ACTR8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.10807222
2response to pheromone (GO:0019236)4.97962189
3nuclear pore complex assembly (GO:0051292)4.79999216
4protein localization to chromosome, centromeric region (GO:0071459)4.24714469
5polyketide metabolic process (GO:0030638)4.07942972
6doxorubicin metabolic process (GO:0044598)4.07942972
7daunorubicin metabolic process (GO:0044597)4.07942972
8tricarboxylic acid cycle (GO:0006099)3.89305496
9NADH metabolic process (GO:0006734)3.81326903
10establishment of integrated proviral latency (GO:0075713)3.80616494
11protein localization to kinetochore (GO:0034501)3.78429292
12non-recombinational repair (GO:0000726)3.65792605
13double-strand break repair via nonhomologous end joining (GO:0006303)3.65792605
14DNA double-strand break processing (GO:0000729)3.65221429
15attachment of spindle microtubules to kinetochore (GO:0008608)3.60483446
16negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.60431514
17negative regulation of sister chromatid segregation (GO:0033046)3.60431514
18negative regulation of mitotic sister chromatid separation (GO:2000816)3.60431514
19negative regulation of mitotic sister chromatid segregation (GO:0033048)3.60431514
20dicarboxylic acid biosynthetic process (GO:0043650)3.59973681
21mitotic spindle assembly checkpoint (GO:0007094)3.56719013
22viral mRNA export from host cell nucleus (GO:0046784)3.56241263
23negative regulation of chromosome segregation (GO:0051985)3.55944079
24negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.54940829
25pore complex assembly (GO:0046931)3.47764977
26metaphase plate congression (GO:0051310)3.47369891
27establishment of viral latency (GO:0019043)3.44010135
28oxaloacetate metabolic process (GO:0006107)3.41142866
29spindle assembly checkpoint (GO:0071173)3.40682203
30DNA ligation (GO:0006266)3.40077749
31folic acid-containing compound biosynthetic process (GO:0009396)3.38338275
32mitotic sister chromatid cohesion (GO:0007064)3.35907189
33glutamate secretion (GO:0014047)3.30600594
34DNA methylation involved in gamete generation (GO:0043046)3.29278764
35protein deneddylation (GO:0000338)3.29027160
36pyrimidine dimer repair (GO:0006290)3.25631817
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20042551
38regulation of DNA methylation (GO:0044030)3.17165113
39peptidyl-arginine omega-N-methylation (GO:0035247)3.13162900
40protein localization to microtubule (GO:0035372)3.12438594
41de novo posttranslational protein folding (GO:0051084)3.11182107
42succinate metabolic process (GO:0006105)3.11052677
43cullin deneddylation (GO:0010388)3.09629811
44regulation of translational termination (GO:0006449)3.07595735
45paraxial mesoderm development (GO:0048339)3.07483776
46chromatin silencing (GO:0006342)3.07410724
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.04277845
48positive regulation of synapse maturation (GO:0090129)3.04011154
49mitotic spindle checkpoint (GO:0071174)3.02895973
50establishment of chromosome localization (GO:0051303)3.01241233
51protein localization to chromosome (GO:0034502)2.98407478
52negative regulation of fibroblast apoptotic process (GO:2000270)2.98205786
53mitotic cytokinesis (GO:0000281)2.98097250
54de novo protein folding (GO:0006458)2.97414022
55DNA replication-dependent nucleosome assembly (GO:0006335)2.96790332
56DNA replication-dependent nucleosome organization (GO:0034723)2.96790332
57protein localization to microtubule cytoskeleton (GO:0072698)2.96419767
58tRNA aminoacylation for protein translation (GO:0006418)2.94965979
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93764271
60protein K11-linked ubiquitination (GO:0070979)2.91779166
61mitotic metaphase plate congression (GO:0007080)2.90060496
62SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.88024692
63myelin assembly (GO:0032288)2.87352590
64regulation of sister chromatid segregation (GO:0033045)2.86872801
65regulation of mitotic sister chromatid separation (GO:0010965)2.86872801
66regulation of mitotic sister chromatid segregation (GO:0033047)2.86872801
67regulation of cofactor metabolic process (GO:0051193)2.84685300
68regulation of coenzyme metabolic process (GO:0051196)2.84685300
69pre-miRNA processing (GO:0031054)2.84566757
70amino acid activation (GO:0043038)2.83265675
71tRNA aminoacylation (GO:0043039)2.83265675
72tRNA methylation (GO:0030488)2.82991986
73CENP-A containing nucleosome assembly (GO:0034080)2.82496635
74regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82292946
75chromatin remodeling at centromere (GO:0031055)2.81542471
76regulation of sister chromatid cohesion (GO:0007063)2.81337930
77regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.80385277
78DNA topological change (GO:0006265)2.79998845
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79826020
80ribosome assembly (GO:0042255)2.78367678
81regulation of gene expression by genetic imprinting (GO:0006349)2.77541637
82negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.75795222
83acrosome assembly (GO:0001675)2.74188203
84mitotic nuclear envelope disassembly (GO:0007077)2.72010601
85histone arginine methylation (GO:0034969)2.71903147
86mitotic sister chromatid segregation (GO:0000070)2.71513721
87DNA synthesis involved in DNA repair (GO:0000731)2.71057398
88ganglion development (GO:0061548)2.71047416
89spindle checkpoint (GO:0031577)2.70817625
90nucleobase biosynthetic process (GO:0046112)2.70311139
91oxidative phosphorylation (GO:0006119)2.68866805
92regulation of acyl-CoA biosynthetic process (GO:0050812)2.68546039
93Golgi transport vesicle coating (GO:0048200)2.66803732
94COPI coating of Golgi vesicle (GO:0048205)2.66803732
95aminoglycoside antibiotic metabolic process (GO:0030647)2.65494883
96negative regulation of mitosis (GO:0045839)2.65443706
97nuclear envelope organization (GO:0006998)2.65387126
98IMP biosynthetic process (GO:0006188)2.64939436
