ACTR3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.99667179
2DNA deamination (GO:0045006)6.20115339
3cytidine deamination (GO:0009972)6.11390553
4cytidine metabolic process (GO:0046087)6.11390553
5cytidine catabolic process (GO:0006216)6.11390553
6RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)5.16882350
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.14703492
8positive regulation of isotype switching (GO:0045830)4.94655619
9positive regulation of natural killer cell differentiation (GO:0032825)4.75928828
10regulation of B cell receptor signaling pathway (GO:0050855)4.74794229
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.66449759
12positive regulation of DNA recombination (GO:0045911)4.49216614
13regulation of activation of Janus kinase activity (GO:0010533)4.25743870
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.21399382
15positive regulation of histone H3-K4 methylation (GO:0051571)4.20596399
16water-soluble vitamin biosynthetic process (GO:0042364)4.19086867
17Arp2/3 complex-mediated actin nucleation (GO:0034314)4.14481263
18protein complex biogenesis (GO:0070271)4.07190431
19actin nucleation (GO:0045010)3.99373203
20maturation of 5.8S rRNA (GO:0000460)3.91774489
21negative regulation of mast cell activation (GO:0033004)3.89210143
22positive regulation of immunoglobulin mediated immune response (GO:0002891)3.86306705
23positive regulation of B cell mediated immunity (GO:0002714)3.86306705
24iron-sulfur cluster assembly (GO:0016226)3.85346465
25metallo-sulfur cluster assembly (GO:0031163)3.85346465
26negative regulation of phagocytosis (GO:0050765)3.82638457
27positive T cell selection (GO:0043368)3.75932972
28positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.75192186
29pyrimidine nucleotide catabolic process (GO:0006244)3.75124223
30mitochondrial respiratory chain complex assembly (GO:0033108)3.68385207
31replicative senescence (GO:0090399)3.67002031
32isoprenoid biosynthetic process (GO:0008299)3.65421036
33hepatocyte apoptotic process (GO:0097284)3.61991974
34ubiquinone biosynthetic process (GO:0006744)3.60076993
35proteasome assembly (GO:0043248)3.57198816
36ubiquinone metabolic process (GO:0006743)3.52828861
37quinone biosynthetic process (GO:1901663)3.50385545
38terpenoid biosynthetic process (GO:0016114)3.46716654
39positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.43699360
40response to interferon-beta (GO:0035456)3.38378631
41regulation of natural killer cell differentiation (GO:0032823)3.35562909
42cellular response to zinc ion (GO:0071294)3.34878989
43platelet dense granule organization (GO:0060155)3.29631668
44regulation of mitochondrial translation (GO:0070129)3.27945549
45positive regulation of natural killer cell mediated immunity (GO:0002717)3.27556918
46positive regulation of immunoglobulin production (GO:0002639)3.27216030
47negative regulation of viral genome replication (GO:0045071)3.24470378
48antigen processing and presentation via MHC class Ib (GO:0002475)3.23061723
49pyrimidine nucleoside catabolic process (GO:0046135)3.18505999
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11661842
51negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.11397385
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10987487
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10987487
54mannosylation (GO:0097502)3.07855086
55protein heterotetramerization (GO:0051290)3.07670322
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07328393
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07265087
58DNA demethylation (GO:0080111)3.05942494
59regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.05567493
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.04030053
61NADH dehydrogenase complex assembly (GO:0010257)3.04030053
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04030053
63cytochrome complex assembly (GO:0017004)3.03795659
64regulation of cellular amino acid metabolic process (GO:0006521)3.02430326
65pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.01549693
66regulation of T cell chemotaxis (GO:0010819)3.00551615
67positive regulation of T cell chemotaxis (GO:0010820)3.00551615
68positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.00508797
69cellular response to interleukin-15 (GO:0071350)3.00260225
70protein deneddylation (GO:0000338)2.90166444
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88262072
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87125158
73rRNA catabolic process (GO:0016075)2.84269076
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83995792
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83995792
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83995792
77transcription elongation from RNA polymerase I promoter (GO:0006362)2.83040031
78regulation of T cell receptor signaling pathway (GO:0050856)2.81302460
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78766531
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78725108
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78725108
82energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78111098
83ATP synthesis coupled proton transport (GO:0015986)2.78111098
84negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.76322677
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.75055898
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72709253
87negative regulation of ligase activity (GO:0051352)2.72709253
88positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.72080594
89negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.70960826
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70915607
91respiratory electron transport chain (GO:0022904)2.70519797
92regulation of isotype switching (GO:0045191)2.70484755
93positive regulation of cell killing (GO:0031343)2.68018894
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67521491
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.66835344
96signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66835344
97adenosine metabolic process (GO:0046085)2.66721513
98pseudouridine synthesis (GO:0001522)2.66527475
99T cell selection (GO:0045058)2.64174158
100electron transport chain (GO:0022900)2.63937371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.19462372
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.03943949
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.85163614
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.77610229
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.55425861
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.44001235
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.39877692
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.11477030
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10331834
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07910185
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.03302032
12VDR_23849224_ChIP-Seq_CD4+_Human2.51616493
13ELK1_19687146_ChIP-ChIP_HELA_Human2.48922876
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44818847
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34127525
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12987202
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10220764
18VDR_22108803_ChIP-Seq_LS180_Human2.06429255
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.04902620
20GATA3_26560356_Chip-Seq_TH2_Human2.02696288
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.00828004
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.00436409
23MYB_26560356_Chip-Seq_TH2_Human1.94136731
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86619377
25GATA1_22025678_ChIP-Seq_K562_Human1.85744739
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82303850
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81925037
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75494691
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.72384928
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72356087
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68087797
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67503604
33RUNX_20019798_ChIP-Seq_JUKART_Human1.64239231
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.60645985
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46753200
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46355666
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45129766
