ACVRL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)7.91071617
2chemical homeostasis within a tissue (GO:0048875)6.17730708
3positive regulation of vasculogenesis (GO:2001214)5.82224780
4regulation of vasculogenesis (GO:2001212)5.76007098
5lymph vessel development (GO:0001945)5.73457624
6vascular endothelial growth factor signaling pathway (GO:0038084)5.70323170
7cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.99289981
8* regulation of endothelial cell differentiation (GO:0045601)4.86487337
9retina vasculature morphogenesis in camera-type eye (GO:0061299)4.77817280
10endothelium development (GO:0003158)4.51477000
11* negative regulation of blood vessel endothelial cell migration (GO:0043537)4.43829592
12angiogenesis involved in wound healing (GO:0060055)4.14299027
13basement membrane organization (GO:0071711)4.09628714
14endothelial cell morphogenesis (GO:0001886)4.01880281
15renal filtration (GO:0097205)3.90365571
16glomerular filtration (GO:0003094)3.73826557
17cellular response to nitric oxide (GO:0071732)3.70586836
18venous blood vessel morphogenesis (GO:0048845)3.63960344
19* positive regulation of endothelial cell differentiation (GO:0045603)3.62462241
20lung lobe morphogenesis (GO:0060463)3.51439650
21* negative regulation of endothelial cell migration (GO:0010596)3.51311810
22lung vasculature development (GO:0060426)3.48289200
23* blood vessel maturation (GO:0001955)3.43362303
24cell migration involved in sprouting angiogenesis (GO:0002042)3.42998696
25vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.41066690
26positive regulation of p38MAPK cascade (GO:1900745)3.41013651
27Notch signaling involved in heart development (GO:0061314)3.39932738
28* morphogenesis of an endothelium (GO:0003159)3.39582092
29* endothelial tube morphogenesis (GO:0061154)3.39582092
30patterning of blood vessels (GO:0001569)3.38148638
31positive regulation of receptor recycling (GO:0001921)3.37883214
32apoptotic cell clearance (GO:0043277)3.36519447
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.34802647
34axon extension involved in axon guidance (GO:0048846)3.34802647
35cell migration involved in heart development (GO:0060973)3.33792647
36endocrine process (GO:0050886)3.31922805
37regulation of systemic arterial blood pressure by hormone (GO:0001990)3.31922805
38regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.31922805
39vasculogenesis (GO:0001570)3.26907281
40* endothelial cell differentiation (GO:0045446)3.26377669
41cell adhesion mediated by integrin (GO:0033627)3.26046886
42endothelial cell chemotaxis (GO:0035767)3.25767601
43substrate-dependent cell migration (GO:0006929)3.22981538
44blood vessel endothelial cell migration (GO:0043534)3.21274304
45hyaluronan catabolic process (GO:0030214)3.20145910
46low-density lipoprotein particle clearance (GO:0034383)3.16790934
47regulation of p38MAPK cascade (GO:1900744)3.15675373
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.13531311
49* lymphangiogenesis (GO:0001946)3.12620544
50respiratory tube development (GO:0030323)3.11947504
51* regulation of blood vessel endothelial cell migration (GO:0043535)3.11651155
52establishment of endothelial barrier (GO:0061028)3.09733069
53* blood vessel remodeling (GO:0001974)3.08686910
54stress fiber assembly (GO:0043149)3.08510378
55protein localization to endosome (GO:0036010)3.06040453
56positive regulation of urine volume (GO:0035810)3.04181083
57* wound healing, spreading of epidermal cells (GO:0035313)3.03904042
58cAMP biosynthetic process (GO:0006171)3.02412535
59positive regulation of macrophage cytokine production (GO:0060907)3.02099547
60cellular response to reactive nitrogen species (GO:1902170)3.01560415
61negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.01253219
62neuron remodeling (GO:0016322)3.00487904
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.00415310
64adhesion of symbiont to host (GO:0044406)2.96609592
65endodermal cell differentiation (GO:0035987)2.95266070
66sprouting angiogenesis (GO:0002040)2.94241133
67* angiogenesis (GO:0001525)2.94190215
68positive regulation of endothelial cell apoptotic process (GO:2000353)2.93466030
69mesodermal cell differentiation (GO:0048333)2.91423462
70regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88619349
71adhesion of symbiont to host cell (GO:0044650)2.88377529
72virion attachment to host cell (GO:0019062)2.88377529
73negative regulation of angiogenesis (GO:0016525)2.88338641
74positive regulation of endothelial cell migration (GO:0010595)2.88231142
75negative regulation of vascular permeability (GO:0043116)2.87889103
76* regulation of endothelial cell migration (GO:0010594)2.87091122
77response to nitric oxide (GO:0071731)2.86145000
78response to xenobiotic stimulus (GO:0009410)2.85501823
79renal system process involved in regulation of blood volume (GO:0001977)2.83150763
80toxin metabolic process (GO:0009404)2.82080634
81negative regulation of nitric-oxide synthase activity (GO:0051001)2.81470827
