ACVR2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine dimer repair (GO:0006290)6.28101273
2negative regulation of telomere maintenance (GO:0032205)5.46219983
3regulation of telomere maintenance via telomerase (GO:0032210)4.55182887
4viral transcription (GO:0019083)4.39987892
5establishment of integrated proviral latency (GO:0075713)4.22342717
6multicellular organismal aging (GO:0010259)4.20587245
7translational termination (GO:0006415)4.19770066
8DNA unwinding involved in DNA replication (GO:0006268)4.10274243
9negative regulation of translation, ncRNA-mediated (GO:0040033)4.08673906
10regulation of translation, ncRNA-mediated (GO:0045974)4.08673906
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.08673906
12spliceosomal snRNP assembly (GO:0000387)3.93584744
13regulation of gene silencing by RNA (GO:0060966)3.93448007
14regulation of posttranscriptional gene silencing (GO:0060147)3.93448007
15regulation of gene silencing by miRNA (GO:0060964)3.93448007
16DNA damage induced protein phosphorylation (GO:0006975)3.93101495
17spliceosomal complex assembly (GO:0000245)3.90146405
18negative regulation of telomerase activity (GO:0051974)3.86999435
19somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.82954003
20somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.82954003
21isotype switching (GO:0045190)3.82954003
22maturation of SSU-rRNA (GO:0030490)3.72341636
23translational elongation (GO:0006414)3.68885862
24cell proliferation in forebrain (GO:0021846)3.68420707
25ribosomal small subunit biogenesis (GO:0042274)3.65963956
26presynaptic membrane assembly (GO:0097105)3.64148552
27paraxial mesoderm development (GO:0048339)3.63378521
28mitotic recombination (GO:0006312)3.62998108
29transcription-coupled nucleotide-excision repair (GO:0006283)3.61315909
30dorsal/ventral axis specification (GO:0009950)3.61192777
31substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.60190043
32substrate-independent telencephalic tangential migration (GO:0021826)3.60190043
33translational initiation (GO:0006413)3.59114215
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58293347
35mitotic metaphase plate congression (GO:0007080)3.55730035
36cell migration in hindbrain (GO:0021535)3.51458716
37pre-miRNA processing (GO:0031054)3.48045365
38limb bud formation (GO:0060174)3.47711817
39regulation of telomere maintenance (GO:0032204)3.47488763
40DNA strand elongation involved in DNA replication (GO:0006271)3.45944272
41pyrimidine nucleobase catabolic process (GO:0006208)3.40626801
42ventricular trabecula myocardium morphogenesis (GO:0003222)3.39768153
43ribosomal large subunit biogenesis (GO:0042273)3.39636313
44cellular protein complex disassembly (GO:0043624)3.37664503
45DNA strand elongation (GO:0022616)3.36892887
46viral life cycle (GO:0019058)3.34921317
47DNA replication-dependent nucleosome assembly (GO:0006335)3.33705261
48DNA replication-dependent nucleosome organization (GO:0034723)3.33705261
49protein complex disassembly (GO:0043241)3.33563054
50protein-DNA complex disassembly (GO:0032986)3.32212643
51nucleosome disassembly (GO:0006337)3.32212643
52presynaptic membrane organization (GO:0097090)3.31839147
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29010345
54DNA damage response, detection of DNA damage (GO:0042769)3.28860750
55histone arginine methylation (GO:0034969)3.27450047
56viral mRNA export from host cell nucleus (GO:0046784)3.25122264
57negative regulation of histone methylation (GO:0031061)3.24315722
58cotranslational protein targeting to membrane (GO:0006613)3.23442657
59formation of translation preinitiation complex (GO:0001731)3.21762258
60protein complex localization (GO:0031503)3.21486177
61protein targeting to ER (GO:0045047)3.20158067
62heterochromatin organization (GO:0070828)3.20139108
63macromolecular complex disassembly (GO:0032984)3.18586255
64peptidyl-arginine omega-N-methylation (GO:0035247)3.17367587
65hindbrain development (GO:0030902)3.15321738
66metaphase plate congression (GO:0051310)3.11462911
67UV protection (GO:0009650)3.10870398
68somatic recombination of immunoglobulin gene segments (GO:0016447)3.10825217
69histone H2A acetylation (GO:0043968)3.10808048
70DNA replication-independent nucleosome organization (GO:0034724)3.10766675
71DNA replication-independent nucleosome assembly (GO:0006336)3.10766675
72positive regulation of interleukin-8 secretion (GO:2000484)3.07145751
73regulation of development, heterochronic (GO:0040034)3.06875900
74DNA replication checkpoint (GO:0000076)3.06685806
75kinetochore assembly (GO:0051382)3.06221422
76nucleotide-excision repair, DNA damage removal (GO:0000718)3.05851118
77DNA excision (GO:0044349)3.05851118
78lateral sprouting from an epithelium (GO:0060601)3.05649833
79regulation of timing of cell differentiation (GO:0048505)3.04788590
80DNA replication initiation (GO:0006270)3.04300029
81ribosomal small subunit assembly (GO:0000028)3.02986031
82telomere maintenance via telomerase (GO:0007004)3.01107143
83establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00886056
84somite development (GO:0061053)2.98329969
85establishment of viral latency (GO:0019043)2.90798593
86protein localization to endoplasmic reticulum (GO:0070972)2.89746820
87ribonucleoprotein complex biogenesis (GO:0022613)2.89073692
88kinetochore organization (GO:0051383)2.88934342
89mRNA splicing, via spliceosome (GO:0000398)2.88911424
90RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88911424
91regulation of histone H3-K9 methylation (GO:0051570)2.87938535
92RNA splicing, via transesterification reactions (GO:0000375)2.86643842
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86361004
94nuclear-transcribed mRNA catabolic process (GO:0000956)2.86157642
95DNA integration (GO:0015074)2.85892650
