ACTRT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.96275164
2plasma membrane fusion (GO:0045026)9.76796518
3epithelial cilium movement (GO:0003351)9.67587391
4axonemal dynein complex assembly (GO:0070286)9.55531786
5motile cilium assembly (GO:0044458)9.35948964
6reproduction (GO:0000003)9.18763630
7regulation of cilium movement (GO:0003352)8.71956778
8cilium or flagellum-dependent cell motility (GO:0001539)8.21438909
9response to pheromone (GO:0019236)7.84346259
10cilium movement (GO:0003341)7.77365906
11negative regulation of inclusion body assembly (GO:0090084)7.46143061
12sperm capacitation (GO:0048240)7.27437264
13single fertilization (GO:0007338)7.23288736
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.07286971
15organic cation transport (GO:0015695)7.03147122
16synaptonemal complex organization (GO:0070193)7.01959125
17phosphatidylethanolamine biosynthetic process (GO:0006646)6.96103988
18spermatogenesis (GO:0007283)6.93981877
19male gamete generation (GO:0048232)6.91427814
20synaptonemal complex assembly (GO:0007130)6.89920917
21rRNA methylation (GO:0031167)6.77961620
22male meiosis (GO:0007140)6.68437917
23piRNA metabolic process (GO:0034587)6.52028048
24microtubule depolymerization (GO:0007019)6.48057175
25phosphatidylethanolamine metabolic process (GO:0046337)6.40828716
26gamete generation (GO:0007276)6.35113140
27regulation of inclusion body assembly (GO:0090083)6.23742874
28protein targeting to Golgi (GO:0000042)6.22680849
29fertilization (GO:0009566)6.19504741
30establishment of protein localization to Golgi (GO:0072600)5.98113709
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.89488002
32chromosome condensation (GO:0030261)5.84986123
33calcium ion-dependent exocytosis (GO:0017156)5.78083923
34cellular ketone body metabolic process (GO:0046950)5.73910571
35rRNA modification (GO:0000154)5.65108159
36DNA packaging (GO:0006323)5.56881867
37germ cell development (GO:0007281)5.52113013
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.45412380
39spermatid nucleus differentiation (GO:0007289)5.36782370
40regulation of microtubule-based movement (GO:0060632)5.15644252
41glycerol ether metabolic process (GO:0006662)5.08776069
42cell recognition (GO:0008037)5.08222999
43ketone body metabolic process (GO:1902224)5.06553000
44ventricular system development (GO:0021591)5.06277392
45multicellular organismal reproductive process (GO:0048609)4.99788166
46centriole replication (GO:0007099)4.92745510
47microtubule severing (GO:0051013)4.88584190
48sexual reproduction (GO:0019953)4.75157306
49seminiferous tubule development (GO:0072520)4.74190234
50positive regulation of Rab GTPase activity (GO:0032851)4.73642203
51regulation of Rab GTPase activity (GO:0032313)4.73642203
52ether metabolic process (GO:0018904)4.70202597
53male meiosis I (GO:0007141)4.66410106
54chromosome organization involved in meiosis (GO:0070192)4.61847932
55centriole assembly (GO:0098534)4.43866021
56regulation of transcription involved in cell fate commitment (GO:0060850)4.42336268
57single strand break repair (GO:0000012)4.40915635
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39929379
59left/right pattern formation (GO:0060972)4.37453577
60protein localization to Golgi apparatus (GO:0034067)4.36637371
61regulation of centriole replication (GO:0046599)4.26873435
62DNA methylation involved in gamete generation (GO:0043046)4.22076867
63chaperone-mediated protein complex assembly (GO:0051131)4.11116021
64sequestering of actin monomers (GO:0042989)4.06810179
65meiotic nuclear division (GO:0007126)4.06558630
66multicellular organismal development (GO:0007275)4.02079302
67meiosis I (GO:0007127)3.71502919
68response to acidic pH (GO:0010447)3.66659097
69positive regulation of endothelial cell differentiation (GO:0045603)3.64109100
70protein polyglutamylation (GO:0018095)3.61270859
71cellular biogenic amine biosynthetic process (GO:0042401)3.58910396
72genitalia morphogenesis (GO:0035112)3.54799975
73coenzyme catabolic process (GO:0009109)3.49846551
74musculoskeletal movement (GO:0050881)3.49647278
75multicellular organismal movement (GO:0050879)3.49647278
76peptidyl-threonine dephosphorylation (GO:0035970)3.43760468
77regulation of spindle checkpoint (GO:0090231)3.41472395
78cellular response to pH (GO:0071467)3.41172165
79protein K11-linked deubiquitination (GO:0035871)3.39721787
80protein refolding (GO:0042026)3.39682499
81amine biosynthetic process (GO:0009309)3.39080207
82negative regulation of Rho protein signal transduction (GO:0035024)3.37837132
83microtubule polymerization or depolymerization (GO:0031109)3.30158051
84cerebral cortex neuron differentiation (GO:0021895)3.29050380
85RNA localization (GO:0006403)3.26392423
86nucleus organization (GO:0006997)3.24189810
87positive regulation of macrophage activation (GO:0043032)3.24154808
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.23933810
89interferon-gamma secretion (GO:0072643)3.23171299
90membrane protein intracellular domain proteolysis (GO:0031293)3.23004865
91amino-acid betaine transport (GO:0015838)3.22122810
92carnitine transport (GO:0015879)3.22122810
93homeostasis of number of cells within a tissue (GO:0048873)3.21846510
94RNA destabilization (GO:0050779)3.21630373
95meiotic cell cycle (GO:0051321)3.20408775
96glycolytic process (GO:0006096)3.17138629
97regulation of interleukin-13 production (GO:0032656)3.16728620
98polyamine biosynthetic process (GO:0006596)3.14522061
99negative regulation of gene expression, epigenetic (GO:0045814)3.12246965
100protein localization to cilium (GO:0061512)3.06827766
101monoubiquitinated protein deubiquitination (GO:0035520)3.06764211
