ACTR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.93030635
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.84724715
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.69726639
4glutamate secretion (GO:0014047)5.22282587
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13626693
6synaptic vesicle exocytosis (GO:0016079)5.01528787
7locomotory exploration behavior (GO:0035641)4.85324528
8regulation of synaptic vesicle exocytosis (GO:2000300)4.71631108
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.36669765
10vocalization behavior (GO:0071625)4.21657659
11regulation of synaptic vesicle transport (GO:1902803)4.16342043
12neurotransmitter secretion (GO:0007269)4.16085962
13negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.09483712
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.92569727
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90458427
16neuronal action potential propagation (GO:0019227)3.90128514
17regulation of synapse structural plasticity (GO:0051823)3.89810618
18sodium ion export (GO:0071436)3.89187364
19regulation of glutamate receptor signaling pathway (GO:1900449)3.85952434
20activation of protein kinase A activity (GO:0034199)3.82300980
21negative regulation of erythrocyte differentiation (GO:0045647)3.81109061
22cellular potassium ion homeostasis (GO:0030007)3.77132636
23layer formation in cerebral cortex (GO:0021819)3.76159757
24proline transport (GO:0015824)3.75636315
25cell communication by electrical coupling (GO:0010644)3.73170352
26regulation of neuronal synaptic plasticity (GO:0048168)3.72737354
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71334747
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.67242622
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.62577059
30protein localization to synapse (GO:0035418)3.54336641
31exploration behavior (GO:0035640)3.50502596
32Golgi transport vesicle coating (GO:0048200)3.48065526
33COPI coating of Golgi vesicle (GO:0048205)3.48065526
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45752965
35retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.44244487
36positive regulation of synapse maturation (GO:0090129)3.43171903
37negative regulation of Ras GTPase activity (GO:0034261)3.40845090
38mannose metabolic process (GO:0006013)3.38347493
39plasma membrane repair (GO:0001778)3.36387234
40neuromuscular process controlling posture (GO:0050884)3.31058851
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.30820384
42cerebellar Purkinje cell layer development (GO:0021680)3.19393953
43creatine metabolic process (GO:0006600)3.18119980
44membrane depolarization during action potential (GO:0086010)3.14919209
45gamma-aminobutyric acid transport (GO:0015812)3.14639369
46cerebellar granule cell differentiation (GO:0021707)3.14258759
47negative regulation of microtubule polymerization (GO:0031115)3.13749917
48neurotransmitter transport (GO:0006836)3.12804285
49neuromuscular process controlling balance (GO:0050885)3.12068219
50protein retention in ER lumen (GO:0006621)3.08796462
51cerebellar Purkinje cell differentiation (GO:0021702)3.04354467
52regulation of synaptic plasticity (GO:0048167)3.03251882
53regulation of neurotransmitter secretion (GO:0046928)3.02752512
54cell communication involved in cardiac conduction (GO:0086065)3.02581781
55activation of MAPKKK activity (GO:0000185)3.01715540
56neurotransmitter-gated ion channel clustering (GO:0072578)2.99459483
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99309907
58regulation of amyloid precursor protein catabolic process (GO:1902991)2.97269053
59synaptic transmission, glutamatergic (GO:0035249)2.97262158
60alanine transport (GO:0032328)2.95615565
61cytoskeletal anchoring at plasma membrane (GO:0007016)2.94136280
62ionotropic glutamate receptor signaling pathway (GO:0035235)2.93489900
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91453717
64vesicle transport along microtubule (GO:0047496)2.91374193
65regulation of neurotransmitter levels (GO:0001505)2.91363185
66regulation of beta-amyloid formation (GO:1902003)2.89085423
67regulation of sodium ion transmembrane transporter activity (GO:2000649)2.88910637
68regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87836341
69neuron-neuron synaptic transmission (GO:0007270)2.87396650
70positive regulation of membrane potential (GO:0045838)2.86825817
71signal complex assembly (GO:0007172)2.86580051
72membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85735679
73neuron cell-cell adhesion (GO:0007158)2.85503121
74synaptic vesicle endocytosis (GO:0048488)2.84081345
75glycine transport (GO:0015816)2.83619630
76membrane repolarization (GO:0086009)2.83282929
77peptidyl-lysine dimethylation (GO:0018027)2.82589915
78dendrite morphogenesis (GO:0048813)2.81057339
79regulation of neurotransmitter transport (GO:0051588)2.80878523
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80694286
81potassium ion import (GO:0010107)2.80592962
82regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80221214
83positive regulation of neurotransmitter transport (GO:0051590)2.79683409
84regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.79559898
85cell migration in hindbrain (GO:0021535)2.77284422
86long-term memory (GO:0007616)2.76795935
87regulation of postsynaptic membrane potential (GO:0060078)2.76322374
88regulation of ARF GTPase activity (GO:0032312)2.76261889
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73986810
903-UTR-mediated mRNA stabilization (GO:0070935)2.73830755
91innervation (GO:0060384)2.72397487
92positive regulation of neurotransmitter secretion (GO:0001956)2.69036177
93regulation of clathrin-mediated endocytosis (GO:2000369)2.68974522
94positive regulation of fibroblast migration (GO:0010763)2.68819685
