ACVR1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of type B pancreatic cell apoptotic process (GO:2000674)6.08946722
2positive regulation of glycolytic process (GO:0045821)5.78395057
3low-density lipoprotein particle clearance (GO:0034383)5.56573430
4regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.30499488
5regulation of sequestering of triglyceride (GO:0010889)5.15527849
6triglyceride catabolic process (GO:0019433)5.02172433
7glandular epithelial cell differentiation (GO:0002067)4.98107187
8detection of calcium ion (GO:0005513)4.97095546
9type B pancreatic cell development (GO:0003323)4.93728185
10endocrine pancreas development (GO:0031018)4.73219154
11neutral lipid catabolic process (GO:0046461)4.71988431
12acylglycerol catabolic process (GO:0046464)4.71988431
13negative regulation of gluconeogenesis (GO:0045721)4.66634137
14brown fat cell differentiation (GO:0050873)4.63534745
15white fat cell differentiation (GO:0050872)4.58221556
16biotin metabolic process (GO:0006768)4.42975326
17negative regulation of amino acid transport (GO:0051956)4.33446642
18insulin secretion (GO:0030073)4.32036080
19nitric oxide mediated signal transduction (GO:0007263)4.17429300
20regulation of cAMP-dependent protein kinase activity (GO:2000479)4.14658628
21positive regulation of insulin secretion (GO:0032024)3.99587755
22peptide hormone processing (GO:0016486)3.93277299
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86840298
24fatty acid transmembrane transport (GO:1902001)3.81593839
25cellular response to leptin stimulus (GO:0044320)3.79779128
26regulation of protein kinase A signaling (GO:0010738)3.78932692
27glycerolipid catabolic process (GO:0046503)3.78526515
28positive regulation of fatty acid oxidation (GO:0046321)3.75979567
29epithelial cell fate commitment (GO:0072148)3.73883028
30proline transport (GO:0015824)3.73438911
31triglyceride biosynthetic process (GO:0019432)3.71656152
32positive regulation of glycogen biosynthetic process (GO:0045725)3.65589551
33valine metabolic process (GO:0006573)3.64213328
34negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.64085843
35positive regulation of fatty acid beta-oxidation (GO:0032000)3.62753362
36carnitine shuttle (GO:0006853)3.58715604
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56955161
38neutral lipid biosynthetic process (GO:0046460)3.56794711
39acylglycerol biosynthetic process (GO:0046463)3.56794711
40negative regulation of execution phase of apoptosis (GO:1900118)3.52748824
41cellular ketone body metabolic process (GO:0046950)3.51716201
42alanine transport (GO:0032328)3.50572509
43response to leptin (GO:0044321)3.44749486
44glandular epithelial cell development (GO:0002068)3.42707565
45glycine transport (GO:0015816)3.39918455
46lipid particle organization (GO:0034389)3.38969225
47positive regulation of peptide hormone secretion (GO:0090277)3.38826623
48vocalization behavior (GO:0071625)3.35787764
49transcytosis (GO:0045056)3.34494726
50positive regulation of peptide secretion (GO:0002793)3.31470961
51locomotory exploration behavior (GO:0035641)3.31394819
52striatum development (GO:0021756)3.31113677
53activation of protein kinase A activity (GO:0034199)3.30650508
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25821954
55neurotransmitter-gated ion channel clustering (GO:0072578)3.24342289
56positive regulation of glucose import (GO:0046326)3.23421500
57L-alpha-amino acid transmembrane transport (GO:1902475)3.22448819
58cellular response to epinephrine stimulus (GO:0071872)3.21180071
59regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21089667
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20470424
61regulation of glutamate receptor signaling pathway (GO:1900449)3.18938500
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14577173
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14432712
64* regulation of insulin secretion (GO:0050796)3.11595499
65long term synaptic depression (GO:0060292)3.11500299
66positive regulation of glycogen metabolic process (GO:0070875)3.09620938
67ketone body metabolic process (GO:1902224)3.05893999
68fatty acid homeostasis (GO:0055089)3.04238394
69norepinephrine metabolic process (GO:0042415)3.03301693
70regulation of glycogen (starch) synthase activity (GO:2000465)2.98337934
71positive regulation of cellular response to insulin stimulus (GO:1900078)2.97620909
72ionotropic glutamate receptor signaling pathway (GO:0035235)2.97133396
73regulation of energy homeostasis (GO:2000505)2.96698591
74* response to dietary excess (GO:0002021)2.96077765
75peptide hormone secretion (GO:0030072)2.95869504
76fatty acid beta-oxidation (GO:0006635)2.95445654
77positive regulation of neurotransmitter transport (GO:0051590)2.95365411
78adult feeding behavior (GO:0008343)2.95137506
79regulation of cholesterol storage (GO:0010885)2.94787840
80regulation of gluconeogenesis (GO:0006111)2.94751728
81cAMP catabolic process (GO:0006198)2.94398498
82presynaptic membrane assembly (GO:0097105)2.92417468
83neuron-neuron synaptic transmission (GO:0007270)2.91813078
84succinate metabolic process (GO:0006105)2.90566803
85regulation of glucokinase activity (GO:0033131)2.90429569
86regulation of hexokinase activity (GO:1903299)2.90429569
87regulation of fatty acid oxidation (GO:0046320)2.89971105
