ADAM18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.95454062
2epithelial cilium movement (GO:0003351)9.77370267
3piRNA metabolic process (GO:0034587)9.58944025
4male meiosis (GO:0007140)9.07623041
5motile cilium assembly (GO:0044458)8.98222105
6spermatid development (GO:0007286)8.95855356
7cilium movement (GO:0003341)8.71125998
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.45693045
9synaptonemal complex organization (GO:0070193)8.02451506
10regulation of cilium movement (GO:0003352)7.96123018
11synaptonemal complex assembly (GO:0007130)7.84150652
12single fertilization (GO:0007338)7.79202909
13sperm capacitation (GO:0048240)7.47381696
14fertilization (GO:0009566)6.46980179
15DNA methylation involved in gamete generation (GO:0043046)6.01787011
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)5.78311456
17ventricular system development (GO:0021591)5.74260593
18* spermatogenesis (GO:0007283)5.69020599
19* male gamete generation (GO:0048232)5.66999879
20negative regulation of inclusion body assembly (GO:0090084)5.63094227
21chromosome organization involved in meiosis (GO:0070192)5.56568894
22male meiosis I (GO:0007141)5.44792277
23transmission of nerve impulse (GO:0019226)5.42623901
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.28126210
25regulation of female receptivity (GO:0045924)5.25396236
26* gamete generation (GO:0007276)5.21073479
27cell recognition (GO:0008037)5.19351328
28germ cell development (GO:0007281)5.11337330
29microtubule depolymerization (GO:0007019)5.08639977
30organic cation transport (GO:0015695)5.08014936
31microtubule severing (GO:0051013)5.04999958
32meiotic nuclear division (GO:0007126)5.02745446
33calcium ion-dependent exocytosis (GO:0017156)4.96087932
34female mating behavior (GO:0060180)4.79840909
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.79558838
36regulation of microtubule-based movement (GO:0060632)4.66628769
37spermatid nucleus differentiation (GO:0007289)4.64069266
38regulation of inclusion body assembly (GO:0090083)4.62287712
39seminiferous tubule development (GO:0072520)4.48192136
40protein localization to cilium (GO:0061512)4.42207445
41indole-containing compound catabolic process (GO:0042436)4.40485813
42indolalkylamine catabolic process (GO:0046218)4.40485813
43tryptophan catabolic process (GO:0006569)4.40485813
44response to pheromone (GO:0019236)4.39237321
45monoubiquitinated protein deubiquitination (GO:0035520)4.37538230
46meiosis I (GO:0007127)4.37509301
47DNA double-strand break processing (GO:0000729)4.36331718
48negative regulation of synaptic transmission, GABAergic (GO:0032229)4.35039888
49indolalkylamine metabolic process (GO:0006586)4.34383111
50adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.33058395
51detection of light stimulus involved in sensory perception (GO:0050962)4.24078108
52detection of light stimulus involved in visual perception (GO:0050908)4.24078108
53tryptophan metabolic process (GO:0006568)4.21019132
54protein polyglutamylation (GO:0018095)4.14131916
55dopamine transport (GO:0015872)4.12007536
56* multicellular organismal reproductive process (GO:0048609)4.08307868
57signal peptide processing (GO:0006465)4.06552885
58L-methionine salvage (GO:0071267)4.05023333
59L-methionine biosynthetic process (GO:0071265)4.05023333
60amino acid salvage (GO:0043102)4.05023333
61meiotic cell cycle (GO:0051321)4.00209537
62meiotic chromosome segregation (GO:0045132)3.96965952
63kynurenine metabolic process (GO:0070189)3.95754318
64left/right pattern formation (GO:0060972)3.86729781
65photoreceptor cell maintenance (GO:0045494)3.84216627
66intraciliary transport (GO:0042073)3.84168138
67regulation of hippo signaling (GO:0035330)3.82142897
68genitalia morphogenesis (GO:0035112)3.79927108
69replication fork processing (GO:0031297)3.79460042
70detection of mechanical stimulus involved in sensory perception (GO:0050974)3.77914115
71negative regulation of cytosolic calcium ion concentration (GO:0051481)3.70230126
72opioid receptor signaling pathway (GO:0038003)3.60314835
73synapsis (GO:0007129)3.55308842
74negative regulation of organelle assembly (GO:1902116)3.54612008
75gene silencing by RNA (GO:0031047)3.52823279
76cellular biogenic amine catabolic process (GO:0042402)3.52223151
77amine catabolic process (GO:0009310)3.52223151
78positive regulation of cAMP-mediated signaling (GO:0043950)3.48492779
79glycerol ether metabolic process (GO:0006662)3.47674122
80chaperone-mediated protein complex assembly (GO:0051131)3.46824608
81microtubule-based movement (GO:0007018)3.40456643
82behavioral response to ethanol (GO:0048149)3.32957824
83lactate metabolic process (GO:0006089)3.31578006
