ACTN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.49523837
2epithelial cell-cell adhesion (GO:0090136)4.39590382
3activation of Rac GTPase activity (GO:0032863)3.89358637
4regulation of hippo signaling (GO:0035330)3.89260812
5skin morphogenesis (GO:0043589)3.85279335
6cell adhesion mediated by integrin (GO:0033627)3.70528100
7cell-substrate junction assembly (GO:0007044)3.67653454
8protein retention in ER lumen (GO:0006621)3.64724956
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62354050
10wound healing, spreading of epidermal cells (GO:0035313)3.56083913
11positive regulation of SMAD protein import into nucleus (GO:0060391)3.55004717
12endodermal cell differentiation (GO:0035987)3.54863831
13regulation of glucose import in response to insulin stimulus (GO:2001273)3.54251144
14regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.53712251
15basement membrane organization (GO:0071711)3.46768295
16regulation of SMAD protein import into nucleus (GO:0060390)3.44477242
17semaphorin-plexin signaling pathway (GO:0071526)3.39078329
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.38817491
19barbed-end actin filament capping (GO:0051016)3.37428596
20desmosome organization (GO:0002934)3.35390768
21interferon-gamma secretion (GO:0072643)3.33730687
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.31479363
23positive regulation of endothelial cell apoptotic process (GO:2000353)3.30374781
24regulation of early endosome to late endosome transport (GO:2000641)3.30258849
25polarized epithelial cell differentiation (GO:0030859)3.27871686
26hippo signaling (GO:0035329)3.25877647
27hypotonic response (GO:0006971)3.20006082
28paraxial mesoderm development (GO:0048339)3.19668329
29chondrocyte proliferation (GO:0035988)3.19660729
30dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.17750567
31protein heterotrimerization (GO:0070208)3.15600331
32bundle of His cell to Purkinje myocyte communication (GO:0086069)3.15209720
33negative regulation of fatty acid transport (GO:2000192)3.11703975
34glomerular visceral epithelial cell development (GO:0072015)3.11282313
35adherens junction assembly (GO:0034333)3.09940498
36regulation of tight junction assembly (GO:2000810)3.06891500
37cell migration involved in sprouting angiogenesis (GO:0002042)3.06680281
38trophectodermal cell differentiation (GO:0001829)3.06506012
39heterochromatin organization (GO:0070828)3.05705497
40COPI coating of Golgi vesicle (GO:0048205)3.05292936
41Golgi transport vesicle coating (GO:0048200)3.05292936
42regulation of posttranscriptional gene silencing (GO:0060147)3.04880495
43regulation of gene silencing by miRNA (GO:0060964)3.04880495
44regulation of gene silencing by RNA (GO:0060966)3.04880495
45mesodermal cell differentiation (GO:0048333)3.01594660
46apoptotic process involved in morphogenesis (GO:0060561)2.99877782
47apoptotic cell clearance (GO:0043277)2.99654586
48vascular endothelial growth factor signaling pathway (GO:0038084)2.99038872
49actin filament depolymerization (GO:0030042)2.97261965
50branching involved in mammary gland duct morphogenesis (GO:0060444)2.97100363
51wound healing, spreading of cells (GO:0044319)2.96516766
52cytoskeletal anchoring at plasma membrane (GO:0007016)2.96265157
53positive regulation of Cdc42 GTPase activity (GO:0043089)2.94913031
54renal filtration (GO:0097205)2.94531471
55blood vessel endothelial cell migration (GO:0043534)2.93795923
56regulation of translational fidelity (GO:0006450)2.93571159
57atrioventricular valve morphogenesis (GO:0003181)2.93450751
58negative regulation of smooth muscle cell migration (GO:0014912)2.92286478
59negative regulation of cell size (GO:0045792)2.91336617
60glomerular basement membrane development (GO:0032836)2.87912264
61establishment of apical/basal cell polarity (GO:0035089)2.87510939
62embryonic process involved in female pregnancy (GO:0060136)2.80866247
63substrate adhesion-dependent cell spreading (GO:0034446)2.80564332
64negative regulation of chondrocyte differentiation (GO:0032331)2.79397755
65regulation of mammary gland epithelial cell proliferation (GO:0033599)2.78615748
66collagen fibril organization (GO:0030199)2.78260452
67folic acid-containing compound biosynthetic process (GO:0009396)2.77799240
68vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.74627331
69positive regulation of osteoblast proliferation (GO:0033690)2.74515922
70regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73599531
71endocardial cushion development (GO:0003197)2.71774715
72positive regulation of receptor recycling (GO:0001921)2.71574328
73glomerular epithelial cell development (GO:0072310)2.70835330
74endothelial cell morphogenesis (GO:0001886)2.70683893
75cell-substrate adherens junction assembly (GO:0007045)2.69322462
76focal adhesion assembly (GO:0048041)2.69322462
77maternal placenta development (GO:0001893)2.69185431
78membrane protein ectodomain proteolysis (GO:0006509)2.69079731
79positive regulation of epithelial to mesenchymal transition (GO:0010718)2.67044407
80low-density lipoprotein particle clearance (GO:0034383)2.66357508