102carnitine transmembrane transport (GO:1902603)3.03461504
103mitotic sister chromatid cohesion (GO:0007064)3.02696133
104receptor recycling (GO:0001881)3.01597066
105protein depolymerization (GO:0051261)2.99303019
106histone H3-K9 demethylation (GO:0033169)2.92969302
107regulation of T-helper 2 cell differentiation (GO:0045628)2.92697882
108nucleoside diphosphate phosphorylation (GO:0006165)2.91738402
109glomerular visceral epithelial cell development (GO:0072015)2.90405700
110chromatin silencing (GO:0006342)2.89750526
111microtubule nucleation (GO:0007020)2.88862324
112regulation of phosphoprotein phosphatase activity (GO:0043666)2.88843458
113positive regulation of guanylate cyclase activity (GO:0031284)2.87775172
114polyol catabolic process (GO:0046174)2.87504670
115glomerular epithelial cell development (GO:0072310)2.84214534
116cranial nerve morphogenesis (GO:0021602)2.83409626
117mitochondrial fission (GO:0000266)2.80931191
118alditol metabolic process (GO:0019400)2.78070719
119DNA conformation change (GO:0071103)2.73988171
120regulation of cilium assembly (GO:1902017)2.73682889
121polyamine metabolic process (GO:0006595)2.71489402
122regulation of endothelial cell differentiation (GO:0045601)2.71131847
123cilium organization (GO:0044782)2.70686033
124nucleosome disassembly (GO:0006337)2.70568207
125protein-DNA complex disassembly (GO:0032986)2.70568207
126meiotic cell cycle process (GO:1903046)2.68171456
127microtubule-based movement (GO:0007018)2.62642294
128mitochondrion degradation (GO:0000422)2.62605289
129synapsis (GO:0007129)2.60455200
130GTP biosynthetic process (GO:0006183)2.59464283
131cilium assembly (GO:0042384)2.59339107
132cellular component assembly involved in morphogenesis (GO:0010927)2.58291828
133cilium morphogenesis (GO:0060271)2.55411808
134axoneme assembly (GO:0035082)2.54055135
135peptidyl-glutamic acid modification (GO:0018200)2.54049353
136negative regulation of organelle assembly (GO:1902116)2.47903162
137intraciliary transport (GO:0042073)2.45635247
138lactate metabolic process (GO:0006089)2.43356772
139sperm motility (GO:0030317)14.3438781
140cell wall macromolecule catabolic process (GO:0016998)13.3530357
141cell wall macromolecule metabolic process (GO:0044036)13.3530357
142fusion of sperm to egg plasma membrane (GO:0007342)12.8239846
143acrosome reaction (GO:0007340)12.7209908
144sperm-egg recognition (GO:0035036)11.7057535
145acrosome assembly (GO:0001675)11.3807751
146binding of sperm to zona pellucida (GO:0007339)10.7411906
147cell-cell recognition (GO:0009988)10.4800570
148multicellular organism reproduction (GO:0032504)10.4550829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.24999732
2EZH2_22144423_ChIP-Seq_EOC_Human4.23960543
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.98143957
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.75403647
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.37519036
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.30065183
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08079336
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91832451
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90618175
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.72664221
11VDR_22108803_ChIP-Seq_LS180_Human2.51201505
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.31294944
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.30111473
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.15247914
15DROSHA_22980978_ChIP-Seq_HELA_Human2.09286299
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05118722
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03220779
18ZNF274_21170338_ChIP-Seq_K562_Hela2.00660131
19ERA_21632823_ChIP-Seq_H3396_Human1.85358303
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84581717
21FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82643270
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80062866
23RAC3_21632823_ChIP-Seq_H3396_Human1.79865645
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.79475941
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.78556852
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78296146
27* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76798014
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.72216668
29STAT1_17558387_ChIP-Seq_HELA_Human1.72121769
30SOX2_22085726_ChIP-Seq_NPCs_Mouse1.70911164
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69727190
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67954299
33FUS_26573619_Chip-Seq_HEK293_Human1.67731143
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.67127993
35* CTCF_27219007_Chip-Seq_Bcells_Human1.66797942
36BCL6_27268052_Chip-Seq_Bcells_Human1.66258448
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.65937067
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.62915961
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62879289
40ER_23166858_ChIP-Seq_MCF-7_Human1.59716319
41E2F1_20622854_ChIP-Seq_HELA_Human1.59646530
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58825976
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54019481
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.52173047
45TAF2_19829295_ChIP-Seq_ESCs_Human1.52126209
46FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51715324
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.51381221
48MYC_19829295_ChIP-Seq_ESCs_Human1.51338974
49P68_20966046_ChIP-Seq_HELA_Human1.50889217
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48901631
51* SMC4_20622854_ChIP-Seq_HELA_Human1.48701104
52SMAD4_21741376_ChIP-Seq_EPCs_Human1.47913518
53TP63_22573176_ChIP-Seq_HFKS_Human1.47288165