95positive regulation of potassium ion transmembrane transport (GO:1901381)2.68500408
96protein localization to endosome (GO:0036010)2.67685352
97cellular sodium ion homeostasis (GO:0006883)2.67676252
98dendritic spine morphogenesis (GO:0060997)2.67209215
99regulation of dendritic spine morphogenesis (GO:0061001)2.66928357
100regulation of membrane repolarization (GO:0060306)2.66363950
101chemosensory behavior (GO:0007635)2.66264216
102neuronal ion channel clustering (GO:0045161)2.66242093
103negative regulation of Ras protein signal transduction (GO:0046580)2.66026612
104regulation of extracellular matrix disassembly (GO:0010715)2.64514853
105organelle transport along microtubule (GO:0072384)2.63905670
106positive regulation of sodium ion transport (GO:0010765)2.63730212
107neuromuscular process (GO:0050905)2.62093955
108establishment of nucleus localization (GO:0040023)2.62055398
109regulation of autophagic vacuole assembly (GO:2000785)2.61518469
110negative regulation of T cell receptor signaling pathway (GO:0050860)2.60637287
111regulation of ion transmembrane transporter activity (GO:0032412)2.60370705
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.60276893
113regulation of ARF protein signal transduction (GO:0032012)2.60225818
114positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.59507073
115regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.59467328
116neuromuscular synaptic transmission (GO:0007274)2.59432389
117negative regulation of cell size (GO:0045792)2.58827778
118long-term synaptic potentiation (GO:0060291)2.58760792
119regulation of voltage-gated calcium channel activity (GO:1901385)2.58447747
120regulation of vesicle fusion (GO:0031338)2.58384361
121potassium ion homeostasis (GO:0055075)2.58200332
122prepulse inhibition (GO:0060134)2.58124477
123regulation of sodium ion transmembrane transport (GO:1902305)2.57192802
124positive regulation of Rap GTPase activity (GO:0032854)2.56784480
125membrane depolarization (GO:0051899)2.56764342
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.56037883
127regulation of early endosome to late endosome transport (GO:2000641)2.54777648
128membrane repolarization during action potential (GO:0086011)2.54709836
129negative regulation of small GTPase mediated signal transduction (GO:0051058)2.51617752
130barbed-end actin filament capping (GO:0051016)2.50403121
131negative regulation of GTP catabolic process (GO:0033125)2.48258773
132negative regulation of GTPase activity (GO:0034260)2.48258773
133dopamine receptor signaling pathway (GO:0007212)2.47465109
134response to parathyroid hormone (GO:0071107)2.47014304
135negative regulation of nucleotide catabolic process (GO:0030812)2.45928922
136negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44594710
137peptidyl-tyrosine autophosphorylation (GO:0038083)2.44264038
138negative regulation of cell killing (GO:0031342)2.43272554
139negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43272554
140G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.43129442
141regulation of cellular amide metabolic process (GO:0034248)2.41816589
142regulation of synapse maturation (GO:0090128)2.38826413
143positive regulation of protein dephosphorylation (GO:0035307)2.38655328
144cell-cell junction maintenance (GO:0045217)2.36756237
145thymic T cell selection (GO:0045061)2.35780150
146protein targeting to plasma membrane (GO:0072661)2.35526587
147retrograde transport, endosome to Golgi (GO:0042147)2.34082444
148regulation of vacuole organization (GO:0044088)2.33921249
149stress fiber assembly (GO:0043149)2.33593269
150positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.28939285
151regulation of defense response to virus by virus (GO:0050690)2.28791788
152response to muramyl dipeptide (GO:0032495)2.28474844
153intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.28244833
154localization within membrane (GO:0051668)2.28104611
155adherens junction assembly (GO:0034333)2.27332202
156NADH metabolic process (GO:0006734)2.27090814
157cardiac muscle contraction (GO:0060048)2.26420185
158cell-substrate adherens junction assembly (GO:0007045)2.24400556
159focal adhesion assembly (GO:0048041)2.24400556
160cellular response to catecholamine stimulus (GO:0071870)2.24389040
161cellular response to monoamine stimulus (GO:0071868)2.24389040
162negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.23451385
163positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.22961859
164negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)2.20761016
165negative regulation of purine nucleotide catabolic process (GO:0033122)2.20481990
166regulation of extracellular matrix organization (GO:1903053)2.20433165
167negative regulation of ERBB signaling pathway (GO:1901185)2.15755465
168NIK/NF-kappaB signaling (GO:0038061)2.15578273
169regulation of cholesterol biosynthetic process (GO:0045540)2.15133857
170activation of Rac GTPase activity (GO:0032863)2.14510220
171modulation by symbiont of host cellular process (GO:0044068)2.13268842
172regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.11619048
173negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.11577698
174autophagic vacuole fusion (GO:0000046)2.09821934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90980526
2RARB_27405468_Chip-Seq_BRAIN_Mouse2.90421033
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73259552
4DROSHA_22980978_ChIP-Seq_HELA_Human2.63997377
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63147488
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62248083
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58459419
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55831293
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55831293
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.45415989
