ADAM15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.67571522
2Golgi transport vesicle coating (GO:0048200)5.51981628
3COPI coating of Golgi vesicle (GO:0048205)5.51981628
4apoptotic cell clearance (GO:0043277)4.21436094
5protein retention in ER lumen (GO:0006621)4.07682687
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.03888613
7modulation by symbiont of host defense response (GO:0052031)3.97406211
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97406211
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97406211
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.97406211
11modulation by symbiont of host immune response (GO:0052553)3.97406211
12positive regulation by symbiont of host defense response (GO:0052509)3.97406211
13activation of Rac GTPase activity (GO:0032863)3.80964960
14mannose metabolic process (GO:0006013)3.80302380
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.79540050
16regulation of water loss via skin (GO:0033561)3.67850216
17adherens junction assembly (GO:0034333)3.58568834
18focal adhesion assembly (GO:0048041)3.51282609
19cell-substrate adherens junction assembly (GO:0007045)3.51282609
20negative regulation of cell size (GO:0045792)3.50158876
21epithelial cell-cell adhesion (GO:0090136)3.49424067
22epithelial cell differentiation involved in prostate gland development (GO:0060742)3.47375122
23macrophage activation involved in immune response (GO:0002281)3.40475472
24protein localization to endosome (GO:0036010)3.38572506
25proline biosynthetic process (GO:0006561)3.36090409
26vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.32730389
27dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31122507
28positive regulation of Cdc42 GTPase activity (GO:0043089)3.30474585
29low-density lipoprotein particle clearance (GO:0034383)3.28207453
30apoptotic process involved in morphogenesis (GO:0060561)3.26833280
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.22154948
32stress fiber assembly (GO:0043149)3.22068806
33pinocytosis (GO:0006907)3.20920931
34surfactant homeostasis (GO:0043129)3.20329815
35regulation of interferon-beta biosynthetic process (GO:0045357)3.16187503
36protein maturation by protein folding (GO:0022417)3.14579938
37skin morphogenesis (GO:0043589)3.11956075
38pentose-phosphate shunt (GO:0006098)3.11950994
39establishment of skin barrier (GO:0061436)3.11618371
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09755870
41glucose catabolic process (GO:0006007)3.07487060
42leukocyte migration involved in inflammatory response (GO:0002523)3.04891438
43negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.03794348
44cell adhesion mediated by integrin (GO:0033627)3.03298239
45maternal placenta development (GO:0001893)3.01684387
46positive regulation of receptor recycling (GO:0001921)3.01304135
47positive regulation of keratinocyte differentiation (GO:0045618)2.96487800
48adhesion of symbiont to host cell (GO:0044650)2.95668960
49virion attachment to host cell (GO:0019062)2.95668960
50negative regulation of erythrocyte differentiation (GO:0045647)2.95094310
51regulation of macrophage chemotaxis (GO:0010758)2.94983632
52cortical actin cytoskeleton organization (GO:0030866)2.93649039
53retina vasculature morphogenesis in camera-type eye (GO:0061299)2.93203857
54branching involved in mammary gland duct morphogenesis (GO:0060444)2.90029725
55positive regulation of blood vessel endothelial cell migration (GO:0043536)2.89410981
56amyloid precursor protein catabolic process (GO:0042987)2.87429027
57regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86699940
58regulation of integrin activation (GO:0033623)2.86199776
59regulation of glucose import in response to insulin stimulus (GO:2001273)2.81728845
60adhesion of symbiont to host (GO:0044406)2.78779680
61plasma membrane repair (GO:0001778)2.77976134
62planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77611260
63basement membrane organization (GO:0071711)2.77464124
64microglial cell activation (GO:0001774)2.72212547
65atrioventricular valve morphogenesis (GO:0003181)2.71934882
66membrane protein ectodomain proteolysis (GO:0006509)2.71399923
67activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.71390329
68multicellular organismal water homeostasis (GO:0050891)2.70454745
69cortical cytoskeleton organization (GO:0030865)2.68080631
70regulation of cholesterol storage (GO:0010885)2.67592107
71positive regulation of epidermal cell differentiation (GO:0045606)2.67098295
72endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.65922448
73negative regulation of fatty acid transport (GO:2000192)2.63749877
74keratan sulfate catabolic process (GO:0042340)2.62970633
75semaphorin-plexin signaling pathway (GO:0071526)2.62849592
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61618431
77NADPH regeneration (GO:0006740)2.60786801
78endothelial cell chemotaxis (GO:0035767)2.59910818
79regulation of macrophage cytokine production (GO:0010935)2.59055068
80glucose 6-phosphate metabolic process (GO:0051156)2.57991980
81positive regulation of nuclease activity (GO:0032075)2.57757500
82positive regulation of macrophage cytokine production (GO:0060907)2.57264854
83cellular copper ion homeostasis (GO:0006878)2.55825446
84endothelium development (GO:0003158)2.55778396
85vascular endothelial growth factor signaling pathway (GO:0038084)2.55728179
86NADH metabolic process (GO:0006734)2.54497551
87negative regulation of granulocyte differentiation (GO:0030853)2.50810701
88regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50236812
89embryo implantation (GO:0007566)2.49854991
90hypotonic response (GO:0006971)2.48664947
91mitotic nuclear envelope reassembly (GO:0007084)2.47287264
92nuclear envelope reassembly (GO:0031468)2.47287264