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44954246
55LXR_22292898_ChIP-Seq_THP-1_Human1.44859035
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43321351
57CBP_20019798_ChIP-Seq_JUKART_Human1.43321351
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43309281
59OCT4_20526341_ChIP-Seq_ESCs_Human1.42892357
60P300_27268052_Chip-Seq_Bcells_Human1.42016987
61P53_21459846_ChIP-Seq_SAOS-2_Human1.40231282
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39844400
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.39824519
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37639733
65LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37016800
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36448869
67P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.35375532
68* KDM2B_26808549_Chip-Seq_REH_Human1.35204803
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34071261
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33555190
71CEBPB_22108803_ChIP-Seq_LS180_Human1.33489444
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.31973887
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31654213
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.31019529
75* AR_25329375_ChIP-Seq_VCAP_Human1.30440005
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.29932777
77* REST_21632747_ChIP-Seq_MESCs_Mouse1.28240700
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.27172497
79GATA3_21867929_ChIP-Seq_TH1_Mouse1.26459296
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26376579
81RAD21_21589869_ChIP-Seq_MESCs_Mouse1.25766546
82P300_19829295_ChIP-Seq_ESCs_Human1.25295991
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.24473080
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24066678
85CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23924805
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.23844735
87* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.23177160
88GF1_26923725_Chip-Seq_HPCs_Mouse1.22567754
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21535865
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21382657
91* HNFA_21074721_ChIP-Seq_CACO-2_Human1.20744290
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.20307977
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.20164742
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19746297
95TP53_18474530_ChIP-ChIP_U2OS_Human1.19061324
96CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18951293
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.18579775
98* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.17467905
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17078361
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17033662
101SPI1_26923725_Chip-Seq_HPCs_Mouse1.16675613
102SMRT_27268052_Chip-Seq_Bcells_Human1.16613810
103* RBPJ_21746931_ChIP-Seq_IB4_Human1.16000140
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.14423868
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14127261
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14007161
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.13414389
108ERG_20517297_ChIP-Seq_VCAP_Human1.12648680
109RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12556938
110MYC_27129775_Chip-Seq_CORNEA_Mouse1.11993071
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11742131
112RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10265955
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10195961
114GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09678842
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09113322
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09025216
117EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08496487
118* ETV1_20927104_ChIP-Seq_GIST48_Human1.07972533
119JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07823511
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07759027
121RARA_24833708_ChIP-Seq_LIVER_Mouse1.07497600
122* TBL1_22424771_ChIP-Seq_293T_Human1.07480536
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.07405459
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06887833
125ESET_19884257_ChIP-Seq_ESCs_Mouse1.06860670
126CTCF_20526341_ChIP-Seq_ESCs_Human1.06087954
127* NFYB_21822215_ChIP-Seq_K562_Human1.05889295
128BP1_19119308_ChIP-ChIP_Hs578T_Human1.05843994
129* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05164815
130SMAD4_21799915_ChIP-Seq_A2780_Human1.04868117
131KLF4_19829295_ChIP-Seq_ESCs_Human1.04370247
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04288100
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04195523
134* OCT1_27270436_Chip-Seq_PROSTATE_Human1.03185433
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02767024
136NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02222785
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02036891
138GATA1_19941826_ChIP-Seq_K562_Human1.01766185
139* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01342951
140RUNX2_22187159_ChIP-Seq_PCA_Human1.00938850
141* PHF8_20622853_ChIP-Seq_HELA_Human1.00872954
142ELF1_20517297_ChIP-Seq_JURKAT_Human1.00580743
143AR_21572438_ChIP-Seq_LNCaP_Human1.00098123
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.99509778
145HOXB7_26014856_ChIP-Seq_BT474_Human0.99370020
146SOX11_22085726_ChIP-Seq_ESNs_Mouse0.99324176
147LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98871883
148SOX2_19829295_ChIP-Seq_ESCs_Human0.98860092
149NANOG_19829295_ChIP-Seq_ESCs_Human0.98860092
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98733771
151BCOR_27268052_Chip-Seq_Bcells_Human0.96224507
152* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95928865
