ACTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)5.36825254
2chondrocyte proliferation (GO:0035988)5.12623412
3endodermal cell differentiation (GO:0035987)4.90118245
4wound healing, spreading of epidermal cells (GO:0035313)4.72884798
5positive regulation of endothelial cell apoptotic process (GO:2000353)4.66471857
6skin morphogenesis (GO:0043589)4.55343597
7negative regulation of fatty acid transport (GO:2000192)4.33499521
8collagen fibril organization (GO:0030199)4.28049998
9hypotonic response (GO:0006971)4.04551576
10COPI coating of Golgi vesicle (GO:0048205)3.97146538
11Golgi transport vesicle coating (GO:0048200)3.97146538
12protein heterotrimerization (GO:0070208)3.92165093
13wound healing, spreading of cells (GO:0044319)3.89503643
14epithelial cell-cell adhesion (GO:0090136)3.85206544
15hippo signaling (GO:0035329)3.71679473
16regulation of hippo signaling (GO:0035330)3.70672468
17barbed-end actin filament capping (GO:0051016)3.60078239
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.57621550
19plasma membrane repair (GO:0001778)3.56848656
20mesodermal cell differentiation (GO:0048333)3.54577342
21stress fiber assembly (GO:0043149)3.54018450
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.44804853
23axon extension involved in axon guidance (GO:0048846)3.44804853
24apoptotic cell clearance (GO:0043277)3.42054598
25substrate-dependent cell migration (GO:0006929)3.38965498
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33909549
27* cell-substrate junction assembly (GO:0007044)3.30609303
28protein retention in ER lumen (GO:0006621)3.29625392
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28577095
30polarized epithelial cell differentiation (GO:0030859)3.28454468
31basement membrane organization (GO:0071711)3.25163689
32desmosome organization (GO:0002934)3.24228007
33protein localization to cell surface (GO:0034394)3.23962062
34cellular response to vitamin D (GO:0071305)3.22964393
35cell migration involved in sprouting angiogenesis (GO:0002042)3.19260804
36endocardial cushion development (GO:0003197)3.17063216
37positive regulation of receptor recycling (GO:0001921)3.14587628
38cellular response to interferon-alpha (GO:0035457)3.14290893
39positive regulation of blood vessel endothelial cell migration (GO:0043536)3.12605987
40regulation of early endosome to late endosome transport (GO:2000641)3.12587527
41membrane raft organization (GO:0031579)3.11889736
42regulation of tight junction assembly (GO:2000810)3.11570710
43pinocytosis (GO:0006907)3.11057974
44hemidesmosome assembly (GO:0031581)3.06521525
45regulation of integrin activation (GO:0033623)3.05974393
46* adherens junction assembly (GO:0034333)3.01540952
47substrate adhesion-dependent cell spreading (GO:0034446)3.01187785
48cytoskeletal anchoring at plasma membrane (GO:0007016)2.97680405
49vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.97447596
50sequestering of extracellular ligand from receptor (GO:0035581)2.97366477
51positive regulation of epithelial to mesenchymal transition (GO:0010718)2.97025278
52establishment of apical/basal cell polarity (GO:0035089)2.97009164
53actin filament depolymerization (GO:0030042)2.96972369
54cellular response to vitamin (GO:0071295)2.96239085
55heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.94253902
56blood vessel endothelial cell migration (GO:0043534)2.94042703
57hyaluronan catabolic process (GO:0030214)2.90586232
58apoptotic process involved in morphogenesis (GO:0060561)2.90213213
59extracellular fibril organization (GO:0043206)2.89547867
60collagen metabolic process (GO:0032963)2.88237343
61bone trabecula formation (GO:0060346)2.87233058
62cortical actin cytoskeleton organization (GO:0030866)2.86637434
63cell migration involved in heart development (GO:0060973)2.86018017
64heterochromatin organization (GO:0070828)2.86010081
65type B pancreatic cell proliferation (GO:0044342)2.84698006
66extracellular matrix disassembly (GO:0022617)2.81645049
67vascular endothelial growth factor signaling pathway (GO:0038084)2.81626112
68collagen catabolic process (GO:0030574)2.79497364
69extracellular matrix assembly (GO:0085029)2.79473745
70fibril organization (GO:0097435)2.77067297
71planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75964281
72paraxial mesoderm development (GO:0048339)2.75298217
73membrane protein ectodomain proteolysis (GO:0006509)2.74352602
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.73309337
75negative regulation of focal adhesion assembly (GO:0051895)2.71816301
76negative regulation of cell junction assembly (GO:1901889)2.71816301
77negative regulation of adherens junction organization (GO:1903392)2.71816301
78platelet aggregation (GO:0070527)2.71603473
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71563610
80muscle cell migration (GO:0014812)2.70852589
81negative regulation of anoikis (GO:2000811)2.70690181
82positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.70256182
83semaphorin-plexin signaling pathway (GO:0071526)2.70212479
84renal filtration (GO:0097205)2.69659293
85response to laminar fluid shear stress (GO:0034616)2.69080081
86endocytic recycling (GO:0032456)2.69042340
87multicellular organismal macromolecule metabolic process (GO:0044259)2.66111357
88negative regulation of smooth muscle cell migration (GO:0014912)2.65468234
89regulation of SMAD protein import into nucleus (GO:0060390)2.64576057
90mesenchymal-epithelial cell signaling (GO:0060638)2.64470180
91mRNA transcription (GO:0009299)2.62685023
92negative regulation of chondrocyte differentiation (GO:0032331)2.61295488
93atrioventricular valve morphogenesis (GO:0003181)2.61131506
94positive regulation of endothelial cell migration (GO:0010595)2.60533321
95positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59387379
96response to fluid shear stress (GO:0034405)2.58221196
97protein hydroxylation (GO:0018126)2.56767162
98positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.56242943
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56000883
100positive regulation of SMAD protein import into nucleus (GO:0060391)2.55489901
101protein localization to endosome (GO:0036010)2.55156798
102cortical cytoskeleton organization (GO:0030865)2.54658762
103positive regulation of osteoblast proliferation (GO:0033690)2.54307644
104metanephric mesenchyme development (GO:0072075)2.54080336
105virion attachment to host cell (GO:0019062)2.54024560
106adhesion of symbiont to host cell (GO:0044650)2.54024560
107* platelet degranulation (GO:0002576)2.53676029
108multicellular organismal catabolic process (GO:0044243)2.53495559
109peptidyl-proline hydroxylation (GO:0019511)2.52820870
110positive regulation of extracellular matrix organization (GO:1903055)2.52274228
111positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50786742
112regulation of extracellular matrix disassembly (GO:0010715)2.50368664
113positive regulation of macrophage activation (GO:0043032)2.50344135
114regulation of transforming growth factor beta1 production (GO:0032908)2.50063011
115endothelial cell morphogenesis (GO:0001886)2.48581996
116branching involved in salivary gland morphogenesis (GO:0060445)2.48477687
117positive regulation of natural killer cell differentiation (GO:0032825)2.48426685
118dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47886766
119multicellular organismal metabolic process (GO:0044236)2.47651035
120craniofacial suture morphogenesis (GO:0097094)2.47143110
121regulation of transforming growth factor beta2 production (GO:0032909)2.46933676
122kidney mesenchyme development (GO:0072074)2.46930719
123* extracellular matrix organization (GO:0030198)2.45919463
124regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.45880267
125* extracellular structure organization (GO:0043062)2.44801904
126positive regulation of epithelial cell migration (GO:0010634)2.44563310
127negative regulation of homotypic cell-cell adhesion (GO:0034111)2.44269596
128integrin-mediated signaling pathway (GO:0007229)2.43537692
129insulin-like growth factor receptor signaling pathway (GO:0048009)2.43125415
130* cell junction assembly (GO:0034329)2.42945249
131retina vasculature morphogenesis in camera-type eye (GO:0061299)2.42193206
132mammary gland epithelial cell proliferation (GO:0033598)2.42097166
133embryonic camera-type eye development (GO:0031076)2.38761386
134apoptotic process involved in development (GO:1902742)2.37813386
135establishment of monopolar cell polarity (GO:0061162)2.37255304
136establishment or maintenance of monopolar cell polarity (GO:0061339)2.37255304
137negative regulation of cartilage development (GO:0061037)2.36546434
138* cell-substrate adherens junction assembly (GO:0007045)2.35084372
139* focal adhesion assembly (GO:0048041)2.35084372
140regulation of G0 to G1 transition (GO:0070316)2.33563686
141regulation of gene silencing by RNA (GO:0060966)2.32646729
142regulation of posttranscriptional gene silencing (GO:0060147)2.32646729
143regulation of gene silencing by miRNA (GO:0060964)2.32646729
144regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.30169743
145nuclear pore complex assembly (GO:0051292)2.28107477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.79611709
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.31616460
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.25273469
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.10329010
5RARG_19884340_ChIP-ChIP_MEFs_Mouse4.01375710
6* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.68017290
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.57903285
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42022948
9* CLOCK_20551151_ChIP-Seq_293T_Human2.40767856
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35745047
