ACTR3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.79415869
2synaptic vesicle exocytosis (GO:0016079)5.39896170
3synaptic vesicle maturation (GO:0016188)5.35240048
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.23506891
5vocalization behavior (GO:0071625)5.21957286
6locomotory exploration behavior (GO:0035641)5.16989246
7glutamate secretion (GO:0014047)5.08778711
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08508858
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.05380855
10protein localization to synapse (GO:0035418)4.83138846
11regulation of synaptic vesicle exocytosis (GO:2000300)4.82256619
12regulation of glutamate receptor signaling pathway (GO:1900449)4.71029275
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.64521454
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.56196529
15neuronal action potential propagation (GO:0019227)4.47993200
16exploration behavior (GO:0035640)4.41544004
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39121344
18regulation of synaptic vesicle transport (GO:1902803)4.38625167
19regulation of neuronal synaptic plasticity (GO:0048168)4.36227262
20neuron cell-cell adhesion (GO:0007158)4.35671737
21behavioral response to nicotine (GO:0035095)4.34083116
22glutamate receptor signaling pathway (GO:0007215)4.28217474
23regulation of synapse structural plasticity (GO:0051823)4.20472155
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17180898
25synaptic transmission, glutamatergic (GO:0035249)4.09213999
26neurotransmitter-gated ion channel clustering (GO:0072578)4.04787486
27positive regulation of synapse maturation (GO:0090129)4.03726629
28neurotransmitter secretion (GO:0007269)4.01228118
29neuron-neuron synaptic transmission (GO:0007270)3.97189803
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.84396241
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84047126
32layer formation in cerebral cortex (GO:0021819)3.81068555
33regulation of dendritic spine morphogenesis (GO:0061001)3.77966796
34cellular potassium ion homeostasis (GO:0030007)3.72331162
35regulation of synaptic plasticity (GO:0048167)3.71499659
36long-term memory (GO:0007616)3.66796820
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65806976
38neuron recognition (GO:0008038)3.65743776
39regulation of postsynaptic membrane potential (GO:0060078)3.62318594
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.55519730
41dendritic spine morphogenesis (GO:0060997)3.53699374
42synaptic vesicle endocytosis (GO:0048488)3.52598858
43long-term synaptic potentiation (GO:0060291)3.52213021
44positive regulation of membrane potential (GO:0045838)3.51495535
45G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.50921651
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.49789553
47cell communication by electrical coupling (GO:0010644)3.48537639
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.46490199
49proline transport (GO:0015824)3.46411875
50positive regulation of neurotransmitter secretion (GO:0001956)3.45680557
51behavioral defense response (GO:0002209)3.44861571
52behavioral fear response (GO:0001662)3.44861571
53activation of protein kinase A activity (GO:0034199)3.37483961
54regulation of neurotransmitter secretion (GO:0046928)3.31625774
55axonal fasciculation (GO:0007413)3.30389303
56transmission of nerve impulse (GO:0019226)3.27502684
57innervation (GO:0060384)3.26875734
58fear response (GO:0042596)3.25327746
59vesicle transport along microtubule (GO:0047496)3.24532053
60regulation of vesicle fusion (GO:0031338)3.23931917
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.23671224
62positive regulation of neurotransmitter transport (GO:0051590)3.23659828
63neurotransmitter transport (GO:0006836)3.23567241
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22175712
65neuromuscular process controlling balance (GO:0050885)3.18921998
66postsynaptic membrane organization (GO:0001941)3.18741661
67sodium ion export (GO:0071436)3.18740386
68regulation of dendritic spine development (GO:0060998)3.18069436
69dendritic spine organization (GO:0097061)3.17307128
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.17027667
71gamma-aminobutyric acid transport (GO:0015812)3.16576994
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16367219
73membrane depolarization during action potential (GO:0086010)3.15305926
74detection of calcium ion (GO:0005513)3.14300453
75regulation of glutamate secretion (GO:0014048)3.13999885
76membrane depolarization (GO:0051899)3.13096689
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12839830
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12753382
79negative regulation of dendrite morphogenesis (GO:0050774)3.12646565
80regulation of synapse maturation (GO:0090128)3.10545853
81regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.09164995
82positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08178838
83positive regulation of dendritic spine development (GO:0060999)3.07670580
84presynaptic membrane organization (GO:0097090)3.06181745
85cell migration in hindbrain (GO:0021535)3.05972572
86presynaptic membrane assembly (GO:0097105)3.05162889
87learning (GO:0007612)3.05155374
88negative regulation of dendrite development (GO:2000171)3.05023015
89regulation of neurotransmitter transport (GO:0051588)3.02881668
90long term synaptic depression (GO:0060292)3.00121208
91regulation of neurotransmitter levels (GO:0001505)2.99880933
92primary amino compound metabolic process (GO:1901160)2.99343416
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98779375
