ADAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)5.03088690
2regulation of rhodopsin mediated signaling pathway (GO:0022400)4.90081896
3rhodopsin mediated signaling pathway (GO:0016056)4.79240042
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.35503895
5detection of light stimulus involved in visual perception (GO:0050908)4.31301405
6detection of light stimulus involved in sensory perception (GO:0050962)4.31301405
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.30740730
8photoreceptor cell development (GO:0042461)4.07011778
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02933390
10eye photoreceptor cell development (GO:0042462)4.01288450
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88308652
12ATP synthesis coupled proton transport (GO:0015986)3.88308652
13retinal rod cell development (GO:0046548)3.80043072
14GMP metabolic process (GO:0046037)3.60237245
15L-phenylalanine catabolic process (GO:0006559)3.56177226
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.56177226
17respiratory electron transport chain (GO:0022904)3.55057371
18mitochondrial respiratory chain complex assembly (GO:0033108)3.52956042
19electron transport chain (GO:0022900)3.51503570
20chromatin remodeling at centromere (GO:0031055)3.49526698
21lysine metabolic process (GO:0006553)3.48232547
22lysine catabolic process (GO:0006554)3.48232547
23protein-cofactor linkage (GO:0018065)3.42276554
24CENP-A containing nucleosome assembly (GO:0034080)3.39434850
25regulation of meiosis I (GO:0060631)3.39005532
26photoreceptor cell maintenance (GO:0045494)3.33866785
27synapsis (GO:0007129)3.32848348
28centriole replication (GO:0007099)3.32182308
29oxaloacetate metabolic process (GO:0006107)3.29915491
30replication fork processing (GO:0031297)3.29689304
31nonmotile primary cilium assembly (GO:0035058)3.29297652
32behavioral response to nicotine (GO:0035095)3.21930685
33L-phenylalanine metabolic process (GO:0006558)3.20025904
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.20025904
35DNA replication checkpoint (GO:0000076)3.16479613
36piRNA metabolic process (GO:0034587)3.11481066
37succinate metabolic process (GO:0006105)3.10322649
38response to pheromone (GO:0019236)3.09614667
39protein neddylation (GO:0045116)3.06016416
40respiratory chain complex IV assembly (GO:0008535)3.05214804
41meiotic chromosome segregation (GO:0045132)3.01502725
42histone exchange (GO:0043486)3.00579790
43water-soluble vitamin biosynthetic process (GO:0042364)3.00197143
44aspartate family amino acid catabolic process (GO:0009068)2.99418211
45proteasome assembly (GO:0043248)2.98907731
46protein K6-linked ubiquitination (GO:0085020)2.98236194
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97240561
48negative regulation of DNA-dependent DNA replication (GO:2000104)2.93220528
49kinetochore organization (GO:0051383)2.92758320
50fat-soluble vitamin biosynthetic process (GO:0042362)2.89892017
51recombinational repair (GO:0000725)2.89474208
52resolution of meiotic recombination intermediates (GO:0000712)2.88079852
53double-strand break repair via homologous recombination (GO:0000724)2.87919770
54positive regulation of mitochondrial fission (GO:0090141)2.87891529
55cytochrome complex assembly (GO:0017004)2.86787547
56cellular ketone body metabolic process (GO:0046950)2.85537826
572-oxoglutarate metabolic process (GO:0006103)2.84983951
58aromatic amino acid family catabolic process (GO:0009074)2.84855080
59prenylation (GO:0097354)2.84100912
60protein prenylation (GO:0018342)2.84100912
61bile acid biosynthetic process (GO:0006699)2.83520073
62reciprocal meiotic recombination (GO:0007131)2.81233455
63reciprocal DNA recombination (GO:0035825)2.81233455
64protein import into peroxisome matrix (GO:0016558)2.76990120
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76412791
66kinetochore assembly (GO:0051382)2.75112589
67regulation of bile acid biosynthetic process (GO:0070857)2.74724842
68male meiosis I (GO:0007141)2.73453786
69platelet dense granule organization (GO:0060155)2.73190385
70intraciliary transport (GO:0042073)2.73118676
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71714338
72epithelial cilium movement (GO:0003351)2.71215975
73termination of RNA polymerase III transcription (GO:0006386)2.70814359
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.70814359
75organelle disassembly (GO:1903008)2.70394452
76pyrimidine nucleobase catabolic process (GO:0006208)2.69082157
77regulation of DNA endoreduplication (GO:0032875)2.68838759
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68244844
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66816739
80cysteine metabolic process (GO:0006534)2.65962666
81chaperone-mediated protein transport (GO:0072321)2.65835966
82glyoxylate metabolic process (GO:0046487)2.64388098
83ketone body metabolic process (GO:1902224)2.63869453
84oxidative phosphorylation (GO:0006119)2.60838188
85synaptic vesicle docking involved in exocytosis (GO:0016081)2.60604058
86quinone biosynthetic process (GO:1901663)2.60399503
87ubiquinone biosynthetic process (GO:0006744)2.60399503
88DNA double-strand break processing (GO:0000729)2.58537927
89peptidyl-histidine modification (GO:0018202)2.55957356
90mannosylation (GO:0097502)2.55920225
91somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55429634
92somatic hypermutation of immunoglobulin genes (GO:0016446)2.55429634
93lactate metabolic process (GO:0006089)2.54416732
94postreplication repair (GO:0006301)2.54391873
95glycine metabolic process (GO:0006544)2.54217753
96detection of light stimulus (GO:0009583)2.53285343
97base-excision repair, AP site formation (GO:0006285)2.52910387
