ACTN4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)5.81399102
2protein polyglutamylation (GO:0018095)5.66445714
3viral mRNA export from host cell nucleus (GO:0046784)5.53610581
4regulation of DNA endoreduplication (GO:0032875)5.53419012
5regulation of skeletal muscle contraction (GO:0014819)5.24416789
6receptor recycling (GO:0001881)5.20461702
7negative regulation of muscle hypertrophy (GO:0014741)5.05710014
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.90759029
9response to gravity (GO:0009629)4.85939906
10photoreceptor cell differentiation (GO:0046530)4.82418146
11eye photoreceptor cell differentiation (GO:0001754)4.82418146
12interferon-gamma production (GO:0032609)4.72805566
13DNA damage response, signal transduction resulting in transcription (GO:0042772)4.47683417
14regulation of RIG-I signaling pathway (GO:0039535)4.44333424
15pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)4.41878780
16UMP biosynthetic process (GO:0006222)4.41878780
17pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)4.41878780
18UMP metabolic process (GO:0046049)4.41878780
19hemoglobin metabolic process (GO:0020027)4.41385046
20detection of light stimulus involved in visual perception (GO:0050908)4.38867294
21detection of light stimulus involved in sensory perception (GO:0050962)4.38867294
22cellular response to exogenous dsRNA (GO:0071360)4.37069996
23regulation of response to osmotic stress (GO:0047484)4.31228722
24dosage compensation (GO:0007549)4.23447556
25negative regulation of calcium ion transport into cytosol (GO:0010523)4.23230288
26ribosomal small subunit assembly (GO:0000028)4.16647576
27response to testosterone (GO:0033574)4.10504808
28response to electrical stimulus (GO:0051602)3.95768625
29embryonic process involved in female pregnancy (GO:0060136)3.88421116
30negative regulation of skeletal muscle tissue development (GO:0048642)3.86151893
31cellular hyperosmotic response (GO:0071474)3.85841680
32regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.82735942
33lymphoid progenitor cell differentiation (GO:0002320)3.79917137
34regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.79202139
35positive regulation of immune response to tumor cell (GO:0002839)3.76075684
36regulation of immune response to tumor cell (GO:0002837)3.76075684
37regulation of response to tumor cell (GO:0002834)3.76075684
38positive regulation of response to tumor cell (GO:0002836)3.76075684
39response to xenobiotic stimulus (GO:0009410)3.75765600
40positive regulation of interferon-beta production (GO:0032728)3.74029559
41negative regulation of viral transcription (GO:0032897)3.67748823
42pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.59188083
43regulation of growth hormone secretion (GO:0060123)3.49550553
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.46600978
45striated muscle atrophy (GO:0014891)3.45447995
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.45145232
47dicarboxylic acid biosynthetic process (GO:0043650)3.44111319
48mitochondrial RNA metabolic process (GO:0000959)3.43681103
49regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.42863939
50negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.38972226
51skeletal muscle adaptation (GO:0043501)3.38762313
52dicarboxylic acid catabolic process (GO:0043649)3.38739785
53erythrocyte maturation (GO:0043249)3.34229560
54termination of RNA polymerase III transcription (GO:0006386)3.30292437
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.30292437
56pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.30200456
57pyrimidine nucleoside salvage (GO:0043097)3.28191789
58pyrimidine-containing compound salvage (GO:0008655)3.28191789
59ribosome biogenesis (GO:0042254)3.28002162
60cellular response to dsRNA (GO:0071359)3.26777945
61cellular potassium ion homeostasis (GO:0030007)3.24396575
62muscle atrophy (GO:0014889)3.22242407
63regulation of germinal center formation (GO:0002634)3.14935719
64negative regulation of JAK-STAT cascade (GO:0046426)3.06141064
65positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.04377062
66COPII vesicle coating (GO:0048208)3.01152802
67energy homeostasis (GO:0097009)3.00594990
