ACTR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.86030553
2replication fork processing (GO:0031297)7.18353008
3transcription from mitochondrial promoter (GO:0006390)6.92037519
4embryonic process involved in female pregnancy (GO:0060136)6.83234629
5proline metabolic process (GO:0006560)6.66205510
6DNA deamination (GO:0045006)6.47887247
7positive regulation of protein homooligomerization (GO:0032464)6.41510984
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.32382391
9regulation of integrin activation (GO:0033623)5.48836845
10oxidative demethylation (GO:0070989)5.21313820
11DNA strand renaturation (GO:0000733)5.20546997
12regulation of protein homooligomerization (GO:0032462)5.09596289
13mitochondrial DNA metabolic process (GO:0032042)5.04590584
14somatic diversification of immune receptors via somatic mutation (GO:0002566)5.03324685
15somatic hypermutation of immunoglobulin genes (GO:0016446)5.03324685
16poly(A)+ mRNA export from nucleus (GO:0016973)5.03253301
17establishment of apical/basal cell polarity (GO:0035089)4.88623957
18mitotic G1 DNA damage checkpoint (GO:0031571)4.57948450
19viral mRNA export from host cell nucleus (GO:0046784)4.55218857
20telomere maintenance via semi-conservative replication (GO:0032201)4.33152162
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.29185843
22base-excision repair (GO:0006284)4.24193620
23DNA topological change (GO:0006265)4.22625384
24mRNA cleavage (GO:0006379)4.12473241
25establishment of monopolar cell polarity (GO:0061162)4.10217707
26establishment or maintenance of monopolar cell polarity (GO:0061339)4.10217707
27mitotic G1/S transition checkpoint (GO:0044819)4.08997555
28G1 DNA damage checkpoint (GO:0044783)4.08617712
29cellular response to zinc ion (GO:0071294)4.06581485
30regulation of translational fidelity (GO:0006450)4.01418343
31embryonic placenta development (GO:0001892)4.01140346
32formation of translation preinitiation complex (GO:0001731)3.94723974
33meiotic chromosome segregation (GO:0045132)3.93454326
34negative regulation of mRNA processing (GO:0050686)3.89783185
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.89213716
36negative regulation of JAK-STAT cascade (GO:0046426)3.88838896
37negative regulation of cell cycle arrest (GO:0071157)3.86859977
38dosage compensation (GO:0007549)3.84672861
39nuclear pore complex assembly (GO:0051292)3.82566738
40establishment of integrated proviral latency (GO:0075713)3.81442741
41positive regulation of protein oligomerization (GO:0032461)3.77208671
42positive regulation by host of viral transcription (GO:0043923)3.76795465
43ribosome assembly (GO:0042255)3.76591682
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68600486
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68600486
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.68600486
47DNA integration (GO:0015074)3.67147223
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64694367
49spliceosomal tri-snRNP complex assembly (GO:0000244)3.61623662
50DNA double-strand break processing (GO:0000729)3.60368009
51telomere maintenance via recombination (GO:0000722)3.56577874
52termination of RNA polymerase II transcription (GO:0006369)3.56072989
53nuclear pore organization (GO:0006999)3.53820384
54establishment of viral latency (GO:0019043)3.53749234
55DNA strand elongation involved in DNA replication (GO:0006271)3.53249848
56peptidyl-arginine omega-N-methylation (GO:0035247)3.53106652
57regulation of RNA export from nucleus (GO:0046831)3.52462575
58mitochondrial RNA metabolic process (GO:0000959)3.52143879
59negative regulation of RNA splicing (GO:0033119)3.51789961
60proteasome assembly (GO:0043248)3.51561204
61kinetochore assembly (GO:0051382)3.48294169
62histone H4-K12 acetylation (GO:0043983)3.47508159
63trophectodermal cell differentiation (GO:0001829)3.44876263
64face development (GO:0060324)3.44033168
65double-strand break repair via nonhomologous end joining (GO:0006303)3.41582405
66non-recombinational repair (GO:0000726)3.41582405
67regulation of double-strand break repair via homologous recombination (GO:0010569)3.41359901
68glutamine family amino acid biosynthetic process (GO:0009084)3.40098788
69cellular response to ATP (GO:0071318)3.39650612
70regulation of sister chromatid cohesion (GO:0007063)3.39470028
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38894252
72negative regulation of fatty acid biosynthetic process (GO:0045717)3.37517554
73DNA strand elongation (GO:0022616)3.33498744
74positive regulation of developmental pigmentation (GO:0048087)3.32778034
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32381547
76negative regulation of ligase activity (GO:0051352)3.32178601
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32178601
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30346278
79regulation of protein oligomerization (GO:0032459)3.28611609
80regulation of DNA damage checkpoint (GO:2000001)3.24874981
81negative regulation of Ras GTPase activity (GO:0034261)3.22684793
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.20498509
83negative regulation of protein oligomerization (GO:0032460)3.19357719
84DNA ligation (GO:0006266)3.19239371
85base-excision repair, AP site formation (GO:0006285)3.18497244
86resolution of meiotic recombination intermediates (GO:0000712)3.15741762
87negative regulation of mRNA metabolic process (GO:1903312)3.15374430
88spliceosomal snRNP assembly (GO:0000387)3.15222980
89apoptotic process involved in morphogenesis (GO:0060561)3.12952524
90embryonic camera-type eye development (GO:0031076)3.12790223
91regulation of mitochondrial translation (GO:0070129)3.12274724
92tRNA methylation (GO:0030488)3.11683697
93Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10841985
94kinetochore organization (GO:0051383)3.10827668
95positive regulation of chromosome segregation (GO:0051984)3.10325989
96mitotic recombination (GO:0006312)3.10317086