96negative regulation of RNA splicing (GO:0033119)2.85433489
97peptidyl-arginine methylation (GO:0018216)2.83080175
98peptidyl-arginine N-methylation (GO:0035246)2.83080175
99somatic diversification of immunoglobulins (GO:0016445)2.82449176
100telomere maintenance via semi-conservative replication (GO:0032201)2.81692726
101regulation of cell fate specification (GO:0042659)2.81112525
102pituitary gland development (GO:0021983)2.80636503
103ATP-dependent chromatin remodeling (GO:0043044)2.79754743
104kidney morphogenesis (GO:0060993)2.78533614
105CENP-A containing nucleosome assembly (GO:0034080)2.76188494
106chromatin remodeling at centromere (GO:0031055)2.75424866
107chromatin assembly or disassembly (GO:0006333)2.75283341
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72872703
109cornea development in camera-type eye (GO:0061303)2.72107056
110spinal cord development (GO:0021510)2.71127782
111regulation of double-strand break repair via homologous recombination (GO:0010569)2.69271637
112axonal fasciculation (GO:0007413)2.69230695
113translation (GO:0006412)2.68614521
114lung-associated mesenchyme development (GO:0060484)2.68539106
115mRNA catabolic process (GO:0006402)2.68079759
116heart trabecula morphogenesis (GO:0061384)2.68029895
117regulation of mesoderm development (GO:2000380)2.67718990
118DNA deamination (GO:0045006)2.66766671
119nucleobase biosynthetic process (GO:0046112)2.66170034
120protein localization to kinetochore (GO:0034501)2.65063263
121regulation of helicase activity (GO:0051095)2.63635104
122rRNA processing (GO:0006364)2.63047721
123otic vesicle formation (GO:0030916)2.62711771
124inner ear receptor cell development (GO:0060119)2.62362769
125response to X-ray (GO:0010165)2.61436914
126epithelial cell fate commitment (GO:0072148)2.60391638
127somatic cell DNA recombination (GO:0016444)2.60255156
128somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.60255156
129ribonucleoprotein complex assembly (GO:0022618)2.60141958
130termination of RNA polymerase II transcription (GO:0006369)2.59061293
131rRNA modification (GO:0000154)2.58495358
132histone exchange (GO:0043486)2.57358713
133neuron cell-cell adhesion (GO:0007158)2.57197425
134nucleobase catabolic process (GO:0046113)2.57138808
135* gastrulation with mouth forming second (GO:0001702)2.54563787
136microtubule anchoring (GO:0034453)2.54441377
137single strand break repair (GO:0000012)2.54060614
138neuronal stem cell maintenance (GO:0097150)2.53657395
139retinal ganglion cell axon guidance (GO:0031290)2.50589769
140regulation of DNA methylation (GO:0044030)2.49782385
141behavioral response to nicotine (GO:0035095)2.49420297
142olfactory bulb development (GO:0021772)2.47447537
143replication fork processing (GO:0031297)2.45216697
144negative regulation of astrocyte differentiation (GO:0048712)2.41541627
145atrial cardiac muscle cell action potential (GO:0086014)2.41399247
146cardiac right ventricle morphogenesis (GO:0003215)2.40632045
147postsynaptic membrane organization (GO:0001941)2.39703160
148forebrain neuron differentiation (GO:0021879)2.39391693
149generation of neurons (GO:0048699)2.38882325
150neuron recognition (GO:0008038)2.38615678
151regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.37762739
152negative regulation of DNA-dependent DNA replication (GO:2000104)2.37569624
153intra-S DNA damage checkpoint (GO:0031573)2.37272989
154somite rostral/caudal axis specification (GO:0032525)2.36962795
155positive regulation of neuroblast proliferation (GO:0002052)2.36579281
156ncRNA catabolic process (GO:0034661)2.35564632
157anterior/posterior axis specification (GO:0009948)2.35346390
158regulation of gene silencing (GO:0060968)2.35185498
159negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.35065807
160layer formation in cerebral cortex (GO:0021819)2.34113965
161dendrite morphogenesis (GO:0048813)2.33934987
162L-serine metabolic process (GO:0006563)2.32698651
163regulation of telomerase activity (GO:0051972)2.32642753
164negative regulation of glial cell differentiation (GO:0045686)2.32563514
165appendage development (GO:0048736)2.30669154
166limb development (GO:0060173)2.30669154
167chromatin assembly (GO:0031497)2.29428496
168NLS-bearing protein import into nucleus (GO:0006607)2.29315659
169histone-serine phosphorylation (GO:0035404)2.28676786
170positive regulation of dendritic spine morphogenesis (GO:0061003)2.28383311
171cell fate commitment involved in formation of primary germ layer (GO:0060795)2.27304516
172notochord development (GO:0030903)2.26853636
173regulation of non-canonical Wnt signaling pathway (GO:2000050)2.26844071
174regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.25403907
175somatic diversification of immune receptors via somatic mutation (GO:0002566)2.23624212
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.23624212
177mitotic sister chromatid cohesion (GO:0007064)2.23591342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.00508078
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.24792543
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.13422947
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.59086600
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.32857094
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27745712
7EZH2_22144423_ChIP-Seq_EOC_Human3.27171823
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.15197625
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96108404
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90329221
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.84697247
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78231120
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78208110
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.73248132