81retina vasculature morphogenesis in camera-type eye (GO:0061299)2.63834653
82intestinal epithelial cell development (GO:0060576)2.63405684
83pentose-phosphate shunt (GO:0006098)2.60785847
84stress fiber assembly (GO:0043149)2.60753002
85glucose catabolic process (GO:0006007)2.59703578
86regulation of extracellular matrix disassembly (GO:0010715)2.59703279
87negative regulation of cell fate specification (GO:0009996)2.58529913
88membrane raft organization (GO:0031579)2.57858955
89substrate-dependent cell migration (GO:0006929)2.57685190
90proline biosynthetic process (GO:0006561)2.57077153
91regulation of translational termination (GO:0006449)2.56668413
92peptidyl-proline hydroxylation (GO:0019511)2.56025850
93mammary gland epithelial cell proliferation (GO:0033598)2.55899007
94branching involved in salivary gland morphogenesis (GO:0060445)2.55802210
95anterior/posterior axis specification, embryo (GO:0008595)2.55778648
96response to laminar fluid shear stress (GO:0034616)2.55289948
97positive regulation of p38MAPK cascade (GO:1900745)2.50477341
98Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.49922747
99endothelial cell chemotaxis (GO:0035767)2.49298719
100regulation of water loss via skin (GO:0033561)2.49291424
101labyrinthine layer blood vessel development (GO:0060716)2.47574434
102pinocytosis (GO:0006907)2.46232314
103positive regulation of extracellular matrix organization (GO:1903055)2.46026693
104protein targeting to plasma membrane (GO:0072661)2.45685434
105endothelial tube morphogenesis (GO:0061154)2.45345840
106morphogenesis of an endothelium (GO:0003159)2.45345840
107regulation of transforming growth factor beta1 production (GO:0032908)2.43585273
108gap junction assembly (GO:0016264)2.41986825
109DNA unwinding involved in DNA replication (GO:0006268)2.41513772
110endocytic recycling (GO:0032456)2.41495467
111vesicle coating (GO:0006901)2.41327023
112epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40788332
113regulation of cell fate specification (GO:0042659)2.40630067
114regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.40512507
115cellular response to interferon-alpha (GO:0035457)2.40232154
116* actin filament bundle organization (GO:0061572)2.39695123
117* actin filament bundle assembly (GO:0051017)2.39695123
118insulin-like growth factor receptor signaling pathway (GO:0048009)2.39155821
119positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.38753897
120cellular response to epidermal growth factor stimulus (GO:0071364)2.38572934
121positive regulation of blood vessel endothelial cell migration (GO:0043536)2.38524896
122muscle cell migration (GO:0014812)2.38419484
123positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.38387749
124* cell junction assembly (GO:0034329)2.37507880
125activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.37256197
126extracellular matrix disassembly (GO:0022617)2.36887498
127regulation of establishment of planar polarity (GO:0090175)2.36670257
128protein localization to endosome (GO:0036010)2.36578166
129regulation of integrin activation (GO:0033623)2.36462112
130cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.36431616
131regulation of mitotic spindle organization (GO:0060236)2.36161900
132cell-cell junction maintenance (GO:0045217)2.36122576
133mitotic nuclear envelope disassembly (GO:0007077)2.36118200
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.35008146
135positive regulation of nuclease activity (GO:0032075)2.34438170
136endoplasmic reticulum unfolded protein response (GO:0030968)2.34402296
137mitotic chromosome condensation (GO:0007076)2.34210204
138protein localization to kinetochore (GO:0034501)2.34034110
139positive regulation of histone deacetylation (GO:0031065)2.32306211
140protein hydroxylation (GO:0018126)2.32024607
141negative regulation of viral release from host cell (GO:1902187)2.31742664
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31449854
143cellular response to vitamin D (GO:0071305)2.31240659
144glucose 6-phosphate metabolic process (GO:0051156)2.31239556
145cellular response to vitamin (GO:0071295)2.30956878
146mRNA transcription (GO:0009299)2.30852348
147formation of translation preinitiation complex (GO:0001731)2.30536016
148regulation of cholesterol homeostasis (GO:2000188)2.29700387
149lung-associated mesenchyme development (GO:0060484)2.29436599
150type B pancreatic cell proliferation (GO:0044342)2.29179677
151regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.29156324
152collagen metabolic process (GO:0032963)2.28692005
153regulation of spindle organization (GO:0090224)2.28421465
154maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.27410875
155nuclear pore organization (GO:0006999)2.27138944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.60940345
2E2F7_22180533_ChIP-Seq_HELA_Human3.38068146
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99275944
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98337259
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.95995308
