ACY3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.11741000
2urate metabolic process (GO:0046415)9.10302341
3regulation of plasminogen activation (GO:0010755)8.91469387
4lysine metabolic process (GO:0006553)7.72008304
5lysine catabolic process (GO:0006554)7.72008304
6aminoglycoside antibiotic metabolic process (GO:0030647)7.70756084
7drug transport (GO:0015893)7.66439673
8glyoxylate metabolic process (GO:0046487)7.48612146
9cysteine metabolic process (GO:0006534)6.99803501
10organic cation transport (GO:0015695)6.96950062
11folic acid-containing compound biosynthetic process (GO:0009396)6.75243621
12exogenous drug catabolic process (GO:0042738)6.70947058
13drug catabolic process (GO:0042737)6.70042505
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.56606257
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.56606257
16phosphate ion transport (GO:0006817)6.52795407
17L-phenylalanine catabolic process (GO:0006559)6.45102296
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.45102296
19L-phenylalanine metabolic process (GO:0006558)6.39485047
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.39485047
21purine nucleotide salvage (GO:0032261)6.35719186
22aromatic amino acid family catabolic process (GO:0009074)6.12417224
23indole-containing compound catabolic process (GO:0042436)5.81881909
24indolalkylamine catabolic process (GO:0046218)5.81881909
25tryptophan catabolic process (GO:0006569)5.81881909
26quaternary ammonium group transport (GO:0015697)5.76841146
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.70714058
28desmosome organization (GO:0002934)5.66905926
29phosphate ion transmembrane transport (GO:0035435)5.62995899
30adenosine metabolic process (GO:0046085)5.59986483
31response to mercury ion (GO:0046689)5.51321103
32serine family amino acid catabolic process (GO:0009071)5.51157056
33tryptophan metabolic process (GO:0006568)5.49846419
34short-chain fatty acid metabolic process (GO:0046459)5.46243054
35lipoprotein transport (GO:0042953)5.43443164
36aspartate family amino acid catabolic process (GO:0009068)5.37580645
37white fat cell differentiation (GO:0050872)5.34688622
38tricarboxylic acid metabolic process (GO:0072350)5.28457758
39regulation of vitamin metabolic process (GO:0030656)5.21439204
40epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.20013110
41serine family amino acid metabolic process (GO:0009069)5.08730608
42homocysteine metabolic process (GO:0050667)5.07844120
43branched-chain amino acid metabolic process (GO:0009081)5.07512261
44cellular modified amino acid catabolic process (GO:0042219)5.05220505
45microtubule nucleation (GO:0007020)4.98798858
46amino-acid betaine metabolic process (GO:0006577)4.96898661
47nonribosomal peptide biosynthetic process (GO:0019184)4.95039020
48kynurenine metabolic process (GO:0070189)4.77755595
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.75995774
50regulation of vitamin D biosynthetic process (GO:0060556)4.75421545
51cellular ketone body metabolic process (GO:0046950)4.75083703
52valine metabolic process (GO:0006573)4.74977558
53sulfur amino acid catabolic process (GO:0000098)4.66809154
542-oxoglutarate metabolic process (GO:0006103)4.61079366
55alternative mRNA splicing, via spliceosome (GO:0000380)4.59956121
56negative regulation of DNA biosynthetic process (GO:2000279)4.57870727
57serine family amino acid biosynthetic process (GO:0009070)4.55325428
58glutathione biosynthetic process (GO:0006750)4.51662787
59aromatic amino acid family metabolic process (GO:0009072)4.51203135
60angiotensin maturation (GO:0002003)4.50718648
61fatty acid beta-oxidation (GO:0006635)4.50303728
62protein-chromophore linkage (GO:0018298)4.46079238
63alpha-amino acid catabolic process (GO:1901606)4.45365371
64cellular amino acid catabolic process (GO:0009063)4.44001055
65epoxygenase P450 pathway (GO:0019373)4.41978136
66galactose catabolic process (GO:0019388)4.38813136
67branched-chain amino acid catabolic process (GO:0009083)4.37580666
68glutamate metabolic process (GO:0006536)4.34034129
69acetyl-CoA metabolic process (GO:0006084)4.33485830
70positive regulation of endothelial cell differentiation (GO:0045603)4.31979511
71proline metabolic process (GO:0006560)4.30188467
72pteridine-containing compound biosynthetic process (GO:0042559)4.29703114
73carnitine transport (GO:0015879)4.29191360
74amino-acid betaine transport (GO:0015838)4.29191360
75fatty acid oxidation (GO:0019395)4.28390496
76excretion (GO:0007588)4.21486518
77lipid oxidation (GO:0034440)4.20032577
78vitamin D metabolic process (GO:0042359)4.20002784
79glycoside metabolic process (GO:0016137)4.19922872
80carnitine metabolic process (GO:0009437)4.19831655
81L-serine metabolic process (GO:0006563)4.17800503
82bile acid biosynthetic process (GO:0006699)4.16995151
83fructose metabolic process (GO:0006000)4.14926643
84galactose metabolic process (GO:0006012)4.14318972
85cell migration involved in heart development (GO:0060973)4.14183010
86ketone body metabolic process (GO:1902224)4.10192905
87indolalkylamine metabolic process (GO:0006586)4.09058838
88benzene-containing compound metabolic process (GO:0042537)4.09033242
89phosphatidylglycerol biosynthetic process (GO:0006655)4.08345744
90renal absorption (GO:0070293)4.04677108
91phosphate ion homeostasis (GO:0055062)4.04532377
92trivalent inorganic anion homeostasis (GO:0072506)4.04532377
93toxin transport (GO:1901998)4.04357563
94glucuronate metabolic process (GO:0019585)4.02794010
95uronic acid metabolic process (GO:0006063)4.02794010
96regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.01544631
97carboxylic acid catabolic process (GO:0046395)3.99312563
98organic acid catabolic process (GO:0016054)3.99312563
99cellular glucuronidation (GO:0052695)3.99076228