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37560776
12VDR_21846776_ChIP-Seq_THP-1_Human2.36817825
13REST_21632747_ChIP-Seq_MESCs_Mouse2.32312713
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31240310
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30986511
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30962622
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.25908712
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.18958571
19* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.18411178
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.18151898
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14065056
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13687456
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.07023041
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06074716
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.03205516
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02925477
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98579761
28TCF7_22412390_ChIP-Seq_EML_Mouse1.97452494
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.96271855
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.94523735
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91502040
32MYC_22102868_ChIP-Seq_BL_Human1.91426112
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.89863111
34GBX2_23144817_ChIP-Seq_PC3_Human1.88767280
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87451903
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.85660811
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.84481572
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80872093
39KDM2B_26808549_Chip-Seq_K562_Human1.80062559
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79082254
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.78418626
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78281187
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77309547
44P68_20966046_ChIP-Seq_HELA_Human1.77023512
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.76705631
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76233593
47* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65483240
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.61572021
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.57490281
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55159320
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51112961
52LXR_22292898_ChIP-Seq_THP-1_Human1.50346219
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48512991
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48091345
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45858201
56SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45655371
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44515838
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40896704
59* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39237391
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38215420
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37474033
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35427697
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35037399
64MAF_26560356_Chip-Seq_TH2_Human1.33804494
65VDR_24763502_ChIP-Seq_THP-1_Human1.33254425
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32390792
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.31842073
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30437317
69MAF_26560356_Chip-Seq_TH1_Human1.29507478
70ZNF263_19887448_ChIP-Seq_K562_Human1.28398057
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.27609555
72BCL6_27268052_Chip-Seq_Bcells_Human1.27140829
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.26082952
74CLOCK_20551151_ChIP-Seq_293T_Human1.25345908
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.25031254
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23928719
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.23556532
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23538553
79BCOR_27268052_Chip-Seq_Bcells_Human1.22912989
80ZNF274_21170338_ChIP-Seq_K562_Hela1.20340643
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.19844414
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18372102
83AR_19668381_ChIP-Seq_PC3_Human1.18311097
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15807315
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15259696
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15171670
87CTCF_27219007_Chip-Seq_Bcells_Human1.15019171
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15016431
89KDM2B_26808549_Chip-Seq_DND41_Human1.14384223
90UTX_26944678_Chip-Seq_JUKART_Human1.14124641
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12929863
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12614762
93* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12005984
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11489961
95* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11454508
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11078961
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09182054
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09125796
99AR_21572438_ChIP-Seq_LNCaP_Human1.08012988
100CREB1_26743006_Chip-Seq_LNCaP_Human1.07216658
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06756967
102TP63_22573176_ChIP-Seq_HFKS_Human1.06726971
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.06284044
104SA1_27219007_Chip-Seq_Bcells_Human1.03765188
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02578527
106EP300_21415370_ChIP-Seq_HL-1_Mouse1.02084295
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.01974865
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01298280