38AR_20517297_ChIP-Seq_VCAP_Human1.45033660
39GATA3_27048872_Chip-Seq_THYMUS_Human1.42344292
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.38159249
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35830941
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35418894
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.32874412
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.31316567
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30806472
46CBP_20019798_ChIP-Seq_JUKART_Human1.30806472
47FOXP3_21729870_ChIP-Seq_TREG_Human1.29693783
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26757190
49NCOR_22424771_ChIP-Seq_293T_Human1.26123259
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24304436
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20941218
52MYB_26560356_Chip-Seq_TH1_Human1.20891809
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16993530
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16937568
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15428007
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14110531
57EWS_26573619_Chip-Seq_HEK293_Human1.13643082
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13635939
59GABP_19822575_ChIP-Seq_HepG2_Human1.13551874
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11669721
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.10508919
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10231306
63STAT1_20625510_ChIP-Seq_HELA_Human1.08933846
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.08046726
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08046726
66NANOG_20526341_ChIP-Seq_ESCs_Human1.04556333
67P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04476657
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02754223
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02364900
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02049603
71MYC_18940864_ChIP-ChIP_HL60_Human1.01709819
72HOXB7_26014856_ChIP-Seq_BT474_Human1.01218516
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00528878
74BCAT_22108803_ChIP-Seq_LS180_Human0.99448276
75CTCF_20526341_ChIP-Seq_ESCs_Human0.99268160
76HTT_18923047_ChIP-ChIP_STHdh_Human0.98963476
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97970472
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97325628
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96683365
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92970849
81SPI1_23547873_ChIP-Seq_NB4_Human0.91846260
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91302201
83FUS_26573619_Chip-Seq_HEK293_Human0.90038206
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.89634590
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89105079
86BCL6_27268052_Chip-Seq_Bcells_Human0.89086896
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88795353
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88272682
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88042908
90ERA_21632823_ChIP-Seq_H3396_Human0.87951116
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87388525
92CIITA_25753668_ChIP-Seq_RAJI_Human0.87353507
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86352739
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86121343
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.85695024
96TP53_22573176_ChIP-Seq_HFKS_Human0.82640426
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82301018
98MAF_26560356_Chip-Seq_TH2_Human0.81982066
99EZH2_22144423_ChIP-Seq_EOC_Human0.81863844
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81577162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.75707386
2MP0005671_abnormal_response_to5.03861502
3MP0008057_abnormal_DNA_replication4.54645975
4MP0000685_abnormal_immune_system3.54011919
5MP0002166_altered_tumor_susceptibility3.14115830
6MP0005387_immune_system_phenotype3.13493549
7MP0001790_abnormal_immune_system3.13493549
8MP0001835_abnormal_antigen_presentation3.05313859
9MP0009785_altered_susceptibility_to3.02364693
10MP0003646_muscle_fatigue2.57566091
11MP0003763_abnormal_thymus_physiology2.56174409
12MP0002006_tumorigenesis2.50700860
13MP0002653_abnormal_ependyma_morphology2.34414507