88coenzyme A biosynthetic process (GO:0015937)2.89285454
89long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.89222832
90synaptic vesicle docking involved in exocytosis (GO:0016081)2.87827891
91adrenergic receptor signaling pathway (GO:0071875)2.87757526
92peptide secretion (GO:0002790)2.87271274
93regulation of synapse structural plasticity (GO:0051823)2.87183387
94retinol metabolic process (GO:0042572)2.86385967
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85487863
96neuronal action potential propagation (GO:0019227)2.83943889
97response to epinephrine (GO:0071871)2.83910517
98diacylglycerol metabolic process (GO:0046339)2.83332929
99negative regulation of amine transport (GO:0051953)2.81615881
100positive regulation of vesicle fusion (GO:0031340)2.80707696
101positive regulation of glucose transport (GO:0010828)2.80606596
102* regulation of peptide hormone secretion (GO:0090276)2.80560943
103fatty-acyl-CoA metabolic process (GO:0035337)2.79819740
104regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79489284
105prepulse inhibition (GO:0060134)2.79407459
106astrocyte differentiation (GO:0048708)2.79183062
107regulation of glycolytic process (GO:0006110)2.78959162
108chemosensory behavior (GO:0007635)2.78506199
109regulation of long-term neuronal synaptic plasticity (GO:0048169)2.77418547
110glycerol metabolic process (GO:0006071)2.76514515
111* regulation of peptide secretion (GO:0002791)2.75562966
112carnitine transmembrane transport (GO:1902603)2.74992535
113positive regulation of glomerulus development (GO:0090193)2.73858583
114regulation of synaptic vesicle exocytosis (GO:2000300)2.73594958
115synaptic vesicle exocytosis (GO:0016079)2.73448353
116positive regulation of insulin receptor signaling pathway (GO:0046628)2.72767923
117regulation of fatty acid beta-oxidation (GO:0031998)2.72579237
118positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.72400493
119glutamate receptor signaling pathway (GO:0007215)2.72293919
120inositol phosphate catabolic process (GO:0071545)2.72257348
121* response to glucose (GO:0009749)2.72251628
122ethanol oxidation (GO:0006069)2.71471536
123protein localization to synapse (GO:0035418)2.70440971
124long-term synaptic potentiation (GO:0060291)2.70298743
125fatty-acyl-CoA biosynthetic process (GO:0046949)2.70231173
126glutamate secretion (GO:0014047)2.69951894
127adaptation of signaling pathway (GO:0023058)2.69888836
128membrane hyperpolarization (GO:0060081)2.69620937
129CDP-diacylglycerol biosynthetic process (GO:0016024)2.69527819
130positive regulation of hormone secretion (GO:0046887)2.68987638
131L-serine transport (GO:0015825)2.68368914
132synaptic transmission, glutamatergic (GO:0035249)2.68216094
133exocrine pancreas development (GO:0031017)2.67160523
134regulation of synaptic transmission, glutamatergic (GO:0051966)2.66521691
135negative regulation of organic acid transport (GO:0032891)2.66503377
136branched-chain amino acid metabolic process (GO:0009081)2.65985869
137triglyceride metabolic process (GO:0006641)2.65971656
138negative regulation of synaptic transmission (GO:0050805)2.65924438
139NADH metabolic process (GO:0006734)2.65863910
140long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.65026624
141negative regulation of lipid catabolic process (GO:0050995)2.64453412
142thioester biosynthetic process (GO:0035384)2.64313988
143acyl-CoA biosynthetic process (GO:0071616)2.64313988
144glycerophospholipid catabolic process (GO:0046475)2.64248219
145synaptic vesicle maturation (GO:0016188)2.63917731
146cellular response to catecholamine stimulus (GO:0071870)2.63471132
147cellular response to monoamine stimulus (GO:0071868)2.63471132
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61422807
149positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61273175
150positive regulation of glucose metabolic process (GO:0010907)2.61243601
151cyclic nucleotide catabolic process (GO:0009214)2.59909778
152* lipid storage (GO:0019915)2.59265513
153synaptic transmission, dopaminergic (GO:0001963)2.58744462
154dendritic spine morphogenesis (GO:0060997)2.58475580
155inositol phosphate dephosphorylation (GO:0046855)2.58279318
156phosphorylated carbohydrate dephosphorylation (GO:0046838)2.58279318
157regulation of lipoprotein metabolic process (GO:0050746)2.56659304
158* response to monosaccharide (GO:0034284)2.54815710
159* response to hexose (GO:0009746)2.54286543
160calcium ion import (GO:0070509)2.53993128
161potassium ion export (GO:0071435)2.53840092
162negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51482469
163* regulation of hormone secretion (GO:0046883)2.51356682
164positive regulation of gluconeogenesis (GO:0045722)2.50291608
165ovulation from ovarian follicle (GO:0001542)2.49796511
166response to catecholamine (GO:0071869)2.47904380
167response to monoamine (GO:0071867)2.47904380
168acylglycerol homeostasis (GO:0055090)2.46181862
169triglyceride homeostasis (GO:0070328)2.46181862
170positive regulation of carbohydrate metabolic process (GO:0045913)2.45776344
171erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.45606257
172L-phenylalanine catabolic process (GO:0006559)2.45606257
173negative regulation of catecholamine secretion (GO:0033604)2.39212263
174auditory receptor cell differentiation (GO:0042491)2.38936403
175early endosome to late endosome transport (GO:0045022)2.36867067