68glandular epithelial cell differentiation (GO:0002067)2.99009027
69regulation of gonadotropin secretion (GO:0032276)2.97320263
70striatum development (GO:0021756)2.96211353
71response to muscle activity (GO:0014850)2.95040430
72interferon-gamma secretion (GO:0072643)2.94820010
73Golgi transport vesicle coating (GO:0048200)2.94560589
74COPI coating of Golgi vesicle (GO:0048205)2.94560589
75positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.92391665
76dentate gyrus development (GO:0021542)2.89985599
77membrane repolarization during action potential (GO:0086011)2.88445831
78mature B cell differentiation (GO:0002335)2.84455214
79nucleotide salvage (GO:0043173)2.83217305
80positive regulation of natural killer cell mediated immunity (GO:0002717)2.80950665
81negative regulation of viral release from host cell (GO:1902187)2.79931750
82response to copper ion (GO:0046688)2.78942071
83magnesium ion transport (GO:0015693)2.75803831
84positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.75154651
85generation of neurons (GO:0048699)2.75089884
86retina homeostasis (GO:0001895)2.74587508
87positive regulation of mRNA catabolic process (GO:0061014)2.73135553
88positive regulation of Notch signaling pathway (GO:0045747)2.70678056
89pseudouridine synthesis (GO:0001522)2.70483264
90mature B cell differentiation involved in immune response (GO:0002313)2.70139194
91myoblast differentiation (GO:0045445)2.67472993
92negative regulation of muscle tissue development (GO:1901862)2.63976105
93pyrimidine-containing compound transmembrane transport (GO:0072531)2.61200272
94definitive hemopoiesis (GO:0060216)2.61128053
95GDP-mannose metabolic process (GO:0019673)2.59864755
96DNA ligation (GO:0006266)2.59541515
97positive regulation of response to cytokine stimulus (GO:0060760)2.59387389
98negative regulation by host of viral transcription (GO:0043922)2.58707729
99positive regulation of transcription regulatory region DNA binding (GO:2000679)2.57510020
100negative regulation of striated muscle tissue development (GO:0045843)2.56329674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human8.21289774
2ELF1_17652178_ChIP-ChIP_JURKAT_Human5.53077437
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.90103318
4NOTCH1_21737748_ChIP-Seq_TLL_Human4.16223076
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.55370127
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.73740110
7CIITA_25753668_ChIP-Seq_RAJI_Human2.72533877
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59883204
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.56017085
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.53297084
11MYC_22102868_ChIP-Seq_BL_Human2.46530773
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42560915
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27062524
14E2F7_22180533_ChIP-Seq_HELA_Human2.24203038
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21671246
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18524370
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17221480
18BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.17129419
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.11368778
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.10422441
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.92032216
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88918600
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.87024899
24XRN2_22483619_ChIP-Seq_HELA_Human1.85538691
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.72411678
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64400497
27FOXP3_21729870_ChIP-Seq_TREG_Human1.63881172
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.63709030
29PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.60975185
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58018414
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56620958
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49681926
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43534672
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42124664
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41110360
36STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.38883661