94organelle transport along microtubule (GO:0072384)2.97637625
95regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.97617146
96response to histamine (GO:0034776)2.97405459
97protein polyglutamylation (GO:0018095)2.96450665
98water-soluble vitamin biosynthetic process (GO:0042364)2.95684192
99regulation of synaptic transmission (GO:0050804)2.95467117
100regulation of voltage-gated calcium channel activity (GO:1901385)2.95034050
101synaptic transmission (GO:0007268)2.94670883
102behavioral response to cocaine (GO:0048148)2.94497055
103positive regulation of potassium ion transmembrane transport (GO:1901381)2.91545219
104regulation of female receptivity (GO:0045924)2.91206330
105positive regulation of synaptic transmission (GO:0050806)2.90954787
106retinal cone cell development (GO:0046549)2.89613597
107nonmotile primary cilium assembly (GO:0035058)2.88130915
108piRNA metabolic process (GO:0034587)2.81417503
109detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79447667
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76739092
111DNA double-strand break processing (GO:0000729)2.76054505
112neuromuscular synaptic transmission (GO:0007274)2.74347112
113somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73924986
114somatic hypermutation of immunoglobulin genes (GO:0016446)2.73924986
115pyrimidine nucleobase catabolic process (GO:0006208)2.70868606
116serotonin metabolic process (GO:0042428)2.70850991
117protein neddylation (GO:0045116)2.70364689
118regulation of neurotransmitter uptake (GO:0051580)2.68969274
119protein-cofactor linkage (GO:0018065)2.67813184
120synapsis (GO:0007129)2.63035574
121C4-dicarboxylate transport (GO:0015740)2.55527316
122cochlea development (GO:0090102)2.53621637
123regulation of meiosis I (GO:0060631)2.52493081
124replication fork processing (GO:0031297)2.51502700
125reciprocal DNA recombination (GO:0035825)2.49745821
126reciprocal meiotic recombination (GO:0007131)2.49745821
127behavioral response to ethanol (GO:0048149)2.49640640
128negative regulation of DNA-dependent DNA replication (GO:2000104)2.48559606
129nucleobase catabolic process (GO:0046113)2.48478319
130startle response (GO:0001964)2.42409574
131regulation of calcium ion-dependent exocytosis (GO:0017158)2.41238109
132negative regulation of response to food (GO:0032096)2.40661960
133negative regulation of appetite (GO:0032099)2.40661960
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38643667
135DNA methylation involved in gamete generation (GO:0043046)2.37875780
136protein K11-linked deubiquitination (GO:0035871)2.37604899
137L-serine metabolic process (GO:0006563)2.36802588
138positive regulation of meiosis (GO:0045836)2.35885084
139tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.34287357
140RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.34287357
141mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.34247283
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.34247283
143NADH dehydrogenase complex assembly (GO:0010257)2.34247283
144male meiosis (GO:0007140)2.32500829
145indole-containing compound metabolic process (GO:0042430)2.32379986
146regulation of posttranscriptional gene silencing (GO:0060147)2.31710191
147regulation of gene silencing by miRNA (GO:0060964)2.31710191
148regulation of gene silencing by RNA (GO:0060966)2.31710191
149regulation of cilium movement (GO:0003352)2.27720503
150neuronal action potential (GO:0019228)2.26982558
151regulation of nuclear cell cycle DNA replication (GO:0033262)2.26511106
152phosphorelay signal transduction system (GO:0000160)2.25496747
153amino acid salvage (GO:0043102)2.24860155
154L-methionine salvage (GO:0071267)2.24860155
155L-methionine biosynthetic process (GO:0071265)2.24860155
156neurotransmitter uptake (GO:0001504)2.24504102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.39200379
2GBX2_23144817_ChIP-Seq_PC3_Human3.73853581
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.29286161
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19673144
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15533437
6REST_21632747_ChIP-Seq_MESCs_Mouse2.92504093
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.87838128
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80093494
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80093494
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77804766
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74549498
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72991975
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70471184
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58970403
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.55431517
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54859776
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54739272
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52654629
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.38922858
20DROSHA_22980978_ChIP-Seq_HELA_Human2.36864005
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.24929521
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23178308
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.23151286
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.22954957
25* EWS_26573619_Chip-Seq_HEK293_Human2.12857671
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00360741
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97841356
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97798437
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89845243