98cullin deneddylation (GO:0010388)2.52233546
99striatum development (GO:0021756)2.52072150
100folic acid metabolic process (GO:0046655)2.51951936
101detection of visible light (GO:0009584)2.51664834
102visual perception (GO:0007601)2.51605756
103ATP biosynthetic process (GO:0006754)2.50778865
104sensory perception of light stimulus (GO:0050953)2.50051038
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48249788
106DNA methylation involved in gamete generation (GO:0043046)2.47453189
107translesion synthesis (GO:0019985)2.47320861
108fatty acid elongation (GO:0030497)2.46422917
109DNA replication-independent nucleosome assembly (GO:0006336)2.46346663
110DNA replication-independent nucleosome organization (GO:0034724)2.46346663
111hydrogen ion transmembrane transport (GO:1902600)2.46258047
112ubiquinone metabolic process (GO:0006743)2.45674495
113sulfur amino acid biosynthetic process (GO:0000097)2.45527527
114cerebellar Purkinje cell differentiation (GO:0021702)2.45233510
115NADH metabolic process (GO:0006734)2.45071163
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.44917402
117regulation of mitotic spindle checkpoint (GO:1903504)2.44101223
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44101223
119positive regulation of meiosis (GO:0045836)2.43883906
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43522138
121S-adenosylmethionine metabolic process (GO:0046500)2.43132025
122phototransduction (GO:0007602)2.43082727
123tricarboxylic acid cycle (GO:0006099)2.42821333
124coenzyme catabolic process (GO:0009109)2.42780867
125serine family amino acid catabolic process (GO:0009071)2.41966836
126intracellular protein transmembrane import (GO:0044743)2.41728864
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.41376623
128pyrimidine dimer repair (GO:0006290)2.41124694
129inner mitochondrial membrane organization (GO:0007007)2.40339455
130aspartate family amino acid metabolic process (GO:0009066)2.40283432
131homocysteine metabolic process (GO:0050667)2.39482430
132methionine biosynthetic process (GO:0009086)2.39454608
133synaptic vesicle exocytosis (GO:0016079)2.38978466
134phototransduction, visible light (GO:0007603)2.38892397
135pyrimidine nucleotide catabolic process (GO:0006244)2.37011449
136bile acid metabolic process (GO:0008206)2.36464485
137methionine metabolic process (GO:0006555)2.36117176
138alpha-amino acid catabolic process (GO:1901606)2.35949822
139cilium morphogenesis (GO:0060271)2.35781114
140kynurenine metabolic process (GO:0070189)2.35253271
141regulation of hexokinase activity (GO:1903299)2.34799216
142regulation of glucokinase activity (GO:0033131)2.34799216
143protein-chromophore linkage (GO:0018298)2.34574053
144cilium organization (GO:0044782)2.34539044
145serine family amino acid metabolic process (GO:0009069)2.34458341
146regulation of short-term neuronal synaptic plasticity (GO:0048172)2.34218336
147purine nucleoside triphosphate biosynthetic process (GO:0009145)2.34090857
148protein complex biogenesis (GO:0070271)2.34087436
149deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.33977367
150single strand break repair (GO:0000012)2.33859000
151amino acid salvage (GO:0043102)2.33522032
152L-methionine salvage (GO:0071267)2.33522032
153L-methionine biosynthetic process (GO:0071265)2.33522032
154mitochondrial respiratory chain complex I assembly (GO:0032981)2.33382129
155NADH dehydrogenase complex assembly (GO:0010257)2.33382129
156mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.33382129
157branched-chain amino acid catabolic process (GO:0009083)2.33278890
158cellular response to light stimulus (GO:0071482)2.32333910
159otic vesicle formation (GO:0030916)2.32087395
160meiosis I (GO:0007127)2.31696046
161negative regulation of DNA recombination (GO:0045910)2.31468726
162tyrosine metabolic process (GO:0006570)2.31431283
163L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.31137220
164DNA replication-dependent nucleosome organization (GO:0034723)2.31000822
165DNA replication-dependent nucleosome assembly (GO:0006335)2.31000822
166purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.30959388
167tryptophan metabolic process (GO:0006568)2.30918303
168dicarboxylic acid catabolic process (GO:0043649)2.30573909
169aspartate family amino acid biosynthetic process (GO:0009067)2.30021294
170cilium assembly (GO:0042384)2.29883858
171proton transport (GO:0015992)2.29744290
172* purine nucleobase biosynthetic process (GO:0009113)2.28515516
173regulation of mitochondrial translation (GO:0070129)2.28329787
174indole-containing compound catabolic process (GO:0042436)2.27991125
175indolalkylamine catabolic process (GO:0046218)2.27991125
176tryptophan catabolic process (GO:0006569)2.27991125
177male meiosis (GO:0007140)2.27893666
178RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.27639831
179tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.27639831
180G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26370713
181centrosome organization (GO:0051297)2.24835039
182hydrogen transport (GO:0006818)2.24692665
183telomere maintenance via semi-conservative replication (GO:0032201)2.23931585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.79594781
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.44533999
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04757666
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02027325
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71067477
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59286792
7THAP11_20581084_ChIP-Seq_MESCs_Mouse2.55962417
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46727778