97maturation of 5.8S rRNA (GO:0000460)3.09801966
98mitotic nuclear envelope disassembly (GO:0007077)3.07604078
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06645341
100histone arginine methylation (GO:0034969)3.05467163
101telomere maintenance via telomere lengthening (GO:0010833)3.04140044
102NIK/NF-kappaB signaling (GO:0038061)3.02668544
103peptidyl-arginine N-methylation (GO:0035246)3.02349278
104peptidyl-arginine methylation (GO:0018216)3.02349278
105regulation of double-strand break repair (GO:2000779)3.02164927
106pore complex assembly (GO:0046931)3.01336312
107negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.01112740
108mitotic metaphase plate congression (GO:0007080)3.00050901
109ribosome biogenesis (GO:0042254)2.99574738
110nuclear envelope disassembly (GO:0051081)2.97613096
111membrane disassembly (GO:0030397)2.97613096
112mitotic chromosome condensation (GO:0007076)2.97155366
113DNA demethylation (GO:0080111)2.97126580
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94158606
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93980738
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93980738
117mitotic sister chromatid segregation (GO:0000070)2.93519236
118negative regulation of interleukin-12 production (GO:0032695)2.92515114
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91217369
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89323661
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89323661
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89323661
123determination of adult lifespan (GO:0008340)2.88657600
124de novo protein folding (GO:0006458)2.87177404
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86100051
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.86100051
127mitochondrial DNA replication (GO:0006264)2.85354173
128negative regulation of tumor necrosis factor production (GO:0032720)2.84356032
129mRNA export from nucleus (GO:0006406)2.83065630
130de novo posttranslational protein folding (GO:0051084)2.82502486
131maturation of SSU-rRNA (GO:0030490)2.82333622
132signal transduction involved in cell cycle checkpoint (GO:0072395)2.82197403
133negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81034646
134regulation of cellular amino acid metabolic process (GO:0006521)2.78928149
135regulation of posttranscriptional gene silencing (GO:0060147)2.77903399
136regulation of gene silencing by miRNA (GO:0060964)2.77903399
137regulation of gene silencing by RNA (GO:0060966)2.77903399
138positive regulation of granulocyte differentiation (GO:0030854)2.77642831
139IMP biosynthetic process (GO:0006188)2.77569290
140nodal signaling pathway (GO:0038092)2.75747981
141negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.75374044
142DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.74446961
143V(D)J recombination (GO:0033151)2.74099358
144positive regulation of ligase activity (GO:0051351)2.74083484
145somatic cell DNA recombination (GO:0016444)2.73708952
146somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.73708952
147DNA damage response, detection of DNA damage (GO:0042769)2.73667914
148negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.72692125
149protein targeting to mitochondrion (GO:0006626)2.72569649
150ribonucleoprotein complex biogenesis (GO:0022613)2.70347694
151regulation of ubiquitin-protein transferase activity (GO:0051438)2.68850801
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68257203
153deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67955606
154rRNA modification (GO:0000154)2.65206114
155ribosomal large subunit biogenesis (GO:0042273)2.64893628
156pyrimidine nucleotide catabolic process (GO:0006244)2.63925447
157negative regulation of chromosome segregation (GO:0051985)2.61400511
158negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59370640
159negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59370640
160negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59370640
161negative regulation of mitotic sister chromatid separation (GO:2000816)2.59370640
162negative regulation of sister chromatid segregation (GO:0033046)2.59370640
163pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.58041100
164establishment of protein localization to mitochondrion (GO:0072655)2.57120060
165rRNA transcription (GO:0009303)2.56428890
166transcription-coupled nucleotide-excision repair (GO:0006283)2.56336815
167protein localization to mitochondrion (GO:0070585)2.56324911
168mitotic spindle assembly checkpoint (GO:0007094)2.56277460
169regulation of ligase activity (GO:0051340)2.55324159
170antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.54176334
171mRNA splicing, via spliceosome (GO:0000398)2.52014496
172RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.52014496
173regulation of translation in response to stress (GO:0043555)2.51699175
174rRNA processing (GO:0006364)2.50168950
175DNA unwinding involved in DNA replication (GO:0006268)2.49868607
176RNA splicing, via transesterification reactions (GO:0000375)2.49415049
177rRNA methylation (GO:0031167)2.49214247
1783-UTR-mediated mRNA stabilization (GO:0070935)2.49145683
179protein localization to chromosome, centromeric region (GO:0071459)2.48980654
180nuclear envelope organization (GO:0006998)2.48810615
181spindle assembly checkpoint (GO:0071173)2.47976022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.62058401
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.68042569
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23695566
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.06443734
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00900324
6VDR_21846776_ChIP-Seq_THP-1_Human2.92620426
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.89976054
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78579348
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77360647
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.73950079