30AR_21572438_ChIP-Seq_LNCaP_Human1.89144365
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87928021
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87864132
33TAF15_26573619_Chip-Seq_HEK293_Human1.84186044
34* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81941681
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81159219
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80998452
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77589754
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.75676361
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.73653389
40* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72577084
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.67921025
42IRF1_19129219_ChIP-ChIP_H3396_Human1.65861836
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56584385
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.53493760
45ZNF274_21170338_ChIP-Seq_K562_Hela1.51566247
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47035952
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45495786
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44308077
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43953279
50* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42295827
51P300_19829295_ChIP-Seq_ESCs_Human1.41915643
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41788183
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41788183
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41435884
55ER_23166858_ChIP-Seq_MCF-7_Human1.39287441
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38116539
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37486276
58* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37363425
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37137317
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36418181
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.35048798
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34723135
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34433543
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.32842748
65TP53_22573176_ChIP-Seq_HFKS_Human1.32095414
66AR_25329375_ChIP-Seq_VCAP_Human1.30533087
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.30432562
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29641943
69CBP_20019798_ChIP-Seq_JUKART_Human1.29641943
70MYC_18940864_ChIP-ChIP_HL60_Human1.27686043
71* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26877123
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26427802
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25755671
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22651018
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20874232
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19659371
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.19160902
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18497938
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17615676
80AR_19668381_ChIP-Seq_PC3_Human1.16551426
81VDR_22108803_ChIP-Seq_LS180_Human1.16516761
82* STAT3_23295773_ChIP-Seq_U87_Human1.16028629
83* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15649077
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.15223992
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15030290
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14826688
87* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14527863
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.13748385
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12928582
90* BCAT_22108803_ChIP-Seq_LS180_Human1.11389763
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.11049895
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.10504116
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10412128
94* TCF4_22108803_ChIP-Seq_LS180_Human1.08691176
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08181202
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07095120
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06945531
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06559951
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.05593636
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04986247
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.04717186
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.04314151
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.03852331
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.03063902
105LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02422921
106* TCF4_23295773_ChIP-Seq_U87_Human1.02208388
107* NANOG_19829295_ChIP-Seq_ESCs_Human1.01545014
108* SOX2_19829295_ChIP-Seq_ESCs_Human1.01545014
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01461033
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01303272
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01104673
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00981828
113IGF1R_20145208_ChIP-Seq_DFB_Human1.00835312
114JUN_21703547_ChIP-Seq_K562_Human1.00561203
115RNF2_27304074_Chip-Seq_NSC_Mouse0.99246611
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.98554978
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97859812
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.97193556
119* FUS_26573619_Chip-Seq_HEK293_Human0.96919893
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.96097213
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95892579
122RUNX2_22187159_ChIP-Seq_PCA_Human0.95268541
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93930397
