ACVR2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.89933560
2layer formation in cerebral cortex (GO:0021819)5.00129982
3nucleobase catabolic process (GO:0046113)4.98917541
4presynaptic membrane assembly (GO:0097105)4.72824044
5limb bud formation (GO:0060174)4.71885133
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.45999509
7axonal fasciculation (GO:0007413)4.41976268
8dendritic spine morphogenesis (GO:0060997)4.32591213
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.18636421
10dendrite morphogenesis (GO:0048813)4.15315245
11neuron recognition (GO:0008038)4.13784974
12presynaptic membrane organization (GO:0097090)4.13598767
13vocalization behavior (GO:0071625)4.12108217
14locomotory exploration behavior (GO:0035641)4.10357444
15central nervous system projection neuron axonogenesis (GO:0021952)4.04659601
16neuron cell-cell adhesion (GO:0007158)4.01832808
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96919681
18synaptic vesicle maturation (GO:0016188)3.88790886
19water-soluble vitamin biosynthetic process (GO:0042364)3.86068437
20regulation of glutamate receptor signaling pathway (GO:1900449)3.85490771
21cell migration in hindbrain (GO:0021535)3.78621573
22behavioral response to nicotine (GO:0035095)3.78016546
23neural tube formation (GO:0001841)3.75925699
24monoubiquitinated protein deubiquitination (GO:0035520)3.75113676
25somite development (GO:0061053)3.72265116
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.66546499
27glutamate secretion (GO:0014047)3.65724518
28retinal ganglion cell axon guidance (GO:0031290)3.64090481
29exploration behavior (GO:0035640)3.59936217
30innervation (GO:0060384)3.57675848
31protein localization to synapse (GO:0035418)3.54677588
32DNA double-strand break processing (GO:0000729)3.52978162
33negative regulation of transcription regulatory region DNA binding (GO:2000678)3.51640120
34response to pheromone (GO:0019236)3.49973957
35axon extension (GO:0048675)3.46551777
36neurotransmitter-gated ion channel clustering (GO:0072578)3.39870048
37synaptic vesicle exocytosis (GO:0016079)3.35596265
38kidney morphogenesis (GO:0060993)3.34392215
39gamma-aminobutyric acid transport (GO:0015812)3.33064582
40sympathetic nervous system development (GO:0048485)3.33048555
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.28873549
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28263972
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.28069844
44auditory behavior (GO:0031223)3.27659793
45regulation of synaptic vesicle exocytosis (GO:2000300)3.22357203
46protein polyglutamylation (GO:0018095)3.21344576
47glutamate receptor signaling pathway (GO:0007215)3.18617568
48regulation of synapse structural plasticity (GO:0051823)3.17875037
49intraciliary transport (GO:0042073)3.17225026
50replication fork processing (GO:0031297)3.14542052
51establishment of nucleus localization (GO:0040023)3.12889278
52central nervous system neuron axonogenesis (GO:0021955)3.09266719
53cochlea development (GO:0090102)3.04007641
54positive regulation of synapse maturation (GO:0090129)3.03613758
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00588886
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99291637
57proline transport (GO:0015824)2.98936613
58regulation of long-term neuronal synaptic plasticity (GO:0048169)2.98893526
59neuron projection extension (GO:1990138)2.97073087
60regulation of neuronal synaptic plasticity (GO:0048168)2.96798788
61regulation of timing of cell differentiation (GO:0048505)2.95694469
62cerebellar Purkinje cell differentiation (GO:0021702)2.94036670
63startle response (GO:0001964)2.92432735
64regulation of axon extension involved in axon guidance (GO:0048841)2.90870272
65synaptic transmission, glutamatergic (GO:0035249)2.90500848
66transmission of nerve impulse (GO:0019226)2.88513260
67resolution of meiotic recombination intermediates (GO:0000712)2.86780788
68neurotransmitter secretion (GO:0007269)2.86606736
69spinal cord development (GO:0021510)2.84797464
70olfactory bulb development (GO:0021772)2.84747275
71regulation of dendritic spine morphogenesis (GO:0061001)2.84258159
72regulation of axon guidance (GO:1902667)2.81969197
73dendritic spine organization (GO:0097061)2.80759609
74synapse assembly (GO:0007416)2.79948768
75response to auditory stimulus (GO:0010996)2.79618050
76activation of protein kinase A activity (GO:0034199)2.79556986
77histone H2A acetylation (GO:0043968)2.79394828
78epithelial cilium movement (GO:0003351)2.78764549
79regulation of synaptic vesicle transport (GO:1902803)2.78571344
80regulation of development, heterochronic (GO:0040034)2.76391362
81platelet dense granule organization (GO:0060155)2.75716760
82regulation of telomere maintenance (GO:0032204)2.75408694
83nonmotile primary cilium assembly (GO:0035058)2.75074262
84postsynaptic membrane organization (GO:0001941)2.74006960
85synapse organization (GO:0050808)2.73911517
86regulation of collateral sprouting (GO:0048670)2.73831346
87indolalkylamine metabolic process (GO:0006586)2.73500683
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71904859
89serotonin metabolic process (GO:0042428)2.71404939
90regulation of cAMP-dependent protein kinase activity (GO:2000479)2.71381526
91neuron-neuron synaptic transmission (GO:0007270)2.71271764
92regulation of action potential (GO:0098900)2.70427475
93positive regulation of oligodendrocyte differentiation (GO:0048714)2.66162751
94positive regulation of action potential (GO:0045760)2.65903162
95positive regulation of mitochondrial fission (GO:0090141)2.65459911
96embryonic epithelial tube formation (GO:0001838)2.65406627
97positive regulation of axon extension (GO:0045773)2.64590550
98homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.64387059
99cell communication by electrical coupling (GO:0010644)2.63680314