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37654929
38TTF2_22483619_ChIP-Seq_HELA_Human1.37320667
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36509194
40EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.35428104
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.30986860
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27530091
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26502938
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25935695
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24785736
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.24677179
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24294270
48MAF_26560356_Chip-Seq_TH1_Human1.24224986
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.23946602
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.21556570
51MYB_26560356_Chip-Seq_TH1_Human1.21210579
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.21060643
53P68_20966046_ChIP-Seq_HELA_Human1.20647510
54MYB_26560356_Chip-Seq_TH2_Human1.20550865
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20019845
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.18154063
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18152968
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.16422047
59VDR_22108803_ChIP-Seq_LS180_Human1.15790618
60TP53_22127205_ChIP-Seq_IMR90_Human1.15338485
61SPI1_20517297_ChIP-Seq_HL60_Human1.14882758
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14728028
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14191248
64RUNX_20019798_ChIP-Seq_JUKART_Human1.13484732
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.13237807
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.12807453
67UTX_26944678_Chip-Seq_JUKART_Human1.11010553
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10955587
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09770948
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09218174
71KDM5A_27292631_Chip-Seq_BREAST_Human1.08837442
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.08361036
73SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.07624497
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06404754
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05447941
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04450325
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01831624
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.00210168
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00188470
80FOXP1_21924763_ChIP-Seq_HESCs_Human0.99775351
81TET1_21451524_ChIP-Seq_MESCs_Mouse0.97423563
82STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97329368
83TAF15_26573619_Chip-Seq_HEK293_Human0.96046839
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94178808
85GABP_19822575_ChIP-Seq_HepG2_Human0.94134031
86CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92427562
87CTCF_20526341_ChIP-Seq_ESCs_Human0.91434986
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90115402
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89446501
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88877289
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88846736
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88652857
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.88184292
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.88129445
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86446219
96BCOR_27268052_Chip-Seq_Bcells_Human0.86281870
97P300_27268052_Chip-Seq_Bcells_Human0.84568464
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84138345
99NANOG_20526341_ChIP-Seq_ESCs_Human0.80119401
100GATA1_22025678_ChIP-Seq_K562_Human0.79979064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis4.20542328
2MP0005409_darkened_coat_color3.28593607
3MP0005671_abnormal_response_to3.12288055
4MP0009379_abnormal_foot_pigmentation2.90119736
5MP0002396_abnormal_hematopoietic_system2.76045544
6MP0003646_muscle_fatigue2.70289431
7MP0002163_abnormal_gland_morphology2.59461165
8MP0003300_gastrointestinal_ulcer2.41923138
9MP0001188_hyperpigmentation2.38658490
10MP0002089_abnormal_postnatal_growth/wei2.35722150