84* multicellular organismal development (GO:0007275)3.30210834
85axoneme assembly (GO:0035082)3.29100825
86regulation of centriole replication (GO:0046599)3.27115938
87regulation of posttranscriptional gene silencing (GO:0060147)3.26504729
88regulation of gene silencing by miRNA (GO:0060964)3.26504729
89regulation of gene silencing by RNA (GO:0060966)3.26504729
90keratinocyte development (GO:0003334)3.23894241
91amino-acid betaine transport (GO:0015838)3.23650216
92carnitine transport (GO:0015879)3.23650216
93carnitine transmembrane transport (GO:1902603)3.22263346
94ether metabolic process (GO:0018904)3.20876193
95cilium organization (GO:0044782)3.19698934
96negative regulation of astrocyte differentiation (GO:0048712)3.19271543
97protein-chromophore linkage (GO:0018298)3.15253851
98meiotic cell cycle process (GO:1903046)3.14450260
99somite development (GO:0061053)3.14351395
100sulfation (GO:0051923)3.14147390
101protein K11-linked deubiquitination (GO:0035871)3.11375058
102indole-containing compound metabolic process (GO:0042430)3.11016524
103sensory perception of smell (GO:0007608)3.08324323
104neuronal action potential (GO:0019228)3.07888538
105nonmotile primary cilium assembly (GO:0035058)3.07793906
106otic vesicle formation (GO:0030916)3.05433223
107tachykinin receptor signaling pathway (GO:0007217)3.04852788
108cellular component assembly involved in morphogenesis (GO:0010927)3.04280772
109cilium assembly (GO:0042384)3.04048514
110primary amino compound metabolic process (GO:1901160)3.03297919
111vocalization behavior (GO:0071625)3.02859967
112methionine biosynthetic process (GO:0009086)3.02643882
113centriole assembly (GO:0098534)3.01002365
114behavioral response to cocaine (GO:0048148)3.00760420
115centriole replication (GO:0007099)2.98006043
116alditol metabolic process (GO:0019400)2.97189951
117serotonin metabolic process (GO:0042428)2.95841416
118polyol catabolic process (GO:0046174)2.94921902
119cilium morphogenesis (GO:0060271)2.93909914
120regulation of spindle checkpoint (GO:0090231)2.93494440
121gamma-aminobutyric acid transport (GO:0015812)2.92627356
122urinary tract smooth muscle contraction (GO:0014848)2.90278493
123peristalsis (GO:0030432)2.89605531
124chromosome condensation (GO:0030261)2.88491638
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88323666
126negative regulation of sodium ion transport (GO:0010766)2.87429792
127gamma-aminobutyric acid signaling pathway (GO:0007214)2.84181848
128tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82525363
129RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82525363
130lateral sprouting from an epithelium (GO:0060601)2.82384961
131nucleoside diphosphate phosphorylation (GO:0006165)2.82322935
132negative regulation of response to food (GO:0032096)2.80806739
133negative regulation of appetite (GO:0032099)2.80806739
134fucose catabolic process (GO:0019317)2.80149871
135L-fucose metabolic process (GO:0042354)2.80149871
136L-fucose catabolic process (GO:0042355)2.80149871
137synaptic vesicle endocytosis (GO:0048488)2.78333797
138negative regulation of T cell receptor signaling pathway (GO:0050860)2.78115758
139detection of mechanical stimulus (GO:0050982)2.77839721
140synaptic transmission, dopaminergic (GO:0001963)2.77790603
141DNA packaging (GO:0006323)2.76080249
142nuclear pore complex assembly (GO:0051292)2.74962307
143embryonic epithelial tube formation (GO:0001838)2.73687820
144peptidyl-glutamic acid modification (GO:0018200)2.72256715
145phasic smooth muscle contraction (GO:0014821)2.71731950
146pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.71242170
147UMP metabolic process (GO:0046049)2.71242170
148pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.71242170
149UMP biosynthetic process (GO:0006222)2.71242170
150glycolytic process (GO:0006096)2.69551897
151glycerol metabolic process (GO:0006071)2.66670857
152intestinal epithelial cell development (GO:0060576)2.64606362
153protein refolding (GO:0042026)2.64164128
154snRNA transcription (GO:0009301)2.63816494
155maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63651122
156methionine metabolic process (GO:0006555)2.63220484
157regulation of protein polyubiquitination (GO:1902914)2.62477169
158limb development (GO:0060173)2.61961232
159appendage development (GO:0048736)2.61961232
160negative regulation of cAMP-mediated signaling (GO:0043951)2.61911167
161negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.61182155
162microtubule polymerization or depolymerization (GO:0031109)2.60976766
163reflex (GO:0060004)2.60593342
164auditory receptor cell stereocilium organization (GO:0060088)2.60110615
