240
17piRNA metabolic process (GO:0034587)6.92644420
18spermatogenesis (GO:0007283)6.81665300
19male gamete generation (GO:0048232)6.79154022
20organic cation transport (GO:0015695)6.76868953
21microtubule depolymerization (GO:0007019)6.59671054
22regulation of inclusion body assembly (GO:0090083)6.24193942
23gamete generation (GO:0007276)6.24026556
24fertilization (GO:0009566)6.14911716
25calcium ion-dependent exocytosis (GO:0017156)5.73559293
26spermatid nucleus differentiation (GO:0007289)5.67749567
27chromosome condensation (GO:0030261)5.54413448
28germ cell development (GO:0007281)5.47875164
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.37853925
30DNA packaging (GO:0006323)5.24085402
31glycerol ether metabolic process (GO:0006662)5.06003911
32cell recognition (GO:0008037)5.05345930
33ventricular system development (GO:0021591)5.04833186
34regulation of microtubule-based movement (GO:0060632)5.01394519
35sexual reproduction (GO:0019953)4.91216902
36microtubule severing (GO:0051013)4.91176027
37multicellular organismal reproductive process (GO:0048609)4.90810691
38chromosome organization involved in meiosis (GO:0070192)4.80704018
39ether metabolic process (GO:0018904)4.67634170
40male meiosis I (GO:0007141)4.66001966
41seminiferous tubule development (GO:0072520)4.59959844
42single strand break repair (GO:0000012)4.57780106
43DNA methylation involved in gamete generation (GO:0043046)4.41724045
44left/right pattern formation (GO:0060972)4.27725124
45meiotic nuclear division (GO:0007126)4.20255104
46chaperone-mediated protein complex assembly (GO:0051131)4.18994641
47multicellular organismal development (GO:0007275)3.95655955
48meiosis I (GO:0007127)3.70846878
49protein K11-linked deubiquitination (GO:0035871)3.69174078
50protein polyglutamylation (GO:0018095)3.57986535
51sequestering of actin monomers (GO:0042989)3.55237546
52genitalia morphogenesis (GO:0035112)3.50357327
53microtubule polymerization or depolymerization (GO:0031109)3.38453731
54meiotic cell cycle (GO:0051321)3.36927357
55protein refolding (GO:0042026)3.32887391
56regulation of spindle checkpoint (GO:0090231)3.31548004
57glycolytic process (GO:0006096)3.20511069
58amino-acid betaine transport (GO:0015838)3.16848474
59carnitine transport (GO:0015879)3.16848474
60nucleus organization (GO:0006997)3.15315280
61monoubiquitinated protein deubiquitination (GO:0035520)3.14383512
62positive regulation of macrophage activation (GO:0043032)3.09719385
63protein localization to cilium (GO:0061512)3.08944660
64carnitine transmembrane transport (GO:1902603)2.99490167
65mitotic sister chromatid cohesion (GO:0007064)2.97624046
66polyol catabolic process (GO:0046174)2.96003592
67interferon-gamma secretion (GO:0072643)2.94946824
68nucleoside diphosphate phosphorylation (GO:0006165)2.93405463
69alditol metabolic process (GO:0019400)2.91921156
70polyamine biosynthetic process (GO:0006596)2.91729741
71chromatin silencing (GO:0006342)2.85020336
72RNA localization (GO:0006403)2.79713628
73cilium organization (GO:0044782)2.76466764
74meiotic cell cycle process (GO:1903046)2.75157387
75microtubule-based movement (GO:0007018)2.71449159
76synapsis (GO:0007129)2.69994791
77regulation of cilium assembly (GO:1902017)2.68864799
78RNA destabilization (GO:0050779)2.67196846
79cilium assembly (GO:0042384)2.65872711
80cellular component assembly involved in morphogenesis (GO:0010927)2.64047815
81GTP biosynthetic process (GO:0006183)2.63416380
82cilium morphogenesis (GO:0060271)2.61864431
83intraciliary transport (GO:0042073)2.57706272
84axoneme assembly (GO:0035082)2.54391430
85mitochondrion degradation (GO:0000422)2.50785070
86peptidyl-glutamic acid modification (GO:0018200)2.50426745
87negative regulation of organelle assembly (GO:1902116)2.50263542
88protein-DNA complex disassembly (GO:0032986)2.45358818
89nucleosome disassembly (GO:0006337)2.45358818
90glycerol metabolic process (GO:0006071)2.44179752
91sperm motility (GO:0030317)14.2614102