82negative regulation of platelet activation (GO:0010544)2.80042208
83negative regulation of blood vessel morphogenesis (GO:2000181)2.78417527
84coronary vasculature morphogenesis (GO:0060977)2.75865698
85regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.74747113
86negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.74743579
87antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72161825
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72161825
89negative regulation of endothelial cell apoptotic process (GO:2000352)2.68440701
90regulation of systemic arterial blood pressure (GO:0003073)2.68428864
91regulation of transforming growth factor beta1 production (GO:0032908)2.67965520
92regulation of cholesterol storage (GO:0010885)2.67447937
93transcytosis (GO:0045056)2.65837973
94ovulation from ovarian follicle (GO:0001542)2.63995966
95regulation of integrin-mediated signaling pathway (GO:2001044)2.63753569
96peptide catabolic process (GO:0043171)2.63440640
97negative regulation of vasculature development (GO:1901343)2.63292257
98positive regulation of cell junction assembly (GO:1901890)2.62652297
99positive regulation of focal adhesion assembly (GO:0051894)2.62652297
100heart trabecula formation (GO:0060347)2.62013937
101nephron epithelium development (GO:0072009)2.59780560
102embryonic heart tube development (GO:0035050)2.59401509
103* negative regulation of epithelial cell migration (GO:0010633)2.58934746
104embryonic foregut morphogenesis (GO:0048617)2.57507884
105positive regulation of epithelial cell migration (GO:0010634)2.57364439
106membrane raft organization (GO:0031579)2.56095643
107positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56067696
108positive regulation of odontogenesis (GO:0042482)2.55852029
109response to laminar fluid shear stress (GO:0034616)2.55668085
110negative regulation of anoikis (GO:2000811)2.55343345
111regulation of establishment or maintenance of cell polarity (GO:0032878)2.54685457
112glomerular visceral epithelial cell development (GO:0072015)2.53259913
113regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.53248563
114positive regulation of adherens junction organization (GO:1903393)2.52078097
115positive regulation of pseudopodium assembly (GO:0031274)2.51081875
116regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.50627881
117glomerular epithelial cell development (GO:0072310)2.49725508
118barbed-end actin filament capping (GO:0051016)2.49479468
119negative regulation of mast cell activation (GO:0033004)2.49336663
120regulation of macrophage chemotaxis (GO:0010758)2.48379572
121substrate adhesion-dependent cell spreading (GO:0034446)2.48214136
122regulation of glomerular filtration (GO:0003093)2.48070597
123semaphorin-plexin signaling pathway (GO:0071526)2.47804547
124antigen processing and presentation of endogenous antigen (GO:0019883)2.47713431
125arginine catabolic process (GO:0006527)2.46989340
126positive regulation of lipid kinase activity (GO:0090218)2.46816065
127endothelial cell migration (GO:0043542)2.46659880
128glomerular basement membrane development (GO:0032836)2.46375910
129hormone catabolic process (GO:0042447)2.45974956
130negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.45624146
131* regulation of epithelial cell migration (GO:0010632)2.44985412
132negative regulation of fatty acid transport (GO:2000192)2.42603895
133ganglion development (GO:0061548)2.41985671
134regulation of pseudopodium assembly (GO:0031272)2.41845549
135establishment of apical/basal cell polarity (GO:0035089)2.40487513
136negative regulation of Rho protein signal transduction (GO:0035024)2.40051162
137growth hormone receptor signaling pathway (GO:0060396)2.39749507
138regulation of vascular permeability (GO:0043114)2.39719948
139negative regulation of chondrocyte differentiation (GO:0032331)2.39326744
140phagocytosis, recognition (GO:0006910)2.39138293
141cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.38328436
142protein kinase C signaling (GO:0070528)2.38114252
143negative regulation of protein autophosphorylation (GO:0031953)2.38100000
144endocardial cushion development (GO:0003197)2.37015601
145chondrocyte proliferation (GO:0035988)2.36290047
146trabecula morphogenesis (GO:0061383)2.36260698
147regulation of macrophage cytokine production (GO:0010935)2.36168481
148regulation of endothelial cell apoptotic process (GO:2000351)2.35918156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.76746575
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.81019466
3GATA1_22025678_ChIP-Seq_K562_Human3.65353212
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.27745852
5CLOCK_20551151_ChIP-Seq_293T_Human3.22625850
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97990065
7* GATA2_21666600_ChIP-Seq_HMVEC_Human2.97036433
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.56853367
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43969577
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25474665