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72341654
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72200052
17XRN2_22483619_ChIP-Seq_HELA_Human2.55829044
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.51845226
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.48931963
20GBX2_23144817_ChIP-Seq_PC3_Human2.44260437
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.44197904
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39775169
23FUS_26573619_Chip-Seq_HEK293_Human2.37584371
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37228946
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36775977
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.32181069
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31817448
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21241472
29SOX2_18555785_ChIP-Seq_MESCs_Mouse2.20669737
30KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.19512459
31EWS_26573619_Chip-Seq_HEK293_Human2.11372411
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10893891
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10592091
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09057487
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.08125814
36TAF15_26573619_Chip-Seq_HEK293_Human2.07998725
37THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03847116
38ZNF274_21170338_ChIP-Seq_K562_Hela2.03257808
39TTF2_22483619_ChIP-Seq_HELA_Human2.01695233
40CBX2_27304074_Chip-Seq_ESCs_Mouse2.01459451
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98403308
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93501968
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91854439
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91524680
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86094661
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82168469
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80681464
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80277777
49P300_19829295_ChIP-Seq_ESCs_Human1.77946658
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.74498859
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73323203
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72593567
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71739155
54RNF2_27304074_Chip-Seq_NSC_Mouse1.67914410
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67536166
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67529033
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67529033
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67529033
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67109884
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66464297
61IGF1R_20145208_ChIP-Seq_DFB_Human1.66405317
62FOXP3_21729870_ChIP-Seq_TREG_Human1.63853463
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61904576
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.61788642
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61186801
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61186801
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.59560395
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59395469
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58803701
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58231586
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57645697
72DCP1A_22483619_ChIP-Seq_HELA_Human1.57440633
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56299172
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56239709
75VDR_23849224_ChIP-Seq_CD4+_Human1.55108938
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54027352
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52970938
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50938143
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49481199
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.49403440
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48895534
82GABP_19822575_ChIP-Seq_HepG2_Human1.48479088
83VDR_22108803_ChIP-Seq_LS180_Human1.44500311
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.43817936
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41292384
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41152339
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.38384128
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36724650
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36252817
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35269849
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.34429513
92* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33411996
93SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32521465
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32426861
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31793362
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31400805
97KDM5A_27292631_Chip-Seq_BREAST_Human1.31260280
98SMAD4_21799915_ChIP-Seq_A2780_Human1.30962413
99* MYC_18940864_ChIP-ChIP_HL60_Human1.29767802
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29281970
101CIITA_25753668_ChIP-Seq_RAJI_Human1.28602131
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27758633
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27415121
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26118217
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24623082
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.24548392
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22792135
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.22698968
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21741847
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21492218
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21156172
112TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20682275
113TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20624052
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19482351
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19206058
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.18299056
117POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17132168
118AR_21572438_ChIP-Seq_LNCaP_Human1.17083425
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16940238
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16697406
121* REST_21632747_ChIP-Seq_MESCs_Mouse1.16438324
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16119079
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15824391
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.14935925
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14926795
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14751694
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14525961
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14259629
129* STAT3_23295773_ChIP-Seq_U87_Human1.13565181
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13185426
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12506121
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11924824
133SOX9_26525672_Chip-Seq_HEART_Mouse1.11428779
134* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10399488
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10030712
136IRF1_19129219_ChIP-ChIP_H3396_Human1.09965020
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08264677
138POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07777635
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07198879
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06724528
141SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06359569
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05429546
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04786457
144RUNX2_22187159_ChIP-Seq_PCA_Human1.04315621
145AR_21909140_ChIP-Seq_LNCAP_Human1.04153802
146RNF2_27304074_Chip-Seq_ESCs_Mouse1.04000820
147ISL1_27105846_Chip-Seq_CPCs_Mouse1.03446481
148TCF4_23295773_ChIP-Seq_U87_Human1.03121389
149* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02196942
150SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01638982
151NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01614455
152CBP_20019798_ChIP-Seq_JUKART_Human1.01392902
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01392902
154EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01214358
155RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01214358
156CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99759558
157ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99585875
158POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98545672
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98427004
160PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98307490
161P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97769218
162NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97561089
163STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97425902
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.97319988
165WT1_19549856_ChIP-ChIP_CCG9911_Human0.96947901
166TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95675440
167CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95217226
168SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94127707
169MYC_22102868_ChIP-Seq_BL_Human0.94020930
170FOXP1_21924763_ChIP-Seq_HESCs_Human0.91292170
171NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90462563
172SRF_21415370_ChIP-Seq_HL-1_Mouse0.90124306
173SOX17_20123909_ChIP-Seq_XEN_Mouse0.89585998
174GATA1_26923725_Chip-Seq_HPCs_Mouse0.88021065
175ELK1_19687146_ChIP-ChIP_HELA_Human0.87419281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.53712772
2MP0003890_abnormal_embryonic-extraembry3.77954622
3MP0003111_abnormal_nucleus_morphology3.09698015
4MP0008058_abnormal_DNA_repair2.93745574
5MP0006292_abnormal_olfactory_placode2.82571107
6MP0000516_abnormal_urinary_system2.79010392
7MP0005367_renal/urinary_system_phenotyp2.79010392
8MP0008007_abnormal_cellular_replicative2.69267551
9MP0003693_abnormal_embryo_hatching2.65659835
10MP0010094_abnormal_chromosome_stability2.63266465
11MP0004957_abnormal_blastocyst_morpholog2.54798415
12MP0002249_abnormal_larynx_morphology2.49314232
13MP0008932_abnormal_embryonic_tissue2.35690117
14MP0002653_abnormal_ependyma_morphology2.33419602
15MP0002102_abnormal_ear_morphology2.31748682
16MP0003077_abnormal_cell_cycle2.26812745
17MP0000537_abnormal_urethra_morphology2.22357454
18* MP0004133_heterotaxia2.21655536
19MP0003315_abnormal_perineum_morphology2.18569439
20MP0003880_abnormal_central_pattern2.14098740
21MP0008877_abnormal_DNA_methylation2.12820771
22MP0003123_paternal_imprinting2.08738098
23MP0003121_genomic_imprinting2.06880559
24MP0004043_abnormal_pH_regulation2.05686950
25MP0004142_abnormal_muscle_tone2.02362722
26MP0003119_abnormal_digestive_system1.98450802
27MP0003122_maternal_imprinting1.94171212
28MP0008789_abnormal_olfactory_epithelium1.90363935
29MP0002638_abnormal_pupillary_reflex1.86391384
30MP0004270_analgesia1.81995700
31MP0003786_premature_aging1.78244541
32MP0000631_abnormal_neuroendocrine_gland1.72145499
33MP0005499_abnormal_olfactory_system1.64597488
34MP0005394_taste/olfaction_phenotype1.64597488
35MP0002751_abnormal_autonomic_nervous1.62601715
36MP0001293_anophthalmia1.62112544
37MP0000049_abnormal_middle_ear1.60343615
38MP0003941_abnormal_skin_development1.57671983
39MP0000350_abnormal_cell_proliferation1.52827391
40MP0001730_embryonic_growth_arrest1.51957554
41MP0002085_abnormal_embryonic_tissue1.50805281
42MP0009053_abnormal_anal_canal1.45560823
43MP0003937_abnormal_limbs/digits/tail_de1.44905782