92cell wall macromolecule catabolic process (GO:0016998)13.6373446
93cell wall macromolecule metabolic process (GO:0044036)13.6373446
94fusion of sperm to egg plasma membrane (GO:0007342)12.8907298
95acrosome reaction (GO:0007340)12.4510326
96acrosome assembly (GO:0001675)11.6361523
97sperm-egg recognition (GO:0035036)11.6346145
98binding of sperm to zona pellucida (GO:0007339)10.6544436
99multicellular organism reproduction (GO:0032504)10.5906620
100cell-cell recognition (GO:0009988)10.4213886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.34118496
2EZH2_22144423_ChIP-Seq_EOC_Human4.16889231
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.92786809
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.18222479
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.97050537
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84686068
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.72972465
8VDR_22108803_ChIP-Seq_LS180_Human2.51602419
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28315287
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.26554248
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16799871
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07404733
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.92946189
14KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.83856520
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81648826
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81587066
17FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77492314
18STAT1_17558387_ChIP-Seq_HELA_Human1.72736891
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70368441
20MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69821406
21SOX2_22085726_ChIP-Seq_NPCs_Mouse1.68796431
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63703375
23GATA3_21867929_ChIP-Seq_CD8_Mouse1.63586225
24GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.55953593
25WDR5_24793694_ChIP-Seq_LNCAP_Human1.49065894
26KDM2B_26808549_Chip-Seq_REH_Human1.47293489
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46221818
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46095945
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.42979400
30PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42529208
31KAP1_22055183_ChIP-Seq_ESCs_Mouse1.41141604
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39265518
33CBP_20019798_ChIP-Seq_JUKART_Human1.39265518
34* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38277341
35P53_21459846_ChIP-Seq_SAOS-2_Human1.37575984
36LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37276115
37REST_21632747_ChIP-Seq_MESCs_Mouse1.36264442
38SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34347642
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.31828183
40GATA3_21867929_ChIP-Seq_TH1_Mouse1.29460859
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28935444
42RAD21_21589869_ChIP-Seq_MESCs_Mouse1.25438658
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23832417
44* ZNF274_21170338_ChIP-Seq_K562_Hela1.23549536
45FLI1_21867929_ChIP-Seq_TH2_Mouse1.23364154
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22835108
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.21401719
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20361610
49SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19544092
50CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19354053
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18624100
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17368469
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17368469
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14937728
55* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13898405
56RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13500636
57* GF1_26923725_Chip-Seq_HPCs_Mouse1.13493218
58SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11613864
59RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10915885
60* SPI1_26923725_Chip-Seq_HPCs_Mouse1.10009970
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09831431
62GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09229300
63MYC_27129775_Chip-Seq_CORNEA_Mouse1.09115439
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08803003
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.07888453
66ESET_19884257_ChIP-Seq_ESCs_Mouse1.07408010
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06885686
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.06878334
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06788124
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.06497134
71ERG_20517297_ChIP-Seq_VCAP_Human1.05958737
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05935795
73RARA_24833708_ChIP-Seq_LIVER_Mouse1.05861412
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03924847
75* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03593839
76JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02835506
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02136570
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.01746230
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00112170
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98679590
81LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98018825
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97521152
83OCT4_18555785_Chip-Seq_ESCs_Mouse0.97154278
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96203484
85FLI1_21867929_ChIP-Seq_CD8_Mouse0.95227801
86CTCF_20526341_ChIP-Seq_ESCs_Human0.95054389
87SOX11_22085726_ChIP-Seq_ESNs_Mouse0.94072474
88P53_22387025_ChIP-Seq_ESCs_Mouse0.93042777
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92711564
90NFYB_21822215_ChIP-Seq_K562_Human0.91083608
91CMYC_18555785_Chip-Seq_ESCs_Mouse0.90689726
92BCOR_27268052_Chip-Seq_Bcells_Human0.90560597
93TAF15_26573619_Chip-Seq_HEK293_Human0.89707312
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89671333
95NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89410257
96OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88875876
97* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88521819
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88414497
99SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87394425
100NANOG_20526341_ChIP-Seq_ESCs_Human0.87227648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.10000669
2MP0001929_abnormal_gametogenesis5.58141534
3MP0008877_abnormal_DNA_methylation3.84081012
4MP0002210_abnormal_sex_determination3.34762519
5MP0002161_abnormal_fertility/fecundity3.32621455
6MP0005670_abnormal_white_adipose3.02674903
7MP0001145_abnormal_male_reproductive2.85874392
8MP0000653_abnormal_sex_gland2.46582699
9MP0002653_abnormal_ependyma_morphology2.31533229
10MP0005410_abnormal_fertilization16.6503865
11MP0004233_abnormal_muscle_weight1.52379012
12MP0003646_muscle_fatigue1.45708758
13MP0002160_abnormal_reproductive_system1.45277597
14MP0005623_abnormal_meninges_morphology1.37996957
15MP0002282_abnormal_trachea_morphology1.11522764
16MP0001765_abnormal_ion_homeostasis1.09841549
17MP0002234_abnormal_pharynx_morphology1.05245350
18MP0001984_abnormal_olfaction1.03795472
19MP0009046_muscle_twitch0.88750709
20MP0008058_abnormal_DNA_repair0.88561810
21MP0005647_abnormal_sex_gland0.80701722
22MP0005389_reproductive_system_phenotype0.68988250
23MP0003011_delayed_dark_adaptation0.68442425
24MP0003115_abnormal_respiratory_system0.67883184
25MP0008995_early_reproductive_senescence0.63596826
26MP0005636_abnormal_mineral_homeostasis0.63053561
27MP0005666_abnormal_adipose_tissue0.59823477
28MP0003329_amyloid_beta_deposits0.58677645
29MP0005377_hearing/vestibular/ear_phenot0.54901899
30MP0003878_abnormal_ear_physiology0.54901899
31MP0004036_abnormal_muscle_relaxation0.53578386
32MP0002736_abnormal_nociception_after0.52914714
33MP0002269_muscular_atrophy0.52760780
34MP0001764_abnormal_homeostasis0.52240100