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94547718
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94484858
155FLI1_21867929_ChIP-Seq_CD8_Mouse0.94132754
156KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93564967
157TAF15_26573619_Chip-Seq_HEK293_Human0.92401664
158SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91408948
159* NANOG_18555785_Chip-Seq_ESCs_Mouse0.90337077
160NANOG_20526341_ChIP-Seq_ESCs_Human0.89464233
161OCT4_18555785_Chip-Seq_ESCs_Mouse0.89309490
162* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89107947
163* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89107947
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89035749
165SOX2_21211035_ChIP-Seq_LN229_Human0.88199966
166P53_22387025_ChIP-Seq_ESCs_Mouse0.87729454
167RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87564302
168SOX9_26525672_Chip-Seq_HEART_Mouse0.86689345
169PHF8_20622854_ChIP-Seq_HELA_Human0.86683256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03868879
2MP0001929_abnormal_gametogenesis5.48616183
3MP0008877_abnormal_DNA_methylation3.66726926
4MP0002161_abnormal_fertility/fecundity3.29116095
5MP0001348_abnormal_lacrimal_gland3.29067077
6MP0002210_abnormal_sex_determination3.23737125
7MP0005670_abnormal_white_adipose3.09379167
8MP0001145_abnormal_male_reproductive2.76848181
9MP0003718_maternal_effect2.45375401
10MP0000653_abnormal_sex_gland2.38593308
11MP0000678_abnormal_parathyroid_gland2.37460514
12MP0002132_abnormal_respiratory_system2.25074014
13MP0002138_abnormal_hepatobiliary_system2.06220936
14MP0002653_abnormal_ependyma_morphology2.04648051
15MP0005410_abnormal_fertilization16.8507235
16MP0005083_abnormal_biliary_tract1.84651158
17MP0003646_muscle_fatigue1.72230599
18MP0009053_abnormal_anal_canal1.57952459
19MP0004233_abnormal_muscle_weight1.57637765
20MP0002160_abnormal_reproductive_system1.57400411
21MP0005379_endocrine/exocrine_gland_phen1.54418050
22MP0002249_abnormal_larynx_morphology1.53500143
23MP0005423_abnormal_somatic_nervous1.41509836
24MP0008004_abnormal_stomach_pH1.33284348
25MP0001486_abnormal_startle_reflex1.32296244
26MP0005310_abnormal_salivary_gland1.31856843
27MP0001485_abnormal_pinna_reflex1.30070141
28MP0005623_abnormal_meninges_morphology1.24460740
29MP0001963_abnormal_hearing_physiology1.12621799
30MP0001765_abnormal_ion_homeostasis1.10398380
31MP0002282_abnormal_trachea_morphology1.09757881
32MP0005085_abnormal_gallbladder_physiolo1.09412719
33MP0004859_abnormal_synaptic_plasticity1.08547466
34MP0004510_myositis1.05648843
35MP0002735_abnormal_chemical_nociception1.04008978
36MP0005395_other_phenotype1.03118520
37MP0002822_catalepsy1.02608004
38MP0001984_abnormal_olfaction1.01226673
39MP0009697_abnormal_copulation0.99598800
40MP0003252_abnormal_bile_duct0.97390989
41MP0000026_abnormal_inner_ear0.95680566
42MP0002127_abnormal_cardiovascular_syste0.93510649
43MP0002234_abnormal_pharynx_morphology0.89442384
44MP0005248_abnormal_Harderian_gland0.86721633
45MP0002067_abnormal_sensory_capabilities0.84265966
46MP0005167_abnormal_blood-brain_barrier0.81462916
47MP0005645_abnormal_hypothalamus_physiol0.80620324
48MP0005647_abnormal_sex_gland0.78062306
49MP0003115_abnormal_respiratory_system0.77780740
50MP0000955_abnormal_spinal_cord0.76480505
51MP0005389_reproductive_system_phenotype0.76418011
52MP0002733_abnormal_thermal_nociception0.73370703
53MP0004085_abnormal_heartbeat0.71234821
54MP0004084_abnormal_cardiac_muscle0.70777386
55MP0009046_muscle_twitch0.68701895
56MP0008058_abnormal_DNA_repair0.67905442
57MP0008995_early_reproductive_senescence0.67211598
58MP0002557_abnormal_social/conspecific_i0.65874372
59MP0005084_abnormal_gallbladder_morpholo0.63987836
60MP0000681_abnormal_thyroid_gland0.63720825
61MP0005666_abnormal_adipose_tissue0.63695613
62MP0003011_delayed_dark_adaptation0.62493574
63MP0005636_abnormal_mineral_homeostasis0.61862825
64MP0005377_hearing/vestibular/ear_phenot0.61858597
65MP0003878_abnormal_ear_physiology0.61858597
66MP0001905_abnormal_dopamine_level0.61777504
67MP0005451_abnormal_body_composition0.61458094
68MP0000049_abnormal_middle_ear0.60181215
69MP0002572_abnormal_emotion/affect_behav0.59437747
70MP0003329_amyloid_beta_deposits0.59253616
71MP0004036_abnormal_muscle_relaxation0.54534761
72MP0001970_abnormal_pain_threshold0.54508987
73MP0009745_abnormal_behavioral_response0.53621121
74MP0000230_abnormal_systemic_arterial0.52209664
75MP0001501_abnormal_sleep_pattern0.51512927
76MP0002272_abnormal_nervous_system0.50644530
77MP0010329_abnormal_lipoprotein_level0.50227253
78MP0001324_abnormal_eye_pigmentation0.50185920
79MP0002269_muscular_atrophy0.49244562
80MP0000358_abnormal_cell_content/0.48827426
81MP0001764_abnormal_homeostasis0.48602360
82MP0000470_abnormal_stomach_morphology0.48426037
83MP0005535_abnormal_body_temperature0.48267440
84MP0009764_decreased_sensitivity_to0.48117871
85MP0000249_abnormal_blood_vessel0.47884702
86MP0006036_abnormal_mitochondrial_physio0.47688246
87MP0001440_abnormal_grooming_behavior0.47424968
88MP0002736_abnormal_nociception_after0.46732795
89MP0001666_abnormal_nutrient_absorption0.45776864
90MP0005464_abnormal_platelet_physiology0.45465845
91MP0000534_abnormal_ureter_morphology0.45437193
92MP0003699_abnormal_female_reproductive0.44386709
93MP0001293_anophthalmia0.44201707
94MP0009278_abnormal_bone_marrow0.44095266
95MP0005397_hematopoietic_system_phenotyp0.43111990
96MP0001545_abnormal_hematopoietic_system0.43111990
97MP0008874_decreased_physiological_sensi0.42152547
98MP0004484_altered_response_of0.41672307
99MP0003137_abnormal_impulse_conducting0.41331232
100MP0001879_abnormal_lymphatic_vessel0.41295267
