ADAM12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gonadotropin secretion (GO:0032276)6.34218530
2response to follicle-stimulating hormone (GO:0032354)6.27910546
3female pregnancy (GO:0007565)5.70802058
4estrogen metabolic process (GO:0008210)5.30747334
5chondrocyte proliferation (GO:0035988)4.95797674
6collagen fibril organization (GO:0030199)4.93687881
7sequestering of extracellular ligand from receptor (GO:0035581)4.93595892
8protein heterotrimerization (GO:0070208)4.82805601
9glucocorticoid biosynthetic process (GO:0006704)4.74002074
10prostate gland growth (GO:0060736)4.67687769
11mesenchymal-epithelial cell signaling (GO:0060638)4.64889231
12bone trabecula formation (GO:0060346)4.45143594
13axon extension involved in axon guidance (GO:0048846)4.31475812
14neuron projection extension involved in neuron projection guidance (GO:1902284)4.31475812
15retina vasculature morphogenesis in camera-type eye (GO:0061299)4.23434786
16multi-multicellular organism process (GO:0044706)4.19843131
17vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.86936819
18endodermal cell differentiation (GO:0035987)3.75976294
19androgen biosynthetic process (GO:0006702)3.71471203
20multi-organism reproductive process (GO:0044703)3.65420436
21type B pancreatic cell proliferation (GO:0044342)3.55859811
22extracellular negative regulation of signal transduction (GO:1900116)3.48356524
23extracellular regulation of signal transduction (GO:1900115)3.48356524
24positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.47071472
25chondrocyte development (GO:0002063)3.40550316
26endocrine hormone secretion (GO:0060986)3.38904021
27cell adhesion mediated by integrin (GO:0033627)3.38549657
28basement membrane organization (GO:0071711)3.35466897
29adhesion of symbiont to host cell (GO:0044650)3.35207623
30virion attachment to host cell (GO:0019062)3.35207623
31regulation of integrin-mediated signaling pathway (GO:2001044)3.35093680
32collagen catabolic process (GO:0030574)3.34764667
33collagen metabolic process (GO:0032963)3.33975457
34ganglion development (GO:0061548)3.33278167
35blood vessel maturation (GO:0001955)3.29692750
36dermatan sulfate biosynthetic process (GO:0030208)3.29576527
37wound healing, spreading of epidermal cells (GO:0035313)3.27434216
38negative regulation of smooth muscle cell migration (GO:0014912)3.22155039
39regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.21086246
40vascular endothelial growth factor signaling pathway (GO:0038084)3.19804129
41substrate-dependent cell migration (GO:0006929)3.16776525
42lymphangiogenesis (GO:0001946)3.15707081
43multicellular organismal macromolecule metabolic process (GO:0044259)3.15389194
44androgen metabolic process (GO:0008209)3.14448351
45substrate adhesion-dependent cell spreading (GO:0034446)3.13679294
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.13360542
47regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.09965404
48limb bud formation (GO:0060174)3.09000676
49cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.07700992
50endothelial cell morphogenesis (GO:0001886)3.07554763
51apoptotic cell clearance (GO:0043277)3.07018707
52negative regulation of activin receptor signaling pathway (GO:0032926)3.06841818
53positive regulation of osteoblast proliferation (GO:0033690)3.04480749
54cell migration involved in sprouting angiogenesis (GO:0002042)3.04344164
55heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.03821148
56positive regulation of growth hormone secretion (GO:0060124)3.03446296
57positive regulation of blood vessel endothelial cell migration (GO:0043536)3.01518105
58multicellular organismal catabolic process (GO:0044243)3.00050441
59dermatan sulfate metabolic process (GO:0030205)2.99424438
60paraxial mesoderm development (GO:0048339)2.99007854
61sprouting angiogenesis (GO:0002040)2.97667141
62positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.96183830
63multicellular organismal metabolic process (GO:0044236)2.95598066
64adhesion of symbiont to host (GO:0044406)2.95199162
65smooth muscle tissue development (GO:0048745)2.94429495
66cellular response to vitamin D (GO:0071305)2.93481840
67negative regulation of BMP signaling pathway (GO:0030514)2.92178551
68positive regulation of axon extension (GO:0045773)2.91170809
69positive regulation of cartilage development (GO:0061036)2.90922569
70craniofacial suture morphogenesis (GO:0097094)2.90545304
71negative regulation of chondrocyte differentiation (GO:0032331)2.89417414
72protein retention in ER lumen (GO:0006621)2.85398534
73glomerular basement membrane development (GO:0032836)2.84971613
74glucocorticoid metabolic process (GO:0008211)2.83067870
75negative regulation of axon extension involved in axon guidance (GO:0048843)2.81156669
76venous blood vessel morphogenesis (GO:0048845)2.80995205
77regulation of non-canonical Wnt signaling pathway (GO:2000050)2.79575601
78extracellular matrix disassembly (GO:0022617)2.79052301
79response to gonadotropin (GO:0034698)2.78500742
80cell-substrate junction assembly (GO:0007044)2.78216024
81regulation of cartilage development (GO:0061035)2.76865462