100flavonoid metabolic process (GO:0009812)3.92913189
101fatty acid catabolic process (GO:0009062)3.92409425
102inner ear receptor cell development (GO:0060119)3.91313524
103receptor guanylyl cyclase signaling pathway (GO:0007168)3.89657371
104amine catabolic process (GO:0009310)3.85975295
105cellular biogenic amine catabolic process (GO:0042402)3.85975295
106drug metabolic process (GO:0017144)3.84795502
107negative regulation of catenin import into nucleus (GO:0035414)3.84384475
108regulation of sequestering of triglyceride (GO:0010889)3.83359314
109monocarboxylic acid catabolic process (GO:0072329)3.82473385
110negative regulation of keratinocyte proliferation (GO:0010839)3.82262016
111response to phenylpropanoid (GO:0080184)3.80538008
112urea cycle (GO:0000050)3.79280104
113urea metabolic process (GO:0019627)3.79129231
114aldehyde catabolic process (GO:0046185)3.78709290
115indole-containing compound metabolic process (GO:0042430)3.75456286
116negative regulation of Ras GTPase activity (GO:0034261)3.74069089
117nucleotide salvage (GO:0043173)3.71520573
118modified amino acid transport (GO:0072337)3.70367259
119positive regulation of lipoprotein lipase activity (GO:0051006)3.69940539
120positive regulation of triglyceride lipase activity (GO:0061365)3.69940539
121primary amino compound metabolic process (GO:1901160)3.69870536
122regulation of triglyceride catabolic process (GO:0010896)3.67247579
123mitochondrial RNA metabolic process (GO:0000959)3.66594038
124glutathione metabolic process (GO:0006749)3.65946672
125regulation of tight junction assembly (GO:2000810)3.65822917
126nucleoside transmembrane transport (GO:1901642)3.64467555
127tetrahydrofolate metabolic process (GO:0046653)3.63659225
128COPII vesicle coating (GO:0048208)3.61081390
129glycosphingolipid catabolic process (GO:0046479)3.58855325
130peptide biosynthetic process (GO:0043043)3.57093446
131regulation of cholesterol esterification (GO:0010872)3.56403504
132folic acid-containing compound metabolic process (GO:0006760)3.55876567
133dicarboxylic acid metabolic process (GO:0043648)3.55130724
134metanephric nephron tubule development (GO:0072234)3.52908284
135metanephric tubule development (GO:0072170)3.52908284
136dicarboxylic acid biosynthetic process (GO:0043650)3.50204323
137heme transport (GO:0015886)3.49420490
138sodium-independent organic anion transport (GO:0043252)3.49279798
139response to growth hormone (GO:0060416)3.48577343
140glutathione derivative biosynthetic process (GO:1901687)3.45499536
141glutathione derivative metabolic process (GO:1901685)3.45499536
142small molecule catabolic process (GO:0044282)3.45308977
143tyrosine metabolic process (GO:0006570)3.44987517
144positive regulation of fatty acid metabolic process (GO:0045923)3.43860165
145regulation of cholesterol homeostasis (GO:2000188)3.43422837
146regulation of gonadotropin secretion (GO:0032276)3.42568812
147glycolipid catabolic process (GO:0019377)3.40336465
148nitrogen cycle metabolic process (GO:0071941)3.40244306
149biotin metabolic process (GO:0006768)3.38036571
150response to vitamin A (GO:0033189)3.36205810
151alpha-linolenic acid metabolic process (GO:0036109)3.35977825
152peptide catabolic process (GO:0043171)3.35730921
153glycine metabolic process (GO:0006544)3.35193833
154ethanol oxidation (GO:0006069)3.34058564
155sulfur amino acid metabolic process (GO:0000096)3.33766077
156hormone catabolic process (GO:0042447)3.31026210
157triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30875700
158regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.30131364
159cochlea development (GO:0090102)3.29999849
160cartilage morphogenesis (GO:0060536)3.29991313
161histone H4-K12 acetylation (GO:0043983)3.29980027
162regulation of cholesterol storage (GO:0010885)3.27997439
163sulfur amino acid biosynthetic process (GO:0000097)3.20637548
164negative regulation of blood vessel endothelial cell migration (GO:0043537)3.12419780
165glycosylceramide metabolic process (GO:0006677)3.11652748
166bile acid metabolic process (GO:0008206)3.11400729
167regulation of endothelial cell differentiation (GO:0045601)3.05198773
168positive regulation of fatty acid biosynthetic process (GO:0045723)3.02605495
169bile acid and bile salt transport (GO:0015721)3.01839794
170ceramide catabolic process (GO:0046514)2.99924540
171NADH metabolic process (GO:0006734)2.96019169
172alpha-amino acid biosynthetic process (GO:1901607)2.96001503
173IMP biosynthetic process (GO:0006188)2.94223551
174protein-lipid complex remodeling (GO:0034368)2.94216939
175macromolecular complex remodeling (GO:0034367)2.94216939
176plasma lipoprotein particle remodeling (GO:0034369)2.94216939
177lipoprotein metabolic process (GO:0042157)2.93583867
178fat-soluble vitamin biosynthetic process (GO:0042362)2.90887801
179omega-hydroxylase P450 pathway (GO:0097267)2.89478705
180polyamine biosynthetic process (GO:0006596)2.89470073
181pteridine-containing compound metabolic process (GO:0042558)2.78203612
182negative regulation of interleukin-1 beta production (GO:0032691)2.77424649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.51876593
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.23516506
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.25732012
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.40191303
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.29418489
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.36587246
7* IRF8_22096565_ChIP-ChIP_GC-B_Human4.07305109
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.69152038
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.55262735
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.15004182
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.95913733