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.90006142
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.83908392
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.69963086
9CLOCK_20551151_ChIP-Seq_293T_Human2.53738054
10ZNF263_19887448_ChIP-Seq_K562_Human2.39522140
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14418001
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12599746
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10687449
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05745531
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03413388
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.03308098
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03288568
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02233037
19AR_21909140_ChIP-Seq_LNCAP_Human1.95186482
20* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94221412
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94109850
22ATF3_27146783_Chip-Seq_COLON_Human1.89616838
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.88696957
24MYC_22102868_ChIP-Seq_BL_Human1.85687379
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82450195
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78505810
27* RACK7_27058665_Chip-Seq_MCF-7_Human1.75431554
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74148467
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.72558705
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71913224
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.71420883
32* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61974083
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.59612945
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58588844
35* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58135355
36KDM2B_26808549_Chip-Seq_K562_Human1.57974969
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56430769
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54431626
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52144805
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50533464
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48628764
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47988847
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47988847
44TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47041473
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43439613
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41533710
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37345284
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35677079
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35018912
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.31837865
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31266357
52EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30659433
53* GATA6_25053715_ChIP-Seq_YYC3_Human1.30440990
54* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30221686
55VDR_21846776_ChIP-Seq_THP-1_Human1.29462333
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29304068
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29205722
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29205722
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29205722
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28577872
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28508823
62LXR_22292898_ChIP-Seq_THP-1_Human1.27982799
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27828585
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27757010
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24416814
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24117314
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23902998
68* KDM2B_26808549_Chip-Seq_DND41_Human1.23882878
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.22176168
70* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21805312
71* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21750085
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20670407
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18955739
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18787437
75TCF7_22412390_ChIP-Seq_EML_Mouse1.18080369
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16811167
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16120219
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15285926
79* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14961594
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14181297
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.13794075
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.13182398
83NCOR1_26117541_ChIP-Seq_K562_Human1.13125392
84* TP53_22127205_ChIP-Seq_IMR90_Human1.12040682
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.11673352
86* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10810696
87CREB1_26743006_Chip-Seq_LNCaP_Human1.10009215
88* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08070539
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08024719
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06804582
91* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05884391
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05839985
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05320617
94SMC4_20622854_ChIP-Seq_HELA_Human1.05229435
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.04790342
96P68_20966046_ChIP-Seq_HELA_Human1.04636378
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.03568042
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.03568042
99* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03561211
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02705836
101CHD1_26751641_Chip-Seq_LNCaP_Human1.02567477
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01832585
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.00494359
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.00470765
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99853989
106* GATA4_25053715_ChIP-Seq_YYC3_Human0.99440177
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98793945
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98784666
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98631803
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98441530
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97716356
112* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97605443
113* CDX2_20551321_ChIP-Seq_CACO-2_Human0.97351175
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96699824
115SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96448668
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.96424617
117* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96007432
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95289834
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94777926
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94509564
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94015917
122* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93923090
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92671176
124BRD4_25478319_ChIP-Seq_HGPS_Human0.92602197
125* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91236921
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90104108
127XRN2_22483619_ChIP-Seq_HELA_Human0.89943075
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89577798
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89118284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.23199833
2MP0010352_gastrointestinal_tract_polyps3.44518744
3MP0008438_abnormal_cutaneous_collagen3.38820652
4MP0010234_abnormal_vibrissa_follicle3.18606168
5MP0003566_abnormal_cell_adhesion3.07731133
6MP0005275_abnormal_skin_tensile2.86318892
7MP0004272_abnormal_basement_membrane2.61458096
8MP0005023_abnormal_wound_healing2.18350224
9MP0006054_spinal_hemorrhage2.05256274
10MP0005409_darkened_coat_color2.03550370
11MP0004858_abnormal_nervous_system1.96384790
12MP0005623_abnormal_meninges_morphology1.94281068
13MP0000537_abnormal_urethra_morphology1.90227310
14MP0005076_abnormal_cell_differentiation1.87793742
15MP0003279_aneurysm1.84064031
16MP0005451_abnormal_body_composition1.80289484
17MP0001849_ear_inflammation1.77767616
18MP0002796_impaired_skin_barrier1.74788663
19MP0010030_abnormal_orbit_morphology1.73866489
20MP0009053_abnormal_anal_canal1.67108694
21MP0003300_gastrointestinal_ulcer1.66456266
22MP0002060_abnormal_skin_morphology1.64752447
23MP0003191_abnormal_cellular_cholesterol1.59290312
24MP0001348_abnormal_lacrimal_gland1.55865052
25MP0003091_abnormal_cell_migration1.51660561
26MP0003941_abnormal_skin_development1.48952369
27MP0000678_abnormal_parathyroid_gland1.48751378
28MP0000579_abnormal_nail_morphology1.48476412
29MP0003950_abnormal_plasma_membrane1.47511227
30MP0004264_abnormal_extraembryonic_tissu1.46447393
31MP0005501_abnormal_skin_physiology1.46176996
32MP0001958_emphysema1.45405931
33MP0005058_abnormal_lysosome_morphology1.39292282
34MP0004957_abnormal_blastocyst_morpholog1.34768220
35MP0003453_abnormal_keratinocyte_physiol1.34521099
36MP0000733_abnormal_muscle_development1.34153528
37MP0002877_abnormal_melanocyte_morpholog1.33453134
38MP0000751_myopathy1.30581790
39MP0008260_abnormal_autophagy1.30059511
40MP0001730_embryonic_growth_arrest1.30011927
41MP0010368_abnormal_lymphatic_system1.28579426
42MP0005503_abnormal_tendon_morphology1.27719821
43MP0009384_cardiac_valve_regurgitation1.26563726
44MP0009840_abnormal_foam_cell1.26392797
45MP0003283_abnormal_digestive_organ1.24192059
46MP0003693_abnormal_embryo_hatching1.24123409
47MP0004233_abnormal_muscle_weight1.21503976
48MP0009780_abnormal_chondrocyte_physiolo1.21029680
49MP0004185_abnormal_adipocyte_glucose1.20310068
50MP0000566_synostosis1.18633580
51MP0002086_abnormal_extraembryonic_tissu1.15837363
52MP0001243_abnormal_dermal_layer1.14549287
53MP0003111_abnormal_nucleus_morphology1.10965028
54MP0010678_abnormal_skin_adnexa1.10240408
55MP0003984_embryonic_growth_retardation1.09854160
56MP0002088_abnormal_embryonic_growth/wei1.09694632
57MP0004197_abnormal_fetal_growth/weight/1.09000924
58MP0001672_abnormal_embryogenesis/_devel1.07135535