99gluconeogenesis (GO:0006094)2.64671304
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63963226
101negative regulation of DNA repair (GO:0045738)2.63407453
102peroxisome fission (GO:0016559)2.62942788
103cytoskeleton-dependent cytokinesis (GO:0061640)2.62334547
104regulation of chromosome segregation (GO:0051983)2.61862267
105IMP metabolic process (GO:0046040)2.61303857
106DNA strand renaturation (GO:0000733)2.60237796
107negative regulation of proteasomal protein catabolic process (GO:1901799)2.60052434
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59643109
109negative regulation of ligase activity (GO:0051352)2.59643109
110pteridine-containing compound biosynthetic process (GO:0042559)2.58992924
111formation of translation preinitiation complex (GO:0001731)2.58980913
112glucocorticoid receptor signaling pathway (GO:0042921)2.57077179
113microtubule anchoring (GO:0034453)2.56553942
114genetic imprinting (GO:0071514)2.55014941
115DNA catabolic process, exonucleolytic (GO:0000738)2.54583459
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52012265
117folic acid metabolic process (GO:0046655)2.51773709
118hexose biosynthetic process (GO:0019319)2.51597890
119regulation of NFAT protein import into nucleus (GO:0051532)2.51053923
120membrane disassembly (GO:0030397)2.50723035
121nuclear envelope disassembly (GO:0051081)2.50723035
122DNA integration (GO:0015074)2.50583132
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50462948
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.49864417
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49864417
126COPII vesicle coating (GO:0048208)2.49059458
127DNA strand elongation involved in DNA replication (GO:0006271)2.47772328
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47666437
129spliceosomal tri-snRNP complex assembly (GO:0000244)2.47280694
130DNA unwinding involved in DNA replication (GO:0006268)2.45115399
131positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44972655
132histone H2A acetylation (GO:0043968)2.44947635
133peptidyl-arginine methylation (GO:0018216)2.44806357
134peptidyl-arginine N-methylation (GO:0035246)2.44806357
135natural killer cell mediated cytotoxicity (GO:0042267)2.44247254
136natural killer cell mediated immunity (GO:0002228)2.44247254
137DNA replication initiation (GO:0006270)2.43932463
138binding of sperm to zona pellucida (GO:0007339)2.43869987
139regulation of mitochondrial translation (GO:0070129)2.43722563
140purine nucleobase biosynthetic process (GO:0009113)2.42516085
141NLS-bearing protein import into nucleus (GO:0006607)2.42232687
142negative regulation of gene expression, epigenetic (GO:0045814)2.41345503
143microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.41263379
144negative regulation of nuclear division (GO:0051784)2.40761442
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.40700173
146postreplication repair (GO:0006301)2.40644135
147heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.39878688
148regulation of spindle organization (GO:0090224)2.39738825
149regulation of helicase activity (GO:0051095)2.38149992
150retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37503366
151mitotic chromosome condensation (GO:0007076)2.36985970
152glycolytic process (GO:0006096)2.36880880
153biotin metabolic process (GO:0006768)2.36795664
154mitochondrial DNA replication (GO:0006264)2.35085313
155misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.34557193
156DNA strand elongation (GO:0022616)2.34510894
157glutamine family amino acid catabolic process (GO:0009065)2.33998245
158negative regulation of proteolysis involved in cellular protein catabolic process (GO:1903051)2.33126798
159mitotic G1 DNA damage checkpoint (GO:0031571)2.32855527
160sister chromatid segregation (GO:0000819)2.32174541
161ribonucleoprotein complex disassembly (GO:0032988)2.32023304
162tricarboxylic acid metabolic process (GO:0072350)2.31382204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.18368271
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.61351363
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58999041
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.47786040
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.35991853
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02753536
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99577118
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91867519
9ELK1_19687146_ChIP-ChIP_HELA_Human2.84734488
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.84139844
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83272405
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.76649494
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.68607771
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.60910340
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60832637
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51109075
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43729697
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.42771797
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34380517
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27749265
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.25936618
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20893173
23WT1_19549856_ChIP-ChIP_CCG9911_Human2.16723755
24GABP_19822575_ChIP-Seq_HepG2_Human2.16537951
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.12872386
26CIITA_25753668_ChIP-Seq_RAJI_Human2.12696006
27* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05920004
28XRN2_22483619_ChIP-Seq_HELA_Human2.03189365
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.00565730
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97263335
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93344503
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89421149
