ACTR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.58488699
2ATP synthesis coupled proton transport (GO:0015986)5.19436427
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.19436427
4proteasome assembly (GO:0043248)5.01913431
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.83945491
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.71053031
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.71053031
8NADH dehydrogenase complex assembly (GO:0010257)4.71053031
9cullin deneddylation (GO:0010388)4.60422856
10protein neddylation (GO:0045116)4.57538474
11protein complex biogenesis (GO:0070271)4.49277008
12chaperone-mediated protein transport (GO:0072321)4.43303999
13DNA double-strand break processing (GO:0000729)4.22245068
14protein deneddylation (GO:0000338)4.20173952
15respiratory electron transport chain (GO:0022904)4.04804681
16mitochondrial respiratory chain complex assembly (GO:0033108)3.98914669
17electron transport chain (GO:0022900)3.95964681
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.77971279
197-methylguanosine mRNA capping (GO:0006370)3.77765627
207-methylguanosine RNA capping (GO:0009452)3.73586645
21RNA capping (GO:0036260)3.73586645
22termination of RNA polymerase III transcription (GO:0006386)3.67287482
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.67287482
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60558962
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.46731779
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43706538
27protein-cofactor linkage (GO:0018065)3.42233225
28neuron cell-cell adhesion (GO:0007158)3.39632735
29regulation of cellular amino acid metabolic process (GO:0006521)3.38827079
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38100488
31presynaptic membrane assembly (GO:0097105)3.38057366
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36067832
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32933793
34centriole replication (GO:0007099)3.29767713
35presynaptic membrane organization (GO:0097090)3.26731456
36negative regulation of ligase activity (GO:0051352)3.26110139
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26110139
38positive regulation of mitochondrial fission (GO:0090141)3.18748465
39resolution of meiotic recombination intermediates (GO:0000712)3.18194752
40protein targeting to mitochondrion (GO:0006626)3.16755314
41microtubule depolymerization (GO:0007019)3.16030580
42establishment of integrated proviral latency (GO:0075713)3.14533837
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11913853
44histone exchange (GO:0043486)3.11754522
45transcription elongation from RNA polymerase I promoter (GO:0006362)3.09837851
46establishment of protein localization to mitochondrion (GO:0072655)3.09540971
47intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07618910
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07618910
49rRNA modification (GO:0000154)3.06857934
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06319159
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06319159
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06319159
53CENP-A containing nucleosome assembly (GO:0034080)3.02475704
54GTP biosynthetic process (GO:0006183)3.01823124
55epithelial cilium movement (GO:0003351)3.00415659
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98778233
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.97981755
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97783465
59regulation of mitotic spindle checkpoint (GO:1903504)2.96380525
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96380525
61signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96365026
62signal transduction involved in DNA damage checkpoint (GO:0072422)2.96365026
63L-methionine salvage (GO:0071267)2.95184909
64L-methionine biosynthetic process (GO:0071265)2.95184909
65amino acid salvage (GO:0043102)2.95184909
66signal transduction involved in cell cycle checkpoint (GO:0072395)2.95116540
67platelet dense granule organization (GO:0060155)2.95033592
68purine nucleobase biosynthetic process (GO:0009113)2.94874313
69guanosine-containing compound biosynthetic process (GO:1901070)2.94193423
70regulation of mitochondrial translation (GO:0070129)2.92294027
71respiratory chain complex IV assembly (GO:0008535)2.91590691
72DNA deamination (GO:0045006)2.90549655
73organelle disassembly (GO:1903008)2.90457191
74deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.89624578
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89012157
76termination of RNA polymerase I transcription (GO:0006363)2.88113142
77positive regulation of ligase activity (GO:0051351)2.87814781
78protein localization to mitochondrion (GO:0070585)2.87516770
79response to pheromone (GO:0019236)2.87391989
80nonmotile primary cilium assembly (GO:0035058)2.87199751
81nucleobase biosynthetic process (GO:0046112)2.86647164
82chromatin remodeling at centromere (GO:0031055)2.86329640
83behavioral response to nicotine (GO:0035095)2.83718696
84ribonucleoprotein complex disassembly (GO:0032988)2.82859570