11MP0003283_abnormal_digestive_organ2.34552871
12MP0000733_abnormal_muscle_development2.21686314
13MP0008058_abnormal_DNA_repair2.09937902
14MP0010094_abnormal_chromosome_stability2.04704425
15MP0004134_abnormal_chest_morphology1.98992396
16MP0002822_catalepsy1.96690911
17MP0009780_abnormal_chondrocyte_physiolo1.95610282
18MP0001529_abnormal_vocalization1.91135219
19MP0004145_abnormal_muscle_electrophysio1.87007404
20MP0004264_abnormal_extraembryonic_tissu1.78515772
21MP0002160_abnormal_reproductive_system1.75164287
22MP0009250_abnormal_appendicular_skeleto1.73760134
23MP0004133_heterotaxia1.70031723
24MP0004036_abnormal_muscle_relaxation1.59801153
25MP0000613_abnormal_salivary_gland1.55418578
26MP0010368_abnormal_lymphatic_system1.54277828
27MP0004885_abnormal_endolymph1.54132353
28MP0003806_abnormal_nucleotide_metabolis1.53901908
29MP0005257_abnormal_intraocular_pressure1.46275106
30MP0005623_abnormal_meninges_morphology1.45402134
31MP0001542_abnormal_bone_strength1.45018760
32MP0003866_abnormal_defecation1.40973345
33MP0000462_abnormal_digestive_system1.40865896
34MP0000490_abnormal_crypts_of1.38702643
35MP0000049_abnormal_middle_ear1.36790721
36MP0003943_abnormal_hepatobiliary_system1.36469023
37MP0000747_muscle_weakness1.29602870
38MP0009765_abnormal_xenobiotic_induced1.27900474
39MP0005379_endocrine/exocrine_gland_phen1.26283346
40MP0010155_abnormal_intestine_physiology1.25310292
41MP0004197_abnormal_fetal_growth/weight/1.21338786
42MP0005389_reproductive_system_phenotype1.20659454
43MP0001730_embryonic_growth_arrest1.19872253
44MP0005174_abnormal_tail_pigmentation1.19732794
45MP0000537_abnormal_urethra_morphology1.19194792
46MP0000759_abnormal_skeletal_muscle1.18936062
47MP0005551_abnormal_eye_electrophysiolog1.17832185
48MP0004808_abnormal_hematopoietic_stem1.16495301
49MP0000685_abnormal_immune_system1.15815079
50MP0001348_abnormal_lacrimal_gland1.14470255
51MP0009053_abnormal_anal_canal1.12491285
52MP0003315_abnormal_perineum_morphology1.12221464
53MP0003763_abnormal_thymus_physiology1.12185651
54MP0008789_abnormal_olfactory_epithelium1.09367348
55MP0004233_abnormal_muscle_weight1.05335471
56MP0002269_muscular_atrophy1.05314478
57MP0000678_abnormal_parathyroid_gland1.04939020
58MP0003937_abnormal_limbs/digits/tail_de1.02318216
59MP0001502_abnormal_circadian_rhythm1.00503996
60MP0000749_muscle_degeneration1.00391674
61MP0000762_abnormal_tongue_morphology0.99900525
62MP0001243_abnormal_dermal_layer0.99354613
63MP0004087_abnormal_muscle_fiber0.99274527
64MP0003786_premature_aging0.98576388
65MP0000467_abnormal_esophagus_morphology0.97733602
66MP0000477_abnormal_intestine_morphology0.97364565
67MP0002102_abnormal_ear_morphology0.97062524
68MP0002084_abnormal_developmental_patter0.95223204
69MP0000647_abnormal_sebaceous_gland0.89916414
70MP0003115_abnormal_respiratory_system0.89548350
71MP0002638_abnormal_pupillary_reflex0.87773826
72MP0005083_abnormal_biliary_tract0.87280023
73MP0000703_abnormal_thymus_morphology0.86855694
74MP0003948_abnormal_gas_homeostasis0.86270333
75MP0001984_abnormal_olfaction0.85823225
76MP0010352_gastrointestinal_tract_polyps0.84700330
77MP0004147_increased_porphyrin_level0.83675480
78MP0002086_abnormal_extraembryonic_tissu0.80808657
79MP0001849_ear_inflammation0.76527795
80MP0003045_fibrosis0.74901066
81MP0002095_abnormal_skin_pigmentation0.74643230
82MP0002106_abnormal_muscle_physiology0.73325202
83MP0000013_abnormal_adipose_tissue0.73220686
84MP0005451_abnormal_body_composition0.72871102
85MP0000465_gastrointestinal_hemorrhage0.71684695
86MP0008875_abnormal_xenobiotic_pharmacok0.71579194
87MP0008932_abnormal_embryonic_tissue0.70639303
88MP0002877_abnormal_melanocyte_morpholog0.70609002
89MP0002098_abnormal_vibrissa_morphology0.69340553
90MP0000750_abnormal_muscle_regeneration0.67335350
91MP0004130_abnormal_muscle_cell0.66758469
92MP0004215_abnormal_myocardial_fiber0.64814301
93MP0005253_abnormal_eye_physiology0.64667801
94MP0001661_extended_life_span0.62410572
95MP0009764_decreased_sensitivity_to0.61839348
96MP0001270_distended_abdomen0.61297049
97MP0003119_abnormal_digestive_system0.60221017
98MP0004858_abnormal_nervous_system0.59847777
99MP0001765_abnormal_ion_homeostasis0.59762261