176macroautophagy (GO:0016236)2.36774142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.41047773
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.64565716
3EZH2_22144423_ChIP-Seq_EOC_Human4.33268015
4GBX2_23144817_ChIP-Seq_PC3_Human4.07048691
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74364225
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65674619
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43720800
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43720800
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39581162
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33300601
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29941053
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29193952
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13746945
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08924213
15DROSHA_22980978_ChIP-Seq_HELA_Human2.06437337
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06284716
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02491912
18RARB_27405468_Chip-Seq_BRAIN_Mouse1.93608756
19REST_21632747_ChIP-Seq_MESCs_Mouse1.89079765
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.86338064
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.85799132
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82892226
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.80438043
24TAF15_26573619_Chip-Seq_HEK293_Human1.75105596
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70595551
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.64019416
27SMAD4_21799915_ChIP-Seq_A2780_Human1.62832341
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61476914
29* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61044288
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.60360725
31HTT_18923047_ChIP-ChIP_STHdh_Human1.58344110
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57396666
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56140417
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.56090619
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56006570
36* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54857498
37AR_21572438_ChIP-Seq_LNCaP_Human1.53499031
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52318077
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51020657
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50583993
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47169635
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45260376
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.43756657
44* STAT3_23295773_ChIP-Seq_U87_Human1.43354197
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42169407
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41261308
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39684524
48AR_25329375_ChIP-Seq_VCAP_Human1.39497145
49* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39008530
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38401233
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36430683
52* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.34288231
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32675587
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31783733
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31204981
56* P300_19829295_ChIP-Seq_ESCs_Human1.30055207
57* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29590377
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28476328
59BCAT_22108803_ChIP-Seq_LS180_Human1.27060109
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26947192
61RXR_22108803_ChIP-Seq_LS180_Human1.26582508
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26207951
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25845805
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25262116
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.23814005
66IGF1R_20145208_ChIP-Seq_DFB_Human1.20227292
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19700105
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.19384416
69* TCF4_23295773_ChIP-Seq_U87_Human1.19235880
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19146212
71* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17967259
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.17418713
73AHR_22903824_ChIP-Seq_MCF-7_Human1.15615017
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15159657
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13693744
76* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13644150
77RUNX2_22187159_ChIP-Seq_PCA_Human1.13474145
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13376773
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13187854
80* SOX2_18555785_Chip-Seq_ESCs_Mouse1.11337933
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.11152240
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10364803
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09926646
84* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09900499
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07909826
86CTCF_18555785_Chip-Seq_ESCs_Mouse1.07853765
87ER_23166858_ChIP-Seq_MCF-7_Human1.07288328
88AR_19668381_ChIP-Seq_PC3_Human1.07098854
89* E2F1_18555785_Chip-Seq_ESCs_Mouse1.06800042
90* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06790439