109SMC4_20622854_ChIP-Seq_HELA_Human1.01106473
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00899827
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00419823
112SMAD4_21799915_ChIP-Seq_A2780_Human1.00394770
113* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00242236
114AHR_22903824_ChIP-Seq_MCF-7_Human0.99999516
115RUNX1_27514584_Chip-Seq_MCF-7_Human0.99021492
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98629760
117TP53_22127205_ChIP-Seq_IMR90_Human0.97604394
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.97406742
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97275617
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97158161
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97045016
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.97037346
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96868333
124PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96790281
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96305844
126KLF4_19829295_ChIP-Seq_ESCs_Human0.96245763
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95551982
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95409956
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95226165
130RXR_22158963_ChIP-Seq_LIVER_Mouse0.94865238
131CTCF_21964334_Chip-Seq_Bcells_Human0.94805797
132* ETS1_21867929_ChIP-Seq_TH2_Mouse0.94588669
133RACK7_27058665_Chip-Seq_MCF-7_Human0.94155248
134CTCF_26484167_Chip-Seq_Bcells_Mouse0.93952879
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93788151
136CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93087683
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92805671
138PHF8_20622854_ChIP-Seq_HELA_Human0.92584042
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92565132
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.91511144
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.91160831
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91079976
143TP53_23651856_ChIP-Seq_MEFs_Mouse0.90303852
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89583230
145RXR_22108803_ChIP-Seq_LS180_Human0.89467248
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88962514
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88040581
148UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87422111
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.86956685
150ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85914341
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85507837
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85412917
153MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82638930
154NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81454335
155OCT4_19829295_ChIP-Seq_ESCs_Human0.81415132
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80807364
157CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80245709
158SMAD4_21741376_ChIP-Seq_ESCs_Human0.79647055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.19347995
2MP0003303_peritoneal_inflammation4.30654461
3MP0004270_analgesia3.62633911
4MP0000566_synostosis3.56118190
5MP0003635_abnormal_synaptic_transmissio3.52082212
6MP0003880_abnormal_central_pattern2.99817518
7MP0001968_abnormal_touch/_nociception2.90611770
8MP0004858_abnormal_nervous_system2.71756012
9MP0002063_abnormal_learning/memory/cond2.68584628
10MP0009745_abnormal_behavioral_response2.57485324
11MP0002064_seizures2.56585721
12MP0009046_muscle_twitch2.50933750
13MP0002734_abnormal_mechanical_nocicepti2.38462959
14MP0005451_abnormal_body_composition2.37960569
15MP0002822_catalepsy2.37668534
16MP0005058_abnormal_lysosome_morphology2.35877215
17MP0000751_myopathy2.26292842
18MP0002736_abnormal_nociception_after2.23418485
19MP0009780_abnormal_chondrocyte_physiolo2.20593771
20MP0000604_amyloidosis2.16151159
21MP0002735_abnormal_chemical_nociception2.12959843
22MP0002272_abnormal_nervous_system2.07368190
23MP0002572_abnormal_emotion/affect_behav2.04296602
24MP0002909_abnormal_adrenal_gland2.01052944
25MP0000013_abnormal_adipose_tissue1.92273189
26MP0001348_abnormal_lacrimal_gland1.89777914
27MP0002733_abnormal_thermal_nociception1.89607304
28MP0003436_decreased_susceptibility_to1.86011939
29MP0002837_dystrophic_cardiac_calcinosis1.85662570
30MP0005423_abnormal_somatic_nervous1.84832076
31MP0004811_abnormal_neuron_physiology1.82608236
32MP0004510_myositis1.75748218
33MP0004145_abnormal_muscle_electrophysio1.75253677
34MP0003705_abnormal_hypodermis_morpholog1.73969630
35MP0001970_abnormal_pain_threshold1.71758341
36MP0003329_amyloid_beta_deposits1.70987407
37MP0008260_abnormal_autophagy1.70082890
38MP0009840_abnormal_foam_cell1.69072361
39MP0004233_abnormal_muscle_weight1.67751605
40MP0008569_lethality_at_weaning1.64968292
41MP0003172_abnormal_lysosome_physiology1.63622279
42MP0003283_abnormal_digestive_organ1.61265730
43MP0002184_abnormal_innervation1.60958016
44MP0002067_abnormal_sensory_capabilities1.60542153
45MP0001486_abnormal_startle_reflex1.59210825
46MP0001501_abnormal_sleep_pattern1.53439315
47MP0001440_abnormal_grooming_behavior1.49906681
48MP0003300_gastrointestinal_ulcer1.48636449
49MP0005623_abnormal_meninges_morphology1.47022398
50MP0003122_maternal_imprinting1.46696518
51MP0005666_abnormal_adipose_tissue1.44218686
52MP0003879_abnormal_hair_cell1.42684103
53MP0000747_muscle_weakness1.41860038
54MP0008961_abnormal_basal_metabolism1.39615760
55MP0000955_abnormal_spinal_cord1.37536256
56MP0001984_abnormal_olfaction1.36839821
57MP0005166_decreased_susceptibility_to1.36015414
58MP0003690_abnormal_glial_cell1.34506875
59MP0003191_abnormal_cellular_cholesterol1.32062542
60MP0004185_abnormal_adipocyte_glucose1.29241087
61MP0003763_abnormal_thymus_physiology1.28970280
62MP0003183_abnormal_peptide_metabolism1.28209433
63MP0002557_abnormal_social/conspecific_i1.28001956