93amyloid precursor protein metabolic process (GO:0042982)2.47232563
94response to host immune response (GO:0052572)2.45397297
95response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45397297
96neutrophil activation involved in immune response (GO:0002283)2.43877656
97positive regulation of epidermis development (GO:0045684)2.43615426
98response to laminar fluid shear stress (GO:0034616)2.43107067
99substrate-dependent cell migration (GO:0006929)2.43081604
100negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42859152
101regulation of cholesterol biosynthetic process (GO:0045540)2.42447794
102negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.42382352
103regulation of endothelial cell chemotaxis (GO:2001026)2.42356775
104cellular extravasation (GO:0045123)2.41836428
105negative regulation of viral release from host cell (GO:1902187)2.41312121
106endoplasmic reticulum unfolded protein response (GO:0030968)2.40269695
107GDP-mannose metabolic process (GO:0019673)2.40136478
108peptidyl-proline hydroxylation (GO:0019511)2.38031459
109wound healing, spreading of cells (GO:0044319)2.37982779
110hyaluronan catabolic process (GO:0030214)2.37895065
111regulation of synapse structural plasticity (GO:0051823)2.37746049
112membrane raft organization (GO:0031579)2.35394927
113urea cycle (GO:0000050)2.35231764
114vesicle coating (GO:0006901)2.34757718
115angiogenesis involved in wound healing (GO:0060055)2.34571760
116modulation by virus of host morphology or physiology (GO:0019048)2.34008317
117regulation of translational fidelity (GO:0006450)2.33059525
118insulin-like growth factor receptor signaling pathway (GO:0048009)2.32715228
119regulation of p38MAPK cascade (GO:1900744)2.31922127
120positive regulation of p38MAPK cascade (GO:1900745)2.31728597
121neuron projection extension involved in neuron projection guidance (GO:1902284)2.30696194
122axon extension involved in axon guidance (GO:0048846)2.30696194
123ER-nucleus signaling pathway (GO:0006984)2.30302196
124endodermal cell differentiation (GO:0035987)2.30290898
125response to host (GO:0075136)2.30200326
126response to host defenses (GO:0052200)2.30200326
127response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.30200326
128Rho protein signal transduction (GO:0007266)2.29576235
129UV protection (GO:0009650)2.29149434
130regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28964500
131regulation of mononuclear cell migration (GO:0071675)2.28830989
132response to fluid shear stress (GO:0034405)2.28346288
133macrophage activation (GO:0042116)2.28267573
134regulation of early endosome to late endosome transport (GO:2000641)2.26458636
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24455724
136endothelial cell morphogenesis (GO:0001886)2.24317796
137sodium ion export (GO:0071436)2.24010712
138response to peptidoglycan (GO:0032494)2.23923937
139barbed-end actin filament capping (GO:0051016)2.23177394
140glomerular filtration (GO:0003094)2.22901101
141blood vessel maturation (GO:0001955)2.22877663
142renal filtration (GO:0097205)2.22660721
143negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.22106393
144positive regulation of Rap GTPase activity (GO:0032854)2.21483853
145regulation of ARF GTPase activity (GO:0032312)2.20262707
146positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.20073347
147negative regulation of interleukin-8 production (GO:0032717)2.18023421
148wound healing, spreading of epidermal cells (GO:0035313)2.16669029
149endocytic recycling (GO:0032456)2.15554082
150cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.14858823
151hemidesmosome assembly (GO:0031581)2.14544557
152response to nerve growth factor (GO:1990089)2.14487709
153cellular response to nerve growth factor stimulus (GO:1990090)2.14487709
154L-amino acid import (GO:0043092)2.14464223
155negative regulation of smooth muscle cell migration (GO:0014912)2.13681576
156phagocytosis (GO:0006909)2.13506883
157cell-substrate junction assembly (GO:0007044)2.12620147
158detection of molecule of bacterial origin (GO:0032490)2.12492904
159protein targeting to plasma membrane (GO:0072661)2.12067576
160germinal center formation (GO:0002467)2.11865963
161protein heterotrimerization (GO:0070208)2.11313339
162clathrin coat assembly (GO:0048268)2.06561040
163regulation of apoptotic cell clearance (GO:2000425)2.05863845
164positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.05764941
165negative regulation of interleukin-6 production (GO:0032715)2.05293002
166response to muramyl dipeptide (GO:0032495)2.04402674
167myeloid cell activation involved in immune response (GO:0002275)2.03219325
168regulation of membrane protein ectodomain proteolysis (GO:0051043)2.02271887
169negative regulation of cell killing (GO:0031342)2.01861677
170negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.01861677
171adenosine receptor signaling pathway (GO:0001973)2.01462039
172peptidyl-tyrosine autophosphorylation (GO:0038083)1.99811448
173positive regulation of fibroblast migration (GO:0010763)1.99574479
174regulation of Rap GTPase activity (GO:0032317)1.97570489
175regulation of leukocyte degranulation (GO:0043300)1.97290182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.02956695
2ZNF263_19887448_ChIP-Seq_K562_Human3.02637451
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.85503426
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.72819986
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58274479
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.37265745
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25688563
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23736234
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21225202