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.06789220
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06731301
93CLOCK_20551151_ChIP-Seq_293T_Human1.06045767
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.05732235
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04355452
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03954971
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03918461
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03779019
99KDM2B_26808549_Chip-Seq_REH_Human1.03576826
100CDX2_22108803_ChIP-Seq_LS180_Human1.02299630
101TP53_18474530_ChIP-ChIP_U2OS_Human1.02102830
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02102310
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.01441749
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.00582618
105* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00198596
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99991404
107* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99880988
108FOXA1_25552417_ChIP-Seq_VCAP_Human0.99819724
109* P300_18555785_Chip-Seq_ESCs_Mouse0.99350520
110FUS_26573619_Chip-Seq_HEK293_Human0.99176922
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.98669589
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97710321
113OCT4_18555785_Chip-Seq_ESCs_Mouse0.97137333
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.96746658
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96674804
116NFE2_27457419_Chip-Seq_LIVER_Mouse0.96194716
117RNF2_27304074_Chip-Seq_NSC_Mouse0.95847132
118NMYC_18555785_Chip-Seq_ESCs_Mouse0.95837042
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94954118
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94954118
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.94185489
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92758600
123* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92378039
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90866920
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90761923
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.89854903
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.89290071
128* P53_22387025_ChIP-Seq_ESCs_Mouse0.88568380
129GATA1_22025678_ChIP-Seq_K562_Human0.88419289
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.87367616
131* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87110610
132* CBP_20019798_ChIP-Seq_JUKART_Human0.87110610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.73527922
2MP0005666_abnormal_adipose_tissue3.98612642
3MP0000013_abnormal_adipose_tissue3.77072476
4MP0004130_abnormal_muscle_cell3.68559405
5MP0002876_abnormal_thyroid_physiology3.57077607
6MP0004859_abnormal_synaptic_plasticity3.49323930
7MP0002822_catalepsy3.34444951
8MP0003122_maternal_imprinting3.24356298
9MP0005375_adipose_tissue_phenotype3.14936773
10MP0002837_dystrophic_cardiac_calcinosis3.12753753
11MP0008004_abnormal_stomach_pH3.02485696
12MP0004185_abnormal_adipocyte_glucose2.98643305
13MP0003880_abnormal_central_pattern2.89025989
14MP0001501_abnormal_sleep_pattern2.50293333
15MP0000003_abnormal_adipose_tissue2.48587015
16MP0002971_abnormal_brown_adipose2.39702037
17MP0003635_abnormal_synaptic_transmissio2.37594463
18MP0002909_abnormal_adrenal_gland2.26528226
19MP0009780_abnormal_chondrocyte_physiolo2.26071942
20MP0010234_abnormal_vibrissa_follicle2.14698149
21MP0009745_abnormal_behavioral_response2.12294014
22MP0005535_abnormal_body_temperature2.11827741
23MP0004270_analgesia2.02958822
24MP0005334_abnormal_fat_pad2.01906088
25MP0003195_calcinosis1.96308615
26MP0009046_muscle_twitch1.93854662
27MP0002063_abnormal_learning/memory/cond1.92858392
28MP0010329_abnormal_lipoprotein_level1.88263464
29MP0003123_paternal_imprinting1.84834651
30MP0009115_abnormal_fat_cell1.84085411
31MP0005645_abnormal_hypothalamus_physiol1.77494435
32MP0001486_abnormal_startle_reflex1.74978809
33MP0003121_genomic_imprinting1.69972903
34MP0002064_seizures1.67357112
35MP0003690_abnormal_glial_cell1.67207068
36MP0002272_abnormal_nervous_system1.61484008
37MP0002572_abnormal_emotion/affect_behav1.60251358
38MP0001661_extended_life_span1.57428603
39MP0001968_abnormal_touch/_nociception1.56226626
40MP0003868_abnormal_feces_composition1.54446781
41MP0002163_abnormal_gland_morphology1.53122901
42MP0003959_abnormal_lean_body1.51510994
43MP0002638_abnormal_pupillary_reflex1.48411286
44MP0005220_abnormal_exocrine_pancreas1.44753629
45MP0002139_abnormal_hepatobiliary_system1.42291236
46MP0005448_abnormal_energy_balance1.41751833
47MP0002734_abnormal_mechanical_nocicepti1.41328731
48MP0005386_behavior/neurological_phenoty1.40268513
49MP0004924_abnormal_behavior1.40268513
50MP0002118_abnormal_lipid_homeostasis1.39875542
51MP0002970_abnormal_white_adipose1.37741793
52MP0008877_abnormal_DNA_methylation1.33412582
53MP0002078_abnormal_glucose_homeostasis1.30930948
54MP0005646_abnormal_pituitary_gland1.28017597
55MP0006072_abnormal_retinal_apoptosis1.24536685
56MP0005332_abnormal_amino_acid1.24507007
57MP0008438_abnormal_cutaneous_collagen1.24428644
58MP0005452_abnormal_adipose_tissue1.24029885
59MP0004019_abnormal_vitamin_homeostasis1.22715576
60MP0005379_endocrine/exocrine_gland_phen1.22581206
61MP0002067_abnormal_sensory_capabilities1.21920028
62MP0008569_lethality_at_weaning1.21544797
63MP0003045_fibrosis1.20086095