14MP0001800_abnormal_humoral_immune2.06264255
15MP0004147_increased_porphyrin_level1.95389980
16MP0002876_abnormal_thyroid_physiology1.87629124
17MP0003195_calcinosis1.81415991
18MP0005408_hypopigmentation1.81313072
19MP0003172_abnormal_lysosome_physiology1.77201333
20MP0002148_abnormal_hypersensitivity_rea1.76253726
21MP0003880_abnormal_central_pattern1.72692470
22MP0005025_abnormal_response_to1.68029188
23MP0005075_abnormal_melanosome_morpholog1.65048827
24MP0004145_abnormal_muscle_electrophysio1.62874157
25MP0001968_abnormal_touch/_nociception1.60984947
26MP0002723_abnormal_immune_serum1.57309623
27MP0003436_decreased_susceptibility_to1.56168461
28MP0000372_irregular_coat_pigmentation1.55348308
29MP0005377_hearing/vestibular/ear_phenot1.53896942
30MP0003878_abnormal_ear_physiology1.53896942
31MP0009840_abnormal_foam_cell1.52979672
32MP0005645_abnormal_hypothalamus_physiol1.50975022
33MP0001873_stomach_inflammation1.50537966
34MP0002277_abnormal_respiratory_mucosa1.45890896
35MP0009764_decreased_sensitivity_to1.43061018
36MP0005000_abnormal_immune_tolerance1.42497397
37MP0001533_abnormal_skeleton_physiology1.37964876
38MP0002420_abnormal_adaptive_immunity1.37017544
39MP0002452_abnormal_antigen_presenting1.35748786
40MP0001819_abnormal_immune_cell1.35711583
41MP0004885_abnormal_endolymph1.33203649
42MP0000569_abnormal_digit_pigmentation1.32035071
43MP0002837_dystrophic_cardiac_calcinosis1.31857117
44MP0002095_abnormal_skin_pigmentation1.31562739
45MP0001905_abnormal_dopamine_level1.28597803
46MP0003638_abnormal_response/metabolism_1.28311463
47MP0001243_abnormal_dermal_layer1.17839408
48MP0001853_heart_inflammation1.13248732
49MP0008872_abnormal_physiological_respon1.13005803
50MP0005319_abnormal_enzyme/_coenzyme1.11693531
51MP0005503_abnormal_tendon_morphology1.09323710
52MP0005084_abnormal_gallbladder_morpholo1.08401549
53MP0010155_abnormal_intestine_physiology1.07405227
54MP0002102_abnormal_ear_morphology1.06947062
55MP0001845_abnormal_inflammatory_respons1.05913370
56MP0009278_abnormal_bone_marrow1.05450022
57MP0002933_joint_inflammation1.05241505
58MP0000716_abnormal_immune_system1.05219822
59MP0002735_abnormal_chemical_nociception1.02731143
60MP0002736_abnormal_nociception_after0.99745003
61MP0002398_abnormal_bone_marrow0.99039341
62MP0000490_abnormal_crypts_of0.95644344
63MP0000858_altered_metastatic_potential0.92601295
64MP0004381_abnormal_hair_follicle0.91285395
65MP0003866_abnormal_defecation0.88704160
66MP0009643_abnormal_urine_homeostasis0.87216401
67MP0003724_increased_susceptibility_to0.85156191
68MP0004019_abnormal_vitamin_homeostasis0.83619428
69MP0002419_abnormal_innate_immunity0.83375012
70MP0002405_respiratory_system_inflammati0.81392530
71MP0001485_abnormal_pinna_reflex0.81343563
72MP0008058_abnormal_DNA_repair0.81078003
73MP0000703_abnormal_thymus_morphology0.80835545
74MP0005464_abnormal_platelet_physiology0.79819119
75MP0002429_abnormal_blood_cell0.78094745
76MP0008469_abnormal_protein_level0.77727375
77MP0004947_skin_inflammation0.76829995
78MP0008775_abnormal_heart_ventricle0.76233115
79MP0000613_abnormal_salivary_gland0.75315962
80MP0008875_abnormal_xenobiotic_pharmacok0.74979307
81MP0004957_abnormal_blastocyst_morpholog0.74391787
82MP0001958_emphysema0.73645717
83MP0002722_abnormal_immune_system0.73420257
84MP0005390_skeleton_phenotype0.71129853
85MP0003448_altered_tumor_morphology0.70956500
86MP0002938_white_spotting0.68960722
87MP0003806_abnormal_nucleotide_metabolis0.68799636
88MP0006036_abnormal_mitochondrial_physio0.68259502
89MP0001663_abnormal_digestive_system0.67129888
90MP0001119_abnormal_female_reproductive0.66960508
91MP0000689_abnormal_spleen_morphology0.65579088
92MP0002693_abnormal_pancreas_physiology0.65180813
93MP0004215_abnormal_myocardial_fiber0.64562089
94MP0005584_abnormal_enzyme/coenzyme_acti0.63581515
95MP0000604_amyloidosis0.63251353
96MP0006035_abnormal_mitochondrial_morpho0.63210011
97MP0005266_abnormal_metabolism0.62674437
98MP0005410_abnormal_fertilization0.62487341
99MP0003137_abnormal_impulse_conducting0.61221916
100MP0002733_abnormal_thermal_nociception0.60748057

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)4.33772763
2Stomatitis (HP:0010280)4.06454302