85maturation of 5.8S rRNA (GO:0000460)2.81771791
86GMP metabolic process (GO:0046037)2.80262202
87establishment of viral latency (GO:0019043)2.80085249
882-deoxyribonucleotide biosynthetic process (GO:0009265)2.78754822
89deoxyribose phosphate biosynthetic process (GO:0046385)2.78754822
90dopamine transport (GO:0015872)2.77298082
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76793953
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76793953
93microtubule polymerization or depolymerization (GO:0031109)2.76718083
94regulation of cilium movement (GO:0003352)2.76203292
95deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.76046811
96regulation of cellular amine metabolic process (GO:0033238)2.75465056
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75097464
98rRNA methylation (GO:0031167)2.74145597
99histone mRNA metabolic process (GO:0008334)2.74091358
100DNA ligation (GO:0006266)2.73754426
101purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73550703
102purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73448310
103intraciliary transport (GO:0042073)2.72498419
104replication fork processing (GO:0031297)2.71825121
105somite rostral/caudal axis specification (GO:0032525)2.71558929
106fatty acid elongation (GO:0030497)2.71486968
107positive regulation of protein homodimerization activity (GO:0090073)2.71313346
108mitotic metaphase plate congression (GO:0007080)2.71268141
109deoxyribonucleotide biosynthetic process (GO:0009263)2.71173202
110oxidative phosphorylation (GO:0006119)2.68738865
111metallo-sulfur cluster assembly (GO:0031163)2.68477115
112iron-sulfur cluster assembly (GO:0016226)2.68477115
113neurotransmitter uptake (GO:0001504)2.67904155
114protein localization to cilium (GO:0061512)2.67864954
115maturation of SSU-rRNA (GO:0030490)2.67675840
116pyrimidine nucleobase catabolic process (GO:0006208)2.67588001
117long-chain fatty acid biosynthetic process (GO:0042759)2.67187265
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66722368
119protein K11-linked ubiquitination (GO:0070979)2.65809305
120positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.65540881
121mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.65540881
122ATP biosynthetic process (GO:0006754)2.65341220
123transcription from RNA polymerase I promoter (GO:0006360)2.63864799
124DNA damage response, detection of DNA damage (GO:0042769)2.63862388
125DNA replication-independent nucleosome assembly (GO:0006336)2.63546711
126DNA replication-independent nucleosome organization (GO:0034724)2.63546711
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.63055185
128peptidyl-histidine modification (GO:0018202)2.62964249
129aerobic respiration (GO:0009060)2.62152337
130cytochrome complex assembly (GO:0017004)2.61062869
131behavioral response to ethanol (GO:0048149)2.59685766
132RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59515323
133anterograde synaptic vesicle transport (GO:0048490)2.58963947
134spliceosomal snRNP assembly (GO:0000387)2.58706668
135axoneme assembly (GO:0035082)2.58574252
136piRNA metabolic process (GO:0034587)2.57406615
137regulation of centriole replication (GO:0046599)2.57228579
138recombinational repair (GO:0000725)2.57158970
139DNA catabolic process, exonucleolytic (GO:0000738)2.55473310
140inner mitochondrial membrane organization (GO:0007007)2.54961273
141double-strand break repair via homologous recombination (GO:0000724)2.54080854
142cilium movement (GO:0003341)2.50543087
143retinal ganglion cell axon guidance (GO:0031290)2.49787945
144single strand break repair (GO:0000012)2.47160624
145GPI anchor metabolic process (GO:0006505)2.46589973
146mannosylation (GO:0097502)2.45883704
147water-soluble vitamin biosynthetic process (GO:0042364)2.45841070
148gamma-aminobutyric acid transport (GO:0015812)2.45452604
149intracellular protein transmembrane import (GO:0044743)2.45298381
150kinetochore organization (GO:0051383)2.44291169
151cilium organization (GO:0044782)2.44204263
152cilium morphogenesis (GO:0060271)2.43657034
153synapsis (GO:0007129)2.42950415
154cilium assembly (GO:0042384)2.42327825
155histone H2A acetylation (GO:0043968)2.41941776
156DNA integration (GO:0015074)2.41600055
157regulation of DNA endoreduplication (GO:0032875)2.40323120
158kinetochore assembly (GO:0051382)2.39267166
159nucleobase catabolic process (GO:0046113)2.36674113
160regulation of nuclear cell cycle DNA replication (GO:0033262)2.36022285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28355719
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.62462077
3* GABP_17652178_ChIP-ChIP_JURKAT_Human3.34654853
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.19531096
5ZNF274_21170338_ChIP-Seq_K562_Hela3.12819939
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03604766
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.82579134
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81558077
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80476900
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74598263