82extracellular fibril organization (GO:0043206)2.75679737
83cellular response to vitamin (GO:0071295)2.75418608
84metanephric mesenchyme development (GO:0072075)2.74933188
85positive regulation of endothelial cell apoptotic process (GO:2000353)2.74377905
86regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.74256584
87blood vessel morphogenesis (GO:0048514)2.72555802
88chondroitin sulfate biosynthetic process (GO:0030206)2.72297357
89cell proliferation in forebrain (GO:0021846)2.72282360
90daunorubicin metabolic process (GO:0044597)2.71292230
91polyketide metabolic process (GO:0030638)2.71292230
92doxorubicin metabolic process (GO:0044598)2.71292230
93tooth mineralization (GO:0034505)2.70754999
94glomerular filtration (GO:0003094)2.70563650
95stress fiber assembly (GO:0043149)2.69952813
96regulation of mesenchymal cell proliferation (GO:0010464)2.68917559
97peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.68329362
98barbed-end actin filament capping (GO:0051016)2.68070234
99extracellular matrix assembly (GO:0085029)2.66715924
100protein localization to cell surface (GO:0034394)2.64732257
101negative chemotaxis (GO:0050919)2.64450107
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64343741
103keratan sulfate catabolic process (GO:0042340)2.64085601
104negative regulation of catenin import into nucleus (GO:0035414)2.63812858
105regulation of osteoblast proliferation (GO:0033688)2.62283152
106positive regulation of mesenchymal cell proliferation (GO:0002053)2.61909393
107mesenchymal cell differentiation (GO:0048762)2.60859857
108hippo signaling (GO:0035329)2.60517020
109peptidyl-proline hydroxylation (GO:0019511)2.60370718
110extracellular matrix organization (GO:0030198)2.58952153
111embryonic cranial skeleton morphogenesis (GO:0048701)2.58585295
112extracellular structure organization (GO:0043062)2.57758907
113cartilage morphogenesis (GO:0060536)2.56696036
114kidney mesenchyme development (GO:0072074)2.55453508
115lymph vessel development (GO:0001945)2.55155902
116cell migration involved in heart development (GO:0060973)2.54493836
117embryonic camera-type eye development (GO:0031076)2.54385515
118renal filtration (GO:0097205)2.53673361
119negative regulation of embryonic development (GO:0045992)2.52997478
120semaphorin-plexin signaling pathway (GO:0071526)2.52521045
121cerebral cortex radially oriented cell migration (GO:0021799)2.51234614
122artery development (GO:0060840)2.49820721
123face morphogenesis (GO:0060325)2.48780617
124skin morphogenesis (GO:0043589)2.47831421
125lateral sprouting from an epithelium (GO:0060601)2.46160010
126somatic stem cell division (GO:0048103)2.45999329
127facial nerve structural organization (GO:0021612)2.43755886
128wound healing, spreading of cells (GO:0044319)2.43683008
129negative regulation of cartilage development (GO:0061037)2.41858869
130insulin-like growth factor receptor signaling pathway (GO:0048009)2.41676130
131mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.41024793
132planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40363576
133radial glial cell differentiation (GO:0060019)2.39495609
134regulation of chondrocyte differentiation (GO:0032330)2.38888760
135cardiac epithelial to mesenchymal transition (GO:0060317)2.38576230
136negative regulation of stem cell proliferation (GO:2000647)2.38246541
137cellular response to BMP stimulus (GO:0071773)2.37363121
138response to BMP (GO:0071772)2.37363121
139negative regulation of keratinocyte proliferation (GO:0010839)2.37111878
140mesodermal cell differentiation (GO:0048333)2.36414884
141regulation of axon extension involved in axon guidance (GO:0048841)2.35560833
142positive regulation of smooth muscle cell migration (GO:0014911)2.34625246
143cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.34582021
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34045710
145regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.33604989
146epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.32867767
147positive regulation of protein kinase C signaling (GO:0090037)2.32650991
148fibril organization (GO:0097435)2.32592192
149estrogen biosynthetic process (GO:0006703)11.3316780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.63704966
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.34830668
3GBX2_23144817_ChIP-Seq_PC3_Human3.24563185
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.65753610
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.50745566
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39499732
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.31696058
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.27089886
9EZH2_22144423_ChIP-Seq_EOC_Human2.24926980
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.21986914
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19635587
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19326040
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.14289265
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12996805
15EGR1_19032775_ChIP-ChIP_M12_Human2.12953177
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11955411
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11955411
18* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11160755
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.08206332
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05916638
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97940269
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97591175
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97411182
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.97237766
25* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.96465113
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95535827
27* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95154113
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89676774
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88264404
30* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.86073634
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83538960
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.83242882
33TP53_18474530_ChIP-ChIP_U2OS_Human1.80714256
34AR_21572438_ChIP-Seq_LNCaP_Human1.80036107
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79031463
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.78457865
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78057623
38* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73521892
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67986280
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67618867
41* RNF2_27304074_Chip-Seq_ESCs_Mouse1.61262126
42* CJUN_26792858_Chip-Seq_BT549_Human1.60353653
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58584590
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58467448
45* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57527409
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54023861
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53567497
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.51412776
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49200778
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48583971
51CLOCK_20551151_ChIP-Seq_293T_Human1.48304020
52* P300_19829295_ChIP-Seq_ESCs_Human1.46336516
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45063253
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44486129
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43317263
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.42750624
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41112541
58* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40548648
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.38945446
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.37479531
61SMAD4_21799915_ChIP-Seq_A2780_Human1.37417681
62TP53_16413492_ChIP-PET_HCT116_Human1.36324605
63SMC1_22415368_ChIP-Seq_MEFs_Mouse1.36316173
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35411088
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35411088
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34767526
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.34110743
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.32309013
69* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31661288
70FUS_26573619_Chip-Seq_HEK293_Human1.31400884
71* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30860727
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30283918
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29223348
74* SA1_22415368_ChIP-Seq_MEFs_Mouse1.28979272
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.28706242
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27125638
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27125638
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26895998
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26892857
80* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26550037
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26536678
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.26457075
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26242023
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25674806
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25471333
86* DROSHA_22980978_ChIP-Seq_HELA_Human1.25212922
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23966663
88* BRD4_25478319_ChIP-Seq_HGPS_Human1.23403086
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23190421
90IGF1R_20145208_ChIP-Seq_DFB_Human1.22654462
91* ARNT_22903824_ChIP-Seq_MCF-7_Human1.22350673
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21322319
93* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21182695
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.21140079
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.19410611
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.19183057
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18755968
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.18096656
99TAF15_26573619_Chip-Seq_HEK293_Human1.17378605
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13673324
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13577819
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.13483497
103RUNX2_22187159_ChIP-Seq_PCA_Human1.13350906
104* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13325912
105STAT3_23295773_ChIP-Seq_U87_Human1.12976555
106* AHR_22903824_ChIP-Seq_MCF-7_Human1.12271933
107* UBF1/2_26484160_Chip-Seq_HMECs_Human1.12228685
108P53_22387025_ChIP-Seq_ESCs_Mouse1.11980048
109ER_23166858_ChIP-Seq_MCF-7_Human1.11784756
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10809777
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10742847
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.10364950
113BCAT_22108803_ChIP-Seq_LS180_Human1.08154122
114SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07790155
115TP63_23658742_ChIP-Seq_EP156T_Human1.07405422
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07027743
117TBX20_22080862_ChIP-Seq_HEART_Mouse1.06590860
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.06590860
119TP53_22127205_ChIP-Seq_IMR90_Human1.06403548
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06382809
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06078418
122* ISL1_27105846_Chip-Seq_CPCs_Mouse1.05753338
123P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04425739
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04035577
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.03516822
126TP53_23651856_ChIP-Seq_MEFs_Mouse1.03115061
127* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02217359
128* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01960526
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01872445
130SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01174154
131TCF4_23295773_ChIP-Seq_U87_Human1.00770585
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00758874
133AR_25329375_ChIP-Seq_VCAP_Human1.00517956
134SMAD3_21741376_ChIP-Seq_HESCs_Human1.00352899
135GATA2_21666600_ChIP-Seq_HMVEC_Human1.00274640
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99946411
137* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98218292
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97609639
139SOX2_20726797_ChIP-Seq_SW620_Human0.96845955
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94995914
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93976987
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92639533
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91962131
144ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91400267
145* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90645662
146* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90629593
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89891728
148VDR_24787735_ChIP-Seq_THP-1_Human0.89178714
149SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88404074
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85244311
151* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84796107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.60436478
2MP0005503_abnormal_tendon_morphology4.60566330
3MP0005275_abnormal_skin_tensile3.90812257
4MP0004272_abnormal_basement_membrane3.64059517
5MP0005171_absent_coat_pigmentation3.40180190
6MP0009697_abnormal_copulation3.20494382
7MP0003279_aneurysm3.08229609
8MP0005623_abnormal_meninges_morphology2.84301911
9MP0001958_emphysema2.45482397
10MP0009250_abnormal_appendicular_skeleto2.34859959
11MP0005257_abnormal_intraocular_pressure2.31225846
12MP0000566_synostosis2.28151281
13MP0010368_abnormal_lymphatic_system2.23074517
14MP0003941_abnormal_skin_development2.18497524
15MP0002102_abnormal_ear_morphology2.07972038
16MP0003705_abnormal_hypodermis_morpholog2.03486665
17MP0003385_abnormal_body_wall2.03075577
18MP0005508_abnormal_skeleton_morphology2.00492568
19MP0009384_cardiac_valve_regurgitation1.96806721
20MP0004134_abnormal_chest_morphology1.91373751
21MP0001879_abnormal_lymphatic_vessel1.91030270
22MP0002108_abnormal_muscle_morphology1.72026324
23MP0002060_abnormal_skin_morphology1.70514511
24MP0002249_abnormal_larynx_morphology1.70351152
25MP0003136_yellow_coat_color1.63631547
26MP0010030_abnormal_orbit_morphology1.62036405
27MP0002163_abnormal_gland_morphology1.60996975
28MP0000569_abnormal_digit_pigmentation1.58414930
29MP0001188_hyperpigmentation1.52503394
30MP0003091_abnormal_cell_migration1.47642099
31MP0003937_abnormal_limbs/digits/tail_de1.47493504
32MP0006054_spinal_hemorrhage1.45251395
33MP0003566_abnormal_cell_adhesion1.43766523
34MP0000049_abnormal_middle_ear1.39995361
35MP0005248_abnormal_Harderian_gland1.39727365
36MP0001299_abnormal_eye_distance/1.39243437
37MP0000767_abnormal_smooth_muscle1.37518132
38MP0000163_abnormal_cartilage_morphology1.36090919
39MP0002896_abnormal_bone_mineralization1.35712890
40MP0003045_fibrosis1.35491523
41MP0010386_abnormal_urinary_bladder1.35123548
42MP0003755_abnormal_palate_morphology1.33809224
43MP0006276_abnormal_autonomic_nervous1.32795124
44MP0000372_irregular_coat_pigmentation1.30367897
45MP0002938_white_spotting1.29951657
46MP0002233_abnormal_nose_morphology1.24606016
47MP0003935_abnormal_craniofacial_develop1.24546465
48MP0000751_myopathy1.22858399
49MP0009780_abnormal_chondrocyte_physiolo1.22847558
50MP0002295_abnormal_pulmonary_circulatio1.20449651
51MP0000432_abnormal_head_morphology1.18899070