3Increased IgM level (HP:0003496)4.03727378
4Hypoproteinemia (HP:0003075)3.86270652
5IgG deficiency (HP:0004315)3.85636352
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.82620066
7Hepatocellular necrosis (HP:0001404)3.71734359
8Depressed nasal tip (HP:0000437)3.67512004
9Increased CSF lactate (HP:0002490)3.63534793
10Hepatic necrosis (HP:0002605)3.46056632
11Mitochondrial inheritance (HP:0001427)3.45344002
12Severe combined immunodeficiency (HP:0004430)3.42511722
13Aplastic anemia (HP:0001915)3.23420129
14Elevated erythrocyte sedimentation rate (HP:0003565)3.17316648
15Tongue fasciculations (HP:0001308)3.06551797
16Cutaneous melanoma (HP:0012056)3.05283516
17T lymphocytopenia (HP:0005403)3.04607295
18Prostate neoplasm (HP:0100787)2.98152312
19Increased hepatocellular lipid droplets (HP:0006565)2.97435372
20Acute necrotizing encephalopathy (HP:0006965)2.93993439
21Increased serum lactate (HP:0002151)2.92681807
22Abnormality of T cell number (HP:0011839)2.90743757
23Pustule (HP:0200039)2.89407832
24Aortic regurgitation (HP:0001659)2.87988723
25Renal Fanconi syndrome (HP:0001994)2.86501588
26Cellular immunodeficiency (HP:0005374)2.81007855
27Lipid accumulation in hepatocytes (HP:0006561)2.77196609
28Recurrent cutaneous fungal infections (HP:0011370)2.72491629
29Chronic mucocutaneous candidiasis (HP:0002728)2.72491629
30Abnormality of midbrain morphology (HP:0002418)2.72099509
31Molar tooth sign on MRI (HP:0002419)2.72099509
32Hyperactive renin-angiotensin system (HP:0000841)2.70993347
33Nephronophthisis (HP:0000090)2.63219533
34Muscle fibrillation (HP:0010546)2.60166788
35Combined immunodeficiency (HP:0005387)2.59998264
36Type II lissencephaly (HP:0007260)2.58273652
37Pancytopenia (HP:0001876)2.55811099
38Abnormality of renin-angiotensin system (HP:0000847)2.55728727
39Conical tooth (HP:0000698)2.50167035
40Thyroiditis (HP:0100646)2.50118454
41Constricted visual fields (HP:0001133)2.47049333
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46580943
43Abnormality of alanine metabolism (HP:0010916)2.46580943
44Hyperalaninemia (HP:0003348)2.46580943
45Mesangial abnormality (HP:0001966)2.46568669
46Progressive macrocephaly (HP:0004481)2.45853036
47Abnormal mitochondria in muscle tissue (HP:0008316)2.45574113
48Abnormality of the prostate (HP:0008775)2.45327210
49Abolished electroretinogram (ERG) (HP:0000550)2.37119994
50Metaphyseal dysplasia (HP:0100255)2.33468988
51Amelogenesis imperfecta (HP:0000705)2.33395913
52Acute encephalopathy (HP:0006846)2.32282382
53Lip pit (HP:0100267)2.29021445
54Pancreatic cysts (HP:0001737)2.27635459
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26199356
56Abnormal protein N-linked glycosylation (HP:0012347)2.26199356
57Abnormal protein glycosylation (HP:0012346)2.26199356
58Abnormal glycosylation (HP:0012345)2.26199356
59Abnormality of renal resorption (HP:0011038)2.23107717
60Abnormality of the vocal cords (HP:0008777)2.20954572
61Abnormality of T cells (HP:0002843)2.20084379
62Hypergammaglobulinemia (HP:0010702)2.20042673
63Abnormality of eosinophils (HP:0001879)2.19470597
64J-shaped sella turcica (HP:0002680)2.19046423
65Tubular atrophy (HP:0000092)2.18235615
66Methylmalonic aciduria (HP:0012120)2.17067563
67Exertional dyspnea (HP:0002875)2.13959103
68Hyperaldosteronism (HP:0000859)2.12983994
69Hypoalbuminemia (HP:0003073)2.12439142
70Abnormal albumin level (HP:0012116)2.12439142
71Nausea (HP:0002018)2.11724938
72Chronic diarrhea (HP:0002028)2.10882152
73Neonatal respiratory distress (HP:0002643)2.10596920
74Hypokalemic alkalosis (HP:0001949)2.05653696
75Diaphragmatic weakness (HP:0009113)2.00467305
76Ileus (HP:0002595)1.99922476
77Methylmalonic acidemia (HP:0002912)1.99301049
78Respiratory failure (HP:0002878)1.96923628
79Increased intramyocellular lipid droplets (HP:0012240)1.96092373
80Abnormality of the neuromuscular junction (HP:0003398)1.95926861
81Fatigable weakness (HP:0003473)1.95926861
82Recurrent fungal infections (HP:0002841)1.95715579
83Optic disc pallor (HP:0000543)1.93736703
84Parakeratosis (HP:0001036)1.93362731
85Eosinophilia (HP:0001880)1.93293371
86Chronic bronchitis (HP:0004469)1.92238942
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90775730
