ADAD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)7.92603639
2DNA methylation involved in gamete generation (GO:0043046)7.86830663
3synaptonemal complex assembly (GO:0007130)7.74194910
4synaptonemal complex organization (GO:0070193)7.73266218
5cilium or flagellum-dependent cell motility (GO:0001539)6.31877632
6regulation of meiosis I (GO:0060631)6.08761508
7fusion of sperm to egg plasma membrane (GO:0007342)6.08168865
8positive regulation of catecholamine secretion (GO:0033605)5.95181222
9regulation of phosphoprotein phosphatase activity (GO:0043666)5.89742201
10male meiosis I (GO:0007141)5.73819429
11meiotic nuclear division (GO:0007126)5.70277630
12binding of sperm to zona pellucida (GO:0007339)5.68579270
13sperm-egg recognition (GO:0035036)5.63804909
14chromosome organization involved in meiosis (GO:0070192)5.63698596
15sperm motility (GO:0030317)5.40997472
16spermatid development (GO:0007286)5.35763231
17gene silencing by RNA (GO:0031047)5.10126425
18axonemal dynein complex assembly (GO:0070286)5.09232122
19cell-cell recognition (GO:0009988)4.96977506
20meiosis I (GO:0007127)4.92118727
21regulation of acrosome reaction (GO:0060046)4.82426477
22motile cilium assembly (GO:0044458)4.62645462
23multicellular organism reproduction (GO:0032504)4.62645243
24DNA double-strand break processing (GO:0000729)4.46676653
25nuclear pore complex assembly (GO:0051292)4.45468499
26epithelial cilium movement (GO:0003351)4.44403743
27plasma membrane fusion (GO:0045026)4.42730488
28nuclear pore organization (GO:0006999)4.40295627
29meiotic cell cycle (GO:0051321)4.36908199
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.33066155
31DNA replication-dependent nucleosome organization (GO:0034723)4.27568991
32DNA replication-dependent nucleosome assembly (GO:0006335)4.27568991
33acrosome assembly (GO:0001675)4.25680841
34meiotic cell cycle process (GO:1903046)4.25664804
35tryptophan catabolic process (GO:0006569)4.24832299
36indole-containing compound catabolic process (GO:0042436)4.24832299
37indolalkylamine catabolic process (GO:0046218)4.24832299
38potassium ion export (GO:0071435)4.19851119
39DNA alkylation (GO:0006305)4.10223233
40DNA methylation (GO:0006306)4.10223233
41activation of protein kinase B activity (GO:0032148)4.03008779
42acrosome reaction (GO:0007340)4.00347061
43germ cell development (GO:0007281)3.99823973
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.99719929
45regulation of cilium movement (GO:0003352)3.99531386
46relaxation of smooth muscle (GO:0044557)3.98003514
47regulation of posttranscriptional gene silencing (GO:0060147)3.91184359
48regulation of gene silencing by miRNA (GO:0060964)3.91184359
49regulation of gene silencing by RNA (GO:0060966)3.91184359
50heterochromatin organization (GO:0070828)3.84904700
51gene silencing (GO:0016458)3.82681370
52regulation of histone H3-K9 methylation (GO:0051570)3.79972441
53spermatogenesis (GO:0007283)3.75445139
54male gamete generation (GO:0048232)3.75344223
55reproduction (GO:0000003)3.75009551
56chaperone-mediated protein complex assembly (GO:0051131)3.73231604
57coenzyme catabolic process (GO:0009109)3.68962333
58cilium movement (GO:0003341)3.68030836
59microtubule depolymerization (GO:0007019)3.66302175
60mitotic nuclear envelope disassembly (GO:0007077)3.64412069
61fertilization (GO:0009566)3.63662942
62single strand break repair (GO:0000012)3.59015491
63regulation of oxidative stress-induced neuron death (GO:1903203)3.58801972
64protein K6-linked ubiquitination (GO:0085020)3.57285206
65cell wall macromolecule metabolic process (GO:0044036)3.55424149
66cell wall macromolecule catabolic process (GO:0016998)3.55424149
67retinal cone cell development (GO:0046549)3.51804531
68gamete generation (GO:0007276)3.50744041
69cellular process involved in reproduction in multicellular organism (GO:0022412)3.46246073
70membrane disassembly (GO:0030397)3.45672937
71nuclear envelope disassembly (GO:0051081)3.45672937
72negative regulation of inclusion body assembly (GO:0090084)3.43182380
73organic cation transport (GO:0015695)3.42102095
74pore complex assembly (GO:0046931)3.41967069
75protein localization to chromosome, centromeric region (GO:0071459)3.37914789
76mitotic sister chromatid segregation (GO:0000070)3.37830423
77oogenesis (GO:0048477)3.37581351
78DNA methylation or demethylation (GO:0044728)3.37083564
79oocyte development (GO:0048599)3.36809786
80regulation of centriole replication (GO:0046599)3.36641163
81positive regulation of meiotic cell cycle (GO:0051446)3.36554665
82chromosome condensation (GO:0030261)3.35980802
83negative regulation of meiosis (GO:0045835)3.34291456
84histone exchange (GO:0043486)3.33812118
85DNA packaging (GO:0006323)3.32468689
86synapsis (GO:0007129)3.27870580
87positive regulation of glycolytic process (GO:0045821)3.26862968
88mitochondrion degradation (GO:0000422)3.26790745
89tryptophan metabolic process (GO:0006568)3.25464222
90calcium ion-dependent exocytosis (GO:0017156)3.24414759
91DNA replication initiation (GO:0006270)3.24186219
92histone H3-K36 demethylation (GO:0070544)3.23383438
93regulation of centrosome cycle (GO:0046605)3.22762240
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22475323
95histone H3-K9 demethylation (GO:0033169)3.21584765
96single fertilization (GO:0007338)3.20316935
97regulation of female gonad development (GO:2000194)3.19726899
98positive regulation of meiosis (GO:0045836)3.19495232
99indolalkylamine metabolic process (GO:0006586)3.17706681
100aspartate family amino acid catabolic process (GO:0009068)3.16326227
101regulation of inclusion body assembly (GO:0090083)3.13930418
102mitotic chromosome condensation (GO:0007076)3.13681304
103meiotic chromosome segregation (GO:0045132)3.12981580
104mitotic sister chromatid cohesion (GO:0007064)3.11375533
105mitotic metaphase plate congression (GO:0007080)3.09835494
106regulation of chromosome segregation (GO:0051983)3.09804159
107male sex determination (GO:0030238)3.08342318
108reciprocal meiotic recombination (GO:0007131)3.06958579
109reciprocal DNA recombination (GO:0035825)3.06958579
110DNA modification (GO:0006304)3.06002855
111sex differentiation (GO:0007548)3.03042489
112somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00299453
113somatic hypermutation of immunoglobulin genes (GO:0016446)3.00299453