64MP0002928_abnormal_bile_duct1.19640493
65MP0002733_abnormal_thermal_nociception1.19312291
66MP0003879_abnormal_hair_cell1.18378981
67MP0003633_abnormal_nervous_system1.16593634
68MP0005365_abnormal_bile_salt1.13723367
69MP0003191_abnormal_cellular_cholesterol1.11937184
70MP0003172_abnormal_lysosome_physiology1.09851986
71MP0001756_abnormal_urination1.09842295
72MP0001177_atelectasis1.06955197
73MP0009643_abnormal_urine_homeostasis1.03753778
74MP0001970_abnormal_pain_threshold1.02924678
75MP0002735_abnormal_chemical_nociception1.01968423
76MP0001440_abnormal_grooming_behavior1.00487189
77MP0004215_abnormal_myocardial_fiber0.99937001
78MP0004484_altered_response_of0.98347146
79MP0005409_darkened_coat_color0.97539562
80MP0003953_abnormal_hormone_level0.95112279
81MP0002069_abnormal_eating/drinking_beha0.94435431
82MP0006276_abnormal_autonomic_nervous0.90873064
83MP0010386_abnormal_urinary_bladder0.90424445
84MP0006036_abnormal_mitochondrial_physio0.90262295
85MP0002736_abnormal_nociception_after0.90158219
86MP0001765_abnormal_ion_homeostasis0.88608054
87MP0000631_abnormal_neuroendocrine_gland0.87972549
88MP0005423_abnormal_somatic_nervous0.85979191
89MP0000639_abnormal_adrenal_gland0.84675673
90MP0002557_abnormal_social/conspecific_i0.83847963
91MP0003646_muscle_fatigue0.83187043
92MP0002066_abnormal_motor_capabilities/c0.81397842
93MP0008961_abnormal_basal_metabolism0.81296889
94MP0008872_abnormal_physiological_respon0.81178286
95MP0004043_abnormal_pH_regulation0.80956748
96MP0008874_decreased_physiological_sensi0.80544469
97MP0001984_abnormal_olfaction0.79934558
98MP0005551_abnormal_eye_electrophysiolog0.78604501
99MP0001188_hyperpigmentation0.78319799
100MP0003787_abnormal_imprinting0.76902041
101MP0000751_myopathy0.76804804
102MP0003011_delayed_dark_adaptation0.76579362
103MP0005620_abnormal_muscle_contractility0.75381567
104MP0005636_abnormal_mineral_homeostasis0.74183147
105MP0004085_abnormal_heartbeat0.72039682
106MP0003186_abnormal_redox_activity0.72030315
107MP0001529_abnormal_vocalization0.71464240
108MP0003075_altered_response_to0.70415198
109MP0003631_nervous_system_phenotype0.69504545
110MP0006138_congestive_heart_failure0.69251600
111MP0004272_abnormal_basement_membrane0.69209336
112MP0001727_abnormal_embryo_implantation0.68600607
113MP0000230_abnormal_systemic_arterial0.68094218
114MP0001986_abnormal_taste_sensitivity0.67435597
115MP0005275_abnormal_skin_tensile0.67402749
116MP0005174_abnormal_tail_pigmentation0.67212001
117MP0001764_abnormal_homeostasis0.66641258
118MP0002254_reproductive_system_inflammat0.66207528
119MP0005266_abnormal_metabolism0.66186046
120MP0002295_abnormal_pulmonary_circulatio0.65910197
121MP0000462_abnormal_digestive_system0.65543742
122MP0005253_abnormal_eye_physiology0.65091160
123MP0003948_abnormal_gas_homeostasis0.64982978
124MP0003283_abnormal_digestive_organ0.63668065
125MP0000470_abnormal_stomach_morphology0.63337922
126MP0000681_abnormal_thyroid_gland0.63040401
127MP0004036_abnormal_muscle_relaxation0.62729992
128MP0001944_abnormal_pancreas_morphology0.62519539
129MP0004811_abnormal_neuron_physiology0.61118970
130MP0001664_abnormal_digestion0.60973973
131MP0002090_abnormal_vision0.60431781
132MP0002693_abnormal_pancreas_physiology0.59777705
133MP0005595_abnormal_vascular_smooth0.59070233
134MP0002184_abnormal_innervation0.58506605
135MP0005167_abnormal_blood-brain_barrier0.58049827
136MP0001502_abnormal_circadian_rhythm0.57864781

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)6.89486834
2Focal motor seizures (HP:0011153)6.31238301
3Acanthosis nigricans (HP:0000956)4.84923497
4Hyperthyroidism (HP:0000836)4.38304463
5Symptomatic seizures (HP:0011145)4.35041989
6Myokymia (HP:0002411)4.12860511
7Insulin-resistant diabetes mellitus (HP:0000831)3.98319588
8Focal seizures (HP:0007359)3.94618647
9Enlarged penis (HP:0000040)3.88756399
10Hypertriglyceridemia (HP:0002155)3.70514402
11Abnormality of the pancreatic islet cells (HP:0006476)3.69397851
12Abnormality of endocrine pancreas physiology (HP:0012093)3.69397851
13Hyperglycinuria (HP:0003108)3.66689086
14Febrile seizures (HP:0002373)3.59250914
15Abnormal eating behavior (HP:0100738)3.52772336
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.51513748
17Epileptic encephalopathy (HP:0200134)3.41960651
18Resting tremor (HP:0002322)3.40644062
19Hyperventilation (HP:0002883)3.34770896
20Thyroid-stimulating hormone excess (HP:0002925)3.34447776
21Abnormal pancreas size (HP:0012094)3.29764482
22Late onset (HP:0003584)3.29364387
23Increased circulating renin level (HP:0000848)3.29339652
24Poor eye contact (HP:0000817)3.21481870
25Large for gestational age (HP:0001520)3.20778155
26Menstrual irregularities (HP:0000858)3.10116929
27Hyperphosphatemia (HP:0002905)3.07024027
28Testicular neoplasm (HP:0010788)3.00384489
29Action tremor (HP:0002345)2.99902993
30Atonic seizures (HP:0010819)2.99515968
31Hypsarrhythmia (HP:0002521)2.95565143
32Agitation (HP:0000713)2.93365329
33Impaired social interactions (HP:0000735)2.92853432
34Abnormal social behavior (HP:0012433)2.92853432
35Ketoacidosis (HP:0001993)2.92090062
36Visual hallucinations (HP:0002367)2.84611946
37Generalized tonic-clonic seizures (HP:0002069)2.83672000
38Growth hormone excess (HP:0000845)2.81393247
39Pheochromocytoma (HP:0002666)2.76410795