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93812299
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93424429
126KDM2B_26808549_Chip-Seq_K562_Human0.93423174
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.93134607
128AHR_22903824_ChIP-Seq_MCF-7_Human0.93083029
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92384977
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.92222909
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92057956
132FOXA1_25329375_ChIP-Seq_VCAP_Human0.91712875
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91712875
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.91041262
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90830968
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90210959
137* NCOR_22424771_ChIP-Seq_293T_Human0.90042025
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.90005529
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88432038
140CTCF_27219007_Chip-Seq_Bcells_Human0.88384777
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87353273
142TP53_16413492_ChIP-PET_HCT116_Human0.87230699
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84515264
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84417975
145TP53_18474530_ChIP-ChIP_U2OS_Human0.83905937
146* TET1_21490601_ChIP-Seq_MESCs_Mouse0.82977219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.62580495
2MP0003880_abnormal_central_pattern5.08085316
3MP0003635_abnormal_synaptic_transmissio4.10331682
4MP0004270_analgesia3.90904645
5MP0002063_abnormal_learning/memory/cond3.38344514
6MP0009745_abnormal_behavioral_response3.36165019
7MP0001968_abnormal_touch/_nociception3.08696785
8MP0002064_seizures2.99084726
9MP0002822_catalepsy2.81448711
10MP0008877_abnormal_DNA_methylation2.81445697
11MP0002572_abnormal_emotion/affect_behav2.75090521
12MP0002735_abnormal_chemical_nociception2.75014244
13MP0009046_muscle_twitch2.66422006
14MP0002736_abnormal_nociception_after2.60711428
15MP0002734_abnormal_mechanical_nocicepti2.58305240
16MP0002272_abnormal_nervous_system2.50430070
17MP0001486_abnormal_startle_reflex2.35888301
18MP0001440_abnormal_grooming_behavior2.24324222
19MP0005423_abnormal_somatic_nervous2.23673843
20MP0002733_abnormal_thermal_nociception2.11978082
21MP0001501_abnormal_sleep_pattern2.06697490
22MP0001970_abnormal_pain_threshold2.03372122
23MP0002102_abnormal_ear_morphology2.00993139
24MP0003329_amyloid_beta_deposits1.98019190
25MP0002067_abnormal_sensory_capabilities1.91928149
26MP0004858_abnormal_nervous_system1.91698253
27MP0009780_abnormal_chondrocyte_physiolo1.88396589
28MP0002184_abnormal_innervation1.84492237
29MP0002837_dystrophic_cardiac_calcinosis1.80853780
30MP0003136_yellow_coat_color1.80067602
31MP0000778_abnormal_nervous_system1.77288445
32MP0006276_abnormal_autonomic_nervous1.75305611
33MP0000751_myopathy1.74654692
34MP0004811_abnormal_neuron_physiology1.70896490
35MP0004924_abnormal_behavior1.70134539
36MP0005386_behavior/neurological_phenoty1.70134539
37MP0008569_lethality_at_weaning1.66231295
38MP0002909_abnormal_adrenal_gland1.66202112
39MP0001984_abnormal_olfaction1.65787935
40MP0002557_abnormal_social/conspecific_i1.63668533
41MP0004147_increased_porphyrin_level1.56495330
42MP0001529_abnormal_vocalization1.54690992
43MP0003879_abnormal_hair_cell1.50353300
44MP0005646_abnormal_pituitary_gland1.49782403
45MP0000955_abnormal_spinal_cord1.48946855
46MP0006072_abnormal_retinal_apoptosis1.45533359
47MP0002653_abnormal_ependyma_morphology1.42452464
48MP0002066_abnormal_motor_capabilities/c1.36376165
49MP0002882_abnormal_neuron_morphology1.35904818
50MP0003195_calcinosis1.35650140
51MP0008058_abnormal_DNA_repair1.35359362
52MP0005253_abnormal_eye_physiology1.33908479
53MP0004215_abnormal_myocardial_fiber1.32068315
54MP0001188_hyperpigmentation1.23336047
55MP0003633_abnormal_nervous_system1.22900884
56MP0004885_abnormal_endolymph1.22712463
57MP0001905_abnormal_dopamine_level1.22617176
58MP0002160_abnormal_reproductive_system1.21210326
59MP0003718_maternal_effect1.21198204
60MP0004142_abnormal_muscle_tone1.19988707
61MP0004145_abnormal_muscle_electrophysio1.18398103
62MP0003121_genomic_imprinting1.16626060
63MP0003787_abnormal_imprinting1.16338326
64MP0003646_muscle_fatigue1.14391043
65MP0001502_abnormal_circadian_rhythm1.13525152
66MP0010094_abnormal_chromosome_stability1.10752738
67MP0004133_heterotaxia1.08423970
68MP0004484_altered_response_of1.07635257
69MP0003890_abnormal_embryonic-extraembry1.07228309
70MP0004085_abnormal_heartbeat1.07047641
71MP0008789_abnormal_olfactory_epithelium1.06814968
72MP0004043_abnormal_pH_regulation1.04528329
73MP0002152_abnormal_brain_morphology1.04253806
74MP0003631_nervous_system_phenotype1.03554354
75MP0005645_abnormal_hypothalamus_physiol1.03446192
76MP0003698_abnormal_male_reproductive1.02891333
77MP0004233_abnormal_muscle_weight1.01809785
78MP0002938_white_spotting0.99091157
79MP0003137_abnormal_impulse_conducting0.96743177
80MP0002210_abnormal_sex_determination0.92032861
81MP0003119_abnormal_digestive_system0.91483244
82MP0000372_irregular_coat_pigmentation0.90740380
83MP0002229_neurodegeneration0.89716758
84MP0005410_abnormal_fertilization0.89662154
85MP0006035_abnormal_mitochondrial_morpho0.89574212
86MP0001293_anophthalmia0.89246519
87MP0000026_abnormal_inner_ear0.88154354
88MP0001986_abnormal_taste_sensitivity0.87260299
89MP0008872_abnormal_physiological_respon0.86806174
90MP0003937_abnormal_limbs/digits/tail_de0.86683081
91MP0005389_reproductive_system_phenotype0.86050050
92MP0000647_abnormal_sebaceous_gland0.85852213