100positive regulation of filopodium assembly (GO:0051491)2.62202107
101glial cell proliferation (GO:0014009)2.62026565
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59719418
103negative regulation of systemic arterial blood pressure (GO:0003085)2.59643699
104cell proliferation in forebrain (GO:0021846)2.59599422
105regulation of meiosis I (GO:0060631)2.59503149
106cell communication involved in cardiac conduction (GO:0086065)2.59340234
107axonogenesis (GO:0007409)2.58071704
108regulation of postsynaptic membrane potential (GO:0060078)2.57030856
109protein complex biogenesis (GO:0070271)2.55889797
110cilium morphogenesis (GO:0060271)2.55397876
111cilium organization (GO:0044782)2.55173729
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.54868517
113neuron projection morphogenesis (GO:0048812)2.54703477
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.54292574
115neuronal action potential (GO:0019228)2.53847647
116cerebral cortex radially oriented cell migration (GO:0021799)2.53007462
117spinal cord motor neuron differentiation (GO:0021522)2.52872242
118otic vesicle formation (GO:0030916)2.52762859
119positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.52561821
120sulfation (GO:0051923)2.52460457
121appendage development (GO:0048736)2.51595449
122limb development (GO:0060173)2.51595449
123behavioral defense response (GO:0002209)2.50570143
124behavioral fear response (GO:0001662)2.50570143
125clathrin coat assembly (GO:0048268)2.50449847
126head development (GO:0060322)2.50374905
127regulation of excitatory postsynaptic membrane potential (GO:0060079)2.49924954
128neuron migration (GO:0001764)2.49487387
129hippocampus development (GO:0021766)2.49431739
130cerebellum development (GO:0021549)2.49228201
131prostate gland growth (GO:0060736)2.48502243
132epithelial tube formation (GO:0072175)2.47901345
133membrane depolarization during action potential (GO:0086010)2.47265294
134positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47195843
135long-term memory (GO:0007616)2.47169415
136ephrin receptor signaling pathway (GO:0048013)2.46612298
137positive regulation of dendritic spine morphogenesis (GO:0061003)2.46544833
138regulation of nuclear cell cycle DNA replication (GO:0033262)2.46391994
139regulation of axon extension (GO:0030516)2.45103736
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45086337
141negative regulation of axon guidance (GO:1902668)2.44752981
142regulation of dendritic spine development (GO:0060998)2.44377742
143negative regulation of membrane potential (GO:0045837)2.44152531
144positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.44088986
145regulation of neuron migration (GO:2001222)2.43680902
146primary amino compound metabolic process (GO:1901160)2.43386428
147cornea development in camera-type eye (GO:0061303)2.43163375
148regulation of cilium movement (GO:0003352)2.42934706
149positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.42744226
150C4-dicarboxylate transport (GO:0015740)2.42551337
151negative regulation of microtubule polymerization (GO:0031115)2.42298506
152vesicle transport along microtubule (GO:0047496)2.41497934
153axoneme assembly (GO:0035082)2.41435883
154negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41068887
155negative regulation of translation, ncRNA-mediated (GO:0040033)2.41068887
156regulation of translation, ncRNA-mediated (GO:0045974)2.41068887
157cilium assembly (GO:0042384)2.39284010
158DNA damage response, detection of DNA damage (GO:0042769)2.38300533
159tachykinin receptor signaling pathway (GO:0007217)2.38168529
160synaptic vesicle endocytosis (GO:0048488)2.38049519
161fear response (GO:0042596)2.37678934
162forebrain neuron differentiation (GO:0021879)2.37634843
163cellular response to prostaglandin stimulus (GO:0071379)2.37487520
164cilium movement (GO:0003341)2.36554598
165mechanosensory behavior (GO:0007638)2.36547599
166prepulse inhibition (GO:0060134)2.36338807
167organelle transport along microtubule (GO:0072384)2.35528366
168intraspecies interaction between organisms (GO:0051703)2.35527609
169social behavior (GO:0035176)2.35527609
170neuromuscular process controlling balance (GO:0050885)2.35449618
171positive regulation of synapse assembly (GO:0051965)2.34109793
172negative regulation of dendrite development (GO:2000171)2.34003456
173detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.32923722
174photoreceptor cell development (GO:0042461)2.30919810
175dorsal/ventral axis specification (GO:0009950)2.29299860
176mitochondrial respiratory chain complex assembly (GO:0033108)2.28713997
177glycosphingolipid biosynthetic process (GO:0006688)2.27227768
178protein localization to cilium (GO:0061512)2.27170600
179protein neddylation (GO:0045116)2.26941998
180neuronal action potential propagation (GO:0019227)2.25532858
181adaptation of signaling pathway (GO:0023058)2.25193673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88441704
2GBX2_23144817_ChIP-Seq_PC3_Human3.34806802
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80803032
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.63796616
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55487884
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55474460
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53757386
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.42417148
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28157235
10VDR_22108803_ChIP-Seq_LS180_Human2.27827448
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27670210
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27670210
13EWS_26573619_Chip-Seq_HEK293_Human2.23218608
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21963903
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17780880
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.16923224