44MP0009703_decreased_birth_body1.43543732
45MP0005380_embryogenesis_phenotype1.43240745
46MP0001672_abnormal_embryogenesis/_devel1.43240745
47* MP0002084_abnormal_developmental_patter1.42244787
48MP0003861_abnormal_nervous_system1.41166144
49MP0004197_abnormal_fetal_growth/weight/1.40513781
50MP0003938_abnormal_ear_development1.35637274
51MP0001529_abnormal_vocalization1.34115549
52MP0002938_white_spotting1.33778391
53MP0006035_abnormal_mitochondrial_morpho1.32873799
54MP0002697_abnormal_eye_size1.30837330
55MP0009672_abnormal_birth_weight1.30448261
56MP0001286_abnormal_eye_development1.30087538
57MP0005187_abnormal_penis_morphology1.29821386
58MP0001697_abnormal_embryo_size1.28239818
59MP0003283_abnormal_digestive_organ1.23995399
60MP0003984_embryonic_growth_retardation1.23510450
61MP0002088_abnormal_embryonic_growth/wei1.23319735
62MP0002932_abnormal_joint_morphology1.22245021
63MP0002822_catalepsy1.22109865
64MP0003878_abnormal_ear_physiology1.21930533
65MP0005377_hearing/vestibular/ear_phenot1.21930533
66MP0009379_abnormal_foot_pigmentation1.21291811
67MP0000955_abnormal_spinal_cord1.19291375
68MP0000778_abnormal_nervous_system1.18568147
69MP0003385_abnormal_body_wall1.16385162
70MP0003567_abnormal_fetal_cardiomyocyte1.16078787
71MP0002734_abnormal_mechanical_nocicepti1.15430789
72MP0002111_abnormal_tail_morphology1.12229270
73MP0001299_abnormal_eye_distance/1.11109347
74MP0005257_abnormal_intraocular_pressure1.07513489
75MP0005423_abnormal_somatic_nervous1.07462527
76MP0002160_abnormal_reproductive_system1.06790063
77MP0002080_prenatal_lethality1.04126814
78MP0008057_abnormal_DNA_replication1.04115945
79MP0003136_yellow_coat_color1.04017341
80MP0001188_hyperpigmentation1.03426181
81MP0000432_abnormal_head_morphology1.01925420
82MP0000566_synostosis1.01631063
83MP0002210_abnormal_sex_determination1.01412891
84MP0000647_abnormal_sebaceous_gland0.99148710
85MP0002282_abnormal_trachea_morphology0.98866004
86MP0002557_abnormal_social/conspecific_i0.98294310
87MP0009250_abnormal_appendicular_skeleto0.98151024
88MP0005195_abnormal_posterior_eye0.96512348
89MP0009697_abnormal_copulation0.95494533
90MP0006072_abnormal_retinal_apoptosis0.95367465
91MP0002233_abnormal_nose_morphology0.94799080
92MP0003935_abnormal_craniofacial_develop0.93510579
93MP0002116_abnormal_craniofacial_bone0.93034609
94MP0002735_abnormal_chemical_nociception0.92086185
95MP0003755_abnormal_palate_morphology0.91739380
96MP0003195_calcinosis0.90984679
97MP0005253_abnormal_eye_physiology0.90968746
98MP0003718_maternal_effect0.89978127
99* MP0002114_abnormal_axial_skeleton0.89793627
100MP0006276_abnormal_autonomic_nervous0.89267782
101MP0001486_abnormal_startle_reflex0.88807376
102MP0003635_abnormal_synaptic_transmissio0.88805758
103MP0001485_abnormal_pinna_reflex0.88476613
104MP0005551_abnormal_eye_electrophysiolog0.87753479
105MP0002086_abnormal_extraembryonic_tissu0.87239032
106MP0000428_abnormal_craniofacial_morphol0.86017093
107MP0004742_abnormal_vestibular_system0.85953783
108MP0002092_abnormal_eye_morphology0.85945332
109MP0001346_abnormal_lacrimal_gland0.85553896
110MP0005248_abnormal_Harderian_gland0.85542998
111MP0008995_early_reproductive_senescence0.85167285
112MP0003646_muscle_fatigue0.84830431
113MP0009745_abnormal_behavioral_response0.83943141
114MP0002063_abnormal_learning/memory/cond0.83828222
115MP0001984_abnormal_olfaction0.83603679
116MP0004885_abnormal_endolymph0.83097860
117MP0002882_abnormal_neuron_morphology0.83095289
118MP0004811_abnormal_neuron_physiology0.82508517
119MP0003942_abnormal_urinary_system0.82249841
120MP0002234_abnormal_pharynx_morphology0.81483152
121MP0002184_abnormal_innervation0.78471372
122MP0002081_perinatal_lethality0.78463510
123MP0001145_abnormal_male_reproductive0.77170873
124MP0005391_vision/eye_phenotype0.75252516
125MP0000653_abnormal_sex_gland0.73488526
126MP0000313_abnormal_cell_death0.72702315
127MP0002152_abnormal_brain_morphology0.72611380
128MP0003787_abnormal_imprinting0.71812058
129MP0005501_abnormal_skin_physiology0.71401043
130MP0003115_abnormal_respiratory_system0.70678742
131MP0008770_decreased_survivor_rate0.70270859
132MP0002752_abnormal_somatic_nervous0.67740336
133MP0006036_abnormal_mitochondrial_physio0.64578052

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.22917706
2Failure to thrive in infancy (HP:0001531)4.92045045
3Morphological abnormality of the middle ear (HP:0008609)4.20056773
4Hyperacusis (HP:0010780)4.02172304
5Abnormality of cells of the erythroid lineage (HP:0012130)3.92944973
6Abnormal number of incisors (HP:0011064)3.79097158
7Esophageal atresia (HP:0002032)3.75641243
8Abnormal number of erythroid precursors (HP:0012131)3.67265055
9Overlapping toe (HP:0001845)3.63942538
10Medulloblastoma (HP:0002885)3.56406053
11Prominent metopic ridge (HP:0005487)3.44927250
12Abnormality of the metopic suture (HP:0005556)3.36324111
13Reticulocytopenia (HP:0001896)3.28556418
14Macrocytic anemia (HP:0001972)3.22029018
15Broad face (HP:0000283)3.17702108
16Broad alveolar ridges (HP:0000187)3.10900417
17Supernumerary spleens (HP:0009799)3.08738676
18Gastrointestinal atresia (HP:0002589)3.05713976
19Hepatoblastoma (HP:0002884)3.03283279
20Patellar aplasia (HP:0006443)2.86500142
21Colon cancer (HP:0003003)2.86197110
22Optic nerve hypoplasia (HP:0000609)2.84680429
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83088721
24Limb dystonia (HP:0002451)2.81192489
25Abnormality of the labia minora (HP:0012880)2.79091353
26Aplasia/Hypoplasia of the patella (HP:0006498)2.71578238
27Intestinal atresia (HP:0011100)2.71261476
28Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.69595285
29Rib fusion (HP:0000902)2.69352629
30Volvulus (HP:0002580)2.65963891
31Chromsome breakage (HP:0040012)2.65099598
32Tented upper lip vermilion (HP:0010804)2.65003544