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10597855
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10249940
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03147393
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.01739073
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97577908
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96441017
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96423716
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95501247
18* ELK3_25401928_ChIP-Seq_HUVEC_Human1.91252066
19GATA2_21666600_ChIP-Seq_HMVEC_Human1.88146404
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84363896
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.83940444
22* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.79549060
23MYC_22102868_ChIP-Seq_BL_Human1.78798594
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77260446
25* LXR_22292898_ChIP-Seq_THP-1_Human1.74193966
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73187441
27SPI1_23127762_ChIP-Seq_K562_Human1.69117065
28DROSHA_22980978_ChIP-Seq_HELA_Human1.67062229
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66647987
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64026889
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61892504
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61845145
33CLOCK_20551151_ChIP-Seq_293T_Human1.60650380
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59744345
35ATF3_27146783_Chip-Seq_COLON_Human1.58249647
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56888592
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56415810
38* KDM2B_26808549_Chip-Seq_K562_Human1.53867843
39* KDM2B_26808549_Chip-Seq_DND41_Human1.52132731
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51517478
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50245997
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48619243
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47959315
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47156256
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.45450787
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44931416
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44335063
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44031290
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43731996
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43731996
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43585079
52P68_20966046_ChIP-Seq_HELA_Human1.43199288
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41113991
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40159063
55* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39475750
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38583800
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38350118
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37656474
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37612217
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33758163
61TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33382021
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32642858
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.32545600
64SMC4_20622854_ChIP-Seq_HELA_Human1.32518029
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32486011
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32164262
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32043393
68RACK7_27058665_Chip-Seq_MCF-7_Human1.31263898
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.30483303
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.30371403
71* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28688482
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.28404356
73* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28054849
74* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26161483
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25953715
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25847809
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25847809
78CREB1_26743006_Chip-Seq_LNCaP_Human1.25802906
79* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25642290
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24713328
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24179493
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23902239
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23885616
84VDR_24787735_ChIP-Seq_THP-1_Human1.23606108
85* UBF1/2_26484160_Chip-Seq_HMECs_Human1.23105308
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22563749
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21571482
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21297638
89CJUN_26792858_Chip-Seq_BT549_Human1.21110879
90GATA1_19941826_ChIP-Seq_K562_Human1.19406640
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19291489
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17382556
93* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16884027
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16451643
95* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14993914
96PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14870622
97VDR_21846776_ChIP-Seq_THP-1_Human1.14455820
98VDR_24763502_ChIP-Seq_THP-1_Human1.14364027
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.13801817
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.13801817
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.13563882
102* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13172968
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12459065
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12267080
105PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10681456