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15802824
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07867090
19AR_21572438_ChIP-Seq_LNCaP_Human2.06806943
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01469893
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01290564
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98153643
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95706342
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.93940417
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.93174370
26DROSHA_22980978_ChIP-Seq_HELA_Human1.86960370
27* REST_21632747_ChIP-Seq_MESCs_Mouse1.86729118
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86075231
29ZNF274_21170338_ChIP-Seq_K562_Hela1.78492063
30TAF15_26573619_Chip-Seq_HEK293_Human1.72700281
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72062112
32* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71965233
33* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69505048
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69366150
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.69351978
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61818510
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60544931
38* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59882335
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.59668695
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.58980578
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58730495
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58630667
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58234689
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.52639757
45* P300_19829295_ChIP-Seq_ESCs_Human1.51897184
46ER_23166858_ChIP-Seq_MCF-7_Human1.51816802
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50412856
48AHR_22903824_ChIP-Seq_MCF-7_Human1.50389530
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.49782312
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49730329
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47526025
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46214524
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45194730
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45069750
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.44758359
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44322354
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42795007
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42296434
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41763615
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.40954434
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39555352
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.38408190
63* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37579242
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36581331
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35317814
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34635165
67AR_25329375_ChIP-Seq_VCAP_Human1.33145719
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31404384
69* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30097449
70* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29677458
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.28700189
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.26994639
73RNF2_27304074_Chip-Seq_NSC_Mouse1.25563408
74IRF1_19129219_ChIP-ChIP_H3396_Human1.25324752
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23822456
76* STAT3_23295773_ChIP-Seq_U87_Human1.23429193
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23000693
78* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22786181
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20523537
80* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20253875
81FUS_26573619_Chip-Seq_HEK293_Human1.19817932
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.19661318
83* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19535033
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.19481618
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.19333272
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19123655
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17552402
88* AR_19668381_ChIP-Seq_PC3_Human1.17490619
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17093788
90IGF1R_20145208_ChIP-Seq_DFB_Human1.16497740
91BCAT_22108803_ChIP-Seq_LS180_Human1.16177908
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15877777
93* TAL1_26923725_Chip-Seq_HPCs_Mouse1.14978518
94TP53_18474530_ChIP-ChIP_U2OS_Human1.14525430
95TCF4_22108803_ChIP-Seq_LS180_Human1.14448384
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13568114
97* P53_22387025_ChIP-Seq_ESCs_Mouse1.13290274
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12943472
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.12818400
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12507238
101TP53_16413492_ChIP-PET_HCT116_Human1.12259604
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11319638
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11023527
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10811158
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10811158
106* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08997075
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08714338
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08293132
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.07815660
110* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07779720
111RUNX2_22187159_ChIP-Seq_PCA_Human1.07428543
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.07203053
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.06398550
114JUN_21703547_ChIP-Seq_K562_Human1.05821148
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04930511