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.29066493
12* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.27917473
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.26758816
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14637766
15* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08325260
16* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08325260
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98542967
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92201938
19SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.90057202
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89143668
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.86216521
22ATF3_27146783_Chip-Seq_COLON_Human1.85622748
23BRD4_25478319_ChIP-Seq_HGPS_Human1.85095792
24* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84596662
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.84275550
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75119279
27CJUN_26792858_Chip-Seq_BT549_Human1.74754015
28* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74247096
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72114465
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.70189383
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68230452
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.66015192
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.65418359
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63495036
35* RACK7_27058665_Chip-Seq_MCF-7_Human1.63140477
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59241222
37UBF1/2_26484160_Chip-Seq_HMECs_Human1.52151027
38* KDM2B_26808549_Chip-Seq_DND41_Human1.51426691
39ZNF263_19887448_ChIP-Seq_K562_Human1.51003075
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50919371
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49489791
42* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49488957
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.48870829
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48712470
45MYC_22102868_ChIP-Seq_BL_Human1.48518338
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48009868
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44337501
48* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.44241858
49TP53_22127205_ChIP-Seq_IMR90_Human1.43551646
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.41411686
51* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37634188
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36564078
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35354026
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34998456
55TCF7_22412390_ChIP-Seq_EML_Mouse1.33726160
56* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30772711
57* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30367228
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29322349
59* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28920721
60* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27679128
61* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27202215
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.26373570
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26256716
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25433816
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24409830
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24382118
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24259928
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24211658
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23186046
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22826095
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22132502
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21714900
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21658679
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21496942
75* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21350951
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.20195543
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.20195543
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20183693
79SOX2_20726797_ChIP-Seq_SW620_Human1.19576788
80JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19545242
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19324744
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17492814
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17233794
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14905498
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.13694692
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13521888
87* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12556099
88* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11895764
89NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11045805
90NCOR1_26117541_ChIP-Seq_K562_Human1.10117251