93MP0008874_decreased_physiological_sensi0.85713294
94MP0001929_abnormal_gametogenesis0.85232068
95MP0002069_abnormal_eating/drinking_beha0.84121248
96MP0000569_abnormal_digit_pigmentation0.83149893
97MP0005535_abnormal_body_temperature0.82473409
98MP0000604_amyloidosis0.82101937
99MP0000049_abnormal_middle_ear0.82060706
100MP0004510_myositis0.81725546
101MP0005394_taste/olfaction_phenotype0.81494688
102MP0005499_abnormal_olfactory_system0.81494688
103MP0003938_abnormal_ear_development0.78562221
104MP0004036_abnormal_muscle_relaxation0.78396118
105MP0001485_abnormal_pinna_reflex0.78075153
106MP0005551_abnormal_eye_electrophysiolog0.77739106
107MP0001963_abnormal_hearing_physiology0.76316420
108MP0003634_abnormal_glial_cell0.75239054
109MP0002752_abnormal_somatic_nervous0.75127891
110MP0003122_maternal_imprinting0.74772468
111MP0010386_abnormal_urinary_bladder0.74389339
112MP0005620_abnormal_muscle_contractility0.73907973
113MP0000013_abnormal_adipose_tissue0.73784588
114MP0003075_altered_response_to0.73253257
115MP0005409_darkened_coat_color0.72121950
116MP0004742_abnormal_vestibular_system0.68682435
117MP0008961_abnormal_basal_metabolism0.67141787
118MP0000749_muscle_degeneration0.66889577
119MP0003283_abnormal_digestive_organ0.65820397
120MP0003632_abnormal_nervous_system0.64775867
121MP0002234_abnormal_pharynx_morphology0.63966254
122MP0004084_abnormal_cardiac_muscle0.63962838
123MP0001177_atelectasis0.63749757
124MP0000631_abnormal_neuroendocrine_gland0.63348237
125MP0002972_abnormal_cardiac_muscle0.62447909
126MP0005187_abnormal_penis_morphology0.62080320
127MP0004130_abnormal_muscle_cell0.60684714
128MP0002876_abnormal_thyroid_physiology0.58256327
129MP0000747_muscle_weakness0.58105658
130MP0001664_abnormal_digestion0.57723571
131MP0006292_abnormal_olfactory_placode0.56058795
132MP0003861_abnormal_nervous_system0.54800765
133MP0002638_abnormal_pupillary_reflex0.52336539
134MP0002090_abnormal_vision0.52070846

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.68706354
2Myokymia (HP:0002411)7.08593015
3Focal seizures (HP:0007359)5.60439620
4Visual hallucinations (HP:0002367)5.38300228
5Epileptic encephalopathy (HP:0200134)4.93204499
6Atonic seizures (HP:0010819)4.81056317
7Febrile seizures (HP:0002373)4.35739147
8Absence seizures (HP:0002121)4.32856407
9Progressive cerebellar ataxia (HP:0002073)3.94670266
10Dialeptic seizures (HP:0011146)3.94264581
11Generalized tonic-clonic seizures (HP:0002069)3.77164522
12Hyperventilation (HP:0002883)3.61741455
13Action tremor (HP:0002345)3.50511514
14Supranuclear gaze palsy (HP:0000605)3.38991875
15Poor eye contact (HP:0000817)3.35313494
16Broad-based gait (HP:0002136)3.32091369
17Pancreatic fibrosis (HP:0100732)3.27549147
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.22656166
19Abnormality of alanine metabolism (HP:0010916)3.22656166
20Hyperalaninemia (HP:0003348)3.22656166
21Amblyopia (HP:0000646)3.18777228
22True hermaphroditism (HP:0010459)3.14003117
23Pancreatic cysts (HP:0001737)3.10709705
24Impaired vibration sensation in the lower limbs (HP:0002166)3.06576499
25Abnormality of the labia minora (HP:0012880)3.05797845
26Impaired social interactions (HP:0000735)3.00075917
27Abnormal social behavior (HP:0012433)3.00075917
28Anxiety (HP:0000739)2.99745389
29Depression (HP:0000716)2.99252442
30Gaze-evoked nystagmus (HP:0000640)2.97819221
31Hyperglycinemia (HP:0002154)2.97042922
32Abnormality of midbrain morphology (HP:0002418)2.93775434
33Molar tooth sign on MRI (HP:0002419)2.93775434
34Ankle clonus (HP:0011448)2.92877766
35Dysdiadochokinesis (HP:0002075)2.92211755
36Cerebral inclusion bodies (HP:0100314)2.86480002
37Urinary bladder sphincter dysfunction (HP:0002839)2.85675322
38Dysmetria (HP:0001310)2.81399679
39Medial flaring of the eyebrow (HP:0010747)2.80272529
40Truncal ataxia (HP:0002078)2.75877205
41Abnormality of the lower motor neuron (HP:0002366)2.70921428
42Epileptiform EEG discharges (HP:0011182)2.68775340
43Progressive inability to walk (HP:0002505)2.60441383
44Postural instability (HP:0002172)2.59167243
45Pheochromocytoma (HP:0002666)2.58899431
46Nephronophthisis (HP:0000090)2.58167838
47Excessive salivation (HP:0003781)2.57823034
48Drooling (HP:0002307)2.57823034
49Urinary urgency (HP:0000012)2.56779869
50Abnormal eating behavior (HP:0100738)2.55784833
51EEG with generalized epileptiform discharges (HP:0011198)2.49983236
52Insidious onset (HP:0003587)2.49538968
53Termporal pattern (HP:0011008)2.49538968
54Congenital primary aphakia (HP:0007707)2.49099175
55Mutism (HP:0002300)2.46628235
56Sudden death (HP:0001699)2.46341964
57Neurofibrillary tangles (HP:0002185)2.45719365
58Nephrogenic diabetes insipidus (HP:0009806)2.44041630
59Ventricular fibrillation (HP:0001663)2.43416977
60Congenital stationary night blindness (HP:0007642)2.42651014
61Thyroid-stimulating hormone excess (HP:0002925)2.37240606
62Bradykinesia (HP:0002067)2.36900862
63Lissencephaly (HP:0001339)2.35633680
64Hypsarrhythmia (HP:0002521)2.34964638
65Impaired smooth pursuit (HP:0007772)2.34652779
66Abnormality of binocular vision (HP:0011514)2.32515801
67Diplopia (HP:0000651)2.32515801
68Delusions (HP:0000746)2.30123865
69Hemiparesis (HP:0001269)2.28561112
70Genetic anticipation (HP:0003743)2.28402844
71Megalencephaly (HP:0001355)2.28132798
72Stereotypic behavior (HP:0000733)2.27543847
73Fetal akinesia sequence (HP:0001989)2.26437036
74Inability to walk (HP:0002540)2.26283253
75Dysmetric saccades (HP:0000641)2.23590466
76Torticollis (HP:0000473)2.22265851
77Decreased central vision (HP:0007663)2.22195130