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.88093028
89Hypoplasia of the fovea (HP:0007750)1.88093028
90Retinal dysplasia (HP:0007973)1.86398465
91Paralysis (HP:0003470)1.85661546
92Bronchitis (HP:0012387)1.85390614
93Multiple enchondromatosis (HP:0005701)1.81193566
94Abnormality of dental color (HP:0011073)1.80863131
95Recurrent bronchitis (HP:0002837)1.80682389
96Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80164720
97Abnormality of the renal medulla (HP:0100957)1.79758654
983-Methylglutaconic aciduria (HP:0003535)1.79181875
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78340018
100Dicarboxylic aciduria (HP:0003215)1.78340018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.59508711
2VRK24.81633749
3CDK83.88758357
4BMPR1B3.76826022
5ZAK3.48238008
6TLK13.29291570
7TXK3.20825182
8TESK12.95298869
9KDR2.77355225
10MAP4K22.67310079
11VRK12.56146228
12TGFBR12.41730624
13TAF12.24449037
14TSSK62.20424013
15MST41.84881004
16NUAK11.66678679
17EIF2AK11.63573650
18ADRBK21.59349772
19FRK1.51550160
20GRK11.48431790
21STK381.40976955
22CDK91.31697689
23MAP3K141.24536242
24IKBKE1.21696315
25IKBKB1.18113565
26MKNK21.17838526
27EIF2AK21.17828697
28WNK41.16141099
29STK391.15666842
30BUB11.15223251
31RPS6KA41.11303618
32KIT1.10566726
33TESK21.10025220
34MAP3K121.03986484
35MYLK1.02769163
36PIK3CG1.01985684
37DAPK11.00550833
38BLK0.99931600
39AKT30.99690601
40TEC0.97731260
41PLK30.96497236
42SYK0.95063625
43SCYL20.92800244
44TAOK30.87513401
45ZAP700.84305892
46BTK0.82885086
47EIF2AK30.79259300
48TYK20.77565282
49MAPKAPK50.77162070
50TRIM280.74121170
51CSK0.73076597
52BMPR20.70993689
53OXSR10.70596253
54JAK30.69865352
55RPS6KA50.69103119
56PDK20.67826807
57LCK0.66446830
58DAPK30.62898603
59MAP4K10.60815501
60GRK50.57545520
61MAPKAPK30.57432173
62SMG10.56697217
63MAPKAPK20.53617198
64TGFBR20.52318065
65HCK0.49663494
66PRKD30.44078989
67ITK0.43884635
68LYN0.43380068
69PAK30.43058086
70CAMK2G0.41848458
71MKNK10.41802171
72CHUK0.38439551
73SIK30.38013725
74LIMK10.37161947
75TBK10.35803061
76JAK10.32775863
77WNK30.32020615
78STK38L0.31980057
79DYRK20.30679562
80ILK0.30625833
81PRKCQ0.30121806
82CAMK2D0.30023134
83INSRR0.29467138
84FGFR30.29441674
85PRKCE0.28846204
86TAOK20.27722415
87PRKCG0.27298442
88BCKDK0.26277229
89PKN10.25623678
90TIE10.24724056
91CSNK1A10.24479393
92IGF1R0.24412577
93PIM10.24273203
94SRPK10.24110057
95GRK70.23846751
96ADRBK10.21171486
97ROCK10.20635094
98CHEK20.20157157
99MAPK130.19760396
100CDK70.17258357

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.13255176
2Sulfur metabolism_Homo sapiens_hsa009204.46635728
3Primary immunodeficiency_Homo sapiens_hsa053403.60937808
4Oxidative phosphorylation_Homo sapiens_hsa001903.24446827
5Parkinsons disease_Homo sapiens_hsa050122.71106782
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.38139005
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33695742
8Nitrogen metabolism_Homo sapiens_hsa009102.17708041
9Hematopoietic cell lineage_Homo sapiens_hsa046402.16270365
10Antigen processing and presentation_Homo sapiens_hsa046122.14061738
11RNA polymerase_Homo sapiens_hsa030201.92093985
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90289789
13One carbon pool by folate_Homo sapiens_hsa006701.85245232
14Huntingtons disease_Homo sapiens_hsa050161.84346349
15RNA degradation_Homo sapiens_hsa030181.82206824
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.79175241
17Basal transcription factors_Homo sapiens_hsa030221.72953055
18Protein export_Homo sapiens_hsa030601.72887895
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.67686918
20Allograft rejection_Homo sapiens_hsa053301.65535417
21Graft-versus-host disease_Homo sapiens_hsa053321.64266541
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50541406
23T cell receptor signaling pathway_Homo sapiens_hsa046601.50038901
24Autoimmune thyroid disease_Homo sapiens_hsa053201.49505438
25Alzheimers disease_Homo sapiens_hsa050101.41509290
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41096587
27Ribosome_Homo sapiens_hsa030101.40589804
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37006861
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34804223