106* TP53_22127205_ChIP-Seq_IMR90_Human1.10480952
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10303776
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.10141627
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09935514
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09468841
111TCF7_22412390_ChIP-Seq_EML_Mouse1.08399001
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07788320
113NCOR1_26117541_ChIP-Seq_K562_Human1.07423504
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06638638
115RXR_22158963_ChIP-Seq_LIVER_Mouse1.06142216
116JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06018744
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05652728
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05550516
119ERG_21242973_ChIP-ChIP_JURKAT_Human1.05505224
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05217441
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04091166
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.03963343
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03579548
124TP53_16413492_ChIP-PET_HCT116_Human1.03522593
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03484644
126EGR1_19374776_ChIP-ChIP_THP-1_Human1.03047918
127SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02917413
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.01691863
129SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01516401
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01257828
131TP63_22573176_ChIP-Seq_HFKS_Human1.00507355
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00396994
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00330057
134NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00330057
135* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00311956
136BCOR_27268052_Chip-Seq_Bcells_Human1.00294662
137ELF1_20517297_ChIP-Seq_JURKAT_Human1.00013564
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99847750
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99736743
140SOX2_20726797_ChIP-Seq_SW620_Human0.99413906
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98713733
142* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98444074
143GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98339681
144* MAF_26560356_Chip-Seq_TH1_Human0.97807046
145SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97743234
146* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97359145
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96830179
148JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96644530
149SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96181385
150EED_16625203_ChIP-ChIP_MESCs_Mouse0.96076583
151AHR_22903824_ChIP-Seq_MCF-7_Human0.95126086
152E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94636836
153RNF2_27304074_Chip-Seq_ESCs_Mouse0.94386605
154JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94292792
155EZH2_27294783_Chip-Seq_ESCs_Mouse0.94240882
156* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94033945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.60451722
2MP0008438_abnormal_cutaneous_collagen4.50470198
3MP0005058_abnormal_lysosome_morphology3.84100967
4MP0003303_peritoneal_inflammation3.21432136
5MP0002796_impaired_skin_barrier3.11886039
6MP0002877_abnormal_melanocyte_morpholog2.76211759
7MP0003705_abnormal_hypodermis_morpholog2.73722506
8MP0001958_emphysema2.62833951
9MP0005451_abnormal_body_composition2.61875314
10MP0003172_abnormal_lysosome_physiology2.49543994
11MP0005167_abnormal_blood-brain_barrier2.48237639
12MP0004272_abnormal_basement_membrane2.47071233
13MP0003279_aneurysm2.36758526
14MP0003453_abnormal_keratinocyte_physiol2.36663942
15MP0005275_abnormal_skin_tensile2.34114399
16MP0003566_abnormal_cell_adhesion2.28716699
17MP0005409_darkened_coat_color2.27667392
18MP0005501_abnormal_skin_physiology2.22218461
19MP0003690_abnormal_glial_cell2.16784814
20MP0003300_gastrointestinal_ulcer2.06076216
21MP0003075_altered_response_to2.01868425
22MP0000579_abnormal_nail_morphology1.97748866
23MP0004858_abnormal_nervous_system1.97297153
24MP0010368_abnormal_lymphatic_system1.96446177
25MP0000751_myopathy1.94858908
26MP0008260_abnormal_autophagy1.94436950
27MP0004510_myositis1.89804745
28MP0000343_altered_response_to1.82730039
29MP0005076_abnormal_cell_differentiation1.79269486
30MP0004859_abnormal_synaptic_plasticity1.78382620
31MP0005623_abnormal_meninges_morphology1.77983506
32MP0000604_amyloidosis1.73703052
33MP0000467_abnormal_esophagus_morphology1.73113288
34MP0001216_abnormal_epidermal_layer1.69615708
35MP0003724_increased_susceptibility_to1.68721788
36MP0001533_abnormal_skeleton_physiology1.68615996
37MP0004130_abnormal_muscle_cell1.67824372
38MP0003045_fibrosis1.65451486
39MP0003191_abnormal_cellular_cholesterol1.63587940
40MP0004782_abnormal_surfactant_physiolog1.61417351
41MP0000537_abnormal_urethra_morphology1.60354965
42MP0003091_abnormal_cell_migration1.60216857
43MP0003436_decreased_susceptibility_to1.60163887
44MP0000678_abnormal_parathyroid_gland1.60108863
45MP0002098_abnormal_vibrissa_morphology1.59793383
46MP0004264_abnormal_extraembryonic_tissu1.57432357
47MP0010352_gastrointestinal_tract_polyps1.56985117
48MP0004233_abnormal_muscle_weight1.54799848
49MP0003329_amyloid_beta_deposits1.53412783
50MP0004185_abnormal_adipocyte_glucose1.52788417
51MP0000858_altered_metastatic_potential1.51802702
52MP0003828_pulmonary_edema1.51368271
53MP0001851_eye_inflammation1.51349376
54MP0001879_abnormal_lymphatic_vessel1.50111406
55MP0010030_abnormal_orbit_morphology1.49594350
56MP0004084_abnormal_cardiac_muscle1.47156705
57MP0002419_abnormal_innate_immunity1.44508644
58MP0005670_abnormal_white_adipose1.41606661
59MP0006082_CNS_inflammation1.40619849
60MP0003183_abnormal_peptide_metabolism1.39008700