100MP0000358_abnormal_cell_content/0.58825685

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.00648199
2Conjunctival hamartoma (HP:0100780)5.90676442
3Abnormal rod and cone electroretinograms (HP:0008323)4.88518069
4Severe visual impairment (HP:0001141)3.61647695
5Bone cyst (HP:0012062)3.60758705
6Oligodontia (HP:0000677)3.59568969
7Palpitations (HP:0001962)3.59125800
8Abnormal number of erythroid precursors (HP:0012131)3.58845785
9Hamartoma of the eye (HP:0010568)3.44010395
10Abnormality of macular pigmentation (HP:0008002)3.42426231
11Meningioma (HP:0002858)3.39371298
12IgM deficiency (HP:0002850)3.07417792
13Partial agenesis of the corpus callosum (HP:0001338)3.06140359
14Long nose (HP:0003189)2.99697757
15IgG deficiency (HP:0004315)2.90407951
16Abnormality of cells of the erythroid lineage (HP:0012130)2.86567685
17Furrowed tongue (HP:0000221)2.80281048
18Round ear (HP:0100830)2.78493108
19Myoglobinuria (HP:0002913)2.76476410
20Persistence of primary teeth (HP:0006335)2.68223164
21Abnormality of the labia minora (HP:0012880)2.66905487
22Distal arthrogryposis (HP:0005684)2.65347410
23Type II lissencephaly (HP:0007260)2.58948444
24Abolished electroretinogram (ERG) (HP:0000550)2.57376665
25Bradycardia (HP:0001662)2.56378710
26Central scotoma (HP:0000603)2.55552475
27Anteriorly placed anus (HP:0001545)2.53134673
28Microretrognathia (HP:0000308)2.51893252
29Hyperthyroidism (HP:0000836)2.51432658
30Broad hallux (HP:0010055)2.49493682
31Constricted visual fields (HP:0001133)2.47018431
32Hypoplasia of the uterus (HP:0000013)2.46514453
33Abnormal number of incisors (HP:0011064)2.45785755
34Palpebral edema (HP:0100540)2.45499932
35Premature skin wrinkling (HP:0100678)2.43097902
36Hypoplasia of the pons (HP:0012110)2.42600702
37Symphalangism affecting the phalanges of the hand (HP:0009773)2.42244044
38Seborrheic dermatitis (HP:0001051)2.36960980
39Cerebral hypomyelination (HP:0006808)2.31230496
40Selective tooth agenesis (HP:0001592)2.31166664
41Acute lymphatic leukemia (HP:0006721)2.30958614
42Decreased central vision (HP:0007663)2.28327416
43Hypogonadotrophic hypogonadism (HP:0000044)2.28265180
44Paralysis (HP:0003470)2.27866396
45Hypoparathyroidism (HP:0000829)2.26704122
46Hypoplastic pelvis (HP:0008839)2.26417180
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24876253
48Prostate neoplasm (HP:0100787)2.20551926
49Hyperinsulinemic hypoglycemia (HP:0000825)2.19711156
50Impaired smooth pursuit (HP:0007772)2.16855338
51Mesomelia (HP:0003027)2.10674535
52Attenuation of retinal blood vessels (HP:0007843)2.10489736
53Hepatocellular necrosis (HP:0001404)2.08017344
54Congenital stationary night blindness (HP:0007642)2.05668108
55Abnormality of the periventricular white matter (HP:0002518)2.04999535
56Atrioventricular block (HP:0001678)2.02799469
57Multiple lipomas (HP:0001012)2.02456139
58Abnormality of the proximal phalanges of the hand (HP:0009834)2.01031425
59Mucosal telangiectasiae (HP:0100579)2.00064514
60Hypoventilation (HP:0002791)1.99405639
61Goiter (HP:0000853)1.98836558
62Verrucae (HP:0200043)1.97164677
63Papilloma (HP:0012740)1.97164677
64Exercise-induced myalgia (HP:0003738)1.96412986
65Stomach cancer (HP:0012126)1.94026715
66Hepatic necrosis (HP:0002605)1.92559193
67Melanoma (HP:0002861)1.92548562
68True hermaphroditism (HP:0010459)1.92340535
69Abnormality of the pons (HP:0007361)1.92204561
70Abnormality of the frontal sinuses (HP:0002687)1.92031077
71High pitched voice (HP:0001620)1.91383890
72Bowel incontinence (HP:0002607)1.91255217
73Redundant skin (HP:0001582)1.87431278
74Nemaline bodies (HP:0003798)1.86869877
75Radial bowing (HP:0002986)1.86049420
76Broad toe (HP:0001837)1.85251254
77Abnormal umbilical cord blood vessels (HP:0011403)1.84588089
78Single umbilical artery (HP:0001195)1.84588089
79Abnormality of the fetal cardiovascular system (HP:0010948)1.84588089
80Calcaneovalgus deformity (HP:0001848)1.83078031
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82114128
82Adenoma sebaceum (HP:0009720)1.81758832
83Angiofibromas (HP:0010615)1.81758832
84Abnormality of the columella (HP:0009929)1.81035942
85Exostoses (HP:0100777)1.80814168
86Scotoma (HP:0000575)1.77413274