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.04446271
117TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03626855
118TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03621710
119SOX2_19829295_ChIP-Seq_ESCs_Human1.03236792
120NANOG_19829295_ChIP-Seq_ESCs_Human1.03236792
121* KDM2B_26808549_Chip-Seq_REH_Human1.02872479
122SMAD_19615063_ChIP-ChIP_OVARY_Human1.02112446
123TCF4_23295773_ChIP-Seq_U87_Human1.01890337
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01653471
125EP300_21415370_ChIP-Seq_HL-1_Mouse1.01291787
126* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01152894
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00679203
128MYC_18940864_ChIP-ChIP_HL60_Human0.99823014
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99050885
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.98436432
131* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97457852
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96388814
133* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96269290
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.95968523
135TRIM28_21343339_ChIP-Seq_HEK293_Human0.95315025
136CBP_20019798_ChIP-Seq_JUKART_Human0.94898409
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94898409
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.94518776
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94343901
140* ISL1_27105846_Chip-Seq_CPCs_Mouse0.93986908
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93228317
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90977010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.06099004
2MP0004270_analgesia3.87005540
3MP0003880_abnormal_central_pattern3.28238787
4MP0003635_abnormal_synaptic_transmissio3.12048009
5MP0000778_abnormal_nervous_system2.88362231
6MP0002063_abnormal_learning/memory/cond2.77726133
7MP0000569_abnormal_digit_pigmentation2.50584200
8MP0003646_muscle_fatigue2.49417756
9MP0009780_abnormal_chondrocyte_physiolo2.32421104
10MP0002102_abnormal_ear_morphology2.31997772
11MP0006292_abnormal_olfactory_placode2.25482948
12MP0005423_abnormal_somatic_nervous2.25062239
13MP0003122_maternal_imprinting2.24481647
14MP0002184_abnormal_innervation2.23433292
15MP0009745_abnormal_behavioral_response2.20514255
16MP0002734_abnormal_mechanical_nocicepti2.14832175
17MP0002572_abnormal_emotion/affect_behav2.13629332
18MP0001968_abnormal_touch/_nociception2.11876848
19MP0006276_abnormal_autonomic_nervous2.03407243
20MP0005187_abnormal_penis_morphology1.97263079
21MP0010234_abnormal_vibrissa_follicle1.96908407
22MP0001529_abnormal_vocalization1.96237472
23MP0001486_abnormal_startle_reflex1.93303179
24MP0000049_abnormal_middle_ear1.87221032
25MP0001984_abnormal_olfaction1.85052351
26MP0001485_abnormal_pinna_reflex1.81673781
27MP0002064_seizures1.80786205
28MP0008877_abnormal_DNA_methylation1.76160433
29MP0001440_abnormal_grooming_behavior1.75953430
30MP0002938_white_spotting1.70849295
31MP0006072_abnormal_retinal_apoptosis1.70095380
32MP0002733_abnormal_thermal_nociception1.67079512
33MP0002557_abnormal_social/conspecific_i1.66122112
34MP0004811_abnormal_neuron_physiology1.60413621
35MP0005551_abnormal_eye_electrophysiolog1.60194982
36MP0005248_abnormal_Harderian_gland1.60124925
37MP0009046_muscle_twitch1.58564851
38MP0002653_abnormal_ependyma_morphology1.50987318
39MP0008961_abnormal_basal_metabolism1.48063095
40MP0002735_abnormal_chemical_nociception1.43947634
41MP0002067_abnormal_sensory_capabilities1.42815076
42MP0001502_abnormal_circadian_rhythm1.39410005
43MP0000955_abnormal_spinal_cord1.39402571
44MP0000537_abnormal_urethra_morphology1.37686804
45MP0003195_calcinosis1.36930699
46MP0005253_abnormal_eye_physiology1.36352054
47MP0003937_abnormal_limbs/digits/tail_de1.34087375
48MP0002272_abnormal_nervous_system1.33341938
49MP0002736_abnormal_nociception_after1.31946115
50MP0004924_abnormal_behavior1.30375146
51MP0005386_behavior/neurological_phenoty1.30375146
52MP0002882_abnormal_neuron_morphology1.27334573
53MP0001299_abnormal_eye_distance/1.26117407
54MP0004858_abnormal_nervous_system1.26001303
55MP0005499_abnormal_olfactory_system1.24507569
56MP0005394_taste/olfaction_phenotype1.24507569
57MP0001970_abnormal_pain_threshold1.23457818
58MP0003938_abnormal_ear_development1.21917961
59MP0003011_delayed_dark_adaptation1.21891026
60MP0002282_abnormal_trachea_morphology1.18573260
61MP0008058_abnormal_DNA_repair1.18113711
62MP0003787_abnormal_imprinting1.17132193
63MP0003121_genomic_imprinting1.17038085
64MP0001293_anophthalmia1.14897049
65MP0002909_abnormal_adrenal_gland1.14366053
66MP0004885_abnormal_endolymph1.12900708
67MP0003879_abnormal_hair_cell1.12794891
68MP0008775_abnormal_heart_ventricle1.12531953
69* MP0002152_abnormal_brain_morphology1.11974520
70MP0002638_abnormal_pupillary_reflex1.11920665
71MP0001501_abnormal_sleep_pattern1.11479011
72MP0004142_abnormal_muscle_tone1.10294422
73* MP0004133_heterotaxia1.08927662
74MP0008789_abnormal_olfactory_epithelium1.08435311
75MP0002066_abnormal_motor_capabilities/c1.06921943
76MP0000751_myopathy1.05952895
77MP0008872_abnormal_physiological_respon1.05505021
78MP0000026_abnormal_inner_ear1.04754080
79MP0005670_abnormal_white_adipose1.02932227
80MP0002160_abnormal_reproductive_system1.02868960
81MP0003385_abnormal_body_wall1.01543922
82MP0004130_abnormal_muscle_cell1.01489146
83MP0003861_abnormal_nervous_system1.00310237
84MP0002837_dystrophic_cardiac_calcinosis0.99985989
85* MP0003755_abnormal_palate_morphology0.99082119
86MP0002234_abnormal_pharynx_morphology0.98520383
87MP0008569_lethality_at_weaning0.97633402
88MP0003137_abnormal_impulse_conducting0.97148018
89MP0001177_atelectasis0.96703879
90MP0001963_abnormal_hearing_physiology0.95032954
91MP0003567_abnormal_fetal_cardiomyocyte0.94449450
92MP0005195_abnormal_posterior_eye0.94412037