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10054171
92LXR_22292898_ChIP-Seq_THP-1_Human1.09404730
93* TP53_23651856_ChIP-Seq_MEFs_Mouse1.09350777
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.09108958
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08618099
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08618099
97* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08383438
98* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08325726
99* KDM2B_26808549_Chip-Seq_K562_Human1.08282941
100VDR_24763502_ChIP-Seq_THP-1_Human1.06950366
101* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06639297
102VDR_21846776_ChIP-Seq_THP-1_Human1.06147941
103* KLF5_25053715_ChIP-Seq_YYC3_Human1.05600883
104* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01849441
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.01558972
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01485133
107* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01375510
108NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00972913
109TP53_20018659_ChIP-ChIP_R1E_Mouse1.00831676
110GATA2_21666600_ChIP-Seq_HMVEC_Human1.00622514
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00586485
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99909996
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99909996
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99909996
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98530425
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98097409
117MAF_26560356_Chip-Seq_TH1_Human0.97692730
118* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97626981
119CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97608926
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97514252
121SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93308697
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.92357161
123* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89340664
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87620256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.49241243
2MP0003705_abnormal_hypodermis_morpholog4.35947019
3MP0005275_abnormal_skin_tensile3.71586456
4MP0010352_gastrointestinal_tract_polyps3.52796916
5MP0005623_abnormal_meninges_morphology3.40345096
6MP0003566_abnormal_cell_adhesion3.27010339
7MP0003279_aneurysm3.14706232
8MP0005503_abnormal_tendon_morphology2.62353305
9MP0004272_abnormal_basement_membrane2.56730789
10MP0003091_abnormal_cell_migration2.43003430
11MP0005023_abnormal_wound_healing2.41290743
12MP0001958_emphysema2.37231881
13MP0001348_abnormal_lacrimal_gland2.29156700
14MP0003950_abnormal_plasma_membrane2.27084999
15MP0005076_abnormal_cell_differentiation2.06633288
16MP0005257_abnormal_intraocular_pressure2.01670199
17MP0002877_abnormal_melanocyte_morpholog1.97081910
18MP0009053_abnormal_anal_canal1.89823269
19MP0010030_abnormal_orbit_morphology1.89253871
20MP0006054_spinal_hemorrhage1.84938340
21MP0010234_abnormal_vibrissa_follicle1.77960446
22MP0000733_abnormal_muscle_development1.76512626
23MP0002060_abnormal_skin_morphology1.69594925
24MP0003191_abnormal_cellular_cholesterol1.67400995
25MP0003300_gastrointestinal_ulcer1.62216633
26MP0000537_abnormal_urethra_morphology1.58274845
27MP0005508_abnormal_skeleton_morphology1.58230298
28MP0009384_cardiac_valve_regurgitation1.58137724
29MP0003941_abnormal_skin_development1.57645046
30MP0003385_abnormal_body_wall1.53208142
31MP0004858_abnormal_nervous_system1.52378339
32MP0000767_abnormal_smooth_muscle1.43244401
33MP0005409_darkened_coat_color1.41787796
34MP0001243_abnormal_dermal_layer1.38726674
35MP0000858_altered_metastatic_potential1.37721537
36MP0005058_abnormal_lysosome_morphology1.36550934
37MP0000751_myopathy1.33324333
38MP0003303_peritoneal_inflammation1.32569497
39MP0003045_fibrosis1.31972292
40MP0000762_abnormal_tongue_morphology1.30717460
41MP0002295_abnormal_pulmonary_circulatio1.30171471
42MP0008260_abnormal_autophagy1.27410364
43MP0003453_abnormal_keratinocyte_physiol1.26094999
44MP0003828_pulmonary_edema1.25082835
45MP0000579_abnormal_nail_morphology1.22643198
46MP0009840_abnormal_foam_cell1.21835743
47MP0003448_altered_tumor_morphology1.20801949
48MP0003115_abnormal_respiratory_system1.20285268
49MP0009278_abnormal_bone_marrow1.17888721
50MP0000428_abnormal_craniofacial_morphol1.16874578
51MP0002896_abnormal_bone_mineralization1.16843811
52MP0005451_abnormal_body_composition1.12455205
53MP0001849_ear_inflammation1.12335994
54MP0005164_abnormal_response_to1.10793305
55MP0005367_renal/urinary_system_phenotyp1.10555822
56MP0000516_abnormal_urinary_system1.10555822
57MP0005464_abnormal_platelet_physiology1.09797199
58MP0005390_skeleton_phenotype1.09469355
59MP0002282_abnormal_trachea_morphology1.09267456
60MP0005595_abnormal_vascular_smooth1.08450138
61MP0003283_abnormal_digestive_organ1.07639332
62MP0000534_abnormal_ureter_morphology1.07375761