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.70518565
12MYC_22102868_ChIP-Seq_BL_Human2.51446351
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.46132597
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42417513
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29909150
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.27581073
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25841230
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23781115
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23781115
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23781115
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23750992
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12762308
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.10651536
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06819635
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03487444
26FOXP3_21729870_ChIP-Seq_TREG_Human2.01168235
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89618504
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86691741
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85063150
30KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.83950526
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81938028
32* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79580629
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77759267
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77115061
35* CIITA_25753668_ChIP-Seq_RAJI_Human1.77056281
36PU.1_20513432_ChIP-Seq_Bcells_Mouse1.73363778
37SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71220351
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67988630
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67673468
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67225134
41LXR_22292898_ChIP-Seq_THP-1_Human1.66487594
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65132152
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64251567
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62369549
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60777873
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60716582
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.60085610
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54594118
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53817073
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53363842
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52948110
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52312065
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51863409
54* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49932011
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48689276
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46319840
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45624788
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.44815347
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44610594
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43665594
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43320393
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43167594
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.40883785
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40090784
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38780312
66KDM2B_26808549_Chip-Seq_DND41_Human1.38770095
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37874135
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35132639
69MAF_26560356_Chip-Seq_TH1_Human1.34626099
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33799308
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33773936
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32747543
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32271598
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.31253590
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30891322
76KDM5A_27292631_Chip-Seq_BREAST_Human1.30845458
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30519181
78TCF7_22412390_ChIP-Seq_EML_Mouse1.30162861
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.30046218
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29485730
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.28573451
82DCP1A_22483619_ChIP-Seq_HELA_Human1.28485412
83GABP_19822575_ChIP-Seq_HepG2_Human1.28347744
84VDR_24763502_ChIP-Seq_THP-1_Human1.28094423
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.27840031
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27409234
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26947587
88* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26941925
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26908163
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25887174
91* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25758138
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.25716889
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25609751
94XRN2_22483619_ChIP-Seq_HELA_Human1.25042262
95ELK1_19687146_ChIP-ChIP_HELA_Human1.24515177
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23672144
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23112778
98RACK7_27058665_Chip-Seq_MCF-7_Human1.22843872
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22428682
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.22241959
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19234011
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19124137
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18893111
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18543472
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18330129
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18223990
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18129915
108UTX_26944678_Chip-Seq_JUKART_Human1.17084019