64MP0000678_abnormal_parathyroid_gland1.27602756
65MP0000749_muscle_degeneration1.26254006
66MP0006276_abnormal_autonomic_nervous1.25369240
67MP0003453_abnormal_keratinocyte_physiol1.25347370
68MP0005375_adipose_tissue_phenotype1.23778323
69MP0005386_behavior/neurological_phenoty1.23401419
70MP0004924_abnormal_behavior1.23401419
71MP0001849_ear_inflammation1.22168580
72MP0006082_CNS_inflammation1.21712538
73MP0002882_abnormal_neuron_morphology1.20118907
74MP0003633_abnormal_nervous_system1.19562712
75MP0004130_abnormal_muscle_cell1.19502825
76MP0001958_emphysema1.18408670
77MP0003646_muscle_fatigue1.17650647
78MP0002066_abnormal_motor_capabilities/c1.17303026
79MP0001663_abnormal_digestive_system1.16409367
80MP0004215_abnormal_myocardial_fiber1.16008665
81MP0000003_abnormal_adipose_tissue1.15706194
82MP0004947_skin_inflammation1.14748231
83MP0010234_abnormal_vibrissa_follicle1.11412571
84MP0004084_abnormal_cardiac_muscle1.11218002
85MP0005409_darkened_coat_color1.11088475
86MP0009278_abnormal_bone_marrow1.11083522
87MP0000920_abnormal_myelination1.09730657
88MP0002269_muscular_atrophy1.07883888
89MP0003279_aneurysm1.07565267
90MP0010155_abnormal_intestine_physiology1.07413873
91MP0005076_abnormal_cell_differentiation1.07219688
92MP0000858_altered_metastatic_potential1.06700311
93MP0004036_abnormal_muscle_relaxation1.06105761
94MP0000778_abnormal_nervous_system1.05436867
95MP0002249_abnormal_larynx_morphology1.04312309
96MP0004085_abnormal_heartbeat1.00392255
97MP0000681_abnormal_thyroid_gland0.98375234
98MP0004087_abnormal_muscle_fiber0.97868886
99MP0001299_abnormal_eye_distance/0.97583466
100MP0003866_abnormal_defecation0.96524631
101MP0004885_abnormal_endolymph0.96097532
102MP0005025_abnormal_response_to0.94503572
103MP0005381_digestive/alimentary_phenotyp0.93508705
104MP0000759_abnormal_skeletal_muscle0.92806049
105MP0010386_abnormal_urinary_bladder0.92330067
106MP0005394_taste/olfaction_phenotype0.92226207
107MP0005499_abnormal_olfactory_system0.92226207
108MP0003091_abnormal_cell_migration0.92208914
109MP0005000_abnormal_immune_tolerance0.90636203
110MP0003631_nervous_system_phenotype0.90427242
111MP0001790_abnormal_immune_system0.89309678
112MP0005387_immune_system_phenotype0.89309678
113MP0004484_altered_response_of0.89222795
114MP0002152_abnormal_brain_morphology0.88910558
115MP0003787_abnormal_imprinting0.88285046
116MP0001664_abnormal_digestion0.88284085
117MP0005620_abnormal_muscle_contractility0.88023475
118MP0001533_abnormal_skeleton_physiology0.86912785
119MP0000569_abnormal_digit_pigmentation0.85843496
120MP0008874_decreased_physiological_sensi0.85760313
121MP0004043_abnormal_pH_regulation0.84609591
122MP0002089_abnormal_postnatal_growth/wei0.83310617
123MP0003075_altered_response_to0.83021137
124MP0002069_abnormal_eating/drinking_beha0.82714213
125MP0005645_abnormal_hypothalamus_physiol0.82511424
126MP0002971_abnormal_brown_adipose0.81677961
127MP0005646_abnormal_pituitary_gland0.81199912
128MP0000685_abnormal_immune_system0.79743791
129MP0000534_abnormal_ureter_morphology0.79633569
130MP0002933_joint_inflammation0.79028893
131MP0003137_abnormal_impulse_conducting0.77254997
132MP0005464_abnormal_platelet_physiology0.77012544
133MP0002653_abnormal_ependyma_morphology0.75816677
134MP0005187_abnormal_penis_morphology0.74721718
135MP0005167_abnormal_blood-brain_barrier0.74668746
136MP0001502_abnormal_circadian_rhythm0.73980608
137MP0009384_cardiac_valve_regurgitation0.73896343
138MP0009333_abnormal_splenocyte_physiolog0.73266004
139MP0003634_abnormal_glial_cell0.73129139
140MP0002419_abnormal_innate_immunity0.73034923
141MP0002998_abnormal_bone_remodeling0.70874203
142MP0002972_abnormal_cardiac_muscle0.70698963
143MP0003045_fibrosis0.70472163
144MP0008872_abnormal_physiological_respon0.70230918
145MP0008775_abnormal_heart_ventricle0.69545680
146MP0002106_abnormal_muscle_physiology0.69336227
147MP0000733_abnormal_muscle_development0.68926593
148MP0002229_neurodegeneration0.68446559
149MP0004142_abnormal_muscle_tone0.67581795
150MP0001177_atelectasis0.67128738
151MP0003123_paternal_imprinting0.66782634
152MP0005369_muscle_phenotype0.66374656
153MP0005535_abnormal_body_temperature0.65536964
154MP0003566_abnormal_cell_adhesion0.65514735
155MP0002896_abnormal_bone_mineralization0.64907755
156MP0005023_abnormal_wound_healing0.64898935
157MP0001915_intracranial_hemorrhage0.64774186
158MP0001800_abnormal_humoral_immune0.64539225
159MP0002420_abnormal_adaptive_immunity0.62834917
160MP0001819_abnormal_immune_cell0.61028826
161MP0003115_abnormal_respiratory_system0.60126288
162MP0005390_skeleton_phenotype0.59784234

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.33037181
2Focal motor seizures (HP:0011153)5.00989627
3Visual hallucinations (HP:0002367)4.28787989
4Focal seizures (HP:0007359)4.25861639
5Action tremor (HP:0002345)3.50767085
6Abnormality of the lower motor neuron (HP:0002366)3.32778172
7Obstructive sleep apnea (HP:0002870)3.27534370
8Atonic seizures (HP:0010819)3.25515584
9Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22360992
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.07230248
11Epileptic encephalopathy (HP:0200134)3.04982148
12Neurofibrillary tangles (HP:0002185)3.02113428
13Ankle clonus (HP:0011448)3.01441820
14Absence seizures (HP:0002121)2.95006277
15Generalized tonic-clonic seizures (HP:0002069)2.85441816
16Impaired vibration sensation in the lower limbs (HP:0002166)2.85390163
17Depression (HP:0000716)2.83172766
18Dysmetric saccades (HP:0000641)2.80889816
19Progressive cerebellar ataxia (HP:0002073)2.73675190
20Ventricular fibrillation (HP:0001663)2.72743376
21Pheochromocytoma (HP:0002666)2.72275333
22Poor eye contact (HP:0000817)2.64934747
23Impaired social interactions (HP:0000735)2.64707479