93MP0000631_abnormal_neuroendocrine_gland0.94186088
94MP0005645_abnormal_hypothalamus_physiol0.94031726
95MP0002822_catalepsy0.93518018
96MP0005085_abnormal_gallbladder_physiolo0.93419755
97MP0003119_abnormal_digestive_system0.92635190
98MP0009053_abnormal_anal_canal0.92442071
99MP0004085_abnormal_heartbeat0.91443251
100MP0003329_amyloid_beta_deposits0.91051587
101MP0000372_irregular_coat_pigmentation0.90297982
102* MP0003890_abnormal_embryonic-extraembry0.88677204
103MP0004145_abnormal_muscle_electrophysio0.88523109
104MP0005360_urolithiasis0.87689766
105MP0004233_abnormal_muscle_weight0.87148685
106MP0005275_abnormal_skin_tensile0.83689802
107MP0005389_reproductive_system_phenotype0.83665581
108MP0000579_abnormal_nail_morphology0.83641774
109MP0005365_abnormal_bile_salt0.82998845
110MP0002928_abnormal_bile_duct0.82649031
111MP0000647_abnormal_sebaceous_gland0.81157904
112MP0002069_abnormal_eating/drinking_beha0.81032589
113MP0009250_abnormal_appendicular_skeleto0.80680327
114MP0002751_abnormal_autonomic_nervous0.80384809
115MP0003718_maternal_effect0.80266423
116MP0005646_abnormal_pituitary_gland0.80045125
117MP0002876_abnormal_thyroid_physiology0.79912382
118MP0003942_abnormal_urinary_system0.77814498
119MP0002139_abnormal_hepatobiliary_system0.77406180
120MP0000516_abnormal_urinary_system0.77398615
121MP0005367_renal/urinary_system_phenotyp0.77398615
122MP0001849_ear_inflammation0.77332924
123MP0000534_abnormal_ureter_morphology0.77225806
124MP0005391_vision/eye_phenotype0.76926991
125MP0003705_abnormal_hypodermis_morpholog0.76323111
126MP0000538_abnormal_urinary_bladder0.76260908
127MP0002752_abnormal_somatic_nervous0.74441705
128MP0002233_abnormal_nose_morphology0.73016613
129MP0010386_abnormal_urinary_bladder0.72762856
130MP0003252_abnormal_bile_duct0.72092452
131MP0004742_abnormal_vestibular_system0.71459796
132MP0004215_abnormal_myocardial_fiber0.69745021
133MP0009384_cardiac_valve_regurgitation0.69402824
134MP0002090_abnormal_vision0.68092926
135* MP0002081_perinatal_lethality0.67943500
136MP0000013_abnormal_adipose_tissue0.67135382
137MP0003283_abnormal_digestive_organ0.66749869
138MP0001188_hyperpigmentation0.63148061
139MP0003633_abnormal_nervous_system0.62690496

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.41154374
2Focal seizures (HP:0007359)3.94747887
3True hermaphroditism (HP:0010459)3.45605137
4Hyperglycinemia (HP:0002154)3.32375936
5Drooling (HP:0002307)3.30327479
6Excessive salivation (HP:0003781)3.30327479
7Myokymia (HP:0002411)3.28457210
8Pancreatic cysts (HP:0001737)3.26951778
9Methylmalonic acidemia (HP:0002912)3.23804458
10Pancreatic fibrosis (HP:0100732)3.22418796
11Hepatoblastoma (HP:0002884)3.20089741
12Visual hallucinations (HP:0002367)3.19722400
13Abnormality of midbrain morphology (HP:0002418)3.17743874
14Molar tooth sign on MRI (HP:0002419)3.17743874
15Epileptic encephalopathy (HP:0200134)3.07367862
16Broad-based gait (HP:0002136)2.97085036
17Cutaneous melanoma (HP:0012056)2.96578523
18Nephronophthisis (HP:0000090)2.96505223
19Absence seizures (HP:0002121)2.95730085
20Progressive cerebellar ataxia (HP:0002073)2.90077067
21Agitation (HP:0000713)2.86164861
22Hyperventilation (HP:0002883)2.86058447
23Volvulus (HP:0002580)2.84691519
24Mutism (HP:0002300)2.83682723
25Abnormality of the labia minora (HP:0012880)2.81935192
26Medial flaring of the eyebrow (HP:0010747)2.76088272
27Methylmalonic aciduria (HP:0012120)2.71215317
28Exotropia (HP:0000577)2.66959202
29Termporal pattern (HP:0011008)2.59663891
30Insidious onset (HP:0003587)2.59663891
31Amblyopia (HP:0000646)2.57929260
32Limb dystonia (HP:0002451)2.55770059
33Polyphagia (HP:0002591)2.55271982
34Intestinal atresia (HP:0011100)2.54290286
35Dialeptic seizures (HP:0011146)2.53442000
36Generalized tonic-clonic seizures (HP:0002069)2.52583523
37Abnormality of the renal medulla (HP:0100957)2.51185019
38Genetic anticipation (HP:0003743)2.49968831
39Protruding tongue (HP:0010808)2.49857878
40Action tremor (HP:0002345)2.49230257
41Renal hypoplasia (HP:0000089)2.48321854
42Gait imbalance (HP:0002141)2.46099308
43Impaired vibration sensation in the lower limbs (HP:0002166)2.45469630
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.45133414
45Genital tract atresia (HP:0001827)2.40764873
46Urinary urgency (HP:0000012)2.40214860
47Meningioma (HP:0002858)2.38738298
48Epileptiform EEG discharges (HP:0011182)2.38534990
49Chronic hepatic failure (HP:0100626)2.36607206
50Pendular nystagmus (HP:0012043)2.36186101
51Vaginal atresia (HP:0000148)2.35406355
52Congenital primary aphakia (HP:0007707)2.34552098
53Atonic seizures (HP:0010819)2.33278586
54Bronchomalacia (HP:0002780)2.32941264
55Abnormality of the corticospinal tract (HP:0002492)2.32689734
56EEG with generalized epileptiform discharges (HP:0011198)2.32557662
57Torticollis (HP:0000473)2.30650885
58Supranuclear gaze palsy (HP:0000605)2.30375772
59Poor eye contact (HP:0000817)2.30001776
60Inappropriate behavior (HP:0000719)2.29674328
61Aqueductal stenosis (HP:0002410)2.28251318
62Short tibia (HP:0005736)2.27517447
63Papilledema (HP:0001085)2.26215792
64Hypsarrhythmia (HP:0002521)2.25281758
65Ankle clonus (HP:0011448)2.24608511
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.22825797
67Febrile seizures (HP:0002373)2.20347873
68Nephrogenic diabetes insipidus (HP:0009806)2.19130496
69Abnormality of the lower motor neuron (HP:0002366)2.17361009
70Shoulder girdle muscle weakness (HP:0003547)2.17357189
71Cystic liver disease (HP:0006706)2.17120257
72Urinary bladder sphincter dysfunction (HP:0002839)2.14935404
73Failure to thrive in infancy (HP:0001531)2.14730151
74Small hand (HP:0200055)2.13563996
75Postaxial hand polydactyly (HP:0001162)2.11847412
76Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.09973937
77Short 1st metacarpal (HP:0010034)2.09973937
78Labial hypoplasia (HP:0000066)2.09319160