40Gaze-evoked nystagmus (HP:0000640)2.75731098
41Myoglobinuria (HP:0002913)2.75343550
42Broad-based gait (HP:0002136)2.74249876
43Hypoglycemic coma (HP:0001325)2.72269230
44Amblyopia (HP:0000646)2.68174302
45Dysmetric saccades (HP:0000641)2.67839201
46Absence seizures (HP:0002121)2.67419098
47Abnormality of serine family amino acid metabolism (HP:0010894)2.65730696
48Abnormality of glycine metabolism (HP:0010895)2.65730696
49Dysdiadochokinesis (HP:0002075)2.64933911
50Neuroendocrine neoplasm (HP:0100634)2.63197185
51Long foot (HP:0001833)2.61200448
52Anxiety (HP:0000739)2.61184848
53Abnormality of calcium-phosphate metabolism (HP:0100530)2.61154698
54Depression (HP:0000716)2.55158554
55Decreased circulating renin level (HP:0003351)2.53146751
56Dialeptic seizures (HP:0011146)2.52528786
57Ventricular fibrillation (HP:0001663)2.52392406
58Double outlet right ventricle (HP:0001719)2.50727020
59Congenital malformation of the right heart (HP:0011723)2.50727020
60Hemiparesis (HP:0001269)2.49155609
61Macroorchidism (HP:0000053)2.41325715
62Abnormality of vitamin B metabolism (HP:0004340)2.41046381
63Exocrine pancreatic insufficiency (HP:0001738)2.38989013
64Truncal ataxia (HP:0002078)2.38469492
65Hyperpituitarism (HP:0010514)2.33575266
66Hypothermia (HP:0002045)2.33225730
67Striae distensae (HP:0001065)2.28806416
68Type I diabetes mellitus (HP:0100651)2.28736933
69Abnormality of vitamin metabolism (HP:0100508)2.28455029
70Insulin resistance (HP:0000855)2.26605353
71Hematochezia (HP:0002573)2.26503960
72Intestinal atresia (HP:0011100)2.23954083
73Nuclear cataract (HP:0100018)2.23494302
74Limb hypertonia (HP:0002509)2.21426116
75Xanthomatosis (HP:0000991)2.20741924
76Pigmentary retinal degeneration (HP:0001146)2.20652124
77Postural tremor (HP:0002174)2.19960452
78Excessive salivation (HP:0003781)2.16270436
79Drooling (HP:0002307)2.16270436
80Hyperlipoproteinemia (HP:0010980)2.15425968
81Bone cyst (HP:0012062)2.14695893
82Testicular atrophy (HP:0000029)2.14627765
83Ketosis (HP:0001946)2.14545492
84Polyphagia (HP:0002591)2.14397652
85Hypercortisolism (HP:0001578)2.14121258
86Large hands (HP:0001176)2.14019227
87Abnormality of renin-angiotensin system (HP:0000847)2.13960122
88Dysmetria (HP:0001310)2.13712442
89Difficulty running (HP:0009046)2.10024637
90Accelerated skeletal maturation (HP:0005616)2.09824336
91Abnormality of alanine metabolism (HP:0010916)2.07381810
92Hyperalaninemia (HP:0003348)2.07381810
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07381810
94Bradycardia (HP:0001662)2.04780692
95Scanning speech (HP:0002168)2.04520590
96Impaired vibration sensation in the lower limbs (HP:0002166)2.04515476
97Blue irides (HP:0000635)2.04319646
98Retinal atrophy (HP:0001105)2.04161288
99Increased CSF protein (HP:0002922)2.03558737
100Intention tremor (HP:0002080)2.01210805
101Hyperglycemia (HP:0003074)2.00014539
102Hypoglycemic seizures (HP:0002173)1.99574639
103Progressive cerebellar ataxia (HP:0002073)1.99444372
104Prominent metopic ridge (HP:0005487)1.97099398
105Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95985584
106Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95668708
107Dicarboxylic aciduria (HP:0003215)1.95668708
108Epileptiform EEG discharges (HP:0011182)1.94311778
109Polygenic inheritance (HP:0010982)1.93663851
110Pancreatic islet-cell hyperplasia (HP:0004510)1.93266575
111Hemiplegia (HP:0002301)1.93186734
112Conjunctival hamartoma (HP:0100780)1.92542379
113Hamartoma of the eye (HP:0010568)1.92181724
114Abnormality of fatty-acid metabolism (HP:0004359)1.91481600
115Exotropia (HP:0000577)1.91239826
116Hyperinsulinemic hypoglycemia (HP:0000825)1.91039419
117Torticollis (HP:0000473)1.90367568
118Prolonged QT interval (HP:0001657)1.89768809
119Subcapsular cataract (HP:0000523)1.87822413
120Increased variability in muscle fiber diameter (HP:0003557)1.87403509
121Increased muscle lipid content (HP:0009058)1.86317601
122Reduced subcutaneous adipose tissue (HP:0003758)1.85459053
123Urinary bladder sphincter dysfunction (HP:0002839)1.83594823
124Adrenal overactivity (HP:0002717)1.83504693
125Abnormality of proline metabolism (HP:0010907)1.83038023
126Hydroxyprolinuria (HP:0003080)1.83038023
127Aplasia involving bones of the extremities (HP:0009825)1.83034245
128Aplasia involving bones of the upper limbs (HP:0009823)1.83034245
129Aplasia of the phalanges of the hand (HP:0009802)1.83034245
130Hyperkalemia (HP:0002153)1.82488493
131Stereotypic behavior (HP:0000733)1.81142924
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80850791
133Tongue fasciculations (HP:0001308)1.80701261
134Bradykinesia (HP:0002067)1.80691003
135EEG with generalized epileptiform discharges (HP:0011198)1.80331330
136Focal dystonia (HP:0004373)1.79925808
137Gait ataxia (HP:0002066)1.79791504
138Hypomagnesemia (HP:0002917)1.79504101
139Muscular hypotonia of the trunk (HP:0008936)1.79479632
140Abnormality of the metopic suture (HP:0005556)1.79110848
141Abnormal EKG (HP:0003115)1.78882308
142Metaphyseal dysplasia (HP:0100255)1.78819948
143Prominent supraorbital ridges (HP:0000336)1.77822595
144Truncal obesity (HP:0001956)1.77576479
145Epidermoid cyst (HP:0200040)1.76918765
146Hyperparathyroidism (HP:0000843)1.76789872
147Renal cortical cysts (HP:0000803)1.76304894
148Impaired vibratory sensation (HP:0002495)1.76150936
149Abnormality of salivation (HP:0100755)1.75569591