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25029361
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.13187568
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.11349442
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07995617
15* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.06036685
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.05754936
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84302904
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81526936
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79547190
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.77673729
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71625034
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68511574
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67169178
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.66958874
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61334892
26* TBX20_22328084_ChIP-Seq_HEART_Mouse1.59062400
27* TBX20_22080862_ChIP-Seq_HEART_Mouse1.59062400
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58362332
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.57735221
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55927766
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53889582
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52107989
33CJUN_26792858_Chip-Seq_BT549_Human1.52036447
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.49716605
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.48928720
36* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43169178
37* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43169178
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43046914
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40987513
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39505212
41* GATA1_19941826_ChIP-Seq_K562_Human1.38984599
42SOX2_20726797_ChIP-Seq_SW620_Human1.37616174
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36965238
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.36152808
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.35856750
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35771404
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35051841
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34878014
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34322852
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.33084959
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31853191
52LXR_22292898_ChIP-Seq_THP-1_Human1.31059404
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29034144
54SPI1_23127762_ChIP-Seq_K562_Human1.28601506
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27794971
56RACK7_27058665_Chip-Seq_MCF-7_Human1.27350482
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27033617
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26866540
59* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26742475
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22375078
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21491989
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21267994
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19888940
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.18386297
65RUNX_20019798_ChIP-Seq_JUKART_Human1.17999005
66DROSHA_22980978_ChIP-Seq_HELA_Human1.17582999
67KDM2B_26808549_Chip-Seq_DND41_Human1.16938936
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16901090
69KDM2B_26808549_Chip-Seq_K562_Human1.16805132
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16511800
71* LXR_22158963_ChIP-Seq_LIVER_Mouse1.15241003
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14330593
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14330593
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.13870528
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13075748
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13038454
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12861523
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12583457
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12075728
80AHR_22903824_ChIP-Seq_MCF-7_Human1.11372555
81* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09023663
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07598266
83SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07097856
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06809015
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05978795
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05471416
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03939717
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03912589
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03070464
90* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02963479
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02933063
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02734262
93* BRD4_25478319_ChIP-Seq_HGPS_Human1.00151746
94P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99088906