165GTP biosynthetic process (GO:0006183)2.59547782
166rhodopsin mediated signaling pathway (GO:0016056)2.58154604
167nephron tubule formation (GO:0072079)2.57549226
168left/right axis specification (GO:0070986)2.57318298
169regulation of meiosis I (GO:0060631)2.55154388
170NAD biosynthetic process (GO:0009435)2.54570567
171regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54198866
172artery development (GO:0060840)2.53753441
173negative regulation of DNA repair (GO:0045738)2.52932287
174nucleus organization (GO:0006997)2.51120194
175gene silencing (GO:0016458)2.48552574
176mitotic sister chromatid cohesion (GO:0007064)2.47158603
177single strand break repair (GO:0000012)2.43802744
178calcium ion import (GO:0070509)2.40346259
179single-organism membrane fusion (GO:0044801)2.34353213
180cilium or flagellum-dependent cell motility (GO:0001539)14.9981442
181fusion of sperm to egg plasma membrane (GO:0007342)14.0896716
182acrosome assembly (GO:0001675)12.7886867
183sperm motility (GO:0030317)12.2243378
184multicellular organism reproduction (GO:0032504)12.2170308
185cell wall macromolecule catabolic process (GO:0016998)11.8827150
186cell wall macromolecule metabolic process (GO:0044036)11.8827150
187sperm-egg recognition (GO:0035036)11.8281329
188plasma membrane fusion (GO:0045026)10.7596465
189axonemal dynein complex assembly (GO:0070286)10.6267378
190cell-cell recognition (GO:0009988)10.6037178
191binding of sperm to zona pellucida (GO:0007339)10.4565840
192acrosome reaction (GO:0007340)10.3292277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.59159669
2EZH2_22144423_ChIP-Seq_EOC_Human4.95621650
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.35063989
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.83913757
5GBX2_23144817_ChIP-Seq_PC3_Human3.05952626
6IGF1R_20145208_ChIP-Seq_DFB_Human2.91378556
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.91286777
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58130878
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52693655
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.52594165
11P300_19829295_ChIP-Seq_ESCs_Human2.47024262
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42691536
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36107781
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34435041
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30681500
16FUS_26573619_Chip-Seq_HEK293_Human2.21541194
17ZNF274_21170338_ChIP-Seq_K562_Hela2.17586436
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1163611
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97744586
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95777403
21EWS_26573619_Chip-Seq_HEK293_Human1.95429891
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95066574
23CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.95062537
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.93276727
25VDR_22108803_ChIP-Seq_LS180_Human1.92529850
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.87800071
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87519156
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.85104083
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84711042
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.80542359
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.79889663
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.76032417
33SMAD4_21799915_ChIP-Seq_A2780_Human1.74329689
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71971728
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69382439
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.68663231
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68038971
38AR_21572438_ChIP-Seq_LNCaP_Human1.67661959
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66058477
40* STAT3_23295773_ChIP-Seq_U87_Human1.65185375
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.64490729
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64425929
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59816980
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58357728
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57869143
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56037818
47BCAT_22108803_ChIP-Seq_LS180_Human1.55403532
48STAT1_17558387_ChIP-Seq_HELA_Human1.53119701
49KDM2B_26808549_Chip-Seq_REH_Human1.53037457
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.52326761
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51523602
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50173134
53AR_25329375_ChIP-Seq_VCAP_Human1.50113400
54CBP_20019798_ChIP-Seq_JUKART_Human1.49070378
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49070378