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.44863385
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.44824676
11TAF15_26573619_Chip-Seq_HEK293_Human2.38036518
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34491837
13YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33348387
14GBX2_23144817_ChIP-Seq_PC3_Human2.27966932
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25586948
16FUS_26573619_Chip-Seq_HEK293_Human2.15517578
17* ELK1_19687146_ChIP-ChIP_HELA_Human2.13062773
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08825672
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.02558570
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00764071
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00628724
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.99683038
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.95908014
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93057165
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82658628
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82057228
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81300962
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.76321631
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75700478
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73532238
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.73116717
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71435205
33MYC_18940864_ChIP-ChIP_HL60_Human1.71264235
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.64232554
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63963813
36* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60304454
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59494760
38HTT_18923047_ChIP-ChIP_STHdh_Human1.58304208
39REST_21632747_ChIP-Seq_MESCs_Mouse1.56260364
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55560260
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54864698
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53775563
43IGF1R_20145208_ChIP-Seq_DFB_Human1.53652398
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.52981917
45* GABP_17652178_ChIP-ChIP_JURKAT_Human1.52366610
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52069900
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50585507
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49402273
49EWS_26573619_Chip-Seq_HEK293_Human1.49004277
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47186484
51ZNF274_21170338_ChIP-Seq_K562_Hela1.46337577
52ER_23166858_ChIP-Seq_MCF-7_Human1.45958175
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43649558
54CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.41979855
55IRF1_19129219_ChIP-ChIP_H3396_Human1.41788032
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41189554
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40983336
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38326456
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36583792
60TP53_22573176_ChIP-Seq_HFKS_Human1.36329678
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36174134
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34340422
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.34197931
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33459103
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33261573
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32804297
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32739131
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32436033
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31913736
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31032852
71DCP1A_22483619_ChIP-Seq_HELA_Human1.30744152
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30574990
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28749571
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28608280
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27788389
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.26762804
77FOXP3_21729870_ChIP-Seq_TREG_Human1.26655699
78GABP_19822575_ChIP-Seq_HepG2_Human1.26314821
79* VDR_23849224_ChIP-Seq_CD4+_Human1.26005972
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23353304
81SOX9_26525672_Chip-Seq_HEART_Mouse1.22567697
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21585639
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21338476
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21074065
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20947146
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19865339
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18960600
88CBP_20019798_ChIP-Seq_JUKART_Human1.18960600
89SMAD4_21799915_ChIP-Seq_A2780_Human1.18434923
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18133215
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.17453938
92XRN2_22483619_ChIP-Seq_HELA_Human1.15973332
93BCAT_22108803_ChIP-Seq_LS180_Human1.15710982
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15405033
95STAT3_23295773_ChIP-Seq_U87_Human1.14923740
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13104759
97CIITA_25753668_ChIP-Seq_RAJI_Human1.11729286
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11566825
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.10669452
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10476846
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.10144633
102NANOG_19829295_ChIP-Seq_ESCs_Human1.09153007
103SOX2_19829295_ChIP-Seq_ESCs_Human1.09153007
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08899016
105TTF2_22483619_ChIP-Seq_HELA_Human1.08440938
