ACTR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.21931710
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.21931710
3antigen processing and presentation of endogenous antigen (GO:0019883)5.15354735
4positive regulation of gamma-delta T cell activation (GO:0046645)5.06637662
5regulation of B cell receptor signaling pathway (GO:0050855)4.85670428
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72086145
7negative regulation of cell killing (GO:0031342)4.52656163
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52656163
9leukocyte aggregation (GO:0070486)4.35149326
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.20591431
11negative thymic T cell selection (GO:0045060)3.95508548
12negative T cell selection (GO:0043383)3.90777314
13* Arp2/3 complex-mediated actin nucleation (GO:0034314)3.89165576
14positive thymic T cell selection (GO:0045059)3.83958667
15regulation of gamma-delta T cell differentiation (GO:0045586)3.82837376
16detection of molecule of bacterial origin (GO:0032490)3.67621938
17regulation of gamma-delta T cell activation (GO:0046643)3.57633045
18B cell receptor signaling pathway (GO:0050853)3.54557999
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52811853
20detection of other organism (GO:0098543)3.46506288
21regulation of B cell differentiation (GO:0045577)3.43912483
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.42117226
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.42117226
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.42117226
25modulation by symbiont of host immune response (GO:0052553)3.42117226
26positive regulation by symbiont of host defense response (GO:0052509)3.42117226
27modulation by symbiont of host defense response (GO:0052031)3.42117226
28immunoglobulin mediated immune response (GO:0016064)3.40189009
29regulation of interleukin-12 biosynthetic process (GO:0045075)3.37225886
30regulation of interferon-beta biosynthetic process (GO:0045357)3.30023237
31negative regulation of phagocytosis (GO:0050765)3.29422390
32thymic T cell selection (GO:0045061)3.27794465
33protein localization to endosome (GO:0036010)3.26520016
34detection of external biotic stimulus (GO:0098581)3.25905935
35positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.25360856
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.24860026
37neutrophil activation involved in immune response (GO:0002283)3.20417566
38response to interleukin-15 (GO:0070672)3.19785717
39T cell migration (GO:0072678)3.17410215
40leukocyte cell-cell adhesion (GO:0007159)3.15902693
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14809829
42positive regulation of B cell differentiation (GO:0045579)3.12579970
43cellular response to zinc ion (GO:0071294)3.12009806
44hepatocyte apoptotic process (GO:0097284)3.09836485
45detection of bacterium (GO:0016045)3.07733851
46positive T cell selection (GO:0043368)3.05767009
47positive regulation of interferon-alpha production (GO:0032727)3.05633502
48regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.00940475
49cellular extravasation (GO:0045123)3.00781574
50respiratory burst (GO:0045730)2.99969730
51T cell selection (GO:0045058)2.99927395
52antigen processing and presentation via MHC class Ib (GO:0002475)2.98888549
53NIK/NF-kappaB signaling (GO:0038061)2.98223411
54B cell mediated immunity (GO:0019724)2.96996303
55regulation of interferon-alpha production (GO:0032647)2.96134318
56interferon-gamma production (GO:0032609)2.91034870
57JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.89019631
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87694194
59tolerance induction (GO:0002507)2.87424743
60detection of biotic stimulus (GO:0009595)2.86280862
61membrane raft organization (GO:0031579)2.85830639
62pinocytosis (GO:0006907)2.85698022
63* actin nucleation (GO:0045010)2.83199549
64T cell costimulation (GO:0031295)2.82987615
65regulation of tolerance induction (GO:0002643)2.81529394
66interferon-gamma-mediated signaling pathway (GO:0060333)2.81194685
67negative regulation of T cell mediated immunity (GO:0002710)2.79970270
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79425308
69lymphocyte costimulation (GO:0031294)2.78764918
70cellular response to interleukin-15 (GO:0071350)2.78713150
71regulation of T cell tolerance induction (GO:0002664)2.78573884
72germinal center formation (GO:0002467)2.77227175
73negative regulation of interleukin-12 production (GO:0032695)2.76867167
74myeloid dendritic cell activation (GO:0001773)2.73273150
75negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.72321185
76positive regulation of isotype switching (GO:0045830)2.72156915
77neutrophil activation (GO:0042119)2.71403945
78regulation of response to interferon-gamma (GO:0060330)2.69438844
79hypotonic response (GO:0006971)2.68675526
80positive regulation of macrophage differentiation (GO:0045651)2.66249989
81response to host immune response (GO:0052572)2.66123845
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66123845
83regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64611541
84regulation of T cell receptor signaling pathway (GO:0050856)2.63083345
85antigen receptor-mediated signaling pathway (GO:0050851)2.62988780
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.62948236
87regulation of alpha-beta T cell proliferation (GO:0046640)2.62850497
88regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.62678956
89response to peptidoglycan (GO:0032494)2.62326759
90regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.61425600
91* positive regulation of lamellipodium assembly (GO:0010592)2.60919319
92regulation of interleukin-2 biosynthetic process (GO:0045076)2.60480310
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58797356
94response to host (GO:0075136)2.58797356
95response to host defenses (GO:0052200)2.58797356
96production of molecular mediator involved in inflammatory response (GO:0002532)2.58333569
97negative regulation of interleukin-17 production (GO:0032700)2.58085028
98T-helper 1 type immune response (GO:0042088)2.57182261
99regulation of vitamin D biosynthetic process (GO:0060556)2.56949287
100macrophage activation involved in immune response (GO:0002281)2.56397172
101regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55316616
102natural killer cell mediated immunity (GO:0002228)2.54993929
103natural killer cell mediated cytotoxicity (GO:0042267)2.54993929
104negative regulation of B cell proliferation (GO:0030889)2.54772250
105granulocyte activation (GO:0036230)2.54382792
106myeloid dendritic cell differentiation (GO:0043011)2.52540402
107response to muramyl dipeptide (GO:0032495)2.51820391
108regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51284455
109response to protozoan (GO:0001562)2.51242601
110positive regulation of macrophage cytokine production (GO:0060907)2.51193798
111response to type I interferon (GO:0034340)2.48689144
112positive regulation of antigen processing and presentation (GO:0002579)2.47656329
113myeloid cell activation involved in immune response (GO:0002275)2.45825595
114regulation of macrophage cytokine production (GO:0010935)2.45152416
115cellular response to type I interferon (GO:0071357)2.44765601
116type I interferon signaling pathway (GO:0060337)2.44765601
117T cell homeostasis (GO:0043029)2.44732539
118positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44726720
119regulation of mast cell degranulation (GO:0043304)2.44076316
120macrophage activation (GO:0042116)2.44002162
121T cell proliferation (GO:0042098)2.43993681
122positive regulation of interleukin-2 production (GO:0032743)2.43510262
123* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.42755585
124positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42399969
125regulation of isotype switching to IgG isotypes (GO:0048302)2.42360591
126lymphocyte homeostasis (GO:0002260)2.42182617
127mast cell activation (GO:0045576)2.41844747
128T cell receptor signaling pathway (GO:0050852)2.39322449
129natural killer cell differentiation (GO:0001779)2.39000008
130defense response to protozoan (GO:0042832)2.38942511
131regulation of necroptotic process (GO:0060544)2.37747066
132mature B cell differentiation (GO:0002335)2.37186964
133positive regulation of interferon-beta production (GO:0032728)2.37067412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.73286942
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.30004476
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.13603085
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.06189579
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69491377
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.60306802
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20942663
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13252300
9MYC_22102868_ChIP-Seq_BL_Human3.02755734
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.97400993
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.94442681
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89361891