24Abnormal social behavior (HP:0012433)2.64707479
25Cerebral inclusion bodies (HP:0100314)2.64611267
26Supranuclear gaze palsy (HP:0000605)2.63745005
27Myopathic facies (HP:0002058)2.61875224
28Dialeptic seizures (HP:0011146)2.61214550
29Febrile seizures (HP:0002373)2.59689129
30Foot dorsiflexor weakness (HP:0009027)2.54082849
31Bundle branch block (HP:0011710)2.53530317
32Vertebral compression fractures (HP:0002953)2.53317243
33Urinary bladder sphincter dysfunction (HP:0002839)2.51803870
34Rhabdomyolysis (HP:0003201)2.50627313
35Insidious onset (HP:0003587)2.44990388
36Termporal pattern (HP:0011008)2.44990388
37Distal upper limb amyotrophy (HP:0007149)2.44634965
38Upper limb amyotrophy (HP:0009129)2.44634965
39Urinary urgency (HP:0000012)2.43791822
40Torticollis (HP:0000473)2.42546847
41Growth hormone excess (HP:0000845)2.42512329
42Myotonia (HP:0002486)2.42012814
43Exercise-induced myalgia (HP:0003738)2.40722866
44Distal lower limb muscle weakness (HP:0009053)2.39492424
45Postural instability (HP:0002172)2.37124756
46Neuroendocrine neoplasm (HP:0100634)2.34234292
47Neuronal loss in central nervous system (HP:0002529)2.33435466
48Distal lower limb amyotrophy (HP:0008944)2.33391426
49Stridor (HP:0010307)2.32790407
50Hypercortisolism (HP:0001578)2.29051005
51Dysdiadochokinesis (HP:0002075)2.27611419
52Abnormality of the foot musculature (HP:0001436)2.26748251
53Annular pancreas (HP:0001734)2.26411046
54Resting tremor (HP:0002322)2.26203792
55Increased connective tissue (HP:0009025)2.26166773
56Sudden death (HP:0001699)2.25769960
57Hyperparathyroidism (HP:0000843)2.23677981
58Abnormality of pain sensation (HP:0010832)2.23532870
59Impaired pain sensation (HP:0007328)2.23532870
60Anxiety (HP:0000739)2.23418846
61Truncal ataxia (HP:0002078)2.22582248
62Achilles tendon contracture (HP:0001771)2.21689644
63Pointed chin (HP:0000307)2.21198361
64Hand muscle atrophy (HP:0009130)2.20317558
65Focal dystonia (HP:0004373)2.19856559
66Dysostosis multiplex (HP:0000943)2.19207614
67Insomnia (HP:0100785)2.18265682
68Eczematoid dermatitis (HP:0000976)2.17518162
69Hemiplegia (HP:0002301)2.16031680
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15292228
71Genetic anticipation (HP:0003743)2.14608547
72Deep venous thrombosis (HP:0002625)2.13316653
73Abnormal eating behavior (HP:0100738)2.12229267
74Neoplasm of the heart (HP:0100544)2.10891340
75Rapidly progressive (HP:0003678)2.10482152
76Hypoventilation (HP:0002791)2.07897782
77Neoplasm of the peripheral nervous system (HP:0100007)2.07518958
78Flat acetabular roof (HP:0003180)2.07094760
79Abnormality of the Achilles tendon (HP:0005109)2.06959657
80Exercise-induced muscle cramps (HP:0003710)2.06156509
81Craniofacial dystonia (HP:0012179)2.05106414
82Cerebral aneurysm (HP:0004944)2.05049823
83Nuclear cataract (HP:0100018)2.04936375
84Impaired smooth pursuit (HP:0007772)2.04611007
85Amblyopia (HP:0000646)2.04310362
86Mitral regurgitation (HP:0001653)2.03008528
87Broad face (HP:0000283)2.02668662
88Mildly elevated creatine phosphokinase (HP:0008180)2.01975592
89Asymmetric septal hypertrophy (HP:0001670)2.00586488
90Increased variability in muscle fiber diameter (HP:0003557)1.98708018
91Atelectasis (HP:0100750)1.98006346
92Cellulitis (HP:0100658)1.97842737
93Purpura (HP:0000979)1.97659130
94Gaze-evoked nystagmus (HP:0000640)1.96926820
95Dysmetria (HP:0001310)1.96845580
96Difficulty climbing stairs (HP:0003551)1.95489968
97Colitis (HP:0002583)1.94017716
98Status epilepticus (HP:0002133)1.93214452
99Thin bony cortex (HP:0002753)1.92912288
100Muscle stiffness (HP:0003552)1.92851933
101Protrusio acetabuli (HP:0003179)1.92691495
102Bradykinesia (HP:0002067)1.92659533
103Progressive muscle weakness (HP:0003323)1.88982465
104Hyporeflexia of lower limbs (HP:0002600)1.88766745
105Hammertoe (HP:0001765)1.87582257
106Axonal loss (HP:0003447)1.86353579
107Diplopia (HP:0000651)1.86128582
108Abnormality of binocular vision (HP:0011514)1.86128582
109Turricephaly (HP:0000262)1.85850237
110Shoulder girdle muscle weakness (HP:0003547)1.85530747
111Postural tremor (HP:0002174)1.84976964
112Lower limb muscle weakness (HP:0007340)1.84761148
113Lower limb amyotrophy (HP:0007210)1.84711746
114Difficulty running (HP:0009046)1.84079009
115Ragged-red muscle fibers (HP:0003200)1.83682452
116Peripheral hypomyelination (HP:0007182)1.82919356
117Spastic gait (HP:0002064)1.82776605
118Spinal canal stenosis (HP:0003416)1.82531911
119Impaired vibratory sensation (HP:0002495)1.81784849
120Striae distensae (HP:0001065)1.80882741
121Epileptiform EEG discharges (HP:0011182)1.80835843
122Hyperthyroidism (HP:0000836)1.80606150
123Type 1 muscle fiber predominance (HP:0003803)1.80512111
124Round ear (HP:0100830)1.80441947
125Bulbar palsy (HP:0001283)1.80285832
126Broad-based gait (HP:0002136)1.79874470
127Hyperacusis (HP:0010780)1.79522657
128Prolonged QT interval (HP:0001657)1.79252889
129Interstitial pulmonary disease (HP:0006530)1.76457127
130Gout (HP:0001997)1.75767048
131Hemorrhage of the eye (HP:0011885)1.75409117
132Megalencephaly (HP:0001355)1.75338819
133EEG with generalized epileptiform discharges (HP:0011198)1.75161579
134Mucopolysacchariduria (HP:0008155)1.74385311
135Urinary glycosaminoglycan excretion (HP:0003541)1.74385311
136Agitation (HP:0000713)1.73832630
137Hypsarrhythmia (HP:0002521)1.73250440
138Abnormality of fatty-acid metabolism (HP:0004359)1.73225953
139Abnormal EKG (HP:0003115)1.73218185
140Papilledema (HP:0001085)1.72638066
141Failure to thrive in infancy (HP:0001531)1.72151167
142Myoglobinuria (HP:0002913)1.71814428
143Shallow orbits (HP:0000586)1.71077299
144Menstrual irregularities (HP:0000858)1.70798728
145Abnormality of ocular smooth pursuit (HP:0000617)1.69497346
146Muscle fiber inclusion bodies (HP:0100299)1.68963616