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17014107
110POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15120675
111RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14319327
112MAF_26560356_Chip-Seq_TH2_Human1.14154306
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14127827
114EGR1_19374776_ChIP-ChIP_THP-1_Human1.13474240
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12982023
116SPI1_23547873_ChIP-Seq_NB4_Human1.12917955
117ETS1_21867929_ChIP-Seq_TH2_Mouse1.12716071
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11443017
119ZNF263_19887448_ChIP-Seq_K562_Human1.11157904
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10085923
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09869156
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09130455
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08259126
124TTF2_22483619_ChIP-Seq_HELA_Human1.08235670
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08149341
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07418279
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06862124
128ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06858129
129TFEB_21752829_ChIP-Seq_HELA_Human1.06125595
130RARB_24833708_ChIP-Seq_LIVER_Mouse1.05952317
131RUNX1_22412390_ChIP-Seq_EML_Mouse1.04272737
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02710118
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02427540
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02097965
135STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02038856
136MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01317760
137MYB_26560356_Chip-Seq_TH1_Human1.01268316
138* VDR_23849224_ChIP-Seq_CD4+_Human1.00875506
139TP63_19390658_ChIP-ChIP_HaCaT_Human1.00485920
140* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99202424
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97975883
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97098632
143PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94932913
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88601548
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86395777
146IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86289605
147NCOR1_26117541_ChIP-Seq_K562_Human0.86035233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.87574576
2MP0009278_abnormal_bone_marrow4.37609135
3MP0008260_abnormal_autophagy3.23091965
4MP0002009_preneoplasia3.14670233
5MP0005171_absent_coat_pigmentation3.09125934
6MP0010094_abnormal_chromosome_stability3.05277790
7MP0005397_hematopoietic_system_phenotyp2.56056917
8MP0001545_abnormal_hematopoietic_system2.56056917
9MP0003111_abnormal_nucleus_morphology2.50709305
10MP0005174_abnormal_tail_pigmentation2.40964168
11MP0010030_abnormal_orbit_morphology2.35739026
12MP0008995_early_reproductive_senescence2.34041486
13MP0008058_abnormal_DNA_repair2.26829401
14MP0004957_abnormal_blastocyst_morpholog2.24626171
15MP0003693_abnormal_embryo_hatching2.14623004
16MP0005076_abnormal_cell_differentiation2.12883207
17MP0006035_abnormal_mitochondrial_morpho2.12359167
18MP0001853_heart_inflammation2.12227075
19MP0005451_abnormal_body_composition2.09847574
20MP0003436_decreased_susceptibility_to2.05732198
21MP0000685_abnormal_immune_system2.00333816
22MP0003786_premature_aging1.98824297
23MP0004233_abnormal_muscle_weight1.96846479
24MP0003077_abnormal_cell_cycle1.93985479
25MP0003890_abnormal_embryonic-extraembry1.87529712
26MP0001348_abnormal_lacrimal_gland1.84064706
27MP0000490_abnormal_crypts_of1.83381488
28MP0003453_abnormal_keratinocyte_physiol1.77562076
29MP0003806_abnormal_nucleotide_metabolis1.71203428
30MP0005075_abnormal_melanosome_morpholog1.66975788
31MP0008877_abnormal_DNA_methylation1.62232853
32MP0002396_abnormal_hematopoietic_system1.61546868
33MP0010352_gastrointestinal_tract_polyps1.58805123
34MP0002086_abnormal_extraembryonic_tissu1.58542604
35MP0000015_abnormal_ear_pigmentation1.58483003
36MP0000371_diluted_coat_color1.56523813
37MP0003221_abnormal_cardiomyocyte_apopto1.49513834
38MP0002405_respiratory_system_inflammati1.48263646
39MP0003191_abnormal_cellular_cholesterol1.46455231
40MP0008789_abnormal_olfactory_epithelium1.45167003
41MP0003763_abnormal_thymus_physiology1.42237460
42MP0001697_abnormal_embryo_size1.42198867
43MP0005671_abnormal_response_to1.41599794
44MP0002653_abnormal_ependyma_morphology1.41043059
45MP0001293_anophthalmia1.40556530
46MP0009697_abnormal_copulation1.39797033
47MP0003567_abnormal_fetal_cardiomyocyte1.37827477
48MP0005499_abnormal_olfactory_system1.37741529
49MP0005394_taste/olfaction_phenotype1.37741529
50MP0002019_abnormal_tumor_incidence1.36992141
51MP0002084_abnormal_developmental_patter1.36849574
52MP0009333_abnormal_splenocyte_physiolog1.36767469
53MP0005000_abnormal_immune_tolerance1.36257142
54MP0010307_abnormal_tumor_latency1.34522581
55MP0004133_heterotaxia1.34172732
56MP0003119_abnormal_digestive_system1.33562057
57MP0000689_abnormal_spleen_morphology1.32762128
58MP0006082_CNS_inflammation1.32455876
59MP0002166_altered_tumor_susceptibility1.31296699
60MP0004197_abnormal_fetal_growth/weight/1.31075819
61MP0000358_abnormal_cell_content/1.29433759
62MP0001672_abnormal_embryogenesis/_devel1.28299766
63MP0005380_embryogenesis_phenotype1.28299766
64MP0001727_abnormal_embryo_implantation1.28069619
65MP0004947_skin_inflammation1.27998847
66MP0002085_abnormal_embryonic_tissue1.27828632
67MP0008932_abnormal_embryonic_tissue1.27631905
68MP0006036_abnormal_mitochondrial_physio1.27449196
69MP0000350_abnormal_cell_proliferation1.25918451
70MP0002398_abnormal_bone_marrow1.24550601
71MP0006072_abnormal_retinal_apoptosis1.22246402
72MP0000470_abnormal_stomach_morphology1.15040946
73MP0003172_abnormal_lysosome_physiology1.13963707
74MP0003828_pulmonary_edema1.13211182
75MP0001730_embryonic_growth_arrest1.11615407
76MP0002722_abnormal_immune_system1.10338872
77MP0000703_abnormal_thymus_morphology1.10038841