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07889263
107TCF4_23295773_ChIP-Seq_U87_Human1.07360034
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07231583
109RNF2_27304074_Chip-Seq_NSC_Mouse1.06699545
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06522038
111AR_21909140_ChIP-Seq_LNCAP_Human1.06344187
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05621310
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.05178798
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04916308
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04876002
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04048340
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.03012447
118* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02888736
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02853405
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.02853405
121EZH2_22144423_ChIP-Seq_EOC_Human1.02731319
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01768722
123TCF4_22108803_ChIP-Seq_LS180_Human1.00179077
124TP63_19390658_ChIP-ChIP_HaCaT_Human0.99916261
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98267712
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.97999921
127AR_25329375_ChIP-Seq_VCAP_Human0.97981288
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97817526
129E2F1_21310950_ChIP-Seq_MCF-7_Human0.97500093
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.97310657
131SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96420921
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96152776
133POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94746190
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.93560417
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93490888
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93291305
137PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92800622
138REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92319898
139P300_19829295_ChIP-Seq_ESCs_Human0.92271752
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91506599
141KDM5A_27292631_Chip-Seq_BREAST_Human0.90738493
142FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89509052
143CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87377034
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87127145
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87035489
146VDR_22108803_ChIP-Seq_LS180_Human0.84132933
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84061333
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83303918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.41235004
2MP0002139_abnormal_hepatobiliary_system2.96633912
3MP0005360_urolithiasis2.75541395
4MP0001984_abnormal_olfaction2.73275260
5MP0005365_abnormal_bile_salt2.73101633
6MP0005253_abnormal_eye_physiology2.71811890
7MP0006072_abnormal_retinal_apoptosis2.56075602
8MP0003136_yellow_coat_color2.47755700
9MP0000372_irregular_coat_pigmentation2.43956489
10MP0005085_abnormal_gallbladder_physiolo2.39208413
11MP0003646_muscle_fatigue2.17967046
12MP0001764_abnormal_homeostasis2.14950090
13MP0002090_abnormal_vision2.13318104
14MP0003806_abnormal_nucleotide_metabolis2.13248581
15MP0004233_abnormal_muscle_weight1.99983612
16MP0002638_abnormal_pupillary_reflex1.96778196
17MP0008058_abnormal_DNA_repair1.93398846
18MP0002102_abnormal_ear_morphology1.92624200
19MP0002653_abnormal_ependyma_morphology1.91346483
20MP0003011_delayed_dark_adaptation1.89754681
21MP0001529_abnormal_vocalization1.89659581
22MP0008875_abnormal_xenobiotic_pharmacok1.87555271
23MP0004147_increased_porphyrin_level1.85496630
24MP0003718_maternal_effect1.76695573
25MP0005195_abnormal_posterior_eye1.70493314
26MP0009046_muscle_twitch1.65462449
27MP0005171_absent_coat_pigmentation1.60740307
28MP0002064_seizures1.55430319
29MP0004859_abnormal_synaptic_plasticity1.54555763
30MP0002160_abnormal_reproductive_system1.52945033
31MP0010094_abnormal_chromosome_stability1.49754332
32MP0003195_calcinosis1.48119004
33MP0003635_abnormal_synaptic_transmissio1.47702724
34MP0003880_abnormal_central_pattern1.47580831
35MP0002272_abnormal_nervous_system1.46626294
36MP0004043_abnormal_pH_regulation1.45557506
37MP0001293_anophthalmia1.44642626
38MP0006292_abnormal_olfactory_placode1.40710454
39MP0006035_abnormal_mitochondrial_morpho1.40258083
40MP0003693_abnormal_embryo_hatching1.40223819
41MP0005391_vision/eye_phenotype1.39536928
42MP0008877_abnormal_DNA_methylation1.38986936
43MP0001486_abnormal_startle_reflex1.37595142
44MP0002229_neurodegeneration1.37117448
45MP0003787_abnormal_imprinting1.33634123
46MP0001968_abnormal_touch/_nociception1.33521165
47MP0002063_abnormal_learning/memory/cond1.33416109
48MP0003121_genomic_imprinting1.33215856
49MP0006036_abnormal_mitochondrial_physio1.32231676
50MP0009745_abnormal_behavioral_response1.31378966
51MP0001485_abnormal_pinna_reflex1.31132563
52MP0005248_abnormal_Harderian_gland1.30471954
53MP0001324_abnormal_eye_pigmentation1.29515217
54MP0003111_abnormal_nucleus_morphology1.28494879
55MP0005332_abnormal_amino_acid1.27778797
56MP0000749_muscle_degeneration1.27111711
57MP0005174_abnormal_tail_pigmentation1.25049371
58MP0004142_abnormal_muscle_tone1.24934030
59MP0005220_abnormal_exocrine_pancreas1.24869632
60MP0004084_abnormal_cardiac_muscle1.24318660
61MP0002067_abnormal_sensory_capabilities1.24247730
62MP0002210_abnormal_sex_determination1.23755438
63MP0003937_abnormal_limbs/digits/tail_de1.21935705
64MP0002095_abnormal_skin_pigmentation1.21858279
65MP0009697_abnormal_copulation1.21420026
66MP0005645_abnormal_hypothalamus_physiol1.20932052
67MP0004885_abnormal_endolymph1.20621272