63MP0001915_intracranial_hemorrhage1.02783278
64MP0004510_myositis1.01796495
65MP0001879_abnormal_lymphatic_vessel1.01785679
66MP0002925_abnormal_cardiovascular_devel1.00076891
67MP0003942_abnormal_urinary_system0.99891273
68MP0009250_abnormal_appendicular_skeleto0.99035535
69MP0003755_abnormal_palate_morphology0.97634705
70MP0002168_other_aberrant_phenotype0.94665707
71MP0009780_abnormal_chondrocyte_physiolo0.94240683
72MP0004197_abnormal_fetal_growth/weight/0.94201543
73MP0001614_abnormal_blood_vessel0.93784345
74MP0001216_abnormal_epidermal_layer0.93690070
75MP0003436_decreased_susceptibility_to0.91684751
76MP0001299_abnormal_eye_distance/0.91629692
77MP0002932_abnormal_joint_morphology0.91344385
78MP0010307_abnormal_tumor_latency0.90847106
79MP0001533_abnormal_skeleton_physiology0.89289907
80MP0001542_abnormal_bone_strength0.88827320
81MP0004233_abnormal_muscle_weight0.88802966
82MP0004947_skin_inflammation0.87390255
83MP0004808_abnormal_hematopoietic_stem0.86691464
84MP0002933_joint_inflammation0.86624219
85MP0000432_abnormal_head_morphology0.86558203
86MP0000750_abnormal_muscle_regeneration0.85867635
87MP0002254_reproductive_system_inflammat0.85137047
88MP0006138_congestive_heart_failure0.84100861
89MP0002113_abnormal_skeleton_development0.83731263
90MP0002128_abnormal_blood_circulation0.83700437
91MP0002086_abnormal_extraembryonic_tissu0.83247572
92MP0000163_abnormal_cartilage_morphology0.83056384
93MP0002697_abnormal_eye_size0.82761398
94MP0000343_altered_response_to0.82484344
95MP0010368_abnormal_lymphatic_system0.82002381
96MP0002998_abnormal_bone_remodeling0.81552184
97MP0002796_impaired_skin_barrier0.81346763
98MP0005165_increased_susceptibility_to0.81073703
99MP0003935_abnormal_craniofacial_develop0.80626383
100MP0002089_abnormal_postnatal_growth/wei0.80433027
101MP0002115_abnormal_skeleton_extremities0.80177934
102MP0000013_abnormal_adipose_tissue0.80110215
103MP0005501_abnormal_skin_physiology0.78082353
104MP0002084_abnormal_developmental_patter0.77021385
105MP0002111_abnormal_tail_morphology0.76327021
106MP0003937_abnormal_limbs/digits/tail_de0.76235723
107MP0010771_integument_phenotype0.75227825
108MP0000467_abnormal_esophagus_morphology0.74554849
109MP0000350_abnormal_cell_proliferation0.74210613
110MP0001175_abnormal_lung_morphology0.74047926
111MP0003984_embryonic_growth_retardation0.73371660
112MP0005193_abnormal_anterior_eye0.73315560
113MP0001346_abnormal_lacrimal_gland0.72950873
114MP0002088_abnormal_embryonic_growth/wei0.72868398
115MP0000627_abnormal_mammary_gland0.72583033
116MP0004883_abnormal_blood_vessel0.71622320
117MP0003795_abnormal_bone_structure0.70641803
118MP0000759_abnormal_skeletal_muscle0.69793189
119MP0005621_abnormal_cell_physiology0.68908454
120MP0003329_amyloid_beta_deposits0.68669158
121MP0005197_abnormal_uvea_morphology0.68633513
122MP0001672_abnormal_embryogenesis/_devel0.67886802
123MP0005380_embryogenesis_phenotype0.67886802
124MP0000003_abnormal_adipose_tissue0.67808185
125MP0002085_abnormal_embryonic_tissue0.67434191
126MP0000685_abnormal_immune_system0.67262919
127MP0000249_abnormal_blood_vessel0.67127104
128MP0008007_abnormal_cellular_replicative0.67104327
129MP0010630_abnormal_cardiac_muscle0.66609474
130MP0004185_abnormal_adipocyte_glucose0.66533075
131MP0005375_adipose_tissue_phenotype0.65789277
132MP0000678_abnormal_parathyroid_gland0.64893946
133MP0003172_abnormal_lysosome_physiology0.63925999
134MP0000462_abnormal_digestive_system0.63454690
135MP0000749_muscle_degeneration0.62223642
136MP0003075_altered_response_to0.61307321

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.60028834
2Protrusio acetabuli (HP:0003179)6.43372115
3Shallow orbits (HP:0000586)4.46672198
4Atrophic scars (HP:0001075)4.28490076
5Peritonitis (HP:0002586)4.25140961
6Aortic dissection (HP:0002647)4.17926877
7Cerebral aneurysm (HP:0004944)3.98131264
8Ankle contracture (HP:0006466)3.85442523
9Cervical subluxation (HP:0003308)3.69419439
10Dilatation of the ascending aorta (HP:0005111)3.63526270
11Aortic aneurysm (HP:0004942)3.49463968
12Fragile skin (HP:0001030)3.36031625
13Genu recurvatum (HP:0002816)3.28564590
14Mitral valve prolapse (HP:0001634)3.14084812
15Soft skin (HP:0000977)3.07340532
16Bladder diverticulum (HP:0000015)3.01170242
17Wrist flexion contracture (HP:0001239)2.91118720
18Abnormality of dentin (HP:0010299)2.87686284
19Increased density of long bones (HP:0006392)2.83733248
20Wormian bones (HP:0002645)2.80139597
21Radial bowing (HP:0002986)2.74856360
22Short nail (HP:0001799)2.73348844
23Osteolytic defects of the hand bones (HP:0009699)2.72052071
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.72052071
25Increased connective tissue (HP:0009025)2.69381033
26Vertebral compression fractures (HP:0002953)2.67396355
27Blue sclerae (HP:0000592)2.66216033
28Ulnar bowing (HP:0003031)2.65885490
29Neonatal short-limb short stature (HP:0008921)2.63772185