114sister chromatid cohesion (GO:0007062)3.00107712
115DNA strand elongation involved in DNA replication (GO:0006271)2.97501860
116protein polyglutamylation (GO:0018095)2.97186827
117cellular biogenic amine catabolic process (GO:0042402)2.97040206
118amine catabolic process (GO:0009310)2.97040206
119protein localization to kinetochore (GO:0034501)2.95594434
120regulation of spindle checkpoint (GO:0090231)2.94970572
121protein K11-linked deubiquitination (GO:0035871)2.94445644
122chromosome organization (GO:0051276)2.93029270
123translesion synthesis (GO:0019985)2.92214154
124formation of translation preinitiation complex (GO:0001731)2.92063104
125positive regulation of chromosome segregation (GO:0051984)2.91929590
126photoreceptor cell maintenance (GO:0045494)2.91769502
127regulation of oxidative phosphorylation (GO:0002082)2.89920640
128protein complex localization (GO:0031503)2.88975190
129negative regulation of chromosome segregation (GO:0051985)2.87836852
130positive regulation of amine transport (GO:0051954)2.87139120
131histone H2A acetylation (GO:0043968)2.86961539
132sister chromatid segregation (GO:0000819)2.85239558
133behavioral response to nicotine (GO:0035095)2.83698319
134attachment of spindle microtubules to kinetochore (GO:0008608)2.81637434
135female gamete generation (GO:0007292)2.80481088
136negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.78194160
137intraciliary transport (GO:0042073)2.77925246
138platelet dense granule organization (GO:0060155)2.75166332
139regulation of dopamine secretion (GO:0014059)2.74722007
140negative regulation of amino acid transport (GO:0051956)2.74479716
141regulation of autophagic vacuole assembly (GO:2000785)2.73676650
142DNA catabolic process, exonucleolytic (GO:0000738)2.70431129
143regulation of hydrogen peroxide-induced cell death (GO:1903205)2.70413015
144polyamine biosynthetic process (GO:0006596)2.69638928
145regulation of chronic inflammatory response (GO:0002676)2.66402393
146cilium morphogenesis (GO:0060271)2.66023158
147negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.60157028
148tongue development (GO:0043586)2.53176251
149protein targeting to Golgi (GO:0000042)2.52424012
150DNA synthesis involved in DNA repair (GO:0000731)2.52348618
151negative regulation of telomere maintenance (GO:0032205)2.51606042
152axoneme assembly (GO:0035082)2.51259408
153resolution of meiotic recombination intermediates (GO:0000712)2.51204790
154establishment of protein localization to Golgi (GO:0072600)2.48948245
155inositol phosphate catabolic process (GO:0071545)2.48926218
156regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.46484919
157negative regulation of response to reactive oxygen species (GO:1901032)2.45445051
158Leydig cell differentiation (GO:0033327)2.44404735
159piRNA metabolic process (GO:0034587)10.8601298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.65987453
2E2F7_22180533_ChIP-Seq_HELA_Human6.09014521
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.82983969
4IGF1R_20145208_ChIP-Seq_DFB_Human4.55619063
5EZH2_22144423_ChIP-Seq_EOC_Human4.33869152
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.16194007
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.90159578
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.89258933
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.17114355
10ZNF274_21170338_ChIP-Seq_K562_Hela3.08748932
11VDR_22108803_ChIP-Seq_LS180_Human2.89370601
12GBX2_23144817_ChIP-Seq_PC3_Human2.83451934
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75939459
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73342925
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55086214
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.50720170
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.50720170
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.50720170
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.44261371
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.38397879
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31082886
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23966732
23ER_23166858_ChIP-Seq_MCF-7_Human2.21244208
24FUS_26573619_Chip-Seq_HEK293_Human2.11572379
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09793583
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09200674
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09061546
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06089077
29ESR1_20079471_ChIP-ChIP_T-47D_Human2.04612022
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01492870
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01189509
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99175597
33P300_19829295_ChIP-Seq_ESCs_Human1.98089536
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96667585
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.96644563
36BCAT_22108803_ChIP-Seq_LS180_Human1.90199972
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.88557672
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.88272968
39CBP_20019798_ChIP-Seq_JUKART_Human1.86611476
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.86611476
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85033831
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84607874
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82215479
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.80741574
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80741574
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78671565
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.77427257
48AR_21909140_ChIP-Seq_LNCAP_Human1.77089955
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75110503
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74704609
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74437608
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.74184278
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72731403
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70485692
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.69000727
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67351059
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63812646
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63328514
59XRN2_22483619_ChIP-Seq_HELA_Human1.63327544
60AR_25329375_ChIP-Seq_VCAP_Human1.60789963