78MP0004185_abnormal_adipocyte_glucose1.09232165
79MP0009840_abnormal_foam_cell1.08318093
80MP0002249_abnormal_larynx_morphology1.08291027
81MP0005058_abnormal_lysosome_morphology1.07044017
82MP0003283_abnormal_digestive_organ1.06600120
83MP0002006_tumorigenesis1.06113649
84MP0000313_abnormal_cell_death1.05037989
85MP0002254_reproductive_system_inflammat1.03564343
86MP0000858_altered_metastatic_potential1.02019541
87MP0002148_abnormal_hypersensitivity_rea1.01737536
88MP0003984_embryonic_growth_retardation1.00799873
89MP0002419_abnormal_innate_immunity1.00771052
90MP0005384_cellular_phenotype1.00363541
91MP0002080_prenatal_lethality1.00146325
92MP0005025_abnormal_response_to0.98918478
93MP0002088_abnormal_embryonic_growth/wei0.97971434
94MP0002075_abnormal_coat/hair_pigmentati0.97888883
95MP0002132_abnormal_respiratory_system0.97726232
96MP0001529_abnormal_vocalization0.96783943
97MP0001800_abnormal_humoral_immune0.96250762
98MP0000579_abnormal_nail_morphology0.95977352
99MP0003186_abnormal_redox_activity0.95660006
100MP0010155_abnormal_intestine_physiology0.93807210
101MP0005621_abnormal_cell_physiology0.93426563
102MP0001873_stomach_inflammation0.92810766
103MP0000716_abnormal_immune_system0.89552757
104MP0002796_impaired_skin_barrier0.87958158
105MP0002429_abnormal_blood_cell0.87520491
106MP0002111_abnormal_tail_morphology0.86312865
107MP0005408_hypopigmentation0.86083885
108MP0002282_abnormal_trachea_morphology0.83709142
109MP0009115_abnormal_fat_cell0.83440769
110MP0001835_abnormal_antigen_presentation0.83299407
111MP0001186_pigmentation_phenotype0.82406999
112MP0002210_abnormal_sex_determination0.82317063
113MP0002060_abnormal_skin_morphology0.81820233
114MP0003045_fibrosis0.81736767
115MP0005464_abnormal_platelet_physiology0.81510800
116MP0001915_intracranial_hemorrhage0.81468436
117MP0002877_abnormal_melanocyte_morpholog0.80638257
118MP0005310_abnormal_salivary_gland0.80086121
119MP0004808_abnormal_hematopoietic_stem0.79737193
120MP0002452_abnormal_antigen_presenting0.76650659
121MP0008007_abnormal_cellular_replicative0.75760220
122MP0002269_muscular_atrophy0.74504815
123MP0003718_maternal_effect0.74259397
124MP0002138_abnormal_hepatobiliary_system0.73792684
125MP0003656_abnormal_erythrocyte_physiolo0.73710740
126MP0000639_abnormal_adrenal_gland0.73602194
127MP0003699_abnormal_female_reproductive0.73186605
128MP0002723_abnormal_immune_serum0.71678843
129MP0001919_abnormal_reproductive_system0.71183275
130MP0001340_abnormal_eyelid_morphology0.71150245
131MP0001145_abnormal_male_reproductive0.70614923
132MP0001845_abnormal_inflammatory_respons0.70333200
133MP0004264_abnormal_extraembryonic_tissu0.70322868
134MP0004782_abnormal_surfactant_physiolog0.70277367
135MP0008469_abnormal_protein_level0.69958455
136MP0005501_abnormal_skin_physiology0.69597981
137MP0000598_abnormal_liver_morphology0.69473219
138MP0002420_abnormal_adaptive_immunity0.69246410
139MP0001819_abnormal_immune_cell0.69183221
140MP0005365_abnormal_bile_salt0.67802390
141MP0001790_abnormal_immune_system0.66777631
142MP0005387_immune_system_phenotype0.66777631

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.81487967
2Rib fusion (HP:0000902)4.84760813
3Facial hemangioma (HP:0000329)4.81241936
4Poikiloderma (HP:0001029)4.75089199
5Increased IgM level (HP:0003496)4.74428072
6Rectovaginal fistula (HP:0000143)4.31890621
7Rectal fistula (HP:0100590)4.31890621
8Concave nail (HP:0001598)4.28518444
9Annular pancreas (HP:0001734)4.11180980
10Intestinal fistula (HP:0100819)4.10118546
11Microvesicular hepatic steatosis (HP:0001414)4.06861685
12Alopecia of scalp (HP:0002293)3.87674506
13Vaginal fistula (HP:0004320)3.87121416
14Turricephaly (HP:0000262)3.86385728
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.84077637
16Ulnar bowing (HP:0003031)3.82184759
17Hypochromic microcytic anemia (HP:0004840)3.69509583
18Tongue fasciculations (HP:0001308)3.57946286
19Squamous cell carcinoma (HP:0002860)3.51099749
20Absent radius (HP:0003974)3.31704843
21Abnormality of male internal genitalia (HP:0000022)3.30729225
22Intestinal atresia (HP:0011100)3.29579808
23Absent thumb (HP:0009777)3.22613838
24Basal cell carcinoma (HP:0002671)3.20911836
25Muscle fibrillation (HP:0010546)3.18834738
26Short humerus (HP:0005792)3.15703152
27Albinism (HP:0001022)3.14892579
28Premature ovarian failure (HP:0008209)3.14648880
29IgA deficiency (HP:0002720)3.12254668
30Aplasia/hypoplasia of the humerus (HP:0006507)3.10905516
31Absent forearm bone (HP:0003953)3.10558858
32Aplasia involving forearm bones (HP:0009822)3.10558858
33Aplastic anemia (HP:0001915)3.09131231
34Male infertility (HP:0003251)3.02954575
35Hypochromic anemia (HP:0001931)3.02521581
36Ragged-red muscle fibers (HP:0003200)3.00240926
37Rough bone trabeculation (HP:0100670)2.95099825
38Coronal craniosynostosis (HP:0004440)2.95056159
39Patellar aplasia (HP:0006443)2.91200980
40Orthostatic hypotension (HP:0001278)2.88369408
41Type I transferrin isoform profile (HP:0003642)2.85768365
42Anteriorly placed anus (HP:0001545)2.83549788
43Multiple enchondromatosis (HP:0005701)2.82415540
44Selective tooth agenesis (HP:0001592)2.81301370
45Cholecystitis (HP:0001082)2.80626570
46Abnormal gallbladder physiology (HP:0012438)2.80626570
47Premature graying of hair (HP:0002216)2.80329993
48Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.79863166
49Vertebral hypoplasia (HP:0008417)2.79863166
50Mucopolysacchariduria (HP:0008155)2.78067952
51Urinary glycosaminoglycan excretion (HP:0003541)2.78067952
52Progressive muscle weakness (HP:0003323)2.76961655
53Broad alveolar ridges (HP:0000187)2.74681980
54Abnormal hemoglobin (HP:0011902)2.70586901
55Cortical dysplasia (HP:0002539)2.69314968
56Secondary amenorrhea (HP:0000869)2.68139802
57Combined immunodeficiency (HP:0005387)2.67844928
58Short chin (HP:0000331)2.65472200
59Aplasia/Hypoplasia of the patella (HP:0006498)2.64563369
60Entropion (HP:0000621)2.63380168