52MP0002115_abnormal_skeleton_extremities1.18145473
53MP0002109_abnormal_limb_morphology1.17118910
54MP0001542_abnormal_bone_strength1.16362081
55MP0003122_maternal_imprinting1.15750310
56MP0002932_abnormal_joint_morphology1.15659503
57MP0000762_abnormal_tongue_morphology1.15310089
58MP0005670_abnormal_white_adipose1.15008593
59MP0003942_abnormal_urinary_system1.13899924
60MP0000733_abnormal_muscle_development1.13242914
61MP0002177_abnormal_outer_ear1.12475554
62MP0002282_abnormal_trachea_morphology1.10816626
63MP0004858_abnormal_nervous_system1.10165258
64MP0002113_abnormal_skeleton_development1.09077788
65MP0002116_abnormal_craniofacial_bone1.08991583
66MP0005377_hearing/vestibular/ear_phenot1.08788898
67MP0003878_abnormal_ear_physiology1.08788898
68MP0000383_abnormal_hair_follicle1.05392124
69MP0002998_abnormal_bone_remodeling1.05099430
70MP0003959_abnormal_lean_body1.01495571
71MP0003950_abnormal_plasma_membrane1.00365457
72MP0005409_darkened_coat_color0.99811633
73MP0005379_endocrine/exocrine_gland_phen0.97942373
74MP0001346_abnormal_lacrimal_gland0.97828130
75MP0005390_skeleton_phenotype0.97174065
76MP0002697_abnormal_eye_size0.96804383
77MP0000428_abnormal_craniofacial_morphol0.94458113
78MP0002168_other_aberrant_phenotype0.93778991
79MP0003115_abnormal_respiratory_system0.93511761
80MP0005595_abnormal_vascular_smooth0.93329933
81MP0005647_abnormal_sex_gland0.91342149
82MP0000537_abnormal_urethra_morphology0.85789303
83MP0003448_altered_tumor_morphology0.85502846
84MP0009053_abnormal_anal_canal0.84323121
85MP0000013_abnormal_adipose_tissue0.82617629
86MP0001915_intracranial_hemorrhage0.82455869
87MP0000003_abnormal_adipose_tissue0.79328901
88MP0000427_abnormal_hair_cycle0.79193487
89MP0005023_abnormal_wound_healing0.78692445
90MP0005388_respiratory_system_phenotype0.77776191
91MP0002133_abnormal_respiratory_system0.77776191
92MP0000534_abnormal_ureter_morphology0.77399453
93MP0002114_abnormal_axial_skeleton0.77145799
94MP0004084_abnormal_cardiac_muscle0.76885803
95MP0000516_abnormal_urinary_system0.76649334
96MP0005367_renal/urinary_system_phenotyp0.76649334
97MP0005197_abnormal_uvea_morphology0.76342689
98MP0002111_abnormal_tail_morphology0.75485896
99MP0001243_abnormal_dermal_layer0.74758494
100MP0004381_abnormal_hair_follicle0.74034296
101MP0005164_abnormal_response_to0.72150437
102* MP0000759_abnormal_skeletal_muscle0.70979796
103MP0003938_abnormal_ear_development0.70879660
104MP0006138_congestive_heart_failure0.70653027
105MP0000749_muscle_degeneration0.70044452
106MP0001614_abnormal_blood_vessel0.69769548
107MP0003283_abnormal_digestive_organ0.68834471
108MP0005645_abnormal_hypothalamus_physiol0.68604987
109MP0005193_abnormal_anterior_eye0.67913182
110MP0010352_gastrointestinal_tract_polyps0.67565712
111MP0002128_abnormal_blood_circulation0.67108107
112MP0002925_abnormal_cardiovascular_devel0.65753731
113MP0001849_ear_inflammation0.65470515
114MP0000613_abnormal_salivary_gland0.64760791
115MP0000343_altered_response_to0.64687051
116MP0001348_abnormal_lacrimal_gland0.64545726
117MP0001177_atelectasis0.63893027
118MP0010678_abnormal_skin_adnexa0.61815641
119MP0000579_abnormal_nail_morphology0.61678795
120MP0003828_pulmonary_edema0.60714889
121MP0002933_joint_inflammation0.60602771
122MP0002877_abnormal_melanocyte_morpholog0.59669595
123MP0005375_adipose_tissue_phenotype0.59014509
124MP0003795_abnormal_bone_structure0.58552342
125MP0001440_abnormal_grooming_behavior0.57296586
126MP0003936_abnormal_reproductive_system0.55808845
127MP0005165_increased_susceptibility_to0.54061323
128MP0003300_gastrointestinal_ulcer0.53282371
129MP0000230_abnormal_systemic_arterial0.52840729
130MP0001919_abnormal_reproductive_system0.52788768
131MP0004233_abnormal_muscle_weight0.51692754
132MP0000462_abnormal_digestive_system0.51655505
133MP0009115_abnormal_fat_cell0.50989328
134MP0001175_abnormal_lung_morphology0.50792949

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.55531945
2Protrusio acetabuli (HP:0003179)5.89219793
3Atrophic scars (HP:0001075)4.63537484
4Aortic dissection (HP:0002647)4.05438914
5Follicular hyperkeratosis (HP:0007502)4.02261452
6Abnormality of dentin (HP:0010299)3.95463635
7Soft skin (HP:0000977)3.85728593
8Shallow orbits (HP:0000586)3.71765923
9Fragile skin (HP:0001030)3.65199391
10Neonatal short-limb short stature (HP:0008921)3.44236036
11Broad metatarsal (HP:0001783)3.43539402
12Bladder diverticulum (HP:0000015)3.27196140
13Ankle contracture (HP:0006466)3.02222945
14Peritonitis (HP:0002586)2.95974820
15Nonimmune hydrops fetalis (HP:0001790)2.94941931
16Hypoplasia of the iris (HP:0007676)2.83516614
17Genu recurvatum (HP:0002816)2.80668852
18Morphological abnormality of the middle ear (HP:0008609)2.79152961
19Mitral stenosis (HP:0001718)2.76317831
20Aortic aneurysm (HP:0004942)2.68663677
21Increased variability in muscle fiber diameter (HP:0003557)2.67226376
22Blue sclerae (HP:0000592)2.65978050
23Disproportionate tall stature (HP:0001519)2.61376570
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.58681023
25Osteolytic defects of the hand bones (HP:0009699)2.58681023
26Wormian bones (HP:0002645)2.58670144