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.60699204
62SMAD4_21799915_ChIP-Seq_A2780_Human1.59196375
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58955093
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.58656000
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57948917
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.57607761
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.57475992
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.57464964
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56021965
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55744756
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.55222543
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53898692
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.53347364
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.52427209
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51994054
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.50420299
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49721823
78RUNX2_22187159_ChIP-Seq_PCA_Human1.48176495
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.45810866
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.45575232
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45240190
82NANOG_19829295_ChIP-Seq_ESCs_Human1.44872223
83SOX2_19829295_ChIP-Seq_ESCs_Human1.44872223
84EWS_26573619_Chip-Seq_HEK293_Human1.44508968
85GABP_19822575_ChIP-Seq_HepG2_Human1.43951402
86STAT3_23295773_ChIP-Seq_U87_Human1.43573772
87NANOG_20526341_ChIP-Seq_ESCs_Human1.40236867
88MYC_19829295_ChIP-Seq_ESCs_Human1.36544471
89DCP1A_22483619_ChIP-Seq_HELA_Human1.35400544
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35182732
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32842888
92VDR_23849224_ChIP-Seq_CD4+_Human1.30983973
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29983455
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29580252
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28850412
96TCF4_23295773_ChIP-Seq_U87_Human1.28764911
97KDM5A_27292631_Chip-Seq_BREAST_Human1.27910889
98HOXB7_26014856_ChIP-Seq_BT474_Human1.26891242
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26867996
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25134103
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25042712
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25040465
103HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24772478
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.24428151
105CDX2_22108803_ChIP-Seq_LS180_Human1.23238249
106AHR_22903824_ChIP-Seq_MCF-7_Human1.23232574
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.23224970
108TTF2_22483619_ChIP-Seq_HELA_Human1.22726164
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21598737
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21072259
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20806898
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.20167939
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.19691189
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19602806
115GABP_17652178_ChIP-ChIP_JURKAT_Human1.19379561
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18830282
117OCT4_20526341_ChIP-Seq_ESCs_Human1.18711560
118RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17744492
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17558028
120AR_21572438_ChIP-Seq_LNCaP_Human1.17422769
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17390194
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17287130
123* TCF4_22108803_ChIP-Seq_LS180_Human1.17060938
124POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16806147
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16761878
126GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.16393871
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16248576
128FOXH1_21741376_ChIP-Seq_EPCs_Human1.15116427
129TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15113836
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14950106
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14704087
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14258594
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13654661
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13249642
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12805028
136PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12552211
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11033055
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10774358
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10667148
140ERA_21632823_ChIP-Seq_H3396_Human1.10335406
141TP53_22573176_ChIP-Seq_HFKS_Human1.09972642
142FOXP3_21729870_ChIP-Seq_TREG_Human1.09771714
143TP53_18474530_ChIP-ChIP_U2OS_Human1.09565404
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08408199
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08363616
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07736837
147SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07601895
148POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07566990
149OCT1_27270436_Chip-Seq_PROSTATE_Human1.07368767
150WDR5_24793694_ChIP-Seq_LNCAP_Human1.07250408
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06517388
152NCOR_22424771_ChIP-Seq_293T_Human1.06486375
153RAC3_21632823_ChIP-Seq_H3396_Human1.05804139
154IRF8_22096565_ChIP-ChIP_GC-B_Human1.05635207
155NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03938209
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03515277
157TBL1_22424771_ChIP-Seq_293T_Human1.02880056
158TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02541867
159TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01635310
160MYC_18940864_ChIP-ChIP_HL60_Human1.01396410
161TAF15_26573619_Chip-Seq_HEK293_Human1.00752879
162AR_20517297_ChIP-Seq_VCAP_Human1.00485960
163GATA3_26560356_Chip-Seq_TH1_Human1.00315729
164NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98064126
165YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97996457
166ERG_20517297_ChIP-Seq_VCAP_Human0.97990966
167TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97518639
168EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97276905
169FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96470849
170TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96070056
171NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95971765
172HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95101702
173RXR_22108803_ChIP-Seq_LS180_Human0.93721686
174PHF8_20622853_ChIP-Seq_HELA_Human0.93597207
175GATA3_26560356_Chip-Seq_TH2_Human0.93388416
176ZNF263_19887448_ChIP-Seq_K562_Human0.93328226
177E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92174256
178PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91538379
179PHF8_20622854_ChIP-Seq_HELA_Human0.91212098
180FOXA1_25329375_ChIP-Seq_VCAP_Human0.90561585
181FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90561585
182NANOG_18692474_ChIP-Seq_MESCs_Mouse0.90379415
183* KAP1_27257070_Chip-Seq_ESCs_Mouse0.90022598
184TAL1_26923725_Chip-Seq_HPCs_Mouse0.89752968
185CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89672358
186* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88962381
187ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88399244
188NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87995519
189PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87678885
190SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86736141
191SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86485631
192SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85152515
193NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84679521
194CIITA_25753668_ChIP-Seq_RAJI_Human0.84607547
195BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83721155
196SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83679975
197TET1_21451524_ChIP-Seq_MESCs_Mouse0.81754689
198SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80873431
199FOXP1_21924763_ChIP-Seq_HESCs_Human0.79306220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.94119488
2MP0005410_abnormal_fertilization6.65451600
3MP0008057_abnormal_DNA_replication4.35036398
4MP0008004_abnormal_stomach_pH4.25767294
5MP0001929_abnormal_gametogenesis4.02790964
6MP0010094_abnormal_chromosome_stability3.96770231
7MP0003698_abnormal_male_reproductive3.68315112
8MP0003111_abnormal_nucleus_morphology3.63893354
9MP0002210_abnormal_sex_determination3.63477264
10MP0003693_abnormal_embryo_hatching3.31216234
11MP0004957_abnormal_blastocyst_morpholog3.20805323
12MP0001145_abnormal_male_reproductive3.08675162
13MP0008058_abnormal_DNA_repair3.03222856
14MP0002254_reproductive_system_inflammat2.97380525
15MP0002653_abnormal_ependyma_morphology2.93730515
16MP0003077_abnormal_cell_cycle2.82595777
17MP0001501_abnormal_sleep_pattern2.78805414
18MP0000653_abnormal_sex_gland2.69961033
19MP0003786_premature_aging2.58236362
20MP0008995_early_reproductive_senescence2.39396453
21MP0001984_abnormal_olfaction2.36887035
22MP0002161_abnormal_fertility/fecundity2.28436637
23MP0010386_abnormal_urinary_bladder2.18711461
24MP0001730_embryonic_growth_arrest2.08909773
25MP0005167_abnormal_blood-brain_barrier1.98693891
26MP0008007_abnormal_cellular_replicative1.94176735
27MP0003718_maternal_effect1.91892698
28MP0008932_abnormal_embryonic_tissue1.89731936
29MP0005253_abnormal_eye_physiology1.88483798
30MP0005551_abnormal_eye_electrophysiolog1.82502046
31MP0002102_abnormal_ear_morphology1.78723039
32MP0010352_gastrointestinal_tract_polyps1.78336650
33MP0005058_abnormal_lysosome_morphology1.69138858
34MP0003195_calcinosis1.69123254
35MP0001764_abnormal_homeostasis1.68122251
36MP0002160_abnormal_reproductive_system1.64040414
37MP0005646_abnormal_pituitary_gland1.62077506
38MP0000350_abnormal_cell_proliferation1.60416100
39MP0004133_heterotaxia1.58364310
40MP0005360_urolithiasis1.54377453
41MP0005377_hearing/vestibular/ear_phenot1.52869521
42MP0003878_abnormal_ear_physiology1.52869521
43MP0005380_embryogenesis_phenotype1.52348429
44MP0001672_abnormal_embryogenesis/_devel1.52348429
45MP0001664_abnormal_digestion1.51360317
46MP0002084_abnormal_developmental_patter1.49971753
47MP0010307_abnormal_tumor_latency1.48349072
48MP0005499_abnormal_olfactory_system1.46080116
49MP0005394_taste/olfaction_phenotype1.46080116
50MP0001697_abnormal_embryo_size1.45943925
51MP0003123_paternal_imprinting1.45577537
52MP0002085_abnormal_embryonic_tissue1.44427916
53MP0003646_muscle_fatigue1.40642680
54MP0003890_abnormal_embryonic-extraembry1.40380134
55MP0009745_abnormal_behavioral_response1.39998706
56MP0003011_delayed_dark_adaptation1.39726103
57MP0002138_abnormal_hepatobiliary_system1.38424545
58MP0006036_abnormal_mitochondrial_physio1.36966512
59MP0001968_abnormal_touch/_nociception1.36098420
60MP0004233_abnormal_muscle_weight1.31149826
61MP0004197_abnormal_fetal_growth/weight/1.26921888
62MP0006035_abnormal_mitochondrial_morpho1.26423047
63MP0008789_abnormal_olfactory_epithelium1.25628646
64MP0003984_embryonic_growth_retardation1.24334336
65MP0002148_abnormal_hypersensitivity_rea1.23889853
66MP0002080_prenatal_lethality1.23817968
67MP0001905_abnormal_dopamine_level1.22239127
68MP0009046_muscle_twitch1.20757027
69MP0002088_abnormal_embryonic_growth/wei1.20590078
70MP0001293_anophthalmia1.20421621
71MP0009278_abnormal_bone_marrow1.17407122
72MP0009764_decreased_sensitivity_to1.14946810
73MP0002086_abnormal_extraembryonic_tissu1.14414662
74MP0003119_abnormal_digestive_system1.14208282
75MP0001119_abnormal_female_reproductive1.14052040
76MP0002638_abnormal_pupillary_reflex1.12804697
77MP0001188_hyperpigmentation1.11655932
78MP0002272_abnormal_nervous_system1.11460321
79MP0000427_abnormal_hair_cycle1.08250575
80MP0009785_altered_susceptibility_to1.07985619
81MP0003045_fibrosis1.07885127
82MP0000313_abnormal_cell_death1.06364764
83MP0003699_abnormal_female_reproductive1.05639030
84MP0005389_reproductive_system_phenotype1.04785487
85MP0003724_increased_susceptibility_to1.03813139
86MP0003315_abnormal_perineum_morphology1.03563657
87MP0002837_dystrophic_cardiac_calcinosis1.03337571
88MP0005670_abnormal_white_adipose1.03059560
89MP0005310_abnormal_salivary_gland1.02464869
90MP0003880_abnormal_central_pattern1.01922516
91MP0002736_abnormal_nociception_after1.01761405
92MP0004043_abnormal_pH_regulation1.01019272
93MP0010368_abnormal_lymphatic_system1.00061365
94MP0000538_abnormal_urinary_bladder0.98651150
95MP0000465_gastrointestinal_hemorrhage0.97874429
96MP0003303_peritoneal_inflammation0.97553923
97MP0002735_abnormal_chemical_nociception0.96157031