33Meckel diverticulum (HP:0002245)2.57392032
34Cutaneous finger syndactyly (HP:0010554)2.49205738
35Truncus arteriosus (HP:0001660)2.47333761
36Abnormality of chromosome segregation (HP:0002916)2.46940018
37Abnormality of the ileum (HP:0001549)2.46613357
38Abnormal lung lobation (HP:0002101)2.41088866
39Supernumerary ribs (HP:0005815)2.40561490
40Aqueductal stenosis (HP:0002410)2.38707296
41Supernumerary bones of the axial skeleton (HP:0009144)2.38038443
42Absent radius (HP:0003974)2.35676439
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.33590069
44Large eyes (HP:0001090)2.30919697
45Cutaneous syndactyly (HP:0012725)2.28620098
46Septo-optic dysplasia (HP:0100842)2.26107251
47Pallor (HP:0000980)2.25066463
48Triphalangeal thumb (HP:0001199)2.23487145
49Horseshoe kidney (HP:0000085)2.22003714
50Absent forearm bone (HP:0003953)2.19992402
51Aplasia involving forearm bones (HP:0009822)2.19992402
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19932615
53Short 4th metacarpal (HP:0010044)2.19932615
54Rhabdomyosarcoma (HP:0002859)2.19736468
55Absent septum pellucidum (HP:0001331)2.19474431
56Hepatocellular necrosis (HP:0001404)2.19441092
57Anophthalmia (HP:0000528)2.18279671
58Abnormality of the radial head (HP:0003995)2.18128262
59Aplastic anemia (HP:0001915)2.16259416
60Cortical dysplasia (HP:0002539)2.15872282
61Dislocated radial head (HP:0003083)2.15162391
62Congenital malformation of the right heart (HP:0011723)2.12693252
63Double outlet right ventricle (HP:0001719)2.12693252
64Anal stenosis (HP:0002025)2.10862727
65Oligodactyly (hands) (HP:0001180)2.09660065
66Birth length less than 3rd percentile (HP:0003561)2.09191502
67Absent thumb (HP:0009777)2.09163391
68Midline defect of the nose (HP:0004122)2.08215113
69Abnormality of the preputium (HP:0100587)2.04458863
70Ectopic kidney (HP:0000086)2.03272769
71Acute necrotizing encephalopathy (HP:0006965)2.01430328
72Preaxial foot polydactyly (HP:0001841)2.00552394
73Renal duplication (HP:0000075)1.97755945
74Chronic hepatic failure (HP:0100626)1.97138056
75Self-mutilation (HP:0000742)1.96050516
76Short philtrum (HP:0000322)1.95503665
77Neoplasm of striated muscle (HP:0009728)1.95001674
78Nephroblastoma (Wilms tumor) (HP:0002667)1.94993221
79Ependymoma (HP:0002888)1.94992775
80Slender long bone (HP:0003100)1.94775799
81Maternal diabetes (HP:0009800)1.94656609
82Renal hypoplasia (HP:0000089)1.93207845
83High anterior hairline (HP:0009890)1.93137043
84Breast hypoplasia (HP:0003187)1.92466973
85True hermaphroditism (HP:0010459)1.92230841
86Cerebral hypomyelination (HP:0006808)1.91755663
87Abdominal situs inversus (HP:0003363)1.91189606
88Abnormality of abdominal situs (HP:0011620)1.91189606
89Mitochondrial inheritance (HP:0001427)1.90054403
90Anencephaly (HP:0002323)1.84707959
91Nephronophthisis (HP:0000090)1.84432817
92Embryonal renal neoplasm (HP:0011794)1.84196776
93Optic nerve coloboma (HP:0000588)1.84114768
94Adducted thumb (HP:0001181)1.83850689
95Broad-based gait (HP:0002136)1.82782793
96Hypoplasia of the fovea (HP:0007750)1.82603376
97Aplasia/Hypoplasia of the fovea (HP:0008060)1.82603376
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.82374273
99Decreased testicular size (HP:0008734)1.82153116
100Pancreatic fibrosis (HP:0100732)1.82113683
101Renal dysplasia (HP:0000110)1.81613938
102Abnormality of the fovea (HP:0000493)1.81456247
103Vitreoretinal degeneration (HP:0000655)1.81359108
104Acute encephalopathy (HP:0006846)1.81024068
105Abnormality of the 4th metacarpal (HP:0010012)1.80349595
106Duodenal stenosis (HP:0100867)1.80336818
107Small intestinal stenosis (HP:0012848)1.80336818
108Degeneration of anterior horn cells (HP:0002398)1.79887420
109Abnormality of the anterior horn cell (HP:0006802)1.79887420
110Bifid tongue (HP:0010297)1.79663969
111Papillary thyroid carcinoma (HP:0002895)1.79177769
112Stenosis of the external auditory canal (HP:0000402)1.78175635
113Carpal bone hypoplasia (HP:0001498)1.77780873
114Pancreatic cysts (HP:0001737)1.77590271
115Selective tooth agenesis (HP:0001592)1.77568929
116Generalized hypotonia (HP:0001290)1.77263571
117Scrotal hypoplasia (HP:0000046)1.77154398
118Abnormality of the middle phalanges of the toes (HP:0010183)1.77003665
119Protruding tongue (HP:0010808)1.76258851
120Tetralogy of Fallot (HP:0001636)1.75997176
121Joint contractures involving the joints of the feet (HP:0100492)1.74699511
122Flexion contracture of toe (HP:0005830)1.74699511
123Broad palm (HP:0001169)1.74474057
124Preaxial hand polydactyly (HP:0001177)1.73739597
125Myelomeningocele (HP:0002475)1.73178204
126Abnormality of the alveolar ridges (HP:0006477)1.72531376
127Oligodactyly (HP:0012165)1.71980026
128Abnormality of the carotid arteries (HP:0005344)1.71893281
129Abnormality of chromosome stability (HP:0003220)1.71452572
130Shawl scrotum (HP:0000049)1.71378651
131Drooling (HP:0002307)1.70825064
132Abnormality of the duodenum (HP:0002246)1.69300400
133Oral leukoplakia (HP:0002745)1.69011526
134Abnormality of cochlea (HP:0000375)1.68703027
135Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68500377
136Labial hypoplasia (HP:0000066)1.68142731
137Abnormality of glycolysis (HP:0004366)1.68038633
138Increased serum pyruvate (HP:0003542)1.68038633
139Tracheoesophageal fistula (HP:0002575)1.68009843
140Hemivertebrae (HP:0002937)1.67738059
141Cupped ear (HP:0000378)1.67389701
142Abnormality of the septum pellucidum (HP:0007375)1.67330196
143Morphological abnormality of the inner ear (HP:0011390)1.66879609
144Choanal stenosis (HP:0000452)1.66783769
145Prominent nasal bridge (HP:0000426)1.66552008
146Dandy-Walker malformation (HP:0001305)1.66218387
147Abnormality of the intervertebral disk (HP:0005108)1.66186017
148Partial agenesis of the corpus callosum (HP:0001338)1.66107737