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48786540
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48551889
58NANOG_19829295_ChIP-Seq_ESCs_Human1.46068361
59SOX2_19829295_ChIP-Seq_ESCs_Human1.46068361
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45302144
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.44505190
62TP53_18474530_ChIP-ChIP_U2OS_Human1.43429926
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.42633368
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41473700
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40728943
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.38983511
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.38484305
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38295386
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.35305349
70RNF2_27304074_Chip-Seq_NSC_Mouse1.34731687
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34449028
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.34337596
73* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33835380
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32228973
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.31837632
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31395897
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.31078342
78* TCF4_22108803_ChIP-Seq_LS180_Human1.30736025
79GATA3_21867929_ChIP-Seq_CD8_Mouse1.28647797
80REST_21632747_ChIP-Seq_MESCs_Mouse1.27976023
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.26478529
82RUNX2_22187159_ChIP-Seq_PCA_Human1.26377660
83P53_22387025_ChIP-Seq_ESCs_Mouse1.24604077
84P300_18555785_Chip-Seq_ESCs_Mouse1.23470679
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22723615
86SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22621424
87* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21721829
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21235026
89JUN_21703547_ChIP-Seq_K562_Human1.21201479
90GATA3_21867929_ChIP-Seq_TH1_Mouse1.20943199
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.20582087
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.20320063
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19645487
94AHR_22903824_ChIP-Seq_MCF-7_Human1.19639047
95TP53_22573176_ChIP-Seq_HFKS_Human1.19266001
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.19087652
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18494090
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18036996
99ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17409514
100* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17195207
101* FOXA1_25329375_ChIP-Seq_VCAP_Human1.17195207
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16987120
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16810550
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15258167
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.15225097
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.14886337
107OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14800544
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14640406
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.12601595
110GF1_26923725_Chip-Seq_HPCs_Mouse1.12092830
111SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11378572
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11219526
113RXR_22108803_ChIP-Seq_LS180_Human1.10699206
114DROSHA_22980978_ChIP-Seq_HELA_Human1.08862999
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08670263
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08142601
117* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07850375
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07693095
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07580984
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.07049782
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.05869901
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05863153
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05816759
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05816759
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05396167
126CTCF_18555785_Chip-Seq_ESCs_Mouse1.05317692
127SMAD3_21741376_ChIP-Seq_ESCs_Human1.04316235
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.03525917
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03142144
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02456283
131SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02263924
132P53_21459846_ChIP-Seq_SAOS-2_Human1.02125892
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.01380059
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01049773