150Congenital cataract (HP:0000519)1.74763378
151Downturned corners of mouth (HP:0002714)1.73577853
152Vascular calcification (HP:0004934)1.73245798
153Craniofacial dystonia (HP:0012179)1.71615542
154Syncope (HP:0001279)1.71483971
155Proximal tubulopathy (HP:0000114)1.67162544
1563-Methylglutaconic aciduria (HP:0003535)1.65473082
157Abnormality of urine glucose concentration (HP:0011016)1.58124900
158Glycosuria (HP:0003076)1.58124900
159Steatorrhea (HP:0002570)1.57065526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.96620902
2EPHA44.36927251
3CAMK1D4.08861168
4NTRK33.68845468
5CAMK1G3.27751855
6CASK2.43461461
7DAPK22.43391714
8TNIK2.42270305
9PRKD32.27807516
10INSRR2.24082370
11MAP2K62.07249792
12FRK1.98409946
13CAMKK21.95320768
14SIK11.88505397
15TRIB31.76237901
16NTRK11.76006077
17LMTK21.75949793
18ACVR1B1.73731917
19MAP3K41.73484138
20BCKDK1.72673158
21RIPK41.68997195
22PDK41.65971503
23PDK31.65971503
24PRPF4B1.62350273
25MAP2K71.59160329
26NTRK21.56781508
27NLK1.54320722
28MAP3K91.53977715
29HIPK21.53230667
30MINK11.52803110
31CAMKK11.51604540
32UHMK11.47018338
33TRPM71.45651335
34GRK11.39256320
35MAP4K21.33350338
36YES11.32839708
37KSR11.32686684
38TIE11.32316892
39FGFR21.28774465
40RIPK11.26134436
41MAP3K131.24118195
42KSR21.23672257
43MAP2K41.21744151
44DAPK11.20661067
45PAK61.19562911
46CDK51.17625922
47MAP3K21.17364746
48PRKAA21.16268870
49SIK31.11557638
50CAMK11.11548776
51CAMK2D1.09629364
52PDPK11.09056966
53BMPR21.08982016
54TESK11.03242459
55MAP3K121.02406342
56EPHA31.01908109
57MST1R1.00133427
58PRKCH0.98092340
59PDK10.96772315
60STK30.96394976
61PDK20.95899758
62TNK20.95616187
63PINK10.93789908
64STK38L0.91388773
65SGK10.90442601
66STK110.89749664
67IRAK30.89698132
68SGK20.89475459
69SGK4940.86360226
70SGK2230.86360226
71STK240.85818687
72MAP2K10.85062545
73PRKD20.84897129
74IRAK10.82758054
75PIK3CA0.82201182
76PLK20.81564062
77GRK50.81044266
78MAPK130.79739187
79AKT30.79215677
80MST40.77726711
81FGFR30.77667482
82SGK30.74647615
83SCYL20.74168386
84PHKG10.73250450
85PHKG20.73250450
86SIK20.73032916
87CDK90.71789659
88FES0.71119399
89ARAF0.67789718
90MARK20.67100202
91PTK2B0.67006525
92MAPK110.65489921
93MARK10.64016036
94PRKCG0.63482603
95ADRBK10.62884062
96PRKG10.62601006
97CAMK2A0.62487548
98FER0.61625008
99STK380.60427920
100PRKACG0.60069186
101RET0.58656618
102BCR0.58126546
103PRKCE0.57763313
104PRKAA10.57720504
105STK390.56359413
106MAP3K60.55228515
107RPS6KB10.52989515
108OXSR10.52962172
109CAMK2B0.52122022
110JAK10.50756164
111CDK30.49517464
112PRKACB0.49106518
113IRAK20.48734683
114CCNB10.47287184
115RPS6KA30.46696140
116PAK30.46353283
117PNCK0.46027301
118WNK40.44926921
119WNK30.43220617
120RAF10.42937361
121ABL20.42888172
122BMPR1B0.42349561
123PRKACA0.42210438
124PDGFRA0.41472617
125ADRBK20.39673699
126NEK60.38775197
127GSK3A0.37792837
128MAP3K10.37456492
129PRKCZ0.36994026
130MYLK0.36787274
131MKNK20.34755363
132JAK20.32903919
133PTK20.31778659
134LATS10.31561531
135OBSCN0.30396525
136IGF1R0.29540098
137EIF2AK20.28047637

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.40674474
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.61164824
3Fatty acid biosynthesis_Homo sapiens_hsa000613.37276437
4Propanoate metabolism_Homo sapiens_hsa006402.80996154
5PPAR signaling pathway_Homo sapiens_hsa033202.71871891
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36154389
7Nicotine addiction_Homo sapiens_hsa050332.30529486
8Morphine addiction_Homo sapiens_hsa050322.17740463
9Renin secretion_Homo sapiens_hsa049242.12966537
10Glycerolipid metabolism_Homo sapiens_hsa005612.08186780
11Olfactory transduction_Homo sapiens_hsa047401.99224841
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97190250
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93692065
14Fatty acid metabolism_Homo sapiens_hsa012121.92779020
15Long-term potentiation_Homo sapiens_hsa047201.90708904
16Circadian entrainment_Homo sapiens_hsa047131.90465271
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86803757
18Salivary secretion_Homo sapiens_hsa049701.84307598
19Amphetamine addiction_Homo sapiens_hsa050311.79929579
20GABAergic synapse_Homo sapiens_hsa047271.76227704
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72821107
22Glutamatergic synapse_Homo sapiens_hsa047241.68178463
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60246509
24Synaptic vesicle cycle_Homo sapiens_hsa047211.55213595
25Dopaminergic synapse_Homo sapiens_hsa047281.54207398
26Taste transduction_Homo sapiens_hsa047421.48985981
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.46117100
28Insulin secretion_Homo sapiens_hsa049111.44168020
29Tryptophan metabolism_Homo sapiens_hsa003801.41859066
30Cocaine addiction_Homo sapiens_hsa050301.39345586
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39134479
32Type II diabetes mellitus_Homo sapiens_hsa049301.36994872
33Folate biosynthesis_Homo sapiens_hsa007901.34159539
34Cholinergic synapse_Homo sapiens_hsa047251.33903610
35AMPK signaling pathway_Homo sapiens_hsa041521.32879231
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31743556
37Fatty acid degradation_Homo sapiens_hsa000711.29129225
38cAMP signaling pathway_Homo sapiens_hsa040241.28249803
39Calcium signaling pathway_Homo sapiens_hsa040201.27496449
40Glucagon signaling pathway_Homo sapiens_hsa049221.27318531