35MP0000358_abnormal_cell_content/0.52005701
36MP0001324_abnormal_eye_pigmentation0.51544947
37MP0001293_anophthalmia0.46349394
38MP0010094_abnormal_chromosome_stability0.45586139
39MP0003699_abnormal_female_reproductive0.44520100
40MP0006036_abnormal_mitochondrial_physio0.43587012
41MP0000569_abnormal_digit_pigmentation0.38885767
42MP0009115_abnormal_fat_cell0.38828696
43MP0005551_abnormal_eye_electrophysiolog0.38787328
44MP0005253_abnormal_eye_physiology0.38355253
45MP0002928_abnormal_bile_duct0.38105896
46MP0000534_abnormal_ureter_morphology0.37638526
47MP0001545_abnormal_hematopoietic_system0.36228974
48MP0005397_hematopoietic_system_phenotyp0.36228974
49MP0003950_abnormal_plasma_membrane0.35997569
50MP0004133_heterotaxia0.35353584
51MP0009278_abnormal_bone_marrow0.35094490
52MP0002971_abnormal_brown_adipose0.34119251
53MP0002139_abnormal_hepatobiliary_system0.32110649
54MP0004811_abnormal_neuron_physiology0.30930063
55MP0000604_amyloidosis0.30279352
56MP0003633_abnormal_nervous_system0.29653579
57MP0001968_abnormal_touch/_nociception0.29536044
58MP0005391_vision/eye_phenotype0.29401555
59MP0002102_abnormal_ear_morphology0.27263990
60MP0003111_abnormal_nucleus_morphology0.26686223
61MP0003942_abnormal_urinary_system0.25528704
62MP0004019_abnormal_vitamin_homeostasis0.25425408
63MP0006035_abnormal_mitochondrial_morpho0.25393964
64MP0001730_embryonic_growth_arrest0.25212060
65MP0003631_nervous_system_phenotype0.24860874
66MP0003861_abnormal_nervous_system0.24771388
67MP0001119_abnormal_female_reproductive0.24477744
68MP0002152_abnormal_brain_morphology0.23281216
69MP0002169_no_abnormal_phenotype0.23273874
70MP0002873_normal_phenotype0.23042707
71MP0003948_abnormal_gas_homeostasis0.22140336
72MP0003879_abnormal_hair_cell0.21579730
73MP0004043_abnormal_pH_regulation0.20490326
74MP0008875_abnormal_xenobiotic_pharmacok0.19546565
75MP0004145_abnormal_muscle_electrophysio0.19299451
76MP0001849_ear_inflammation0.18137694
77MP0004742_abnormal_vestibular_system0.17827007
78MP0010307_abnormal_tumor_latency0.17740198
79MP0005375_adipose_tissue_phenotype0.17528236
80MP0002295_abnormal_pulmonary_circulatio0.16129314
81MP0005365_abnormal_bile_salt0.15834138
82MP0008569_lethality_at_weaning0.15659907
83MP0004130_abnormal_muscle_cell0.15560316
84MP0002092_abnormal_eye_morphology0.15528787
85MP0003959_abnormal_lean_body0.15497391
86MP0004270_analgesia0.15366579
87MP0002229_neurodegeneration0.15001327
88MP0005319_abnormal_enzyme/_coenzyme0.14633664
89MP0008961_abnormal_basal_metabolism0.14611447
90MP0000001_mammalian_phenotype0.14377878
91MP0003786_premature_aging0.14072922
92MP0002118_abnormal_lipid_homeostasis0.14001906
93MP0000462_abnormal_digestive_system0.13410886
94MP0000313_abnormal_cell_death0.13203653
95MP0001661_extended_life_span0.13135373
96MP0000751_myopathy0.13051120
97MP0002084_abnormal_developmental_patter0.12773888
98MP0002693_abnormal_pancreas_physiology0.12290742
99MP0001727_abnormal_embryo_implantation0.11977225
100MP0005195_abnormal_posterior_eye0.11949866

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.37913319
2Abnormal respiratory epithelium morphology (HP:0012253)9.27718753
3Abnormal respiratory motile cilium morphology (HP:0005938)9.27718753
4Rhinitis (HP:0012384)7.53713070
5Chronic bronchitis (HP:0004469)7.46066309
6Abnormal ciliary motility (HP:0012262)7.32673141
7Infertility (HP:0000789)6.99657496
8Nasal polyposis (HP:0100582)6.48880170
9Abnormality of the nasal mucosa (HP:0000433)5.33558832
10Male infertility (HP:0003251)4.69666275
11Bronchitis (HP:0012387)4.61050307
12Bronchiectasis (HP:0002110)4.43042948
13Nephronophthisis (HP:0000090)4.07922062
14Abnormal spermatogenesis (HP:0008669)3.56644744
15Recurrent otitis media (HP:0000403)3.31390961
16Recurrent sinusitis (HP:0011108)3.20613952
17Abnormality of the renal medulla (HP:0100957)3.04992505
18Tubulointerstitial nephritis (HP:0001970)2.72086759
19Recurrent bronchitis (HP:0002837)2.71039640