61MP0009278_abnormal_bone_marrow1.38525535
62MP0000920_abnormal_myelination1.36060887
63MP0009840_abnormal_foam_cell1.33883347
64MP0000750_abnormal_muscle_regeneration1.30781414
65MP0000762_abnormal_tongue_morphology1.30674049
66MP0002998_abnormal_bone_remodeling1.29691947
67MP0000013_abnormal_adipose_tissue1.27026147
68MP0002295_abnormal_pulmonary_circulatio1.26626058
69MP0000767_abnormal_smooth_muscle1.26421113
70MP0010771_integument_phenotype1.19161452
71MP0000566_synostosis1.16762087
72MP0005164_abnormal_response_to1.15222156
73MP0000377_abnormal_hair_follicle1.14343144
74MP0000249_abnormal_blood_vessel1.13724249
75MP0003634_abnormal_glial_cell1.13372147
76MP0010678_abnormal_skin_adnexa1.13028238
77MP0005165_increased_susceptibility_to1.12995462
78MP0009931_abnormal_skin_appearance1.12249944
79MP0004381_abnormal_hair_follicle1.12049365
80MP0005083_abnormal_biliary_tract1.06636139
81MP0005666_abnormal_adipose_tissue1.05593543
82MP0005375_adipose_tissue_phenotype1.05061726
83MP0009053_abnormal_anal_canal1.03662240
84MP0005464_abnormal_platelet_physiology1.03592033
85MP0002896_abnormal_bone_mineralization1.03336726
86MP0005023_abnormal_wound_healing1.02982049
87* MP0003448_altered_tumor_morphology1.00872339
88MP0005166_decreased_susceptibility_to0.99507061
89MP0005390_skeleton_phenotype0.98252026
90MP0003941_abnormal_skin_development0.97977690
91MP0000569_abnormal_digit_pigmentation0.96886537
92MP0004036_abnormal_muscle_relaxation0.96873279
93MP0004947_skin_inflammation0.93220938
94MP0000627_abnormal_mammary_gland0.92640463
95MP0000733_abnormal_muscle_development0.92298908
96MP0006138_congestive_heart_failure0.92148031
97MP0004087_abnormal_muscle_fiber0.91167771
98MP0000747_muscle_weakness0.91089645
99MP0005000_abnormal_immune_tolerance0.90566832
100MP0001348_abnormal_lacrimal_gland0.90362524
101MP0000465_gastrointestinal_hemorrhage0.89499980
102MP0002090_abnormal_vision0.89341017
103MP0002148_abnormal_hypersensitivity_rea0.89318711
104MP0009780_abnormal_chondrocyte_physiolo0.88702485
105MP0002933_joint_inflammation0.88562374
106MP0005595_abnormal_vascular_smooth0.88407237
107MP0004484_altered_response_of0.88233353
108MP0005257_abnormal_intraocular_pressure0.87639847
109MP0004883_abnormal_blood_vessel0.86886073
110MP0001544_abnormal_cardiovascular_syste0.85332120
111MP0005385_cardiovascular_system_phenoty0.85332120
112MP0003633_abnormal_nervous_system0.84815376
113MP0002909_abnormal_adrenal_gland0.83850464
114MP0000003_abnormal_adipose_tissue0.83696423
115MP0005360_urolithiasis0.83293494
116MP0002837_dystrophic_cardiac_calcinosis0.81658729
117MP0005503_abnormal_tendon_morphology0.81249559
118MP0005388_respiratory_system_phenotype0.81173252
119MP0002133_abnormal_respiratory_system0.81173252
120MP0005621_abnormal_cell_physiology0.80927379
121MP0008775_abnormal_heart_ventricle0.79907758
122MP0005025_abnormal_response_to0.79184196
123MP0002972_abnormal_cardiac_muscle0.79106284
124MP0000749_muscle_degeneration0.76168212
125MP0008004_abnormal_stomach_pH0.76148515
126MP0001243_abnormal_dermal_layer0.76028855
127MP0010630_abnormal_cardiac_muscle0.75252898
128* MP0001614_abnormal_blood_vessel0.74719598
129MP0002249_abnormal_larynx_morphology0.73634494
130MP0001881_abnormal_mammary_gland0.72890254
131MP0001790_abnormal_immune_system0.72626448
132MP0005387_immune_system_phenotype0.72626448
133MP0001661_extended_life_span0.72483192
134MP0005330_cardiomyopathy0.71189457
135MP0002064_seizures0.70623859
136MP0001849_ear_inflammation0.70399636
137MP0001299_abnormal_eye_distance/0.70205664
138MP0006054_spinal_hemorrhage0.69083639
139MP0002089_abnormal_postnatal_growth/wei0.68926287
140MP0002168_other_aberrant_phenotype0.68324715
141MP0008961_abnormal_basal_metabolism0.68157829
142MP0002060_abnormal_skin_morphology0.67576623
143MP0002128_abnormal_blood_circulation0.66843478
144MP0000759_abnormal_skeletal_muscle0.66467254
145MP0001873_stomach_inflammation0.65919200
146MP0000681_abnormal_thyroid_gland0.64807169
147MP0001915_intracranial_hemorrhage0.63190584
148MP0002086_abnormal_extraembryonic_tissu0.63088071
149MP0000490_abnormal_crypts_of0.61126212
150MP0005508_abnormal_skeleton_morphology0.58524156
151MP0002970_abnormal_white_adipose0.57713104

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)4.58903223
2Increased cerebral lipofuscin (HP:0011813)4.52001564
3Systemic lupus erythematosus (HP:0002725)4.48753541
4Cerebral aneurysm (HP:0004944)4.40178631
5Abnormality of glycolipid metabolism (HP:0010969)4.21098457
6Abnormality of liposaccharide metabolism (HP:0010968)4.21098457
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.21098457
8J-shaped sella turcica (HP:0002680)3.73917659
9Vacuolated lymphocytes (HP:0001922)3.67947847
10Premature rupture of membranes (HP:0001788)3.67937835
11Urinary glycosaminoglycan excretion (HP:0003541)3.67494261
12Mucopolysacchariduria (HP:0008155)3.67494261
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.66696741
14Abnormality of polysaccharide metabolism (HP:0011012)3.48974312
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.48974312
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.48974312
17Shallow orbits (HP:0000586)3.37147688
18Distal lower limb muscle weakness (HP:0009053)3.36669577
19Protrusio acetabuli (HP:0003179)3.22604869
20Axonal loss (HP:0003447)3.15826123
21Distal lower limb amyotrophy (HP:0008944)3.12241596
22Broad face (HP:0000283)3.08462940
23Short nail (HP:0001799)3.07334753
24Broad metatarsal (HP:0001783)2.96916612
25Arterial tortuosity (HP:0005116)2.93791062
26Abnormality of the lumbar spine (HP:0100712)2.90941214
27Right ventricular cardiomyopathy (HP:0011663)2.88843419
28Loss of speech (HP:0002371)2.88270735
29Hyperacusis (HP:0010780)2.86832333