101MP0000467_abnormal_esophagus_morphology0.40250698
102MP0009115_abnormal_fat_cell0.38291247
103MP0000569_abnormal_digit_pigmentation0.38180577
104MP0005595_abnormal_vascular_smooth0.36950788
105MP0002928_abnormal_bile_duct0.36788995
106MP0005253_abnormal_eye_physiology0.35684623
107MP0010094_abnormal_chromosome_stability0.33749991
108MP0003950_abnormal_plasma_membrane0.33643492
109MP0005551_abnormal_eye_electrophysiolog0.33585291
110MP0003942_abnormal_urinary_system0.32759071
111MP0004133_heterotaxia0.32255668
112MP0004811_abnormal_neuron_physiology0.31455047
113MP0000604_amyloidosis0.30373371
114MP0002971_abnormal_brown_adipose0.29887397
115MP0003633_abnormal_nervous_system0.28390815
116MP0005391_vision/eye_phenotype0.27790512
117MP0002139_abnormal_hepatobiliary_system0.27615781
118MP0006035_abnormal_mitochondrial_morpho0.27556146
119MP0003879_abnormal_hair_cell0.26511381
120MP0003111_abnormal_nucleus_morphology0.25647146
121MP0001968_abnormal_touch/_nociception0.25419688
122MP0001730_embryonic_growth_arrest0.24891261
123MP0003948_abnormal_gas_homeostasis0.24435148
124MP0002169_no_abnormal_phenotype0.23863413
125MP0003861_abnormal_nervous_system0.23657813
126MP0002873_normal_phenotype0.23627828
127MP0002295_abnormal_pulmonary_circulatio0.23587573
128MP0001661_extended_life_span0.22251098
129MP0001849_ear_inflammation0.22129942
130MP0003631_nervous_system_phenotype0.22005782
131MP0002152_abnormal_brain_morphology0.21968563
132MP0005375_adipose_tissue_phenotype0.21344950
133MP0004019_abnormal_vitamin_homeostasis0.21160649
134MP0008961_abnormal_basal_metabolism0.20445175
135MP0001119_abnormal_female_reproductive0.20178486
136MP0004270_analgesia0.19747775
137MP0000751_myopathy0.19659687
138MP0004742_abnormal_vestibular_system0.19543888
139MP0003787_abnormal_imprinting0.19230088
140MP0003959_abnormal_lean_body0.18496859
141MP0004145_abnormal_muscle_electrophysio0.16844199
142MP0004043_abnormal_pH_regulation0.16618199
143MP0002102_abnormal_ear_morphology0.16320676
144MP0008875_abnormal_xenobiotic_pharmacok0.15854315
145MP0002909_abnormal_adrenal_gland0.15713347
146MP0002092_abnormal_eye_morphology0.15449110
147MP0008569_lethality_at_weaning0.15209244
148MP0001727_abnormal_embryo_implantation0.15099051
149MP0000001_mammalian_phenotype0.14249605
150MP0002118_abnormal_lipid_homeostasis0.13797728
151MP0002229_neurodegeneration0.13619110
152MP0002693_abnormal_pancreas_physiology0.13589324
153MP0005319_abnormal_enzyme/_coenzyme0.13557828
154MP0005365_abnormal_bile_salt0.13055523
155MP0000313_abnormal_cell_death0.12841843
156MP0002084_abnormal_developmental_patter0.12746581
157MP0002796_impaired_skin_barrier0.12532217
158MP0000462_abnormal_digestive_system0.11468107
159MP0003786_premature_aging0.11211984

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.20003233
2Abnormal respiratory motile cilium morphology (HP:0005938)9.20003233
3Abnormal respiratory motile cilium physiology (HP:0012261)9.19625310
4Severe visual impairment (HP:0001141)8.70386513
5Rhinitis (HP:0012384)7.40649902
6Chronic bronchitis (HP:0004469)7.31673222
7Infertility (HP:0000789)7.17585644
8Abnormal ciliary motility (HP:0012262)7.10872653
9Nasal polyposis (HP:0100582)6.46667820
10Abnormality of the nasal mucosa (HP:0000433)5.32235262
11Attenuation of retinal blood vessels (HP:0007843)5.11351396
12Bony spicule pigmentary retinopathy (HP:0007737)5.09344965
13Male infertility (HP:0003251)5.04982490
14Hyperkalemia (HP:0002153)4.87167482
15Chronic hepatic failure (HP:0100626)4.67003607
16Bronchitis (HP:0012387)4.59791491
17Abnormal rod and cone electroretinograms (HP:0008323)4.43778093
18Bronchiectasis (HP:0002110)4.39294440
19Abnormality of macular pigmentation (HP:0008002)4.29689098
20Nephronophthisis (HP:0000090)4.17994042
21Resting tremor (HP:0002322)4.16662138
22Potter facies (HP:0002009)3.93176080
23Facial shape deformation (HP:0011334)3.93176080
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.86621755
25Cone-rod dystrophy (HP:0000548)3.85913489
26Abnormal spermatogenesis (HP:0008669)3.81680135
27Hypoplastic ischia (HP:0003175)3.39266688
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.33619548
29Enlarged epiphyses (HP:0010580)3.31725372
30Recurrent otitis media (HP:0000403)3.29393142
31Recurrent sinusitis (HP:0011108)3.14796779
32Hypoalphalipoproteinemia (HP:0003233)3.13952480
33Progressive sensorineural hearing impairment (HP:0000408)3.12745915
34Abnormality of the renal medulla (HP:0100957)3.11764401
35Abnormality of the ischium (HP:0003174)3.10257912
36Hypoplasia of the thymus (HP:0000778)3.05691830
37Postural instability (HP:0002172)2.87156722
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.81786948
39Generalized aminoaciduria (HP:0002909)2.81736992
40Impulsivity (HP:0100710)2.78999778
41Recurrent bronchitis (HP:0002837)2.78537004
42Tubulointerstitial nephritis (HP:0001970)2.75021084
43Abnormality of potassium homeostasis (HP:0011042)2.73662852
44Hypophosphatemic rickets (HP:0004912)2.70731722
45Cholecystitis (HP:0001082)2.67804251
46Abnormal gallbladder physiology (HP:0012438)2.67804251
47Renovascular hypertension (HP:0100817)2.67620565
48Tubular atrophy (HP:0000092)2.65673647
49Optic nerve hypoplasia (HP:0000609)2.63589253
50Unilateral renal agenesis (HP:0000122)2.63027399
51Abnormality of the costochondral junction (HP:0000919)2.56358003
52Amelogenesis imperfecta (HP:0000705)2.56100706
53Abnormality of midbrain morphology (HP:0002418)2.55990012
54Molar tooth sign on MRI (HP:0002419)2.55990012
55Menstrual irregularities (HP:0000858)2.54987777
56Portal hypertension (HP:0001409)2.46780386
57Tubulointerstitial abnormality (HP:0001969)2.44975501