147Long palpebral fissure (HP:0000637)1.68614575
148Increased IgE level (HP:0003212)1.68222991
149Muscle fiber splitting (HP:0003555)1.67759056
150Limb-girdle muscle atrophy (HP:0003797)1.65771391
151Pelvic girdle muscle weakness (HP:0003749)1.64857194
152Abnormality of skeletal muscle fiber size (HP:0012084)1.64670956
153Systemic lupus erythematosus (HP:0002725)1.64050119
154Spinal rigidity (HP:0003306)1.62607092
155Polygenic inheritance (HP:0010982)1.62100854
156Hyperphosphatemia (HP:0002905)1.61971654
157Abnormality of mucopolysaccharide metabolism (HP:0011020)1.60833338
158Abnormality of polysaccharide metabolism (HP:0011012)1.60833338
159Abnormality of glycosaminoglycan metabolism (HP:0004371)1.60833338
160Ulnar deviation of the wrist (HP:0003049)1.60799896
161Diminished motivation (HP:0000745)1.60483361
162Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.60482984
163Generalized amyotrophy (HP:0003700)1.60480758
164J-shaped sella turcica (HP:0002680)1.59648259
165Lower limb asymmetry (HP:0100559)1.59177338
166Decreased motor nerve conduction velocity (HP:0003431)1.58854480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.60351689
2MAP3K93.55656373
3MAP3K113.10677807
4EPHA42.96556501
5TAOK22.80706059
6DAPK22.77553478
7MAP3K42.58152696
8PRKD32.58112250
9MAP2K32.57568729
10TRIB32.56991773
11KSR22.53175719
12MINK12.53007805
13PAK62.52399895
14NTRK12.20665904
15NEK12.15539485
16CAMKK12.04691832
17ERN12.00697698
18MAP3K31.99436625
19ICK1.97867979
20MAP2K41.87556707
21PKN21.86847093
22PHKG21.77950869
23PHKG11.77950869
24RIPK11.70877970
25MKNK21.68632110
26MAP2K71.62965574
27LATS21.62795622
28FGFR41.61738359
29MAP3K21.56380479
30DAPK11.55562222
31KSR11.53481880
32STK381.51014254
33LMTK21.50805527
34SMG11.46592152
35MARK11.36122992
36IRAK31.33078717
37RET1.31831584
38CDK51.28759406
39JAK31.21394175
40CDK191.19043525
41FER1.16934472
42MAP4K11.16428111
43ARAF1.16363161
44PLK21.14950338
45EPHB11.14377058
46CAMKK21.14365294
47PAK31.11552831
48TAOK11.10587744
49TTN1.09505523
50NTRK21.07522408
51PDGFRA1.07167618
52MAP3K121.07095069
53SCYL21.06913807
54PRPF4B1.02783578
55UHMK11.02387720
56GRK51.01894780
57ALK1.01517060
58DDR21.00207262
59PRKCH0.99828231
60MAPK120.96025376
61PRKCG0.95320333
62TYRO30.94375249
63CDK140.89446205
64PTK2B0.88971560
65CDK180.86727915
66MAP2K10.86590321
67DYRK1B0.86579007
68CDK150.85747807
69ZAP700.85700767
70DAPK30.84298950
71SGK4940.82878097
72SGK2230.82878097
73PRKD20.82226799
74TBK10.82121677
75MAP3K10.80762149
76MAP3K70.80642151
77LRRK20.77802062
78MAP3K60.77641115
79CDC42BPA0.76913772
80CAMK10.75955281
81SGK30.75821620
82TYK20.75429825
83SIK20.74209435
84CDK11A0.73150114
85PDK40.72577684
86PDK30.72577684
87LIMK10.72279842
88BRAF0.71881074
89PTK20.71808363
90ABL20.71415263
91MOS0.70996284
92FES0.70928950
93TNK20.69851458
94STK110.68632233
95DMPK0.67932653
96DYRK1A0.67873805
97PDPK10.65103703
98EPHA20.65099559
99TESK20.64302677
100FGFR30.63935522
101PINK10.63039469
102PDK10.61953880
103MAP3K130.61469464
104CAMK2A0.61138166
105BMX0.61082565
106EEF2K0.60041597
107MAP2K20.58858937
108MAPK110.58644496
109HIPK20.57930493
110RIPK40.56976451
111RAF10.54855141
112SGK20.54705350
113CAMK40.53488764
114RPS6KA20.51432396
115PIM20.50078615
116RPS6KC10.49927874
117RPS6KL10.49927874
118CDK120.49117166
119ROCK10.48927950
120EPHA30.48435812
121MAPK70.47508429
122CAMK2B0.46012648
123FGFR10.45515498
124MTOR0.45499342
125CAMK2G0.44973925
126MAP2K60.44609919
127WNK10.44483388
128IRAK20.43489389
129RPS6KA30.43378813
130MAP3K80.42772450
131CAMK1G0.41396040
132TESK10.41097243
133PTK60.41095652
134CAMK2D0.40711734
135MAPK40.40069969
136SGK10.39633545
137JAK10.39518393
138PRKCZ0.39245103
139NME10.38776024
140MAP3K50.38687852
141MARK20.38602004
142MAPKAPK30.37947525
143MAPK100.35695923
144SIK10.35298468
145ROCK20.34887401
146CSNK1G20.34787901

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.35922450
2Olfactory transduction_Homo sapiens_hsa047402.56795310
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47170266
4Other glycan degradation_Homo sapiens_hsa005112.27759326
5Nicotine addiction_Homo sapiens_hsa050332.14098884
6Long-term potentiation_Homo sapiens_hsa047202.13905812
7Circadian entrainment_Homo sapiens_hsa047132.11469779
8Insulin secretion_Homo sapiens_hsa049112.05135370
9GABAergic synapse_Homo sapiens_hsa047272.02142650
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95617856
11Nitrogen metabolism_Homo sapiens_hsa009101.94362336
12Amphetamine addiction_Homo sapiens_hsa050311.91666393
13Dopaminergic synapse_Homo sapiens_hsa047281.86592925
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86517954
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78154278
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77712033
17Morphine addiction_Homo sapiens_hsa050321.72507371
18Glutamatergic synapse_Homo sapiens_hsa047241.72203557
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68312111
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67907898
21Gastric acid secretion_Homo sapiens_hsa049711.67376627
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66372251
23Salivary secretion_Homo sapiens_hsa049701.63382654
24Cholinergic synapse_Homo sapiens_hsa047251.62535586
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59737546
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.48656764
27Oxytocin signaling pathway_Homo sapiens_hsa049211.42945197
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42848609
29B cell receptor signaling pathway_Homo sapiens_hsa046621.36737551
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36267417
31Notch signaling pathway_Homo sapiens_hsa043301.35990323
32Acute myeloid leukemia_Homo sapiens_hsa052211.35752628
33Type II diabetes mellitus_Homo sapiens_hsa049301.35550812
34GnRH signaling pathway_Homo sapiens_hsa049121.34884662