79Abnormal social behavior (HP:0012433)2.08195176
80Impaired social interactions (HP:0000735)2.08195176
81Sclerocornea (HP:0000647)2.06446105
82Abolished electroretinogram (ERG) (HP:0000550)2.06436516
83Abnormality of serine family amino acid metabolism (HP:0010894)2.06142837
84Abnormality of glycine metabolism (HP:0010895)2.06142837
85Abnormality of salivation (HP:0100755)2.05832749
86Anencephaly (HP:0002323)2.04332428
87Amyotrophic lateral sclerosis (HP:0007354)2.03093555
88Abnormality of the renal cortex (HP:0011035)2.01817209
89Chorioretinal atrophy (HP:0000533)2.01096260
90Absent speech (HP:0001344)2.00959332
91Sleep apnea (HP:0010535)2.00397715
92Preaxial hand polydactyly (HP:0001177)1.99622859
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.98744871
94Gaze-evoked nystagmus (HP:0000640)1.98567229
95Blue irides (HP:0000635)1.98477285
96Ankyloglossia (HP:0010296)1.97807750
97Spastic gait (HP:0002064)1.97686757
98Overgrowth (HP:0001548)1.97125897
99Postaxial foot polydactyly (HP:0001830)1.97082516
100Optic nerve hypoplasia (HP:0000609)1.95232033
101Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94857715
102Hypoplasia of the brainstem (HP:0002365)1.94857715
103Abnormality of vitamin B metabolism (HP:0004340)1.94134565
104Cerebral inclusion bodies (HP:0100314)1.92432274
105Obsessive-compulsive behavior (HP:0000722)1.92282800
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91440662
107Ectopic kidney (HP:0000086)1.91208458
108Depression (HP:0000716)1.91167318
109Supernumerary spleens (HP:0009799)1.90539416
110Abnormality of the astrocytes (HP:0100707)1.90169233
111Astrocytoma (HP:0009592)1.90169233
112Morphological abnormality of the pyramidal tract (HP:0002062)1.89525080
113Hip dysplasia (HP:0001385)1.89205760
114Akinesia (HP:0002304)1.88704732
115Stereotypic behavior (HP:0000733)1.88648587
116Type II lissencephaly (HP:0007260)1.88414579
117Buphthalmos (HP:0000557)1.88146425
118Increased corneal curvature (HP:0100692)1.87605843
119Keratoconus (HP:0000563)1.87605843
120Glioma (HP:0009733)1.87552254
121Truncal ataxia (HP:0002078)1.87022916
122Focal dystonia (HP:0004373)1.86858989
123Congenital sensorineural hearing impairment (HP:0008527)1.86253096
124Ependymoma (HP:0002888)1.86114976
125Abnormal eating behavior (HP:0100738)1.85542327
126Septo-optic dysplasia (HP:0100842)1.83980789
127Cortical dysplasia (HP:0002539)1.83808411
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.83724090
129Abnormality of serum amino acid levels (HP:0003112)1.83003941
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.82806598
131Megalencephaly (HP:0001355)1.82048299
132Narrow forehead (HP:0000341)1.81849174
133Hypoplastic pelvis (HP:0008839)1.81744183
134Abnormality of the 1st metacarpal (HP:0010009)1.81709629
135Abnormality of the middle phalanges of the toes (HP:0010183)1.81339158
136Carpal bone hypoplasia (HP:0001498)1.80699507
137Bifid tongue (HP:0010297)1.79381306
138Lower limb muscle weakness (HP:0007340)1.78845845
139Tented upper lip vermilion (HP:0010804)1.78518508
140Open mouth (HP:0000194)1.77772359
141Abnormal lung lobation (HP:0002101)1.77216029
142Obstructive sleep apnea (HP:0002870)1.76463072
143Fetal akinesia sequence (HP:0001989)1.76428643
144Lower limb amyotrophy (HP:0007210)1.75805776
145Craniofacial dystonia (HP:0012179)1.73911056
146Hypoventilation (HP:0002791)1.73806269
147Male pseudohermaphroditism (HP:0000037)1.72036973
148Congenital stationary night blindness (HP:0007642)1.71985182
149Benign neoplasm of the central nervous system (HP:0100835)1.71420689
150Pachygyria (HP:0001302)1.71045734
151Fair hair (HP:0002286)1.70388864
152Anophthalmia (HP:0000528)1.70273809
153Gastrointestinal atresia (HP:0002589)1.70270178
154Abnormality of the parathyroid morphology (HP:0011766)1.70268879
155Occipital encephalocele (HP:0002085)1.69676016
156Lymphangioma (HP:0100764)1.69256572
157Hypothermia (HP:0002045)1.69039742
158Congenital hepatic fibrosis (HP:0002612)1.68588170
159Oligodactyly (hands) (HP:0001180)1.68499383
160Poor coordination (HP:0002370)1.68396552
161Neoplasm of the adrenal cortex (HP:0100641)1.68085548
162Generalized hypopigmentation of hair (HP:0011358)1.68081675
163Papillary thyroid carcinoma (HP:0002895)1.67827493
164Abnormal ciliary motility (HP:0012262)1.67447045
165Specific learning disability (HP:0001328)1.66200743
166Sudden death (HP:0001699)1.66025851
167Neurofibrillary tangles (HP:0002185)1.65740990
168Sporadic (HP:0003745)1.65685785
169Shallow orbits (HP:0000586)1.65576627
170Hemiparesis (HP:0001269)1.65374654
171Stenosis of the external auditory canal (HP:0000402)1.65082018
172Anxiety (HP:0000739)1.63875454
173Hypoplastic female external genitalia (HP:0012815)1.63686877
174Elfin facies (HP:0004428)1.63592383
175Hyperthyroidism (HP:0000836)1.62650650
176Absent eyebrow (HP:0002223)1.59017431
177Lissencephaly (HP:0001339)1.58603692
178Sacral dimple (HP:0000960)1.58455834
179Difficulty running (HP:0009046)1.57335942
180Macroorchidism (HP:0000053)1.56697451
181Cutaneous finger syndactyly (HP:0010554)1.55746301
182Dysdiadochokinesis (HP:0002075)1.55672542
183Autism (HP:0000717)1.55352092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.53904270
2NTRK33.72166742
3MAP3K93.58728908
4NTRK23.12767557
5MAP4K23.11035878
6MAP3K42.84610608
7TRIM282.82796047
8FGFR22.77712466
9KSR12.44683503
10MINK12.15438255
11ERBB32.12043757
12EPHA42.07509477
13MAP2K71.97449696
14MAP2K41.94180881
15MAPK131.85996973
16EPHB21.85052538
17ZAK1.81176207
18DAPK21.80899719
19MAP3K21.76495251
20PINK11.64047624
21GRK11.63695555
22NUAK11.63285714
23MKNK21.59825145
24ADRBK21.58979490
25ACVR1B1.55898556
26PAK61.54482360
27TYRO31.51872332
28PHKG11.47565351
29PHKG21.47565351
30DYRK21.43012340
31LATS21.42300269
32BCR1.39574706
33CASK1.36859423
34SIK31.36661558
35MAP3K121.34819308
36PAK31.33326935
37PDGFRA1.31544180