59MP0005380_embryogenesis_phenotype1.07135535
60MP0001216_abnormal_epidermal_layer1.06444547
61MP0009278_abnormal_bone_marrow1.05492687
62MP0005508_abnormal_skeleton_morphology1.05222623
63MP0000467_abnormal_esophagus_morphology1.03205751
64MP0000858_altered_metastatic_potential1.03111769
65MP0010307_abnormal_tumor_latency1.02408343
66MP0000750_abnormal_muscle_regeneration1.02406109
67MP0000003_abnormal_adipose_tissue1.02351761
68MP0000350_abnormal_cell_proliferation1.02213920
69MP0005621_abnormal_cell_physiology1.01089663
70MP0004084_abnormal_cardiac_muscle1.00836382
71MP0002084_abnormal_developmental_patter1.00598503
72MP0003115_abnormal_respiratory_system1.00157044
73MP0003878_abnormal_ear_physiology0.99193723
74MP0005377_hearing/vestibular/ear_phenot0.99193723
75MP0005257_abnormal_intraocular_pressure0.98941302
76MP0000767_abnormal_smooth_muscle0.98892363
77MP0001697_abnormal_embryo_size0.97209114
78MP0000462_abnormal_digestive_system0.97029615
79MP0002085_abnormal_embryonic_tissue0.96593330
80MP0001915_intracranial_hemorrhage0.96064709
81MP0000377_abnormal_hair_follicle0.95758219
82MP0002896_abnormal_bone_mineralization0.94465186
83MP0002925_abnormal_cardiovascular_devel0.94342655
84MP0006138_congestive_heart_failure0.94301246
85MP0004782_abnormal_surfactant_physiolog0.94263565
86MP0005360_urolithiasis0.92932118
87MP0005375_adipose_tissue_phenotype0.92452552
88MP0000477_abnormal_intestine_morphology0.91955926
89MP0000534_abnormal_ureter_morphology0.89974799
90MP0002098_abnormal_vibrissa_morphology0.88977123
91MP0002249_abnormal_larynx_morphology0.88730555
92MP0002254_reproductive_system_inflammat0.88119138
93MP0002080_prenatal_lethality0.86962789
94MP0005666_abnormal_adipose_tissue0.86623716
95MP0002111_abnormal_tail_morphology0.85315108
96MP0000490_abnormal_crypts_of0.85059040
97MP0001614_abnormal_blood_vessel0.84107823
98MP0000428_abnormal_craniofacial_morphol0.83079620
99MP0000762_abnormal_tongue_morphology0.82294358
100MP0002295_abnormal_pulmonary_circulatio0.82160486
101MP0003119_abnormal_digestive_system0.82100424
102MP0003077_abnormal_cell_cycle0.81522072
103MP0004947_skin_inflammation0.80788545
104MP0000627_abnormal_mammary_gland0.80450409
105MP0009931_abnormal_skin_appearance0.80315400
106MP0003045_fibrosis0.79635241
107MP0003385_abnormal_body_wall0.78819345
108MP0005367_renal/urinary_system_phenotyp0.77530343
109MP0000516_abnormal_urinary_system0.77530343
110MP0003448_altered_tumor_morphology0.76602069
111MP0010630_abnormal_cardiac_muscle0.76497849
112MP0002282_abnormal_trachea_morphology0.76490768
113MP0003567_abnormal_fetal_cardiomyocyte0.75866415
114MP0000013_abnormal_adipose_tissue0.74864125
115MP0002128_abnormal_blood_circulation0.73870196
116MP0002089_abnormal_postnatal_growth/wei0.73459282
117MP0000383_abnormal_hair_follicle0.73434694
118MP0003942_abnormal_urinary_system0.72755357
119MP0010771_integument_phenotype0.71951885
120MP0003329_amyloid_beta_deposits0.71836998
121MP0000759_abnormal_skeletal_muscle0.70446843
122MP0008007_abnormal_cellular_replicative0.69996891
123MP0004087_abnormal_muscle_fiber0.68694893
124MP0002998_abnormal_bone_remodeling0.66951285
125MP0000432_abnormal_head_morphology0.64475054
126MP0001542_abnormal_bone_strength0.63457512
127MP0005165_increased_susceptibility_to0.62996833
128MP0005197_abnormal_uvea_morphology0.62424944
129MP0003828_pulmonary_edema0.62075805
130MP0005164_abnormal_response_to0.61455501
131MP0001299_abnormal_eye_distance/0.61144509

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.32963018
2Premature rupture of membranes (HP:0001788)5.22270345
3Atrophic scars (HP:0001075)4.18843375
4Shallow orbits (HP:0000586)3.93711066
5Right ventricular cardiomyopathy (HP:0011663)3.86583940
6Ankle contracture (HP:0006466)3.65572750
7Cerebral aneurysm (HP:0004944)3.59737735
8Broad face (HP:0000283)3.47587793
9Distal lower limb amyotrophy (HP:0008944)3.31260396
10Hyperacusis (HP:0010780)3.24506574
11Aortic dissection (HP:0002647)3.11958582
12Increased connective tissue (HP:0009025)3.03900206
13Cervical subluxation (HP:0003308)3.00818332
14Fragile skin (HP:0001030)3.00176541
15Aortic aneurysm (HP:0004942)2.98194229
16Arterial tortuosity (HP:0005116)2.89676289
17Peritonitis (HP:0002586)2.79588021
18Vascular tortuosity (HP:0004948)2.79230175
19Milia (HP:0001056)2.75244145
20Genu recurvatum (HP:0002816)2.64160434
21Dilatation of the ascending aorta (HP:0005111)2.62023191
22Distal lower limb muscle weakness (HP:0009053)2.60898474
23Flat acetabular roof (HP:0003180)2.49138389
24Broad metatarsal (HP:0001783)2.45730208
25Mitral valve prolapse (HP:0001634)2.43712018
26Aneurysm (HP:0002617)2.43204699
27Selective tooth agenesis (HP:0001592)2.42273092
28Difficulty climbing stairs (HP:0003551)2.38704540
29Bladder diverticulum (HP:0000015)2.36959253
30Distal upper limb amyotrophy (HP:0007149)2.35698154
31Upper limb amyotrophy (HP:0009129)2.35698154
32Natal tooth (HP:0000695)2.34848789
33Lower limb amyotrophy (HP:0007210)2.34499040
34Ulnar bowing (HP:0003031)2.34385751
35Blue sclerae (HP:0000592)2.33736438