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82576028
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59334015
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.57243930
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56791408
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54131548
18* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50067956
19MYB_26560356_Chip-Seq_TH2_Human2.44573942
20VDR_21846776_ChIP-Seq_THP-1_Human2.44377436
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29202050
22MAF_26560356_Chip-Seq_TH1_Human2.25173749
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.23962308
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23285255
25* SPI1_23547873_ChIP-Seq_NB4_Human2.18022122
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17516547
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11993321
28* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09516166
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.08875789
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07867087
31* MYB_26560356_Chip-Seq_TH1_Human2.05568079
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00445318
33UTX_26944678_Chip-Seq_JUKART_Human1.98679218
34RUNX_20019798_ChIP-Seq_JUKART_Human1.95329835
35* VDR_24763502_ChIP-Seq_THP-1_Human1.89399424
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.86120164
37* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84877990
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83626079
39* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81139778
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.76551936
41SCL_19346495_ChIP-Seq_HPC-7_Human1.67937428
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62741683
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.57858642
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57765574
45* SPI1_23127762_ChIP-Seq_K562_Human1.57362199
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54945907
47* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52144433
48* VDR_24787735_ChIP-Seq_THP-1_Human1.51456674
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51438150
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50774283
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48600979
52* GATA3_27048872_Chip-Seq_THYMUS_Human1.45457645
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43691247
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40929752
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39985844
56* PU_27001747_Chip-Seq_BMDM_Mouse1.39484858
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.38145227
58* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37791452
59* KDM2B_26808549_Chip-Seq_DND41_Human1.33919770
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30381938
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30346835
62* MAF_26560356_Chip-Seq_TH2_Human1.28333936
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.25164452
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24648628
65TFEB_21752829_ChIP-Seq_HELA_Human1.24490007
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24018475
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18564453
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17114960
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.14982660
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13647009
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13627487
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12777625
73CIITA_25753668_ChIP-Seq_RAJI_Human1.12476635
74GATA1_22025678_ChIP-Seq_K562_Human1.10965573
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09869712
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.09712160
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.09705627
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09265202
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09075110
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08090207
81* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06724109
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04296838
83* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03241419
84BRD4_25478319_ChIP-Seq_HGPS_Human1.01661612
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01627449
86* ELK1_19687146_ChIP-ChIP_HELA_Human1.01528278
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01214311
88GATA3_26560356_Chip-Seq_TH2_Human1.00520166