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60113443
12TAF15_26573619_Chip-Seq_HEK293_Human2.60051525
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.58497354
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50027657
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45697312
16GBX2_23144817_ChIP-Seq_PC3_Human2.44606300
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44167431
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31438328
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.28001810
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.20486900
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15562209
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14864031
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08267927
24FUS_26573619_Chip-Seq_HEK293_Human2.08148190
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04236560
26* SRF_21415370_ChIP-Seq_HL-1_Mouse1.97159404
27* VDR_23849224_ChIP-Seq_CD4+_Human1.93882165
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87641813
29EZH2_22144423_ChIP-Seq_EOC_Human1.86777924
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82500939
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81667581
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.77275735
33* ELK1_19687146_ChIP-ChIP_HELA_Human1.74827570
34* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73631881
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64585810
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64366960
37FOXP3_21729870_ChIP-Seq_TREG_Human1.63233243
38DCP1A_22483619_ChIP-Seq_HELA_Human1.62249374
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61364058
40EWS_26573619_Chip-Seq_HEK293_Human1.60983232
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60198626
42* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59113573
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58682268
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58057228
45VDR_22108803_ChIP-Seq_LS180_Human1.55711808
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53835990
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50447310
48IGF1R_20145208_ChIP-Seq_DFB_Human1.49615661
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48115187
50IRF1_19129219_ChIP-ChIP_H3396_Human1.47202595
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45008377
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44566639
53ER_23166858_ChIP-Seq_MCF-7_Human1.42221005
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.41931942
55E2F7_22180533_ChIP-Seq_HELA_Human1.40685149
56CBP_20019798_ChIP-Seq_JUKART_Human1.40196056
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40196056
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38758968
59P300_19829295_ChIP-Seq_ESCs_Human1.30587541
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29208034
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27508467
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26862536
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26756660
64TP53_22573176_ChIP-Seq_HFKS_Human1.26218935
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25761298
66MYC_18940864_ChIP-ChIP_HL60_Human1.23721719
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23611298
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23340721
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22500808
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22368189
71AR_21909140_ChIP-Seq_LNCAP_Human1.21176997
72TTF2_22483619_ChIP-Seq_HELA_Human1.20433277
73GABP_19822575_ChIP-Seq_HepG2_Human1.20362462
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20299422
75* SMAD4_21799915_ChIP-Seq_A2780_Human1.18298200
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18046387
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18042945
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17583485
79BCAT_22108803_ChIP-Seq_LS180_Human1.17575276
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.17480506
81* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16987703
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16812189
83RNF2_27304074_Chip-Seq_NSC_Mouse1.16687125
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16465647
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.16289380
86SOX2_19829295_ChIP-Seq_ESCs_Human1.16244776
87NANOG_19829295_ChIP-Seq_ESCs_Human1.16244776
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15716304
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14746203
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.13822998
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.12797530
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12630242
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.11956689
94HTT_18923047_ChIP-ChIP_STHdh_Human1.10368644
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09663342
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09403665
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08773861
98TCF4_22108803_ChIP-Seq_LS180_Human1.08645635