135PU1_27457419_Chip-Seq_LIVER_Mouse0.99945450
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99871814
137TAF15_26573619_Chip-Seq_HEK293_Human0.98586782
138SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97723026
139* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96925091
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96653603
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96632991
142ZFX_18555785_Chip-Seq_ESCs_Mouse0.96124840
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95707064
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.94238636
145FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93512182
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93131123
147NMYC_18555785_Chip-Seq_ESCs_Mouse0.92683449
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.92088198
149ER_23166858_ChIP-Seq_MCF-7_Human0.90171885
150GF1B_26923725_Chip-Seq_HPCs_Mouse0.89615097
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89071778
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88792336
153PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88580536
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87991329
155SOX9_26525672_Chip-Seq_HEART_Mouse0.87894626
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85999598
157* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84692822
158* TCF4_23295773_ChIP-Seq_U87_Human0.83972927
159RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83540050
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81915336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03055457
2MP0001929_abnormal_gametogenesis5.50206120
3MP0008877_abnormal_DNA_methylation5.26341304
4MP0003136_yellow_coat_color4.95980564
5MP0002653_abnormal_ependyma_morphology3.79884352
6MP0002210_abnormal_sex_determination3.75777383
7MP0008789_abnormal_olfactory_epithelium3.50061365
8MP0002161_abnormal_fertility/fecundity3.23040215
9MP0001145_abnormal_male_reproductive3.18403444
10MP0000372_irregular_coat_pigmentation3.17532835
11MP0001485_abnormal_pinna_reflex2.82807819
12MP0005623_abnormal_meninges_morphology2.78064178
13MP0000653_abnormal_sex_gland2.77487499
14MP0006292_abnormal_olfactory_placode2.58523654
15MP0005499_abnormal_olfactory_system2.54628507
16MP0005394_taste/olfaction_phenotype2.54628507
17MP0003938_abnormal_ear_development2.38612438
18MP0000383_abnormal_hair_follicle2.37912286
19MP0001529_abnormal_vocalization2.05618168
20MP0009046_muscle_twitch2.03732861
21MP0006276_abnormal_autonomic_nervous2.01407050
22MP0005410_abnormal_fertilization15.2390236
23MP0009697_abnormal_copulation1.94849744
24MP0002163_abnormal_gland_morphology1.88951102
25MP0009780_abnormal_chondrocyte_physiolo1.87467732
26MP0008057_abnormal_DNA_replication1.84762753
27MP0010030_abnormal_orbit_morphology1.84740030
28MP0005187_abnormal_penis_morphology1.77725405
29MP0009053_abnormal_anal_canal1.76477987
30MP0008775_abnormal_heart_ventricle1.76167927
31MP0002938_white_spotting1.75866312
32MP0002160_abnormal_reproductive_system1.71273875
33MP0004147_increased_porphyrin_level1.66835110
34MP0005646_abnormal_pituitary_gland1.66052317
35MP0000566_synostosis1.62046018
36MP0008872_abnormal_physiological_respon1.57479208
37MP0002735_abnormal_chemical_nociception1.56590357
38MP0002282_abnormal_trachea_morphology1.55157729
39MP0005670_abnormal_white_adipose1.50525665
40MP0008058_abnormal_DNA_repair1.48131907
41MP0003195_calcinosis1.43703229
42MP0004130_abnormal_muscle_cell1.42830563
43MP0010678_abnormal_skin_adnexa1.42761435
44MP0000026_abnormal_inner_ear1.41096253
45MP0003646_muscle_fatigue1.39596588
46MP0000631_abnormal_neuroendocrine_gland1.36560919
47MP0003119_abnormal_digestive_system1.36088245
48MP0002233_abnormal_nose_morphology1.30190850
49MP0001984_abnormal_olfaction1.23185808
50MP0002733_abnormal_thermal_nociception1.23152115
51MP0003718_maternal_effect1.22012109
52MP0004233_abnormal_muscle_weight1.20256123
53MP0005647_abnormal_sex_gland1.17629777
54MP0002909_abnormal_adrenal_gland1.13766630
55MP0000230_abnormal_systemic_arterial1.12939394
56MP0005310_abnormal_salivary_gland1.10060722
57MP0002090_abnormal_vision1.09290825
58MP0005645_abnormal_hypothalamus_physiol1.08461972
59MP0001765_abnormal_ion_homeostasis1.08085278
60MP0003937_abnormal_limbs/digits/tail_de1.06532890
61MP0000049_abnormal_middle_ear1.05986361
62MP0001963_abnormal_hearing_physiology1.03582642
63MP0001486_abnormal_startle_reflex1.02861816
64MP0005248_abnormal_Harderian_gland0.97606061
65MP0001501_abnormal_sleep_pattern0.97385377
66MP0005171_absent_coat_pigmentation0.97330466
67MP0010094_abnormal_chromosome_stability0.97305732
68MP0002557_abnormal_social/conspecific_i0.96635444