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00133955
90AR_21909140_ChIP-Seq_LNCAP_Human0.99870972
91GATA1_19941826_ChIP-Seq_K562_Human0.97351899
92* VDR_23849224_ChIP-Seq_CD4+_Human0.96843506
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94794956
94NCOR1_26117541_ChIP-Seq_K562_Human0.93832934
95* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91615797
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91544827
97GATA2_19941826_ChIP-Seq_K562_Human0.89475791
98* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89442937
99* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87864111
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87827067
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86921273
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.86573254
103* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86560114
104* ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85771802
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85730937
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83293203
107KDM5A_27292631_Chip-Seq_BREAST_Human0.82948917
108CLOCK_20551151_ChIP-Seq_293T_Human0.82541675
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81924653
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.80882416
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80285777
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80231790
113* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79634424
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79261966
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78920899
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78920899
117* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.78811957
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78341459
119* FOXP3_21729870_ChIP-Seq_TREG_Human0.76692996
120* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75461177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.73807089
2MP0003303_peritoneal_inflammation3.19497609
3MP0000685_abnormal_immune_system2.93185345
4MP0003436_decreased_susceptibility_to2.87363701
5MP0001800_abnormal_humoral_immune2.72140636
6MP0005671_abnormal_response_to2.69848905
7MP0005000_abnormal_immune_tolerance2.61443829
8MP0001790_abnormal_immune_system2.59920277
9MP0005387_immune_system_phenotype2.59920277
10MP0003300_gastrointestinal_ulcer2.59659833
11MP0002452_abnormal_antigen_presenting2.54949999
12MP0009785_altered_susceptibility_to2.52915673
13MP0003763_abnormal_thymus_physiology2.51540233
14MP0010352_gastrointestinal_tract_polyps2.49784922
15MP0002420_abnormal_adaptive_immunity2.38700270
16MP0001819_abnormal_immune_cell2.37313041
17MP0002723_abnormal_immune_serum2.32372585
18MP0002166_altered_tumor_susceptibility2.32194817
19MP0002419_abnormal_innate_immunity2.29098407
20MP0005025_abnormal_response_to2.27831551
21MP0002396_abnormal_hematopoietic_system2.26297731
22MP0002398_abnormal_bone_marrow2.20470856
23MP0002148_abnormal_hypersensitivity_rea2.11653351
24MP0002405_respiratory_system_inflammati2.06850714
25MP0002006_tumorigenesis1.99877884
26MP0000716_abnormal_immune_system1.96662181
27MP0006082_CNS_inflammation1.93572611
28MP0004947_skin_inflammation1.93300763
29MP0009333_abnormal_splenocyte_physiolog1.88971454
30MP0008260_abnormal_autophagy1.84971899
31MP0005464_abnormal_platelet_physiology1.84480616
32MP0004808_abnormal_hematopoietic_stem1.83641168
33MP0010155_abnormal_intestine_physiology1.83588845
34MP0000689_abnormal_spleen_morphology1.79648835
35MP0002722_abnormal_immune_system1.77649402
36MP0001853_heart_inflammation1.74432275
37MP0001873_stomach_inflammation1.74170729
38MP0004510_myositis1.71799090
39MP0005451_abnormal_body_composition1.71005193
40MP0002429_abnormal_blood_cell1.67878987
41MP0005076_abnormal_cell_differentiation1.67532460
42MP0001845_abnormal_inflammatory_respons1.62682216
43MP0003566_abnormal_cell_adhesion1.60463956
44MP0000858_altered_metastatic_potential1.59875512
45MP0006054_spinal_hemorrhage1.59345820
46MP0009278_abnormal_bone_marrow1.57786235
47MP0000703_abnormal_thymus_morphology1.56394087
48MP0005397_hematopoietic_system_phenotyp1.54866742
49MP0001545_abnormal_hematopoietic_system1.54866742
50MP0001533_abnormal_skeleton_physiology1.54170731
51MP0010307_abnormal_tumor_latency1.51492931
52MP0003448_altered_tumor_morphology1.51261390
53MP0003724_increased_susceptibility_to1.51142866
54MP0010234_abnormal_vibrissa_follicle1.47075580
55MP0005058_abnormal_lysosome_morphology1.45902216
56MP0000490_abnormal_crypts_of1.45292465