58Osteomalacia (HP:0002749)2.43822485
59Insulin-resistant diabetes mellitus (HP:0000831)2.41313299
60Abnormality of the aortic arch (HP:0012303)2.39823321
61Azoospermia (HP:0000027)2.37917216
62Abnormality of dental color (HP:0011073)2.36397974
63Progressive cerebellar ataxia (HP:0002073)2.35502576
64Gonadotropin excess (HP:0000837)2.31780343
65Upper limb muscle weakness (HP:0003484)2.31765710
66Dyschromatopsia (HP:0007641)2.31155213
67Medial flaring of the eyebrow (HP:0010747)2.30232541
68Peripheral hypomyelination (HP:0007182)2.26355225
69Abnormality of the hepatic vasculature (HP:0006707)2.25153257
70Choroideremia (HP:0001139)2.19293069
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18180493
72Tubulointerstitial fibrosis (HP:0005576)2.05723710
73Widely patent fontanelles and sutures (HP:0004492)2.02195510
74Spastic tetraparesis (HP:0001285)2.01986837
75Epiphyseal dysplasia (HP:0002656)2.01276329
76Flattened epiphyses (HP:0003071)2.01074995
77Absent/shortened dynein arms (HP:0200106)13.3412307
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.3412307
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8700594
80Decreased central vision (HP:0007663)1.99708363
81Ventricular tachycardia (HP:0004756)1.98044670
82Abnormality of purine metabolism (HP:0004352)1.95665105
83Anterior segment dysgenesis (HP:0007700)1.94203655
84Type II lissencephaly (HP:0007260)1.92752933
85Abnormality of the parathyroid morphology (HP:0011766)1.86737283
86Congenital malformation of the right heart (HP:0011723)1.86531497
87Double outlet right ventricle (HP:0001719)1.86531497
88Hemorrhage of the eye (HP:0011885)1.85963391
89Increased purine levels (HP:0004368)1.85866781
90Hyperuricemia (HP:0002149)1.85866781
91Progressive hearing impairment (HP:0001730)1.85793254
92Recurrent pneumonia (HP:0006532)1.84250616
93Polydipsia (HP:0001959)1.83656005
94Abnormal drinking behavior (HP:0030082)1.83656005
95Pendular nystagmus (HP:0012043)1.80165568
96Hyperthyroidism (HP:0000836)1.79932469
97Heterotopia (HP:0002282)1.76648663
98Stage 5 chronic kidney disease (HP:0003774)1.75776848
99Tetany (HP:0001281)1.74306146
100Neurofibrillary tangles (HP:0002185)1.74284676
101Postaxial foot polydactyly (HP:0001830)1.73522569
102Abnormality of the epiphysis of the femoral head (HP:0010574)1.72095844
103Myokymia (HP:0002411)1.72058380
104Muscle fiber atrophy (HP:0100295)1.70472411
105Hyponatremia (HP:0002902)1.70288965
106Abnormality of the pubic bones (HP:0003172)1.69388525
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69086757
108Abnormality of renal excretion (HP:0011036)1.67816864
109Photophobia (HP:0000613)1.67739012
110Retinal dysplasia (HP:0007973)1.66319968
111Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66140788
112Bile duct proliferation (HP:0001408)1.64825049
113Abnormal biliary tract physiology (HP:0012439)1.64825049
114Congenital hepatic fibrosis (HP:0002612)1.63278360
115Bell-shaped thorax (HP:0001591)1.60952276
116Asymmetric septal hypertrophy (HP:0001670)1.59645299
117Abnormality of the renal cortex (HP:0011035)1.58643973
118Short ribs (HP:0000773)1.53345200
119Oculomotor apraxia (HP:0000657)1.50364514
120Aplasia/Hypoplasia of the lens (HP:0008063)1.48450533
121Bundle branch block (HP:0011710)1.46342477
122Abnormal urine output (HP:0012590)1.43686610
123Cerebral inclusion bodies (HP:0100314)1.43098362
124Renal dysplasia (HP:0000110)1.42996659
125Exercise-induced myalgia (HP:0003738)1.42285642
126Easy fatigability (HP:0003388)1.41633764
127Abnormality of permanent molar morphology (HP:0011071)1.38982930
128Abnormality of the dental root (HP:0006486)1.38982930
129Taurodontia (HP:0000679)1.38982930
130Postaxial hand polydactyly (HP:0001162)1.37151288
131Abnormality of dentin (HP:0010299)1.36936176
132Myoglobinuria (HP:0002913)1.36252622
133Loss of speech (HP:0002371)1.35138930
134Fatigable weakness (HP:0003473)1.33818531
135Abnormality of the neuromuscular junction (HP:0003398)1.33818531
136Sensory axonal neuropathy (HP:0003390)1.33543212
137Absent epiphyses (HP:0010577)1.32659796
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.32659796
139Hypercholesterolemia (HP:0003124)1.31699033
140Deformed sella turcica (HP:0002681)1.30872322
141Facial cleft (HP:0002006)1.29739008
142Abnormality of the dental pulp (HP:0006479)1.29734201
143Cerebellar dysplasia (HP:0007033)1.29255432
144Hemiparesis (HP:0001269)1.29151307
145Abnormality of the lower motor neuron (HP:0002366)1.28325261
146Abnormality of molar morphology (HP:0011070)1.27537257
147Abnormality of molar (HP:0011077)1.27537257
148Constricted visual fields (HP:0001133)1.27245887
149Fibular hypoplasia (HP:0003038)1.27194583
150Cystic liver disease (HP:0006706)1.26867962
151Chronic sinusitis (HP:0011109)1.23467653
152Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.22068332
153Rhabdomyolysis (HP:0003201)1.21505540
154Short femoral neck (HP:0100864)1.19058229
155Broad distal phalanx of finger (HP:0009836)1.18213816
156Truncal obesity (HP:0001956)1.18064919
157Nephropathy (HP:0000112)1.17957301
158Abnormality of saccadic eye movements (HP:0000570)1.17291835
159Polyuria (HP:0000103)1.17114480
160Generalized muscle weakness (HP:0003324)1.17061399
161Neoplasm of the heart (HP:0100544)1.15607178
162Amyotrophic lateral sclerosis (HP:0007354)1.15497768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.73092276
2PDK47.73092276
3TESK17.11537994
4PRKD35.55765401
5PDK24.99553086
6DDR24.88715490
7ICK4.87399573
8MAP4K23.41238920
9INSRR3.24500735
10PLK23.00091377
11BRD42.70956425
12ARAF2.62607148
13PTK2B2.25283918
14WNK42.03451797
15STK382.01006406
16STK391.94828359
17MST1R1.74612229