95ZNF263_19887448_ChIP-Seq_K562_Human0.98726656
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98171511
97* GATA2_19941826_ChIP-Seq_K562_Human0.97652724
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97617097
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96383409
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95769301
101MAF_26560356_Chip-Seq_TH1_Human0.95422220
102NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94683515
103RXR_22158963_ChIP-Seq_LIVER_Mouse0.93224594
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93173304
105* EZH2_27294783_Chip-Seq_ESCs_Mouse0.93042559
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92616816
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92109066
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91428358
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90965117
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90662281
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89934866
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.89580808
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88946884
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.88607338
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.88591217
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88561617
117TCF7_22412390_ChIP-Seq_EML_Mouse0.88084395
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87042347
119* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86935417
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86888480
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86888480
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.86437226
123BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85853719
124VDR_24787735_ChIP-Seq_THP-1_Human0.85288900
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85005240
126PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84644030
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84553308
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84447407
129RNF2_27304074_Chip-Seq_ESCs_Mouse0.83675866
130SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82897149
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.81625702
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81103385
133GATA4_25053715_ChIP-Seq_YYC3_Human0.80119275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.24841116
2MP0005167_abnormal_blood-brain_barrier5.14664498
3MP0001879_abnormal_lymphatic_vessel5.01860296
4MP0001958_emphysema4.01166666
5MP0004272_abnormal_basement_membrane3.59896912
6MP0003724_increased_susceptibility_to3.53594355
7MP0004782_abnormal_surfactant_physiolog3.02899295
8MP0008438_abnormal_cutaneous_collagen2.94243542
9MP0003828_pulmonary_edema2.54538245
10MP0003705_abnormal_hypodermis_morpholog2.47650113
11MP0003191_abnormal_cellular_cholesterol2.42025293
12MP0003566_abnormal_cell_adhesion2.32523497
13MP0003303_peritoneal_inflammation2.24739189
14MP0004084_abnormal_cardiac_muscle2.21430059
15MP0000343_altered_response_to2.19152644
16MP0003279_aneurysm2.08978285
17MP0005275_abnormal_skin_tensile2.04782125
18MP0006054_spinal_hemorrhage1.86940490
19MP0005409_darkened_coat_color1.85116515
20MP0006138_congestive_heart_failure1.84633755
21* MP0000767_abnormal_smooth_muscle1.82875767
22MP0002295_abnormal_pulmonary_circulatio1.76769807
23MP0000249_abnormal_blood_vessel1.75940472
24MP0005164_abnormal_response_to1.66712059
25MP0004510_myositis1.64834884
26MP0002933_joint_inflammation1.62924136
27MP0003300_gastrointestinal_ulcer1.61692839
28MP0009278_abnormal_bone_marrow1.56650477
29MP0004883_abnormal_blood_vessel1.54248553
30MP0005165_increased_susceptibility_to1.53408166
31MP0005388_respiratory_system_phenotype1.50719641
32MP0002133_abnormal_respiratory_system1.50719641
33MP0003091_abnormal_cell_migration1.49748909
34MP0001544_abnormal_cardiovascular_syste1.45325183
35MP0005385_cardiovascular_system_phenoty1.45325183
36* MP0000465_gastrointestinal_hemorrhage1.43323546
37MP0003075_altered_response_to1.38608200
38MP0002877_abnormal_melanocyte_morpholog1.32885559
39MP0002332_abnormal_exercise_endurance1.31938613
40MP0004036_abnormal_muscle_relaxation1.30613295
41MP0010030_abnormal_orbit_morphology1.27121619
42MP0005023_abnormal_wound_healing1.22371361
43* MP0005595_abnormal_vascular_smooth1.22144519
44MP0003950_abnormal_plasma_membrane1.20088843
45* MP0002128_abnormal_blood_circulation1.16116803
46MP0009764_decreased_sensitivity_to1.13626448
47MP0000013_abnormal_adipose_tissue1.12516428
48* MP0002925_abnormal_cardiovascular_devel1.12296325
49MP0001533_abnormal_skeleton_physiology1.11224810
50MP0003045_fibrosis1.10783796
51* MP0001614_abnormal_blood_vessel1.08779030
52MP0008775_abnormal_heart_ventricle1.08728793
53MP0009840_abnormal_foam_cell1.06074967
54MP0000751_myopathy1.06066809
55MP0004145_abnormal_muscle_electrophysio1.05544414
56MP0003868_abnormal_feces_composition1.05039034
57MP0001851_eye_inflammation1.04982279
58MP0001545_abnormal_hematopoietic_system1.04121778