27Mesomelia (HP:0003027)2.57814399
28Dilatation of the ascending aorta (HP:0005111)2.52205553
29Bell-shaped thorax (HP:0001591)2.52070446
30Aortic valve stenosis (HP:0001650)2.49768688
31Round ear (HP:0100830)2.46912778
32Thin bony cortex (HP:0002753)2.41906804
33Spinal rigidity (HP:0003306)2.39752053
34Abnormality of the acetabulum (HP:0003170)2.39390276
35Cerebral aneurysm (HP:0004944)2.39200844
36Aplasia cutis congenita (HP:0001057)2.38795876
37Coronal craniosynostosis (HP:0004440)2.35542643
38Joint stiffness (HP:0001387)2.34990606
39Mitral valve prolapse (HP:0001634)2.34081033
40Asymmetry of the thorax (HP:0001555)2.33413725
41Abnormality of incisor morphology (HP:0011063)2.31433656
42Mildly elevated creatine phosphokinase (HP:0008180)2.29877241
43Abnormality of the nasal septum (HP:0000419)2.29679912
44Mild short stature (HP:0003502)2.26473110
45Venous abnormality (HP:0002624)2.25831304
46Aneurysm (HP:0002617)2.25023709
47Delayed gross motor development (HP:0002194)2.24476719
48Hyperextensible skin (HP:0000974)2.22196484
49Cardiovascular calcification (HP:0011915)2.22024626
50Type 1 muscle fiber predominance (HP:0003803)2.21836822
51Short 4th metacarpal (HP:0010044)2.21529311
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21529311
53Wide anterior fontanel (HP:0000260)2.20374873
54Pulmonary artery stenosis (HP:0004415)2.19986393
55Broad ribs (HP:0000885)2.19967344
56Tibial bowing (HP:0002982)2.19834051
57Hypoventilation (HP:0002791)2.19687761
58Overgrowth (HP:0001548)2.19214916
59Abnormality of skeletal muscle fiber size (HP:0012084)2.19055972
60Wrist flexion contracture (HP:0001239)2.17252523
61Biconcave vertebral bodies (HP:0004586)2.13824735
62Ovoid vertebral bodies (HP:0003300)2.10381883
63Infantile muscular hypotonia (HP:0008947)2.10290914
64Cervical subluxation (HP:0003308)2.07799576
65Joint laxity (HP:0001388)2.05254486
66Slender build (HP:0001533)2.04808295
67Septo-optic dysplasia (HP:0100842)2.03890447
68Absent frontal sinuses (HP:0002688)2.03684940
69Bowel diverticulosis (HP:0005222)2.02841618
70Femoral bowing (HP:0002980)2.02253297
71Capillary hemangiomas (HP:0005306)2.01851913
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01323085
73Genu valgum (HP:0002857)2.01034907
74Upper limb muscle weakness (HP:0003484)2.00320748
75Midline defect of the nose (HP:0004122)1.98262476
76Back pain (HP:0003418)1.98059420
77Bilateral sensorineural hearing impairment (HP:0008619)1.97103514
78Renal duplication (HP:0000075)1.96673403
79Striae distensae (HP:0001065)1.96179588
80Limited hip movement (HP:0008800)1.95755160
81Vascular tortuosity (HP:0004948)1.95269051
82Increased corneal curvature (HP:0100692)1.95229757
83Keratoconus (HP:0000563)1.95229757
84Spinal cord lesions (HP:0100561)1.94618500
85Syringomyelia (HP:0003396)1.94618500
86Spondylolisthesis (HP:0003302)1.93613432
87Ulnar bowing (HP:0003031)1.93234852
88White forelock (HP:0002211)1.92149768
89Abnormal delivery (HP:0001787)1.92094805
90Inguinal hernia (HP:0000023)1.91549148
91Vertebral compression fractures (HP:0002953)1.89819957
92Cutaneous finger syndactyly (HP:0010554)1.88950235
93Submucous cleft hard palate (HP:0000176)1.86829926
94Deviation of the hallux (HP:0010051)1.86493679
95Ectopia lentis (HP:0001083)1.86035990
96Distal lower limb amyotrophy (HP:0008944)1.85633024
97Elbow flexion contracture (HP:0002987)1.84426810
98Camptodactyly of toe (HP:0001836)1.84233231
99Congenital glaucoma (HP:0001087)1.81708354
100Aplasia involving bones of the upper limbs (HP:0009823)1.81677583
101Aplasia of the phalanges of the hand (HP:0009802)1.81677583
102Aplasia involving bones of the extremities (HP:0009825)1.81677583
103Abnormality of the anterior chamber (HP:0000593)1.81378702
104Short nail (HP:0001799)1.81351744
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81204055
106Increased connective tissue (HP:0009025)1.80332231
107Knee flexion contracture (HP:0006380)1.78981567
108Hypoplastic ischia (HP:0003175)1.78664196
109Arterial tortuosity (HP:0005116)1.78535803
110Venous insufficiency (HP:0005293)1.77712045
111Protruding ear (HP:0000411)1.77269633
112Flared iliac wings (HP:0002869)1.75171455
113Flat cornea (HP:0007720)1.74414698
114Abnormality of the parietal bone (HP:0002696)1.74404065
115Delayed closure of the anterior fontanelle (HP:0001476)1.74276510
116Redundant skin (HP:0001582)1.74243890
117Chromsome breakage (HP:0040012)1.74063156
118Delayed cranial suture closure (HP:0000270)1.73699321
119Osteoarthritis (HP:0002758)1.73169937
120Hallux valgus (HP:0001822)1.72327993
121Alopecia of scalp (HP:0002293)1.69714659
122Breech presentation (HP:0001623)1.67679695
123Craniofacial hyperostosis (HP:0004493)1.66709056
124Buphthalmos (HP:0000557)1.65118297
125Patchy hypopigmentation of hair (HP:0011365)1.64551710
126Corneal dystrophy (HP:0001131)1.64407020
127Aortic regurgitation (HP:0001659)1.64054953
128Narrow nasal bridge (HP:0000446)1.63609641
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.63287538
130Mitral regurgitation (HP:0001653)1.63114552
131Broad long bones (HP:0005622)1.62415760
132Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61884464
133Flexion contracture of toe (HP:0005830)1.60765376