78Abolished electroretinogram (ERG) (HP:0000550)2.21860794
79Pendular nystagmus (HP:0012043)2.21668737
80Abnormality of serine family amino acid metabolism (HP:0010894)2.21436984
81Abnormality of glycine metabolism (HP:0010895)2.21436984
82Neuroendocrine neoplasm (HP:0100634)2.21212783
83Spastic gait (HP:0002064)2.19971223
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.19929080
85Scanning speech (HP:0002168)2.19166836
86Focal dystonia (HP:0004373)2.19111185
87Hyperglycinuria (HP:0003108)2.18339594
88Genital tract atresia (HP:0001827)2.18276257
89Amyotrophic lateral sclerosis (HP:0007354)2.17274427
90Papilledema (HP:0001085)2.16397630
91Status epilepticus (HP:0002133)2.16165468
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.15672542
93Absent speech (HP:0001344)2.14856976
94Annular pancreas (HP:0001734)2.14685705
95Sclerocornea (HP:0000647)2.14147316
96Impaired vibratory sensation (HP:0002495)2.11758470
97Syncope (HP:0001279)2.10202582
98Bundle branch block (HP:0011710)2.09602966
99Vaginal atresia (HP:0000148)2.09297373
100Methylmalonic acidemia (HP:0002912)2.08565474
101Rapidly progressive (HP:0003678)2.07843053
102Abnormality of serum amino acid levels (HP:0003112)2.07143186
103Cystic liver disease (HP:0006706)2.05438622
104Abnormality of the renal medulla (HP:0100957)2.02282932
105Optic nerve hypoplasia (HP:0000609)2.00602963
106Abnormality of the corticospinal tract (HP:0002492)2.00080645
107Type II lissencephaly (HP:0007260)1.99236668
108Lower limb muscle weakness (HP:0007340)1.99016981
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96794071
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.96375483
111Anencephaly (HP:0002323)1.96261588
112Attenuation of retinal blood vessels (HP:0007843)1.95205093
113Generalized myoclonic seizures (HP:0002123)1.94890862
114Poor coordination (HP:0002370)1.94763359
115Abnormal EKG (HP:0003115)1.94636829
116Colon cancer (HP:0003003)1.93037525
117Postaxial foot polydactyly (HP:0001830)1.92649636
118Exercise-induced myalgia (HP:0003738)1.92108393
119Craniofacial dystonia (HP:0012179)1.91688885
120Athetosis (HP:0002305)1.90999967
121Psychosis (HP:0000709)1.90851376
122Abnormality of ocular smooth pursuit (HP:0000617)1.90721567
123Specific learning disability (HP:0001328)1.89248417
124Incomplete penetrance (HP:0003829)1.88361898
125Intestinal atresia (HP:0011100)1.86518950
126Short tibia (HP:0005736)1.85284099
127Limb dystonia (HP:0002451)1.84574662
128Preaxial hand polydactyly (HP:0001177)1.83587349
129Birth length less than 3rd percentile (HP:0003561)1.82821778
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.81190750
131Thickened helices (HP:0000391)1.81087929
132Dyskinesia (HP:0100660)1.80949998
133Postaxial hand polydactyly (HP:0001162)1.80541359
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80522457
135Hypoplasia of the brainstem (HP:0002365)1.80522457
136Polyphagia (HP:0002591)1.80095415
137Retinal dysplasia (HP:0007973)1.79470489
138Lower limb asymmetry (HP:0100559)1.79274638
139Myotonia (HP:0002486)1.78864070
140Neoplasm of the peripheral nervous system (HP:0100007)1.78093710
141Gait imbalance (HP:0002141)1.78049446
142Intention tremor (HP:0002080)1.77603947
143Primary atrial arrhythmia (HP:0001692)1.77448083
144Gait ataxia (HP:0002066)1.76972880
145Chronic hepatic failure (HP:0100626)1.76331462
146Lower limb amyotrophy (HP:0007210)1.76135725
147Abnormality of the ileum (HP:0001549)1.75956834
148Hydroureter (HP:0000072)1.75310537
149Shoulder girdle muscle weakness (HP:0003547)1.73601667
150Abnormality of pain sensation (HP:0010832)1.73417772
151Impaired pain sensation (HP:0007328)1.73417772
152Meckel diverticulum (HP:0002245)1.68325274
153Pachygyria (HP:0001302)1.68143363
154Septo-optic dysplasia (HP:0100842)1.67540403
155Acute encephalopathy (HP:0006846)1.66768619
156Abnormal rod and cone electroretinograms (HP:0008323)1.65493067
157Oligodactyly (hands) (HP:0001180)1.64738063
158Broad foot (HP:0001769)1.64420394
159Abnormality of the renal cortex (HP:0011035)1.64025541
160Methylmalonic aciduria (HP:0012120)1.63080329
161Polydipsia (HP:0001959)1.61865530
162Abnormal drinking behavior (HP:0030082)1.61865530
163Cerebral hypomyelination (HP:0006808)1.61462800
164Supernumerary spleens (HP:0009799)1.60959394
165Sloping forehead (HP:0000340)1.60545272
166Male pseudohermaphroditism (HP:0000037)1.59899285
167Astigmatism (HP:0000483)1.59260216
168Large for gestational age (HP:0001520)1.58849551
169Acute necrotizing encephalopathy (HP:0006965)1.58542399
1703-Methylglutaconic aciduria (HP:0003535)1.57915327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.26429954
2NTRK34.35514619
3MAP3K93.84808260
4FRK3.65656984
5MINK12.81295170
6MAP3K42.78090125
7MARK12.61860185
8KSR22.51425306
9DAPK22.41044202
10RIPK42.37960245
11MAP2K72.36049288
12MAP4K22.33697845
13WNK32.17253877
14MAP3K122.13182395
15CASK2.06620029
16ZAK2.03464575
17PAK62.01760958
18KSR11.94111184
19MAP2K41.86447795
20ARAF1.84739749
21PLK21.80018700
22BMPR1B1.79465732
23DAPK11.75823761
24PRKD31.74650597
25NTRK11.73884668
26ADRBK21.72951375
27GRK51.69464605
28TRIM281.59688843
29NTRK21.58867284
30CAMKK11.51559867
31GRK11.50890821
32PHKG21.50459476
33PHKG11.50459476
34MKNK21.50207863
35NUAK11.49352784
36PNCK1.46717717
37CDK51.43543606
38DYRK21.40324965
39WNK41.37361639
40MAP3K131.36588158
41STK391.36293745
42LMTK21.35804236
43PRPF4B1.35567401
44CSNK1G11.34491967
45CSNK1G31.33549753
46SIK21.31655663
47PTK2B1.26021514
48TAOK31.23660753
49LATS21.20819151
50CDC71.20597091
51PRKCG1.20275441
52CDK191.19019402
53BCR1.18856622