149Duplication of thumb phalanx (HP:0009942)1.65791608
150Abnormality of homocysteine metabolism (HP:0010919)1.65218729
151Homocystinuria (HP:0002156)1.65218729
152Partial duplication of thumb phalanx (HP:0009944)1.65147925
153Pendular nystagmus (HP:0012043)1.64471652
154Molar tooth sign on MRI (HP:0002419)1.64188252
155Abnormality of midbrain morphology (HP:0002418)1.64188252
156Genital tract atresia (HP:0001827)1.63415322
157Abnormal mitochondria in muscle tissue (HP:0008316)1.63203354
158Fibular aplasia (HP:0002990)1.63150600
1592-3 toe syndactyly (HP:0004691)1.62024805
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.61709138
161Spina bifida occulta (HP:0003298)1.60786587
162Hypoplastic female external genitalia (HP:0012815)1.60562084
163Increased nuchal translucency (HP:0010880)1.60008188
164Diastasis recti (HP:0001540)1.58702880
165Micropenis (HP:0000054)1.58595865
166Lissencephaly (HP:0001339)1.58319445
167Vaginal atresia (HP:0000148)1.57869666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.09941981
2SRPK12.96412502
3WEE12.91074821
4CDC72.85741919
5PNCK2.85006546
6ICK2.78224548
7TNIK2.77813713
8DYRK32.69363154
9DYRK22.47407453
10MKNK12.36945263
11MKNK22.14847098
12VRK12.14814400
13TAF11.95993336
14MAP3K41.90871227
15MAP3K101.90395925
16PLK41.89522515
17PRPF4B1.86709159
18BRD41.83444795
19TLK11.81157577
20EPHB21.80017670
21MAP4K21.77970426
22CDK71.76499864
23AURKA1.75073078
24TAOK21.73381579
25NEK21.69807358
26CDK121.68549305
27PAK41.66131677
28TTK1.65838202
29MAP2K61.61271179
30FGFR21.54761165
31PLK11.51854619
32MARK11.51378286
33BRAF1.45064112
34EIF2AK11.44800357
35BCR1.41044876
36LATS21.39840828
37UHMK11.39306242
38AURKB1.34426035
39PLK31.33353441
40PASK1.32804499
41TESK21.29675644
42KSR11.27607880
43STK161.27388009
44NTRK21.25534995
45EPHA41.24279791
46ATR1.24085196
47BMPR1B1.21917842
48MAP3K51.11633722
49NME11.07717977
50CAMK1G1.07321273
51MAP2K71.07114883
52TRIM281.06200485
53MAP2K21.05618890
54CHEK21.05445704
55CHEK11.04025360
56EPHA21.03395938
57LIMK11.00277010
58NUAK11.00203673
59FRK1.00175693
60TSSK60.99650597
61RPS6KA40.98381932
62CSNK1E0.96855524
63CDK40.95993501
64ABL20.95663147
65LATS10.93660723
66PRKCI0.93055922
67CDK20.91007877
68BRSK20.90852721
69NME20.90738947
70CSNK1G20.87827224
71PAK10.85899889
72IRAK20.85786123
73STK38L0.85698577
74MAP3K80.83321598
75PBK0.82949581
76AKT20.80933332
77MAP3K110.79611577
78INSRR0.79021079
79MAP3K90.78653994
80PINK10.77658686
81YES10.76608423
82VRK20.75872017
83WNK30.74835324
84ATM0.74626171
85CSNK2A20.74496975
86MINK10.73220803
87CDK10.73069943
88STK40.72770380
89OXSR10.72394865
90NTRK30.71903451
91PRKCG0.68955431
92EEF2K0.68740074
93CAMK1D0.68463085
94WNK40.67515163
95SGK20.67393756
96ERBB20.67126169
97CSNK2A10.67047729
98NLK0.64215180
99OBSCN0.62382677
100CSNK1G10.61568567
101MTOR0.60307264
102GRK10.60254583
103CSNK1G30.59974453
104CSNK1A1L0.59957614
105BRSK10.59778930
106SGK4940.59738391
107SGK2230.59738391
108STK390.59574868
109ADRBK20.57449114
110CDK30.56972075
111PLK20.56295991
112STK30.55802170
113RPS6KB20.55442287
114FGFR10.55148569
115SIK20.54167438
116TGFBR10.54133231
117ERBB30.53986871
118MAPK130.53895294
119RPS6KA50.53550825
120TYRO30.51529292
121ILK0.51296068
122CDK190.50322470
123MAP2K40.47768171
124STK110.47483848
125DAPK30.46107231
126CDK11A0.42879484
127RPS6KA10.42529270
128MAPK90.41768676
129DYRK1A0.39241213
130PRKDC0.39043130
131CSNK1D0.38877684
132GSK3B0.38390495
133EIF2AK20.37857275
134STK240.37028704
135MELK0.36875792
136FLT30.36382234
137CDK180.36362944
138AKT10.35937410
139NEK10.35523421
140ZAK0.35308273
141CASK0.34726531
142ACVR1B0.33311688
143CDK150.32149479
144GSK3A0.30513964

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.42586817
2Spliceosome_Homo sapiens_hsa030403.95377026
3DNA replication_Homo sapiens_hsa030303.79661095
4Mismatch repair_Homo sapiens_hsa034303.70703468
5Homologous recombination_Homo sapiens_hsa034403.65468240
6RNA polymerase_Homo sapiens_hsa030203.63517044
7Fanconi anemia pathway_Homo sapiens_hsa034603.59995203
8Nucleotide excision repair_Homo sapiens_hsa034203.43919948
9Proteasome_Homo sapiens_hsa030503.11593819
10RNA transport_Homo sapiens_hsa030132.95594284
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87507100
12Base excision repair_Homo sapiens_hsa034102.41509456
13Pyrimidine metabolism_Homo sapiens_hsa002402.32597635
14Cell cycle_Homo sapiens_hsa041102.12816647
15mRNA surveillance pathway_Homo sapiens_hsa030152.12701872
16One carbon pool by folate_Homo sapiens_hsa006702.01885784
17RNA degradation_Homo sapiens_hsa030181.98627444
18Basal transcription factors_Homo sapiens_hsa030221.89882381
19Basal cell carcinoma_Homo sapiens_hsa052171.87389453
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81706523
21Steroid biosynthesis_Homo sapiens_hsa001001.81210289
22Huntingtons disease_Homo sapiens_hsa050161.69336180
23Parkinsons disease_Homo sapiens_hsa050121.68869827
24Oxidative phosphorylation_Homo sapiens_hsa001901.68778243
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.66368598
26Hedgehog signaling pathway_Homo sapiens_hsa043401.35869293
27Non-homologous end-joining_Homo sapiens_hsa034501.34225196
28Taste transduction_Homo sapiens_hsa047421.32815476
29Systemic lupus erythematosus_Homo sapiens_hsa053221.30702412
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30107676
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22370957
32Purine metabolism_Homo sapiens_hsa002301.20150336
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17707105
34Hippo signaling pathway_Homo sapiens_hsa043901.15127464
35Cocaine addiction_Homo sapiens_hsa050301.13888459
36* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08352946
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05411065
38Oocyte meiosis_Homo sapiens_hsa041141.03394390