30Broad face (HP:0000283)2.56930453
31Fused cervical vertebrae (HP:0002949)2.56411965
32Distal upper limb amyotrophy (HP:0007149)2.55030412
33Upper limb amyotrophy (HP:0009129)2.55030412
34Broad metatarsal (HP:0001783)2.50717056
35Bowel diverticulosis (HP:0005222)2.50667901
36Spinal rigidity (HP:0003306)2.50015615
37Abnormality of the calcaneus (HP:0008364)2.47289969
38Camptodactyly of toe (HP:0001836)2.46622546
39Aneurysm (HP:0002617)2.43945829
40Disproportionate tall stature (HP:0001519)2.43092610
41Increased variability in muscle fiber diameter (HP:0003557)2.42458287
42Distal lower limb amyotrophy (HP:0008944)2.42126796
43Bowing of the arm (HP:0006488)2.36205134
44Bowed forearm bones (HP:0003956)2.36205134
45Mesomelia (HP:0003027)2.35055800
46Biconcave vertebral bodies (HP:0004586)2.31994919
47Slender build (HP:0001533)2.30397402
48Hyperacusis (HP:0010780)2.28146534
49Tibial bowing (HP:0002982)2.27328197
50Natal tooth (HP:0000695)2.26937320
51Achilles tendon contracture (HP:0001771)2.26114326
52Distal lower limb muscle weakness (HP:0009053)2.24030014
53Abnormality of skeletal muscle fiber size (HP:0012084)2.22399498
54Vascular tortuosity (HP:0004948)2.22099409
55Aortic regurgitation (HP:0001659)2.20276985
56Deviation of the hallux (HP:0010051)2.19639848
57Elbow flexion contracture (HP:0002987)2.19088853
58Selective tooth agenesis (HP:0001592)2.17010716
59Hallux valgus (HP:0001822)2.14953339
60Abnormality of the peritoneum (HP:0002585)2.14847953
61Abnormality of the acetabulum (HP:0003170)2.14510016
62Spinal cord lesions (HP:0100561)2.13788716
63Syringomyelia (HP:0003396)2.13788716
64Thin bony cortex (HP:0002753)2.12322851
65Scapular winging (HP:0003691)2.10469865
66Right ventricular cardiomyopathy (HP:0011663)2.08699351
67Mitral stenosis (HP:0001718)2.08065845
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06536122
69Short 4th metacarpal (HP:0010044)2.06536122
70Difficulty climbing stairs (HP:0003551)2.06132487
71Menorrhagia (HP:0000132)2.05993696
72Hyperextensible skin (HP:0000974)2.04638673
73Abnormality of the Achilles tendon (HP:0005109)2.04316632
74Persistence of primary teeth (HP:0006335)2.03446688
75Abnormal delivery (HP:0001787)2.03382469
76Type 1 muscle fiber predominance (HP:0003803)2.00313840
77Spinal cord compression (HP:0002176)1.98591143
78Generalized amyotrophy (HP:0003700)1.98531412
79Joint contractures involving the joints of the feet (HP:0100492)1.97551315
80Flexion contracture of toe (HP:0005830)1.97551315
81Long toe (HP:0010511)1.96752503
82Absent frontal sinuses (HP:0002688)1.95282757
83Myocardial infarction (HP:0001658)1.93390528
84Mitral regurgitation (HP:0001653)1.91443503
85Abnormality of oral frenula (HP:0000190)1.90510071
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.89944881
87Arterial tortuosity (HP:0005116)1.88579511
88Abnormality of the distal phalanges of the toes (HP:0010182)1.86114130
89Ectopia lentis (HP:0001083)1.85371524
90Hand muscle atrophy (HP:0009130)1.85067151
91Mildly elevated creatine phosphokinase (HP:0008180)1.84818620
92Joint stiffness (HP:0001387)1.84364146
93Thick nail (HP:0001805)1.84244846
94Abnormal ossification of hand bones (HP:0005921)1.83717317
95Cardiovascular calcification (HP:0011915)1.83354280
96Coxa vara (HP:0002812)1.82481668
97Tarsal synostosis (HP:0008368)1.81904974
98Joint laxity (HP:0001388)1.80352046
99* Increased mean platelet volume (HP:0011877)1.79510807
100Bronchomalacia (HP:0002780)1.78892940
101Broad long bones (HP:0005622)1.78062792
102Lower limb amyotrophy (HP:0007210)1.77930169
103Trismus (HP:0000211)1.77413217
104Buphthalmos (HP:0000557)1.76669799
105Aortic valve stenosis (HP:0001650)1.76662725
106Short humerus (HP:0005792)1.76581245
107Missing ribs (HP:0000921)1.75940311
108Wide anterior fontanel (HP:0000260)1.74109453
109Subacute progressive viral hepatitis (HP:0006572)1.73324974
110Femoral bowing (HP:0002980)1.72662235
111Nail dystrophy (HP:0008404)1.72289640
112Broad thumb (HP:0011304)1.71143101
113Overgrowth (HP:0001548)1.71111472
114Deviation of the thumb (HP:0009603)1.70435877
115Ankyloglossia (HP:0010296)1.69937703
116Knee flexion contracture (HP:0006380)1.69388144
117Reduced subcutaneous adipose tissue (HP:0003758)1.68776216
118* Abnormal platelet volume (HP:0011876)1.68513343
119Round ear (HP:0100830)1.68343226
120Abnormality of carpal bone ossification (HP:0006257)1.67876243
121Follicular hyperkeratosis (HP:0007502)1.67796285
122Hypoventilation (HP:0002791)1.67240764
123Abnormal vertebral ossification (HP:0100569)1.67122151
124Fragile nails (HP:0001808)1.66742508
125Infantile muscular hypotonia (HP:0008947)1.65734692
126Flat acetabular roof (HP:0003180)1.65564489
127Nonimmune hydrops fetalis (HP:0001790)1.64626058
128Spondylolisthesis (HP:0003302)1.64429254
129Long palpebral fissure (HP:0000637)1.64282228
130Asymmetry of the thorax (HP:0001555)1.63835444