20Impulsivity (HP:0100710)2.61984515
21Tubular atrophy (HP:0000092)2.58691224
22Molar tooth sign on MRI (HP:0002419)2.51855787
23Abnormality of midbrain morphology (HP:0002418)2.51855787
24Cholecystitis (HP:0001082)2.45717110
25Abnormal gallbladder physiology (HP:0012438)2.45717110
26Medial flaring of the eyebrow (HP:0010747)2.42698211
27Tubulointerstitial abnormality (HP:0001969)2.33837528
28Gonadotropin excess (HP:0000837)2.27066747
29Azoospermia (HP:0000027)2.26659780
30Dyschromatopsia (HP:0007641)2.08895848
31Dynein arm defect of respiratory motile cilia (HP:0012255)13.3525790
32Absent/shortened dynein arms (HP:0200106)13.3525790
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1679391
34Spastic tetraparesis (HP:0001285)1.91163862
35Tubulointerstitial fibrosis (HP:0005576)1.89698440
36Decreased central vision (HP:0007663)1.88705235
37Choroideremia (HP:0001139)1.87139570
38Postaxial foot polydactyly (HP:0001830)1.75923889
39Congenital malformation of the right heart (HP:0011723)1.73654100
40Double outlet right ventricle (HP:0001719)1.73654100
41Stage 5 chronic kidney disease (HP:0003774)1.72893289
42Polydipsia (HP:0001959)1.72002207
43Abnormal drinking behavior (HP:0030082)1.72002207
44Heterotopia (HP:0002282)1.67982959
45Bile duct proliferation (HP:0001408)1.67776232
46Abnormal biliary tract physiology (HP:0012439)1.67776232
47Neurofibrillary tangles (HP:0002185)1.64472685
48Hemorrhage of the eye (HP:0011885)1.64367555
49Congenital hepatic fibrosis (HP:0002612)1.63040600
50Abnormality of renal excretion (HP:0011036)1.60464324
51Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58309897
52Abnormality of the renal cortex (HP:0011035)1.57026163
53Sensory axonal neuropathy (HP:0003390)1.54499574
54Asymmetric septal hypertrophy (HP:0001670)1.53890666
55Aplasia/Hypoplasia of the lens (HP:0008063)1.51522163
56Short ribs (HP:0000773)1.51363964
57Decreased electroretinogram (ERG) amplitude (HP:0000654)1.51173334
58Oculomotor apraxia (HP:0000657)1.50934910
59Bell-shaped thorax (HP:0001591)1.50314566
60Bundle branch block (HP:0011710)1.44358191
61Chronic sinusitis (HP:0011109)1.42881758
62Exercise-induced myalgia (HP:0003738)1.42815962
63Abnormality of the dental root (HP:0006486)1.42147920
64Taurodontia (HP:0000679)1.42147920
65Abnormality of permanent molar morphology (HP:0011071)1.42147920
66Abnormality of the lower motor neuron (HP:0002366)1.42097745
67Fibular hypoplasia (HP:0003038)1.40917503
68Renal dysplasia (HP:0000110)1.40631963
69Postaxial hand polydactyly (HP:0001162)1.40407978
70Easy fatigability (HP:0003388)1.38499162
71Abnormality of dentin (HP:0010299)1.36876048
72Abnormal urine output (HP:0012590)1.33879461
73Cystic liver disease (HP:0006706)1.33150738
74Congenital primary aphakia (HP:0007707)1.32954624
75Facial cleft (HP:0002006)1.32941338
76Gait imbalance (HP:0002141)1.32921605
77Abnormality of the dental pulp (HP:0006479)1.32710566
78Cerebral inclusion bodies (HP:0100314)1.32356256
79Abnormality of molar morphology (HP:0011070)1.31966332
80Abnormality of molar (HP:0011077)1.31966332
81Constricted visual fields (HP:0001133)1.31793994
82Myoglobinuria (HP:0002913)1.31092294
83Deformed sella turcica (HP:0002681)1.30798222
84Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.28374518
85Cerebellar dysplasia (HP:0007033)1.27501496
86Fatigable weakness (HP:0003473)1.27011784
87Abnormality of the neuromuscular junction (HP:0003398)1.27011784
88Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.23582917
89Absent epiphyses (HP:0010577)1.23582917
90Hypercholesterolemia (HP:0003124)1.23272768
91Loss of speech (HP:0002371)1.22450953
92Amyotrophic lateral sclerosis (HP:0007354)1.21920911
93Abnormality of saccadic eye movements (HP:0000570)1.18746752
94Hyporeflexia of lower limbs (HP:0002600)1.18509134
95Pancreatic fibrosis (HP:0100732)1.18150868
96Abnormality of ocular smooth pursuit (HP:0000617)1.17645497
97Rhabdomyolysis (HP:0003201)1.17326497