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85924540
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.83162275
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80489695
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80260607
37* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80146700
38FOXP3_21729870_ChIP-Seq_TREG_Human1.80046847
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78502779
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76799625
41SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.70886008
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70810352
43* SRF_21415370_ChIP-Seq_HL-1_Mouse1.70071249
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67009079
45DCP1A_22483619_ChIP-Seq_HELA_Human1.66365110
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65687147
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64468120
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58795936
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57874087
50* YY1_21170310_ChIP-Seq_MESCs_Mouse1.57374170
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55651884
52* VDR_23849224_ChIP-Seq_CD4+_Human1.54251135
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53523297
54MYC_22102868_ChIP-Seq_BL_Human1.47470244
55KDM5A_27292631_Chip-Seq_BREAST_Human1.45739661
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44566614
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42825371
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41864039
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41008997
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40395662
61SOX17_20123909_ChIP-Seq_XEN_Mouse1.38952888
62FUS_26573619_Chip-Seq_HEK293_Human1.38695028
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38491131
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37260856
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.35781776
66EZH2_22144423_ChIP-Seq_EOC_Human1.35096951
67* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34568083
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34543403
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34139068
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33236873
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33121405
72TTF2_22483619_ChIP-Seq_HELA_Human1.32455438
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31797713
74AR_21909140_ChIP-Seq_LNCAP_Human1.30582498
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30000785
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.29974932
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29259926
78BRD4_25478319_ChIP-Seq_HGPS_Human1.24033765
79IGF1R_20145208_ChIP-Seq_DFB_Human1.23207161
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.22467968
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.20590789
82* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19710018
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19496372
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18971240
85IRF1_19129219_ChIP-ChIP_H3396_Human1.18523047
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.17936211
87EWS_26573619_Chip-Seq_HEK293_Human1.17673565
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17164314
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16879622
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15459886
91* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13512301
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13302513
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12940613
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10894233
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09709988
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09355773
97MYC_18940864_ChIP-ChIP_HL60_Human1.09048356
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08946197
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07945757
100REST_18959480_ChIP-ChIP_MESCs_Mouse1.07824507
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07002164
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06606751
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06486132
104ZNF274_21170338_ChIP-Seq_K562_Hela1.05880305
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04988694
106* YY1_22570637_ChIP-Seq_MALME-3M_Human1.04820117
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04718846
108GBX2_23144817_ChIP-Seq_PC3_Human1.04636101
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04408675
110* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01954185
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01875638
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01462839
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00358954
114E2F1_21310950_ChIP-Seq_MCF-7_Human0.99866856
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98517005
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97498120
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.96743292
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96678830
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96045499
120RARB_24833708_ChIP-Seq_LIVER_Mouse0.95961867
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95272474
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95038125
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94216327
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93584547
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92969411
126FOXP1_21924763_ChIP-Seq_HESCs_Human0.92116109
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90224993
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90133300
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89565979
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89343394
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89321337