69MP0001970_abnormal_pain_threshold0.95762984
70MP0002067_abnormal_sensory_capabilities0.94422802
71MP0005379_endocrine/exocrine_gland_phen0.91936029
72MP0005389_reproductive_system_phenotype0.89815001
73MP0002876_abnormal_thyroid_physiology0.87427319
74MP0000778_abnormal_nervous_system0.85687214
75MP0003011_delayed_dark_adaptation0.85555632
76MP0005395_other_phenotype0.84936730
77MP0001346_abnormal_lacrimal_gland0.84308040
78MP0004885_abnormal_endolymph0.83334859
79MP0003638_abnormal_response/metabolism_0.82621196
80MP0006054_spinal_hemorrhage0.78672693
81MP0001905_abnormal_dopamine_level0.78132672
82MP0002752_abnormal_somatic_nervous0.77527268
83MP0001664_abnormal_digestion0.76004029
84MP0002168_other_aberrant_phenotype0.75284801
85MP0001986_abnormal_taste_sensitivity0.74913351
86MP0001756_abnormal_urination0.74184593
87MP0008995_early_reproductive_senescence0.73059963
88MP0003755_abnormal_palate_morphology0.71032276
89MP0008875_abnormal_xenobiotic_pharmacok0.69268173
90MP0003950_abnormal_plasma_membrane0.68944005
91MP0003786_premature_aging0.68687696
92MP0000428_abnormal_craniofacial_morphol0.67264042
93MP0008007_abnormal_cellular_replicative0.66675948
94MP0005503_abnormal_tendon_morphology0.66074185
95MP0000579_abnormal_nail_morphology0.65192634
96MP0004924_abnormal_behavior0.64998533
97MP0002928_abnormal_bile_duct0.63343434
98MP0000569_abnormal_digit_pigmentation0.59114583
99MP0002234_abnormal_pharynx_morphology0.58235373
100MP0000358_abnormal_cell_content/0.54595981
101MP0003699_abnormal_female_reproductive0.50931354
102MP0002102_abnormal_ear_morphology0.50738747
103MP0005636_abnormal_mineral_homeostasis0.50591438
104MP0004036_abnormal_muscle_relaxation0.49873846
105MP0003633_abnormal_nervous_system0.49391415
106MP0005551_abnormal_eye_electrophysiolog0.48314890
107MP0004134_abnormal_chest_morphology0.47863876
108MP0001545_abnormal_hematopoietic_system0.46275928
109MP0005397_hematopoietic_system_phenotyp0.46275928
110MP0010307_abnormal_tumor_latency0.45645720
111MP0000427_abnormal_hair_cycle0.44827381
112MP0005377_hearing/vestibular/ear_phenot0.44534687
113MP0003878_abnormal_ear_physiology0.44534687
114MP0005253_abnormal_eye_physiology0.43701462
115MP0001119_abnormal_female_reproductive0.43630494
116MP0001324_abnormal_eye_pigmentation0.43429435
117MP0004808_abnormal_hematopoietic_stem0.41900365
118MP0003329_amyloid_beta_deposits0.41336632
119MP0003115_abnormal_respiratory_system0.37134439
120MP0004019_abnormal_vitamin_homeostasis0.36491135
121MP0001293_anophthalmia0.36227174
122MP0003631_nervous_system_phenotype0.34808715
123MP0002736_abnormal_nociception_after0.33307988
124MP0004811_abnormal_neuron_physiology0.32887500
125MP0003787_abnormal_imprinting0.32676006
126MP0009278_abnormal_bone_marrow0.31877190
127MP0001764_abnormal_homeostasis0.31334020
128MP0002572_abnormal_emotion/affect_behav0.31261487
129MP0004133_heterotaxia0.30887760
130MP0002152_abnormal_brain_morphology0.30112854
131MP0005391_vision/eye_phenotype0.29871722
132MP0002971_abnormal_brown_adipose0.28981523
133MP0003111_abnormal_nucleus_morphology0.28378280
134MP0006036_abnormal_mitochondrial_physio0.27562289
135MP0003861_abnormal_nervous_system0.26376975
136MP0003879_abnormal_hair_cell0.25825746
137MP0001730_embryonic_growth_arrest0.25698972
138MP0002269_muscular_atrophy0.25351212
139MP0001968_abnormal_touch/_nociception0.24487682
140MP0000313_abnormal_cell_death0.24415584
141MP0001440_abnormal_grooming_behavior0.24300560
142MP0003635_abnormal_synaptic_transmissio0.23834808
143MP0009745_abnormal_behavioral_response0.23293119
144MP0002837_dystrophic_cardiac_calcinosis0.22690787
145MP0004084_abnormal_cardiac_muscle0.22216478
146MP0002229_neurodegeneration0.21629225
147MP0005666_abnormal_adipose_tissue0.21577704
148MP0009115_abnormal_fat_cell0.21038348
149MP0004270_analgesia0.20617488
150MP0003045_fibrosis0.19860904
151MP0006138_congestive_heart_failure0.19141962
152MP0004043_abnormal_pH_regulation0.19035942
153MP0000647_abnormal_sebaceous_gland0.18889890
154MP0000604_amyloidosis0.18341407
155MP0003183_abnormal_peptide_metabolism0.18245921
156MP0006072_abnormal_retinal_apoptosis0.17829129
157MP0002064_seizures0.16835085
158MP0005195_abnormal_posterior_eye0.16008222
159MP0002272_abnormal_nervous_system0.15851936
160MP0002084_abnormal_developmental_patter0.14691621
161MP0008569_lethality_at_weaning0.14666294
162MP0001851_eye_inflammation0.14640247
163MP0002063_abnormal_learning/memory/cond0.14515566
164MP0002405_respiratory_system_inflammati0.14378011
165MP0001727_abnormal_embryo_implantation0.14257970
166MP0002169_no_abnormal_phenotype0.14242142
167MP0002873_normal_phenotype0.14088454