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87579811
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.85933867
14* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.70560591
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.41275580
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.22065247
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.15186959
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13691585
19CLOCK_20551151_ChIP-Seq_293T_Human2.01324404
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse11.3366815
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.72297910
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.68383112
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67685633
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.67533858
25E2F7_22180533_ChIP-Seq_HELA_Human1.64640493
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61989595
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60976470
28AR_21909140_ChIP-Seq_LNCAP_Human1.59591477
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58518259
30* FOXA2_19822575_ChIP-Seq_HepG2_Human1.57533663
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57373747
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57138755
33STAT1_20625510_ChIP-Seq_HELA_Human1.50821929
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50309171
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.47473724
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46562216
37BCOR_27268052_Chip-Seq_Bcells_Human1.42492009
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.42298309
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.42269692
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41205991
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40790201
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39970226
43GATA4_25053715_ChIP-Seq_YYC3_Human1.33980948
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.33361438
45STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.31060720
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29583765
47P300_27268052_Chip-Seq_Bcells_Human1.28763107
48SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25988693
49* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24926525
50PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24808108
51LXR_22292898_ChIP-Seq_THP-1_Human1.24502936
52* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23709021
53FOXH1_21741376_ChIP-Seq_ESCs_Human1.20061810
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16748161
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15372755
56BCL6_27268052_Chip-Seq_Bcells_Human1.13992631
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13799576
58FLI1_21867929_ChIP-Seq_CD8_Mouse1.12996783
59* ETS1_21867929_ChIP-Seq_TH2_Mouse1.12948024
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12678237
61* NCOR_22424771_ChIP-Seq_293T_Human1.11547108
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10679432
63RACK7_27058665_Chip-Seq_MCF-7_Human1.06440607
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03695204
65OCT1_27270436_Chip-Seq_PROSTATE_Human1.02480990
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02172965
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01651769
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01040512
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98138146
70VDR_22108803_ChIP-Seq_LS180_Human0.97881272
71SA1_27219007_Chip-Seq_Bcells_Human0.96746630
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96138568
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95845923
74GATA6_25053715_ChIP-Seq_YYC3_Human0.95569964
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95070139
76ERG_20517297_ChIP-Seq_VCAP_Human0.94964956
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.93868636
78JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93826295
79EGR1_19032775_ChIP-ChIP_M12_Human0.91737885
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91526686
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90864213
82* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90343804
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89599194
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89408414
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87877496
86E2F1_20622854_ChIP-Seq_HELA_Human0.87820894
87SPI1_23547873_ChIP-Seq_NB4_Human0.87816076
88SOX11_22085726_ChIP-Seq_ESNs_Mouse0.87034027
89TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86445640
90CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85702547
91NANOG_20526341_ChIP-Seq_ESCs_Human0.85311396
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85011927
93SOX2_21211035_ChIP-Seq_LN229_Human0.84674190
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84416484
95SCL_19346495_ChIP-Seq_HPC-7_Human0.84193701
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84011008
97* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83756930
98TBX20_22080862_ChIP-Seq_HEART_Mouse0.83505648
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.83505648
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82656010
101VDR_21846776_ChIP-Seq_THP-1_Human0.81197462
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80533563
103BCAT_22108803_ChIP-Seq_LS180_Human0.80313590
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79983645
105* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79480269
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.79032173
107OCT4_20526341_ChIP-Seq_ESCs_Human0.78856834
108TP53_22127205_ChIP-Seq_IMR90_Human0.78780164
109BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78672175
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77610342
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77574001