39Notch signaling pathway_Homo sapiens_hsa043301.01941789
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96791567
41GABAergic synapse_Homo sapiens_hsa047270.95584331
42Propanoate metabolism_Homo sapiens_hsa006400.91615351
43Butanoate metabolism_Homo sapiens_hsa006500.90445793
44Epstein-Barr virus infection_Homo sapiens_hsa051690.89373133
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89279669
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.89103928
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88564342
48Glutamatergic synapse_Homo sapiens_hsa047240.88489527
49Cardiac muscle contraction_Homo sapiens_hsa042600.88184668
50Alzheimers disease_Homo sapiens_hsa050100.87300650
51Sulfur relay system_Homo sapiens_hsa041220.86138257
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85530685
53Olfactory transduction_Homo sapiens_hsa047400.85387130
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80677076
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79031991
56Morphine addiction_Homo sapiens_hsa050320.78895579
57Circadian entrainment_Homo sapiens_hsa047130.78095642
58p53 signaling pathway_Homo sapiens_hsa041150.77912985
59Dopaminergic synapse_Homo sapiens_hsa047280.77196226
60Wnt signaling pathway_Homo sapiens_hsa043100.75764887
61Alcoholism_Homo sapiens_hsa050340.75292075
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74808485
63MicroRNAs in cancer_Homo sapiens_hsa052060.72548407
64Biosynthesis of amino acids_Homo sapiens_hsa012300.71060170
65Folate biosynthesis_Homo sapiens_hsa007900.68453928
66Thyroid cancer_Homo sapiens_hsa052160.65311660
67Tight junction_Homo sapiens_hsa045300.64867874
68Phototransduction_Homo sapiens_hsa047440.63073586
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62564192
70Amphetamine addiction_Homo sapiens_hsa050310.61012682
71Vitamin B6 metabolism_Homo sapiens_hsa007500.59624923
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57992952
73Serotonergic synapse_Homo sapiens_hsa047260.56637514
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55888129
75Glutathione metabolism_Homo sapiens_hsa004800.55095327
76Nitrogen metabolism_Homo sapiens_hsa009100.54125786
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54033651
78Axon guidance_Homo sapiens_hsa043600.53704375
79Arginine and proline metabolism_Homo sapiens_hsa003300.52477480
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51707432
81Retinol metabolism_Homo sapiens_hsa008300.48888759
82Long-term depression_Homo sapiens_hsa047300.48585652
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48503694
84Arachidonic acid metabolism_Homo sapiens_hsa005900.48144226
85Insulin secretion_Homo sapiens_hsa049110.47050331
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.46313612
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.46301710
88Vitamin digestion and absorption_Homo sapiens_hsa049770.46165949
89Tyrosine metabolism_Homo sapiens_hsa003500.46104209
90Circadian rhythm_Homo sapiens_hsa047100.45851386
91* TGF-beta signaling pathway_Homo sapiens_hsa043500.44473751
92cAMP signaling pathway_Homo sapiens_hsa040240.43583400
93Pyruvate metabolism_Homo sapiens_hsa006200.43143682
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.42831881
95Lysine degradation_Homo sapiens_hsa003100.42593041
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42148246
97Pathways in cancer_Homo sapiens_hsa052000.40956426
98Melanogenesis_Homo sapiens_hsa049160.40835252
99Cholinergic synapse_Homo sapiens_hsa047250.40444369
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40298197
101Dilated cardiomyopathy_Homo sapiens_hsa054140.38898084
102Protein export_Homo sapiens_hsa030600.35369428
103HTLV-I infection_Homo sapiens_hsa051660.35281754
104Linoleic acid metabolism_Homo sapiens_hsa005910.34444003
105Metabolic pathways_Homo sapiens_hsa011000.34338817
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32793193
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32443233
108Phenylalanine metabolism_Homo sapiens_hsa003600.32347797
109Viral carcinogenesis_Homo sapiens_hsa052030.32082024
110Adherens junction_Homo sapiens_hsa045200.30929273
111Colorectal cancer_Homo sapiens_hsa052100.29347777
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29181682
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.27432454
114Melanoma_Homo sapiens_hsa052180.27402594
115Nicotine addiction_Homo sapiens_hsa050330.26108578
116Endometrial cancer_Homo sapiens_hsa052130.23182805
117Herpes simplex infection_Homo sapiens_hsa051680.20931731
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.19733322
119Fructose and mannose metabolism_Homo sapiens_hsa000510.18694659
120Gap junction_Homo sapiens_hsa045400.18158111
121Bladder cancer_Homo sapiens_hsa052190.17244228
122Prion diseases_Homo sapiens_hsa050200.17053259
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15264848
124Carbon metabolism_Homo sapiens_hsa012000.13903860
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13116453
126Prostate cancer_Homo sapiens_hsa052150.11936299
127Renal cell carcinoma_Homo sapiens_hsa052110.10452549
128Selenocompound metabolism_Homo sapiens_hsa004500.09561750
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.08502346
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07761050
131Small cell lung cancer_Homo sapiens_hsa052220.05707497
132Fat digestion and absorption_Homo sapiens_hsa049750.05671137
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04989951
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.04044465
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03150158
136Rap1 signaling pathway_Homo sapiens_hsa040150.02830559
137Proteoglycans in cancer_Homo sapiens_hsa052050.01866559

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