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89290739
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88931865
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88460513
135SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88154690
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86493182
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83722724
138TFEB_21752829_ChIP-Seq_HELA_Human0.80699730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.08834060
2MP0008877_abnormal_DNA_methylation5.08282155
3MP0005670_abnormal_white_adipose3.51898014
4MP0000569_abnormal_digit_pigmentation3.39220357
5MP0004859_abnormal_synaptic_plasticity3.26130660
6MP0003880_abnormal_central_pattern3.04681655
7MP0002837_dystrophic_cardiac_calcinosis2.86313458
8MP0003111_abnormal_nucleus_morphology2.84506157
9MP0003123_paternal_imprinting2.52832768
10MP0006054_spinal_hemorrhage2.52436604
11MP0002736_abnormal_nociception_after2.42722890
12MP0010352_gastrointestinal_tract_polyps2.36990767
13MP0006036_abnormal_mitochondrial_physio2.29015743
14MP0002653_abnormal_ependyma_morphology2.27144274
15MP0000013_abnormal_adipose_tissue2.24570011
16MP0006035_abnormal_mitochondrial_morpho2.19066098
17MP0003646_muscle_fatigue2.18362233
18MP0010094_abnormal_chromosome_stability2.17943178
19MP0008438_abnormal_cutaneous_collagen2.15507393
20MP0002269_muscular_atrophy2.07978798
21MP0002735_abnormal_chemical_nociception2.03219727
22MP0005257_abnormal_intraocular_pressure2.03031228
23MP0003941_abnormal_skin_development1.92363786
24MP0001293_anophthalmia1.90306392
25MP0000747_muscle_weakness1.83872726
26MP0001968_abnormal_touch/_nociception1.79960832
27MP0002102_abnormal_ear_morphology1.79426846
28MP0003806_abnormal_nucleotide_metabolis1.77827190
29MP0001299_abnormal_eye_distance/1.75960061
30MP0002822_catalepsy1.75646710
31MP0000372_irregular_coat_pigmentation1.70888351
32MP0008260_abnormal_autophagy1.68160331
33MP0003385_abnormal_body_wall1.68029374
34MP0005365_abnormal_bile_salt1.66497671
35MP0004233_abnormal_muscle_weight1.66139075
36MP0005248_abnormal_Harderian_gland1.62272108
37MP0003693_abnormal_embryo_hatching1.60544150
38MP0003077_abnormal_cell_cycle1.60455789
39MP0002877_abnormal_melanocyte_morpholog1.60296408
40MP0004084_abnormal_cardiac_muscle1.59630620
41MP0002938_white_spotting1.58978947
42MP0004133_heterotaxia1.52314931
43MP0003635_abnormal_synaptic_transmissio1.50861514
44MP0002233_abnormal_nose_morphology1.49783167
45MP0003122_maternal_imprinting1.48904153
46MP0005085_abnormal_gallbladder_physiolo1.46314753
47MP0000955_abnormal_spinal_cord1.45993820
48MP0002009_preneoplasia1.45718144
49MP0002139_abnormal_hepatobiliary_system1.45111472
50MP0004036_abnormal_muscle_relaxation1.43957523
51MP0004272_abnormal_basement_membrane1.42420272
52MP0003121_genomic_imprinting1.41424572
53MP0004215_abnormal_myocardial_fiber1.41354805
54MP0004957_abnormal_blastocyst_morpholog1.40531523
55MP0000749_muscle_degeneration1.39945804
56MP0003937_abnormal_limbs/digits/tail_de1.39768307
57MP0008058_abnormal_DNA_repair1.37193237
58MP0002092_abnormal_eye_morphology1.36848901
59MP0000751_myopathy1.35516993
60MP0002090_abnormal_vision1.33840954
61MP0002084_abnormal_developmental_patter1.33815065
62MP0002063_abnormal_learning/memory/cond1.32796909
63MP0003718_maternal_effect1.31954362
64MP0002064_seizures1.30560073
65MP0000358_abnormal_cell_content/1.30429639
66MP0008789_abnormal_olfactory_epithelium1.29518965
67MP0003950_abnormal_plasma_membrane1.29217773
68MP0008875_abnormal_xenobiotic_pharmacok1.28313791
69MP0002909_abnormal_adrenal_gland1.27749729
70MP0000647_abnormal_sebaceous_gland1.27662561
71MP0002751_abnormal_autonomic_nervous1.27566594
72MP0004145_abnormal_muscle_electrophysio1.27435988
73MP0004134_abnormal_chest_morphology1.26752665
74MP0000516_abnormal_urinary_system1.26549398
75MP0005367_renal/urinary_system_phenotyp1.26549398
76MP0000015_abnormal_ear_pigmentation1.26297957
77MP0005408_hypopigmentation1.25665572
78MP0000778_abnormal_nervous_system1.23613153
79MP0000350_abnormal_cell_proliferation1.23313323
80MP0009046_muscle_twitch1.22557453
81MP0002572_abnormal_emotion/affect_behav1.21943676
82MP0004197_abnormal_fetal_growth/weight/1.21617674
83MP0004130_abnormal_muscle_cell1.21009024
84MP0006276_abnormal_autonomic_nervous1.19410327
85MP0001915_intracranial_hemorrhage1.18983621
86MP0002085_abnormal_embryonic_tissue1.17578564
87MP0005394_taste/olfaction_phenotype1.17547400
88MP0005499_abnormal_olfactory_system1.17547400
89MP0005623_abnormal_meninges_morphology1.17541370
90MP0002272_abnormal_nervous_system1.17158035
91MP0003890_abnormal_embryonic-extraembry1.15805600
92MP0003221_abnormal_cardiomyocyte_apopto1.14292840
93MP0005360_urolithiasis1.13202431
94MP0002177_abnormal_outer_ear1.11193278
95MP0004811_abnormal_neuron_physiology1.08369966
96MP0004043_abnormal_pH_regulation1.06842437
97MP0001730_embryonic_growth_arrest1.06330432
98MP0005384_cellular_phenotype1.05534818
99MP0001929_abnormal_gametogenesis1.05397723
100MP0004085_abnormal_heartbeat1.05257559
101MP0005171_absent_coat_pigmentation1.04928283
102MP0009745_abnormal_behavioral_response1.04176781
103MP0001529_abnormal_vocalization1.03625516
104MP0005646_abnormal_pituitary_gland1.03328910
105MP0005197_abnormal_uvea_morphology1.02763885
106MP0002095_abnormal_skin_pigmentation1.02223451
107MP0001286_abnormal_eye_development1.01697744
108MP0009384_cardiac_valve_regurgitation1.01679262
109MP0005193_abnormal_anterior_eye1.01265368
110MP0002078_abnormal_glucose_homeostasis1.01242644
111MP0000003_abnormal_adipose_tissue1.00917518
112MP0005621_abnormal_cell_physiology1.00637890
113MP0001324_abnormal_eye_pigmentation0.99329124
114MP0010329_abnormal_lipoprotein_level0.98875435
115MP0002697_abnormal_eye_size0.98780572
116MP0005266_abnormal_metabolism0.98532621
117MP0006072_abnormal_retinal_apoptosis0.97575137
118MP0005187_abnormal_penis_morphology0.97133701