98MP0005076_abnormal_cell_differentiation0.95039818
99MP0000358_abnormal_cell_content/0.92609600
100MP0010234_abnormal_vibrissa_follicle0.91966547
101MP0001502_abnormal_circadian_rhythm0.91709787
102MP0005623_abnormal_meninges_morphology0.91690150
103MP0000631_abnormal_neuroendocrine_gland0.91018629
104MP0000516_abnormal_urinary_system0.89486093
105MP0005367_renal/urinary_system_phenotyp0.89486093
106MP0000230_abnormal_systemic_arterial0.88793423
107MP0002064_seizures0.87342167
108MP0003283_abnormal_digestive_organ0.86863421
109MP0006082_CNS_inflammation0.86660618
110MP0002019_abnormal_tumor_incidence0.86293499
111MP0001486_abnormal_startle_reflex0.84992478
112MP0009697_abnormal_copulation0.83802488
113MP0005647_abnormal_sex_gland0.83247608
114MP0003941_abnormal_skin_development0.82620284
115MP0000537_abnormal_urethra_morphology0.81913543
116MP0002332_abnormal_exercise_endurance0.81803837
117MP0001545_abnormal_hematopoietic_system0.80492394
118MP0005397_hematopoietic_system_phenotyp0.80492394
119MP0002282_abnormal_trachea_morphology0.79696833
120MP0003936_abnormal_reproductive_system0.78984762
121MP0002132_abnormal_respiratory_system0.77695948
122MP0003806_abnormal_nucleotide_metabolis0.77690864
123MP0006276_abnormal_autonomic_nervous0.77386095
124MP0005084_abnormal_gallbladder_morpholo0.77191335
125MP0001727_abnormal_embryo_implantation0.76921880
126MP0002572_abnormal_emotion/affect_behav0.76739971
127MP0005395_other_phenotype0.76641935
128MP0001986_abnormal_taste_sensitivity0.76104728
129MP0004215_abnormal_myocardial_fiber0.75717847
130MP0010678_abnormal_skin_adnexa0.75451761
131MP0005187_abnormal_penis_morphology0.74225439
132MP0002269_muscular_atrophy0.73508102
133MP0002090_abnormal_vision0.72325334
134MP0002139_abnormal_hepatobiliary_system0.70814991
135MP0001661_extended_life_span0.70063602
136MP0001849_ear_inflammation0.69891355
137MP0000343_altered_response_to0.69514738
138MP0004484_altered_response_of0.69437504
139MP0002876_abnormal_thyroid_physiology0.68038658
140MP0004885_abnormal_endolymph0.67733810
141MP0003115_abnormal_respiratory_system0.67363692
142MP0003861_abnormal_nervous_system0.67075867
143MP0003635_abnormal_synaptic_transmissio0.64920694
144MP0005174_abnormal_tail_pigmentation0.63326877
145MP0003121_genomic_imprinting0.62328770
146MP0009672_abnormal_birth_weight0.60472270
147MP0003633_abnormal_nervous_system0.60360757
148MP0009703_decreased_birth_body0.59970957
149MP0005386_behavior/neurological_phenoty0.58913681
150MP0004924_abnormal_behavior0.58913681
151MP0000490_abnormal_crypts_of0.58540452
152MP0002092_abnormal_eye_morphology0.58184942
153MP0004264_abnormal_extraembryonic_tissu0.57438742
154MP0003567_abnormal_fetal_cardiomyocyte0.55290924
155MP0005384_cellular_phenotype0.53875520
156MP0010030_abnormal_orbit_morphology0.52026016
157MP0005266_abnormal_metabolism0.51777741
158MP0003136_yellow_coat_color0.51372799
159MP0006072_abnormal_retinal_apoptosis0.50463819
160MP0005621_abnormal_cell_physiology0.50100040
161MP0001915_intracranial_hemorrhage0.50050815
162MP0000432_abnormal_head_morphology0.49925808
163MP0004808_abnormal_hematopoietic_stem0.48339266
164MP0001919_abnormal_reproductive_system0.46867169
165MP0002697_abnormal_eye_size0.46693800
166MP0003937_abnormal_limbs/digits/tail_de0.45733424
167MP0002111_abnormal_tail_morphology0.44772579
168MP0003950_abnormal_plasma_membrane0.43691030
169MP0005391_vision/eye_phenotype0.42556536
170MP0008260_abnormal_autophagy0.41541390
171MP0002114_abnormal_axial_skeleton0.38964629
172MP0002796_impaired_skin_barrier0.38749820
173MP0009053_abnormal_anal_canal0.37157821
174MP0005666_abnormal_adipose_tissue0.36711381
175MP0005501_abnormal_skin_physiology0.36509912

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.95603344
2Absent/shortened dynein arms (HP:0200106)7.12621617
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.12621617
4Abnormal respiratory epithelium morphology (HP:0012253)5.33876016
5Abnormal respiratory motile cilium morphology (HP:0005938)5.33876016
6Abnormal respiratory motile cilium physiology (HP:0012261)5.17953525
7Abnormality of the lower motor neuron (HP:0002366)4.77960960
8Infertility (HP:0000789)4.76717970
9Rhinitis (HP:0012384)4.69377965
10Chronic bronchitis (HP:0004469)4.68011318
11Hypoplasia of the uterus (HP:0000013)4.34304328
12Male infertility (HP:0003251)4.30571533
13Gonadotropin excess (HP:0000837)4.07442462
14Selective tooth agenesis (HP:0001592)4.06362028
15Type II lissencephaly (HP:0007260)3.88071119
16Abnormal spermatogenesis (HP:0008669)3.87045534
17Impulsivity (HP:0100710)3.81711187
18Abnormal ciliary motility (HP:0012262)3.76484653
19Aplasia/hypoplasia of the uterus (HP:0008684)3.76026518
20Degeneration of anterior horn cells (HP:0002398)3.58781675
21Abnormality of the anterior horn cell (HP:0006802)3.58781675
22Nasal polyposis (HP:0100582)3.50565140
23Azoospermia (HP:0000027)3.48759730
24Supernumerary spleens (HP:0009799)3.40461786
25Amyotrophic lateral sclerosis (HP:0007354)3.37576976
26Inability to walk (HP:0002540)3.23144158
27Ependymoma (HP:0002888)3.17731909
28Male pseudohermaphroditism (HP:0000037)3.16113953
29Nephronophthisis (HP:0000090)3.14829580
30Retinal dysplasia (HP:0007973)3.12678132
3111 pairs of ribs (HP:0000878)3.12142934
32Chronic hepatic failure (HP:0100626)3.09230380
33Pancreatic cysts (HP:0001737)3.06516175
34Cerebellar dysplasia (HP:0007033)2.96546145
35Resting tremor (HP:0002322)2.94890407
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84590180
37Bronchiectasis (HP:0002110)2.83577704
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.81429789
39Chromsome breakage (HP:0040012)2.80600469
40True hermaphroditism (HP:0010459)2.77364077
41Breast hypoplasia (HP:0003187)2.77276349
42Optic neuritis (HP:0100653)2.75854378
43Retrobulbar optic neuritis (HP:0100654)2.75854378
44Abnormality of the nasal mucosa (HP:0000433)2.74541765
45Premature ovarian failure (HP:0008209)2.74384926
46Absent thumb (HP:0009777)2.72821714
47Occipital encephalocele (HP:0002085)2.69334629
48Abnormal sex determination (HP:0012244)2.68883419
49Sex reversal (HP:0012245)2.68883419
50Pancreatic fibrosis (HP:0100732)2.64541121
51Anterior segment dysgenesis (HP:0007700)2.64347584
52Stomatitis (HP:0010280)2.62307758
53Upper motor neuron abnormality (HP:0002127)2.58823108