59MP0005397_hematopoietic_system_phenotyp1.04121778
60MP0002896_abnormal_bone_mineralization1.03952922
61MP0009785_altered_susceptibility_to1.03351835
62MP0003448_altered_tumor_morphology1.02874555
63MP0005670_abnormal_white_adipose1.02600130
64MP0008995_early_reproductive_senescence1.01879256
65MP0004484_altered_response_of1.00769451
66MP0005257_abnormal_intraocular_pressure0.99215408
67MP0002972_abnormal_cardiac_muscle0.98887374
68MP0001849_ear_inflammation0.97362232
69MP0005058_abnormal_lysosome_morphology0.96432599
70MP0010630_abnormal_cardiac_muscle0.94857447
71MP0005166_decreased_susceptibility_to0.94548822
72MP0002132_abnormal_respiratory_system0.93976309
73MP0005360_urolithiasis0.93916728
74MP0004130_abnormal_muscle_cell0.93221821
75MP0001915_intracranial_hemorrhage0.93123326
76* MP0001175_abnormal_lung_morphology0.90072509
77MP0005503_abnormal_tendon_morphology0.89642820
78MP0005330_cardiomyopathy0.88008254
79MP0000003_abnormal_adipose_tissue0.87519792
80MP0005623_abnormal_meninges_morphology0.87289302
81MP0002108_abnormal_muscle_morphology0.86918685
82MP0008004_abnormal_stomach_pH0.83293444
83MP0002127_abnormal_cardiovascular_syste0.82968627
84MP0004085_abnormal_heartbeat0.82242645
85MP0002166_altered_tumor_susceptibility0.81452527
86MP0003436_decreased_susceptibility_to0.80950715
87MP0008875_abnormal_xenobiotic_pharmacok0.80839834
88MP0002419_abnormal_innate_immunity0.79233933
89MP0002998_abnormal_bone_remodeling0.79162358
90MP0004858_abnormal_nervous_system0.78445650
91MP0004215_abnormal_myocardial_fiber0.78135873
92MP0000230_abnormal_systemic_arterial0.76723641
93MP0005508_abnormal_skeleton_morphology0.75910458
94MP0000750_abnormal_muscle_regeneration0.75270610
95MP0001790_abnormal_immune_system0.74483237
96MP0005387_immune_system_phenotype0.74483237
97MP0009780_abnormal_chondrocyte_physiolo0.73589955
98MP0004087_abnormal_muscle_fiber0.71368365
99MP0005464_abnormal_platelet_physiology0.70996675
100* MP0000266_abnormal_heart_morphology0.70176651
101MP0005025_abnormal_response_to0.69140142
102MP0004233_abnormal_muscle_weight0.69013233
103MP0003283_abnormal_digestive_organ0.67878104
104MP0005620_abnormal_muscle_contractility0.66644929
105MP0002837_dystrophic_cardiac_calcinosis0.66223284
106MP0001663_abnormal_digestive_system0.66198147
107MP0001835_abnormal_antigen_presentation0.65484848
108MP0001756_abnormal_urination0.65445836
109MP0000749_muscle_degeneration0.64587497
110MP0010234_abnormal_vibrissa_follicle0.64516557
111MP0002277_abnormal_respiratory_mucosa0.64404865
112MP0002168_other_aberrant_phenotype0.64390499
113MP0003941_abnormal_skin_development0.64086720
114MP0005375_adipose_tissue_phenotype0.63079891
115MP0005084_abnormal_gallbladder_morpholo0.62646728
116MP0009384_cardiac_valve_regurgitation0.62175756
117MP0001784_abnormal_fluid_regulation0.61668352
118MP0002405_respiratory_system_inflammati0.59910579
119MP0010155_abnormal_intestine_physiology0.59478761
120MP0000685_abnormal_immune_system0.59379058
121MP0001542_abnormal_bone_strength0.59275614
122MP0000467_abnormal_esophagus_morphology0.58847733
123MP0005390_skeleton_phenotype0.58106094
124MP0002136_abnormal_kidney_physiology0.57933960
125MP0001177_atelectasis0.57437393
126MP0000759_abnormal_skeletal_muscle0.56193459
127MP0010352_gastrointestinal_tract_polyps0.53919612

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)5.62102720
2* Polycythemia (HP:0001901)4.95472801
3Cerebral aneurysm (HP:0004944)4.59122766
4Hyperactive renin-angiotensin system (HP:0000841)4.19952964
5Broad metatarsal (HP:0001783)3.86299816
6* Hematochezia (HP:0002573)3.64942938
7Eczematoid dermatitis (HP:0000976)3.63620811
8* Spontaneous hematomas (HP:0007420)3.60878684
9Aortic aneurysm (HP:0004942)3.48692960
10Pulmonary artery stenosis (HP:0004415)3.20459160
11Cervical subluxation (HP:0003308)3.09013423
12Deep venous thrombosis (HP:0002625)3.06004275
13* Abnormality of the nasal mucosa (HP:0000433)3.04592840
14* Esophageal varix (HP:0002040)2.99751520
15Skull defect (HP:0001362)2.98383239
16Increased connective tissue (HP:0009025)2.97513422
17Aortic dissection (HP:0002647)2.95784291
18Vascular tortuosity (HP:0004948)2.83279343
19Long toe (HP:0010511)2.82641072
20Aneurysm (HP:0002617)2.81990675
21Growth hormone excess (HP:0000845)2.81470566
22Premature rupture of membranes (HP:0001788)2.79896340
23Overgrowth (HP:0001548)2.78172593
24Protrusio acetabuli (HP:0003179)2.77664745
25Chronic bronchitis (HP:0004469)2.77513499
26Camptodactyly of toe (HP:0001836)2.77228721
27Hip contracture (HP:0003273)2.76110710
28Type 1 muscle fiber predominance (HP:0003803)2.74613973
29Recurrent gram-negative bacterial infections (HP:0005420)2.72093430
30Distal lower limb muscle weakness (HP:0009053)2.70488727
31Increased variability in muscle fiber diameter (HP:0003557)2.69932515
32Arterial tortuosity (HP:0005116)2.64133339
33Facial shape deformation (HP:0011334)2.63323975
34Potter facies (HP:0002009)2.63323975
35Wormian bones (HP:0002645)2.62484302
36Right ventricular cardiomyopathy (HP:0011663)2.62320426
37Nonimmune hydrops fetalis (HP:0001790)2.60545439
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.60076608
39Osteolytic defects of the hand bones (HP:0009699)2.60076608
40Lymphangioma (HP:0100764)2.58797422
41Hyperkalemia (HP:0002153)2.57879144
42Tetraparesis (HP:0002273)2.54601424
43Spinal rigidity (HP:0003306)2.53891554
44Abnormality of skeletal muscle fiber size (HP:0012084)2.50866475
45Mitral valve prolapse (HP:0001634)2.49322787
46Shallow orbits (HP:0000586)2.46798484
47Muscle fiber splitting (HP:0003555)2.46203321
48Myotonia (HP:0002486)2.45708685
49Ankle contracture (HP:0006466)2.45057306
50* Pulmonary hypertension (HP:0002092)2.44868726
51Amyloidosis (HP:0011034)2.43854116
52Blue sclerae (HP:0000592)2.42037655
53Absent hand (HP:0004050)2.41187953
54Systemic lupus erythematosus (HP:0002725)2.40427945
55Abnormal vertebral ossification (HP:0100569)2.38395468
56Hydroureter (HP:0000072)2.36497572
57Complement deficiency (HP:0004431)2.32433378
58Ventricular tachycardia (HP:0004756)2.31888322
59Renal salt wasting (HP:0000127)2.30071433
60Disproportionate tall stature (HP:0001519)2.30061210
61Limited hip movement (HP:0008800)2.29721732
62Difficulty climbing stairs (HP:0003551)2.29300111
63Wrist flexion contracture (HP:0001239)2.28745649
64Nephritis (HP:0000123)2.27767581
65Single umbilical artery (HP:0001195)2.26231035
66Abnormality of the fetal cardiovascular system (HP:0010948)2.26231035
67Abnormal umbilical cord blood vessels (HP:0011403)2.26231035
68Joint stiffness (HP:0001387)2.23216064
69Distal lower limb amyotrophy (HP:0008944)2.23207333
70Joint contractures involving the joints of the feet (HP:0100492)2.22677642
71Flexion contracture of toe (HP:0005830)2.22677642
72Bladder diverticulum (HP:0000015)2.22202687
73Hyporeflexia of lower limbs (HP:0002600)2.20019415
74Annular pancreas (HP:0001734)2.19383911
75Sudden death (HP:0001699)2.15278068
76Flat acetabular roof (HP:0003180)2.14569295
77Porencephaly (HP:0002132)2.12050917
78Aortic valve stenosis (HP:0001650)2.11432643
79Ectopia lentis (HP:0001083)2.09734389
80Soft skin (HP:0000977)2.06837820
81Striae distensae (HP:0001065)2.06754577
82Coxa vara (HP:0002812)2.05465161
83Hemorrhage of the eye (HP:0011885)2.04922932
84Vertebral clefting (HP:0008428)2.04421045
85Vertebral compression fractures (HP:0002953)2.03806039
86Rectal prolapse (HP:0002035)2.03407141
87Atrophic scars (HP:0001075)2.03337515
88Broad face (HP:0000283)2.03217627
89Reduced subcutaneous adipose tissue (HP:0003758)2.00225550
90* Visceral angiomatosis (HP:0100761)2.00140446
91Urinary glycosaminoglycan excretion (HP:0003541)1.99892776
92Mucopolysacchariduria (HP:0008155)1.99892776
93Abnormality of the acetabulum (HP:0003170)1.98936370
94Venous abnormality (HP:0002624)1.98860389
95Joint laxity (HP:0001388)1.97705098
96Hypoplasia of the iris (HP:0007676)1.97440124
97Mesangial abnormality (HP:0001966)1.96906214
98Abnormality of polysaccharide metabolism (HP:0011012)1.95993642
99Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95993642
100Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95993642
101Tubulointerstitial fibrosis (HP:0005576)1.93271329
102Menorrhagia (HP:0000132)1.92993076
103Round ear (HP:0100830)1.92459126
104Mitral stenosis (HP:0001718)1.92382839
105Adactyly (HP:0009776)1.92268681
106Dysostosis multiplex (HP:0000943)1.92050238
107Tachypnea (HP:0002789)1.91684704
108Neonatal death (HP:0003811)1.91439300
109Venous insufficiency (HP:0005293)1.90566740
110Chondrocalcinosis (HP:0000934)1.89248545
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.89196532
112Difficulty running (HP:0009046)1.88981954
113Dilatation of the ascending aorta (HP:0005111)1.88629000
114Increased cerebral lipofuscin (HP:0011813)1.88468426
115Hyperaldosteronism (HP:0000859)1.87728208
116* Hemangiomatosis (HP:0007461)1.86661443
117Abnormality of glycolipid metabolism (HP:0010969)1.85623556
118Abnormality of liposaccharide metabolism (HP:0010968)1.85623556
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.85623556
120Asymmetric septal hypertrophy (HP:0001670)1.85359405
121Pigmentary retinal degeneration (HP:0001146)1.84872476
122Subacute progressive viral hepatitis (HP:0006572)1.84238359
123Rapidly progressive (HP:0003678)1.84143778
124Ulnar bowing (HP:0003031)1.83503943
125Myocardial infarction (HP:0001658)1.83254333
126Short 4th metacarpal (HP:0010044)1.82990148
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82990148
128Acanthosis nigricans (HP:0000956)1.82432134
129* Portal hypertension (HP:0001409)1.82253248
130Neonatal short-limb short stature (HP:0008921)1.82143647
131Recurrent abscess formation (HP:0002722)1.81517761
132Peritonitis (HP:0002586)1.80990006
133Decreased circulating renin level (HP:0003351)1.80920928
134Facial diplegia (HP:0001349)1.79987394
135Hypotension (HP:0002615)1.79854088
136Bronchitis (HP:0012387)1.78465767
137Asymmetry of the thorax (HP:0001555)1.77979204
138Abnormality of complement system (HP:0005339)1.77760801