30Glomerulonephritis (HP:0000099)2.86725532
31Vascular tortuosity (HP:0004948)2.86508833
32Mutism (HP:0002300)2.84985508
33Neurofibrillary tangles (HP:0002185)2.84328941
34Supranuclear gaze palsy (HP:0000605)2.79499206
35Milia (HP:0001056)2.77198588
36Abnormality of the distal phalanges of the toes (HP:0010182)2.76668075
37Asymmetric septal hypertrophy (HP:0001670)2.73932101
38Recurrent abscess formation (HP:0002722)2.69960012
39Aortic dissection (HP:0002647)2.69391945
40Pili torti (HP:0003777)2.64013021
41Abnormality of nail color (HP:0100643)2.63181394
42Thin bony cortex (HP:0002753)2.59495459
43Eczematoid dermatitis (HP:0000976)2.59281246
44Thoracic kyphosis (HP:0002942)2.58527965
45Upper limb amyotrophy (HP:0009129)2.55674583
46Distal upper limb amyotrophy (HP:0007149)2.55674583
47Disinhibition (HP:0000734)2.55511267
48Cerebral inclusion bodies (HP:0100314)2.52229994
49Hematochezia (HP:0002573)2.51482848
50Cervical subluxation (HP:0003308)2.50177920
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49812093
52Neuronal loss in central nervous system (HP:0002529)2.48021035
53Peritonitis (HP:0002586)2.46675127
54Trismus (HP:0000211)2.42797622
55Aortic aneurysm (HP:0004942)2.41114844
56Fragile nails (HP:0001808)2.40828176
57Abnormality of macrophages (HP:0004311)2.37352686
58Nail dystrophy (HP:0008404)2.36638230
59Onycholysis (HP:0001806)2.34991997
60Apathy (HP:0000741)2.31037055
61Advanced eruption of teeth (HP:0006288)2.30608651
62Increased connective tissue (HP:0009025)2.29972086
63Natal tooth (HP:0000695)2.28290411
64Hand muscle atrophy (HP:0009130)2.27505272
65Deformed sella turcica (HP:0002681)2.27151210
66Ankyloglossia (HP:0010296)2.23375500
67Increased variability in muscle fiber diameter (HP:0003557)2.22708100
68Spondylolisthesis (HP:0003302)2.22518914
69Rapidly progressive (HP:0003678)2.20879222
70Ulnar bowing (HP:0003031)2.20657443
71Abnormal hair laboratory examination (HP:0003328)2.19146644
72Plantar hyperkeratosis (HP:0007556)2.18916675
73Diminished motivation (HP:0000745)2.18379879
74Abnormality of the Achilles tendon (HP:0005109)2.17290706
75Ovoid vertebral bodies (HP:0003300)2.14490208
76Muscle fiber splitting (HP:0003555)2.14243851
77Bladder diverticulum (HP:0000015)2.13307907
78Alopecia of scalp (HP:0002293)2.13116154
79Centrally nucleated skeletal muscle fibers (HP:0003687)2.13048085
80Abnormality of complement system (HP:0005339)2.12449467
81Atrophic scars (HP:0001075)2.10432394
82Hemorrhage of the eye (HP:0011885)2.08866905
83Wrist flexion contracture (HP:0001239)2.07125559
84Mildly elevated creatine phosphokinase (HP:0008180)2.06722930
85Ankle contracture (HP:0006466)2.06467880
86Abnormality of oral frenula (HP:0000190)2.06314349
87Nephritis (HP:0000123)2.05738590
88Selective tooth agenesis (HP:0001592)2.04695762
89Ridged nail (HP:0001807)2.02045691
90Recurrent bacterial skin infections (HP:0005406)2.01729137
91Blue sclerae (HP:0000592)2.00741417
92Joint stiffness (HP:0001387)1.99884990
93Acanthosis nigricans (HP:0000956)1.99730097
94Abnormality of skeletal muscle fiber size (HP:0012084)1.99256399
95Dilatation of the ascending aorta (HP:0005111)1.99203613
96Mitral valve prolapse (HP:0001634)1.98706264
97Elbow flexion contracture (HP:0002987)1.98104437
98Neonatal death (HP:0003811)1.97514714
99Spinal cord compression (HP:0002176)1.97478115
100Fragile skin (HP:0001030)1.97231854
101Hypoplasia of the odontoid process (HP:0003311)1.96488833
102Difficulty running (HP:0009046)1.96017054
103Stridor (HP:0010307)1.95026618
104Complement deficiency (HP:0004431)1.94836308
105Nuclear cataract (HP:0100018)1.94689879
106Lower limb amyotrophy (HP:0007210)1.93988823
107Vertebral compression fractures (HP:0002953)1.93464028
108Broad ribs (HP:0000885)1.93162823
109Aneurysm (HP:0002617)1.92366075
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.90747659
111Osteolytic defects of the hand bones (HP:0009699)1.90747659
112Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88709614
113Hyporeflexia of lower limbs (HP:0002600)1.87388206
114Flat acetabular roof (HP:0003180)1.86962441
115Abnormality of the odontoid process (HP:0003310)1.86935334
116Striae distensae (HP:0001065)1.85704771
117Spinal rigidity (HP:0003306)1.85305578
118Disproportionate tall stature (HP:0001519)1.85100172
119Obstructive sleep apnea (HP:0002870)1.84287487
120Polygenic inheritance (HP:0010982)1.83562251
121Hypotrichosis (HP:0001006)1.83476961
122Abnormal blistering of the skin (HP:0008066)1.83211012
123Abnormality of the sella turcica (HP:0002679)1.82334771
124Back pain (HP:0003418)1.82094003
125Coxa vara (HP:0002812)1.81405313
126Generalized amyotrophy (HP:0003700)1.81293940
127Hyperparathyroidism (HP:0000843)1.81228450
128Beaking of vertebral bodies (HP:0004568)1.80729217
129Thick nail (HP:0001805)1.79620010
130Papilledema (HP:0001085)1.77981189
131Bulbar palsy (HP:0001283)1.77649650
132Achilles tendon contracture (HP:0001771)1.77412716
133Deep venous thrombosis (HP:0002625)1.77190622
134Abnormality of the nasal mucosa (HP:0000433)1.76833709
135Sparse lateral eyebrow (HP:0005338)1.76574732
136Bronchomalacia (HP:0002780)1.76291361
137Recurrent gram-negative bacterial infections (HP:0005420)1.76090741
138Reduced subcutaneous adipose tissue (HP:0003758)1.75923428
139Interstitial pulmonary disease (HP:0006530)1.75706558
140Mitral regurgitation (HP:0001653)1.75578809
141Pterygium (HP:0001059)1.73750324
142Spontaneous hematomas (HP:0007420)1.73323114
143Abnormality of the thoracic spine (HP:0100711)1.72733546
144Scapular winging (HP:0003691)1.72014822
145Soft skin (HP:0000977)1.69842563
146Esophageal varix (HP:0002040)1.68969173
147Difficulty climbing stairs (HP:0003551)1.68721974
148Bone pain (HP:0002653)1.67940964
149Wormian bones (HP:0002645)1.67883240