54MAPK131.18691447
55CSNK1A1L1.16178948
56MKNK11.16093754
57NME11.15387116
58STK381.14761021
59MAP3K21.11857524
60RAF11.11342628
61CAMK2A1.08405732
62PLK31.06398809
63ACVR1B1.02024829
64TNIK1.01007230
65PINK11.00550425
66BMPR21.00011462
67CAMKK20.96958254
68TAF10.96159901
69BCKDK0.95682062
70CAMK2B0.91093272
71FES0.91087053
72TLK10.89931380
73INSRR0.89105219
74UHMK10.88927544
75CDK140.88069274
76CDK180.87391546
77NEK10.84107347
78CDK150.84094972
79TSSK60.80968404
80PAK30.80493173
81STK38L0.80110630
82TYRO30.79405659
83PLK40.78927698
84CAMK10.76219446
85SGK2230.75060098
86SGK4940.75060098
87VRK10.75021515
88CDK11A0.72855181
89PKN10.71883042
90RET0.70491643
91SGK20.68970552
92FGR0.67686796
93PLK10.67097678
94BRAF0.65049538
95STK110.63456771
96WEE10.63112516
97ATR0.62630897
98CAMK2D0.62523944
99DYRK1A0.62518100
100VRK20.62275923
101CCNB10.61869628
102SGK10.61514244
103PDK30.61280892
104PDK40.61280892
105PDK10.59358134
106MST40.58504122
107MAP2K10.58462500
108SRPK10.58190721
109ERBB30.57156585
110CAMK1G0.56889253
111TAOK10.56554071
112MAP3K10.56246962
113PDPK10.54745812
114EIF2AK10.53469735
115CSNK1A10.53460329
116MARK20.52828108
117ADRBK10.52301049
118PRKCH0.51982965
119PRKCE0.51342340
120CSNK1G20.50881963
121SGK30.50822387
122DMPK0.50146026
123CSNK1E0.48811452
124FGFR20.47621449
125CHEK20.47253319
126CAMK2G0.46942476
127PRKCZ0.46161283
128OXSR10.45720918
129FER0.44532884
130AKT30.43576222
131STK160.42686842
132DAPK30.42656235
133MUSK0.41820789
134SIK30.41767440
135CDC42BPA0.41744911
136AURKA0.41160498
137PRKACA0.41092253
138BRSK20.40802071
139PRKCI0.40250500
140MAP3K60.40212791
141CSNK1D0.39513476
142RPS6KA30.39361221
143ERBB20.37451334
144LIMK10.37188123
145TTK0.37183810
146SCYL20.36743236
147MAP3K70.36102701
148MAPK100.35899761
149MAPK120.35883990
150ALK0.34995546
151TNK20.33049198
152ROCK20.32889686
153CAMK40.31490773

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68359167
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20259967
3Long-term potentiation_Homo sapiens_hsa047202.97348413
4Olfactory transduction_Homo sapiens_hsa047402.79371435
5Circadian entrainment_Homo sapiens_hsa047132.75841573
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72430743
7Amphetamine addiction_Homo sapiens_hsa050312.54187138
8Glutamatergic synapse_Homo sapiens_hsa047242.53499612
9GABAergic synapse_Homo sapiens_hsa047272.50675712
10Morphine addiction_Homo sapiens_hsa050322.43610464
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.40147453
12Dopaminergic synapse_Homo sapiens_hsa047282.23250260
13Salivary secretion_Homo sapiens_hsa049702.21772730
14Insulin secretion_Homo sapiens_hsa049112.00848865
15Taste transduction_Homo sapiens_hsa047421.89013801
16Cholinergic synapse_Homo sapiens_hsa047251.88288408
17Gastric acid secretion_Homo sapiens_hsa049711.86701581
18Butanoate metabolism_Homo sapiens_hsa006501.82976658
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81099164
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80938240
21Renin secretion_Homo sapiens_hsa049241.79187838
22Homologous recombination_Homo sapiens_hsa034401.78143811
23Long-term depression_Homo sapiens_hsa047301.74893109
24Calcium signaling pathway_Homo sapiens_hsa040201.74605277
25Oxytocin signaling pathway_Homo sapiens_hsa049211.74041106
26Propanoate metabolism_Homo sapiens_hsa006401.66840655
27Serotonergic synapse_Homo sapiens_hsa047261.66222006
28Fanconi anemia pathway_Homo sapiens_hsa034601.62505294
29Collecting duct acid secretion_Homo sapiens_hsa049661.62403338
30Cardiac muscle contraction_Homo sapiens_hsa042601.58865444
31Selenocompound metabolism_Homo sapiens_hsa004501.56418367
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54853057
33Basal transcription factors_Homo sapiens_hsa030221.54610765
34RNA polymerase_Homo sapiens_hsa030201.51129212
35GnRH signaling pathway_Homo sapiens_hsa049121.50499622
36One carbon pool by folate_Homo sapiens_hsa006701.49061311
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46895046
38Steroid biosynthesis_Homo sapiens_hsa001001.46093200
39Gap junction_Homo sapiens_hsa045401.45751119
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45431801
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41981472
42Cocaine addiction_Homo sapiens_hsa050301.40084816
43Non-homologous end-joining_Homo sapiens_hsa034501.38670032
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33468593
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.30078004
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27932575
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26302705
48cAMP signaling pathway_Homo sapiens_hsa040241.25906783
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25165848
50RNA degradation_Homo sapiens_hsa030181.19609959
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16131716
52Glioma_Homo sapiens_hsa052141.15379937
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14355880
54Protein export_Homo sapiens_hsa030601.13946721
55Linoleic acid metabolism_Homo sapiens_hsa005911.13905823
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10328580
57Estrogen signaling pathway_Homo sapiens_hsa049151.08694884
58Vitamin B6 metabolism_Homo sapiens_hsa007501.08619025
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08062311
60Axon guidance_Homo sapiens_hsa043601.07857126
61Alzheimers disease_Homo sapiens_hsa050101.07378159
62Oocyte meiosis_Homo sapiens_hsa041141.06574866
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06427964
64Melanogenesis_Homo sapiens_hsa049161.05701964