68MP0003656_abnormal_erythrocyte_physiolo1.20377437
69MP0002752_abnormal_somatic_nervous1.20307177
70MP0004036_abnormal_muscle_relaxation1.18618716
71MP0002736_abnormal_nociception_after1.17295811
72MP0002572_abnormal_emotion/affect_behav1.17292433
73MP0005423_abnormal_somatic_nervous1.16484372
74MP0001929_abnormal_gametogenesis1.15578054
75MP0005084_abnormal_gallbladder_morpholo1.15312595
76MP0002184_abnormal_innervation1.14431370
77MP0001986_abnormal_taste_sensitivity1.13894105
78MP0005394_taste/olfaction_phenotype1.13412078
79MP0005499_abnormal_olfactory_system1.13412078
80MP0003122_maternal_imprinting1.13099995
81MP0008057_abnormal_DNA_replication1.11499295
82MP0008995_early_reproductive_senescence1.10393724
83MP0002822_catalepsy1.09142669
84MP0003186_abnormal_redox_activity1.08640659
85MP0008789_abnormal_olfactory_epithelium1.08283803
86MP0003890_abnormal_embryonic-extraembry1.05938037
87MP0004270_analgesia1.05197141
88MP0002882_abnormal_neuron_morphology1.04446143
89MP0008775_abnormal_heart_ventricle1.03968440
90MP0002938_white_spotting1.03549868
91MP0003698_abnormal_male_reproductive1.02221163
92MP0001905_abnormal_dopamine_level1.01544860
93MP0000653_abnormal_sex_gland1.01108585
94MP0006276_abnormal_autonomic_nervous1.01082734
95MP0005389_reproductive_system_phenotype1.00656645
96MP0003567_abnormal_fetal_cardiomyocyte1.00425778
97MP0004957_abnormal_blastocyst_morpholog0.99698818
98MP0001502_abnormal_circadian_rhythm0.99615230
99MP0009379_abnormal_foot_pigmentation0.98973154
100MP0002127_abnormal_cardiovascular_syste0.98684686
101MP0005408_hypopigmentation0.98172363
102MP0000778_abnormal_nervous_system0.98079276
103MP0005646_abnormal_pituitary_gland0.97596941
104MP0005386_behavior/neurological_phenoty0.97558274
105MP0004924_abnormal_behavior0.97558274
106MP0000427_abnormal_hair_cycle0.97527435
107MP0004215_abnormal_myocardial_fiber0.97106120
108MP0005075_abnormal_melanosome_morpholog0.96579589
109MP0001145_abnormal_male_reproductive0.95412919
110MP0002734_abnormal_mechanical_nocicepti0.95330050
111MP0000631_abnormal_neuroendocrine_gland0.95302642
112MP0000566_synostosis0.94530373
113MP0002751_abnormal_autonomic_nervous0.93661773
114MP0003137_abnormal_impulse_conducting0.93584311
115MP0002269_muscular_atrophy0.93001690
116MP0000569_abnormal_digit_pigmentation0.92656218
117MP0003252_abnormal_bile_duct0.91054675
118MP0009672_abnormal_birth_weight0.91020512
119MP0000647_abnormal_sebaceous_gland0.87823894
120MP0002234_abnormal_pharynx_morphology0.85480283
121MP0002163_abnormal_gland_morphology0.85241975
122MP0010329_abnormal_lipoprotein_level0.84736613
123MP0003943_abnormal_hepatobiliary_system0.84276928
124MP0002876_abnormal_thyroid_physiology0.84142989
125MP0003786_premature_aging0.83776299
126MP0001666_abnormal_nutrient_absorption0.83677436
127MP0008932_abnormal_embryonic_tissue0.83353989
128MP0003077_abnormal_cell_cycle0.83338557
129MP0004811_abnormal_neuron_physiology0.82955615
130MP0003868_abnormal_feces_composition0.81398215
131MP0004133_heterotaxia0.81232080
132MP0008872_abnormal_physiological_respon0.81019852
133MP0002735_abnormal_chemical_nociception0.79616925
134MP0004145_abnormal_muscle_electrophysio0.79555618
135MP0004742_abnormal_vestibular_system0.79404854
136MP0010030_abnormal_orbit_morphology0.78148679
137MP0005410_abnormal_fertilization0.77315168
138MP0008569_lethality_at_weaning0.76385078
139MP0005187_abnormal_penis_morphology0.76089922
140MP0004085_abnormal_heartbeat0.75455922
141MP0002152_abnormal_brain_morphology0.74688303
142MP0002066_abnormal_motor_capabilities/c0.74161680
143MP0000955_abnormal_spinal_cord0.73844121
144MP0002837_dystrophic_cardiac_calcinosis0.72856907
145MP0002557_abnormal_social/conspecific_i0.72652742

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.43558966
2Central scotoma (HP:0000603)4.57380374
3Bony spicule pigmentary retinopathy (HP:0007737)4.28665612
4Chorioretinal atrophy (HP:0000533)4.06021797
5Abnormal rod and cone electroretinograms (HP:0008323)3.79301094
6Abnormality of macular pigmentation (HP:0008002)3.73745352
7Pancreatic cysts (HP:0001737)3.58876744
8Pendular nystagmus (HP:0012043)3.42291196
9Mitochondrial inheritance (HP:0001427)3.38447886
10Progressive macrocephaly (HP:0004481)3.24732980
11Molar tooth sign on MRI (HP:0002419)3.20692577
12Abnormality of midbrain morphology (HP:0002418)3.20692577
13Decreased central vision (HP:0007663)3.15313755
14Increased CSF lactate (HP:0002490)3.13244729
15Pigmentary retinal degeneration (HP:0001146)3.11297722
16Scotoma (HP:0000575)3.08955802
17Gait imbalance (HP:0002141)3.05670331
18Poor coordination (HP:0002370)3.05506233
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.01137412
20Epileptic encephalopathy (HP:0200134)3.00565341
21Congenital primary aphakia (HP:0007707)2.97951943
22Hyperventilation (HP:0002883)2.94647238
23Increased hepatocellular lipid droplets (HP:0006565)2.91425525
24Hypobetalipoproteinemia (HP:0003563)2.90054001
25Severe visual impairment (HP:0001141)2.88241748
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88194984
27Hepatic necrosis (HP:0002605)2.88087972
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.81195728
29Chromsome breakage (HP:0040012)2.78693839
30Lipid accumulation in hepatocytes (HP:0006561)2.76763605
31Nephronophthisis (HP:0000090)2.76655283
32Nephrogenic diabetes insipidus (HP:0009806)2.71147489
33Focal motor seizures (HP:0011153)2.69999746
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69287311
35Type II diabetes mellitus (HP:0005978)2.62521599
36Chronic hepatic failure (HP:0100626)2.60446145
37Medial flaring of the eyebrow (HP:0010747)2.60019599