57MP0003705_abnormal_hypodermis_morpholog1.45286878
58MP0003693_abnormal_embryo_hatching1.43975934
59MP0000465_gastrointestinal_hemorrhage1.42806104
60MP0000569_abnormal_digit_pigmentation1.38731440
61MP0003866_abnormal_defecation1.36230831
62MP0002933_joint_inflammation1.33012491
63MP0003172_abnormal_lysosome_physiology1.25135407
64MP0005310_abnormal_salivary_gland1.24759211
65MP0003656_abnormal_erythrocyte_physiolo1.23610491
66MP0005023_abnormal_wound_healing1.23270031
67MP0003183_abnormal_peptide_metabolism1.22162848
68MP0002877_abnormal_melanocyte_morpholog1.20723039
69MP0004883_abnormal_blood_vessel1.15927209
70MP0005164_abnormal_response_to1.13524302
71MP0003077_abnormal_cell_cycle1.12831137
72MP0002019_abnormal_tumor_incidence1.09958894
73MP0003221_abnormal_cardiomyocyte_apopto1.08830643
74MP0003091_abnormal_cell_migration1.05926548
75MP0010094_abnormal_chromosome_stability1.03044199
76MP0008469_abnormal_protein_level1.01151806
77MP0008057_abnormal_DNA_replication0.98907590
78MP0000343_altered_response_to0.97770649
79MP0009840_abnormal_foam_cell0.97102703
80MP0003111_abnormal_nucleus_morphology0.95389084
81MP0005174_abnormal_tail_pigmentation0.92743104
82* MP0004957_abnormal_blastocyst_morpholog0.92512352
83MP0001851_eye_inflammation0.92336997
84MP0009763_increased_sensitivity_to0.89543863
85MP0002998_abnormal_bone_remodeling0.89161581
86MP0008007_abnormal_cellular_replicative0.89134739
87MP0002009_preneoplasia0.87247769
88MP0003950_abnormal_plasma_membrane0.86915912
89MP0003828_pulmonary_edema0.86692972
90MP0000015_abnormal_ear_pigmentation0.84091154
91MP0003279_aneurysm0.83456763
92MP0003453_abnormal_keratinocyte_physiol0.82375861
93MP0000350_abnormal_cell_proliferation0.81949533
94MP0005275_abnormal_skin_tensile0.81479256
95MP0008004_abnormal_stomach_pH0.80785361
96MP0001958_emphysema0.79279077
97MP0001542_abnormal_bone_strength0.74973224
98MP0001915_intracranial_hemorrhage0.74378882
99MP0005166_decreased_susceptibility_to0.72014546
100MP0008438_abnormal_cutaneous_collagen0.71565509
101MP0005390_skeleton_phenotype0.70746666
102MP0003795_abnormal_bone_structure0.70723076
103MP0000313_abnormal_cell_death0.67715669
104MP0003045_fibrosis0.66952614
105MP0000477_abnormal_intestine_morphology0.66695033
106MP0003191_abnormal_cellular_cholesterol0.65937917
107MP0000249_abnormal_blood_vessel0.65866228
108MP0005621_abnormal_cell_physiology0.65332172
109MP0003075_altered_response_to0.64731007
110* MP0001730_embryonic_growth_arrest0.63551519
111MP0000371_diluted_coat_color0.62988795
112MP0009764_decreased_sensitivity_to0.62671765
113MP0002086_abnormal_extraembryonic_tissu0.61815795
114MP0000604_amyloidosis0.61155698
115MP0001216_abnormal_epidermal_layer0.58957869

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.98587720
2Recurrent abscess formation (HP:0002722)4.73404533
3Recurrent bacterial skin infections (HP:0005406)4.11344754
4Elevated erythrocyte sedimentation rate (HP:0003565)3.83281769
5Myositis (HP:0100614)3.81299036
6Recurrent viral infections (HP:0004429)3.80976293
7Recurrent fungal infections (HP:0002841)3.79330606
8IgM deficiency (HP:0002850)3.38278698
9T lymphocytopenia (HP:0005403)3.38013152
10Chronic otitis media (HP:0000389)3.36529980
11Abnormality of T cell number (HP:0011839)3.29755382
12Recurrent bronchitis (HP:0002837)3.28581241
13Cellulitis (HP:0100658)3.27792279
14Mediastinal lymphadenopathy (HP:0100721)3.24470795
15Abnormality of glycolipid metabolism (HP:0010969)3.17394104
16Abnormality of liposaccharide metabolism (HP:0010968)3.17394104
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.17394104
18Thrombocytosis (HP:0001894)3.12228875
19Abnormality of T cells (HP:0002843)3.06237308
20Recurrent gram-negative bacterial infections (HP:0005420)2.99864256
21Chronic obstructive pulmonary disease (HP:0006510)2.99398204
22Obstructive lung disease (HP:0006536)2.99398204
23Autoimmune thrombocytopenia (HP:0001973)2.95156575
24Orchitis (HP:0100796)2.92335536
25Meningitis (HP:0001287)2.86815653
26Abnormality of macrophages (HP:0004311)2.85861870
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.83240527
28Nasal polyposis (HP:0100582)2.82887704
29Pustule (HP:0200039)2.81712880
30Recurrent skin infections (HP:0001581)2.78714492
31Myocardial infarction (HP:0001658)2.77887388
32Vasculitis (HP:0002633)2.75395540
33Lymphopenia (HP:0001888)2.69242886
34Autoimmune hemolytic anemia (HP:0001890)2.69118610
35Abnormality of T cell physiology (HP:0011840)2.68613588