112MYC_19915707_ChIP-ChIP_AK7_Human0.77484398
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77389396
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76626784
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76197203
116TCF4_18268006_ChIP-ChIP_LS174T_Human0.76022412
117CEBPB_22108803_ChIP-Seq_LS180_Human0.75492369
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75150872
119SOX2_20726797_ChIP-Seq_SW620_Human0.73913588
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.73172914
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72591948
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72476477
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71936623
124ZNF263_19887448_ChIP-Seq_K562_Human0.70908917
125RAC3_21632823_ChIP-Seq_H3396_Human0.70025930
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69438810
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68146755
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66884951
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.66551967
130KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66245805
131AR_20517297_ChIP-Seq_VCAP_Human0.65948276
132EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.65539679
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64840872
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64694721
135P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.64527608
136CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63099851
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.62949946
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61815642
139ESET_19884257_ChIP-Seq_ESCs_Mouse0.61780476
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61737886
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61737886
142* TAF2_19829295_ChIP-Seq_ESCs_Human0.61728714
143CDX2_22108803_ChIP-Seq_LS180_Human0.61603251
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61482853
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.61433376
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.61305032
147CSB_26484114_Chip-Seq_FIBROBLAST_Human0.60385760
148GATA2_19941826_ChIP-Seq_K562_Human0.60351339
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60182761
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.60138929
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58838624
152NANOG_18692474_ChIP-Seq_MEFs_Mouse0.56530329
153CBP_21632823_ChIP-Seq_H3396_Human0.56087621
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.55746780
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55443525
156GATA1_22025678_ChIP-Seq_K562_Human0.54897424
157SMC4_20622854_ChIP-Seq_HELA_Human0.54531533
158P68_20966046_ChIP-Seq_HELA_Human0.54516118
159GATA1_19941827_ChIP-Seq_MEL_Mouse0.53924930
160CTCF_27219007_Chip-Seq_Bcells_Human0.53672756
161CREB1_26743006_Chip-Seq_LNCaP_Human0.51797113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.58168041
2MP0002139_abnormal_hepatobiliary_system6.91656230
3MP0003183_abnormal_peptide_metabolism4.92041649
4MP0005332_abnormal_amino_acid4.69237356
5MP0004043_abnormal_pH_regulation4.44496616
6MP0004019_abnormal_vitamin_homeostasis4.35296873
7MP0008875_abnormal_xenobiotic_pharmacok4.21277566
8MP0005085_abnormal_gallbladder_physiolo4.08203514
9MP0005365_abnormal_bile_salt3.90138826
10MP0003195_calcinosis3.54936305
11MP0002138_abnormal_hepatobiliary_system3.45487363
12MP0009643_abnormal_urine_homeostasis3.29703310
13MP0003252_abnormal_bile_duct3.10704623
14MP0005646_abnormal_pituitary_gland3.09264817
15MP0002396_abnormal_hematopoietic_system2.91607951
16MP0003806_abnormal_nucleotide_metabolis2.79096958
17MP0001765_abnormal_ion_homeostasis2.73054194
18MP0000013_abnormal_adipose_tissue2.64137493
19MP0005636_abnormal_mineral_homeostasis2.57053823
20MP0001756_abnormal_urination2.30407744
21MP0002136_abnormal_kidney_physiology2.21998403
22MP0008995_early_reproductive_senescence2.08251342
23MP0003186_abnormal_redox_activity1.87899464
24MP0002736_abnormal_nociception_after1.83559521
25MP0010329_abnormal_lipoprotein_level1.83083096
26MP0005584_abnormal_enzyme/coenzyme_acti1.80439926
27MP0003878_abnormal_ear_physiology1.78638293
28MP0005377_hearing/vestibular/ear_phenot1.78638293
29MP0005058_abnormal_lysosome_morphology1.76179273
30MP0005319_abnormal_enzyme/_coenzyme1.76158131
31MP0001666_abnormal_nutrient_absorption1.75433226
32MP0000516_abnormal_urinary_system1.63981398
33MP0005367_renal/urinary_system_phenotyp1.63981398
34MP0001958_emphysema1.63676904
35MP0009697_abnormal_copulation1.63113486
36MP0003191_abnormal_cellular_cholesterol1.56259421
37MP0008872_abnormal_physiological_respon1.53099211
38MP0004185_abnormal_adipocyte_glucose1.47091478
39MP0002118_abnormal_lipid_homeostasis1.46564907
40MP0005084_abnormal_gallbladder_morpholo1.46176968
41MP0005451_abnormal_body_composition1.41834356
42MP0001764_abnormal_homeostasis1.40750351
43MP0002938_white_spotting1.35306989
44MP0005083_abnormal_biliary_tract1.34130077
45MP0006036_abnormal_mitochondrial_physio1.33930652
46MP0000678_abnormal_parathyroid_gland1.32908845
47MP0000609_abnormal_liver_physiology1.30461599
48MP0002132_abnormal_respiratory_system1.29755266
49MP0002876_abnormal_thyroid_physiology1.24602260
50MP0000538_abnormal_urinary_bladder1.22865228
51MP0009840_abnormal_foam_cell1.20171359
52MP0005670_abnormal_white_adipose1.14837005
53MP0000003_abnormal_adipose_tissue1.10152002
54MP0010155_abnormal_intestine_physiology1.09742496
55MP0008961_abnormal_basal_metabolism1.05441656
56MP0004885_abnormal_endolymph1.05021064
57MP0002928_abnormal_bile_duct1.01781578
58MP0005535_abnormal_body_temperature1.00850690
59MP0001968_abnormal_touch/_nociception0.94238728
60MP0009379_abnormal_foot_pigmentation0.93757194
61MP0005666_abnormal_adipose_tissue0.91702458