36Disproportionate tall stature (HP:0001519)2.27721864
37Mitral regurgitation (HP:0001653)2.26262392
38Neonatal short-limb short stature (HP:0008921)2.25366022
39Spinal rigidity (HP:0003306)2.21777032
40Soft skin (HP:0000977)2.20480197
41Advanced eruption of teeth (HP:0006288)2.18560265
42Abnormality of the calcaneus (HP:0008364)2.17566443
43Abnormality of the distal phalanges of the toes (HP:0010182)2.12427198
44Abnormality of oral frenula (HP:0000190)2.11707977
45Abnormality of the acetabulum (HP:0003170)2.11579264
46Osteolytic defects of the hand bones (HP:0009699)2.11081526
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.11081526
48Hand muscle atrophy (HP:0009130)2.10623821
49Trismus (HP:0000211)2.10159615
50Wormian bones (HP:0002645)2.09730192
51Abnormal vertebral ossification (HP:0100569)2.09294388
52Mesangial abnormality (HP:0001966)2.08939270
53Pili torti (HP:0003777)2.07071206
54Thin bony cortex (HP:0002753)2.06907570
55Radial bowing (HP:0002986)2.06710714
56Ileus (HP:0002595)2.06294049
57Obstructive sleep apnea (HP:0002870)2.04688452
58Wrist flexion contracture (HP:0001239)2.03409292
59Fragile nails (HP:0001808)1.99832931
60Short nail (HP:0001799)1.99489863
61Ankyloglossia (HP:0010296)1.99246391
62Insomnia (HP:0100785)1.98645115
63Pterygium (HP:0001059)1.97283934
64Increased density of long bones (HP:0006392)1.95145925
65Mildly elevated creatine phosphokinase (HP:0008180)1.94350969
66Spondylolisthesis (HP:0003302)1.92488132
67Abnormality of carpal bone ossification (HP:0006257)1.91876189
68Spinal cord compression (HP:0002176)1.91674679
69Deviation of the thumb (HP:0009603)1.91329097
70Bowed forearm bones (HP:0003956)1.89595891
71Bowing of the arm (HP:0006488)1.89595891
72Nonimmune hydrops fetalis (HP:0001790)1.89108880
73Long palpebral fissure (HP:0000637)1.88654030
74Onycholysis (HP:0001806)1.88019680
75Rectal prolapse (HP:0002035)1.87244123
76Increased mean platelet volume (HP:0011877)1.86163843
77Acanthosis nigricans (HP:0000956)1.84615478
78Fused cervical vertebrae (HP:0002949)1.84051521
79Tibial bowing (HP:0002982)1.82880157
80Stridor (HP:0010307)1.82603262
81Breech presentation (HP:0001623)1.81981892
82Hemorrhage of the eye (HP:0011885)1.81493265
83Abnormality of the peritoneum (HP:0002585)1.81433362
84Deviation of the hallux (HP:0010051)1.80788044
85Joint laxity (HP:0001388)1.80730713
86Abnormality of dentin (HP:0010299)1.80678952
87Esophageal varix (HP:0002040)1.79893816
88Metaphyseal cupping (HP:0003021)1.79691047
89Vertebral clefting (HP:0008428)1.79373093
90Abnormality of the distal phalanx of the thumb (HP:0009617)1.77987145
91Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77678152
92Vertebral hypoplasia (HP:0008417)1.77678152
93Asymmetry of the thorax (HP:0001555)1.77633577
94Back pain (HP:0003418)1.76870093
95Alopecia of scalp (HP:0002293)1.76554553
96Short humerus (HP:0005792)1.76408634
97Generalized amyotrophy (HP:0003700)1.76399116
98Bowel diverticulosis (HP:0005222)1.76194115
99Cardiovascular calcification (HP:0011915)1.75110815
100Vertebral compression fractures (HP:0002953)1.73611586
101Increased variability in muscle fiber diameter (HP:0003557)1.73553735
102Type 1 muscle fiber predominance (HP:0003803)1.73031149
103Scapular winging (HP:0003691)1.72043995
104Ependymoma (HP:0002888)1.71762217
105Persistence of primary teeth (HP:0006335)1.71748197
106Reduced subcutaneous adipose tissue (HP:0003758)1.71326771
107Abnormal delivery (HP:0001787)1.70541510
108Achilles tendon contracture (HP:0001771)1.70535899
109Woolly hair (HP:0002224)1.70378121
110Hallux valgus (HP:0001822)1.70239505
111Biconcave vertebral bodies (HP:0004586)1.67972098
112Nail dystrophy (HP:0008404)1.67783974
113Chondrocalcinosis (HP:0000934)1.67749618
114Elbow flexion contracture (HP:0002987)1.67634035
115Interstitial pulmonary disease (HP:0006530)1.67605534
116Biliary tract neoplasm (HP:0100574)1.67331178
117Aortic regurgitation (HP:0001659)1.67298869
118Platyspondyly (HP:0000926)1.66108607
119Hyperextensible skin (HP:0000974)1.65787331
120Bronchomalacia (HP:0002780)1.65607036
121Mitral stenosis (HP:0001718)1.65527955
122Aplasia/hypoplasia of the humerus (HP:0006507)1.64787828
123Spinal cord lesions (HP:0100561)1.64534985
124Syringomyelia (HP:0003396)1.64534985
125Camptodactyly of toe (HP:0001836)1.63767521
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62596933
127Short 4th metacarpal (HP:0010044)1.62596933
128Muscle fiber splitting (HP:0003555)1.62245150
129Renal duplication (HP:0000075)1.59792097
130Long toe (HP:0010511)1.59680433
131Abnormality of skeletal muscle fiber size (HP:0012084)1.58723145
132Hyperparathyroidism (HP:0000843)1.58201161
133Lymphangioma (HP:0100764)1.58036214
134Proximal placement of thumb (HP:0009623)1.57636994
135Dislocated radial head (HP:0003083)1.57075004
136Coxa vara (HP:0002812)1.56686932
137Neonatal death (HP:0003811)1.56665664
138Myocardial infarction (HP:0001658)1.56303945
139Abnormal ossification of hand bones (HP:0005921)1.56274369
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.56270263