131Milia (HP:0001056)1.63761898
132Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63176455
133Alopecia of scalp (HP:0002293)1.60864604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.88133097
2TRIB33.91642828
3EPHA23.78262279
4PKN23.00834666
5DDR22.96208550
6PDGFRA2.75090052
7LATS12.44666116
8BMX2.23412882
9CDK122.23230771
10LATS22.21009130
11IRAK32.04207564
12SMG12.01743313
13RIPK12.00038012
14TRPM71.97405946
15PAK21.93677595
16LRRK21.93124045
17PTK61.89545733
18MST1R1.86475009
19ERN11.86288549
20STK101.74751710
21TESK11.71206954
22EEF2K1.71112973
23EPHB21.68268471
24PAK41.64141097
25DMPK1.54692608
26MAP3K101.45523713
27* PTK21.38454068
28FER1.36891475
29PAK31.29253138
30STK31.28094628
31ARAF1.27734586
32RPS6KA41.26543815
33LMTK21.25584906
34STK381.25510016
35PRPF4B1.20835966
36MTOR1.16646996
37TAOK21.15423728
38RPS6KB21.14696410
39PDGFRB1.13724099
40MAP3K61.13351980
41ALK1.07811755
42FGFR11.03134211
43EPHB11.01934974
44PIM20.99250334
45ZAP700.99127226
46LIMK10.98480453
47MOS0.97306232
48MAP3K140.96257609
49JAK30.95988610
50ILK0.95299453
51MAP3K80.94295629
52SIK10.94108586
53MET0.93535935
54PTK2B0.92528504
55NEK90.88996733
56CDK60.88459095
57KSR20.81260620
58MAP3K130.80843282
59CSK0.79005723
60STK38L0.78790730
61PRKG20.78489587
62MAP3K30.77852663
63ERBB30.74862906
64FGFR40.71868318
65ROCK10.71306675
66CHUK0.69479443
67TBK10.68042578
68PAK10.67808125
69EPHA30.67338978
70SCYL20.66574652
71MAP2K10.64814106
72TGFBR20.58446551
73MAP3K10.57304207
74ROCK20.56824365
75* INSR0.56341914
76DAPK30.56132806
77FLT30.55858338
78MAP2K30.55790332
79HCK0.55665298
80MYLK0.54586672
81RET0.54424273
82CDC42BPA0.53412902
83GSK3A0.51840690
84TYRO30.51713860
85FGR0.51017347
86IKBKB0.49526334
87MAP3K110.49313074
88MELK0.48965063
89MAPKAPK20.48604974
90PRKD20.48184110
91CDK80.47554021
92JAK10.47322457
93TESK20.47206023
94PDPK10.47138807
95ICK0.45211228
96TGFBR10.44621875
97SRC0.44124842
98TIE10.43961882
99CLK10.43591686
100EGFR0.43545811
101NTRK10.43516433
102TAOK10.43177895
103FGFR30.43119260
104FRK0.42763530
105MST40.42326936
106NEK20.41853217
107MAPKAPK30.41001585
108ABL20.40113752
109RPS6KC10.40094514
110RPS6KL10.40094514
111DYRK1B0.40046008
112MARK20.39906901
113PRKD30.39599161
114ERBB40.38520623
115PAK60.38401596
116PRKCH0.38043685
117MAP3K90.37311188
118ABL10.37294622
119RPS6KA60.36832514
120NME20.36667121
121RPS6KA20.35991002
122PIK3CA0.35925311
123MAPK70.33409629
124PIK3CG0.33065993
125CDK90.30691853
126MAP3K20.30151259
127BRAF0.29629965
128CAMK2G0.29558076
129PRKD10.29529335
130KSR10.28881387

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.95023253
2* Focal adhesion_Homo sapiens_hsa045102.52454572
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.46067793
4Proteoglycans in cancer_Homo sapiens_hsa052052.35459688
5Bladder cancer_Homo sapiens_hsa052192.24850207
6Small cell lung cancer_Homo sapiens_hsa052222.21682910
7* Adherens junction_Homo sapiens_hsa045202.21658066
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.02027820
9Hippo signaling pathway_Homo sapiens_hsa043901.91491975
10* Amoebiasis_Homo sapiens_hsa051461.87097301
11MicroRNAs in cancer_Homo sapiens_hsa052061.84857800
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.83174218
13Chronic myeloid leukemia_Homo sapiens_hsa052201.80044524
14Shigellosis_Homo sapiens_hsa051311.78467479
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74589425
16* Leukocyte transendothelial migration_Homo sapiens_hsa046701.70028675
17* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64507528
18Other glycan degradation_Homo sapiens_hsa005111.63072756
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61196248
20TGF-beta signaling pathway_Homo sapiens_hsa043501.59454328
21* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.59278925
22p53 signaling pathway_Homo sapiens_hsa041151.58413493
23Viral myocarditis_Homo sapiens_hsa054161.58063247
24Malaria_Homo sapiens_hsa051441.55912937
25Leishmaniasis_Homo sapiens_hsa051401.49693335
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45285679
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44634849
28Toxoplasmosis_Homo sapiens_hsa051451.42611322
29TNF signaling pathway_Homo sapiens_hsa046681.40894689
30Dilated cardiomyopathy_Homo sapiens_hsa054141.40838869
31Salmonella infection_Homo sapiens_hsa051321.32188847
32Basal cell carcinoma_Homo sapiens_hsa052171.31016685
33Pancreatic cancer_Homo sapiens_hsa052121.24299538
34* Tight junction_Homo sapiens_hsa045301.21804128
35Melanoma_Homo sapiens_hsa052181.20626585
36Apoptosis_Homo sapiens_hsa042101.19063877
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15643708
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14131752
39Platelet activation_Homo sapiens_hsa046111.14102017
40Rap1 signaling pathway_Homo sapiens_hsa040151.13735156
41HTLV-I infection_Homo sapiens_hsa051661.13721471
42Prion diseases_Homo sapiens_hsa050201.11381199