119MP0010030_abnormal_orbit_morphology0.96869073
120MP0003567_abnormal_fetal_cardiomyocyte0.95813571
121MP0003786_premature_aging0.95549422
122MP0000371_diluted_coat_color0.95402769
123MP0002127_abnormal_cardiovascular_syste0.94844547
124MP0000750_abnormal_muscle_regeneration0.93828433
125MP0008007_abnormal_cellular_replicative0.92193005
126MP0003191_abnormal_cellular_cholesterol0.92140615
127MP0008872_abnormal_physiological_respon0.91649291
128MP0000313_abnormal_cell_death0.90734151
129MP0003091_abnormal_cell_migration0.90592836
130MP0002971_abnormal_brown_adipose0.90116012
131MP0003879_abnormal_hair_cell0.89719529
132MP0002080_prenatal_lethality0.89558270
133MP0003698_abnormal_male_reproductive0.89348969
134MP0005391_vision/eye_phenotype0.88861679
135MP0005666_abnormal_adipose_tissue0.88472352
136MP0005319_abnormal_enzyme/_coenzyme0.88136400
137MP0001501_abnormal_sleep_pattern0.88097946
138MP0001697_abnormal_embryo_size0.87713848
139MP0002067_abnormal_sensory_capabilities0.86877474
140MP0002970_abnormal_white_adipose0.86380122
141MP0001764_abnormal_homeostasis0.86372238
142MP0008932_abnormal_embryonic_tissue0.85687437
143MP0005448_abnormal_energy_balance0.85646154
144MP0010307_abnormal_tumor_latency0.85040164
145MP0004087_abnormal_muscle_fiber0.84733933
146MP0005332_abnormal_amino_acid0.84527425
147MP0000733_abnormal_muscle_development0.84180288
148MP0008770_decreased_survivor_rate0.82317506
149MP0002234_abnormal_pharynx_morphology0.81052123
150MP0003119_abnormal_digestive_system0.79857290
151MP0003935_abnormal_craniofacial_develop0.78690147
152MP0003755_abnormal_palate_morphology0.77056535
153MP0000759_abnormal_skeletal_muscle0.77048431
154MP0002086_abnormal_extraembryonic_tissu0.76315317
155MP0001944_abnormal_pancreas_morphology0.75733443
156MP0005375_adipose_tissue_phenotype0.75666614
157MP0001186_pigmentation_phenotype0.75279578
158MP0003861_abnormal_nervous_system0.75246540
159MP0009703_decreased_birth_body0.75232439
160MP0005220_abnormal_exocrine_pancreas0.75208022
161MP0005410_abnormal_fertilization0.74623733
162MP0001440_abnormal_grooming_behavior0.74440544
163MP0005380_embryogenesis_phenotype0.74108208
164MP0001672_abnormal_embryogenesis/_devel0.74108208
165MP0003984_embryonic_growth_retardation0.72731278
166MP0002088_abnormal_embryonic_growth/wei0.72388040
167MP0001145_abnormal_male_reproductive0.72141194
168MP0004924_abnormal_behavior0.71678315
169MP0000428_abnormal_craniofacial_morphol0.69766081

Predicted human phenotypes

RankGene SetZ-score
1Shoulder girdle muscle weakness (HP:0003547)4.66214693
2Calf muscle hypertrophy (HP:0008981)4.55178216
3Cerebellar dysplasia (HP:0007033)4.55153033
4Myoglobinuria (HP:0002913)4.35893838
5Type II lissencephaly (HP:0007260)4.16542836
6Medulloblastoma (HP:0002885)3.92952627
7Cortical dysplasia (HP:0002539)3.92564338
8Muscle hypertrophy of the lower extremities (HP:0008968)3.90351596
9Pelvic girdle muscle weakness (HP:0003749)3.79758311
10Hypoplasia of the pons (HP:0012110)3.60562923
11Entropion (HP:0000621)3.56753806
12Colon cancer (HP:0003003)3.30090867
13Abnormality of the lower motor neuron (HP:0002366)3.28185979
14Abnormality of the hip-girdle musculature (HP:0001445)3.27414875
15Abnormality of the musculature of the pelvis (HP:0001469)3.27414875
16Abnormality of the pons (HP:0007361)3.26604197
17Ragged-red muscle fibers (HP:0003200)3.14840463
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98716107
19Abnormality of alanine metabolism (HP:0010916)2.98716107
20Hyperalaninemia (HP:0003348)2.98716107
21Limb-girdle muscle atrophy (HP:0003797)2.97555887
22Hepatoblastoma (HP:0002884)2.96935773
23Thoracolumbar scoliosis (HP:0002944)2.77241301
24Autoamputation (HP:0001218)2.73784841
25Upper limb muscle weakness (HP:0003484)2.73622967
26Hypoventilation (HP:0002791)2.73510633
27Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.68979245
28Abnormal mitochondria in muscle tissue (HP:0008316)2.65998504
29Hypoplastic pelvis (HP:0008839)2.63491157
30Volvulus (HP:0002580)2.58873071
31Abnormality of glycolysis (HP:0004366)2.57440632
32Increased serum pyruvate (HP:0003542)2.57440632
33Papillary thyroid carcinoma (HP:0002895)2.57384374
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.56685245
35Difficulty climbing stairs (HP:0003551)2.55923295
36Cutaneous melanoma (HP:0012056)2.54807412
37Microvesicular hepatic steatosis (HP:0001414)2.54663234
38Bifid tongue (HP:0010297)2.53877232
39Oligomenorrhea (HP:0000876)2.48016306
40Hepatic necrosis (HP:0002605)2.47030766
41Hepatocellular necrosis (HP:0001404)2.46744717
42Bundle branch block (HP:0011710)2.45407106
43High anterior hairline (HP:0009890)2.44986764
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43809078
45Ketoacidosis (HP:0001993)2.43260332
46Abnormality of the astrocytes (HP:0100707)2.42261375
47Astrocytoma (HP:0009592)2.42261375
48Poikiloderma (HP:0001029)2.38033801
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34491830
50Supernumerary spleens (HP:0009799)2.30580999
51Acute encephalopathy (HP:0006846)2.30457236
52Hyperammonemia (HP:0001987)2.29267927
53Acute necrotizing encephalopathy (HP:0006965)2.26634402
54Visual hallucinations (HP:0002367)2.26170709
55Aplasia/Hypoplasia of the fibula (HP:0006492)2.25881523
56Rhabdomyolysis (HP:0003201)2.24888364
57Fibular aplasia (HP:0002990)2.24708735
58Ketosis (HP:0001946)2.24097734
59Birth length less than 3rd percentile (HP:0003561)2.22939695
60Tetraparesis (HP:0002273)2.21538976
61Type 2 muscle fiber atrophy (HP:0003554)2.18945734
62Poor eye contact (HP:0000817)2.18244095
63Hyperglycinemia (HP:0002154)2.16125676
64Epileptic encephalopathy (HP:0200134)2.14161629
65Dental crowding (HP:0000678)2.13889649
66Hand muscle atrophy (HP:0009130)2.11657147
67Medial flaring of the eyebrow (HP:0010747)2.11470357
68Emotional lability (HP:0000712)2.10806575
69Generalized muscle weakness (HP:0003324)2.10361823