61Pancreatic islet-cell hyperplasia (HP:0004510)2.57934077
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55877262
63Abnormality of polysaccharide metabolism (HP:0011012)2.55877262
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55877262
65Agammaglobulinemia (HP:0004432)2.54689020
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53271019
67Cellular immunodeficiency (HP:0005374)2.52473773
68Pelvic girdle muscle weakness (HP:0003749)2.51602450
69Volvulus (HP:0002580)2.51236094
70Severe combined immunodeficiency (HP:0004430)2.50648706
71Cerebral hypomyelination (HP:0006808)2.50619944
72Polycythemia (HP:0001901)2.50336780
73Dysautonomia (HP:0002459)2.49850712
74Increased intramyocellular lipid droplets (HP:0012240)2.49366127
75Hypoplastic pelvis (HP:0008839)2.47769314
76Abnormal number of incisors (HP:0011064)2.46659491
77Acute lymphatic leukemia (HP:0006721)2.46398677
78Shoulder girdle muscle weakness (HP:0003547)2.45955730
79Cutaneous melanoma (HP:0012056)2.45130762
80Congenital hip dislocation (HP:0001374)2.44948603
81Abnormality of DNA repair (HP:0003254)2.44907464
82Premature skin wrinkling (HP:0100678)2.43665319
83Fatigue (HP:0012378)2.43089142
84Hypotelorism (HP:0000601)2.42499861
85Premature loss of primary teeth (HP:0006323)2.41017463
86Colitis (HP:0002583)2.39912618
87Hypertensive crisis (HP:0100735)2.39343023
88Chromsome breakage (HP:0040012)2.38639623
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38523905
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38523905
91Dysostosis multiplex (HP:0000943)2.38464270
92Progressive external ophthalmoplegia (HP:0000590)2.36627167
93Pancytopenia (HP:0001876)2.35290855
94Abnormal trabecular bone morphology (HP:0100671)2.34747770
95Bifid uvula (HP:0000193)2.31226162
96Growth hormone excess (HP:0000845)2.30972997
97Large for gestational age (HP:0001520)2.30732212
98Alacrima (HP:0000522)2.30225354
99Capillary hemangiomas (HP:0005306)2.29443407
100Cerebral aneurysm (HP:0004944)2.27638149
101Respiratory difficulties (HP:0002880)2.26269867
102Joint stiffness (HP:0001387)2.26249350
103Aplasia/Hypoplasia of the thymus (HP:0010515)2.26242844
104Cheilitis (HP:0100825)2.25094236
105Abnormal protein glycosylation (HP:0012346)2.24610837
106Abnormal glycosylation (HP:0012345)2.24610837
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24610837
108Abnormal protein N-linked glycosylation (HP:0012347)2.24610837
109Increased hepatocellular lipid droplets (HP:0006565)2.24403546
110Diaphragmatic weakness (HP:0009113)2.22561869
111Reticulocytopenia (HP:0001896)2.22324477
112Increased muscle lipid content (HP:0009058)2.22088383
113Hamartoma (HP:0010566)2.20510871
114Hypotrichosis (HP:0001006)2.20354335
115Lymphopenia (HP:0001888)2.18718106
116Spinal muscular atrophy (HP:0007269)2.16976255
117Verrucae (HP:0200043)2.15176887
118Papilloma (HP:0012740)2.15176887
119Hepatosplenomegaly (HP:0001433)2.14355469
120Abnormality of the musculature of the pelvis (HP:0001469)2.13056266
121Abnormality of the hip-girdle musculature (HP:0001445)2.13056266
122Abnormality of the aortic arch (HP:0012303)2.12978512
123Obstructive lung disease (HP:0006536)2.11297717
124Chronic obstructive pulmonary disease (HP:0006510)2.11297717
125Abnormality of T cell physiology (HP:0011840)2.10915433
126Seborrheic dermatitis (HP:0001051)2.09843059
127Vertebral fusion (HP:0002948)2.09696412
128Oral leukoplakia (HP:0002745)2.09626432
129Myelodysplasia (HP:0002863)2.08000508
130IgG deficiency (HP:0004315)2.06850430
131Increased number of teeth (HP:0011069)2.06373540
132Abnormality of cells of the lymphoid lineage (HP:0012140)2.06107287
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05810486
134Lymphoma (HP:0002665)2.05178179
135Bowing of the arm (HP:0006488)2.04029186
136Bowed forearm bones (HP:0003956)2.04029186
137Mediastinal lymphadenopathy (HP:0100721)2.03677022
138Bone marrow hypocellularity (HP:0005528)2.03340512
139Aplasia of the musculature (HP:0100854)2.02572766
140Hypergonadotropic hypogonadism (HP:0000815)2.02532430
141Increased serum lactate (HP:0002151)2.01753410
142Short thumb (HP:0009778)2.01095232
143Abnormality of the ileum (HP:0001549)2.00195813
144Abnormality of the astrocytes (HP:0100707)1.98973820
145Astrocytoma (HP:0009592)1.98973820
146Abnormality of reticulocytes (HP:0004312)1.98907360
147Abnormality of the preputium (HP:0100587)1.98562399
148Gastrointestinal atresia (HP:0002589)1.97959478
149Lipid accumulation in hepatocytes (HP:0006561)1.97471359
150Hypoplasia of the radius (HP:0002984)1.94906964
151Horseshoe kidney (HP:0000085)1.94598900
152IgM deficiency (HP:0002850)1.94395674
153Neoplasm of the oral cavity (HP:0100649)1.93444766
154Recurrent viral infections (HP:0004429)1.92955368
155Upper limb muscle weakness (HP:0003484)1.92657618
156Death in infancy (HP:0001522)1.91607157
157Athetosis (HP:0002305)1.91047931
158Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90240016
159Myocardial infarction (HP:0001658)1.89415533
160Gastrointestinal inflammation (HP:0004386)1.89187964
161Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89113504
162Abnormality of cells of the erythroid lineage (HP:0012130)1.88991614
163Split hand (HP:0001171)1.88957315
164Inflammation of the large intestine (HP:0002037)1.88403045
165Reticulocytosis (HP:0001923)1.87815042
166Proximal placement of thumb (HP:0009623)1.87766717
167Recurrent fungal infections (HP:0002841)1.87733625
168Muscle fiber atrophy (HP:0100295)1.87695125
169Cutaneous photosensitivity (HP:0000992)1.85508100
170Lower limb hyperreflexia (HP:0002395)1.84657759
171Pallor (HP:0000980)1.83609825
172Abnormality of the pancreatic islet cells (HP:0006476)1.83031017
173Abnormality of endocrine pancreas physiology (HP:0012093)1.83031017
174Choanal stenosis (HP:0000452)1.82918050
175Neoplasm of the pancreas (HP:0002894)1.82262826
176Granulocytopenia (HP:0001913)1.81518049