98Retinal dysplasia (HP:0007973)1.17301283
99Hemiparesis (HP:0001269)1.16811555
100Broad distal phalanx of finger (HP:0009836)1.14562070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.35559961
2PDK38.35559961
3TESK16.27115497
4PDK25.40505104
5PRKD34.81903376
6ICK4.41736663
7PTK2B2.15389858
8WNK42.12210250
9STK392.05173290
10STK381.83825731
11PNCK1.63870162
12DYRK1B1.62421554
13NEK21.52383638
14PDK11.24970199
15DYRK30.89638870
16MAPK150.85496630
17IRAK10.84917684
18TYRO30.79753059
19PDPK10.78768734
20WNK10.78272615
21RIPK40.74541925
22CCNB10.72830934
23PASK0.68081331
24EEF2K0.64700221
25STK30.61769981
26TESK20.58036648
27PINK10.56661735
28TTK0.56413250
29CHEK20.55139120
30LMTK20.54356099
31MAP2K60.50677602
32IRAK20.45348363
33MUSK0.44701510
34NTRK20.44390880
35STK38L0.42302490
36CAMK1G0.40384442
37PAK10.37841088
38PRKCG0.37199415
39CHEK10.35751689
40MAP3K100.33581027
41MAPKAPK50.29382603
42MARK20.26771319
43PAK20.25699181
44CAMKK10.24646022
45MTOR0.24047100
46ATM0.23264814
47PLK40.22283572
48BRSK20.22187079
49ATR0.21897131
50PAK40.21663553
51WEE10.21316215
52PRKCZ0.20260615
53CDK150.17218742
54PRKAA10.16979631
55NEK60.16309979
56PRKCQ0.15729827
57CDK180.14475279
58CDK11A0.13082793
59PRKG20.12089751
60RPS6KB10.12065392
61BRSK10.11697230
62PLK10.10993445
63CDC70.10932579
64YES10.09670711
65CDK140.09339645
66BRAF0.08911477
67RPS6KA10.07339969
68CSNK2A10.06276259
69GSK3B0.06082477
70MARK30.05748228
71PDGFRB0.05702823
72CSF1R0.04766024
73STK100.04573962
74STK110.04083202
75PRKG10.03903937
76PRKACG0.03274623
77PRKCD0.02830870
78CLK10.02820871
79CAMK2A0.02757797
80PKN10.02567281
81MAPK80.02160798
82ZAP700.01887085
83PIM10.01792576
84CDK10.01703723
85CDK60.01348815
86CDK20.01191997
87PRKCA0.00857359
88EGFR0.00826292
89PRKCB0.00801656
90CSNK2A20.00482552
91WNK3-0.0340324
92MAP3K5-0.0300272
93RPS6KA3-0.0268357
94MAP3K1-0.0228329
95PAK6-0.0223563
96PRKACB-0.0209912
97AURKA-0.0137200
98MAP3K4-0.0135476
99EPHB1-0.0109517
100CSNK1D-0.0073446

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.67091017
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.47619228
3Pyruvate metabolism_Homo sapiens_hsa006203.33491334
4Vitamin B6 metabolism_Homo sapiens_hsa007503.32949455
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26964997
6Linoleic acid metabolism_Homo sapiens_hsa005913.16323967
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.85673061
8Glucagon signaling pathway_Homo sapiens_hsa049222.54837905
9Propanoate metabolism_Homo sapiens_hsa006402.47889764
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.39359201
11Basal transcription factors_Homo sapiens_hsa030222.20380474
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17448843
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00045427
14Glycerolipid metabolism_Homo sapiens_hsa005611.98481075
15Selenocompound metabolism_Homo sapiens_hsa004501.96175225
16PPAR signaling pathway_Homo sapiens_hsa033201.87574030
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85790920
18Pentose phosphate pathway_Homo sapiens_hsa000301.77340632
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.76749454
20Fructose and mannose metabolism_Homo sapiens_hsa000511.65282577
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65055158
22Fat digestion and absorption_Homo sapiens_hsa049751.59969274
23Oocyte meiosis_Homo sapiens_hsa041141.58047546
24Mineral absorption_Homo sapiens_hsa049781.55267626
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51920423
26Ether lipid metabolism_Homo sapiens_hsa005651.50982092
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.47951832
28Fatty acid degradation_Homo sapiens_hsa000711.47463417
29Fatty acid metabolism_Homo sapiens_hsa012121.46474888
30Amphetamine addiction_Homo sapiens_hsa050311.46039883
31Carbon metabolism_Homo sapiens_hsa012001.44113159
32Dorso-ventral axis formation_Homo sapiens_hsa043201.39656048
33Cardiac muscle contraction_Homo sapiens_hsa042601.31304864