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08343877
100AR_25329375_ChIP-Seq_VCAP_Human1.07568143
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07492021
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07345256
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.07345256
104XRN2_22483619_ChIP-Seq_HELA_Human1.07187203
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06290143
106SOX2_16153702_ChIP-ChIP_HESCs_Human1.05979823
107* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05876037
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.05583218
109* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05512336
110JUN_21703547_ChIP-Seq_K562_Human1.05182108
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04508196
112STAT3_23295773_ChIP-Seq_U87_Human1.04489590
113REST_21632747_ChIP-Seq_MESCs_Mouse1.03035512
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02108553
115* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01573220
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01329793
117TCF4_23295773_ChIP-Seq_U87_Human1.01234568
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99805056
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99805056
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.98991953
121TAL1_26923725_Chip-Seq_HPCs_Mouse0.98881678
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96735860
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96236955
124STAT3_18555785_Chip-Seq_ESCs_Mouse0.96024528
125SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95874747
126P300_18555785_Chip-Seq_ESCs_Mouse0.94751334
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94284210
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93466168
129E2F1_18555785_Chip-Seq_ESCs_Mouse0.93392660
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93378273
131P53_22387025_ChIP-Seq_ESCs_Mouse0.92639787
132RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92166641
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92086510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.24942332
2MP0001529_abnormal_vocalization3.41512299
3MP0002736_abnormal_nociception_after2.77381724
4MP0001968_abnormal_touch/_nociception2.66143693
5MP0001905_abnormal_dopamine_level2.59086027
6MP0001986_abnormal_taste_sensitivity2.49245919
7MP0001188_hyperpigmentation2.42664461
8MP0006072_abnormal_retinal_apoptosis2.35792066
9MP0003890_abnormal_embryonic-extraembry2.27282422
10MP0009046_muscle_twitch2.25171336
11MP0002735_abnormal_chemical_nociception2.24242031
12MP0005423_abnormal_somatic_nervous2.17542904
13MP0002272_abnormal_nervous_system2.16754802
14MP0008877_abnormal_DNA_methylation2.16170253
15MP0009745_abnormal_behavioral_response2.13675445
16MP0006276_abnormal_autonomic_nervous2.13663969
17MP0009697_abnormal_copulation2.08703191
18MP0003806_abnormal_nucleotide_metabolis2.07482673
19MP0008058_abnormal_DNA_repair2.06107867
20MP0004142_abnormal_muscle_tone2.05311162
21MP0003718_maternal_effect1.99790323
22MP0003635_abnormal_synaptic_transmissio1.99263713
23MP0002064_seizures1.99026173
24MP0006292_abnormal_olfactory_placode1.96373228
25MP0004270_analgesia1.95936393
26MP0003136_yellow_coat_color1.87208327
27MP0002734_abnormal_mechanical_nocicepti1.86500617
28MP0000516_abnormal_urinary_system1.84931355
29MP0005367_renal/urinary_system_phenotyp1.84931355
30MP0002572_abnormal_emotion/affect_behav1.81911550
31MP0008057_abnormal_DNA_replication1.80085378
32MP0001440_abnormal_grooming_behavior1.74641044
33MP0002876_abnormal_thyroid_physiology1.69996105
34MP0001486_abnormal_startle_reflex1.66074928
35MP0000569_abnormal_digit_pigmentation1.63825294
36MP0002063_abnormal_learning/memory/cond1.61980985
37MP0002067_abnormal_sensory_capabilities1.56721999
38MP0005551_abnormal_eye_electrophysiolog1.54695527
39MP0010094_abnormal_chromosome_stability1.53964288
40MP0003011_delayed_dark_adaptation1.53746890
41MP0004957_abnormal_blastocyst_morpholog1.53074756
42MP0002837_dystrophic_cardiac_calcinosis1.51324382
43MP0001984_abnormal_olfaction1.49741309
44MP0003879_abnormal_hair_cell1.49183410
45MP0006035_abnormal_mitochondrial_morpho1.49067801
46MP0002234_abnormal_pharynx_morphology1.48863288
47MP0008260_abnormal_autophagy1.48396979
48MP0004147_increased_porphyrin_level1.47500403
49MP0006036_abnormal_mitochondrial_physio1.45755476
50MP0003121_genomic_imprinting1.44367427
51MP0003123_paternal_imprinting1.44009642
52MP0004133_heterotaxia1.43402423
53MP0009379_abnormal_foot_pigmentation1.41604347
54MP0004859_abnormal_synaptic_plasticity1.40719343
55MP0005386_behavior/neurological_phenoty1.39798945
56MP0004924_abnormal_behavior1.39798945
57MP0008789_abnormal_olfactory_epithelium1.39575793
58MP0002751_abnormal_autonomic_nervous1.36685395
59MP0002102_abnormal_ear_morphology1.35801202
60MP0000566_synostosis1.32183524
61MP0005645_abnormal_hypothalamus_physiol1.32133191
62MP0008932_abnormal_embryonic_tissue1.29686002
63MP0002638_abnormal_pupillary_reflex1.26478979
64MP0001970_abnormal_pain_threshold1.25306049
65MP0004885_abnormal_endolymph1.24103036