38TNIK1.30983847
39FER1.30145749
40WNK31.30011244
41CSNK1G21.21842465
42PLK31.18910786
43OXSR11.16852383
44STK391.16597533
45SIK21.16144803
46RET1.14766515
47CDK51.12793731
48UHMK11.06129250
49FGFR41.04859502
50KSR20.99817230
51MKNK10.99194100
52PLK20.98071323
53FGFR30.97844099
54PLK40.97079657
55CAMK1G0.96414356
56PNCK0.96405232
57INSRR0.90106371
58BCKDK0.87682216
59MAP3K60.85449162
60FGFR10.84305005
61MARK20.83156033
62FRK0.82397147
63VRK10.80392828
64TAF10.79490112
65EIF2AK30.78575614
66SRPK10.78210455
67NTRK10.77263769
68CCNB10.77055388
69CSNK1A1L0.76348756
70STK110.76252720
71BMPR1B0.75049455
72PLK10.74802129
73DYRK1A0.73643644
74EPHA30.73469219
75PRKCG0.72873188
76DAPK10.72594599
77STK160.72468828
78PRKCZ0.72332255
79ERBB20.71470838
80ICK0.71387017
81CAMKK10.71314620
82TLK10.71253274
83WEE10.70514960
84TGFBR10.70467830
85CAMK2A0.70286560
86CDK30.70157715
87CSNK1G30.67261655
88BRSK20.66391602
89SGK20.66301697
90BUB10.65064247
91SGK2230.64071262
92SGK4940.64071262
93SGK10.63606298
94RIPK10.62540981
95CDK180.62301603
96LATS10.61485439
97WNK40.59689920
98CDK140.59625227
99OBSCN0.56423629
100CAMK2B0.55825074
101PRPF4B0.54936861
102PRKCE0.53514859
103PRKD30.53110759
104CSNK1G10.52697839
105DYRK30.52368499
106PKN10.52158677
107CDK150.51814847
108ADRBK10.51199434
109TIE10.50222962
110CSNK1A10.49367888
111NEK10.47993366
112ATR0.46878781
113ATM0.46483208
114DMPK0.46152278
115TSSK60.45875955
116STK38L0.45633228
117LIMK10.45222872
118CSNK1D0.43465282
119DDR20.43147780
120CDC70.42284111
121RPS6KA40.42253939
122CDC42BPA0.41995280
123STK380.40669797
124MAP3K70.40565010
125CDK11A0.40361256
126SGK30.40256293
127MAP2K10.40202462
128AKT30.40187589
129PTK20.40077422
130PRKACA0.40042296
131STK30.39553613
132PDGFRB0.38412993
133FYN0.38394156
134GRK70.37578426
135BRD40.37401868
136CAMK1D0.37147915
137PRKAA10.36105491
138ERBB40.35345305
139ROCK10.35228849
140MST1R0.35077597
141RPS6KA30.33736760
142CAMKK20.33719029
143CAMK40.33580644
144TAOK10.33240138
145MAPK90.32924697
146CSNK1E0.32909088
147MUSK0.32862055
148PIK3CA0.32830021
149MST40.32599780
150CAMK10.32211558
151PRKG10.32020336

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.86705342
2Protein export_Homo sapiens_hsa030602.19792072
3Circadian entrainment_Homo sapiens_hsa047132.19317232
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16400878
5Long-term potentiation_Homo sapiens_hsa047202.07390045
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07064380
7Propanoate metabolism_Homo sapiens_hsa006402.06716103
8Fanconi anemia pathway_Homo sapiens_hsa034602.02675190
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99899838
10Axon guidance_Homo sapiens_hsa043601.99896848
11Basal transcription factors_Homo sapiens_hsa030221.97817291
12Synaptic vesicle cycle_Homo sapiens_hsa047211.93950402
13Glutamatergic synapse_Homo sapiens_hsa047241.91734644
14Amphetamine addiction_Homo sapiens_hsa050311.90357226
15GABAergic synapse_Homo sapiens_hsa047271.89998400
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89601197
17Dopaminergic synapse_Homo sapiens_hsa047281.88729426
18Steroid biosynthesis_Homo sapiens_hsa001001.85873522
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75904606
20Insulin secretion_Homo sapiens_hsa049111.72778262
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66687761
22Olfactory transduction_Homo sapiens_hsa047401.65046415
23Renin secretion_Homo sapiens_hsa049241.63189310
24Morphine addiction_Homo sapiens_hsa050321.60379072
25Cocaine addiction_Homo sapiens_hsa050301.58234763
26Type II diabetes mellitus_Homo sapiens_hsa049301.58068105
27Linoleic acid metabolism_Homo sapiens_hsa005911.55114786
28Cholinergic synapse_Homo sapiens_hsa047251.54292749
29Non-homologous end-joining_Homo sapiens_hsa034501.54185737
30Sulfur metabolism_Homo sapiens_hsa009201.49784100
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48239555
32Tryptophan metabolism_Homo sapiens_hsa003801.47054086
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45136306
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44406784
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42663535
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41837559
37RNA degradation_Homo sapiens_hsa030181.38304299
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37919927
39Oxytocin signaling pathway_Homo sapiens_hsa049211.33756106
40Nitrogen metabolism_Homo sapiens_hsa009101.33187681
41Ether lipid metabolism_Homo sapiens_hsa005651.33151156
42Caffeine metabolism_Homo sapiens_hsa002321.32563406
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31086887
44Salivary secretion_Homo sapiens_hsa049701.30400489
45Gap junction_Homo sapiens_hsa045401.29331040
46Taste transduction_Homo sapiens_hsa047421.28793107
47GnRH signaling pathway_Homo sapiens_hsa049121.27643896
48Long-term depression_Homo sapiens_hsa047301.26049584
49Gastric acid secretion_Homo sapiens_hsa049711.25016469
50ErbB signaling pathway_Homo sapiens_hsa040121.23875622
51Serotonergic synapse_Homo sapiens_hsa047261.22270956
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20446447
53Melanogenesis_Homo sapiens_hsa049161.19227693
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18564876
55Oxidative phosphorylation_Homo sapiens_hsa001901.18523870
56Glioma_Homo sapiens_hsa052141.18400681
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16753195
58Retinol metabolism_Homo sapiens_hsa008301.16085544
59Homologous recombination_Homo sapiens_hsa034401.15625589
60RNA polymerase_Homo sapiens_hsa030201.15031542
61Calcium signaling pathway_Homo sapiens_hsa040201.10012654
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09032529
63Peroxisome_Homo sapiens_hsa041461.08429445
64Estrogen signaling pathway_Homo sapiens_hsa049151.08358245
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06660810
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05711981