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.67805168
151Pathologic fracture (HP:0002756)1.65834719
152Palmoplantar hyperkeratosis (HP:0000972)1.65303151
153Diplopia (HP:0000651)1.64979498
154Abnormality of binocular vision (HP:0011514)1.64979498
155Hemiplegia (HP:0002301)1.64655703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.21372280
2TRIB33.61747227
3SIK13.00286530
4TGFBR22.97360583
5ERN12.88530201
6IRAK32.84992520
7TTN2.82914717
8TIE12.65240589
9SMG12.62264474
10RIPK12.51074175
11EPHB12.50192154
12CAMK1D2.33753795
13NME22.32544035
14PKN22.23507551
15EEF2K2.22013114
16CAMK1G2.16713926
17TESK12.12491643
18PRPF4B2.08129946
19BLK1.77338669
20NTRK11.75529120
21MST1R1.71593151
22MAP3K91.68887957
23FES1.65990519
24RIPK41.63999870
25PTK2B1.59568652
26KSR21.55369061
27KDR1.51456477
28LMTK21.50028526
29BMX1.46582085
30DMPK1.44819737
31CAMKK11.43002591
32MAPKAPK31.42143235
33CAMKK21.41796446
34PAK41.31549354
35CDK121.31467863
36DAPK21.31461158
37KIT1.30455245
38FGR1.29771281
39PAK61.26793450
40DDR21.25382263
41MAP3K61.24893799
42MET1.22603825
43EPHB21.20806727
44PDGFRA1.19935447
45PTK61.17945602
46TESK21.17551688
47TBK11.14783743
48SIK21.11867719
49SCYL21.10874678
50TAOK21.03580781
51PRKCH1.03540300
52PRKD20.98270833
53DAPK30.98051935
54FER0.96870755
55LRRK20.96768298
56RET0.95746684
57PDPK10.95532471
58FGFR40.95263460
59PTK20.94622337
60CSK0.94619189
61MTOR0.93108701
62MOS0.92315458
63PAK20.91722870
64RPS6KB20.90962851
65PHKG20.90689640
66PHKG10.90689640
67CSF1R0.87928074
68MAP3K130.87852509
69PRKD10.86617947
70MAP2K30.82479652
71MAP3K10.78927697
72PRKD30.78718310
73ZAP700.78513360
74JAK10.77025980
75ARAF0.75973481
76TYK20.75081287
77* HCK0.74561241
78TRPM70.73651062
79CDC42BPA0.73635142
80MAP3K110.70624776
81LIMK10.68820862
82MATK0.68770189
83FYN0.65866962
84MAP3K20.64544068
85IRAK20.62868008
86PIM20.62453983
87ICK0.62240614
88ROCK20.61277034
89MAP3K80.61156992
90MAP3K30.61008538
91PRKG20.59800164
92CDK50.57596856
93MAP2K10.56824940
94PDGFRB0.56675933
95MAPK120.55705732
96LATS20.55456001
97CAMK10.55052893
98STK380.54916334
99PDK10.54555786
100BRAF0.53913302
101* SRC0.52748069
102FLT30.52614971
103NTRK30.52536359
104WNK10.51701085
105GRK70.51392227
106CDK70.51171947
107JAK20.50953590
108ILK0.50609898
109EGFR0.49404275
110RPS6KC10.49390578
111RPS6KL10.49390578
112RPS6KA20.49368362
113MAP4K10.49266678
114PAK30.49123011
115ABL20.48789123
116TAOK10.47187702
117SIK30.45790678
118GSK3A0.44615290
119CLK10.44029155
120CDK60.43634337
121EPHA40.43552583
122MAP2K20.43317699
123MYLK0.42364039
124STK390.41990598
125CAMK40.41856584
126CAMK2D0.41649984
127MARK20.40668940
128ROCK10.40428985
129MAPKAPK20.39948587
130ALK0.39444564
131STK100.39055165
132MAP3K140.37822674
133PRKCI0.36487723
134MAPK110.36442357
135HIPK20.35334130
136IRAK40.32881998
137ERBB40.31202502
138MAP2K60.31137901
139RPS6KA60.28633340
140JAK30.26512211
141CDK80.25809994
142AKT20.25509289
143CAMK2G0.24405789

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.66495591
2Lysosome_Homo sapiens_hsa041422.56023531
3Other glycan degradation_Homo sapiens_hsa005112.53042895
4Staphylococcus aureus infection_Homo sapiens_hsa051502.20039652
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01874376
6Pentose phosphate pathway_Homo sapiens_hsa000301.97143627
7Fructose and mannose metabolism_Homo sapiens_hsa000511.93066689
8Notch signaling pathway_Homo sapiens_hsa043301.85888369
9Central carbon metabolism in cancer_Homo sapiens_hsa052301.80598830
10Galactose metabolism_Homo sapiens_hsa000521.63347271
11Pertussis_Homo sapiens_hsa051331.59132379
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.57848352
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56506164
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.55116004
15Malaria_Homo sapiens_hsa051441.53078034
16ECM-receptor interaction_Homo sapiens_hsa045121.50721244
17Osteoclast differentiation_Homo sapiens_hsa043801.47207386
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45552984
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44300465
20Leishmaniasis_Homo sapiens_hsa051401.43409578
21Focal adhesion_Homo sapiens_hsa045101.42714421
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42308431
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41539254
24Phagosome_Homo sapiens_hsa041451.40226759
25Amoebiasis_Homo sapiens_hsa051461.38235546
26Biosynthesis of amino acids_Homo sapiens_hsa012301.37944524
27Thyroid cancer_Homo sapiens_hsa052161.37281120
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35188480
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33488976
30Dilated cardiomyopathy_Homo sapiens_hsa054141.32349217
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28941539
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27779874
33Non-small cell lung cancer_Homo sapiens_hsa052231.27442708
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.26341273
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26032900
36Sulfur relay system_Homo sapiens_hsa041221.25081832
37Phenylalanine metabolism_Homo sapiens_hsa003601.24269771
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23660362
39Tuberculosis_Homo sapiens_hsa051521.20495955
40Salmonella infection_Homo sapiens_hsa051321.20269513
41Endometrial cancer_Homo sapiens_hsa052131.14909615
42Endocytosis_Homo sapiens_hsa041441.14011867
43Proteoglycans in cancer_Homo sapiens_hsa052051.13948581
44Platelet activation_Homo sapiens_hsa046111.13806409
45Insulin signaling pathway_Homo sapiens_hsa049101.12671979
46Synaptic vesicle cycle_Homo sapiens_hsa047211.11218950
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08756888
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08070614
49Renal cell carcinoma_Homo sapiens_hsa052111.07842503