54Progressive inability to walk (HP:0002505)2.58600227
55Congenital stationary night blindness (HP:0007642)2.57768323
56Absent radius (HP:0003974)2.56598622
57Urinary urgency (HP:0000012)2.53785136
58Missing ribs (HP:0000921)2.53152738
59Reduced antithrombin III activity (HP:0001976)2.52812761
60Retinal atrophy (HP:0001105)2.51113609
61Abnormal rod and cone electroretinograms (HP:0008323)2.50024127
62Absent speech (HP:0001344)2.48879834
63Protruding tongue (HP:0010808)2.47922798
64Abnormal biliary tract physiology (HP:0012439)2.46562992
65Bile duct proliferation (HP:0001408)2.46562992
66Aplasia/hypoplasia of the humerus (HP:0006507)2.45295000
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.45152052
68Medulloblastoma (HP:0002885)2.44929243
69Abnormality of the ileum (HP:0001549)2.44876290
70Meckel diverticulum (HP:0002245)2.44118782
71Congenital sensorineural hearing impairment (HP:0008527)2.43221037
72Short humerus (HP:0005792)2.42263221
73Gonadal dysgenesis (HP:0000133)2.41550638
74Aplasia involving forearm bones (HP:0009822)2.41384662
75Absent forearm bone (HP:0003953)2.41384662
76Abnormality of the preputium (HP:0100587)2.41184480
77Bronchitis (HP:0012387)2.40273391
78Abnormality of the astrocytes (HP:0100707)2.39886418
79Astrocytoma (HP:0009592)2.39886418
80Ventricular fibrillation (HP:0001663)2.39103313
81Abnormality of chromosome stability (HP:0003220)2.38069106
82Hypoplasia of the capital femoral epiphysis (HP:0003090)2.37247701
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.37078201
84Abnormality of the labia minora (HP:0012880)2.33665776
85Abnormality of macular pigmentation (HP:0008002)2.32354071
86Birth length less than 3rd percentile (HP:0003561)2.31987811
87Facial cleft (HP:0002006)2.30353448
88Fibular hypoplasia (HP:0003038)2.28700733
89Attenuation of retinal blood vessels (HP:0007843)2.28098979
90Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27824925
91Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27824925
92Abnormality of abdominal situs (HP:0011620)2.23920558
93Abdominal situs inversus (HP:0003363)2.23920558
94Abnormality of the columella (HP:0009929)2.22166578
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20978787
96Abnormal protein N-linked glycosylation (HP:0012347)2.20978787
97Abnormal protein glycosylation (HP:0012346)2.20978787
98Abnormal glycosylation (HP:0012345)2.20978787
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20552076
100Ectopic kidney (HP:0000086)2.20348944
101Cystic liver disease (HP:0006706)2.19826700
102Rhabdomyosarcoma (HP:0002859)2.19771772
103Fair hair (HP:0002286)2.18958698
104Abnormality of the renal medulla (HP:0100957)2.18479504
105Polydipsia (HP:0001959)2.17946746
106Abnormal drinking behavior (HP:0030082)2.17946746
107Heterotopia (HP:0002282)2.16588560
108Keratoconjunctivitis (HP:0001096)2.15547259
109Carpal bone hypoplasia (HP:0001498)2.14869749
110Anencephaly (HP:0002323)2.14665707
111Short ribs (HP:0000773)2.13596569
112Postural instability (HP:0002172)2.13518900
113Sloping forehead (HP:0000340)2.13457785
114Hypoplasia of the radius (HP:0002984)2.11465399
115Photophobia (HP:0000613)2.10116851
116Abnormality of lateral ventricle (HP:0030047)2.08687104
117Secondary amenorrhea (HP:0000869)2.08257371
118Orchitis (HP:0100796)2.07490799
119Decreased central vision (HP:0007663)2.07482901
120Neoplasm of the oral cavity (HP:0100649)2.06567002
121Tubular atrophy (HP:0000092)2.04357881
122Duodenal stenosis (HP:0100867)2.03376062
123Small intestinal stenosis (HP:0012848)2.03376062
124Sensory axonal neuropathy (HP:0003390)2.01977995
125Neoplasm of striated muscle (HP:0009728)2.01613068
126Patellar aplasia (HP:0006443)1.99729039
127Glioma (HP:0009733)1.99407064
128Tongue fasciculations (HP:0001308)1.99287250
129Hypothermia (HP:0002045)1.98938964
130Squamous cell carcinoma (HP:0002860)1.98445026
131Cerebral hypomyelination (HP:0006808)1.98191124
132Personality changes (HP:0000751)1.95946280
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.94510515
134Agnosia (HP:0010524)1.93502451
135Keratoconjunctivitis sicca (HP:0001097)1.93282604
136Medial flaring of the eyebrow (HP:0010747)1.92081301
137Colon cancer (HP:0003003)1.91825795
138Duplicated collecting system (HP:0000081)1.90956479
139Prominent nose (HP:0000448)1.90374573
140Median cleft lip (HP:0000161)1.89576773
141Widely spaced teeth (HP:0000687)1.88812925
142Gaze-evoked nystagmus (HP:0000640)1.87801353
143Polyneuropathy (HP:0001271)1.87490662
144Abnormality of the renal cortex (HP:0011035)1.86083312
145Febrile seizures (HP:0002373)1.85982715
146Facial hemangioma (HP:0000329)1.85803396
147Parakeratosis (HP:0001036)1.84738568
148Atonic seizures (HP:0010819)1.84690174
149Ketosis (HP:0001946)1.84673952
150Spinal muscular atrophy (HP:0007269)1.84121411
151Recurrent otitis media (HP:0000403)1.83664994
152Unsteady gait (HP:0002317)1.83301790
153Abnormality of the fovea (HP:0000493)1.82547893
154Oligodactyly (hands) (HP:0001180)1.82456941
155Aplasia/Hypoplasia of the patella (HP:0006498)1.81951401
156Tubulointerstitial abnormality (HP:0001969)1.81520970
157Hand muscle atrophy (HP:0009130)1.81151514
158Capillary hemangiomas (HP:0005306)1.79304832
159Intellectual disability, progressive (HP:0006887)1.79274348
160Muscle fibrillation (HP:0010546)1.78512352
161Polyuria (HP:0000103)1.77108932
162Mutism (HP:0002300)1.75764954
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75311142
164Absent epiphyses (HP:0010577)1.75311142
165Abnormality of the carotid arteries (HP:0005344)1.74656697
166Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73976307
167Oral leukoplakia (HP:0002745)1.73905492
168Metaphyseal cupping (HP:0003021)1.73506109
169Myositis (HP:0100614)1.73384875
170Optic nerve hypoplasia (HP:0000609)1.72824115
171Nephroblastoma (Wilms tumor) (HP:0002667)1.72242866
172Abolished electroretinogram (ERG) (HP:0000550)1.71965256
173Basal cell carcinoma (HP:0002671)1.68810040
174Rib fusion (HP:0000902)1.68017754
175Tubulointerstitial nephritis (HP:0001970)1.67280669
176Short thumb (HP:0009778)1.67141117
177Abnormality of midbrain morphology (HP:0002418)1.66977940
178Molar tooth sign on MRI (HP:0002419)1.66977940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.46194289
2PDK46.46194289
3MARK34.20064164
4PDK24.19879154
5FRK3.69091417
6ICK3.45739026
7CDC73.34835233
8ZAK3.20727533