87Abnormal large intestine physiology (HP:0012700)1.76683236
88Cavernous hemangioma (HP:0001048)1.76595800
89Gastrointestinal stroma tumor (HP:0100723)1.74773739
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.74711685
91Difficulty climbing stairs (HP:0003551)1.74257599
92Pustule (HP:0200039)1.73863407
93Abnormally folded helix (HP:0008544)1.71833581
94Macroorchidism (HP:0000053)1.71787216
95Synostosis involving the elbow (HP:0003938)1.71779794
96Humeroradial synostosis (HP:0003041)1.71779794
97B lymphocytopenia (HP:0010976)1.71574835
98Small hand (HP:0200055)1.71551430
99Muscle fiber inclusion bodies (HP:0100299)1.68754421
100Aplasia/hypoplasia of the uterus (HP:0008684)1.68306918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.02835992
2NME25.52622716
3TAF13.67456217
4VRK22.85108060
5TLK12.75138021
6ZAK2.47858610
7LMTK22.32752377
8EPHA22.17504132
9SMG12.13947338
10MAP4K22.09546366
11GRK62.08540252
12BCKDK2.05968389
13EPHA32.04582198
14VRK11.96739456
15TESK21.93789114
16MAP3K131.92182944
17MAP2K31.77675029
18PHKG21.77317706
19PHKG11.77317706
20NUAK11.61446482
21MAP2K61.43949629
22EPHB11.42541801
23SIK21.40008225
24MAP3K61.30759207
25CDK191.26510571
26LATS11.25647728
27TRIB31.24778379
28MAP4K11.20485661
29TAOK31.20010697
30BUB11.19150984
31MATK1.09577932
32KIT1.08816490
33SIK11.07072159
34NLK1.05070431
35NEK90.99911609
36MAPKAPK30.99903818
37ICK0.93289549
38RPS6KB20.92823439
39SCYL20.88498693
40DAPK10.86818986
41FLT30.86433842
42AURKA0.85214436
43CHEK20.83732462
44PAK60.80996995
45FGFR40.80108005
46MOS0.78706625
47TAOK20.78070531
48MAP3K140.76081486
49PASK0.76043966
50TESK10.70340125
51RPS6KA40.69539053
52TEC0.69331616
53MYLK0.67819340
54MAP2K20.67172450
55HIPK20.66974062
56RPS6KA50.66862820
57CDK120.65348954
58MST1R0.65035412
59TRPM70.60553218
60NEK10.58788006
61NTRK10.58225977
62DYRK20.57108399
63CDK90.55962850
64RPS6KA20.55319694
65TBK10.54294014
66DAPK30.52665824
67IRAK10.51923963
68CDK40.51632660
69PAK20.51237310
70ITK0.50411785
71ZAP700.49062063
72LIMK10.45760811
73AURKB0.43272992
74PINK10.41032867
75RPS6KC10.39110141
76RPS6KL10.39110141
77CAMKK10.38942496
78MAP3K90.38347960
79TYRO30.38293856
80ALK0.37810840
81CDC70.34707778
82RPS6KA60.33278423
83SIK30.32894685
84ATR0.31281774
85KDR0.28377142
86IKBKB0.27582866
87CSF1R0.27394988
88MAPKAPK20.27108195
89STK380.26501826
90MAPK70.25866442
91MAP2K10.25619776
92PAK40.24814717
93EIF2AK20.24029359
94INSRR0.23233095
95CSNK1G30.22397222
96CDK60.21647546
97CAMKK20.21397627
98MST40.21255374
99CHEK10.19807798
100FER0.19641329

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.16105050
2RNA polymerase_Homo sapiens_hsa030203.26901939
3Caffeine metabolism_Homo sapiens_hsa002323.10914059
4Systemic lupus erythematosus_Homo sapiens_hsa053222.80770286
5Selenocompound metabolism_Homo sapiens_hsa004502.61964786
6Nitrogen metabolism_Homo sapiens_hsa009102.41532710
7Arginine biosynthesis_Homo sapiens_hsa002202.27568522
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.24629565
9Ribosome_Homo sapiens_hsa030102.16146468
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12863686
11Spliceosome_Homo sapiens_hsa030401.92541722
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87933960
13Alcoholism_Homo sapiens_hsa050341.79469045
14Pyrimidine metabolism_Homo sapiens_hsa002401.68853104
15DNA replication_Homo sapiens_hsa030301.68587908
16RNA transport_Homo sapiens_hsa030131.62915562
17Pancreatic secretion_Homo sapiens_hsa049721.53943253
18Renin-angiotensin system_Homo sapiens_hsa046141.50598022
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49963004
20Base excision repair_Homo sapiens_hsa034101.49377960
21Fat digestion and absorption_Homo sapiens_hsa049751.48974369
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47505397
23Biosynthesis of amino acids_Homo sapiens_hsa012301.46939515
24Vitamin digestion and absorption_Homo sapiens_hsa049771.44468817
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38546401
26Homologous recombination_Homo sapiens_hsa034401.36504762
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30128654
28Fructose and mannose metabolism_Homo sapiens_hsa000511.25245767
29Tight junction_Homo sapiens_hsa045301.25095203