50VEGF signaling pathway_Homo sapiens_hsa043701.05111323
51Prion diseases_Homo sapiens_hsa050201.02888769
52Arginine biosynthesis_Homo sapiens_hsa002201.01879426
53Rheumatoid arthritis_Homo sapiens_hsa053231.01236125
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.00424876
55Toxoplasmosis_Homo sapiens_hsa051450.99681626
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99510032
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98699611
58N-Glycan biosynthesis_Homo sapiens_hsa005100.98276107
59Renin secretion_Homo sapiens_hsa049240.98182077
60Gastric acid secretion_Homo sapiens_hsa049710.97968918
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97713995
62ErbB signaling pathway_Homo sapiens_hsa040120.97347828
63AMPK signaling pathway_Homo sapiens_hsa041520.95443452
64Salivary secretion_Homo sapiens_hsa049700.95269007
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.95142034
66Hepatitis C_Homo sapiens_hsa051600.94901852
67Shigellosis_Homo sapiens_hsa051310.94886856
68Rap1 signaling pathway_Homo sapiens_hsa040150.94805311
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94181645
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94004621
71Glioma_Homo sapiens_hsa052140.93566047
72mTOR signaling pathway_Homo sapiens_hsa041500.91911152
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91781366
74Insulin resistance_Homo sapiens_hsa049310.89979624
75Carbon metabolism_Homo sapiens_hsa012000.89338581
76Chemokine signaling pathway_Homo sapiens_hsa040620.89321241
77Collecting duct acid secretion_Homo sapiens_hsa049660.88907763
78Oxytocin signaling pathway_Homo sapiens_hsa049210.88025478
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87437410
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86944387
81B cell receptor signaling pathway_Homo sapiens_hsa046620.86688105
82Estrogen signaling pathway_Homo sapiens_hsa049150.85697881
83Chronic myeloid leukemia_Homo sapiens_hsa052200.85676401
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.84545752
85Dorso-ventral axis formation_Homo sapiens_hsa043200.84128759
86Axon guidance_Homo sapiens_hsa043600.81833684
87GnRH signaling pathway_Homo sapiens_hsa049120.81047129
88Apoptosis_Homo sapiens_hsa042100.81030987
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80408521
90HIF-1 signaling pathway_Homo sapiens_hsa040660.76537838
91Vibrio cholerae infection_Homo sapiens_hsa051100.75975239
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75417930
93Pancreatic cancer_Homo sapiens_hsa052120.74525135
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72944219
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.72582103
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71836860
97Circadian entrainment_Homo sapiens_hsa047130.70583741
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.70079505
99MicroRNAs in cancer_Homo sapiens_hsa052060.69757270
100Gap junction_Homo sapiens_hsa045400.69660251
101Cholinergic synapse_Homo sapiens_hsa047250.69006226
102Adherens junction_Homo sapiens_hsa045200.68840976
103Olfactory transduction_Homo sapiens_hsa047400.68750422
104Inositol phosphate metabolism_Homo sapiens_hsa005620.68734603
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68635781
106Sphingolipid metabolism_Homo sapiens_hsa006000.68023074
107Type II diabetes mellitus_Homo sapiens_hsa049300.67696965
108TNF signaling pathway_Homo sapiens_hsa046680.66937965
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66640545
110Long-term depression_Homo sapiens_hsa047300.66030616
111Morphine addiction_Homo sapiens_hsa050320.65812591
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65452049
113cAMP signaling pathway_Homo sapiens_hsa040240.65105313
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64817334
115Ras signaling pathway_Homo sapiens_hsa040140.62863468
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62556156
117Viral myocarditis_Homo sapiens_hsa054160.62036058
118Bladder cancer_Homo sapiens_hsa052190.61676039
119Choline metabolism in cancer_Homo sapiens_hsa052310.60613667
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60284956
121Long-term potentiation_Homo sapiens_hsa047200.60067799
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60021195
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58787627
124Prolactin signaling pathway_Homo sapiens_hsa049170.58606513
125Prostate cancer_Homo sapiens_hsa052150.58191414
126Glutamatergic synapse_Homo sapiens_hsa047240.57322307
127MAPK signaling pathway_Homo sapiens_hsa040100.56825372
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56339288
129Calcium signaling pathway_Homo sapiens_hsa040200.54667474
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54636678
131Hepatitis B_Homo sapiens_hsa051610.54496958
132Pathways in cancer_Homo sapiens_hsa052000.54267164
133Protein digestion and absorption_Homo sapiens_hsa049740.54031253
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53853115
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52694002
136Small cell lung cancer_Homo sapiens_hsa052220.51960918
137GABAergic synapse_Homo sapiens_hsa047270.51548880
138Acute myeloid leukemia_Homo sapiens_hsa052210.51493231
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51443721
140Influenza A_Homo sapiens_hsa051640.50872351
141HTLV-I infection_Homo sapiens_hsa051660.50763720
142Mineral absorption_Homo sapiens_hsa049780.50243830
143Tight junction_Homo sapiens_hsa045300.49764103
144Viral carcinogenesis_Homo sapiens_hsa052030.47805595
145PPAR signaling pathway_Homo sapiens_hsa033200.47003684
146Glucagon signaling pathway_Homo sapiens_hsa049220.45053547
147Vitamin B6 metabolism_Homo sapiens_hsa007500.42846264

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