62MP0000230_abnormal_systemic_arterial0.91634645
63MP0000534_abnormal_ureter_morphology0.91234949
64MP0001835_abnormal_antigen_presentation0.91000526
65MP0002168_other_aberrant_phenotype0.88960250
66MP0002095_abnormal_skin_pigmentation0.88428776
67MP0009642_abnormal_blood_homeostasis0.88409288
68MP0001800_abnormal_humoral_immune0.87905397
69MP0004147_increased_porphyrin_level0.87047515
70MP0000598_abnormal_liver_morphology0.86264669
71MP0009764_decreased_sensitivity_to0.84825018
72MP0002135_abnormal_kidney_morphology0.82202831
73MP0003300_gastrointestinal_ulcer0.82047666
74MP0009115_abnormal_fat_cell0.80230823
75MP0002735_abnormal_chemical_nociception0.77959997
76MP0001661_extended_life_span0.77294200
77MP0008469_abnormal_protein_level0.75187172
78MP0005409_darkened_coat_color0.73784389
79MP0003638_abnormal_response/metabolism_0.72620475
80MP0002089_abnormal_postnatal_growth/wei0.72408733
81MP0005408_hypopigmentation0.70690028
82MP0003705_abnormal_hypodermis_morpholog0.70053261
83MP0004264_abnormal_extraembryonic_tissu0.69165812
84MP0005000_abnormal_immune_tolerance0.69051241
85MP0003646_muscle_fatigue0.67989842
86MP0001851_eye_inflammation0.67759901
87MP0003045_fibrosis0.67313257
88MP0005164_abnormal_response_to0.65489461
89MP0002148_abnormal_hypersensitivity_rea0.65086138
90MP0005220_abnormal_exocrine_pancreas0.64987290
91MP0003866_abnormal_defecation0.64789995
92MP0002896_abnormal_bone_mineralization0.64549184
93MP0000249_abnormal_blood_vessel0.64386697
94MP0002078_abnormal_glucose_homeostasis0.63050291
95MP0005166_decreased_susceptibility_to0.62375104
96MP0002796_impaired_skin_barrier0.62113516
97MP0001986_abnormal_taste_sensitivity0.61902801
98MP0003329_amyloid_beta_deposits0.61547958
99MP0009333_abnormal_splenocyte_physiolog0.61315055
100MP0006035_abnormal_mitochondrial_morpho0.60181319
101MP0002006_tumorigenesis0.59688326
102MP0005395_other_phenotype0.58512778
103MP0000747_muscle_weakness0.58365380
104MP0003172_abnormal_lysosome_physiology0.56624524
105MP0001533_abnormal_skeleton_physiology0.56324269
106MP0000681_abnormal_thyroid_gland0.54974693
107MP0005551_abnormal_eye_electrophysiolog0.52799721
108MP0003718_maternal_effect0.52783826
109MP0001270_distended_abdomen0.52278841
110MP0002723_abnormal_immune_serum0.52103019
111MP0003868_abnormal_feces_composition0.51562002
112MP0002419_abnormal_innate_immunity0.51341643
113MP0010234_abnormal_vibrissa_follicle0.51272285
114MP0002452_abnormal_antigen_presenting0.50807852
115MP0001944_abnormal_pancreas_morphology0.49909129
116MP0000604_amyloidosis0.49178022
117MP0002971_abnormal_brown_adipose0.48721775
118MP0005376_homeostasis/metabolism_phenot0.48655302
119MP0001663_abnormal_digestive_system0.48510748
120MP0009765_abnormal_xenobiotic_induced0.47478034
121MP0000371_diluted_coat_color0.46430408
122MP0003953_abnormal_hormone_level0.46291978
123MP0003436_decreased_susceptibility_to0.46015441
124MP0003724_increased_susceptibility_to0.45012572
125MP0003959_abnormal_lean_body0.43532189
126MP0009763_increased_sensitivity_to0.43409269
127MP0005647_abnormal_sex_gland0.42756655
128MP0003283_abnormal_digestive_organ0.41248028
129MP0005501_abnormal_skin_physiology0.40929383
130MP0005266_abnormal_metabolism0.40678042
131MP0009672_abnormal_birth_weight0.39860136
132MP0005167_abnormal_blood-brain_barrier0.39164440
133MP0002837_dystrophic_cardiac_calcinosis0.36616678
134MP0005165_increased_susceptibility_to0.36088933
135MP0003879_abnormal_hair_cell0.35688806
136MP0005375_adipose_tissue_phenotype0.35599837
137MP0002115_abnormal_skeleton_extremities0.32371599
138MP0005334_abnormal_fat_pad0.32261235
139MP0003690_abnormal_glial_cell0.31837954
140MP0002069_abnormal_eating/drinking_beha0.30931878
141MP0003221_abnormal_cardiomyocyte_apopto0.29770942
142MP0005330_cardiomyopathy0.29516430
143MP0004130_abnormal_muscle_cell0.29269431
144MP0002098_abnormal_vibrissa_morphology0.28661110
145MP0003075_altered_response_to0.28638592
146MP0008874_decreased_physiological_sensi0.26617217
147MP0001845_abnormal_inflammatory_respons0.25970623

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.38777145
2Abnormality of alanine metabolism (HP:0010916)7.38777145
3Hyperalaninemia (HP:0003348)7.38777145
4Gout (HP:0001997)6.64432296
5Congenital sensorineural hearing impairment (HP:0008527)5.84463864
6Increased circulating renin level (HP:0000848)5.69046938
7Metabolic alkalosis (HP:0200114)5.58781017
8Hypokalemic alkalosis (HP:0001949)5.57833427
9Spontaneous hematomas (HP:0007420)5.40990516
10Constricted visual fields (HP:0001133)5.32666178
11Hyperglycinuria (HP:0003108)5.31284989
12Hypomagnesemia (HP:0002917)5.24331405
13Proximal tubulopathy (HP:0000114)5.20295430
14Abnormality of glutamine family amino acid metabolism (HP:0010902)5.19689916
15Hyperactive renin-angiotensin system (HP:0000841)5.16060148
16Polyuria (HP:0000103)5.08463871
17Abnormal urine output (HP:0012590)4.88955496
18Abnormality of chloride homeostasis (HP:0011422)4.85025688
19Increased purine levels (HP:0004368)4.80149931
20Hyperuricemia (HP:0002149)4.80149931
21Esophageal varix (HP:0002040)4.78965592
22Abnormality of renal excretion (HP:0011036)4.72024172
23Abnormality of purine metabolism (HP:0004352)4.68507091
24Abnormality of glycine metabolism (HP:0010895)4.60990278
25Abnormality of serine family amino acid metabolism (HP:0010894)4.60990278
26White forelock (HP:0002211)4.54048886
27Abnormal umbilical cord blood vessels (HP:0011403)4.45401845
28Single umbilical artery (HP:0001195)4.45401845
29Abnormality of the fetal cardiovascular system (HP:0010948)4.45401845
30Abnormality of magnesium homeostasis (HP:0004921)4.44940801
31Generalized aminoaciduria (HP:0002909)4.39070596
32Alkalosis (HP:0001948)4.26739256
33Ketosis (HP:0001946)4.22018999
34Ketoacidosis (HP:0001993)4.19409107
35Patchy hypopigmentation of hair (HP:0011365)4.18670631
36Abnormality of aromatic amino acid family metabolism (HP:0004338)4.11804097
37Abnormal drinking behavior (HP:0030082)4.08398060
38Polydipsia (HP:0001959)4.08398060
39Conjugated hyperbilirubinemia (HP:0002908)4.00321026
40Decreased electroretinogram (ERG) amplitude (HP:0000654)3.91369884
41Abnormality of nucleobase metabolism (HP:0010932)3.76266450
42Glycosuria (HP:0003076)3.75403962
43Abnormality of urine glucose concentration (HP:0011016)3.75403962
44Myocardial infarction (HP:0001658)3.70396007
45Hyperglycinemia (HP:0002154)3.70072962
46Conjunctival telangiectasia (HP:0000524)3.59309583
47Anorexia (HP:0002039)3.58958102
48Abnormality of aspartate family amino acid metabolism (HP:0010899)3.58253266
49Renal salt wasting (HP:0000127)3.57417489
50Abnormality of renin-angiotensin system (HP:0000847)3.56292780
51Ileus (HP:0002595)3.54356370
52Hyperaldosteronism (HP:0000859)3.51301856
53Hyperammonemia (HP:0001987)3.50468437
54Tetany (HP:0001281)3.47908246
55Delayed CNS myelination (HP:0002188)3.45997623
56Abnormality of fatty-acid metabolism (HP:0004359)3.41728782
57Pigmentary retinal degeneration (HP:0001146)3.39869725
58Intrahepatic cholestasis (HP:0001406)3.31477575
59Pulmonary embolism (HP:0002204)3.29966903
60Action tremor (HP:0002345)3.28513271
61Hypercalciuria (HP:0002150)3.27477842
62Renal tubular acidosis (HP:0001947)3.21362800
63Hyperphosphaturia (HP:0003109)3.20329409
64Homocystinuria (HP:0002156)3.16067113
65Abnormality of homocysteine metabolism (HP:0010919)3.16067113
66Vascular calcification (HP:0004934)3.14005238
67Hydroxyprolinuria (HP:0003080)3.12317238
68Abnormality of proline metabolism (HP:0010907)3.12317238
69Systemic lupus erythematosus (HP:0002725)3.09679408
70Xanthomatosis (HP:0000991)3.09152008
71Dicarboxylic aciduria (HP:0003215)3.06809132
72Abnormality of dicarboxylic acid metabolism (HP:0010995)3.06809132
73Thrombophlebitis (HP:0004418)3.03991610
74Abnormality of sulfur amino acid metabolism (HP:0004339)3.02990215
75Abnormality of the vasculature of the conjunctiva (HP:0008054)2.99848225
76Abnormal urine phosphate concentration (HP:0012599)2.97206473
77Chronic otitis media (HP:0000389)2.95491331
78Visceral angiomatosis (HP:0100761)2.93049555
79Hypoalphalipoproteinemia (HP:0003233)2.90765120
80Nephrolithiasis (HP:0000787)2.90098843
81Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87833225
82Metabolic acidosis (HP:0001942)2.87783934
83Gingival bleeding (HP:0000225)2.86220960
84Rickets (HP:0002748)2.81072070
85Cardiovascular calcification (HP:0011915)2.79797985
86Abnormality of the umbilical cord (HP:0010881)2.76689547
87Chronic diarrhea (HP:0002028)2.71740033
88Hypokalemia (HP:0002900)2.70249669
89Hypolipoproteinemia (HP:0010981)2.69610012
90Hypophosphatemia (HP:0002148)2.69531931
91Delayed epiphyseal ossification (HP:0002663)2.68635426
92Hemangiomatosis (HP:0007461)2.68537010
93Fatigue (HP:0012378)2.68518563
94Birth length less than 3rd percentile (HP:0003561)2.67094167
95Lethargy (HP:0001254)2.62981999
96Vomiting (HP:0002013)2.61811117
97Oligomenorrhea (HP:0000876)2.59438316
98Malnutrition (HP:0004395)2.58214711
99Nephrocalcinosis (HP:0000121)2.55829097
100Abnormal enzyme/coenzyme activity (HP:0012379)2.52751843
101Epidermoid cyst (HP:0200040)2.51757895
102Vacuolated lymphocytes (HP:0001922)2.51237535
103Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.47523676
104Heterochromia iridis (HP:0001100)2.46329712
105Enlarged kidneys (HP:0000105)2.45714359
106Hypobetalipoproteinemia (HP:0003563)2.42435866
107Megaloblastic anemia (HP:0001889)2.41258785
108Abnormality of serum amino acid levels (HP:0003112)2.41199287
109Abnormality of alkaline phosphatase activity (HP:0004379)2.40038491
110Methylmalonic aciduria (HP:0012120)2.34536333
111Myopathic facies (HP:0002058)2.34003915
112Confusion (HP:0001289)2.33347633
113Hypoglycemic coma (HP:0001325)2.33272352
114Widely patent fontanelles and sutures (HP:0004492)2.31053293
115Abnormality of potassium homeostasis (HP:0011042)2.30435940
116Sensorimotor neuropathy (HP:0007141)2.29042761
117Poor speech (HP:0002465)2.26941358
118Metaphyseal cupping (HP:0003021)2.26931377
119Complement deficiency (HP:0004431)2.26926673
120Irritability (HP:0000737)2.26131916
121Petechiae (HP:0000967)2.25410013
122Chorioretinal atrophy (HP:0000533)2.23734470
123Arterial thrombosis (HP:0004420)2.22392663
124Abnormal tarsal ossification (HP:0008369)2.22003032
125Biconcave vertebral bodies (HP:0004586)2.20716207
126Neonatal onset (HP:0003623)2.18064363
127Insulin-resistant diabetes mellitus (HP:0000831)2.17206895
128Deep venous thrombosis (HP:0002625)2.14374610
129Reduced subcutaneous adipose tissue (HP:0003758)2.13128108
130Dehydration (HP:0001944)2.13082342
131Pancreatitis (HP:0001733)2.12379559
132Nausea (HP:0002018)2.11234090
133Attenuation of retinal blood vessels (HP:0007843)2.10212974
134Polygenic inheritance (HP:0010982)2.09837373
135Elevated erythrocyte sedimentation rate (HP:0003565)2.09789120
136Late onset (HP:0003584)2.08792342
137Cavernous hemangioma (HP:0001048)2.04330653
138Abnormality of renal resorption (HP:0011038)2.04166179
139Toxemia of pregnancy (HP:0100603)2.03829509
140Renal tubular dysfunction (HP:0000124)2.03549972
141Elevated alkaline phosphatase (HP:0003155)2.03401754
142Hepatocellular carcinoma (HP:0001402)2.03393224
143Abnormality of the vitamin B12 metabolism (HP:0004341)2.00659326
144Symptomatic seizures (HP:0011145)2.00258917
145Spastic diplegia (HP:0001264)1.97360925
146Focal segmental glomerulosclerosis (HP:0000097)1.95781444
147Lymphangioma (HP:0100764)1.93800146
148Cerebral edema (HP:0002181)1.93632924
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93615809
150Facial shape deformation (HP:0011334)1.93515224
151Potter facies (HP:0002009)1.93515224