141Abnormality of the Achilles tendon (HP:0005109)1.55665502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.92503560
2TRIB33.74588111
3PKN22.86335263
4SMG12.80617953
5IRAK32.64861124
6TTN2.59811770
7EEF2K2.33473576
8ERN12.32938747
9LATS12.05942623
10RIPK11.99352479
11PAK41.89244543
12DDR21.89090295
13CDK121.88656022
14SIK11.83779202
15PTK61.83080627
16PDGFRA1.82337255
17STK101.82148356
18MAP3K101.80141949
19PRPF4B1.68527769
20LRRK21.67529067
21PTK21.65604191
22RPS6KB21.62908247
23TESK11.61127359
24EPHB21.58686373
25MET1.54982906
26KDR1.54147204
27BMX1.52485302
28PAK21.51721885
29FER1.50512965
30LATS21.46779932
31TESK21.43001242
32NTRK11.42320899
33NEK11.38112577
34EPHB11.37045976
35MAP3K81.34609465
36MAP3K31.26452831
37RPS6KA41.23152695
38MTOR1.17363644
39NEK21.15280027
40BUB11.14230406
41MAP2K21.07564884
42TTK1.07421129
43CDK61.01917285
44FGFR41.01203727
45PRKD20.99256231
46MST1R0.98901843
47SCYL20.98360189
48ERBB40.97428574
49MAPKAPK30.97394803
50STK30.96888211
51WEE10.95987520
52CDC42BPA0.95488944
53TGFBR10.94809982
54FGFR10.94027092
55TRPM70.92340802
56TAOK10.86764847
57MST40.85762517
58STK380.82817200
59MAP3K60.82626955
60TGFBR20.81887040
61NME20.81705160
62RPS6KA20.81379906
63MAP2K30.79273325
64STK38L0.78467353
65DMPK0.77567897
66ARAF0.77539294
67PRKG20.74609923
68TAOK20.74347816
69FLT30.74185049
70ALK0.73398531
71PIM20.73114177
72EPHA30.72288376
73CDK40.71675640
74MAP3K110.71450744
75PAK10.71187312
76MAP2K10.70517649
77AURKB0.70327989
78CAMK1D0.68688073
79MOS0.68025741
80CDK80.67403999
81LIMK10.67097929
82CDK70.65641516
83PDPK10.64656666
84PAK30.63856232
85PDGFRB0.62631873
86ILK0.62393317
87ICK0.62209614
88PRKCI0.62033161
89PRKD30.61590181
90CDK90.58544553
91TIE10.57455664
92MAP3K10.56696557
93MAP3K130.55262230
94PASK0.54626883
95MARK20.54360404
96CDC70.53712111
97DYRK1B0.52317711
98MELK0.49499188
99PIK3CA0.48324491
100MAPK110.47821289
101MYLK0.47785942
102TSSK60.47462087
103ROCK20.47118329
104ERBB20.42899230
105MAP3K20.42509990
106FRK0.40862612
107IRAK20.40534315
108PTK2B0.40194497
109WNK40.39628218
110MAPKAPK20.39482875
111HIPK20.39109960
112BRAF0.38516030
113RPS6KL10.38028680
114RPS6KC10.38028680
115MATK0.37506438
116RET0.37454122
117LMTK20.36965350
118NEK90.36924974
119AURKA0.35616224
120MAP3K90.35227480
121AKT20.34715661
122PLK10.34423915
123ROCK10.31862339
124PRKD10.31786373
125CHEK10.31182676
126KSR20.31153679
127DAPK30.30871234
128GSK3A0.30458038
129ABL20.29630112
130INSR0.29267600
131TBK10.29245248
132ZAP700.28032473
133CAMK2G0.27239232
134SIK30.26580982

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.01992612
2Bladder cancer_Homo sapiens_hsa052192.45491732
3Small cell lung cancer_Homo sapiens_hsa052222.25963312
4* Focal adhesion_Homo sapiens_hsa045102.19367668
5* Adherens junction_Homo sapiens_hsa045202.16361013
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.11833802
7Proteoglycans in cancer_Homo sapiens_hsa052051.97384136
8Hippo signaling pathway_Homo sapiens_hsa043901.90886819
9Protein digestion and absorption_Homo sapiens_hsa049741.79071526
10Other glycan degradation_Homo sapiens_hsa005111.71692010
11MicroRNAs in cancer_Homo sapiens_hsa052061.65735959
12p53 signaling pathway_Homo sapiens_hsa041151.63916653
13* Tight junction_Homo sapiens_hsa045301.60419211
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60128425
15One carbon pool by folate_Homo sapiens_hsa006701.55735943
16* Leukocyte transendothelial migration_Homo sapiens_hsa046701.55576852
17Chronic myeloid leukemia_Homo sapiens_hsa052201.53097679
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53023188
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47044407
20* Amoebiasis_Homo sapiens_hsa051461.44461074
21Renin-angiotensin system_Homo sapiens_hsa046141.37473512
22Basal cell carcinoma_Homo sapiens_hsa052171.37239591
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36924510
24TGF-beta signaling pathway_Homo sapiens_hsa043501.35308648
25Thyroid cancer_Homo sapiens_hsa052161.32732141
26Fat digestion and absorption_Homo sapiens_hsa049751.32238747
27* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29648102
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.28239314
29Cell cycle_Homo sapiens_hsa041101.24770337
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22835645
31Prion diseases_Homo sapiens_hsa050201.20352600
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.19440506
33Shigellosis_Homo sapiens_hsa051311.17776325
34RNA transport_Homo sapiens_hsa030131.16967996
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16595807
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13666197
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10492648
38* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08673902
39ErbB signaling pathway_Homo sapiens_hsa040121.07821272
40Selenocompound metabolism_Homo sapiens_hsa004501.07092163
41Notch signaling pathway_Homo sapiens_hsa043301.06307263
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.02735687
43Insulin signaling pathway_Homo sapiens_hsa049101.01864434
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01180338