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03849492
66Type II diabetes mellitus_Homo sapiens_hsa049301.03134886
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02262873
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01405268
69Oxidative phosphorylation_Homo sapiens_hsa001901.01355050
70Mismatch repair_Homo sapiens_hsa034301.00800803
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99305748
72Vibrio cholerae infection_Homo sapiens_hsa051100.99016116
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98467581
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.97185911
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95664510
76ErbB signaling pathway_Homo sapiens_hsa040120.95402422
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.93281923
78Regulation of autophagy_Homo sapiens_hsa041400.91637447
79Dilated cardiomyopathy_Homo sapiens_hsa054140.90555065
80Parkinsons disease_Homo sapiens_hsa050120.89964875
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87098234
82Purine metabolism_Homo sapiens_hsa002300.85617829
83Phototransduction_Homo sapiens_hsa047440.83515221
84Fatty acid elongation_Homo sapiens_hsa000620.81909698
85Pancreatic secretion_Homo sapiens_hsa049720.81905250
86Base excision repair_Homo sapiens_hsa034100.80860752
87beta-Alanine metabolism_Homo sapiens_hsa004100.79768726
88Ether lipid metabolism_Homo sapiens_hsa005650.78599683
89Dorso-ventral axis formation_Homo sapiens_hsa043200.78120768
90Tryptophan metabolism_Homo sapiens_hsa003800.76088496
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76073821
92VEGF signaling pathway_Homo sapiens_hsa043700.75892762
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74412933
94Glucagon signaling pathway_Homo sapiens_hsa049220.73528271
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.71589971
96Arginine and proline metabolism_Homo sapiens_hsa003300.71546437
97DNA replication_Homo sapiens_hsa030300.71413601
98RNA transport_Homo sapiens_hsa030130.71147417
99Thyroid hormone synthesis_Homo sapiens_hsa049180.70694751
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70051093
101Peroxisome_Homo sapiens_hsa041460.69547547
102Choline metabolism in cancer_Homo sapiens_hsa052310.67489699
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64597260
104Pyrimidine metabolism_Homo sapiens_hsa002400.63839747
105MAPK signaling pathway_Homo sapiens_hsa040100.63691484
106Huntingtons disease_Homo sapiens_hsa050160.62012939
107Pyruvate metabolism_Homo sapiens_hsa006200.61587480
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.59087571
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58408949
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58230121
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55291361
112Nucleotide excision repair_Homo sapiens_hsa034200.54347824
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53409519
114Metabolic pathways_Homo sapiens_hsa011000.53019427
115Ras signaling pathway_Homo sapiens_hsa040140.52937469
116Rap1 signaling pathway_Homo sapiens_hsa040150.52731112
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.52186625
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51269807
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50532777
120Spliceosome_Homo sapiens_hsa030400.50344820
121Proteasome_Homo sapiens_hsa030500.50197242
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49736371
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.48940573
124Insulin signaling pathway_Homo sapiens_hsa049100.47530598
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46753949
126Circadian rhythm_Homo sapiens_hsa047100.46678718
127Hippo signaling pathway_Homo sapiens_hsa043900.46354939
128mTOR signaling pathway_Homo sapiens_hsa041500.46263882
129Fatty acid metabolism_Homo sapiens_hsa012120.46101052
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.46030432
131Glycerolipid metabolism_Homo sapiens_hsa005610.45878363
132Hedgehog signaling pathway_Homo sapiens_hsa043400.44658758
133Alcoholism_Homo sapiens_hsa050340.43568441
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43038809
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42748303
136African trypanosomiasis_Homo sapiens_hsa051430.41963910
137Caffeine metabolism_Homo sapiens_hsa002320.41610857
138mRNA surveillance pathway_Homo sapiens_hsa030150.41426776
139Inositol phosphate metabolism_Homo sapiens_hsa005620.41352738
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39497211
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38950151
142Wnt signaling pathway_Homo sapiens_hsa043100.38653479
143Prion diseases_Homo sapiens_hsa050200.38652738
144Non-small cell lung cancer_Homo sapiens_hsa052230.37217521
145Endocytosis_Homo sapiens_hsa041440.35832969
146Renal cell carcinoma_Homo sapiens_hsa052110.33980892
147Endometrial cancer_Homo sapiens_hsa052130.32467971
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32444382
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30104377
150Bile secretion_Homo sapiens_hsa049760.29325699
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29242466
152Type I diabetes mellitus_Homo sapiens_hsa049400.28824634
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.27902878
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26095942
155Nitrogen metabolism_Homo sapiens_hsa009100.25766824
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23298997
1572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23272491
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23138986

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