43Pathways in cancer_Homo sapiens_hsa052001.10195403
44Prostate cancer_Homo sapiens_hsa052151.09863236
45Thyroid cancer_Homo sapiens_hsa052161.08573319
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08381969
47Glioma_Homo sapiens_hsa052141.07540736
48Osteoclast differentiation_Homo sapiens_hsa043801.03778175
49Galactose metabolism_Homo sapiens_hsa000521.03681545
50Hepatitis B_Homo sapiens_hsa051611.03258882
51Endometrial cancer_Homo sapiens_hsa052131.02670167
52Pentose phosphate pathway_Homo sapiens_hsa000300.98947831
53Protein digestion and absorption_Homo sapiens_hsa049740.98650717
54Lysosome_Homo sapiens_hsa041420.97195236
55Acute myeloid leukemia_Homo sapiens_hsa052210.95639703
56Vibrio cholerae infection_Homo sapiens_hsa051100.93912026
57Colorectal cancer_Homo sapiens_hsa052100.93686977
58VEGF signaling pathway_Homo sapiens_hsa043700.93343583
59mTOR signaling pathway_Homo sapiens_hsa041500.93223195
60Notch signaling pathway_Homo sapiens_hsa043300.91700457
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.91628444
62HIF-1 signaling pathway_Homo sapiens_hsa040660.91554445
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91232902
64Hedgehog signaling pathway_Homo sapiens_hsa043400.91102413
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89877410
66Renal cell carcinoma_Homo sapiens_hsa052110.88855026
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.87800420
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86334166
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.85468311
70* Viral carcinogenesis_Homo sapiens_hsa052030.83807061
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83321479
72Legionellosis_Homo sapiens_hsa051340.81652891
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80358569
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79941817
75Phagosome_Homo sapiens_hsa041450.79710195
76Antigen processing and presentation_Homo sapiens_hsa046120.79609782
77Pertussis_Homo sapiens_hsa051330.78914175
78Tuberculosis_Homo sapiens_hsa051520.77800441
79Measles_Homo sapiens_hsa051620.77561495
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76648490
81Non-small cell lung cancer_Homo sapiens_hsa052230.75030579
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73882818
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72210048
84GnRH signaling pathway_Homo sapiens_hsa049120.71551265
85Wnt signaling pathway_Homo sapiens_hsa043100.70338510
86N-Glycan biosynthesis_Homo sapiens_hsa005100.67620854
87Estrogen signaling pathway_Homo sapiens_hsa049150.66207455
88Prolactin signaling pathway_Homo sapiens_hsa049170.65869743
89Insulin signaling pathway_Homo sapiens_hsa049100.65586994
90Hematopoietic cell lineage_Homo sapiens_hsa046400.64727236
91Endocytosis_Homo sapiens_hsa041440.64672368
92Melanogenesis_Homo sapiens_hsa049160.64639604
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63952576
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.63893038
95FoxO signaling pathway_Homo sapiens_hsa040680.63256393
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.62599750
97Influenza A_Homo sapiens_hsa051640.61623988
98Axon guidance_Homo sapiens_hsa043600.61379061
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60812258
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60379445
101Chemokine signaling pathway_Homo sapiens_hsa040620.59956397
102MAPK signaling pathway_Homo sapiens_hsa040100.58852176
103ErbB signaling pathway_Homo sapiens_hsa040120.58681404
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55774576
105Fructose and mannose metabolism_Homo sapiens_hsa000510.55216229
106One carbon pool by folate_Homo sapiens_hsa006700.53946370
107Graft-versus-host disease_Homo sapiens_hsa053320.52501253
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.50351636
109Complement and coagulation cascades_Homo sapiens_hsa046100.50311197
110Herpes simplex infection_Homo sapiens_hsa051680.49416457
111Hepatitis C_Homo sapiens_hsa051600.48961077
112Ras signaling pathway_Homo sapiens_hsa040140.48433306
113Choline metabolism in cancer_Homo sapiens_hsa052310.48114506
114AMPK signaling pathway_Homo sapiens_hsa041520.48050167
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.48032900
116Gap junction_Homo sapiens_hsa045400.47896580
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47676873
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47405079
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.45699561
120T cell receptor signaling pathway_Homo sapiens_hsa046600.45491139
121Allograft rejection_Homo sapiens_hsa053300.45037351
122Inositol phosphate metabolism_Homo sapiens_hsa005620.44849569
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44665460
124Insulin resistance_Homo sapiens_hsa049310.44204247
125Dorso-ventral axis formation_Homo sapiens_hsa043200.42572795

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