18PNCK1.69223813
19DYRK1B1.68504226
20NEK21.60290730
21PIK3CG1.44871927
22PDK11.27461569
23PIM21.16262589
24CDK71.08905953
25LATS21.05309031
26CDK120.97557335
27RPS6KA20.96000253
28DYRK30.91872038
29PDPK10.86628060
30TYRO30.85919783
31MAPK150.84067486
32IRAK10.80410897
33RIPK40.78048424
34MAP3K90.77805866
35KSR20.77667534
36WNK10.74763468
37AKT30.74440541
38EEF2K0.73069997
39MAP2K20.70934957
40PASK0.70384265
41UHMK10.67647311
42TESK20.64286262
43TEC0.63851552
44CCNB10.61808602
45RPS6KC10.61683101
46RPS6KL10.61683101
47CAMK1D0.59344407
48RPS6KA60.58839024
49PINK10.58427835
50TTK0.58353003
51STK30.58159390
52SIK20.56742728
53MAP2K60.55280018
54CHEK20.55279603
55PRKAA20.54572892
56CAMK10.53959129
57IRAK20.51758101
58ROCK10.51597138
59ZAK0.49875549
60MUSK0.48472357
61CAMK1G0.48301324
62MAP3K80.47419941
63LMTK20.46646885
64MAP3K20.45187991
65NTRK20.43538889
66MAP3K110.42424308
67PAK10.41807476
68CDK30.39847348
69NTRK30.38742216
70STK38L0.37597075
71PRKCG0.37276199
72MAPK100.36615725
73MAP3K100.34786658
74MAPK10.34283958
75ADRBK20.33439073
76CHEK10.33221015
77PAK20.32299297
78CAMK40.30855771
79SGK4940.30273767
80SGK2230.30273767
81BMPR1B0.29277923
82MARK20.28522534
83PAK40.28433868
84LATS10.26657913
85MAPKAPK50.26575735
86MTOR0.26347904
87CAMKK10.25755532
88RAF10.25512224
89ATM0.23560693
90TIE10.23096590
91MARK10.21945661
92MET0.21894877
93PRKCZ0.20428707
94PRKAA10.20382629
95PRKCE0.20355030
96AKT10.20091253
97ATR0.18754392
98GRK60.18304562
99MAPK140.17743813
100NEK60.17416372
101GRK50.17332510
102DYRK20.16783265
103FRK0.16625417
104RPS6KB10.16158575
105MAP3K40.15904560
106SGK10.15875278
107MAPK110.15561386
108OXSR10.15204230
109PRKCQ0.14883593
110CDK150.14860297
111GRK70.13302671
112BMX0.13293765
113BRSK20.12772008
114CDK180.12251432
115WEE10.12118340
116TRPM70.11702221
117CDK11A0.10959348
118PRKG20.10400361
119PLK40.10360713
120RPS6KA10.10224788
121BRSK10.07917035
122PLK10.07637690
123CDK140.07624122
124BRAF0.07554757
125CSF1R0.07104667
126GSK3B0.06193022
127CSNK2A10.05838828
128STK100.05585099
129CDK60.04475494
130PIM10.04236666
131CLK10.04114694
132STK110.03860477
133MARK30.03640291
134PRKCD0.03586360
135CAMK2A0.03405863
136PRKACG0.02684973
137TRIB30.02324879
138PKN10.02059043
139CDC70.02004309
140PRKG10.01911292
141MAPK80.01868935
142CDK20.01398799
143PRKCB0.01392169
144CSNK1D0.00965443
145CDK10.00578242
146PRKCA0.00524028
147PAK60.00404531
148PRKACB-0.0407253
149PRKACA-0.0392637
150PDGFRB-0.0375246
151CDK4-0.0279454
152RPS6KA3-0.0256831
153EPHB1-0.0225349
154ZAP70-0.0184466
155EGFR-0.0168492
156MAP3K1-0.0143498
157AURKA-0.0134746
158MAP3K5-0.0134127
159CSNK2A2-0.0031241

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.33060768
2Fatty acid biosynthesis_Homo sapiens_hsa000614.84328617
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.43227980
4Olfactory transduction_Homo sapiens_hsa047403.39670580
5Pyruvate metabolism_Homo sapiens_hsa006203.26266475
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.24098823
7Vitamin B6 metabolism_Homo sapiens_hsa007503.20514871
8Linoleic acid metabolism_Homo sapiens_hsa005913.13656054
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.90347772
10Butanoate metabolism_Homo sapiens_hsa006502.80322538
11Glucagon signaling pathway_Homo sapiens_hsa049222.52426905
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.48936946
13Propanoate metabolism_Homo sapiens_hsa006402.46320912
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.39714822
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05787612
16Basal transcription factors_Homo sapiens_hsa030222.01086551
17Glycerolipid metabolism_Homo sapiens_hsa005611.98830221
18Selenocompound metabolism_Homo sapiens_hsa004501.95639391
19PPAR signaling pathway_Homo sapiens_hsa033201.92086883
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.82707339
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.79986685
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.71035832
23Fructose and mannose metabolism_Homo sapiens_hsa000511.63399268
24Fat digestion and absorption_Homo sapiens_hsa049751.61674236
25Arginine and proline metabolism_Homo sapiens_hsa003301.61525710
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57986136
27Oocyte meiosis_Homo sapiens_hsa041141.55459091
28Amphetamine addiction_Homo sapiens_hsa050311.54998631
29Mineral absorption_Homo sapiens_hsa049781.53162775
30Fatty acid degradation_Homo sapiens_hsa000711.50464089
31Fatty acid metabolism_Homo sapiens_hsa012121.49843447
32Ether lipid metabolism_Homo sapiens_hsa005651.47473784
33Pentose phosphate pathway_Homo sapiens_hsa000301.40320423
34Type I diabetes mellitus_Homo sapiens_hsa049401.40130562
35Allograft rejection_Homo sapiens_hsa053301.40012768
36Autoimmune thyroid disease_Homo sapiens_hsa053201.36620408
37Cardiac muscle contraction_Homo sapiens_hsa042601.36091469
38Dorso-ventral axis formation_Homo sapiens_hsa043201.35298518
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.33993673
40Carbon metabolism_Homo sapiens_hsa012001.33139408
41Graft-versus-host disease_Homo sapiens_hsa053321.27071355
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22870105
43Phototransduction_Homo sapiens_hsa047441.20551786
44Phenylalanine metabolism_Homo sapiens_hsa003601.18624628
45Arginine biosynthesis_Homo sapiens_hsa002201.17041897
46Glutathione metabolism_Homo sapiens_hsa004801.10611789
47Morphine addiction_Homo sapiens_hsa050321.09638286
48Renin secretion_Homo sapiens_hsa049241.06332615
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.06112134
50Antigen processing and presentation_Homo sapiens_hsa046121.05770755
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01840374