70Deep palmar crease (HP:0006191)2.09362608
71Abnormality of the Achilles tendon (HP:0005109)2.09310884
72Achilles tendon contracture (HP:0001771)2.08803548
73Congenital primary aphakia (HP:0007707)2.08728235
74Delayed gross motor development (HP:0002194)2.07916478
75Hypoglycemic coma (HP:0001325)2.07494658
76Glioma (HP:0009733)2.07424864
77Insidious onset (HP:0003587)2.06264524
78Termporal pattern (HP:0011008)2.06264524
79Abnormal gallbladder physiology (HP:0012438)2.05933398
80Cholecystitis (HP:0001082)2.05933398
81Cerebral edema (HP:0002181)2.04969996
82Multiple enchondromatosis (HP:0005701)2.04874628
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04678514
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04678514
85Abnormal social behavior (HP:0012433)2.04306731
86Impaired social interactions (HP:0000735)2.04306731
87Rhabdomyosarcoma (HP:0002859)2.02812148
88Deep philtrum (HP:0002002)2.02526555
89Lactic acidosis (HP:0003128)2.01790258
90Premature rupture of membranes (HP:0001788)2.00669799
91Nephrogenic diabetes insipidus (HP:0009806)1.99233198
92Abnormal foot bone ossification (HP:0010675)1.99027588
93Exercise-induced myalgia (HP:0003738)1.99006596
94Hypobetalipoproteinemia (HP:0003563)1.98620030
95Neoplasm of the rectum (HP:0100743)1.98119001
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.97047048
97EMG: myopathic abnormalities (HP:0003458)1.95635043
98Exercise-induced muscle cramps (HP:0003710)1.95213289
99Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95133520
100Amyotrophic lateral sclerosis (HP:0007354)1.95036844
101Status epilepticus (HP:0002133)1.94868402
102CNS demyelination (HP:0007305)1.94060661
103Increased CSF lactate (HP:0002490)1.93653760
104Abnormality of serum amino acid levels (HP:0003112)1.93240807
105Fibular hypoplasia (HP:0003038)1.93190456
106Muscular hypotonia of the trunk (HP:0008936)1.93063301
107Nephroblastoma (Wilms tumor) (HP:0002667)1.92432105
108Neoplasm of the adrenal cortex (HP:0100641)1.92388318
109Left ventricular hypertrophy (HP:0001712)1.91154761
110Increased serum lactate (HP:0002151)1.90871505
111Frequent falls (HP:0002359)1.90597810
112Ependymoma (HP:0002888)1.89726667
113Poor coordination (HP:0002370)1.89617291
114Neuroendocrine neoplasm (HP:0100634)1.89455720
115Tubulointerstitial nephritis (HP:0001970)1.89203273
116Death in childhood (HP:0003819)1.87133620
117EEG with generalized epileptiform discharges (HP:0011198)1.86810128
118High pitched voice (HP:0001620)1.86799357
119Epileptiform EEG discharges (HP:0011182)1.86134429
120Cerebral hypomyelination (HP:0006808)1.85964598
121Impaired vibration sensation in the lower limbs (HP:0002166)1.85917570
122Gait imbalance (HP:0002141)1.85135569
12311 pairs of ribs (HP:0000878)1.84212111
124Abnormality of the calf musculature (HP:0001430)1.84012955
125Poor head control (HP:0002421)1.83317954
126Abnormality of fatty-acid metabolism (HP:0004359)1.83117834
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83116010
128Hypoplasia of the brainstem (HP:0002365)1.83116010
129Basal cell carcinoma (HP:0002671)1.81225395
130Increased number of teeth (HP:0011069)1.81092583
131Hypsarrhythmia (HP:0002521)1.80875666
132Broad foot (HP:0001769)1.80663508
133Limb-girdle muscle weakness (HP:0003325)1.80262038
134Palpitations (HP:0001962)1.79951692
135Upper motor neuron abnormality (HP:0002127)1.79455860
136Abnormality of endocrine pancreas physiology (HP:0012093)1.79433079
137Abnormality of the pancreatic islet cells (HP:0006476)1.79433079
138Mitochondrial inheritance (HP:0001427)1.79097455
139Embryonal renal neoplasm (HP:0011794)1.78518799
140Muscle fiber atrophy (HP:0100295)1.78187369
141Pheochromocytoma (HP:0002666)1.77655547
142Slender build (HP:0001533)1.77031474
143Limb hypertonia (HP:0002509)1.76551036
144Pulmonic stenosis (HP:0001642)1.76498371
145Abnormality of placental membranes (HP:0011409)1.76289574
146Amniotic constriction ring (HP:0009775)1.76289574
147Aplasia/hypoplasia of the humerus (HP:0006507)1.75885925
148Rimmed vacuoles (HP:0003805)1.75361832
149Thyroid carcinoma (HP:0002890)1.75325488
150Lethargy (HP:0001254)1.75212330
151Hammertoe (HP:0001765)1.75052715
152Hyperglycinuria (HP:0003108)1.74861263
153Intellectual disability, profound (HP:0002187)1.74475819
154Increased variability in muscle fiber diameter (HP:0003557)1.74327214
155Resting tremor (HP:0002322)1.73956345
156Gout (HP:0001997)1.73272646
157Agnosia (HP:0010524)1.72806397
158Glossoptosis (HP:0000162)1.72289481
159Hyperinsulinemic hypoglycemia (HP:0000825)1.72141392
160Myelomeningocele (HP:0002475)1.72054459
161Abnormality of the phalanges of the hallux (HP:0010057)1.70114194
162Relative macrocephaly (HP:0004482)1.70071228
163Curly hair (HP:0002212)1.68976368
164Abnormality of the epiphyses of the hand (HP:0005924)1.68527772
165Squamous cell carcinoma (HP:0002860)1.66547371
166Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.66463682
167Neoplasm of the adrenal gland (HP:0100631)1.64910200
168Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64869489
169Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63443526
170Renal duplication (HP:0000075)1.61460427
171Abnormality of chromosome stability (HP:0003220)1.60440326
172Orthostatic hypotension (HP:0001278)1.59860286
173Decreased muscle mass (HP:0003199)1.59329957
174Meningocele (HP:0002435)1.58819453
175Abnormality of the anterior horn cell (HP:0006802)1.58061828
176Degeneration of anterior horn cells (HP:0002398)1.58061828
177Cystic hygroma (HP:0000476)1.57922562
178Prominent metopic ridge (HP:0005487)1.57533038
179Progressive muscle weakness (HP:0003323)1.56104842
180Abnormality of the metopic suture (HP:0005556)1.55810345
181Progressive external ophthalmoplegia (HP:0000590)1.55190456
182Abnormalities of placenta or umbilical cord (HP:0001194)1.54878065
183Neoplasm of the small intestine (HP:0100833)1.53954266