134Joint contractures involving the joints of the feet (HP:0100492)1.60765376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.37342864
2MYLK3.62348931
3CASK3.41047304
4SIK13.38525557
5DDR23.13945884
6EPHB22.89005219
7AKT32.56594669
8NTRK12.29402238
9LIMK12.26925443
10PDGFRA2.24145047
11INSRR2.16067295
12EPHA32.14384715
13CAMK1D2.09878457
14SIK32.08266605
15EIF2AK22.01184028
16NUAK11.96874902
17CAMK1G1.96386378
18TIE11.94374054
19TESK11.87178782
20FER1.67293570
21BMX1.65525782
22STK381.64294956
23DMPK1.62417190
24LATS21.61624260
25ICK1.59981996
26STK31.50095466
27ZAK1.49782896
28PIK3CA1.47444864
29TTN1.47422407
30FGFR21.47155230
31STK38L1.46278982
32KIT1.41798325
33MKNK21.41733676
34MET1.39109213
35PTK21.32912623
36MKNK11.31526003
37MST1R1.29077535
38RPS6KA21.28063809
39SIK21.28018677
40FGFR11.27301637
41PAK21.25720623
42PDGFRB1.25303375
43BMPR1B1.25272681
44FRK1.24333890
45PTK2B1.22339319
46PLK21.20601145
47TRIB31.12105867
48NEK61.11356747
49GRK11.10963632
50ERBB41.10419092
51FLT31.06759169
52TRPM71.06259545
53TGFBR21.05898703
54DAPK31.04857081
55MAP3K61.03936903
56PRKCE1.00369353
57MAP3K140.99171895
58BRD40.98839366
59KDR0.98649094
60ABL20.97770343
61ERN10.95595726
62TNIK0.93765937
63PRPF4B0.93116255
64ROCK10.91271154
65EPHA20.87131751
66PKN10.86395035
67ILK0.85518243
68CSNK1A1L0.84977256
69ERBB30.84227257
70PAK60.84125733
71PIK3CG0.83747478
72MARK30.83505241
73PRKAA20.82430438
74FGFR30.82268920
75PAK30.80972151
76PRKD30.79981254
77PTK60.79920157
78ADRBK20.79617519
79DAPK20.74792875
80IRAK10.72495021
81* INSR0.72282507
82YES10.72180995
83MAP2K10.71726366
84ROCK20.71269950
85BLK0.69425074
86JAK10.63514588
87TYK20.63046436
88CDC42BPA0.62670216
89MAPK130.62512013
90ADRBK10.62419980
91CHUK0.62319330
92ERBB20.61742005
93MARK20.61720537
94IGF1R0.61418252
95MAPK70.59446129
96WNK10.56354525
97PKN20.55971777
98MTOR0.55929651
99PRKD10.55673920
100NTRK30.54007191
101NEK90.53954608
102RPS6KL10.53388541
103RPS6KC10.53388541
104MAP3K30.53324829
105CLK10.53245397
106MAP3K70.52480445
107PRKD20.51239358
108MELK0.50584192
109EPHB10.49618037
110LMTK20.49186569
111TXK0.48898937
112RIPK10.48108070
113CDK90.46949272
114CDK120.43777202
115* SRC0.43429422
116CSNK1G10.42372867
117RPS6KA60.42309052
118CDK30.42172101
119PRKCH0.40490041
120PRKG20.40126318
121GSK3A0.38918093
122MAP3K130.38879999
123PDPK10.38712835
124PRKG10.38370237
125CDK80.37504122
126MAPK40.37413520
127MOS0.36660801
128CDK60.36053432
129BCR0.35082133
130STK240.34923436
131ABL10.34118201
132PAK40.34090806
133FGR0.33257817
134CAMK2G0.33107234
135MUSK0.32607174
136EGFR0.31090715
137MARK10.30623969
138JAK30.29858022
139ZAP700.28275453
140RET0.28113942
141MAPK110.25451842
142SCYL20.25046329
143MAPK10.24834881
144PIM20.21393342
145PAK10.20252980
146TGFBR10.16824499

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.92705304
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.68219212
3Focal adhesion_Homo sapiens_hsa045102.49213930
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.13176089
5Protein digestion and absorption_Homo sapiens_hsa049742.04814124
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.02222634
7Basal cell carcinoma_Homo sapiens_hsa052171.91643659
8Axon guidance_Homo sapiens_hsa043601.89104351
9Adherens junction_Homo sapiens_hsa045201.84334309
10Small cell lung cancer_Homo sapiens_hsa052221.76870828
11MicroRNAs in cancer_Homo sapiens_hsa052061.71515142
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70632094
13Dilated cardiomyopathy_Homo sapiens_hsa054141.65691883
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.65659430
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.62783925
16Melanoma_Homo sapiens_hsa052181.60149938
17Proteoglycans in cancer_Homo sapiens_hsa052051.59246410
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54063975
19Malaria_Homo sapiens_hsa051441.53750919
20Amoebiasis_Homo sapiens_hsa051461.46961316
21Hedgehog signaling pathway_Homo sapiens_hsa043401.42586901
22TGF-beta signaling pathway_Homo sapiens_hsa043501.41871039
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40408704
24Hippo signaling pathway_Homo sapiens_hsa043901.40257586
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.37312076
26Wnt signaling pathway_Homo sapiens_hsa043101.35211906
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33216768
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32241598
29N-Glycan biosynthesis_Homo sapiens_hsa005101.28841172
30Rap1 signaling pathway_Homo sapiens_hsa040151.19520566
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19388071
32Ovarian steroidogenesis_Homo sapiens_hsa049131.19078131
33Prostate cancer_Homo sapiens_hsa052151.17835179
34Pathways in cancer_Homo sapiens_hsa052001.12009931
35Ras signaling pathway_Homo sapiens_hsa040141.10969543
36Renin-angiotensin system_Homo sapiens_hsa046141.10780668
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10440594
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08613281
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08435602
40Melanogenesis_Homo sapiens_hsa049161.04276279
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03213581