168MP0002132_abnormal_respiratory_system0.13841289

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.67267937
2Abnormal respiratory epithelium morphology (HP:0012253)8.65428560
3Abnormal respiratory motile cilium morphology (HP:0005938)8.65428560
4Abnormal ciliary motility (HP:0012262)8.05179234
5Rhinitis (HP:0012384)8.04995810
6Chronic bronchitis (HP:0004469)7.29281469
7Nasal polyposis (HP:0100582)6.45557090
8Infertility (HP:0000789)6.02428487
9Abnormality of the nasal mucosa (HP:0000433)5.29406688
10Bronchiectasis (HP:0002110)4.63783309
11Bronchitis (HP:0012387)4.60165289
12Nephronophthisis (HP:0000090)4.42997692
13Bony spicule pigmentary retinopathy (HP:0007737)4.35860434
14Attenuation of retinal blood vessels (HP:0007843)3.61350782
15Recurrent sinusitis (HP:0011108)3.59236549
16Abolished electroretinogram (ERG) (HP:0000550)3.57417590
17Male infertility (HP:0003251)3.43051492
18Pancreatic cysts (HP:0001737)3.42738326
19Proximal tubulopathy (HP:0000114)3.41092960
20Abnormality of the renal medulla (HP:0100957)3.36344452
21Recurrent otitis media (HP:0000403)3.35869216
22Abnormality of the lower motor neuron (HP:0002366)3.11100236
23Abnormal spermatogenesis (HP:0008669)3.09899934
24Medial flaring of the eyebrow (HP:0010747)3.02927848
25Keratoconus (HP:0000563)3.02789287
26Increased corneal curvature (HP:0100692)3.02789287
273-Methylglutaconic aciduria (HP:0003535)2.98030187
28Recurrent bronchitis (HP:0002837)2.80754503
29Abnormality of midbrain morphology (HP:0002418)2.79691421
30Molar tooth sign on MRI (HP:0002419)2.79691421
31Tubulointerstitial nephritis (HP:0001970)2.74761305
32Adactyly (HP:0009776)2.73925993
33Congenital stationary night blindness (HP:0007642)2.68788762
34Short 1st metacarpal (HP:0010034)2.67686729
35Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.67686729
36Hyperventilation (HP:0002883)2.66767694
37Tubular atrophy (HP:0000092)2.56104132
38Long nose (HP:0003189)2.51238071
39Renal cortical cysts (HP:0000803)2.50534261
40Severe Myopia (HP:0011003)2.50405475
41Chronic hepatic failure (HP:0100626)2.47370744
42Gonadotropin excess (HP:0000837)2.46435215
43Amyotrophic lateral sclerosis (HP:0007354)2.44486189
44Hypoplastic ischia (HP:0003175)2.44237406
45Colon cancer (HP:0003003)2.42869898
46Tubulointerstitial abnormality (HP:0001969)2.42198014
47Fibular hypoplasia (HP:0003038)2.41732466
48Azoospermia (HP:0000027)2.38276538
49Abnormality of alanine metabolism (HP:0010916)2.37603670
50Hyperalaninemia (HP:0003348)2.37603670
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37603670
52Abnormality of the 1st metacarpal (HP:0010009)2.31796480
53Hypoplastic iliac wings (HP:0002866)2.30880250
54Hypothermia (HP:0002045)2.25068389
55Postaxial foot polydactyly (HP:0001830)2.21967868
56Abnormality of the ischium (HP:0003174)2.20878037
57Optic nerve hypoplasia (HP:0000609)2.20185187
58Microglossia (HP:0000171)2.15583201
59Short phalanx of the thumb (HP:0009660)2.15362759
60Hyperglycinuria (HP:0003108)2.13189356
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12591158
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12555390
63Abnormality of the labia minora (HP:0012880)2.11264562
64Chorioretinal atrophy (HP:0000533)2.10182311
65Absent frontal sinuses (HP:0002688)2.10085211
66Rectovaginal fistula (HP:0000143)2.09706320
67Rectal fistula (HP:0100590)2.09706320
68Retinitis pigmentosa (HP:0000510)2.09485399
69Cerebellar dysplasia (HP:0007033)2.09369945
70Pendular nystagmus (HP:0012043)2.08721242
71Congenital hepatic fibrosis (HP:0002612)2.08190516
72Thyroid-stimulating hormone excess (HP:0002925)2.04914683
73Short hallux (HP:0010109)2.04445981
74Hyperglycinemia (HP:0002154)2.01831446
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.00579009
76Hypoplasia of the fovea (HP:0007750)2.00579009
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.1292624
78Absent/shortened dynein arms (HP:0200106)12.4155938
79Dynein arm defect of respiratory motile cilia (HP:0012255)12.4155938
80Tubulointerstitial fibrosis (HP:0005576)1.99937547
81J-shaped sella turcica (HP:0002680)1.99100835
82Impulsivity (HP:0100710)1.98967158
83Concave nail (HP:0001598)1.97435384
84Soft skin (HP:0000977)1.95758843
85Chronic sinusitis (HP:0011109)1.93330971
86Left ventricular hypertrophy (HP:0001712)1.92057776
87Sclerocornea (HP:0000647)1.91444117
88Stage 5 chronic kidney disease (HP:0003774)1.91003037
89Severe visual impairment (HP:0001141)1.89491674
90Type II lissencephaly (HP:0007260)1.89106427
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88653357
92Abnormal protein glycosylation (HP:0012346)1.87459855
93Abnormal glycosylation (HP:0012345)1.87459855
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87459855