139Cardiovascular calcification (HP:0011915)1.77433370
140J-shaped sella turcica (HP:0002680)1.77341111
141Follicular hyperkeratosis (HP:0007502)1.76013073
142Fragile skin (HP:0001030)1.75818263
143Abnormality of renin-angiotensin system (HP:0000847)1.74931091
144Ovoid vertebral bodies (HP:0003300)1.74785081
145Autoimmune thrombocytopenia (HP:0001973)1.74457614
146Mildly elevated creatine phosphokinase (HP:0008180)1.74250064
147Bone cyst (HP:0012062)1.73749090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.48580888
2TGFBR24.71969050
3KDR4.32516814
4RIPK12.79206723
5ERN12.67972666
6TRIB32.41442246
7EPHB12.06922597
8TGFBR12.01907387
9EPHB21.98546923
10TTN1.95259695
11GRK11.86786931
12CSK1.78396067
13MYLK1.77417051
14FGFR41.69247161
15PTK61.58763850
16LRRK21.55373748
17PTK2B1.54834688
18PDGFRA1.53755997
19PAK41.49262844
20FER1.48428968
21PKN21.34801105
22STK101.31993273
23NTRK11.30300038
24MAP2K31.24631260
25DMPK1.18876284
26TBK11.11525569
27EPHA31.03613193
28MAP3K31.02007552
29TYK20.99696647
30FGFR30.97158963
31EPHA20.94993018
32PRKG20.93504805
33PTK20.92154578
34ZAP700.91991983
35INSRR0.88940031
36PRKD10.87823818
37FGFR20.85888057
38JAK10.84483447
39MAPKAPK30.84391099
40TEC0.84217589
41PRKCH0.83217408
42PDGFRB0.82136293
43TESK10.81483585
44MAP4K10.80112144
45CDC42BPA0.78095830
46BLK0.77465502
47RPS6KA20.77134872
48DAPK20.74993308
49KIT0.73328446
50FGR0.73224676
51MAPK70.66853987
52LATS20.65930553
53PIK3CA0.65908854
54EEF2K0.65721531
55LMTK20.63920300
56MAP3K10.63918420
57FES0.63415557
58ABL20.62049499
59PDPK10.61397474
60ILK0.61161038
61IKBKE0.60970382
62MAP3K60.59870145
63DDR20.59862873
64EGFR0.58633746
65ITK0.57864220
66JAK30.57531015
67CAMK1D0.56751643
68MARK30.55961506
69JAK20.55112734
70NEK90.53445789
71MARK20.51806091
72PDK20.51223101
73RET0.50675074
74IRAK30.50615437
75MAPK120.50032390
76ACVR1B0.49106261
77GSK3A0.48775454
78HCK0.48718157
79FLT30.47076218
80MET0.46180172
81KSR20.45768769
82PRKD30.45132841
83MAP3K110.44961199
84GRK70.44893837
85SRC0.44745728
86MATK0.44186326
87MAP3K140.42305285
88LIMK10.42214558
89OBSCN0.41137144
90BMX0.40748784
91MST1R0.40556317
92PIK3CG0.40339696
93NLK0.39669704
94MAP3K20.38491958
95ROCK10.36882971
96IGF1R0.36821671
97DAPK30.36096000
98MAP3K70.34809031
99PAK20.34175029
100MAP2K20.34025439
101CAMK1G0.33255152
102FYN0.32711916
103GRK50.32419143
104MAPK150.32064593
105IRAK10.31707607
106INSR0.30861390
107STK240.30771456
108TYRO30.30505978
109TRPM70.29462512
110PRKD20.29268531
111MOS0.28839405
112ABL10.28276629
113ERBB40.27565762
114RPS6KC10.27314298
115RPS6KL10.27314298
116PHKG10.26980527
117PHKG20.26980527
118MAP2K10.25507100
119RIPK40.25316272
120PRKAA20.24870683
121MAPK40.24112042
122FGFR10.24027436
123ROCK20.23937457
124STK390.23819205
125LATS10.23446608
126CAMK40.22845959
127ADRBK10.22762605
128RPS6KA60.22688430
129PRPF4B0.21351442
130SIK10.21112791
131AKT30.20215419

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.46930846
2Leukocyte transendothelial migration_Homo sapiens_hsa046702.31744684
3AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.23132211
4Focal adhesion_Homo sapiens_hsa045102.22372073
5Adherens junction_Homo sapiens_hsa045201.87807502
6Staphylococcus aureus infection_Homo sapiens_hsa051501.87349551
7Sulfur metabolism_Homo sapiens_hsa009201.77638856
8Malaria_Homo sapiens_hsa051441.74044704
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69537474
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64416095
11Caffeine metabolism_Homo sapiens_hsa002321.62345635
12Dilated cardiomyopathy_Homo sapiens_hsa054141.62095095
13Pertussis_Homo sapiens_hsa051331.56826526
14Amoebiasis_Homo sapiens_hsa051461.56460743
15Complement and coagulation cascades_Homo sapiens_hsa046101.54005560
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53309764
17Platelet activation_Homo sapiens_hsa046111.48960295
18Leishmaniasis_Homo sapiens_hsa051401.46498231
19Viral myocarditis_Homo sapiens_hsa054161.44072426
20Toxoplasmosis_Homo sapiens_hsa051451.43330353
21Rap1 signaling pathway_Homo sapiens_hsa040151.39768390
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37470062
23Osteoclast differentiation_Homo sapiens_hsa043801.31722919
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31383020
25Proteoglycans in cancer_Homo sapiens_hsa052051.30545027
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30147281
27Small cell lung cancer_Homo sapiens_hsa052221.29343453
28Arginine biosynthesis_Homo sapiens_hsa002201.26599278
29Lysosome_Homo sapiens_hsa041421.25821165
30Salmonella infection_Homo sapiens_hsa051321.22254121
31Dorso-ventral axis formation_Homo sapiens_hsa043201.21797916
32Renin secretion_Homo sapiens_hsa049241.20555298
33VEGF signaling pathway_Homo sapiens_hsa043701.20508069
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19615849
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16671168
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14674255
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.14563964