66MP0001764_abnormal_homeostasis1.23325723
67MP0003186_abnormal_redox_activity1.21715845
68MP0003693_abnormal_embryo_hatching1.20814379
69MP0002184_abnormal_innervation1.20744249
70MP0001963_abnormal_hearing_physiology1.19958508
71MP0005499_abnormal_olfactory_system1.18699244
72MP0005394_taste/olfaction_phenotype1.18699244
73MP0001485_abnormal_pinna_reflex1.18154407
74MP0002733_abnormal_thermal_nociception1.17213150
75MP0003122_maternal_imprinting1.15848211
76MP0008995_early_reproductive_senescence1.15113194
77MP0000778_abnormal_nervous_system1.13794497
78MP0003111_abnormal_nucleus_morphology1.09677514
79MP0003787_abnormal_imprinting1.09390149
80MP0008872_abnormal_physiological_respon1.07846909
81MP0000026_abnormal_inner_ear1.07747879
82MP0003567_abnormal_fetal_cardiomyocyte1.07614958
83MP0003938_abnormal_ear_development1.06980262
84MP0003195_calcinosis1.06484354
85MP0005410_abnormal_fertilization1.06338794
86MP0004215_abnormal_myocardial_fiber1.06168704
87MP0000647_abnormal_sebaceous_gland1.04993641
88MP0002653_abnormal_ependyma_morphology1.03465295
89MP0000631_abnormal_neuroendocrine_gland1.03091279
90MP0003950_abnormal_plasma_membrane1.02882986
91MP0002210_abnormal_sex_determination1.02664251
92MP0003119_abnormal_digestive_system1.02109750
93MP0002557_abnormal_social/conspecific_i1.02033328
94MP0003077_abnormal_cell_cycle1.01855672
95MP0003698_abnormal_male_reproductive1.01289401
96MP0005646_abnormal_pituitary_gland1.01215727
97MP0001929_abnormal_gametogenesis1.00654191
98MP0004742_abnormal_vestibular_system1.00184252
99MP0008007_abnormal_cellular_replicative0.99597256
100MP0001501_abnormal_sleep_pattern0.98311058
101MP0003786_premature_aging0.98280414
102MP0005171_absent_coat_pigmentation0.97888870
103MP0002752_abnormal_somatic_nervous0.96510678
104MP0002229_neurodegeneration0.96502920
105MP0003315_abnormal_perineum_morphology0.96269788
106MP0001293_anophthalmia0.95544448
107MP0002066_abnormal_motor_capabilities/c0.94668769
108MP0000920_abnormal_myelination0.91381414
109MP0005084_abnormal_gallbladder_morpholo0.90902097
110MP0002163_abnormal_gland_morphology0.89901919
111MP0002882_abnormal_neuron_morphology0.89599611
112MP0002095_abnormal_skin_pigmentation0.89582754
113MP0005187_abnormal_penis_morphology0.87272234
114MP0002938_white_spotting0.84940628
115MP0002282_abnormal_trachea_morphology0.84588186
116MP0005391_vision/eye_phenotype0.84323490
117MP0005195_abnormal_posterior_eye0.84056095
118MP0000015_abnormal_ear_pigmentation0.82945164
119MP0005409_darkened_coat_color0.82196111
120MP0004134_abnormal_chest_morphology0.79549692
121MP0002822_catalepsy0.79292159
122MP0001145_abnormal_male_reproductive0.78872571
123MP0000955_abnormal_spinal_cord0.78031722
124MP0003632_abnormal_nervous_system0.76891421
125MP0000653_abnormal_sex_gland0.75405005
126MP0002160_abnormal_reproductive_system0.75062715
127MP0004484_altered_response_of0.73842086
128MP0005253_abnormal_eye_physiology0.73658240
129MP0000372_irregular_coat_pigmentation0.73563757
130MP0001542_abnormal_bone_strength0.72672386

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.37301617
2Abnormal mitochondria in muscle tissue (HP:0008316)4.81743500
3Mitochondrial inheritance (HP:0001427)4.66485888
4Progressive macrocephaly (HP:0004481)4.50766825
5Acute encephalopathy (HP:0006846)4.28457992
6Increased CSF lactate (HP:0002490)4.12423377
7Increased serum pyruvate (HP:0003542)3.84673394
8Abnormality of glycolysis (HP:0004366)3.84673394
9Hepatocellular necrosis (HP:0001404)3.78690360
10Increased hepatocellular lipid droplets (HP:0006565)3.68008796
113-Methylglutaconic aciduria (HP:0003535)3.64902189
12Pancreatic cysts (HP:0001737)3.35703318
13Abnormality of midbrain morphology (HP:0002418)3.30220347
14Molar tooth sign on MRI (HP:0002419)3.30220347
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.22337244
16Focal motor seizures (HP:0011153)3.19573586
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.13450221
18Epileptic encephalopathy (HP:0200134)3.11802084
19Lipid accumulation in hepatocytes (HP:0006561)3.11323278
20Optic disc pallor (HP:0000543)3.05817028
21Renal Fanconi syndrome (HP:0001994)3.04135233
22Leukodystrophy (HP:0002415)2.93675605
23Cerebral edema (HP:0002181)2.93588099
24Medial flaring of the eyebrow (HP:0010747)2.91744047
25Birth length less than 3rd percentile (HP:0003561)2.90964043
26Hepatic necrosis (HP:0002605)2.90830000
27Cerebral hypomyelination (HP:0006808)2.89971445
28Gait imbalance (HP:0002141)2.89549195
29Nephronophthisis (HP:0000090)2.84464689
30Increased serum lactate (HP:0002151)2.82551710
31Exercise intolerance (HP:0003546)2.79763634
32Lactic acidosis (HP:0003128)2.79598110
33Congenital primary aphakia (HP:0007707)2.74062946
34Irregular epiphyses (HP:0010582)2.70970710
35Intestinal atresia (HP:0011100)2.69585449
36Atonic seizures (HP:0010819)2.69246347
37Delusions (HP:0000746)2.67927822
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67016298
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67016298
40Respiratory failure (HP:0002878)2.66430260