38Meckel diverticulum (HP:0002245)2.56738816
39Abnormality of the ileum (HP:0001549)2.56125902
40Abnormality of the lower motor neuron (HP:0002366)2.52373585
41Hyperglycinemia (HP:0002154)2.51119698
42Retinitis pigmentosa (HP:0000510)2.47932542
43Colon cancer (HP:0003003)2.44345136
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.43115415
45Intrahepatic cholestasis (HP:0001406)2.42419312
46Abnormality of glycolysis (HP:0004366)2.41012473
47Increased serum pyruvate (HP:0003542)2.41012473
48True hermaphroditism (HP:0010459)2.40167324
49Abnormality of chromosome stability (HP:0003220)2.39729238
50Abnormality of the renal cortex (HP:0011035)2.38802859
51Vaginal atresia (HP:0000148)2.38175370
52Attenuation of retinal blood vessels (HP:0007843)2.37932733
533-Methylglutaconic aciduria (HP:0003535)2.36302539
54Sclerocornea (HP:0000647)2.33426020
55Keratoconus (HP:0000563)2.31977824
56Increased corneal curvature (HP:0100692)2.31977824
57Protruding tongue (HP:0010808)2.30899874
58Genital tract atresia (HP:0001827)2.30659224
59Renal Fanconi syndrome (HP:0001994)2.30301862
60Febrile seizures (HP:0002373)2.29452260
61Abnormality of the renal medulla (HP:0100957)2.26061481
62Methylmalonic acidemia (HP:0002912)2.22950530
63Hepatoblastoma (HP:0002884)2.21826867
64Absence seizures (HP:0002121)2.17162768
65Abnormal number of erythroid precursors (HP:0012131)2.15973446
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13930377
67Increased serum lactate (HP:0002151)2.13775445
68Photophobia (HP:0000613)2.12554269
69Brushfield spots (HP:0001088)2.10514718
70Lactic acidosis (HP:0003128)2.10291791
71Dyschromatopsia (HP:0007641)2.10206387
72Hyperglycinuria (HP:0003108)2.09145648
73Atonic seizures (HP:0010819)2.08987922
74Abolished electroretinogram (ERG) (HP:0000550)2.07513576
75Abnormal mitochondria in muscle tissue (HP:0008316)2.03863666
76Ependymoma (HP:0002888)2.03292547
77Postaxial foot polydactyly (HP:0001830)2.02685792
78Anencephaly (HP:0002323)2.01640057
79Type II lissencephaly (HP:0007260)2.01399402
80Supernumerary spleens (HP:0009799)2.01256309
81Intestinal atresia (HP:0011100)2.00549061
82Hypothermia (HP:0002045)2.00396444
83Large for gestational age (HP:0001520)2.00260151
84Reticulocytopenia (HP:0001896)2.00220472
85Increased intramyocellular lipid droplets (HP:0012240)1.99895095
86Optic disc pallor (HP:0000543)1.98703688
87Cystic liver disease (HP:0006706)1.98465539
88Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98354162
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98354162
90Abnormality of the preputium (HP:0100587)1.97887837
91Methylmalonic aciduria (HP:0012120)1.97847879
92Abnormality of methionine metabolism (HP:0010901)1.97658739
93Abnormal hair whorl (HP:0010721)1.97243833
94Ketosis (HP:0001946)1.97085382
95Sloping forehead (HP:0000340)1.96432315
96Abnormality of cells of the erythroid lineage (HP:0012130)1.94528561
97Spastic gait (HP:0002064)1.94498749
98Polydipsia (HP:0001959)1.94385071
99Abnormal drinking behavior (HP:0030082)1.94385071
100Generalized aminoaciduria (HP:0002909)1.93252999
101Abnormality of the labia minora (HP:0012880)1.92693413
102Widely patent fontanelles and sutures (HP:0004492)1.91855678
103Rimmed vacuoles (HP:0003805)1.91676469
104Renal cortical cysts (HP:0000803)1.91632669
105Male pseudohermaphroditism (HP:0000037)1.91557993
106Volvulus (HP:0002580)1.89506659
107Bile duct proliferation (HP:0001408)1.89281867
108Abnormal biliary tract physiology (HP:0012439)1.89281867
109Abnormality of sulfur amino acid metabolism (HP:0004339)1.88922195
110Deep venous thrombosis (HP:0002625)1.87965129
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.87876798
112Posterior subcapsular cataract (HP:0007787)1.87192148
113Congenital hepatic fibrosis (HP:0002612)1.86606928
114Triphalangeal thumb (HP:0001199)1.86470940
115Respiratory failure (HP:0002878)1.85771012
116Abnormality of urine glucose concentration (HP:0011016)1.84618561
117Glycosuria (HP:0003076)1.84618561
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84504320
119Abnormality of alanine metabolism (HP:0010916)1.84504320
120Hyperalaninemia (HP:0003348)1.84504320
121Small intestinal stenosis (HP:0012848)1.83514152
122Duodenal stenosis (HP:0100867)1.83514152
123Dialeptic seizures (HP:0011146)1.83124802
124Poor speech (HP:0002465)1.82758380
125Enlarged kidneys (HP:0000105)1.82214501
126Constricted visual fields (HP:0001133)1.82166702
127Abnormality of renal resorption (HP:0011038)1.82148344
128Septo-optic dysplasia (HP:0100842)1.82000393
129Cerebral edema (HP:0002181)1.81993015
130Abnormality of the pancreatic islet cells (HP:0006476)1.81980964
131Abnormality of endocrine pancreas physiology (HP:0012093)1.81980964
132Abnormality of serum amino acid levels (HP:0003112)1.80862318
133Acute encephalopathy (HP:0006846)1.80774345
134Optic nerve hypoplasia (HP:0000609)1.80687732
135Ketoacidosis (HP:0001993)1.80372769
136Unsteady gait (HP:0002317)1.79604763
137Abnormality of the duodenum (HP:0002246)1.79519344
138Abnormal gallbladder physiology (HP:0012438)1.79337742
139Cholecystitis (HP:0001082)1.79337742
140Vitreoretinal degeneration (HP:0000655)1.79210543
141Pheochromocytoma (HP:0002666)1.79054295
142Birth length less than 3rd percentile (HP:0003561)1.78445268
143Lethargy (HP:0001254)1.78204767
144Scanning speech (HP:0002168)1.77969343
145Epileptiform EEG discharges (HP:0011182)1.77779900
146Pancreatic islet-cell hyperplasia (HP:0004510)1.76858721
147Astigmatism (HP:0000483)1.75496708
148Gaze-evoked nystagmus (HP:0000640)1.75399847
149Exercise intolerance (HP:0003546)1.75354195
150Hyperlipoproteinemia (HP:0010980)1.75282206
151Abnormality of the pons (HP:0007361)1.74862967