45Pancreatic cancer_Homo sapiens_hsa052121.00303288
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00259548
47HTLV-I infection_Homo sapiens_hsa051660.99307075
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.98851634
49HIF-1 signaling pathway_Homo sapiens_hsa040660.97859255
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96712858
51DNA replication_Homo sapiens_hsa030300.95635199
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94813813
53Lysine degradation_Homo sapiens_hsa003100.94664077
54Viral myocarditis_Homo sapiens_hsa054160.94615618
55Caffeine metabolism_Homo sapiens_hsa002320.94349485
56Pathways in cancer_Homo sapiens_hsa052000.94098314
57Toxoplasmosis_Homo sapiens_hsa051450.92227665
58Galactose metabolism_Homo sapiens_hsa000520.92145382
59Prostate cancer_Homo sapiens_hsa052150.91656834
60Endometrial cancer_Homo sapiens_hsa052130.88412272
61Vibrio cholerae infection_Homo sapiens_hsa051100.88119795
62Apoptosis_Homo sapiens_hsa042100.87673455
63Estrogen signaling pathway_Homo sapiens_hsa049150.87299803
64Hedgehog signaling pathway_Homo sapiens_hsa043400.87028047
65Biosynthesis of amino acids_Homo sapiens_hsa012300.86971298
66GnRH signaling pathway_Homo sapiens_hsa049120.81860420
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80824408
68Renal cell carcinoma_Homo sapiens_hsa052110.80259654
69Acute myeloid leukemia_Homo sapiens_hsa052210.79743008
70N-Glycan biosynthesis_Homo sapiens_hsa005100.79333164
71Dilated cardiomyopathy_Homo sapiens_hsa054140.78514246
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78239105
73Carbon metabolism_Homo sapiens_hsa012000.77777824
74Pentose phosphate pathway_Homo sapiens_hsa000300.77478870
75Melanoma_Homo sapiens_hsa052180.77279541
76mTOR signaling pathway_Homo sapiens_hsa041500.76677410
77* Viral carcinogenesis_Homo sapiens_hsa052030.76022882
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.75735313
79Glutathione metabolism_Homo sapiens_hsa004800.73821776
80Insulin resistance_Homo sapiens_hsa049310.73212649
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72440008
82VEGF signaling pathway_Homo sapiens_hsa043700.71933617
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71696654
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71571983
85Inositol phosphate metabolism_Homo sapiens_hsa005620.70389683
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69494900
87Mineral absorption_Homo sapiens_hsa049780.69327339
88Axon guidance_Homo sapiens_hsa043600.69102714
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68363307
90Choline metabolism in cancer_Homo sapiens_hsa052310.67831687
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67598509
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66614292
93Spliceosome_Homo sapiens_hsa030400.64919986
94Vitamin digestion and absorption_Homo sapiens_hsa049770.64052507
95Colorectal cancer_Homo sapiens_hsa052100.64000259
96Rap1 signaling pathway_Homo sapiens_hsa040150.63208732
97Fructose and mannose metabolism_Homo sapiens_hsa000510.63144618
98AMPK signaling pathway_Homo sapiens_hsa041520.62276740
99Antigen processing and presentation_Homo sapiens_hsa046120.62197743
100PPAR signaling pathway_Homo sapiens_hsa033200.62161960
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61739650
102Melanogenesis_Homo sapiens_hsa049160.60175019
103Salmonella infection_Homo sapiens_hsa051320.59857397
104Prolactin signaling pathway_Homo sapiens_hsa049170.58765156
105Glucagon signaling pathway_Homo sapiens_hsa049220.58285828
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58253392
107Vitamin B6 metabolism_Homo sapiens_hsa007500.58093156
108Gap junction_Homo sapiens_hsa045400.57418971
109Platelet activation_Homo sapiens_hsa046110.57299905
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57206403
111Thyroid hormone synthesis_Homo sapiens_hsa049180.56710014
112Non-small cell lung cancer_Homo sapiens_hsa052230.55368971
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.54471807
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53876626
115Malaria_Homo sapiens_hsa051440.52447188
116Phenylalanine metabolism_Homo sapiens_hsa003600.51873957
117Hepatitis B_Homo sapiens_hsa051610.51683127
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51148519
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50056529
120Folate biosynthesis_Homo sapiens_hsa007900.49752456
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49313232
122Mismatch repair_Homo sapiens_hsa034300.49286686
123Endocytosis_Homo sapiens_hsa041440.48450532
124Bile secretion_Homo sapiens_hsa049760.46505351
125TNF signaling pathway_Homo sapiens_hsa046680.46217118
126Base excision repair_Homo sapiens_hsa034100.46175195
127Glioma_Homo sapiens_hsa052140.43904315
128Legionellosis_Homo sapiens_hsa051340.43498187
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42383732
130Fatty acid degradation_Homo sapiens_hsa000710.41794955
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.41598444
132Hepatitis C_Homo sapiens_hsa051600.41024035

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »