ADAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.92382913
2cell-cell recognition (GO:0009988)9.86674948
3male meiosis (GO:0007140)9.50198745
4synaptonemal complex organization (GO:0070193)8.96291933
5motile cilium assembly (GO:0044458)8.91199941
6reproduction (GO:0000003)8.90214772
7* spermatid development (GO:0007286)8.79881749
8synaptonemal complex assembly (GO:0007130)8.78491366
9cilium movement (GO:0003341)8.53438945
10regulation of female gonad development (GO:2000194)8.38177376
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.25998889
12regulation of DNA methylation (GO:0044030)7.94079647
13regulation of cilium movement (GO:0003352)7.89997621
14regulation of acrosome reaction (GO:0060046)7.80214253
15DNA methylation involved in gamete generation (GO:0043046)7.32128139
16single fertilization (GO:0007338)7.22325028
17sperm capacitation (GO:0048240)6.91067806
18female gamete generation (GO:0007292)6.63202870
19fertilization (GO:0009566)6.36647102
20male meiosis I (GO:0007141)6.27932144
21chromosome organization involved in meiosis (GO:0070192)6.13293653
22spermatogenesis (GO:0007283)6.09108413
23male gamete generation (GO:0048232)6.07063685
24oocyte development (GO:0048599)5.98941868
25negative regulation of inclusion body assembly (GO:0090084)5.96805653
26regulation of histone H3-K9 methylation (GO:0051570)5.95125401
27retinal cone cell development (GO:0046549)5.68086825
28meiotic nuclear division (GO:0007126)5.66626620
29gamete generation (GO:0007276)5.58338311
30ventricular system development (GO:0021591)5.49172259
31microtubule depolymerization (GO:0007019)5.33759403
32* cellular process involved in reproduction in multicellular organism (GO:0022412)5.28262493
33* germ cell development (GO:0007281)5.26389947
34organic cation transport (GO:0015695)5.08908252
35meiosis I (GO:0007127)5.07137475
36regulation of inclusion body assembly (GO:0090083)4.92334259
37negative regulation of reproductive process (GO:2000242)4.78532660
38seminiferous tubule development (GO:0072520)4.72684953
39cell recognition (GO:0008037)4.70644539
40protein kinase C signaling (GO:0070528)4.70627460
41regulation of microtubule-based movement (GO:0060632)4.67708723
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.62086313
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.62086313
44positive regulation of mitotic sister chromatid separation (GO:1901970)4.62086313
45histone H3-K9 demethylation (GO:0033169)4.60675448
46oogenesis (GO:0048477)4.60016528
47calcium ion-dependent exocytosis (GO:0017156)4.58533511
48meiotic cell cycle (GO:0051321)4.57334417
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.57203083
50microtubule severing (GO:0051013)4.54516398
51negative regulation of histone methylation (GO:0031061)4.51208379
52positive regulation of meiosis (GO:0045836)4.43963996
53glycine transport (GO:0015816)4.40608810
54multicellular organismal reproductive process (GO:0048609)4.38644038
55regulation of meiosis (GO:0040020)4.37644729
56monoubiquitinated protein deubiquitination (GO:0035520)4.32962983
57regulation of steroid hormone secretion (GO:2000831)4.32429231
58regulation of cell maturation (GO:1903429)4.27103111
59gene silencing by RNA (GO:0031047)4.24582180
60genitalia morphogenesis (GO:0035112)4.24118894
61positive regulation of histone H3-K4 methylation (GO:0051571)4.19516699
62positive regulation of meiotic cell cycle (GO:0051446)4.16604897
63left/right pattern formation (GO:0060972)4.15967277
64mitotic chromosome condensation (GO:0007076)4.08773730
65protein localization to cilium (GO:0061512)4.04683270
66spermatid nucleus differentiation (GO:0007289)4.01491738
67regulation of meiotic cell cycle (GO:0051445)3.96126973
68positive regulation of humoral immune response (GO:0002922)3.94183317
69protein localization to chromosome (GO:0034502)3.87486598
70regulation of meiosis I (GO:0060631)3.83690776
71positive regulation of chromosome segregation (GO:0051984)3.80783862
72positive regulation of gastrulation (GO:2000543)3.79172879
73meiotic chromosome segregation (GO:0045132)3.75463190
74protein localization to kinetochore (GO:0034501)3.71980180
75attachment of spindle microtubules to kinetochore (GO:0008608)3.71525971
76mitotic metaphase plate congression (GO:0007080)3.71051027
77chaperone-mediated protein complex assembly (GO:0051131)3.69719603
78protein polyglutamylation (GO:0018095)3.68849910
79meiotic cell cycle process (GO:1903046)3.67323620
80somite rostral/caudal axis specification (GO:0032525)3.60632913
81glycerol ether metabolic process (GO:0006662)3.60606055
82synapsis (GO:0007129)3.58891600
83intraciliary transport (GO:0042073)3.54756247
84DNA damage induced protein phosphorylation (GO:0006975)3.53294637
85protein localization to chromosome, centromeric region (GO:0071459)3.48489755
86* multicellular organismal development (GO:0007275)3.46081684
87DNA packaging (GO:0006323)3.42764261
88chromosome condensation (GO:0030261)3.42320081
89negative regulation of organelle assembly (GO:1902116)3.39928842
90nuclear pore complex assembly (GO:0051292)3.35480269
91reciprocal DNA recombination (GO:0035825)3.34847682
92reciprocal meiotic recombination (GO:0007131)3.34847682
93ether metabolic process (GO:0018904)3.32552395
94establishment of chromosome localization (GO:0051303)3.30455335
95histone exchange (GO:0043486)3.29377081
96DNA methylation or demethylation (GO:0044728)3.28099768
97nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.25077994
98axoneme assembly (GO:0035082)3.22245783
99regulation of centriole replication (GO:0046599)3.20593418
100microtubule-based movement (GO:0007018)3.19340468
101phosphorelay signal transduction system (GO:0000160)3.18918090
102protein K11-linked deubiquitination (GO:0035871)3.13374092
103relaxation of smooth muscle (GO:0044557)3.12259762
104gene silencing (GO:0016458)3.10741817
105lactate metabolic process (GO:0006089)3.08669915
106metaphase plate congression (GO:0051310)3.07615543
107paraxial mesoderm development (GO:0048339)3.04758994
108regulation of spindle checkpoint (GO:0090231)3.03713133
109amino-acid betaine transport (GO:0015838)3.02638114
110carnitine transport (GO:0015879)3.02638114
111interkinetic nuclear migration (GO:0022027)3.02024638
112mitotic sister chromatid cohesion (GO:0007064)3.01039777
113regulation of double-strand break repair via homologous recombination (GO:0010569)3.01037541
114protein refolding (GO:0042026)3.00667296
115positive regulation of reproductive process (GO:2000243)2.99711372
116cilium organization (GO:0044782)2.99169092
117carnitine transmembrane transport (GO:1902603)2.98271162
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.97124251
119negative regulation of cAMP-mediated signaling (GO:0043951)2.95796098
120positive regulation of histone methylation (GO:0031062)2.95229198
121positive regulation of uterine smooth muscle contraction (GO:0070474)2.89892808
122DNA alkylation (GO:0006305)2.88867760
123DNA methylation (GO:0006306)2.88867760
124CENP-A containing nucleosome assembly (GO:0034080)2.88379976
125regulation of reproductive process (GO:2000241)2.88256745
126nucleus organization (GO:0006997)2.86439187
127DNA modification (GO:0006304)2.86067573
128primitive streak formation (GO:0090009)2.85347049
129single strand break repair (GO:0000012)2.85059392
130regulation of protein polyubiquitination (GO:1902914)2.84046433
131cilium assembly (GO:0042384)2.83481647
132alditol metabolic process (GO:0019400)2.82300542
133nucleoside diphosphate phosphorylation (GO:0006165)2.81872231
134regulation of histone H3-K4 methylation (GO:0051569)2.81703621
135cellular component assembly involved in morphogenesis (GO:0010927)2.77493090
136cilium morphogenesis (GO:0060271)2.74822079
137nuclear pore organization (GO:0006999)2.74766582
138centriole replication (GO:0007099)2.74467609
139centriole assembly (GO:0098534)2.74275300
140microtubule polymerization or depolymerization (GO:0031109)2.72513080
141polyol catabolic process (GO:0046174)2.70221674
142glycolytic process (GO:0006096)2.69249471
143sex differentiation (GO:0007548)2.61154936
144sister chromatid cohesion (GO:0007062)2.59651517
145negative regulation of DNA repair (GO:0045738)2.56038649
146cilium or flagellum-dependent cell motility (GO:0001539)13.4308313
147fusion of sperm to egg plasma membrane (GO:0007342)13.2397608
148sperm motility (GO:0030317)12.3653121
149acrosome assembly (GO:0001675)11.1880455
150piRNA metabolic process (GO:0034587)11.0479388
151sperm-egg recognition (GO:0035036)11.0182323
152multicellular organism reproduction (GO:0032504)10.7534829
153axonemal dynein complex assembly (GO:0070286)10.4407193
154cell wall macromolecule catabolic process (GO:0016998)10.3527867
155cell wall macromolecule metabolic process (GO:0044036)10.3527867
156acrosome reaction (GO:0007340)10.2020228
157binding of sperm to zona pellucida (GO:0007339)10.1371180
158plasma membrane fusion (GO:0045026)10.0670881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.77691561
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.77377921
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.06279564
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.01728424
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.47204786
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73640187
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61169455
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53589460
9* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.36982283
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.28862403
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25771907
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22332622
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21938739
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.18936494
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.18936494
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.18936494
17GBX2_23144817_ChIP-Seq_PC3_Human2.07947352
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02606270
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01164154
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.4218045
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.99199549
22ZNF274_21170338_ChIP-Seq_K562_Hela1.98365349
23VDR_22108803_ChIP-Seq_LS180_Human1.92850853
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77253288
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.71699054
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66594100
27TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.64811936
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63541242
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59413318
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.58329266
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56753219
32E2F7_22180533_ChIP-Seq_HELA_Human1.56673383
33* STAT1_17558387_ChIP-Seq_HELA_Human1.55657285
34FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55150128
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54882378
36* TCF4_23295773_ChIP-Seq_U87_Human1.54088708
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53241400
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.52203943
39KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51137988
40GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50211059
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49829578
42AR_25329375_ChIP-Seq_VCAP_Human1.49759805
43SMAD4_21741376_ChIP-Seq_EPCs_Human1.48623726
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.44950016
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.43580781
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.43569723
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.42833463
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41478754
49SMAD4_21799915_ChIP-Seq_A2780_Human1.40930389
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40727802
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40677083
52CBP_20019798_ChIP-Seq_JUKART_Human1.40677083
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38743021
54STAT3_23295773_ChIP-Seq_U87_Human1.38310453
55* P300_19829295_ChIP-Seq_ESCs_Human1.37858074
56NANOG_20526341_ChIP-Seq_ESCs_Human1.37508001
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.37124112
58SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36350971
59GATA3_21867929_ChIP-Seq_CD8_Mouse1.35827118
60KDM2B_26808549_Chip-Seq_REH_Human1.34339442
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34064940
62* TAL1_26923725_Chip-Seq_HPCs_Mouse1.33847282
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31541032
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31466406
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31312468
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30025039
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30007903
68ER_23166858_ChIP-Seq_MCF-7_Human1.29571710
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28991638
70IGF1R_20145208_ChIP-Seq_DFB_Human1.24580125
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24216560
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22053352
73GATA3_21867929_ChIP-Seq_TH1_Mouse1.21874216
74RUNX2_22187159_ChIP-Seq_PCA_Human1.20555678
75RNF2_27304074_Chip-Seq_NSC_Mouse1.20239000
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19904480
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19787703
78SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19757866
79FOXH1_21741376_ChIP-Seq_EPCs_Human1.18897744
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18426832
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.17585262
82* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17410444
83P53_21459846_ChIP-Seq_SAOS-2_Human1.15481716
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15153661
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14454600
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14454600
87RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13004386
88IRF1_19129219_ChIP-ChIP_H3396_Human1.11392189
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.11161340
90FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11031837
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.10739288
92REST_21632747_ChIP-Seq_MESCs_Mouse1.09433454
93CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08262054
94SOX2_19829295_ChIP-Seq_ESCs_Human1.07711205
95NANOG_19829295_ChIP-Seq_ESCs_Human1.07711205
96GF1_26923725_Chip-Seq_HPCs_Mouse1.06757724
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.06267951
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.05495740
99FUS_26573619_Chip-Seq_HEK293_Human1.05294026
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03452526
101BCAT_22108803_ChIP-Seq_LS180_Human1.02514172
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02450534
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.02386102
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01139177
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00852297
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00073674
107CBP_21632823_ChIP-Seq_H3396_Human0.99912939
108GATA3_21878914_ChIP-Seq_MCF-7_Human0.99859336
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99329885
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.98796701
111PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98277553
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97913422
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97508285
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.97437254
115EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97354072
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97175430
117SPI1_26923725_Chip-Seq_HPCs_Mouse0.97005103
118* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95292572
119ERG_20517297_ChIP-Seq_VCAP_Human0.95166435
120KLF4_18555785_Chip-Seq_ESCs_Mouse0.95149724
121P300_18555785_Chip-Seq_ESCs_Mouse0.95028603
122OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94849604
123HOXB7_26014856_ChIP-Seq_BT474_Human0.94153735
124SMRT_27268052_Chip-Seq_Bcells_Human0.93924580
125ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93731166
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93028277
127ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92294501
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92236964
129KLF4_19829295_ChIP-Seq_ESCs_Human0.92162481
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.92125947
131* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91449696
132* P53_22387025_ChIP-Seq_ESCs_Mouse0.91263695
133GATA3_26560356_Chip-Seq_TH1_Human0.91224095
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.91104441
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90966335
136TCF4_22108803_ChIP-Seq_LS180_Human0.90877732
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90812734
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.90812734
139MYC_19829295_ChIP-Seq_ESCs_Human0.90641613
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90461711
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.90230610
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90145539
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89549068
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.88942538
145RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88768013
146OCT4_20526341_ChIP-Seq_ESCs_Human0.88269600
147E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87764236
148RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87720648
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.87208015
150LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86852694
151TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86560602
152SOX2_21211035_ChIP-Seq_LN229_Human0.86282016
153NFYB_21822215_ChIP-Seq_K562_Human0.85283620
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85278458
155* NCOR_22424771_ChIP-Seq_293T_Human0.84966684
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84636520
157* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84386753
158SOX9_26525672_Chip-Seq_HEART_Mouse0.83757622
159TP53_22573176_ChIP-Seq_HFKS_Human0.83594328
160RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83468625
161EWS_26573619_Chip-Seq_HEK293_Human0.83236150
162TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83080242
163* STAT3_18555785_Chip-Seq_ESCs_Mouse0.83051797
164MYC_27129775_Chip-Seq_CORNEA_Mouse0.82504200
165HTT_18923047_ChIP-ChIP_STHdh_Human0.82286485
166GF1B_26923725_Chip-Seq_HPCs_Mouse0.82254579
167DROSHA_22980978_ChIP-Seq_HELA_Human0.82229832
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.81458381
169RAC3_21632823_ChIP-Seq_H3396_Human0.80971832
170BP1_19119308_ChIP-ChIP_Hs578T_Human0.79542419
171CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78746670
172OCT1_27270436_Chip-Seq_PROSTATE_Human0.78262206
173CDX2_22108803_ChIP-Seq_LS180_Human0.77434833
174ARNT_22903824_ChIP-Seq_MCF-7_Human0.77387146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.30971957
2MP0008877_abnormal_DNA_methylation6.34994412
3* MP0003698_abnormal_male_reproductive6.05737308
4* MP0001929_abnormal_gametogenesis5.65340391
5MP0002210_abnormal_sex_determination4.10619910
6MP0006292_abnormal_olfactory_placode3.80029972
7MP0008789_abnormal_olfactory_epithelium3.48389942
8MP0001145_abnormal_male_reproductive3.44428925
9MP0002653_abnormal_ependyma_morphology3.43320527
10* MP0002161_abnormal_fertility/fecundity3.27814608
11MP0005395_other_phenotype3.15506883
12MP0003890_abnormal_embryonic-extraembry3.08359778
13MP0005499_abnormal_olfactory_system2.99671075
14MP0005394_taste/olfaction_phenotype2.99671075
15MP0000653_abnormal_sex_gland2.98807462
16MP0003136_yellow_coat_color2.81935953
17MP0002138_abnormal_hepatobiliary_system2.71023474
18MP0005360_urolithiasis2.30967965
19MP0002139_abnormal_hepatobiliary_system2.26935379
20MP0003693_abnormal_embryo_hatching2.21688148
21MP0005623_abnormal_meninges_morphology2.14971074
22MP0000566_synostosis2.12316263
23* MP0005410_abnormal_fertilization14.5668573
24MP0002160_abnormal_reproductive_system1.94215507
25MP0008057_abnormal_DNA_replication1.87598680
26MP0005670_abnormal_white_adipose1.86344506
27MP0010030_abnormal_orbit_morphology1.77040139
28MP0002837_dystrophic_cardiac_calcinosis1.75839274
29MP0008995_early_reproductive_senescence1.73527217
30MP0008058_abnormal_DNA_repair1.64888989
31MP0005085_abnormal_gallbladder_physiolo1.51912394
32MP0003646_muscle_fatigue1.49255358
33MP0003183_abnormal_peptide_metabolism1.46040854
34MP0000678_abnormal_parathyroid_gland1.45834612
35MP0002282_abnormal_trachea_morphology1.43802283
36MP0005171_absent_coat_pigmentation1.36358941
37MP0010094_abnormal_chromosome_stability1.32412976
38MP0005647_abnormal_sex_gland1.25922736
39MP0003786_premature_aging1.17307467
40MP0003121_genomic_imprinting1.16017481
41MP0004233_abnormal_muscle_weight1.11211216
42MP0002272_abnormal_nervous_system1.10863496
43MP0005646_abnormal_pituitary_gland1.09082405
44MP0003252_abnormal_bile_duct1.05661732
45MP0000631_abnormal_neuroendocrine_gland1.05073360
46MP0008932_abnormal_embryonic_tissue1.03336814
47MP0003119_abnormal_digestive_system1.00759903
48MP0009046_muscle_twitch0.98611526
49MP0010234_abnormal_vibrissa_follicle0.97042511
50MP0003878_abnormal_ear_physiology0.96592261
51MP0005377_hearing/vestibular/ear_phenot0.96592261
52MP0005389_reproductive_system_phenotype0.96496527
53MP0001765_abnormal_ion_homeostasis0.95178613
54MP0008007_abnormal_cellular_replicative0.93630040
55MP0006276_abnormal_autonomic_nervous0.92497783
56MP0004142_abnormal_muscle_tone0.90278424
57MP0000569_abnormal_digit_pigmentation0.86859696
58MP0001984_abnormal_olfaction0.83768595
59MP0004381_abnormal_hair_follicle0.83050992
60MP0001664_abnormal_digestion0.81513093
61MP0001963_abnormal_hearing_physiology0.75953207
62MP0003111_abnormal_nucleus_morphology0.75046697
63MP0010368_abnormal_lymphatic_system0.69867099
64MP0000049_abnormal_middle_ear0.69766828
65MP0002095_abnormal_skin_pigmentation0.68802894
66MP0009840_abnormal_foam_cell0.68047238
67MP0003011_delayed_dark_adaptation0.66227443
68MP0001486_abnormal_startle_reflex0.64576365
69MP0003115_abnormal_respiratory_system0.63497103
70MP0000358_abnormal_cell_content/0.62833338
71MP0002233_abnormal_nose_morphology0.62504517
72MP0002735_abnormal_chemical_nociception0.62320123
73MP0001986_abnormal_taste_sensitivity0.61834903
74MP0000762_abnormal_tongue_morphology0.61195765
75MP0003699_abnormal_female_reproductive0.60893704
76MP0003195_calcinosis0.60478800
77MP0004808_abnormal_hematopoietic_stem0.60324034
78MP0009278_abnormal_bone_marrow0.60145485
79MP0005397_hematopoietic_system_phenotyp0.60135907
80MP0001545_abnormal_hematopoietic_system0.60135907
81MP0001666_abnormal_nutrient_absorption0.59226609
82MP0002229_neurodegeneration0.57605336
83MP0010307_abnormal_tumor_latency0.56786903
84MP0000026_abnormal_inner_ear0.56564191
85MP0001119_abnormal_female_reproductive0.55538613
86MP0003868_abnormal_feces_composition0.55225088
87MP0001502_abnormal_circadian_rhythm0.54025649
88MP0001293_anophthalmia0.53724258
89MP0002102_abnormal_ear_morphology0.53379881
90MP0005365_abnormal_bile_salt0.52336825
91MP0001730_embryonic_growth_arrest0.51181709
92MP0004134_abnormal_chest_morphology0.49714363
93MP0003077_abnormal_cell_cycle0.49345967
94MP0002234_abnormal_pharynx_morphology0.46962088
95MP0009745_abnormal_behavioral_response0.46291456
96MP0004957_abnormal_blastocyst_morpholog0.46162281
97MP0000015_abnormal_ear_pigmentation0.45436504
98MP0002928_abnormal_bile_duct0.45148937
99MP0002638_abnormal_pupillary_reflex0.45040705
100MP0005075_abnormal_melanosome_morpholog0.44791945
101MP0003950_abnormal_plasma_membrane0.44775579
102MP0005636_abnormal_mineral_homeostasis0.44502387
103MP0001324_abnormal_eye_pigmentation0.43976251
104MP0001919_abnormal_reproductive_system0.43926872
105MP0004036_abnormal_muscle_relaxation0.42917656
106MP0010678_abnormal_skin_adnexa0.41798696
107MP0002751_abnormal_autonomic_nervous0.41771468
108MP0002067_abnormal_sensory_capabilities0.41436186
109MP0005666_abnormal_adipose_tissue0.40795720
110MP0000350_abnormal_cell_proliferation0.38420240
111MP0005253_abnormal_eye_physiology0.37815595
112MP0000313_abnormal_cell_death0.37152507
113MP0005391_vision/eye_phenotype0.35463395
114MP0002269_muscular_atrophy0.33078314
115MP0005551_abnormal_eye_electrophysiolog0.31965358
116MP0002084_abnormal_developmental_patter0.31444509
117MP0001727_abnormal_embryo_implantation0.29978947
118MP0003861_abnormal_nervous_system0.29448515
119MP0003329_amyloid_beta_deposits0.28181326
120MP0001661_extended_life_span0.28078648
121MP0009115_abnormal_fat_cell0.27933287
122MP0003045_fibrosis0.27723761
123MP0001672_abnormal_embryogenesis/_devel0.26598091
124MP0005380_embryogenesis_phenotype0.26598091
125MP0001764_abnormal_homeostasis0.26167404
126MP0002092_abnormal_eye_morphology0.25367273
127MP0006036_abnormal_mitochondrial_physio0.24901223
128MP0002971_abnormal_brown_adipose0.24702583
129MP0004019_abnormal_vitamin_homeostasis0.23891022
130MP0002405_respiratory_system_inflammati0.22856062
131MP0001697_abnormal_embryo_size0.22768207
132MP0000534_abnormal_ureter_morphology0.22610075
133MP0003879_abnormal_hair_cell0.22302653
134MP0002152_abnormal_brain_morphology0.21478296
135MP0003936_abnormal_reproductive_system0.21233919
136MP0003984_embryonic_growth_retardation0.19999022
137MP0000427_abnormal_hair_cycle0.19736244
138MP0004197_abnormal_fetal_growth/weight/0.19390634
139MP0008961_abnormal_basal_metabolism0.19349964
140MP0002080_prenatal_lethality0.19269230
141MP0003942_abnormal_urinary_system0.19052645
142MP0002085_abnormal_embryonic_tissue0.17875403
143MP0005174_abnormal_tail_pigmentation0.17711213
144MP0003633_abnormal_nervous_system0.17568644
145MP0000432_abnormal_head_morphology0.17271348
146MP0002088_abnormal_embryonic_growth/wei0.17180310
147MP0004133_heterotaxia0.16368357
148MP0001851_eye_inflammation0.16007203
149MP0004811_abnormal_neuron_physiology0.15548808
150MP0000751_myopathy0.15410719
151MP0000604_amyloidosis0.15368762
152MP0003787_abnormal_imprinting0.15352261
153MP0006138_congestive_heart_failure0.15126965
154MP0002169_no_abnormal_phenotype0.14391723
155MP0002873_normal_phenotype0.14153541
156MP0003631_nervous_system_phenotype0.13979423
157MP0004043_abnormal_pH_regulation0.13657132
158MP0002108_abnormal_muscle_morphology0.13572380

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.32532414
2Abnormal respiratory motile cilium morphology (HP:0005938)8.80899860
3Abnormal respiratory epithelium morphology (HP:0012253)8.80899860
4Rhinitis (HP:0012384)7.89646457
5Abnormal ciliary motility (HP:0012262)7.55811133
6Chronic bronchitis (HP:0004469)7.20978599
7Infertility (HP:0000789)6.39567672
8Nasal polyposis (HP:0100582)6.36883856
9Abnormality of the nasal mucosa (HP:0000433)5.23489651
10Oligodactyly (hands) (HP:0001180)4.80442721
11Bronchiectasis (HP:0002110)4.60704580
12Facial hemangioma (HP:0000329)4.59111225
13Bronchitis (HP:0012387)4.58246800
14Nephronophthisis (HP:0000090)4.56842836
15Abdominal situs inversus (HP:0003363)4.26844829
16Abnormality of abdominal situs (HP:0011620)4.26844829
17Chromosomal breakage induced by crosslinking agents (HP:0003221)4.25612681
18Osteomalacia (HP:0002749)4.21375651
19Chromsome breakage (HP:0040012)4.15294649
20Male infertility (HP:0003251)3.86136553
21Anterior segment dysgenesis (HP:0007700)3.82854670
22Hypophosphatemic rickets (HP:0004912)3.70812607
23Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.61346274
24Abnormal spermatogenesis (HP:0008669)3.56409433
25Hypoplasia of the fovea (HP:0007750)3.56196607
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.56196607
27Abnormality of the renal medulla (HP:0100957)3.49764060
28Lip pit (HP:0100267)3.43669365
29Recurrent sinusitis (HP:0011108)3.43442904
30Gonadotropin excess (HP:0000837)3.36288391
31Abnormality of the labia minora (HP:0012880)3.34001962
32Recurrent otitis media (HP:0000403)3.33424479
33Wrist flexion contracture (HP:0001239)3.31538966
34Abnormality of the lower motor neuron (HP:0002366)3.28501747
35Oligodactyly (HP:0012165)3.21099870
36Enlarged penis (HP:0000040)3.18632998
37Tubulointerstitial nephritis (HP:0001970)3.09479261
38Abnormality of the fovea (HP:0000493)3.06090309
39Capillary hemangiomas (HP:0005306)3.03348948
40Fair hair (HP:0002286)2.95260820
41Absent septum pellucidum (HP:0001331)2.95224097
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.91637709
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.88089930
44Septo-optic dysplasia (HP:0100842)2.87030066
45Recurrent bronchitis (HP:0002837)2.83092267
46Short tibia (HP:0005736)2.82324502
47Azoospermia (HP:0000027)2.80442627
48Severe visual impairment (HP:0001141)2.70615408
49Papillary thyroid carcinoma (HP:0002895)2.66094836
50Molar tooth sign on MRI (HP:0002419)2.65087725
51Abnormality of midbrain morphology (HP:0002418)2.65087725
52Tubular atrophy (HP:0000092)2.64020299
53Attenuation of retinal blood vessels (HP:0007843)2.52968134
54Fibular hypoplasia (HP:0003038)2.52525581
55Tubulointerstitial abnormality (HP:0001969)2.52491148
56Impulsivity (HP:0100710)2.51616220
57Amyotrophic lateral sclerosis (HP:0007354)2.49765694
58Premature ovarian failure (HP:0008209)2.46980903
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46124063
60Small intestinal stenosis (HP:0012848)2.46054478
61Duodenal stenosis (HP:0100867)2.46054478
62Medial flaring of the eyebrow (HP:0010747)2.44228868
63Abnormal lung lobation (HP:0002101)2.43532698
64Truncal obesity (HP:0001956)2.43108449
65Myokymia (HP:0002411)2.40263550
66Volvulus (HP:0002580)2.38538412
67Embryonal renal neoplasm (HP:0011794)2.36352297
68Optic nerve hypoplasia (HP:0000609)2.36207553
69Abnormality of the septum pellucidum (HP:0007375)2.35379344
70Malnutrition (HP:0004395)2.32055986
71Ankle contracture (HP:0006466)2.31091444
72Conjunctival telangiectasia (HP:0000524)2.21611283
73Hyperventilation (HP:0002883)2.18170526
74Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.17119671
75Aplasia/Hypoplasia of the macula (HP:0008059)2.17117150
76Abnormality of chromosome segregation (HP:0002916)2.15536364
77Postaxial foot polydactyly (HP:0001830)2.14622990
78Congenital sensorineural hearing impairment (HP:0008527)2.11982855
79Generalized aminoaciduria (HP:0002909)2.10347054
80Gaze-evoked nystagmus (HP:0000640)2.10204972
81Pancreatic cysts (HP:0001737)2.10068071
82Bony spicule pigmentary retinopathy (HP:0007737)2.09396984
83Bicornuate uterus (HP:0000813)2.04424403
84Absent radius (HP:0003974)2.03257152
85Stage 5 chronic kidney disease (HP:0003774)2.03198260
86Abnormality of chromosome stability (HP:0003220)2.02030547
87Generalized hypopigmentation of hair (HP:0011358)2.01825246
88Methylmalonic aciduria (HP:0012120)2.01816723
89Loss of speech (HP:0002371)2.00190983
90Bundle branch block (HP:0011710)2.00043384
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5111258
92Absent/shortened dynein arms (HP:0200106)12.7090892
93Dynein arm defect of respiratory motile cilia (HP:0012255)12.7090892
94Stillbirth (HP:0003826)1.98142472
95Meckel diverticulum (HP:0002245)1.96775641
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96610026
97Aplasia/Hypoplasia affecting the retina (HP:0008061)1.96602843
98Clitoromegaly (HP:0000057)1.96065952
99Abnormality of the ileum (HP:0001549)1.94867959
100Horizontal nystagmus (HP:0000666)1.94572802
101Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93703435
102Tubulointerstitial fibrosis (HP:0005576)1.93514487
103Anhidrosis (HP:0000970)1.91113936
104Impaired proprioception (HP:0010831)1.91067825
105Aplasia involving forearm bones (HP:0009822)1.90698888
106Absent forearm bone (HP:0003953)1.90698888
107Skin pits (HP:0100276)1.90662393
108Absent frontal sinuses (HP:0002688)1.90596920
109Short ribs (HP:0000773)1.90588597
110Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89964290
111Congenital hepatic fibrosis (HP:0002612)1.89387583
112Abnormality of the duodenum (HP:0002246)1.88543094
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88402533
114Hypergonadotropic hypogonadism (HP:0000815)1.87475273
115Metaphyseal irregularity (HP:0003025)1.87411631
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85493550
117Aplastic anemia (HP:0001915)1.85253356
118Microglossia (HP:0000171)1.84667681
119Abnormality of the preputium (HP:0100587)1.83073514
120Abnormality of the renal cortex (HP:0011035)1.82751987
121Maternal diabetes (HP:0009800)1.82457908
122Apathy (HP:0000741)1.81747419
123Upper motor neuron abnormality (HP:0002127)1.81271972
124Spastic tetraparesis (HP:0001285)1.75799105
125J-shaped sella turcica (HP:0002680)1.75733044
126Renal dysplasia (HP:0000110)1.74891009
127Abnormal drinking behavior (HP:0030082)1.74309460
128Polydipsia (HP:0001959)1.74309460
129Oculomotor apraxia (HP:0000657)1.73550483
130Facial cleft (HP:0002006)1.73359599
131Heterotopia (HP:0002282)1.73026887
132Abnormality of the dental root (HP:0006486)1.69992970
133Taurodontia (HP:0000679)1.69992970
134Abnormality of permanent molar morphology (HP:0011071)1.69992970
135Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67423802
136Supernumerary spleens (HP:0009799)1.66122994
137Abnormality of dentin (HP:0010299)1.66006215
138Abnormality of the anterior horn cell (HP:0006802)1.65718212
139Degeneration of anterior horn cells (HP:0002398)1.65718212
14011 pairs of ribs (HP:0000878)1.63475044
141Abnormality of molar morphology (HP:0011070)1.58738250
142Abnormality of molar (HP:0011077)1.58738250
143Aplasia/Hypoplasia of the fibula (HP:0006492)1.58061778
144Postaxial hand polydactyly (HP:0001162)1.56403690
145Abnormality of renal excretion (HP:0011036)1.55690408
146Chronic sinusitis (HP:0011109)1.55683004
147Abnormality of the dental pulp (HP:0006479)1.53798832
148Cholecystitis (HP:0001082)1.53445921
149Abnormal gallbladder physiology (HP:0012438)1.53445921
150Median cleft lip (HP:0000161)1.52452911
151Deformed sella turcica (HP:0002681)1.52125110
152Dyschromatopsia (HP:0007641)1.52108060
153Abnormal biliary tract physiology (HP:0012439)1.51660231
154Bile duct proliferation (HP:0001408)1.51660231
155Bell-shaped thorax (HP:0001591)1.51548145
156Cystic liver disease (HP:0006706)1.51277890
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.47437194
158Absent epiphyses (HP:0010577)1.47437194
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.46401079
160Short thorax (HP:0010306)1.46384524
161Pancreatic fibrosis (HP:0100732)1.42646617
162Abnormality of ocular smooth pursuit (HP:0000617)1.34912404
163Breast carcinoma (HP:0003002)1.34532108
164Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32116235
165Congenital primary aphakia (HP:0007707)1.30342735
166Decreased central vision (HP:0007663)1.30139472
167Gait imbalance (HP:0002141)1.28534758
168Nephropathy (HP:0000112)1.28452138
169Selective tooth agenesis (HP:0001592)1.28098078
170Broad distal phalanx of finger (HP:0009836)1.25051271
171Pachygyria (HP:0001302)1.23083060
172Abnormal urine output (HP:0012590)1.21484670
173Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.20983469
174True hermaphroditism (HP:0010459)1.20029075
175Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.18876137
176Decreased motor nerve conduction velocity (HP:0003431)1.18460545
177Choroideremia (HP:0001139)1.16992857
178Aplasia/Hypoplasia of the lens (HP:0008063)1.16576308
179Nephroblastoma (Wilms tumor) (HP:0002667)1.15864187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.94509837
2PDK38.94509837
3PDK25.80083630
4TESK14.71472310
5MAP3K134.70448910
6MAP3K94.63810061
7ARAF4.13441078
8PRKD34.03371951
9LATS13.86909353
10ICK3.44225366
11ZAK2.97954050
12MOS2.55598655
13PNCK2.42854735
14PTK2B2.36074756
15LATS22.35972786
16WNK42.33756986
17BRAF2.32308753
18TAOK32.28563422
19KSR22.27100407
20STK242.20320174
21STK392.19398524
22MET2.18733520
23NEK21.86636590
24CDK91.83062352
25CDK191.74285936
26MELK1.58445563
27KSR11.51116917
28PRKCI1.49579468
29NEK91.39570589
30RAF11.33311660
31STK381.32967821
32CDK81.24893188
33FRK1.18082975
34DYRK1B1.09313718
35WNK11.07557265
36CDC71.01381033
37TYRO30.98122276
38EIF2AK30.96305236
39WEE10.95979287
40PDK10.91332568
41MAPK150.90393580
42PASK0.89867972
43STK30.83761531
44NTRK30.82048016
45MAP3K80.81583660
46NUAK10.79928704
47DYRK30.79853159
48TTK0.79175240
49CCNB10.79057409
50OXSR10.77268680
51CDK120.74831608
52NLK0.73482804
53TNIK0.71942030
54STK160.71603892
55VRK10.69319792
56BRD40.68121200
57CAMK1G0.67409001
58TGFBR10.65861504
59TNK20.65439176
60TIE10.65287311
61TRIM280.62031609
62IRAK10.61926816
63CHEK10.60429421
64CSNK1G10.59790547
65ATR0.59710010
66LMTK20.58382889
67PLK30.57867627
68CHEK20.57706708
69CSNK1A1L0.57700984
70TLK10.56019160
71MAPK130.53537692
72PKN10.52670873
73PLK20.51467002
74PINK10.46279240
75TESK20.45109422
76ATM0.44526068
77MAP2K60.43989790
78EEF2K0.43730638
79PLK40.43423565
80PRKAA20.42910301
81CSNK1G30.40512535
82MTOR0.37229092
83STK38L0.35854885
84CAMK2A0.34998664
85GRK70.34329233
86PLK10.34291272
87PDPK10.33927006
88MST40.33653037
89PTK20.32518460
90BMPR1B0.31331737
91PAK10.30722724
92CSNK1G20.27443489
93PIK3CG0.26196914
94BRSK20.25587236
95PAK20.25020610
96CDK50.25005206
97PRKACA0.24763313
98NTRK20.24439960
99EIF2AK10.24017865
100RPS6KB10.23548556
101IRAK20.23454531
102INSRR0.20942779
103PRKAA10.20476892
104MAP2K20.20029477
105RIPK40.19011535
106NEK60.18323168
107WNK30.17411092
108PRKCG0.16080221
109MAP3K100.15718228
110CAMKK10.14650758
111MAP3K40.13411701
112MARK20.12949261
113CDK10.12077689
114MUSK0.12030201
115CDK20.11784299
116ZAP700.10741848
117BRSK10.08744567
118GSK3B0.08361300
119CSNK1D0.08301577
120MARK30.08134172
121CSNK2A10.07715675
122CDK40.07532622
123PRKDC0.07135888
124PAK40.06709687
125MAPKAPK50.06380101
126CDK30.05978914
127CSNK2A20.05832863
128MAPK80.05603572
129RPS6KA10.05457677
130ACVR1B0.03643009
131STK110.03628102
132PRKCZ0.02923292
133PRKACG0.02429980
134STK100.02375647
135PRKG10.01861867
136PRKACB0.01751753
137PRKCQ0.01625435
138PDGFRB0.01398360
139BUB10.00697503
140TAOK10.00491232
141RIPK10.00434494
142EGFR0.00347906
143MAPK10.00298260
144CDK6-0.0216852
145AURKB-0.0201756
146CSNK1E-0.0173975
147CDK7-0.0097476
148PIM1-0.0095353
149RPS6KA3-0.0082365
150PRKCB-0.0065990
151MAPK10-0.0051396
152CDK15-0.0034116
153AURKA-0.0033098
154MAP2K7-0.0014602

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.51671241
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.20200121
3Pyruvate metabolism_Homo sapiens_hsa006204.06851369
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.81717643
5Fatty acid biosynthesis_Homo sapiens_hsa000613.34788875
6Mismatch repair_Homo sapiens_hsa034303.16407497
7Basal transcription factors_Homo sapiens_hsa030223.15632713
8Ovarian steroidogenesis_Homo sapiens_hsa049133.14084075
9Propanoate metabolism_Homo sapiens_hsa006403.01856255
10Dorso-ventral axis formation_Homo sapiens_hsa043202.95054230
11Glucagon signaling pathway_Homo sapiens_hsa049222.76123120
12Phototransduction_Homo sapiens_hsa047442.63315835
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60843032
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.58093059
15Fanconi anemia pathway_Homo sapiens_hsa034602.55946975
16Selenocompound metabolism_Homo sapiens_hsa004502.55560293
17Linoleic acid metabolism_Homo sapiens_hsa005912.50117435
18Pentose phosphate pathway_Homo sapiens_hsa000302.43828893
19Caffeine metabolism_Homo sapiens_hsa002322.39134052
20Olfactory transduction_Homo sapiens_hsa047402.25243444
21Oocyte meiosis_Homo sapiens_hsa041142.15518601
22Nucleotide excision repair_Homo sapiens_hsa034202.06454663
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03709584
24Glycerolipid metabolism_Homo sapiens_hsa005611.97457078
25Nicotine addiction_Homo sapiens_hsa050331.91262568
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88167176
27RNA transport_Homo sapiens_hsa030131.73416121
28mRNA surveillance pathway_Homo sapiens_hsa030151.72458094
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.72141853
30Huntingtons disease_Homo sapiens_hsa050161.66523341
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63630802
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54022844
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.53682273
34PPAR signaling pathway_Homo sapiens_hsa033201.50870716
35Circadian rhythm_Homo sapiens_hsa047101.49655400
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.48937090
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.39604464
38Amphetamine addiction_Homo sapiens_hsa050311.38922514
39p53 signaling pathway_Homo sapiens_hsa041151.35838420
40Gap junction_Homo sapiens_hsa045401.35294881
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35290501
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33571208
43Carbon metabolism_Homo sapiens_hsa012001.31904803
44Antigen processing and presentation_Homo sapiens_hsa046121.28913148
45Morphine addiction_Homo sapiens_hsa050321.28562745
46Fructose and mannose metabolism_Homo sapiens_hsa000511.24157989
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20685944
48Renin secretion_Homo sapiens_hsa049241.17141027
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15388031
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11331389
51Fat digestion and absorption_Homo sapiens_hsa049751.10751965
52Purine metabolism_Homo sapiens_hsa002301.10367532
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07354370
54Ether lipid metabolism_Homo sapiens_hsa005651.07301992
55Cardiac muscle contraction_Homo sapiens_hsa042601.05805727
56GABAergic synapse_Homo sapiens_hsa047271.01227111
57Mineral absorption_Homo sapiens_hsa049780.99835753
58Biosynthesis of amino acids_Homo sapiens_hsa012300.97456844
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.93044531
60Fatty acid metabolism_Homo sapiens_hsa012120.93036094
61Folate biosynthesis_Homo sapiens_hsa007900.90354758
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89084337
63Fatty acid degradation_Homo sapiens_hsa000710.88323601
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84734425
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81694291
66Sphingolipid metabolism_Homo sapiens_hsa006000.79737052
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75227294
68ABC transporters_Homo sapiens_hsa020100.74287468
69Long-term potentiation_Homo sapiens_hsa047200.73641860
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72414146
71TGF-beta signaling pathway_Homo sapiens_hsa043500.71065934
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.70083448
73Homologous recombination_Homo sapiens_hsa034400.69623960
74Sulfur relay system_Homo sapiens_hsa041220.69525055
75Glutathione metabolism_Homo sapiens_hsa004800.68401614
76Synaptic vesicle cycle_Homo sapiens_hsa047210.67445637
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67119509
78Thyroid cancer_Homo sapiens_hsa052160.66859478
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64083832
80Estrogen signaling pathway_Homo sapiens_hsa049150.63103912
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62458946
82RNA degradation_Homo sapiens_hsa030180.61510867
83Cell cycle_Homo sapiens_hsa041100.60108917
84Renin-angiotensin system_Homo sapiens_hsa046140.59371802
85Systemic lupus erythematosus_Homo sapiens_hsa053220.58845460
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58680876
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58677496
88Hedgehog signaling pathway_Homo sapiens_hsa043400.57747163
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57409220
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57366610
91Legionellosis_Homo sapiens_hsa051340.55766926
92Chemical carcinogenesis_Homo sapiens_hsa052040.53903890
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53130179
94Serotonergic synapse_Homo sapiens_hsa047260.52459632
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52373475
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.52001032
97RNA polymerase_Homo sapiens_hsa030200.51544399
98Arachidonic acid metabolism_Homo sapiens_hsa005900.50869255
99Calcium signaling pathway_Homo sapiens_hsa040200.47802915
100Vitamin digestion and absorption_Homo sapiens_hsa049770.46569594
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.46006988
102Butanoate metabolism_Homo sapiens_hsa006500.45390925
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44884301
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44170199
105VEGF signaling pathway_Homo sapiens_hsa043700.43856811
106AMPK signaling pathway_Homo sapiens_hsa041520.43106157
107Inositol phosphate metabolism_Homo sapiens_hsa005620.42724482
108Pyrimidine metabolism_Homo sapiens_hsa002400.40287711
109Endocytosis_Homo sapiens_hsa041440.39013390
110Thyroid hormone synthesis_Homo sapiens_hsa049180.38044543
111Phenylalanine metabolism_Homo sapiens_hsa003600.37933308
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37915361
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36677496
114Glutamatergic synapse_Homo sapiens_hsa047240.36485952
115N-Glycan biosynthesis_Homo sapiens_hsa005100.34599998
116Bile secretion_Homo sapiens_hsa049760.33605698
117Insulin secretion_Homo sapiens_hsa049110.32969337
118Viral carcinogenesis_Homo sapiens_hsa052030.31280749
119Adherens junction_Homo sapiens_hsa045200.30252969
120Spliceosome_Homo sapiens_hsa030400.30084723
121Metabolic pathways_Homo sapiens_hsa011000.29281563
122Retinol metabolism_Homo sapiens_hsa008300.29062549
123Taste transduction_Homo sapiens_hsa047420.28889234
124FoxO signaling pathway_Homo sapiens_hsa040680.28224559
125Collecting duct acid secretion_Homo sapiens_hsa049660.26936460
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26598983
127Protein digestion and absorption_Homo sapiens_hsa049740.26039775
128Arginine and proline metabolism_Homo sapiens_hsa003300.24043639
129Epstein-Barr virus infection_Homo sapiens_hsa051690.23698496
130Regulation of autophagy_Homo sapiens_hsa041400.21993455
131Wnt signaling pathway_Homo sapiens_hsa043100.20899048
132Pancreatic secretion_Homo sapiens_hsa049720.20793114
133Alcoholism_Homo sapiens_hsa050340.20736119
134Lysine degradation_Homo sapiens_hsa003100.20466987
135Long-term depression_Homo sapiens_hsa047300.19917024
136Circadian entrainment_Homo sapiens_hsa047130.19870689
137Influenza A_Homo sapiens_hsa051640.19374167
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.19079570
139B cell receptor signaling pathway_Homo sapiens_hsa046620.17892028
140DNA replication_Homo sapiens_hsa030300.17338929
141cAMP signaling pathway_Homo sapiens_hsa040240.17062307
142Nitrogen metabolism_Homo sapiens_hsa009100.16064262
143T cell receptor signaling pathway_Homo sapiens_hsa046600.15181619
144Salmonella infection_Homo sapiens_hsa051320.15053606
145Non-homologous end-joining_Homo sapiens_hsa034500.14041939
146MAPK signaling pathway_Homo sapiens_hsa040100.14027094
147mTOR signaling pathway_Homo sapiens_hsa041500.13493239
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12398767
149Base excision repair_Homo sapiens_hsa034100.11844753
150HTLV-I infection_Homo sapiens_hsa051660.11698189
151Cholinergic synapse_Homo sapiens_hsa047250.11460369
152Hippo signaling pathway_Homo sapiens_hsa043900.10383988
153MicroRNAs in cancer_Homo sapiens_hsa052060.10302092
154Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09906643
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07561495
156Oxytocin signaling pathway_Homo sapiens_hsa049210.05944813
157Ras signaling pathway_Homo sapiens_hsa040140.05517756
158Fatty acid elongation_Homo sapiens_hsa000620.03457727
159Tight junction_Homo sapiens_hsa045300.02945723

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