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73778674
153Neoplasm of the liver (HP:0002896)1.73352842
154Impaired vibration sensation in the lower limbs (HP:0002166)1.73332291
155EEG with generalized epileptiform discharges (HP:0011198)1.73281197
156Generalized tonic-clonic seizures (HP:0002069)1.73095057
157Neuroendocrine neoplasm (HP:0100634)1.72913402
158Tubular atrophy (HP:0000092)1.72906503
159Limb hypertonia (HP:0002509)1.72902451
160Oligodactyly (hands) (HP:0001180)1.72515464
161Exertional dyspnea (HP:0002875)1.72162764
162Pancreatic fibrosis (HP:0100732)1.72071614
163Abnormality of serine family amino acid metabolism (HP:0010894)1.71717292
164Abnormality of glycine metabolism (HP:0010895)1.71717292
165Aganglionic megacolon (HP:0002251)1.71459654
166Acute necrotizing encephalopathy (HP:0006965)1.71325815
167Microvesicular hepatic steatosis (HP:0001414)1.70800137
168Abnormality of the carotid arteries (HP:0005344)1.69409984
169Absent thumb (HP:0009777)1.68085917
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.67845922
171Hepatocellular necrosis (HP:0001404)1.67755397
172Furrowed tongue (HP:0000221)1.66994451
173Postaxial hand polydactyly (HP:0001162)1.66544515
174Broad foot (HP:0001769)1.65106636
175Leukodystrophy (HP:0002415)1.64425379
176Truncal ataxia (HP:0002078)1.64401982
177Status epilepticus (HP:0002133)1.64278712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB13.92016008
2NEK13.36591435
3PRPF4B3.32687189
4FRK3.25448697
5BMPR1B2.76228382
6BCKDK2.72270099
7CASK2.46791121
8STK162.46751694
9ZAK2.42831151
10EIF2AK12.41207044
11VRK22.38431667
12AKT32.16721778
13MAP2K42.16321416
14NUAK12.13366360
15SIK32.02620445
16PLK41.95058584
17MAP2K71.92394559
18MAP3K41.91102968
19MAP4K21.89813065
20PINK11.85901972
21BUB11.85079033
22WNK41.84310697
23MKNK21.77226767
24TSSK61.76989811
25BCR1.69908191
26MST41.67039221
27MAP3K121.64744515
28KSR11.61244876
29BRD41.60835113
30MARK11.60119923
31PDK41.58761247
32PDK31.58761247
33STK391.51341555
34CDK191.48217058
35YES11.45056483
36MKNK11.44413773
37SRPK11.42449781
38ADRBK21.41246258
39ACVR1B1.38135897
40PLK31.33715784
41OXSR11.33239226
42TTK1.33103120
43TAF11.32153738
44NEK21.27853498
45MINK11.27757193
46PAK31.27151353
47PNCK1.25618171
48TLK11.25030479
49PASK1.24383721
50NTRK21.20906860
51CDC71.20898458
52TAOK21.17220672
53DAPK11.17159169
54SGK2231.17030166
55SGK4941.17030166
56BRSK21.14957507
57SGK21.14414579
58FGFR21.14221697
59UHMK11.12800372
60EPHA41.11705260
61BRSK11.07418437
62TRIM281.06858537
63CSNK1G11.06565433
64PBK1.02882380
65MUSK1.02414372
66PAK61.00862124
67WNK31.00822431
68PHKG20.98090559
69PHKG10.98090559
70DYRK30.97105148
71EPHA30.94375597
72NTRK30.93564410
73PLK20.93310134
74STK38L0.90801951
75WEE10.90153557
76CDK30.87533179
77CAMK2B0.87415857
78PRKCG0.86802484
79TAOK30.86446559
80NME10.85329459
81DYRK1A0.83389034
82CDK80.83366389
83SCYL20.81638880
84VRK10.80873528
85DAPK20.79274010
86ATR0.77540775
87GRK10.76482911
88TNIK0.72940018
89CAMK2G0.72695013
90INSRR0.72561843
91EIF2AK20.71425469
92TGFBR10.71258950
93MAP2K60.70522218
94MAPK130.68585591
95RPS6KB10.68457066
96CSNK1A1L0.67684633
97CDK180.66928879
98PRKCE0.66550865
99CAMK2D0.63350497
100PDK20.63221405
101ERBB30.61679243
102PKN10.61292578
103EIF2AK30.59948527
104OBSCN0.59827268
105ADRBK10.58960574
106MAPKAPK50.58541947
107ATM0.58206793
108STK30.57733882
109BRAF0.57313184
110PLK10.56331738
111CHEK20.56178020
112CSNK1G20.55873130
113NEK60.55558016
114AURKB0.54113372
115SGK30.53950776
116PRKACB0.53346860
117DYRK20.52809228
118CSNK1G30.52503021
119PRKCZ0.52239996
120CDK150.52167885
121CDK140.51905262
122CAMK2A0.51622167
123CDK10.50440403
124MAP2K30.49474261
125CAMKK20.48543593
126MAP3K90.45770566
127CSNK2A10.43853514
128FGFR40.43743765
129FLT30.43054935
130CDK11A0.42919319
131CSNK2A20.42010207
132MAPK100.40247498
133CDK20.40103968
134CSNK1E0.40010536
135RPS6KA50.39811803
136CHEK10.39709563
137PRKACA0.39134158
138MAPK70.38192114
139TIE10.37998916
140CSNK1A10.35623746
141CAMK10.35039274
142PRKCI0.34762023
143AURKA0.33219522

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.91170554
2Parkinsons disease_Homo sapiens_hsa050122.89877466
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78324734
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.61650262
5Protein export_Homo sapiens_hsa030602.48730073
6Ribosome_Homo sapiens_hsa030102.30399017
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18351838
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16110206
9Nicotine addiction_Homo sapiens_hsa050332.15555315
10Huntingtons disease_Homo sapiens_hsa050162.10246890
11Synaptic vesicle cycle_Homo sapiens_hsa047212.06949083
12Mismatch repair_Homo sapiens_hsa034302.03079649
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00713437
14Butanoate metabolism_Homo sapiens_hsa006501.91958980
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91920575
16Alzheimers disease_Homo sapiens_hsa050101.91668893
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85679237
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.84644935
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.83743180
20Propanoate metabolism_Homo sapiens_hsa006401.78802254
21Pyruvate metabolism_Homo sapiens_hsa006201.77446440
22Biosynthesis of amino acids_Homo sapiens_hsa012301.76459899
23Base excision repair_Homo sapiens_hsa034101.70601521
24Arginine biosynthesis_Homo sapiens_hsa002201.68976387
25DNA replication_Homo sapiens_hsa030301.61663249
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57614040
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54619548
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54003494