177Abnormal number of erythroid precursors (HP:0012131)1.80851195
178Clumsiness (HP:0002312)1.80513098
179Abnormality of the labia minora (HP:0012880)1.80441325
180Bulbar palsy (HP:0001283)1.79931798
181Teleangiectasia of the skin (HP:0100585)1.76291761
182Achilles tendon contracture (HP:0001771)1.74834505
183Optic nerve coloboma (HP:0000588)1.73187931
184Abnormality of glycolysis (HP:0004366)1.73167595
185Neutropenia (HP:0001875)1.72336063
186Increased serum pyruvate (HP:0003542)1.72227523
187Abnormality of T cells (HP:0002843)1.71879150
188Deep palmar crease (HP:0006191)1.71263969
189Dysphonia (HP:0001618)1.69983589
190Trismus (HP:0000211)1.69805824
191Cholelithiasis (HP:0001081)1.69752755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.42617399
2MAPK154.43954550
3MAP3K64.26349809
4DDR24.03222715
5SRPK13.51905072
6TESK23.46894144
7PBK3.34476159
8MAP3K113.28002242
9PINK12.78955559
10MATK2.69802917
11FGR2.65869708
12PIM22.47099841
13TYRO32.43579071
14YES12.42090776
15CSK2.38989433
16BMX2.18326755
17DAPK12.04181108
18PRKD22.01540248
19UHMK11.98885538
20MAP3K101.98089095
21DYRK1B1.91838618
22CDK71.88794720
23PIM11.85698717
24BCKDK1.81745908
25SCYL21.81151005
26VRK21.73815579
27PDGFRA1.67137285
28SIK31.62452063
29TRPM71.62227366
30EIF2AK11.60434987
31CDK61.52208437
32MAP3K131.44083937
33MAP4K11.43944408
34NME11.36311466
35RPS6KC11.34851856
36RPS6KL11.34851856
37KDR1.31368168
38TSSK61.30771087
39NEK11.30430184
40DYRK31.30295793
41MAP3K141.29783652
42NEK21.29741483
43PDK21.27691856
44CHEK21.25280239
45RPS6KA61.23641482
46CDK121.23137711
47AKT31.22335980
48MAPK111.22156074
49TESK11.21900642
50MAP3K81.18077940
51IRAK31.16108861
52MAP2K31.15590381
53ERN11.12035153
54RPS6KA41.11587672
55CDK191.10741676
56MAP2K21.10420767
57IRAK41.09863279
58SMG11.09334474
59CLK11.08954690
60ATR1.04679084
61PLK11.01350181
62BCR1.00979423
63GSK3A1.00170657
64CDK80.99412733
65MAP2K70.98935038
66ARAF0.95430889
67PAK40.92060026
68MST1R0.91590466
69MARK30.90613238
70HIPK20.89431043
71TBK10.88490601
72TAOK20.82579263
73CDC42BPA0.82489379
74RPS6KA10.81462637
75CDC70.80494319
76MTOR0.80469304
77IKBKE0.75916365
78LATS20.73869059
79CDK40.73728341
80BRAF0.70767363
81IKBKB0.70284913
82FES0.69717393
83LYN0.69413343
84MST40.68963555
85PAK10.67521694
86ERBB40.66024397
87EPHB10.64415808
88VRK10.64377308
89PRPF4B0.63835689
90PLK40.62520670
91EIF2AK30.62398783
92STK30.61981895
93CSNK1A1L0.61920283
94CDK20.61003512
95STK100.60671667
96TRIB30.60017073
97NME20.59650881
98MOS0.59562597
99PRKAA10.58490024
100CSNK1G30.57984910
101AURKB0.57836253
102BUB10.57823298
103CCNB10.57532969
104WEE10.57499423
105RPS6KB20.56007274
106SIK20.55224596
107CHEK10.54230360
108RIPK40.53918631
109EIF2AK20.53353845
110BLK0.49732206
111TTK0.49321473
112CHUK0.49282765
113LCK0.49207771
114ALK0.47689354
115ZAP700.47502593
116MAP3K50.47439038
117TNK20.47039565
118ATM0.46468111
119TYK20.46209234
120FGFR40.45958298
121EGFR0.45866048
122CSNK2A10.44869618
123RPS6KB10.44506370
124PDGFRB0.43972517
125TRIM280.43639574
126MAPK30.43367710
127BRSK10.43069947
128FLT30.42483810
129MAPKAPK20.41097817
130MAPK10.40685732
131AURKA0.40153355
132MAPK40.39915870
133RAF10.39857527
134JAK30.39532131
135DYRK20.38130764
136MAPK140.33852940
137CDK10.32086244
138CSNK2A20.31660251
139TAOK10.30670029
140TLK10.30179437
141BRD40.29811728
142BTK0.28994332
143STK40.28873421
144EEF2K0.28655125
145CSNK1G10.28208291
146TXK0.27507194
147GRK60.26725638
148PHKG10.26201383
149PHKG20.26201383
150RIPK10.25626133
151PRKAA20.25609556
152ABL10.24844886
153MAPK100.24287441
154AKT10.23695586

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.81259045
2Base excision repair_Homo sapiens_hsa034104.52938357
3DNA replication_Homo sapiens_hsa030304.17446959
4Proteasome_Homo sapiens_hsa030503.82283724
5Fatty acid biosynthesis_Homo sapiens_hsa000613.71412466
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56740137
7Homologous recombination_Homo sapiens_hsa034402.47599732
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43533666
9Spliceosome_Homo sapiens_hsa030402.41023793
10Nucleotide excision repair_Homo sapiens_hsa034202.38156655
11Fanconi anemia pathway_Homo sapiens_hsa034602.21327923
12RNA transport_Homo sapiens_hsa030132.12502292
13Primary immunodeficiency_Homo sapiens_hsa053402.04813493
14mRNA surveillance pathway_Homo sapiens_hsa030151.99543592
15p53 signaling pathway_Homo sapiens_hsa041151.89920517
16Notch signaling pathway_Homo sapiens_hsa043301.78310876
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75910400
18Cell cycle_Homo sapiens_hsa041101.66689630
19Sulfur relay system_Homo sapiens_hsa041221.64351911
20mTOR signaling pathway_Homo sapiens_hsa041501.62586643
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.57140743
22Circadian rhythm_Homo sapiens_hsa047101.38336285
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29923270
24Hippo signaling pathway_Homo sapiens_hsa043901.26049927
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24312189
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22365422
27Arginine and proline metabolism_Homo sapiens_hsa003301.20905523
28Adherens junction_Homo sapiens_hsa045201.16320169
29Herpes simplex infection_Homo sapiens_hsa051681.16216120
30Folate biosynthesis_Homo sapiens_hsa007901.15674853
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.14607269
32Lysine degradation_Homo sapiens_hsa003101.14402884
33Parkinsons disease_Homo sapiens_hsa050121.13607841
34Shigellosis_Homo sapiens_hsa051311.13201855
35Steroid biosynthesis_Homo sapiens_hsa001001.10677353
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08891968
37Ribosome_Homo sapiens_hsa030101.08705878
38Hedgehog signaling pathway_Homo sapiens_hsa043401.07950508
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03618034
40Legionellosis_Homo sapiens_hsa051341.01411130
41Acute myeloid leukemia_Homo sapiens_hsa052210.98312465
42Chronic myeloid leukemia_Homo sapiens_hsa052200.95858068