152Abnormality of pyrimidine metabolism (HP:0004353)1.91785166
153Fat malabsorption (HP:0002630)1.91287095
154Cone-rod dystrophy (HP:0000548)1.90557845
155Chronic sinusitis (HP:0011109)1.88057009
156Abnormality of vitamin B metabolism (HP:0004340)1.85242071
157Hypophosphatemic rickets (HP:0004912)1.84733489
158Hyponatremia (HP:0002902)1.82743084
159Abnormality of sodium homeostasis (HP:0010931)1.78427199
160Hyperbilirubinemia (HP:0002904)1.74986148
161Bilateral sensorineural hearing impairment (HP:0008619)1.74736676
162Thin bony cortex (HP:0002753)1.74169895
163Glomerulosclerosis (HP:0000096)1.72141019
164Axonal loss (HP:0003447)1.71937800
165Chondrocalcinosis (HP:0000934)1.70496272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.17784481
2WNK36.88037253
3OXSR16.25661420
4ACVR1B6.21756756
5BCKDK5.21177160
6JAK34.01674419
7STK393.63001647
8CDK93.50504262
9FGR3.45112857
10MAP4K13.04219273
11STK38L2.87348336
12RPS6KB22.74168305
13PDK42.27436993
14PDK32.27436993
15NEK12.24538930
16EPHB22.03556708
17FGFR42.02236583
18NTRK22.01775566
19CCNB11.86151090
20SGK4941.75235994
21SGK2231.75235994
22MST1R1.74700284
23WNK11.73767694
24NTRK31.57815481
25PDK21.55771493
26STK381.37390090
27ERN11.34294828
28BMPR21.30911302
29PINK11.27690074
30PRKG21.24749769
31MAP2K11.23369801
32LMTK21.19698887
33RIPK41.18172190
34KIT1.17862250
35GRK61.15992087
36SYK1.10674057
37EPHB11.10429619
38SMG11.04566016
39ADRBK11.04318482
40CSF1R0.98526139
41TIE10.97096617
42NEK60.95390939
43LRRK20.94508870
44CSNK1A10.93667000
45SIK10.88983266
46SGK30.88947112
47ABL20.88095606
48GSK3A0.85852765
49TRIB30.85784307
50MAPK110.85098108
51SGK20.84216142
52MAP3K70.80382591
53DYRK1B0.78626462
54VRK20.78066356
55MST40.78001382
56TESK20.77337444
57PTK60.75252693
58RPS6KB10.75139132
59PIK3CA0.73944728
60INSRR0.72429954
61MAP3K30.68973265
62TEC0.67243834
63ERBB40.66868655
64PTK20.66561984
65BTK0.65965341
66IRAK40.64526913
67IKBKB0.62586815
68LYN0.62338884
69PRKAA20.62184418
70MAP2K30.61865520
71MET0.61585983
72MAP2K40.61545494
73PRKAA10.60570106
74TGFBR20.59256848
75PDPK10.57228690
76FES0.56503955
77LCK0.54809851
78CAMK2B0.53149409
79LATS10.52178747
80FRK0.52085261
81CDK70.52048231
82SGK10.48109904
83CDK60.47420829
84PRKCZ0.46625837
85PKN20.46284317
86CAMK2D0.46215829
87PAK40.44922005
88MATK0.44460451
89CAMK10.43415049
90RIPK10.43171589
91MYLK0.42279675
92KDR0.41792679
93AURKA0.40024677
94PAK30.39383554
95RPS6KA10.39373224
96ITK0.39355358
97JAK20.38518168
98MAP3K110.38298021
99NME20.38262752
100GRK10.37277211
101PDK10.37179814
102IRAK30.36424618
103EGFR0.35425116
104INSR0.35146356
105HIPK20.34721391
106PIK3CG0.34533402
107MAP3K140.34375837
108MAPK150.33642622
109PRKACG0.33461433
110TNK20.32610184
111TLK10.31050301
112MAPK120.30964436
113IKBKE0.30582384
114PRKCI0.28793760
115SRC0.28534054
116NEK90.28493799
117IRAK20.28310143
118FER0.28027005
119UHMK10.27932578
120PTK2B0.27689535
121EPHA20.26518994
122MAPKAPK20.26431522
123TYK20.26378966
124PRKCE0.26166127
125DAPK10.25514833
126MAP3K130.24519923
127PRKCD0.24419252
128MAP2K60.24246864
129STK100.23160310
130SCYL20.23122615
131MAP3K100.23088071
132STK240.22904330
133NUAK10.22442147
134CDK190.22275871
135FYN0.22212510
136STK110.20233185
137MAPK40.19877298
138TBK10.18354059
139MAP3K20.17901993
140AKT20.17390726
141PRKCA0.16746398
142CSK0.15976670
143PRKD20.15878379
144PRKCQ0.13984068
145IRAK10.13255758
146PRKACA0.12795935
147BMX0.12578758
148PIM10.12528136
149CAMK40.11759423
150PRKCH0.11312688
151CSNK1G10.10535975
152ERBB20.09815563
153MTOR0.09727674
154CAMK2G0.09358790
155IGF1R0.09178889
156DAPK20.08693541
157MAP2K20.08416024
158TAOK30.08411782
159MAP3K60.08102519
160EPHA40.07875608
161FLT30.06741321
162PRKCG0.06308198

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.64504688
2Butanoate metabolism_Homo sapiens_hsa006503.47539592
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.20280550
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.19408263
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11267999
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08027696
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.97335475
8Propanoate metabolism_Homo sapiens_hsa006402.83678348
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54973450
10Tryptophan metabolism_Homo sapiens_hsa003802.53367936
11Peroxisome_Homo sapiens_hsa041462.52965590
12Fatty acid degradation_Homo sapiens_hsa000712.51535387
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.51178866
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.49647211
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.49042940
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37459665
17Pyruvate metabolism_Homo sapiens_hsa006202.22441458
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13310892
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98389650
20Arginine biosynthesis_Homo sapiens_hsa002201.96279805
21Nitrogen metabolism_Homo sapiens_hsa009101.93593106
22beta-Alanine metabolism_Homo sapiens_hsa004101.93536936
23Fatty acid metabolism_Homo sapiens_hsa012121.90072179
24Sulfur metabolism_Homo sapiens_hsa009201.85102953
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84354952
26Vitamin digestion and absorption_Homo sapiens_hsa049771.67595489
27Bile secretion_Homo sapiens_hsa049761.61203681
28Carbon metabolism_Homo sapiens_hsa012001.59930606
29Histidine metabolism_Homo sapiens_hsa003401.48956677
30PPAR signaling pathway_Homo sapiens_hsa033201.48894272
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47345693
32Arginine and proline metabolism_Homo sapiens_hsa003301.41503179
33Asthma_Homo sapiens_hsa053101.41242954
34Linoleic acid metabolism_Homo sapiens_hsa005911.39091203
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38509547