67Fatty acid elongation_Homo sapiens_hsa000621.04626788
68Fat digestion and absorption_Homo sapiens_hsa049751.04542697
69Butanoate metabolism_Homo sapiens_hsa006501.02199705
70Chemical carcinogenesis_Homo sapiens_hsa052041.01977397
71Selenocompound metabolism_Homo sapiens_hsa004501.01500223
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99827014
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.99549956
74Regulation of autophagy_Homo sapiens_hsa041400.97933198
75Dorso-ventral axis formation_Homo sapiens_hsa043200.95847684
76cAMP signaling pathway_Homo sapiens_hsa040240.95478236
77Endometrial cancer_Homo sapiens_hsa052130.95288729
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.92346510
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92115456
80Parkinsons disease_Homo sapiens_hsa050120.90687482
81Dilated cardiomyopathy_Homo sapiens_hsa054140.89656219
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86997418
83Collecting duct acid secretion_Homo sapiens_hsa049660.85585557
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84660506
85mTOR signaling pathway_Homo sapiens_hsa041500.84501793
86Glucagon signaling pathway_Homo sapiens_hsa049220.84004922
87Glycerolipid metabolism_Homo sapiens_hsa005610.83306347
88Wnt signaling pathway_Homo sapiens_hsa043100.82233712
89Bile secretion_Homo sapiens_hsa049760.81906266
90Circadian rhythm_Homo sapiens_hsa047100.81158812
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80120571
92Hippo signaling pathway_Homo sapiens_hsa043900.79817465
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78421280
94Prion diseases_Homo sapiens_hsa050200.77641835
95Arginine biosynthesis_Homo sapiens_hsa002200.77500001
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77038410
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76888346
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75857307
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75665597
100Insulin signaling pathway_Homo sapiens_hsa049100.74123135
101Basal cell carcinoma_Homo sapiens_hsa052170.73278582
102Base excision repair_Homo sapiens_hsa034100.73008791
103Hedgehog signaling pathway_Homo sapiens_hsa043400.70805733
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69511912
105MAPK signaling pathway_Homo sapiens_hsa040100.69175601
106* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69074413
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69020369
108Choline metabolism in cancer_Homo sapiens_hsa052310.68628802
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68627544
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68453128
111Huntingtons disease_Homo sapiens_hsa050160.68048238
112Oocyte meiosis_Homo sapiens_hsa041140.67458475
113beta-Alanine metabolism_Homo sapiens_hsa004100.67404466
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67380611
115Colorectal cancer_Homo sapiens_hsa052100.67340835
116Renal cell carcinoma_Homo sapiens_hsa052110.67335206
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67291950
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.67241007
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66320447
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.65580173
121Cardiac muscle contraction_Homo sapiens_hsa042600.65573845
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65396771
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65010677
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64579228
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.63360829
126VEGF signaling pathway_Homo sapiens_hsa043700.63272737
127Adherens junction_Homo sapiens_hsa045200.62033794
128Ras signaling pathway_Homo sapiens_hsa040140.62022720
129Pyruvate metabolism_Homo sapiens_hsa006200.61411146
130Fatty acid metabolism_Homo sapiens_hsa012120.61223902
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61076147
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61046619
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60502352
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60393076
135Nucleotide excision repair_Homo sapiens_hsa034200.59561535
136Rap1 signaling pathway_Homo sapiens_hsa040150.58896911
137Insulin resistance_Homo sapiens_hsa049310.58666763
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57618176
139Vitamin digestion and absorption_Homo sapiens_hsa049770.57458173
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.56805248
141Metabolic pathways_Homo sapiens_hsa011000.56017105
142Thyroid hormone synthesis_Homo sapiens_hsa049180.55376222
143Phototransduction_Homo sapiens_hsa047440.55281869
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55279369
145Fatty acid degradation_Homo sapiens_hsa000710.55197156
146AMPK signaling pathway_Homo sapiens_hsa041520.55172310
147Alzheimers disease_Homo sapiens_hsa050100.54544567
148Mismatch repair_Homo sapiens_hsa034300.51451929
149Pancreatic secretion_Homo sapiens_hsa049720.49938151
150Proteoglycans in cancer_Homo sapiens_hsa052050.46583884
151* TGF-beta signaling pathway_Homo sapiens_hsa043500.46468256
152Tight junction_Homo sapiens_hsa045300.45176071
153Fatty acid biosynthesis_Homo sapiens_hsa000610.45013198
154RNA transport_Homo sapiens_hsa030130.43763272
155Purine metabolism_Homo sapiens_hsa002300.43290966
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.42482734
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42013866
158Vibrio cholerae infection_Homo sapiens_hsa051100.41672048
159Non-small cell lung cancer_Homo sapiens_hsa052230.41152147
160Focal adhesion_Homo sapiens_hsa045100.40910743
161Central carbon metabolism in cancer_Homo sapiens_hsa052300.40590067
162Sphingolipid signaling pathway_Homo sapiens_hsa040710.40249347
163Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39852604

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