9NEK23.14377531
10CDK123.05321153
11BUB12.97399961
12WEE12.88806161
13TTK2.68253362
14TESK12.64053994
15PRKD32.52495151
16PNCK2.28498191
17ADRBK22.16808445
18INSRR2.10736525
19EPHA21.98331268
20MAP2K71.70233634
21GRK71.67997609
22MAP4K21.67317909
23PLK11.66917030
24RPS6KA51.59682187
25CSNK1G31.56771568
26ATR1.56534205
27MYLK1.50995344
28CSNK1G11.50246026
29TRIM281.50175420
30CDK71.46364511
31CHEK21.45743717
32CSNK1A1L1.45520027
33TYRO31.43316315
34BMPR1B1.38306338
35CSNK1G21.38093071
36OXSR11.32869295
37DYRK31.29204546
38CHEK11.28724330
39VRK11.26911272
40TXK1.26354635
41ACVR1B1.26193386
42MAP3K41.23838908
43FGR1.18616626
44PKN11.17474303
45PLK41.17316030
46PASK1.14506826
47STK31.10757485
48MAP3K51.09714486
49EIF2AK31.07768005
50NUAK11.07365501
51GRK11.07175282
52BRD41.03970543
53STK38L1.03505635
54NEK11.03352736
55MAPK131.02911189
56PTK2B1.02115958
57CDK41.01803717
58MAP2K61.01432981
59TSSK60.99130783
60RPS6KB20.97564835
61ARAF0.93464109
62MAPK150.92589049
63ATM0.92125598
64TESK20.91962829
65AKT30.91910045
66AURKA0.91837918
67MTOR0.90270142
68CDK30.89089243
69AURKB0.88469961
70PRKCQ0.88382509
71EEF2K0.87520207
72STK380.85359127
73EIF2AK10.83717297
74FGFR20.82568278
75DYRK1B0.79228872
76IKBKB0.78194562
77MAP3K60.77106713
78CDK20.77057628
79PAK40.75490830
80IKBKE0.74299781
81IRAK20.74100384
82SRPK10.73604569
83TIE10.72024893
84MUSK0.71248666
85MOS0.70596514
86MAP3K80.68879838
87BCR0.68305549
88MAPKAPK30.67471981
89WNK40.65300849
90PAK10.64496156
91TGFBR10.63845810
92PINK10.63259661
93LATS20.61029916
94EGFR0.60618350
95BRSK20.60593392
96GRK50.57745982
97CCNB10.57167935
98CDK10.56509045
99STK100.56467916
100PLK30.56308581
101PIM10.54280194
102IRAK10.53679018
103BRAF0.53678603
104CAMK10.52686813
105STK160.51295198
106CAMK1G0.50964517
107CLK10.50728795
108MAP3K100.47859993
109CSNK2A20.47377969
110CSNK1E0.45873036
111TNIK0.45388775
112STK390.45000057
113MET0.44711831
114BRSK10.42568229
115SGK2230.42266460
116SGK4940.42266460
117CDK50.42193645
118MAP3K130.41359055
119LATS10.41010926
120PRKCE0.39594420
121IRAK30.39256105
122CSNK2A10.38869470
123ALK0.37790036
124PRKG20.37731518
125ADRBK10.37267169
126CDK140.37196466
127TAOK10.36800838
128MST1R0.36361945
129CDK60.36302263
130CSNK1A10.36289186
131PLK20.36183711
132STK40.35842306
133BMX0.35018464
134PRKDC0.34512486
135PRKG10.34446539
136PRKCI0.33692061
137FER0.33680122
138TBK10.32787275
139DDR20.32277700
140WNK10.31692573
141CDK190.31476444
142CSNK1D0.31271613
143WNK30.31267679
144MELK0.31139477
145CDK90.29624170
146GSK3B0.28827271
147DAPK20.28142707
148TLK10.28083593
149EPHA30.28011444
150NTRK20.27121601
151PAK20.26735409
152RPS6KA10.26500361
153CAMKK20.26210586
154OBSCN0.23795230
155PIM20.23656281
156MAP2K20.23538121
157DAPK10.23302355
158TNK20.22949761
159MAPK140.22397864
160PDK10.21923465
161MAPK10.21690680
162PRKAA10.21332116
163RPS6KB10.20826844
164DYRK20.19260367
165MKNK20.19028306
166MAPK100.17131101
167MAP3K90.16860390
168SCYL20.14518472
169AKT10.13105704
170RPS6KA40.12625701
171FGFR10.12189503

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051304.52812762
2DNA replication_Homo sapiens_hsa030304.08771547
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98189052
4Mismatch repair_Homo sapiens_hsa034303.91804091
5RNA transport_Homo sapiens_hsa030133.72378420
6Homologous recombination_Homo sapiens_hsa034403.27139857
7Fanconi anemia pathway_Homo sapiens_hsa034603.25297510
8Basal transcription factors_Homo sapiens_hsa030222.94729979
9Base excision repair_Homo sapiens_hsa034102.88513248
10Spliceosome_Homo sapiens_hsa030402.82100560
11Gap junction_Homo sapiens_hsa045402.70068434
12Nucleotide excision repair_Homo sapiens_hsa034202.63161417
13Cell cycle_Homo sapiens_hsa041102.57845585
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.55336329
15Vitamin B6 metabolism_Homo sapiens_hsa007502.53340786
16mRNA surveillance pathway_Homo sapiens_hsa030152.52716184
17Phototransduction_Homo sapiens_hsa047442.50718488
18RNA polymerase_Homo sapiens_hsa030202.46391979
19Proteasome_Homo sapiens_hsa030502.36272925
20Olfactory transduction_Homo sapiens_hsa047402.30008272
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19809238
22Butanoate metabolism_Homo sapiens_hsa006502.06895303
23Oocyte meiosis_Homo sapiens_hsa041141.95417902
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94339024
25Nitrogen metabolism_Homo sapiens_hsa009101.91309578
26Pyrimidine metabolism_Homo sapiens_hsa002401.88032497
27RNA degradation_Homo sapiens_hsa030181.80390558
28Selenocompound metabolism_Homo sapiens_hsa004501.79818326
29Phagosome_Homo sapiens_hsa041451.78496065
30One carbon pool by folate_Homo sapiens_hsa006701.71575945
31Dorso-ventral axis formation_Homo sapiens_hsa043201.70300999
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.70150378
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66870038
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63571798
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.57071826
36Pyruvate metabolism_Homo sapiens_hsa006201.54087584
37Non-homologous end-joining_Homo sapiens_hsa034501.53386512
38Fatty acid biosynthesis_Homo sapiens_hsa000611.51211465
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50700699
40p53 signaling pathway_Homo sapiens_hsa041151.49546891
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49397378
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48683441
43Nicotine addiction_Homo sapiens_hsa050331.47189037
44Apoptosis_Homo sapiens_hsa042101.46371393
45Tryptophan metabolism_Homo sapiens_hsa003801.46173108
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45805909
47Collecting duct acid secretion_Homo sapiens_hsa049661.44359598
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44161747
49Ovarian steroidogenesis_Homo sapiens_hsa049131.34875758
50Circadian rhythm_Homo sapiens_hsa047101.33307241
51Taste transduction_Homo sapiens_hsa047421.30702639
52Biosynthesis of amino acids_Homo sapiens_hsa012301.29620623
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.28387815
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24844234
55Linoleic acid metabolism_Homo sapiens_hsa005911.22401168
56Purine metabolism_Homo sapiens_hsa002301.19200690
57Rheumatoid arthritis_Homo sapiens_hsa053231.18350208
58Pentose phosphate pathway_Homo sapiens_hsa000301.16956053