41Nephrogenic diabetes insipidus (HP:0009806)2.64192182
42Hyperventilation (HP:0002883)2.58580477
43Volvulus (HP:0002580)2.52363269
44Type II lissencephaly (HP:0007260)2.51290205
45Abnormal hair whorl (HP:0010721)2.41137076
46Increased intramyocellular lipid droplets (HP:0012240)2.39734848
47Abnormality of the labia minora (HP:0012880)2.39161206
48Abnormality of the renal medulla (HP:0100957)2.35084295
49Gonadotropin excess (HP:0000837)2.31216365
50Pancreatic fibrosis (HP:0100732)2.28651308
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.28597153
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.28478223
53Short tibia (HP:0005736)2.27853589
54Median cleft lip (HP:0000161)2.26919777
55Lissencephaly (HP:0001339)2.26340985
56Genital tract atresia (HP:0001827)2.25370127
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.25005665
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.25005665
59Parakeratosis (HP:0001036)2.22856577
60CNS demyelination (HP:0007305)2.20354403
61Colon cancer (HP:0003003)2.19949152
62Abolished electroretinogram (ERG) (HP:0000550)2.19062082
63Respiratory difficulties (HP:0002880)2.18865841
64Abnormal lung lobation (HP:0002101)2.16561892
65Retinal dysplasia (HP:0007973)2.14703353
66Poor coordination (HP:0002370)2.14410441
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.13205044
68X-linked dominant inheritance (HP:0001423)2.12420102
69Vaginal atresia (HP:0000148)2.12014194
70Microvesicular hepatic steatosis (HP:0001414)2.11465710
71Failure to thrive in infancy (HP:0001531)2.11055993
72Emotional lability (HP:0000712)2.10898440
73Exertional dyspnea (HP:0002875)2.10241616
74Febrile seizures (HP:0002373)2.08560858
75Absent/shortened dynein arms (HP:0200106)2.08450189
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.08450189
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.07441204
78CNS hypomyelination (HP:0003429)2.06907959
79Unsteady gait (HP:0002317)2.06619170
80Abnormality of the ileum (HP:0001549)2.05287125
81Neuroendocrine neoplasm (HP:0100634)2.04394684
82Abnormality of alanine metabolism (HP:0010916)2.02926839
83Hyperalaninemia (HP:0003348)2.02926839
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02926839
85Abnormality of the renal cortex (HP:0011035)2.02253804
86Meckel diverticulum (HP:0002245)2.01968104
87Abnormal respiratory motile cilium physiology (HP:0012261)2.01942331
88Poor suck (HP:0002033)2.01050593
89Congenital, generalized hypertrichosis (HP:0004540)2.00994699
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.98270377
91Carpal bone hypoplasia (HP:0001498)1.94245563
92Abnormality of macular pigmentation (HP:0008002)1.93746788
93Sclerocornea (HP:0000647)1.93652444
94Gastrointestinal atresia (HP:0002589)1.92445397
95Abnormality of chromosome stability (HP:0003220)1.92012563
96Hypothermia (HP:0002045)1.91331156
97Inability to walk (HP:0002540)1.91237023
98Abnormal respiratory epithelium morphology (HP:0012253)1.90644085
99Abnormal respiratory motile cilium morphology (HP:0005938)1.90644085
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90523598
101Limb dystonia (HP:0002451)1.89083351
102True hermaphroditism (HP:0010459)1.88461341
103Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87711855
104Absent epiphyses (HP:0010577)1.87711855
105Abnormality of serum amino acid levels (HP:0003112)1.87536250
106Supernumerary spleens (HP:0009799)1.85370962
107Postaxial hand polydactyly (HP:0001162)1.85024729
108Chronic hepatic failure (HP:0100626)1.84753398
109Split foot (HP:0001839)1.84024878
110Progressive external ophthalmoplegia (HP:0000590)1.83694147
111Postaxial foot polydactyly (HP:0001830)1.83553364
112Sloping forehead (HP:0000340)1.83201817
113Rhinitis (HP:0012384)1.81854872
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81818353
115Abnormality of renal resorption (HP:0011038)1.81602379
116Esotropia (HP:0000565)1.80198999
117Optic nerve hypoplasia (HP:0000609)1.79980018
118Small intestinal stenosis (HP:0012848)1.78677322
119Duodenal stenosis (HP:0100867)1.78677322
120Cerebellar dysplasia (HP:0007033)1.77865398
121Bile duct proliferation (HP:0001408)1.77602866
122Abnormal biliary tract physiology (HP:0012439)1.77602866
123Methylmalonic acidemia (HP:0002912)1.77399188
124Hyperglycinemia (HP:0002154)1.77082201
125Hypoplasia of the pons (HP:0012110)1.76511906
126Abnormality of the pons (HP:0007361)1.76388805
127Breast hypoplasia (HP:0003187)1.76119659
128Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75972197
129Sensory axonal neuropathy (HP:0003390)1.74381046
130Renal cortical cysts (HP:0000803)1.74284853
131Specific learning disability (HP:0001328)1.74130940
132Hypoplastic left heart (HP:0004383)1.74061124
133Congenital stationary night blindness (HP:0007642)1.73630723
134Abnormality of the duodenum (HP:0002246)1.73531477
135Abnormality of the clitoris (HP:0000056)1.73274347
136Increased muscle lipid content (HP:0009058)1.71808434
137Triphalangeal thumb (HP:0001199)1.71513256
138Progressive inability to walk (HP:0002505)1.70703457
139Gaze-evoked nystagmus (HP:0000640)1.70430786