43B cell receptor signaling pathway_Homo sapiens_hsa046620.95245496
44One carbon pool by folate_Homo sapiens_hsa006700.94063114
45TGF-beta signaling pathway_Homo sapiens_hsa043500.93897740
46Measles_Homo sapiens_hsa051620.93587954
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.93116265
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92977402
49Bladder cancer_Homo sapiens_hsa052190.92833183
50N-Glycan biosynthesis_Homo sapiens_hsa005100.91358716
51Biosynthesis of amino acids_Homo sapiens_hsa012300.91311005
52Colorectal cancer_Homo sapiens_hsa052100.89114877
53Viral myocarditis_Homo sapiens_hsa054160.85223410
54Oxidative phosphorylation_Homo sapiens_hsa001900.84312797
55Viral carcinogenesis_Homo sapiens_hsa052030.83566485
56Small cell lung cancer_Homo sapiens_hsa052220.83318770
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.81612273
58Pentose phosphate pathway_Homo sapiens_hsa000300.80941886
59MicroRNAs in cancer_Homo sapiens_hsa052060.80812448
60Carbon metabolism_Homo sapiens_hsa012000.80527453
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79392351
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.79364003
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79037869
64Allograft rejection_Homo sapiens_hsa053300.78451523
65Epstein-Barr virus infection_Homo sapiens_hsa051690.77949509
66VEGF signaling pathway_Homo sapiens_hsa043700.77662987
67Other glycan degradation_Homo sapiens_hsa005110.76245071
68Basal cell carcinoma_Homo sapiens_hsa052170.75787606
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75284470
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74648064
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73962476
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.73619966
73Wnt signaling pathway_Homo sapiens_hsa043100.73605211
74RNA polymerase_Homo sapiens_hsa030200.72565613
75RNA degradation_Homo sapiens_hsa030180.72042373
76Autoimmune thyroid disease_Homo sapiens_hsa053200.72016944
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71355659
78Purine metabolism_Homo sapiens_hsa002300.71222470
79Huntingtons disease_Homo sapiens_hsa050160.69694573
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69684398
81Hepatitis B_Homo sapiens_hsa051610.69511048
82Basal transcription factors_Homo sapiens_hsa030220.68908021
83HTLV-I infection_Homo sapiens_hsa051660.68050228
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67829689
85Galactose metabolism_Homo sapiens_hsa000520.67032835
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66157449
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65262975
88Pyrimidine metabolism_Homo sapiens_hsa002400.64234548
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63985256
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63530024
91Selenocompound metabolism_Homo sapiens_hsa004500.62259102
92Apoptosis_Homo sapiens_hsa042100.61925498
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60968548
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60405714
95Influenza A_Homo sapiens_hsa051640.59746314
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57309137
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57227612
98Fructose and mannose metabolism_Homo sapiens_hsa000510.55122560
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.54537152
100Hematopoietic cell lineage_Homo sapiens_hsa046400.54323839
101Oocyte meiosis_Homo sapiens_hsa041140.54137951
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52989218
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52898260
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.52328632
105Graft-versus-host disease_Homo sapiens_hsa053320.52030846
106Non-small cell lung cancer_Homo sapiens_hsa052230.50163588
107Antigen processing and presentation_Homo sapiens_hsa046120.49167144
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49075702
109Salmonella infection_Homo sapiens_hsa051320.48870792
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48830740
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48387850
112Protein export_Homo sapiens_hsa030600.48210964
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47526369
114TNF signaling pathway_Homo sapiens_hsa046680.46214358
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45436440
116Fatty acid metabolism_Homo sapiens_hsa012120.45352286
117Regulation of autophagy_Homo sapiens_hsa041400.45200409
118Fatty acid elongation_Homo sapiens_hsa000620.45184146
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43838051
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41722536
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41520412
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39397067
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.39388603
124Thyroid cancer_Homo sapiens_hsa052160.38980626
125Choline metabolism in cancer_Homo sapiens_hsa052310.38708175
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38104839
127Pancreatic cancer_Homo sapiens_hsa052120.38031232
128AMPK signaling pathway_Homo sapiens_hsa041520.37707966
129Non-homologous end-joining_Homo sapiens_hsa034500.37433649
130Dorso-ventral axis formation_Homo sapiens_hsa043200.36990965
131ErbB signaling pathway_Homo sapiens_hsa040120.36075538
132Systemic lupus erythematosus_Homo sapiens_hsa053220.35698003
133Leishmaniasis_Homo sapiens_hsa051400.33581158
134MAPK signaling pathway_Homo sapiens_hsa040100.31451006
135Prostate cancer_Homo sapiens_hsa052150.30988503
136Insulin signaling pathway_Homo sapiens_hsa049100.28932164
137T cell receptor signaling pathway_Homo sapiens_hsa046600.27826170
138Pathways in cancer_Homo sapiens_hsa052000.27791497
139Arginine biosynthesis_Homo sapiens_hsa002200.27197618
140Endometrial cancer_Homo sapiens_hsa052130.26326986
141Vitamin B6 metabolism_Homo sapiens_hsa007500.26065392
142Osteoclast differentiation_Homo sapiens_hsa043800.25751564

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