36Chronic mucocutaneous candidiasis (HP:0002728)2.67332848
37Recurrent cutaneous fungal infections (HP:0011370)2.67332848
38Abnormality of cells of the lymphoid lineage (HP:0012140)2.64933167
39Retrobulbar optic neuritis (HP:0100654)2.64247753
40Optic neuritis (HP:0100653)2.64247753
41Inflammation of the large intestine (HP:0002037)2.60212821
42Interstitial pulmonary disease (HP:0006530)2.58914926
43Gastrointestinal inflammation (HP:0004386)2.57820756
44Panhypogammaglobulinemia (HP:0003139)2.56965278
45Arterial thrombosis (HP:0004420)2.56852377
46Hematochezia (HP:0002573)2.54701693
47Abnormality of the nasal mucosa (HP:0000433)2.54213004
48Stomatitis (HP:0010280)2.52437414
49Urticaria (HP:0001025)2.51144600
50Gingivitis (HP:0000230)2.48608941
51Spontaneous hematomas (HP:0007420)2.46812268
52Increased density of long bones (HP:0006392)2.46621450
53Periodontitis (HP:0000704)2.43880551
54IgA deficiency (HP:0002720)2.42923084
55Increased cerebral lipofuscin (HP:0011813)2.41037168
56Colitis (HP:0002583)2.40347764
57Leukocytosis (HP:0001974)2.40117995
58Increased IgE level (HP:0003212)2.38205230
59Agammaglobulinemia (HP:0004432)2.38093574
60Chest pain (HP:0100749)2.36334220
61Eosinophilia (HP:0001880)2.30624389
62Pulmonary infiltrates (HP:0002113)2.29722530
63IgG deficiency (HP:0004315)2.28992667
64Gingival bleeding (HP:0000225)2.28076480
65Peritonitis (HP:0002586)2.27929169
66Thyroiditis (HP:0100646)2.27697612
67Premature rupture of membranes (HP:0001788)2.27330938
68Osteomyelitis (HP:0002754)2.27112734
69Increased IgM level (HP:0003496)2.25880854
70B lymphocytopenia (HP:0010976)2.25638636
71Abnormality of B cell number (HP:0010975)2.25638636
72Verrucae (HP:0200043)2.23980802
73Papilloma (HP:0012740)2.23980802
74Combined immunodeficiency (HP:0005387)2.22304365
75Spondylolisthesis (HP:0003302)2.22067933
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.18703351
77Osteolytic defects of the hand bones (HP:0009699)2.18703351
78Gastrointestinal stroma tumor (HP:0100723)2.18447770
79Disinhibition (HP:0000734)2.17870009
80Papilledema (HP:0001085)2.17780163
81Epistaxis (HP:0000421)2.17363854
82Severe combined immunodeficiency (HP:0004430)2.14432277
83Emphysema (HP:0002097)2.12612289
84Skin ulcer (HP:0200042)2.12418868
85Glomerulopathy (HP:0100820)2.10203621
86Increased neuronal autofluorescent lipopigment (HP:0002074)2.09929756
87Loss of speech (HP:0002371)2.09631224
88Abnormal platelet volume (HP:0011876)2.07630622
89Keratoconjunctivitis (HP:0001096)2.06628622
90Abnormality of the fingertips (HP:0001211)2.06534641
91Granulocytopenia (HP:0001913)2.05081914
92Vacuolated lymphocytes (HP:0001922)2.03389168
93Amaurosis fugax (HP:0100576)2.02444015
94Hemoptysis (HP:0002105)2.01723473
95Abnormality of the peritoneum (HP:0002585)2.00968262
96Abnormality of eosinophils (HP:0001879)2.00743369
97Cerebral aneurysm (HP:0004944)2.00087977
98Lymphoma (HP:0002665)1.98441929
99Hypergammaglobulinemia (HP:0010702)1.98006682
100Thick nail (HP:0001805)1.95511669
101Keratoconjunctivitis sicca (HP:0001097)1.95398914
102Chronic diarrhea (HP:0002028)1.95198033
103Petechiae (HP:0000967)1.94606389
104Gastrointestinal infarctions (HP:0005244)1.92900394
105Encephalitis (HP:0002383)1.92698782
106Spinal cord lesions (HP:0100561)1.91224350
107Syringomyelia (HP:0003396)1.91224350
108Viral hepatitis (HP:0006562)1.90521109
109Aortic dissection (HP:0002647)1.90481037
110Dysostosis multiplex (HP:0000943)1.89723245
111Increased mean platelet volume (HP:0011877)1.89209167
112Agnosia (HP:0010524)1.88646393
113Hepatosplenomegaly (HP:0001433)1.88513345
114Recurrent lower respiratory tract infections (HP:0002783)1.87427097
115Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85990384
116Fatigue (HP:0012378)1.85605244
117Premature loss of primary teeth (HP:0006323)1.85267846
118Aortic aneurysm (HP:0004942)1.84682513
119Sepsis (HP:0100806)1.84652086
120Cutaneous melanoma (HP:0012056)1.84062591
121Subacute progressive viral hepatitis (HP:0006572)1.83471183
122Recurrent pneumonia (HP:0006532)1.83092112
123Dilatation of the ascending aorta (HP:0005111)1.83038066
124Restrictive lung disease (HP:0002091)1.82777472
125Gangrene (HP:0100758)1.81531224
126Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81050427
127Slow saccadic eye movements (HP:0000514)1.80490315
128Prolonged bleeding time (HP:0003010)1.78797391
129Abnormality of oral frenula (HP:0000190)1.78438892
130Abnormality of the prostate (HP:0008775)1.77386777
131Polycythemia (HP:0001901)1.77208221
132Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76981312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.38450166
2PRPF4B2.77791805
3STK102.77656775
4JAK32.48559174
5BLK2.47145722
6TXK2.46701101
7TYK22.28313459
8ZAP702.25656721
9TRIB32.23231547
10BMPR22.19168671
11PKN22.14803433
12MAP3K141.89184727
13LRRK21.89117047
14TBK11.87499495
15ITK1.86642472
16RPS6KA41.82901822
17ERN11.82104331
18EEF2K1.79932931
19MAP3K101.78316877
20RIPK41.76531727
21TESK21.71242051
22GRK61.70348316
23BTK1.68682391
24IRAK41.68195206
25KIT1.64638798
26SCYL21.63032928
27CSK1.59589955
28JAK11.59346215
29SYK1.52636468
30TEC1.49934980
31PIK3CG1.46824013
32TESK11.44727413
33CSF1R1.43177063
34TTN1.41120356
35IKBKE1.35995660
36SIK31.33449572
37HCK1.32512291
38LCK1.29815464
39MAP3K131.29291986
40FGFR31.28839093
41KDR1.24797502
42NEK21.20832083
43MAP2K31.16513364
44CDC71.15131374
45TAOK21.14551725
46IKBKB1.10497395
47RIPK11.10227959
48MOS1.10177305
49FGFR41.09809039
50MST41.07279366
51MARK31.04070481
52MAP3K81.01847924
53PTK61.01766041
54PIM10.98347588
55NEK90.98072669
56GRK70.95258714
57LYN0.94691614
58TGFBR20.93511561
59PAK40.93171168
60FES0.92698775
61CDK120.92215317
62PDGFRA0.91361046
63CLK10.89946589
64FLT30.89293324
65NME20.87023507
66TRPM70.84239373
67CHUK0.83880646
68CDK60.82669858
69KSR10.82581398
70CAMKK20.82262586
71CDK40.80284032
72ALK0.80277712
73EPHB10.79559224
74MAP3K10.77318894
75MAP3K20.76558492
76JAK20.75229788
77MAP3K60.74630585
78YES10.73066110
79TGFBR10.71284065
80ACVR1B0.71040331
81PIM20.70588773
82STK40.66694264
83MYLK0.64892516
84TAOK30.64210807
85RPS6KB20.61219729
86SIK20.60944985
87DMPK0.60577924
88PRKCQ0.60348778
89IRAK10.58605857
90BRD40.55959936
91DDR20.55273257
92MAP3K30.54693970
93MAP3K110.54561920
94TAOK10.54385935
95RAF10.53437542
96EPHA30.52183204
97SMG10.51948755
98CDC42BPA0.51794673
99EGFR0.50698880
100MATK0.50325884
101PRKCH0.49310634
102MAPKAPK20.48240589
103EIF2AK30.47639877
104PDGFRB0.47455044
105EIF2AK10.45607221
106IRAK20.44067083
107STK30.43692400
108MELK0.43613273
109NLK0.43017301
110ATR0.41942879
111PDK10.41397121
112ABL10.41227780
113IRAK30.41133937
114FRK0.40910453
115MAPK70.40485020
116MAP3K50.39878252
117KSR20.38894191
118PRKG20.38800790
119ILK0.38607762
120STK240.38249525
121FYN0.37661796
122BRSK20.37380306
123MAP3K120.37021079
124MAPK110.36824373
125AURKB0.36390829
126FGR0.36281538

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.80300880
2Leishmaniasis_Homo sapiens_hsa051402.63961374
3Antigen processing and presentation_Homo sapiens_hsa046122.30811028
4B cell receptor signaling pathway_Homo sapiens_hsa046622.29202519
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.09805188
6Osteoclast differentiation_Homo sapiens_hsa043802.08459285
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98489692
8Measles_Homo sapiens_hsa051621.91346063
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88492306
10Shigellosis_Homo sapiens_hsa051311.86771904
11T cell receptor signaling pathway_Homo sapiens_hsa046601.85969511
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.79614629
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77823517
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75790616
15Viral myocarditis_Homo sapiens_hsa054161.68243732
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.64216208
17Legionellosis_Homo sapiens_hsa051341.63897267
18Hematopoietic cell lineage_Homo sapiens_hsa046401.62707762
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61403399
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60863662
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60731462
22Toxoplasmosis_Homo sapiens_hsa051451.54983420
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49511637
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47537781
25Tuberculosis_Homo sapiens_hsa051521.46874395
26Graft-versus-host disease_Homo sapiens_hsa053321.45974629
27Herpes simplex infection_Homo sapiens_hsa051681.44286987
28DNA replication_Homo sapiens_hsa030301.43242580
29Allograft rejection_Homo sapiens_hsa053301.41772665
30Apoptosis_Homo sapiens_hsa042101.39169718
31Pertussis_Homo sapiens_hsa051331.36102923
32Hepatitis B_Homo sapiens_hsa051611.36013050
33Chronic myeloid leukemia_Homo sapiens_hsa052201.34100942
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33630589
35Salmonella infection_Homo sapiens_hsa051321.33374892
36TNF signaling pathway_Homo sapiens_hsa046681.33082158
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32104554
38Chemokine signaling pathway_Homo sapiens_hsa040621.29376722