140Pheochromocytoma (HP:0002666)1.69837554
141Autoamputation (HP:0001218)1.69444670
142Lethargy (HP:0001254)1.69203513
143Abnormality of methionine metabolism (HP:0010901)1.69135641
144Type 2 muscle fiber atrophy (HP:0003554)1.69122801
145Dyschromatopsia (HP:0007641)1.68489487
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67866029
147Abnormality of the corticospinal tract (HP:0002492)1.67741137
148Cystic liver disease (HP:0006706)1.67734528
149Dialeptic seizures (HP:0011146)1.66958679
150Anencephaly (HP:0002323)1.66232038
151Broad-based gait (HP:0002136)1.66109357
152Abnormal ciliary motility (HP:0012262)1.64563890
153Methylmalonic aciduria (HP:0012120)1.63159183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.54695853
2STK162.68500337
3BUB12.65852839
4CCNB12.60991228
5WEE12.58797063
6PBK2.52022506
7PNCK2.40170115
8TAF12.39924107
9TRIM282.34274660
10MAP3K122.25083329
11NUAK12.21838063
12MUSK2.20845471
13FRK2.19418866
14MAP4K22.12611064
15EIF2AK12.11449600
16NME12.10337274
17MST42.07559193
18SRPK12.07129541
19MAP2K72.05017651
20TSSK61.92271303
21ERBB31.89592648
22CDK191.86417711
23OXSR11.83503434
24TNIK1.82894442
25VRK21.73670562
26EIF2AK31.73084034
27EPHA41.70339729
28PRPF4B1.70091146
29MKNK11.63638628
30PLK21.51009890
31MKNK21.44861254
32BRSK21.42518356
33MARK11.42516493
34PLK31.41845565
35STK391.40008836
36BCR1.38632926
37BMPR1B1.36614694
38NTRK31.36007903
39PDK31.32949174
40PDK41.32949174
41VRK11.32922267
42MAP3K41.22119307
43PINK11.15953339
44PDK21.11103185
45TTK1.10973910
46DYRK21.07431691
47DAPK11.07418349
48CDK81.06240798
49MAPK131.00015573
50PASK0.99217020
51AKT30.98644491
52CSNK1G30.98356592
53NEK10.97507634
54DYRK30.96976811
55ZAK0.96562627
56CDC70.96547707
57BMPR20.91973956
58NEK60.91915715
59WNK40.91732484
60GRK50.91538063
61PLK10.88366707
62ADRBK20.87219481
63PAK30.86306151
64ACVR1B0.86005465
65INSRR0.85705875
66MYLK0.83223263
67ARAF0.81786701
68SIK30.81470652
69ATR0.78658424
70PLK40.78346017
71CAMK2B0.74141529
72CSNK1G20.72025978
73MINK10.71767170
74PRKCG0.71347330
75NTRK20.71232363
76CAMK2A0.68971250
77BRSK10.68223066
78WNK30.67597113
79CSNK1G10.66766488
80RPS6KA40.66295766
81MAPKAPK50.66057405
82TLK10.63826185
83EIF2AK20.63720804
84DYRK1A0.63712925
85BRAF0.61929077
86BCKDK0.60439976
87CAMKK20.59685866
88PKN10.59149087
89CDK30.57195268
90CDK180.56878259
91AURKA0.54578319
92TXK0.54477073
93CDK140.54379154
94GRK70.53765889
95CSNK1A1L0.53485069
96ATM0.53367122
97UHMK10.53358332
98CDK150.50446457
99YES10.50282462
100CHEK20.48444320
101AURKB0.44948172
102CDK11A0.44825785
103ERBB40.44383920
104CSNK1E0.42761339
105CSNK2A10.42581582
106NME20.42236598
107CSNK2A20.40798528
108CDK50.40668597
109STK38L0.39480888
110TAOK30.38700163
111MAPK40.38628332
112GRK10.38409631
113PRKCE0.37719707
114OBSCN0.36791316
115PRKACB0.36396269
116STK240.36302846
117PRKACA0.36249488
118MAP2K40.36008903
119SGK4940.35898481
120SGK2230.35898481
121STK30.34732381
122RPS6KA50.34422974
123CSNK1A10.34242157
124CAMK2D0.34215817
125LIMK10.33693487
126MAP3K50.33449875
127TGFBR10.32262742
128MAP3K60.31666025
129CLK10.30762116
130PHKG20.30415533

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.35854470
2Proteasome_Homo sapiens_hsa030504.08524242
3Parkinsons disease_Homo sapiens_hsa050123.60026526
4RNA polymerase_Homo sapiens_hsa030203.36006725
5Huntingtons disease_Homo sapiens_hsa050162.73262168
6Alzheimers disease_Homo sapiens_hsa050102.70446684
7Protein export_Homo sapiens_hsa030602.58614571
8Ribosome_Homo sapiens_hsa030102.51254752
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49324385
10Basal transcription factors_Homo sapiens_hsa030222.29543534
11Nicotine addiction_Homo sapiens_hsa050332.23279062
12Collecting duct acid secretion_Homo sapiens_hsa049662.06709307
13Pyrimidine metabolism_Homo sapiens_hsa002401.96847720
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91042716
15Phototransduction_Homo sapiens_hsa047441.76360206
16Spliceosome_Homo sapiens_hsa030401.75038591
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73680095
18Nucleotide excision repair_Homo sapiens_hsa034201.71283609
19Vitamin B6 metabolism_Homo sapiens_hsa007501.69561619
20DNA replication_Homo sapiens_hsa030301.61870615
21Mismatch repair_Homo sapiens_hsa034301.59467283
22RNA transport_Homo sapiens_hsa030131.57041559
23Fatty acid elongation_Homo sapiens_hsa000621.56856377
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52425538
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52063269
26Purine metabolism_Homo sapiens_hsa002301.45777922
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44545422
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39340228
29Cardiac muscle contraction_Homo sapiens_hsa042601.39092639
30Synaptic vesicle cycle_Homo sapiens_hsa047211.38313124
31Fanconi anemia pathway_Homo sapiens_hsa034601.33842650
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32557467
33Homologous recombination_Homo sapiens_hsa034401.29628761
34RNA degradation_Homo sapiens_hsa030181.23240267
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21039636