30Carbon metabolism_Homo sapiens_hsa012001.24471318
31Melanoma_Homo sapiens_hsa052181.22269509
32Tryptophan metabolism_Homo sapiens_hsa003801.21831906
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21725751
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18270142
35Hedgehog signaling pathway_Homo sapiens_hsa043401.16927044
36Phototransduction_Homo sapiens_hsa047441.16113985
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14922304
38Sulfur relay system_Homo sapiens_hsa041221.13381032
39p53 signaling pathway_Homo sapiens_hsa041151.12964308
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.11318615
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08025908
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07242109
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05477884
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99077517
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.97977432
46Gastric acid secretion_Homo sapiens_hsa049710.95626302
47Regulation of autophagy_Homo sapiens_hsa041400.94871499
48Insulin secretion_Homo sapiens_hsa049110.93558299
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90939070
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.90459306
51Glutathione metabolism_Homo sapiens_hsa004800.87787825
52Mismatch repair_Homo sapiens_hsa034300.86228979
53Purine metabolism_Homo sapiens_hsa002300.85815310
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85183806
55Protein export_Homo sapiens_hsa030600.84308658
56Viral carcinogenesis_Homo sapiens_hsa052030.81948508
57Galactose metabolism_Homo sapiens_hsa000520.81683653
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78682221
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75385205
60Protein digestion and absorption_Homo sapiens_hsa049740.65798268
61Hematopoietic cell lineage_Homo sapiens_hsa046400.62459503
62Proteasome_Homo sapiens_hsa030500.60984190
63Glycerolipid metabolism_Homo sapiens_hsa005610.60686866
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60469783
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.60126850
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58248896
67Hepatitis C_Homo sapiens_hsa051600.55850812
68Salivary secretion_Homo sapiens_hsa049700.55802091
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55094280
70One carbon pool by folate_Homo sapiens_hsa006700.53417217
71Thyroid hormone synthesis_Homo sapiens_hsa049180.52140189
72Huntingtons disease_Homo sapiens_hsa050160.51778553
73RNA degradation_Homo sapiens_hsa030180.51272515
74Basal cell carcinoma_Homo sapiens_hsa052170.50967040
75Glucagon signaling pathway_Homo sapiens_hsa049220.49956921
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49171196
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47300378
78Oxytocin signaling pathway_Homo sapiens_hsa049210.47110051
79Pyruvate metabolism_Homo sapiens_hsa006200.47012762
80Pentose phosphate pathway_Homo sapiens_hsa000300.46928725
81Legionellosis_Homo sapiens_hsa051340.44819443
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.44696543
83Dilated cardiomyopathy_Homo sapiens_hsa054140.43980258
84MAPK signaling pathway_Homo sapiens_hsa040100.42448292
85Hippo signaling pathway_Homo sapiens_hsa043900.42236371
86Melanogenesis_Homo sapiens_hsa049160.42124415
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41475717
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40778358
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40327106
90Fanconi anemia pathway_Homo sapiens_hsa034600.39907963
91Oocyte meiosis_Homo sapiens_hsa041140.39077150
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38139757
93Chemical carcinogenesis_Homo sapiens_hsa052040.36420192
94mRNA surveillance pathway_Homo sapiens_hsa030150.34528898
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.34319624
96Starch and sucrose metabolism_Homo sapiens_hsa005000.33563223
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33538700
98Epstein-Barr virus infection_Homo sapiens_hsa051690.32942160
99Small cell lung cancer_Homo sapiens_hsa052220.31725563
100Vibrio cholerae infection_Homo sapiens_hsa051100.31527544

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