39Influenza A_Homo sapiens_hsa051641.27165017
40Pancreatic cancer_Homo sapiens_hsa052121.24807882
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.24723702
42Malaria_Homo sapiens_hsa051441.18464000
43Platelet activation_Homo sapiens_hsa046111.14847998
44Acute myeloid leukemia_Homo sapiens_hsa052211.14413800
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09954852
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09091935
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08799243
48Asthma_Homo sapiens_hsa053101.06494541
49Viral carcinogenesis_Homo sapiens_hsa052031.05793012
50Epstein-Barr virus infection_Homo sapiens_hsa051691.03319520
51VEGF signaling pathway_Homo sapiens_hsa043701.02811839
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.02743127
53Staphylococcus aureus infection_Homo sapiens_hsa051501.02344191
54Small cell lung cancer_Homo sapiens_hsa052221.02088975
55HTLV-I infection_Homo sapiens_hsa051661.01368803
56p53 signaling pathway_Homo sapiens_hsa041151.00073000
57Lysosome_Homo sapiens_hsa041420.94474161
58Cell cycle_Homo sapiens_hsa041100.90742319
59Colorectal cancer_Homo sapiens_hsa052100.88446531
60Base excision repair_Homo sapiens_hsa034100.88319094
61Bladder cancer_Homo sapiens_hsa052190.86565564
62Mismatch repair_Homo sapiens_hsa034300.86394512
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.85432683
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84791275
65Non-small cell lung cancer_Homo sapiens_hsa052230.82324815
66African trypanosomiasis_Homo sapiens_hsa051430.82055417
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78051995
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77857753
69Other glycan degradation_Homo sapiens_hsa005110.77270402
70Hepatitis C_Homo sapiens_hsa051600.76702808
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76284388
72Proteoglycans in cancer_Homo sapiens_hsa052050.75950919
73Phagosome_Homo sapiens_hsa041450.75550182
74MicroRNAs in cancer_Homo sapiens_hsa052060.75047558
75Adherens junction_Homo sapiens_hsa045200.74144985
76Autoimmune thyroid disease_Homo sapiens_hsa053200.73595524
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73129336
78Type I diabetes mellitus_Homo sapiens_hsa049400.71680261
79Prolactin signaling pathway_Homo sapiens_hsa049170.69998174
80Endocytosis_Homo sapiens_hsa041440.69131791
81mTOR signaling pathway_Homo sapiens_hsa041500.66677468
82Focal adhesion_Homo sapiens_hsa045100.64503227
83Thyroid cancer_Homo sapiens_hsa052160.64221598
84Spliceosome_Homo sapiens_hsa030400.62571702
85Amoebiasis_Homo sapiens_hsa051460.62545478
86HIF-1 signaling pathway_Homo sapiens_hsa040660.62306977
87RNA transport_Homo sapiens_hsa030130.59544450
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.58367962
89Non-homologous end-joining_Homo sapiens_hsa034500.56125759
90Renal cell carcinoma_Homo sapiens_hsa052110.50703812
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49150526
92Endometrial cancer_Homo sapiens_hsa052130.47678803
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47455472
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.46909457
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45167136
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43628177
97Glioma_Homo sapiens_hsa052140.43515265
98FoxO signaling pathway_Homo sapiens_hsa040680.43297538
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43250262
100Rheumatoid arthritis_Homo sapiens_hsa053230.43214827
101Prostate cancer_Homo sapiens_hsa052150.42292595
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41323173
103Insulin resistance_Homo sapiens_hsa049310.39488964
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38721172
105N-Glycan biosynthesis_Homo sapiens_hsa005100.38602993
106Homologous recombination_Homo sapiens_hsa034400.38363810
107Renin-angiotensin system_Homo sapiens_hsa046140.37530845
108Pathways in cancer_Homo sapiens_hsa052000.37153978
109Systemic lupus erythematosus_Homo sapiens_hsa053220.37109766
110Dorso-ventral axis formation_Homo sapiens_hsa043200.34446312
111GnRH signaling pathway_Homo sapiens_hsa049120.31751520
112ErbB signaling pathway_Homo sapiens_hsa040120.31626538
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.31019041
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30656618
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30175078
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.30008315

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