38Tight junction_Homo sapiens_hsa045301.10038729
39Phagosome_Homo sapiens_hsa041451.09630656
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.08208339
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08040123
42Renal cell carcinoma_Homo sapiens_hsa052111.06739141
43Notch signaling pathway_Homo sapiens_hsa043301.06371513
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04555215
45Endocytosis_Homo sapiens_hsa041441.04340139
46TNF signaling pathway_Homo sapiens_hsa046681.04189038
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.99466857
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.98740316
49Shigellosis_Homo sapiens_hsa051310.98188708
50Insulin resistance_Homo sapiens_hsa049310.95457617
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94648445
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93752766
53Protein digestion and absorption_Homo sapiens_hsa049740.93106105
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92931179
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91377202
56African trypanosomiasis_Homo sapiens_hsa051430.87147770
57Chemokine signaling pathway_Homo sapiens_hsa040620.84596652
58Tuberculosis_Homo sapiens_hsa051520.84350290
59HIF-1 signaling pathway_Homo sapiens_hsa040660.84114639
60TGF-beta signaling pathway_Homo sapiens_hsa043500.83418311
61GnRH signaling pathway_Homo sapiens_hsa049120.82974200
62Rheumatoid arthritis_Homo sapiens_hsa053230.82038970
63Bladder cancer_Homo sapiens_hsa052190.79445683
64Axon guidance_Homo sapiens_hsa043600.79272526
65Pancreatic cancer_Homo sapiens_hsa052120.79075194
66Hepatitis C_Homo sapiens_hsa051600.78991663
67Pathways in cancer_Homo sapiens_hsa052000.76787042
68Fat digestion and absorption_Homo sapiens_hsa049750.76534478
69Renin-angiotensin system_Homo sapiens_hsa046140.76214257
70PPAR signaling pathway_Homo sapiens_hsa033200.73869554
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.73028858
72Ovarian steroidogenesis_Homo sapiens_hsa049130.72387155
73Mineral absorption_Homo sapiens_hsa049780.70235678
74Hematopoietic cell lineage_Homo sapiens_hsa046400.69914498
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69596358
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69423419
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.69301126
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.69285402
79Chronic myeloid leukemia_Homo sapiens_hsa052200.68932130
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68826687
81Histidine metabolism_Homo sapiens_hsa003400.68776496
82Prion diseases_Homo sapiens_hsa050200.67802555
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66963817
84Ras signaling pathway_Homo sapiens_hsa040140.66650724
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66633187
86Apoptosis_Homo sapiens_hsa042100.64267538
87Estrogen signaling pathway_Homo sapiens_hsa049150.64115288
88Bile secretion_Homo sapiens_hsa049760.63558626
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63274957
90Influenza A_Homo sapiens_hsa051640.63045974
91Pancreatic secretion_Homo sapiens_hsa049720.62730261
92Gap junction_Homo sapiens_hsa045400.60727294
93Measles_Homo sapiens_hsa051620.58749227
94B cell receptor signaling pathway_Homo sapiens_hsa046620.58413463
95Legionellosis_Homo sapiens_hsa051340.58378468
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58187976
97Gastric acid secretion_Homo sapiens_hsa049710.58124106
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.57598551
99MicroRNAs in cancer_Homo sapiens_hsa052060.53550530
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53407606
101Glycerolipid metabolism_Homo sapiens_hsa005610.51398053
102Tryptophan metabolism_Homo sapiens_hsa003800.50872392
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50515523
104Fatty acid degradation_Homo sapiens_hsa000710.50432925
105Hippo signaling pathway_Homo sapiens_hsa043900.50271773
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49045036
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48957609
108Other glycan degradation_Homo sapiens_hsa005110.48582919
109Acute myeloid leukemia_Homo sapiens_hsa052210.47861296
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46295175
111Nitrogen metabolism_Homo sapiens_hsa009100.46252788
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46181004
113cAMP signaling pathway_Homo sapiens_hsa040240.46111938
114Salivary secretion_Homo sapiens_hsa049700.45929242
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45532281
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44649081
117Arginine and proline metabolism_Homo sapiens_hsa003300.41547827
118Arachidonic acid metabolism_Homo sapiens_hsa005900.38891752
119Thyroid hormone synthesis_Homo sapiens_hsa049180.38653936
120Oxytocin signaling pathway_Homo sapiens_hsa049210.36591131
121MAPK signaling pathway_Homo sapiens_hsa040100.36299972
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.36168364
123Melanogenesis_Homo sapiens_hsa049160.35438766

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