30Type I diabetes mellitus_Homo sapiens_hsa049401.32466649
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31504106
32Tryptophan metabolism_Homo sapiens_hsa003801.28821283
33Cardiac muscle contraction_Homo sapiens_hsa042601.19102027
34Shigellosis_Homo sapiens_hsa051311.15131796
35Malaria_Homo sapiens_hsa051441.14594190
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13282849
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08241816
38Dorso-ventral axis formation_Homo sapiens_hsa043201.08056356
39Regulation of autophagy_Homo sapiens_hsa041401.06881360
40Folate biosynthesis_Homo sapiens_hsa007901.04144051
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03308354
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02350285
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.99421384
44Asthma_Homo sapiens_hsa053100.97382932
45Homologous recombination_Homo sapiens_hsa034400.93942542
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93871974
47Rheumatoid arthritis_Homo sapiens_hsa053230.93208027
48Phototransduction_Homo sapiens_hsa047440.90823028
49Herpes simplex infection_Homo sapiens_hsa051680.90443977
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.88130953
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80324502
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79456797
53Measles_Homo sapiens_hsa051620.79046615
54Purine metabolism_Homo sapiens_hsa002300.77548331
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76366917
56Fatty acid degradation_Homo sapiens_hsa000710.72179464
57Peroxisome_Homo sapiens_hsa041460.69206912
58Vitamin digestion and absorption_Homo sapiens_hsa049770.68881265
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68873889
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67813892
61N-Glycan biosynthesis_Homo sapiens_hsa005100.65628423
62Sulfur relay system_Homo sapiens_hsa041220.64244887
63Propanoate metabolism_Homo sapiens_hsa006400.64035118
64Arachidonic acid metabolism_Homo sapiens_hsa005900.63814004
65Butanoate metabolism_Homo sapiens_hsa006500.62794626
66Epstein-Barr virus infection_Homo sapiens_hsa051690.62775086
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57102890
68Chemical carcinogenesis_Homo sapiens_hsa052040.56179720
69Steroid biosynthesis_Homo sapiens_hsa001000.56132997
70RNA transport_Homo sapiens_hsa030130.55962436
71Linoleic acid metabolism_Homo sapiens_hsa005910.55243582
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53649785
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52018802
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50280900
75Pyrimidine metabolism_Homo sapiens_hsa002400.50081921
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49671771
77Metabolic pathways_Homo sapiens_hsa011000.49010648
78Retinol metabolism_Homo sapiens_hsa008300.45540699
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.44637543
80HTLV-I infection_Homo sapiens_hsa051660.44572386
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43817253
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43587946
83Systemic lupus erythematosus_Homo sapiens_hsa053220.43091988
84Spliceosome_Homo sapiens_hsa030400.39987050
85Glycerolipid metabolism_Homo sapiens_hsa005610.39031266
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37639645
87Ether lipid metabolism_Homo sapiens_hsa005650.34590351
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.34072694
89Collecting duct acid secretion_Homo sapiens_hsa049660.33199931
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32241397
91Olfactory transduction_Homo sapiens_hsa047400.30128468
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.30126680
93Fat digestion and absorption_Homo sapiens_hsa049750.26838547
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26528296
95Legionellosis_Homo sapiens_hsa051340.25710804
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23507498
97Oocyte meiosis_Homo sapiens_hsa041140.23189157
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.23181318
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.22112997
100Fatty acid metabolism_Homo sapiens_hsa012120.21485093

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