36Nitrogen metabolism_Homo sapiens_hsa009101.19768256
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19271023
38Non-homologous end-joining_Homo sapiens_hsa034501.17598301
39Caffeine metabolism_Homo sapiens_hsa002321.16852894
40Steroid biosynthesis_Homo sapiens_hsa001001.13218202
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10347939
42GABAergic synapse_Homo sapiens_hsa047271.09263012
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04728193
44Vibrio cholerae infection_Homo sapiens_hsa051101.03627212
45Cell cycle_Homo sapiens_hsa041101.02370839
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99849709
47Base excision repair_Homo sapiens_hsa034100.96305356
48Oocyte meiosis_Homo sapiens_hsa041140.96291220
49Sulfur metabolism_Homo sapiens_hsa009200.93467146
50Pyruvate metabolism_Homo sapiens_hsa006200.93310514
51Selenocompound metabolism_Homo sapiens_hsa004500.92843579
52Serotonergic synapse_Homo sapiens_hsa047260.91533180
53Morphine addiction_Homo sapiens_hsa050320.91228071
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.88999150
55Tryptophan metabolism_Homo sapiens_hsa003800.88049464
56Ether lipid metabolism_Homo sapiens_hsa005650.86093223
57Taste transduction_Homo sapiens_hsa047420.85938770
58Metabolic pathways_Homo sapiens_hsa011000.85681522
59Linoleic acid metabolism_Homo sapiens_hsa005910.84873222
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.83818279
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83274194
62Regulation of autophagy_Homo sapiens_hsa041400.82259524
63beta-Alanine metabolism_Homo sapiens_hsa004100.78276807
64Circadian rhythm_Homo sapiens_hsa047100.75012034
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74957639
66Glutamatergic synapse_Homo sapiens_hsa047240.74014878
67mRNA surveillance pathway_Homo sapiens_hsa030150.73863303
68Amphetamine addiction_Homo sapiens_hsa050310.73032115
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72198858
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71685327
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65114064
72Olfactory transduction_Homo sapiens_hsa047400.64935935
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64189208
74Circadian entrainment_Homo sapiens_hsa047130.63254648
75Rheumatoid arthritis_Homo sapiens_hsa053230.62829708
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61933259
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61335690
78Dopaminergic synapse_Homo sapiens_hsa047280.60650459
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.59593292
80Retinol metabolism_Homo sapiens_hsa008300.59372038
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58093480
82Chemical carcinogenesis_Homo sapiens_hsa052040.58009993
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57783227
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54409337
85Sphingolipid metabolism_Homo sapiens_hsa006000.54307712
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.53500160
87Glutathione metabolism_Homo sapiens_hsa004800.50705753
88Long-term depression_Homo sapiens_hsa047300.49487758
89Histidine metabolism_Homo sapiens_hsa003400.49052275
90Propanoate metabolism_Homo sapiens_hsa006400.46848811
91Long-term potentiation_Homo sapiens_hsa047200.45675869
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43935397
93Arginine and proline metabolism_Homo sapiens_hsa003300.43005167
94Arachidonic acid metabolism_Homo sapiens_hsa005900.41862584
95Phagosome_Homo sapiens_hsa041450.41491086
96Butanoate metabolism_Homo sapiens_hsa006500.41415587
97Fatty acid degradation_Homo sapiens_hsa000710.41148226
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.40389566
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39381455
100Epstein-Barr virus infection_Homo sapiens_hsa051690.39223273
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38404550
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.38338992
103Fatty acid metabolism_Homo sapiens_hsa012120.37893592
104Calcium signaling pathway_Homo sapiens_hsa040200.37560885
105Fructose and mannose metabolism_Homo sapiens_hsa000510.37126849
106Alcoholism_Homo sapiens_hsa050340.37069441
107Carbon metabolism_Homo sapiens_hsa012000.36436509
108Tyrosine metabolism_Homo sapiens_hsa003500.35435858
109Biosynthesis of amino acids_Homo sapiens_hsa012300.34858169
110Pentose phosphate pathway_Homo sapiens_hsa000300.34602106
111Vitamin digestion and absorption_Homo sapiens_hsa049770.33331777
112Peroxisome_Homo sapiens_hsa041460.31810689
113Salivary secretion_Homo sapiens_hsa049700.31663758
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31270975
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31007190
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29926718
117One carbon pool by folate_Homo sapiens_hsa006700.29064177
118Folate biosynthesis_Homo sapiens_hsa007900.28840248
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27561098
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26635716
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26318983

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