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23868624
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21650074
36Fanconi anemia pathway_Homo sapiens_hsa034601.12764364
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.09323761
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07855000
39Renin secretion_Homo sapiens_hsa049241.04225643
40Antigen processing and presentation_Homo sapiens_hsa046121.03801124
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99731648
42Glutathione metabolism_Homo sapiens_hsa004800.99713646
43Purine metabolism_Homo sapiens_hsa002300.96235361
44Collecting duct acid secretion_Homo sapiens_hsa049660.95822550
45Hedgehog signaling pathway_Homo sapiens_hsa043400.94631038
46Biosynthesis of amino acids_Homo sapiens_hsa012300.94256853
47Huntingtons disease_Homo sapiens_hsa050160.92325338
48Chemical carcinogenesis_Homo sapiens_hsa052040.86690275
49Arachidonic acid metabolism_Homo sapiens_hsa005900.85378667
50Insulin secretion_Homo sapiens_hsa049110.83632057
51mRNA surveillance pathway_Homo sapiens_hsa030150.83396333
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.81318251
53Bile secretion_Homo sapiens_hsa049760.79159361
54Thyroid hormone synthesis_Homo sapiens_hsa049180.74727923
55Estrogen signaling pathway_Homo sapiens_hsa049150.71793539
56Long-term potentiation_Homo sapiens_hsa047200.70080174
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67162671
58RNA transport_Homo sapiens_hsa030130.62967591
59Systemic lupus erythematosus_Homo sapiens_hsa053220.62583835
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.60439295
61Renin-angiotensin system_Homo sapiens_hsa046140.59019328
62Legionellosis_Homo sapiens_hsa051340.58476487
63Pancreatic secretion_Homo sapiens_hsa049720.57515839
64ABC transporters_Homo sapiens_hsa020100.54576166
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54062719
66Salivary secretion_Homo sapiens_hsa049700.53663562
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51378933
68Synaptic vesicle cycle_Homo sapiens_hsa047210.51322019
69Gastric acid secretion_Homo sapiens_hsa049710.49251112
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48772299
71Calcium signaling pathway_Homo sapiens_hsa040200.48552021
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48512752
73Protein digestion and absorption_Homo sapiens_hsa049740.47706343
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.46045121
75Endocytosis_Homo sapiens_hsa041440.45761106
76AMPK signaling pathway_Homo sapiens_hsa041520.45306600
77Sulfur metabolism_Homo sapiens_hsa009200.42829987
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41973061
79Inositol phosphate metabolism_Homo sapiens_hsa005620.41930568
80Metabolic pathways_Homo sapiens_hsa011000.38845103
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38458069
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37619427
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36764053
84VEGF signaling pathway_Homo sapiens_hsa043700.32446144
85Alcoholism_Homo sapiens_hsa050340.30574812
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28947636
87cAMP signaling pathway_Homo sapiens_hsa040240.28361874
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28211531
89Circadian entrainment_Homo sapiens_hsa047130.25994319
90Taste transduction_Homo sapiens_hsa047420.25495099
91Pyrimidine metabolism_Homo sapiens_hsa002400.24612076
92Cocaine addiction_Homo sapiens_hsa050300.18331883
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10875731
94HIF-1 signaling pathway_Homo sapiens_hsa040660.10012773
95N-Glycan biosynthesis_Homo sapiens_hsa005100.10009472
96Wnt signaling pathway_Homo sapiens_hsa043100.09243049
97Salmonella infection_Homo sapiens_hsa051320.08289492
98Basal cell carcinoma_Homo sapiens_hsa052170.07060982
99B cell receptor signaling pathway_Homo sapiens_hsa046620.07022115
100Glutamatergic synapse_Homo sapiens_hsa047240.03766539

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