184Spastic diplegia (HP:0001264)1.53179917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.77024729
2BUB13.97699057
3PBK3.26704664
4PDK32.89794178
5PDK42.89794178
6NEK12.42193600
7WEE12.37319522
8MAP3K42.33287456
9ICK2.30441818
10TSSK62.18745418
11BCKDK2.17583260
12SCYL22.12726291
13EPHA32.05240382
14TRIM281.98839273
15CAMKK21.97220405
16CSNK1G31.93904037
17MAP3K91.93104240
18BCR1.86066150
19BRD41.85499263
20CSNK1G11.84187403
21BRSK11.84062642
22FLT31.81803041
23CASK1.77490436
24MAP3K131.77445000
25CSNK1A1L1.77384307
26BRAF1.77163226
27PASK1.73411682
28CSNK1G21.73251469
29MKNK11.71572730
30NTRK31.70575221
31CDC71.66974313
32CCNB11.63119409
33ERBB31.58892670
34MAP2K71.51598558
35CAMK1G1.43106979
36BRSK21.42828408
37TTK1.42414201
38DAPK11.41499870
39MAP2K41.40948786
40PNCK1.40887600
41LIMK11.36117914
42PKN21.34031481
43CDK191.32591707
44AKT31.31944831
45PLK11.30864652
46NEK91.26193976
47EIF2AK11.26153322
48ACVR1B1.23805420
49TAF11.23655985
50PLK41.23215030
51EEF2K1.13007071
52KSR11.12187260
53EIF2AK31.10920057
54NME21.10770699
55MKNK21.10360842
56DDR21.09592602
57MINK11.07862704
58NEK21.07810611
59WNK31.05190652
60PDGFRA1.04685885
61PINK11.04309636
62STK31.03825978
63PLK31.01829747
64ATR0.96086580
65CDK60.95608215
66UHMK10.94336817
67CAMKK10.91182908
68NUAK10.88281742
69MAP3K100.87780174
70ARAF0.86132609
71STK380.84632758
72BMPR1B0.84355746
73MET0.83576919
74CHEK10.80529786
75CDK40.80418480
76CDK80.79984824
77GRK60.78920398
78OBSCN0.77734715
79PLK20.76738924
80PDK20.75407152
81TESK10.75107207
82CDK11A0.73714910
83AURKA0.73232684
84CLK10.72499299
85MAP3K50.72359823
86FGR0.71753292
87RPS6KA40.71681458
88ZAK0.70999218
89PTK2B0.70827379
90CAMK1D0.70587732
91MUSK0.70205828
92RPS6KB20.69672205
93EPHA40.68855308
94ATM0.68644017
95ERBB40.68453693
96MAPKAPK30.67948770
97KSR20.67482768
98DYRK30.67471947
99AURKB0.66678936
100MAP3K80.66532965
101PAK20.66307366
102VRK10.66190632
103MARK10.66127483
104SRPK10.63954011
105MAPK110.63735318
106TAOK20.63473743
107CDK30.62994208
108AKT20.62499352
109DYRK1B0.61376045
110MAP2K10.60213853
111CDK90.60160430
112STK40.59101074
113CDK140.58331702
114CDC42BPA0.57922902
115STK38L0.57185256
116MAP3K60.57055549
117ALK0.56906361
118RPS6KA50.54880360
119TAOK30.54424635
120MELK0.54210127
121STK240.54162825
122MAP3K140.53953109
123CDK70.53746537
124MOS0.53023750
125CDK20.52690518
126PRPF4B0.50687754
127RAF10.48342399
128PRKCI0.48279076
129STK100.47516600
130CHEK20.47440374
131PAK60.47384415
132TIE10.47332370
133TLK10.46421248
134PAK40.45789387
135MYLK0.43635185
136CDK10.43529022
137CDK50.43330435
138TESK20.42509277
139DAPK20.42208674
140CAMK10.41840899
141TRIB30.39537583
142RPS6KB10.37107183
143PAK10.37004108
144MAP2K60.35852809
145CDK180.35049740
146CDK150.32840051
147MAP3K70.32388627
148MAP3K120.31392053
149PDK10.31135615
150PRKCG0.30999755
151YES10.30483906
152PRKDC0.29857765

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.97352721
2Non-homologous end-joining_Homo sapiens_hsa034502.95375772
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84512638
4Cysteine and methionine metabolism_Homo sapiens_hsa002702.62729650
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61779945
6Steroid biosynthesis_Homo sapiens_hsa001002.56912722
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54490783
8Mismatch repair_Homo sapiens_hsa034302.54095873
9Pyruvate metabolism_Homo sapiens_hsa006202.33258325
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25136985
11DNA replication_Homo sapiens_hsa030302.22028008
12Arginine biosynthesis_Homo sapiens_hsa002202.21760505
13Homologous recombination_Homo sapiens_hsa034402.14564663
14Biosynthesis of amino acids_Homo sapiens_hsa012302.10725893
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.07592612
16Carbon metabolism_Homo sapiens_hsa012002.04203554
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97035902
18Synaptic vesicle cycle_Homo sapiens_hsa047211.87174164
19Propanoate metabolism_Homo sapiens_hsa006401.85045598
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.81567300
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76687861
22Protein export_Homo sapiens_hsa030601.74387458
23Oocyte meiosis_Homo sapiens_hsa041141.70474010
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69861943
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67321564
26RNA transport_Homo sapiens_hsa030131.66493432
27Systemic lupus erythematosus_Homo sapiens_hsa053221.58540604
28Cell cycle_Homo sapiens_hsa041101.51948572
29Fatty acid degradation_Homo sapiens_hsa000711.48743179
30Base excision repair_Homo sapiens_hsa034101.41352985
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40418239
32p53 signaling pathway_Homo sapiens_hsa041151.40262400
33RNA polymerase_Homo sapiens_hsa030201.40019307
34Amphetamine addiction_Homo sapiens_hsa050311.35127112
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.33857298
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33200952
37Fatty acid elongation_Homo sapiens_hsa000621.31596852
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30172033
39Nicotine addiction_Homo sapiens_hsa050331.29167092
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29096241
41Selenocompound metabolism_Homo sapiens_hsa004501.28102802
42Spliceosome_Homo sapiens_hsa030401.27827817
43Vitamin B6 metabolism_Homo sapiens_hsa007501.27765888
44Proteasome_Homo sapiens_hsa030501.23811550
45One carbon pool by folate_Homo sapiens_hsa006701.21584674
46Nucleotide excision repair_Homo sapiens_hsa034201.16951441
47Glucagon signaling pathway_Homo sapiens_hsa049221.16408877
48Pyrimidine metabolism_Homo sapiens_hsa002401.13536833
49Vibrio cholerae infection_Homo sapiens_hsa051101.12205546
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11694120
51Alcoholism_Homo sapiens_hsa050341.08502496
52Parkinsons disease_Homo sapiens_hsa050121.07916417