36Glutathione metabolism_Homo sapiens_hsa004801.36025157
37Selenocompound metabolism_Homo sapiens_hsa004501.35923868
38Starch and sucrose metabolism_Homo sapiens_hsa005001.35793210
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.29026622
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28628591
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.27754063
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.20447130
43Chemical carcinogenesis_Homo sapiens_hsa052041.18455014
44Phenylalanine metabolism_Homo sapiens_hsa003601.17908992
45Biosynthesis of amino acids_Homo sapiens_hsa012301.16388929
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15134135
47Lysine degradation_Homo sapiens_hsa003101.13364299
48Folate biosynthesis_Homo sapiens_hsa007901.12680182
49Graft-versus-host disease_Homo sapiens_hsa053321.08223663
50Allograft rejection_Homo sapiens_hsa053301.07653419
51Collecting duct acid secretion_Homo sapiens_hsa049661.04158518
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03599950
53Fatty acid elongation_Homo sapiens_hsa000621.01996359
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.01237904
55Autoimmune thyroid disease_Homo sapiens_hsa053201.00615525
56Retinol metabolism_Homo sapiens_hsa008300.98374717
57Ether lipid metabolism_Homo sapiens_hsa005650.93574413
58Glycerolipid metabolism_Homo sapiens_hsa005610.88225141
59Type I diabetes mellitus_Homo sapiens_hsa049400.87126271
60Complement and coagulation cascades_Homo sapiens_hsa046100.80638808
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.76338882
62Tyrosine metabolism_Homo sapiens_hsa003500.73928963
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72785224
64Other glycan degradation_Homo sapiens_hsa005110.71962225
65GABAergic synapse_Homo sapiens_hsa047270.71384267
66Fructose and mannose metabolism_Homo sapiens_hsa000510.69970528
67Serotonergic synapse_Homo sapiens_hsa047260.69392610
68Pentose phosphate pathway_Homo sapiens_hsa000300.68902627
69Steroid biosynthesis_Homo sapiens_hsa001000.67745583
70Morphine addiction_Homo sapiens_hsa050320.67478148
71Protein digestion and absorption_Homo sapiens_hsa049740.66780994
72Mineral absorption_Homo sapiens_hsa049780.65696466
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64746967
74Rheumatoid arthritis_Homo sapiens_hsa053230.63807835
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63033110
76Sulfur relay system_Homo sapiens_hsa041220.60507850
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58522149
78Metabolic pathways_Homo sapiens_hsa011000.57147772
79Systemic lupus erythematosus_Homo sapiens_hsa053220.56027600
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52639268
81ABC transporters_Homo sapiens_hsa020100.51489801
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50342559
83Primary immunodeficiency_Homo sapiens_hsa053400.48262446
84Caffeine metabolism_Homo sapiens_hsa002320.47747450
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46100383
86Fatty acid biosynthesis_Homo sapiens_hsa000610.41839525
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40441137
88Oxidative phosphorylation_Homo sapiens_hsa001900.39786147
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37600950
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37568029
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36493728
92Fat digestion and absorption_Homo sapiens_hsa049750.35776232
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33751502
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.33225332
95Nicotine addiction_Homo sapiens_hsa050330.32159943
96Renin-angiotensin system_Homo sapiens_hsa046140.30556562
97Antigen processing and presentation_Homo sapiens_hsa046120.30457375
98Lysosome_Homo sapiens_hsa041420.29162716
99Regulation of autophagy_Homo sapiens_hsa041400.28158430
100Staphylococcus aureus infection_Homo sapiens_hsa051500.28123655
101Pertussis_Homo sapiens_hsa051330.27464807
102Base excision repair_Homo sapiens_hsa034100.27255933
103One carbon pool by folate_Homo sapiens_hsa006700.27150631
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25243109
105Arachidonic acid metabolism_Homo sapiens_hsa005900.23853437
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22664443
107Dopaminergic synapse_Homo sapiens_hsa047280.21317033
108Thyroid hormone synthesis_Homo sapiens_hsa049180.20792121
109Leishmaniasis_Homo sapiens_hsa051400.19677256
110Parkinsons disease_Homo sapiens_hsa050120.18837826
111Galactose metabolism_Homo sapiens_hsa000520.18437765
112Glutamatergic synapse_Homo sapiens_hsa047240.16189671
113Alcoholism_Homo sapiens_hsa050340.15447404
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15362253
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13885447
116Cholinergic synapse_Homo sapiens_hsa047250.13389344
117African trypanosomiasis_Homo sapiens_hsa051430.12798422
118Vitamin B6 metabolism_Homo sapiens_hsa007500.12079320
119Insulin resistance_Homo sapiens_hsa049310.11174083
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.11037307
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1351089
122Huntingtons disease_Homo sapiens_hsa05016-0.1345431
123Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1342992
124Vibrio cholerae infection_Homo sapiens_hsa05110-0.1097795
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.1018876
126Cardiac muscle contraction_Homo sapiens_hsa04260-0.1003029
127Sphingolipid metabolism_Homo sapiens_hsa00600-0.0814881
128Choline metabolism in cancer_Homo sapiens_hsa05231-0.0727095
129Gastric acid secretion_Homo sapiens_hsa04971-0.0458396
130Alzheimers disease_Homo sapiens_hsa05010-0.0372966
131Glucagon signaling pathway_Homo sapiens_hsa04922-0.0355288
132AMPK signaling pathway_Homo sapiens_hsa04152-0.0068827

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