29Carbon metabolism_Homo sapiens_hsa012001.53528806
30GABAergic synapse_Homo sapiens_hsa047271.48745756
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.48416282
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47235000
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38615502
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32224118
35Peroxisome_Homo sapiens_hsa041461.31709366
36Nucleotide excision repair_Homo sapiens_hsa034201.26237675
37Folate biosynthesis_Homo sapiens_hsa007901.25325252
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24067998
39One carbon pool by folate_Homo sapiens_hsa006701.22267650
40Selenocompound metabolism_Homo sapiens_hsa004501.19898581
41Proteasome_Homo sapiens_hsa030501.19119001
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15203320
43Steroid biosynthesis_Homo sapiens_hsa001001.14052239
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12779941
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11675300
46Vitamin B6 metabolism_Homo sapiens_hsa007501.08855048
47Collecting duct acid secretion_Homo sapiens_hsa049661.08739933
48Olfactory transduction_Homo sapiens_hsa047401.06343574
49Morphine addiction_Homo sapiens_hsa050321.04894246
50Fatty acid elongation_Homo sapiens_hsa000621.03396780
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00332673
52Fatty acid metabolism_Homo sapiens_hsa012120.99173780
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97081280
54Fatty acid degradation_Homo sapiens_hsa000710.94585777
55Fructose and mannose metabolism_Homo sapiens_hsa000510.92474352
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.92307992
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92075282
58Spliceosome_Homo sapiens_hsa030400.91786267
59Tryptophan metabolism_Homo sapiens_hsa003800.90593014
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90285263
61Lysine degradation_Homo sapiens_hsa003100.88959941
62Linoleic acid metabolism_Homo sapiens_hsa005910.88952454
63Homologous recombination_Homo sapiens_hsa034400.86942737
64Phenylalanine metabolism_Homo sapiens_hsa003600.84649221
65Retinol metabolism_Homo sapiens_hsa008300.84184834
66Circadian entrainment_Homo sapiens_hsa047130.80571458
67Insulin secretion_Homo sapiens_hsa049110.79232256
68Taste transduction_Homo sapiens_hsa047420.76803859
69Pyrimidine metabolism_Homo sapiens_hsa002400.76244576
70Sulfur metabolism_Homo sapiens_hsa009200.75989671
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75910146
72RNA transport_Homo sapiens_hsa030130.75198190
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.75176910
74Purine metabolism_Homo sapiens_hsa002300.73862009
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73776795
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73078011
77Dopaminergic synapse_Homo sapiens_hsa047280.71079119
78Pentose phosphate pathway_Homo sapiens_hsa000300.70606811
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68469848
80Vibrio cholerae infection_Homo sapiens_hsa051100.66047475
81beta-Alanine metabolism_Homo sapiens_hsa004100.65488483
82Tyrosine metabolism_Homo sapiens_hsa003500.65125627
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63658833
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63477006
85Cell cycle_Homo sapiens_hsa041100.63228140
86Fanconi anemia pathway_Homo sapiens_hsa034600.63091195
87Basal transcription factors_Homo sapiens_hsa030220.61895029
88RNA polymerase_Homo sapiens_hsa030200.59559557
89Oocyte meiosis_Homo sapiens_hsa041140.59083617
90Caffeine metabolism_Homo sapiens_hsa002320.58774986
91Metabolic pathways_Homo sapiens_hsa011000.57790521
92Non-homologous end-joining_Homo sapiens_hsa034500.56382298
93Ether lipid metabolism_Homo sapiens_hsa005650.56337830
94Glutathione metabolism_Homo sapiens_hsa004800.56048462
95Sulfur relay system_Homo sapiens_hsa041220.55725300
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55323425
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.55035256
98mRNA surveillance pathway_Homo sapiens_hsa030150.54631798
99Nitrogen metabolism_Homo sapiens_hsa009100.54346791
100Regulation of autophagy_Homo sapiens_hsa041400.53783917
101ABC transporters_Homo sapiens_hsa020100.53660595
102Complement and coagulation cascades_Homo sapiens_hsa046100.53108094
103Chemical carcinogenesis_Homo sapiens_hsa052040.51533304
104Arginine and proline metabolism_Homo sapiens_hsa003300.49444016
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48954223
106Amphetamine addiction_Homo sapiens_hsa050310.48853052
107Oxidative phosphorylation_Homo sapiens_hsa001900.48411545
108Glutamatergic synapse_Homo sapiens_hsa047240.48107866
109Bile secretion_Homo sapiens_hsa049760.47853425
110Serotonergic synapse_Homo sapiens_hsa047260.47154404
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46661152
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45650314
113Circadian rhythm_Homo sapiens_hsa047100.42362358
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41931390
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41754111
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40969444
117Hedgehog signaling pathway_Homo sapiens_hsa043400.40401256
118N-Glycan biosynthesis_Homo sapiens_hsa005100.40055856
119RNA degradation_Homo sapiens_hsa030180.39577449
120Cardiac muscle contraction_Homo sapiens_hsa042600.36822638
121Alcoholism_Homo sapiens_hsa050340.35721950
122Basal cell carcinoma_Homo sapiens_hsa052170.34519593
123Calcium signaling pathway_Homo sapiens_hsa040200.30241571
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28861892

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