53Viral myocarditis_Homo sapiens_hsa054161.07151240
54Insulin secretion_Homo sapiens_hsa049111.06238287
55Shigellosis_Homo sapiens_hsa051311.05808763
56Long-term potentiation_Homo sapiens_hsa047201.04368095
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03743121
58Fatty acid metabolism_Homo sapiens_hsa012121.02215002
59Fructose and mannose metabolism_Homo sapiens_hsa000511.01929704
60Cardiac muscle contraction_Homo sapiens_hsa042601.00838945
61TGF-beta signaling pathway_Homo sapiens_hsa043500.99275925
62Butanoate metabolism_Homo sapiens_hsa006500.97695806
63Regulation of autophagy_Homo sapiens_hsa041400.96739530
64RNA degradation_Homo sapiens_hsa030180.95896956
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94620111
66Hippo signaling pathway_Homo sapiens_hsa043900.93565452
67Oxidative phosphorylation_Homo sapiens_hsa001900.92390664
68Pentose phosphate pathway_Homo sapiens_hsa000300.92330882
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91148255
70Huntingtons disease_Homo sapiens_hsa050160.90391758
71Epstein-Barr virus infection_Homo sapiens_hsa051690.90162102
72Cocaine addiction_Homo sapiens_hsa050300.87311934
73mRNA surveillance pathway_Homo sapiens_hsa030150.86609579
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.86532571
75GABAergic synapse_Homo sapiens_hsa047270.85971803
76Tryptophan metabolism_Homo sapiens_hsa003800.85197021
77Small cell lung cancer_Homo sapiens_hsa052220.84934120
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84769713
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84488912
80Dopaminergic synapse_Homo sapiens_hsa047280.84133122
81Sphingolipid metabolism_Homo sapiens_hsa006000.84110934
82Purine metabolism_Homo sapiens_hsa002300.82329577
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.82259561
84MicroRNAs in cancer_Homo sapiens_hsa052060.78930176
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78543778
86Circadian entrainment_Homo sapiens_hsa047130.78118287
87Viral carcinogenesis_Homo sapiens_hsa052030.76939903
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76517011
89Phagosome_Homo sapiens_hsa041450.74333378
90Colorectal cancer_Homo sapiens_hsa052100.74305557
91Glutamatergic synapse_Homo sapiens_hsa047240.72417547
92Other glycan degradation_Homo sapiens_hsa005110.70076042
93Peroxisome_Homo sapiens_hsa041460.69701830
94N-Glycan biosynthesis_Homo sapiens_hsa005100.68958650
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.67913921
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66892009
97Circadian rhythm_Homo sapiens_hsa047100.66597895
98Herpes simplex infection_Homo sapiens_hsa051680.66162865
99Adherens junction_Homo sapiens_hsa045200.66114086
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65367773
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64511678
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64228769
103Apoptosis_Homo sapiens_hsa042100.63742511
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63686939
105Collecting duct acid secretion_Homo sapiens_hsa049660.62936404
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61707678
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61189882
108Lysosome_Homo sapiens_hsa041420.60171142
109Lysine degradation_Homo sapiens_hsa003100.57369131
110Salmonella infection_Homo sapiens_hsa051320.56478460
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56135450
112Basal transcription factors_Homo sapiens_hsa030220.56088144
113Antigen processing and presentation_Homo sapiens_hsa046120.55395813
114mTOR signaling pathway_Homo sapiens_hsa041500.53848798
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.53593671
116Metabolic pathways_Homo sapiens_hsa011000.51646114
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51623789
118Fanconi anemia pathway_Homo sapiens_hsa034600.51317614
119Bladder cancer_Homo sapiens_hsa052190.50751087
120Rheumatoid arthritis_Homo sapiens_hsa053230.50573873
121AMPK signaling pathway_Homo sapiens_hsa041520.49896579
122HTLV-I infection_Homo sapiens_hsa051660.48770982
123Proteoglycans in cancer_Homo sapiens_hsa052050.48140255
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47267539
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46965115
126PPAR signaling pathway_Homo sapiens_hsa033200.46575286
127Insulin signaling pathway_Homo sapiens_hsa049100.45539930
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.45151253
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.44949508
130Basal cell carcinoma_Homo sapiens_hsa052170.43611387
131Endometrial cancer_Homo sapiens_hsa052130.42996278
132Hedgehog signaling pathway_Homo sapiens_hsa043400.42971306
133Alzheimers disease_Homo sapiens_hsa050100.42784892
134Thyroid cancer_Homo sapiens_hsa052160.42602962
135Glycerolipid metabolism_Homo sapiens_hsa005610.42473120
136Type II diabetes mellitus_Homo sapiens_hsa049300.42443458
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41946941
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41866064
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41727496
140Galactose metabolism_Homo sapiens_hsa000520.41697139
141Wnt signaling pathway_Homo sapiens_hsa043100.40884361
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39833551
143Melanoma_Homo sapiens_hsa052180.39544365
144Legionellosis_Homo sapiens_hsa051340.38570255
145Folate biosynthesis_Homo sapiens_hsa007900.37791106
146Arginine and proline metabolism_Homo sapiens_hsa003300.37481332
147Hepatitis B_Homo sapiens_hsa051610.37462052
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37045848
149Prostate cancer_Homo sapiens_hsa052150.36556558
150Morphine addiction_Homo sapiens_hsa050320.36312680
151Olfactory transduction_Homo sapiens_hsa047400.34758238
152Long-term depression_Homo sapiens_hsa047300.34223081
153beta-Alanine metabolism_Homo sapiens_hsa004100.32877022

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