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99621101
53Fanconi anemia pathway_Homo sapiens_hsa034600.98908892
54Hedgehog signaling pathway_Homo sapiens_hsa043400.98666727
55Collecting duct acid secretion_Homo sapiens_hsa049660.95884806
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95607800
57Purine metabolism_Homo sapiens_hsa002300.92534015
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91565993
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.90844761
60Nicotine addiction_Homo sapiens_hsa050330.88151253
61mRNA surveillance pathway_Homo sapiens_hsa030150.87269440
62Insulin secretion_Homo sapiens_hsa049110.87012643
63Arachidonic acid metabolism_Homo sapiens_hsa005900.86543195
64Viral myocarditis_Homo sapiens_hsa054160.85072432
65Huntingtons disease_Homo sapiens_hsa050160.84831716
66Nitrogen metabolism_Homo sapiens_hsa009100.84743340
67Chemical carcinogenesis_Homo sapiens_hsa052040.81001567
68Bile secretion_Homo sapiens_hsa049760.79784705
69Systemic lupus erythematosus_Homo sapiens_hsa053220.79155866
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.78230972
71Thyroid hormone synthesis_Homo sapiens_hsa049180.78144836
72Biosynthesis of amino acids_Homo sapiens_hsa012300.76973359
73Long-term potentiation_Homo sapiens_hsa047200.75840324
74Estrogen signaling pathway_Homo sapiens_hsa049150.75444463
75beta-Alanine metabolism_Homo sapiens_hsa004100.70879833
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70433303
77Serotonergic synapse_Homo sapiens_hsa047260.68708131
78RNA transport_Homo sapiens_hsa030130.67724795
79Retinol metabolism_Homo sapiens_hsa008300.64560158
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64328018
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.62733171
82Tyrosine metabolism_Homo sapiens_hsa003500.61932644
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60878775
84Legionellosis_Homo sapiens_hsa051340.60473050
85Pancreatic secretion_Homo sapiens_hsa049720.58363381
86Renin-angiotensin system_Homo sapiens_hsa046140.58154945
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57007741
88Influenza A_Homo sapiens_hsa051640.55487475
89Salivary secretion_Homo sapiens_hsa049700.55424884
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54292072
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53908133
92Platelet activation_Homo sapiens_hsa046110.53715330
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52387253
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52214455
95Long-term depression_Homo sapiens_hsa047300.52017854
96Acute myeloid leukemia_Homo sapiens_hsa052210.51117053
97Glutamatergic synapse_Homo sapiens_hsa047240.50453616
98Protein digestion and absorption_Homo sapiens_hsa049740.49859466
99Synaptic vesicle cycle_Homo sapiens_hsa047210.49612386
100Calcium signaling pathway_Homo sapiens_hsa040200.49594286
101ABC transporters_Homo sapiens_hsa020100.49140522
102AMPK signaling pathway_Homo sapiens_hsa041520.48351160
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.48107307
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.47817521
105Endocytosis_Homo sapiens_hsa041440.47592432
106Alcoholism_Homo sapiens_hsa050340.45788419
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45655015
108MAPK signaling pathway_Homo sapiens_hsa040100.45172631
109Gastric acid secretion_Homo sapiens_hsa049710.45030194
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43145873
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42384568
112ECM-receptor interaction_Homo sapiens_hsa045120.42242186
113Inositol phosphate metabolism_Homo sapiens_hsa005620.39844268
114Oxytocin signaling pathway_Homo sapiens_hsa049210.39691639
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39294700
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38990833
117Sulfur metabolism_Homo sapiens_hsa009200.38643516
118Tight junction_Homo sapiens_hsa045300.36635276
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36412646
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35827341
121VEGF signaling pathway_Homo sapiens_hsa043700.35769039
122GABAergic synapse_Homo sapiens_hsa047270.35614312
123Metabolic pathways_Homo sapiens_hsa011000.35131443
124Caffeine metabolism_Homo sapiens_hsa002320.33092668
125cAMP signaling pathway_Homo sapiens_hsa040240.32892950
126Cholinergic synapse_Homo sapiens_hsa047250.30932707
127Taste transduction_Homo sapiens_hsa047420.30006726
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29420412
129Circadian entrainment_Homo sapiens_hsa047130.29182012
130Gap junction_Homo sapiens_hsa045400.28719166
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.28689290
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28000859
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27571974
134Cocaine addiction_Homo sapiens_hsa050300.27227463
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24878842
136Viral carcinogenesis_Homo sapiens_hsa052030.23758643
137Pyrimidine metabolism_Homo sapiens_hsa002400.21334142
138Choline metabolism in cancer_Homo sapiens_hsa052310.20673768
139Chemokine signaling pathway_Homo sapiens_hsa040620.18052779
140HIF-1 signaling pathway_Homo sapiens_hsa040660.13579506
141Basal cell carcinoma_Homo sapiens_hsa052170.11861184
142Salmonella infection_Homo sapiens_hsa051320.11855128
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10696010
144B cell receptor signaling pathway_Homo sapiens_hsa046620.10395259
145Insulin resistance_Homo sapiens_hsa049310.08819162
146Wnt signaling pathway_Homo sapiens_hsa043100.08581108
147Type II diabetes mellitus_Homo sapiens_hsa049300.07952825

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