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95562692
43Hematopoietic cell lineage_Homo sapiens_hsa046400.94549269
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.91223898
45Fatty acid biosynthesis_Homo sapiens_hsa000610.88837338
46Chronic myeloid leukemia_Homo sapiens_hsa052200.87963595
47Sphingolipid metabolism_Homo sapiens_hsa006000.86176960
48Other glycan degradation_Homo sapiens_hsa005110.85949219
49Platelet activation_Homo sapiens_hsa046110.84902162
50Viral myocarditis_Homo sapiens_hsa054160.84657249
51Dorso-ventral axis formation_Homo sapiens_hsa043200.84643483
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82399402
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82106316
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.81503191
55Endocytosis_Homo sapiens_hsa041440.79708407
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.78687093
57Notch signaling pathway_Homo sapiens_hsa043300.77667376
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77117943
59Glioma_Homo sapiens_hsa052140.76792544
60Pancreatic cancer_Homo sapiens_hsa052120.76427347
61ErbB signaling pathway_Homo sapiens_hsa040120.75727628
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.73965458
63Lysosome_Homo sapiens_hsa041420.73546485
64Phagosome_Homo sapiens_hsa041450.72991960
65p53 signaling pathway_Homo sapiens_hsa041150.72774580
66TNF signaling pathway_Homo sapiens_hsa046680.72708731
67Lysine degradation_Homo sapiens_hsa003100.72051413
68Toxoplasmosis_Homo sapiens_hsa051450.71702750
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71636359
70Renal cell carcinoma_Homo sapiens_hsa052110.71412389
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69621628
72Bladder cancer_Homo sapiens_hsa052190.67977545
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67024470
74cAMP signaling pathway_Homo sapiens_hsa040240.66873498
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63845439
76Thyroid hormone synthesis_Homo sapiens_hsa049180.62108993
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61317228
78HTLV-I infection_Homo sapiens_hsa051660.61085422
79Tight junction_Homo sapiens_hsa045300.60528330
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.60249092
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60096886
82MAPK signaling pathway_Homo sapiens_hsa040100.59860006
83Calcium signaling pathway_Homo sapiens_hsa040200.59838510
84Gap junction_Homo sapiens_hsa045400.59739520
85Nicotine addiction_Homo sapiens_hsa050330.59027763
86GnRH signaling pathway_Homo sapiens_hsa049120.58807503
87Phototransduction_Homo sapiens_hsa047440.58765693
88Serotonergic synapse_Homo sapiens_hsa047260.58681530
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.58226092
90Vibrio cholerae infection_Homo sapiens_hsa051100.57801619
91Morphine addiction_Homo sapiens_hsa050320.57232801
92Arachidonic acid metabolism_Homo sapiens_hsa005900.56424988
93FoxO signaling pathway_Homo sapiens_hsa040680.55750264
94Autoimmune thyroid disease_Homo sapiens_hsa053200.55746875
95Mineral absorption_Homo sapiens_hsa049780.54077051
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53940893
97Renin secretion_Homo sapiens_hsa049240.53554416
98Fanconi anemia pathway_Homo sapiens_hsa034600.52343613
99Endometrial cancer_Homo sapiens_hsa052130.51358817
100Shigellosis_Homo sapiens_hsa051310.51158650
101Taste transduction_Homo sapiens_hsa047420.50323787
102Salivary secretion_Homo sapiens_hsa049700.49402244
103Choline metabolism in cancer_Homo sapiens_hsa052310.49246706
104Prolactin signaling pathway_Homo sapiens_hsa049170.49221532
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48647520
106Prion diseases_Homo sapiens_hsa050200.48387266
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.48094952
108Colorectal cancer_Homo sapiens_hsa052100.47245724
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.47144978
110Rheumatoid arthritis_Homo sapiens_hsa053230.46396469
111Long-term depression_Homo sapiens_hsa047300.46038389
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.45877340
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.44269984
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43941700
115Complement and coagulation cascades_Homo sapiens_hsa046100.43431822
116Oxytocin signaling pathway_Homo sapiens_hsa049210.42448803
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41981314
118Cholinergic synapse_Homo sapiens_hsa047250.41812050
119Cocaine addiction_Homo sapiens_hsa050300.40934108
120Inositol phosphate metabolism_Homo sapiens_hsa005620.39682626
121Measles_Homo sapiens_hsa051620.39535471
122Osteoclast differentiation_Homo sapiens_hsa043800.39342009
123Galactose metabolism_Homo sapiens_hsa000520.39306290
124Estrogen signaling pathway_Homo sapiens_hsa049150.38985384
125Chemokine signaling pathway_Homo sapiens_hsa040620.38634085
126Glutamatergic synapse_Homo sapiens_hsa047240.37830588
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37002661
128Pertussis_Homo sapiens_hsa051330.36949665
129Hepatitis B_Homo sapiens_hsa051610.34928496
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33275569

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