35Collecting duct acid secretion_Homo sapiens_hsa049661.30469973
36Glioma_Homo sapiens_hsa052141.29922530
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26980633
38Gap junction_Homo sapiens_hsa045401.25816329
39Cocaine addiction_Homo sapiens_hsa050301.23837892
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21608229
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21114245
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.20708848
43Taste transduction_Homo sapiens_hsa047421.19449973
44Estrogen signaling pathway_Homo sapiens_hsa049151.17797462
45Renin secretion_Homo sapiens_hsa049241.17213690
46Calcium signaling pathway_Homo sapiens_hsa040201.14863051
47Vibrio cholerae infection_Homo sapiens_hsa051101.14774103
48Dilated cardiomyopathy_Homo sapiens_hsa054141.14714985
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13780605
50Long-term depression_Homo sapiens_hsa047301.13745407
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07672082
52Chronic myeloid leukemia_Homo sapiens_hsa052201.05550780
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00947453
54Glucagon signaling pathway_Homo sapiens_hsa049220.99699883
55Osteoclast differentiation_Homo sapiens_hsa043800.98802958
56cAMP signaling pathway_Homo sapiens_hsa040240.98350486
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96621872
58mTOR signaling pathway_Homo sapiens_hsa041500.95216492
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94696787
60Melanogenesis_Homo sapiens_hsa049160.94179488
61Serotonergic synapse_Homo sapiens_hsa047260.93814432
62Cardiac muscle contraction_Homo sapiens_hsa042600.93225468
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92192751
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91817443
65ErbB signaling pathway_Homo sapiens_hsa040120.91621240
66Pentose phosphate pathway_Homo sapiens_hsa000300.91395832
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90925978
68Inositol phosphate metabolism_Homo sapiens_hsa005620.90517586
69Amoebiasis_Homo sapiens_hsa051460.90421917
70Arginine biosynthesis_Homo sapiens_hsa002200.89818617
71Insulin signaling pathway_Homo sapiens_hsa049100.89308485
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.87382065
73Phenylalanine metabolism_Homo sapiens_hsa003600.85298829
74Prolactin signaling pathway_Homo sapiens_hsa049170.85172296
75Bile secretion_Homo sapiens_hsa049760.84918493
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83562905
77Thyroid hormone synthesis_Homo sapiens_hsa049180.82284940
78T cell receptor signaling pathway_Homo sapiens_hsa046600.81641334
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.81511401
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81307797
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.81002778
82Galactose metabolism_Homo sapiens_hsa000520.80091247
83Pancreatic cancer_Homo sapiens_hsa052120.79602166
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78097853
85Hepatitis C_Homo sapiens_hsa051600.78018454
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.77811086
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76678806
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.76546254
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75426705
90Oocyte meiosis_Homo sapiens_hsa041140.74785762
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74262409
92VEGF signaling pathway_Homo sapiens_hsa043700.72369994
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.71672958
94TNF signaling pathway_Homo sapiens_hsa046680.71657233
95Pancreatic secretion_Homo sapiens_hsa049720.68949244
96Salmonella infection_Homo sapiens_hsa051320.68412501
97Axon guidance_Homo sapiens_hsa043600.68298164
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67941244
99Endometrial cancer_Homo sapiens_hsa052130.67411722
100Dorso-ventral axis formation_Homo sapiens_hsa043200.65133109
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64718522
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64674769
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61658741
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61137476
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59858001
106Endocytosis_Homo sapiens_hsa041440.58845848
107Chemokine signaling pathway_Homo sapiens_hsa040620.58730291
108Rap1 signaling pathway_Homo sapiens_hsa040150.57942138
109Tuberculosis_Homo sapiens_hsa051520.57688511
110MAPK signaling pathway_Homo sapiens_hsa040100.57156625
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57088026
112Non-small cell lung cancer_Homo sapiens_hsa052230.56202483
113Insulin resistance_Homo sapiens_hsa049310.51801478
114Biosynthesis of amino acids_Homo sapiens_hsa012300.51364034
115AMPK signaling pathway_Homo sapiens_hsa041520.50670463
116Carbon metabolism_Homo sapiens_hsa012000.49090209
117Tight junction_Homo sapiens_hsa045300.47836679
118Choline metabolism in cancer_Homo sapiens_hsa052310.47735429
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47353616
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47033870
121Proteoglycans in cancer_Homo sapiens_hsa052050.46781265
122Prion diseases_Homo sapiens_hsa050200.44734316
123Focal adhesion_Homo sapiens_hsa045100.44538503
124Bladder cancer_Homo sapiens_hsa052190.43580210
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.42502209
126Renal cell carcinoma_Homo sapiens_hsa052110.42133377
127Ras signaling pathway_Homo sapiens_hsa040140.41742774
128Pyruvate metabolism_Homo sapiens_hsa006200.40609432
129Butanoate metabolism_Homo sapiens_hsa006500.38986123
130HIF-1 signaling pathway_Homo sapiens_hsa040660.37070630
131Fructose and mannose metabolism_Homo sapiens_hsa000510.36589553
132Circadian rhythm_Homo sapiens_hsa047100.36101428

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