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15507533
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15159225
61NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08930525
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06674640
63Chemical carcinogenesis_Homo sapiens_hsa052041.06272688
64Ribosome_Homo sapiens_hsa030101.05383513
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02761150
66Fructose and mannose metabolism_Homo sapiens_hsa000511.02186097
67Epstein-Barr virus infection_Homo sapiens_hsa051690.95045759
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91715460
69Antigen processing and presentation_Homo sapiens_hsa046120.90859642
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.88057877
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87671365
72Glucagon signaling pathway_Homo sapiens_hsa049220.86325825
73Hedgehog signaling pathway_Homo sapiens_hsa043400.85815270
74Carbon metabolism_Homo sapiens_hsa012000.83417182
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.83303947
76African trypanosomiasis_Homo sapiens_hsa051430.83157084
77beta-Alanine metabolism_Homo sapiens_hsa004100.81442692
78Sphingolipid metabolism_Homo sapiens_hsa006000.80548257
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80004039
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77873398
81Huntingtons disease_Homo sapiens_hsa050160.77764160
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76127412
83Glycerolipid metabolism_Homo sapiens_hsa005610.74967128
84Viral carcinogenesis_Homo sapiens_hsa052030.73594166
85Basal cell carcinoma_Homo sapiens_hsa052170.73152289
86Hippo signaling pathway_Homo sapiens_hsa043900.72508904
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71353420
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.70173387
89Systemic lupus erythematosus_Homo sapiens_hsa053220.68143724
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67523449
91GABAergic synapse_Homo sapiens_hsa047270.67275661
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65187769
93Glutathione metabolism_Homo sapiens_hsa004800.65168049
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64641419
95TNF signaling pathway_Homo sapiens_hsa046680.64455012
96ABC transporters_Homo sapiens_hsa020100.61299039
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.61034976
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60876118
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.59974911
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59915984
101Calcium signaling pathway_Homo sapiens_hsa040200.59570064
102Caffeine metabolism_Homo sapiens_hsa002320.58448297
103Peroxisome_Homo sapiens_hsa041460.57768997
104Synaptic vesicle cycle_Homo sapiens_hsa047210.56724434
105mTOR signaling pathway_Homo sapiens_hsa041500.55849895
106TGF-beta signaling pathway_Homo sapiens_hsa043500.55786061
107Notch signaling pathway_Homo sapiens_hsa043300.54674062
108HTLV-I infection_Homo sapiens_hsa051660.53712328
109Fatty acid degradation_Homo sapiens_hsa000710.53234639
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52337489
111Propanoate metabolism_Homo sapiens_hsa006400.52327234
112Fatty acid metabolism_Homo sapiens_hsa012120.51933187
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.51440318
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.50797659
115Morphine addiction_Homo sapiens_hsa050320.50608316
116Malaria_Homo sapiens_hsa051440.49984512
117Folate biosynthesis_Homo sapiens_hsa007900.49027154
118Protein export_Homo sapiens_hsa030600.47903936
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47068237
120Pertussis_Homo sapiens_hsa051330.46203265
121Tight junction_Homo sapiens_hsa045300.46183260
122Herpes simplex infection_Homo sapiens_hsa051680.45729857
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45241523
124Fat digestion and absorption_Homo sapiens_hsa049750.45036070
125Salivary secretion_Homo sapiens_hsa049700.44896146
126Lysine degradation_Homo sapiens_hsa003100.44789626
127Parkinsons disease_Homo sapiens_hsa050120.44439457
128Legionellosis_Homo sapiens_hsa051340.43773184
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43737101
130Asthma_Homo sapiens_hsa053100.43258640
131Lysosome_Homo sapiens_hsa041420.43224165
132Renin secretion_Homo sapiens_hsa049240.42549566
133Retinol metabolism_Homo sapiens_hsa008300.40291699
134Allograft rejection_Homo sapiens_hsa053300.39281907
135Influenza A_Homo sapiens_hsa051640.37168231
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35900633
137Wnt signaling pathway_Homo sapiens_hsa043100.35337396
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34816017
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34379907
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30465234
141Sulfur relay system_Homo sapiens_hsa041220.30270527
142MicroRNAs in cancer_Homo sapiens_hsa052060.29810768
143Adherens junction_Homo sapiens_hsa045200.29700084
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.29374419
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26759140
146HIF-1 signaling pathway_Homo sapiens_hsa040660.26229873
147Ether lipid metabolism_Homo sapiens_hsa005650.25752539
148AMPK signaling pathway_Homo sapiens_hsa041520.24665946
149Arachidonic acid metabolism_Homo sapiens_hsa005900.22309080
150Metabolic pathways_Homo sapiens_hsa011000.21319865
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20360604
152Small cell lung cancer_Homo sapiens_hsa052220.19278233
153Alcoholism_Homo sapiens_hsa050340.17630935
154Mineral absorption_Homo sapiens_hsa049780.17437023
155Arginine and proline metabolism_Homo sapiens_hsa003300.16608214
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16066868
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.15597760
158Vitamin digestion and absorption_Homo sapiens_hsa049770.15495465
159VEGF signaling pathway_Homo sapiens_hsa043700.15224763
160Thyroid cancer_Homo sapiens_hsa052160.13411173
161Renin-angiotensin system_Homo sapiens_hsa046140.10466601
162Estrogen signaling pathway_Homo sapiens_hsa049150.08796600
163Inositol phosphate metabolism_Homo sapiens_hsa005620.08533326
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07243954
165Bladder cancer_Homo sapiens_hsa052190.05403859
166Regulation of autophagy_Homo sapiens_hsa041400.04961332

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