41Sulfur metabolism_Homo sapiens_hsa009201.24130054
42Gastric acid secretion_Homo sapiens_hsa049711.21683166
43Pyruvate metabolism_Homo sapiens_hsa006201.20042080
44Oxytocin signaling pathway_Homo sapiens_hsa049211.15364702
45Long-term depression_Homo sapiens_hsa047301.14934259
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11111756
47Insulin signaling pathway_Homo sapiens_hsa049101.09126692
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08968221
49Type I diabetes mellitus_Homo sapiens_hsa049401.02741940
50Serotonergic synapse_Homo sapiens_hsa047261.01712044
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01158665
52Histidine metabolism_Homo sapiens_hsa003401.00412595
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00223792
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98775657
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96904519
56beta-Alanine metabolism_Homo sapiens_hsa004100.92609671
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.90646979
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89301625
59Butanoate metabolism_Homo sapiens_hsa006500.89047251
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88738516
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84495502
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84385854
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84332404
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.82464861
65Fat digestion and absorption_Homo sapiens_hsa049750.79532520
66Estrogen signaling pathway_Homo sapiens_hsa049150.79074959
67Insulin resistance_Homo sapiens_hsa049310.78550576
68Gap junction_Homo sapiens_hsa045400.78119173
69Pancreatic secretion_Homo sapiens_hsa049720.75534379
70GnRH signaling pathway_Homo sapiens_hsa049120.74086610
71Ether lipid metabolism_Homo sapiens_hsa005650.73877503
72Bile secretion_Homo sapiens_hsa049760.71989174
73Protein export_Homo sapiens_hsa030600.70667291
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68733456
75Thyroid hormone synthesis_Homo sapiens_hsa049180.68469963
76Glioma_Homo sapiens_hsa052140.68397924
77Melanogenesis_Homo sapiens_hsa049160.68280504
78Collecting duct acid secretion_Homo sapiens_hsa049660.67307463
79Nitrogen metabolism_Homo sapiens_hsa009100.66251387
80Mineral absorption_Homo sapiens_hsa049780.64686261
81Vitamin B6 metabolism_Homo sapiens_hsa007500.64173516
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60100600
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58366009
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.58326368
85Arginine biosynthesis_Homo sapiens_hsa002200.57364780
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56350826
87Starch and sucrose metabolism_Homo sapiens_hsa005000.52699934
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51815197
89ErbB signaling pathway_Homo sapiens_hsa040120.51786547
90Retinol metabolism_Homo sapiens_hsa008300.51776624
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49681289
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49083703
93Oxidative phosphorylation_Homo sapiens_hsa001900.48619608
94Peroxisome_Homo sapiens_hsa041460.48445461
95Carbon metabolism_Homo sapiens_hsa012000.47478165
96mTOR signaling pathway_Homo sapiens_hsa041500.46874761
97Circadian rhythm_Homo sapiens_hsa047100.46538558
98ABC transporters_Homo sapiens_hsa020100.46162036
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46145964
100Alzheimers disease_Homo sapiens_hsa050100.45784283
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45360108
102Regulation of autophagy_Homo sapiens_hsa041400.44796677
103Sphingolipid metabolism_Homo sapiens_hsa006000.43073094
104Renin-angiotensin system_Homo sapiens_hsa046140.42714694
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42688972
106Dilated cardiomyopathy_Homo sapiens_hsa054140.42221704
107Vibrio cholerae infection_Homo sapiens_hsa051100.41856812
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41609476
109Choline metabolism in cancer_Homo sapiens_hsa052310.40959255
110Phenylalanine metabolism_Homo sapiens_hsa003600.39465164
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.39336924
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.38864094
113Inositol phosphate metabolism_Homo sapiens_hsa005620.38768459
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38189388
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.37858964
116Fatty acid elongation_Homo sapiens_hsa000620.35933719
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35875525
118Dorso-ventral axis formation_Homo sapiens_hsa043200.35222128
119Ras signaling pathway_Homo sapiens_hsa040140.34508345
120Cardiac muscle contraction_Homo sapiens_hsa042600.32393696
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31413607
122Ovarian steroidogenesis_Homo sapiens_hsa049130.29962219
123Rap1 signaling pathway_Homo sapiens_hsa040150.29779642
124Protein digestion and absorption_Homo sapiens_hsa049740.28698652
125Phototransduction_Homo sapiens_hsa047440.28393843
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.28169469
127Axon guidance_Homo sapiens_hsa043600.27819684
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27661136
129Oocyte meiosis_Homo sapiens_hsa041140.26922352
130Tyrosine metabolism_Homo sapiens_hsa003500.25819571

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