95Abnormal protein N-linked glycosylation (HP:0012347)1.87459855
96Abnormal drinking behavior (HP:0030082)1.87458551
97Polydipsia (HP:0001959)1.87458551
98Gait imbalance (HP:0002141)1.86457729
99Impaired proprioception (HP:0010831)1.86032657
100Congenital primary aphakia (HP:0007707)1.85822027
101Short ribs (HP:0000773)1.83956586
102Pancreatic fibrosis (HP:0100732)1.83738523
103Furrowed tongue (HP:0000221)1.83081428
104Progressive cerebellar ataxia (HP:0002073)1.82174611
105Facial cleft (HP:0002006)1.81725417
106Abnormality of the renal cortex (HP:0011035)1.81408211
107Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.81344921
108Broad foot (HP:0001769)1.80479980
109Hemiparesis (HP:0001269)1.80027928
110Absent speech (HP:0001344)1.79473667
111Broad-based gait (HP:0002136)1.79045927
112Renal dysplasia (HP:0000110)1.78917485
113Genetic anticipation (HP:0003743)1.78865717
114Megalencephaly (HP:0001355)1.78743194
115Aplasia/Hypoplasia of the hallux (HP:0008362)1.76353237
116Short foot (HP:0001773)1.75452065
117Median cleft lip (HP:0000161)1.75419537
118Oculomotor apraxia (HP:0000657)1.75091948
119Postaxial hand polydactyly (HP:0001162)1.74893577
120Generalized aminoaciduria (HP:0002909)1.74820468
121Hematochezia (HP:0002573)1.74236499
122Abnormality of the antihelix (HP:0009738)1.74103591
123Aplasia/Hypoplasia of the nipples (HP:0006709)1.73708779
124Congenital sensorineural hearing impairment (HP:0008527)1.73654108
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.71070874
126Upper motor neuron abnormality (HP:0002127)1.70947173
127Abnormality of the dental root (HP:0006486)1.70380132
128Taurodontia (HP:0000679)1.70380132
129Abnormality of permanent molar morphology (HP:0011071)1.70380132
130Abnormality of molar (HP:0011077)1.60739945
131Abnormality of molar morphology (HP:0011070)1.60739945
132Abnormality of dentin (HP:0010299)1.60486458
133Abnormality of ocular smooth pursuit (HP:0000617)1.60278057
134Nephrogenic diabetes insipidus (HP:0009806)1.59112604
135Abnormality of renal excretion (HP:0011036)1.58113200
136Abnormality of saccadic eye movements (HP:0000570)1.58061756
137Abnormality of the dental pulp (HP:0006479)1.53774401
138Tongue fasciculations (HP:0001308)1.52715859
139Supernumerary spleens (HP:0009799)1.51862751
140Cystic liver disease (HP:0006706)1.51698283
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51339673
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49967093
143Absent epiphyses (HP:0010577)1.49967093
144Spastic tetraparesis (HP:0001285)1.49782081
145Deformed sella turcica (HP:0002681)1.49450599
146Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.48758973
147Aplasia/Hypoplasia of the fibula (HP:0006492)1.48705011
148Degeneration of anterior horn cells (HP:0002398)1.47803453
149Abnormality of the anterior horn cell (HP:0006802)1.47803453
150Short thorax (HP:0010306)1.45736644
151Abnormal gallbladder physiology (HP:0012438)1.44640064
152Cholecystitis (HP:0001082)1.44640064
153Genital tract atresia (HP:0001827)1.43815100
154Bile duct proliferation (HP:0001408)1.42263257
155Abnormal biliary tract physiology (HP:0012439)1.42263257
156Heterotopia (HP:0002282)1.40831059
157Decreased central vision (HP:0007663)1.40684550
158Poor coordination (HP:0002370)1.39223370
159Aplasia/Hypoplasia of the lens (HP:0008063)1.39087124
160Muscle fibrillation (HP:0010546)1.36621599
161Bell-shaped thorax (HP:0001591)1.34992391
162Vaginal atresia (HP:0000148)1.34899765
163Nephropathy (HP:0000112)1.33806141
16411 pairs of ribs (HP:0000878)1.33653097
165Dyschromatopsia (HP:0007641)1.32921841
166True hermaphroditism (HP:0010459)1.32758972
167Breast carcinoma (HP:0003002)1.31122514
168Pachygyria (HP:0001302)1.29782542
169Gaze-evoked nystagmus (HP:0000640)1.29002522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.22119135
2PDK39.22119135
3FRK6.30023559
4PDK25.97945595
5ADRBK24.61322137
6TESK14.15749217
7PRKD33.41718195
8NUAK13.35589853
9ICK2.74630286
10PTK2B2.73391276
11WNK42.65150064
12STK392.63857881
13PNCK2.32160327
14NTRK32.06923609
15INSRR2.02718597
16VRK21.93823408
17DAPK21.84107688
18CASK1.70631679
19ZAK1.67512730
20NEK21.59063057
21PAK31.58346492
22GRK11.55861999
23ACVR1B1.55722322
24MAPK131.54808149
25PIK3CA1.48437662
26TNIK1.47412171
27EPHA31.44592659
28STK381.42176653
29TGFBR11.37044841
30PLK21.35939370
31DAPK11.34009469
32VRK11.32161715
33TXK1.30594530
34NLK1.24082519
35LATS11.22026724
36TRIM281.16935699
37CSNK1G31.15999480
38ADRBK11.15127559
39PRKCE1.14720065
40MST41.14143128
41WNK11.10837536
42PIK3CG1.07805384
43MAP4K21.06183281
44CCNB11.03107390
45BCKDK1.02930821
46CSNK1G21.02434241
47PDK11.01491256
48CSNK1A1L1.01165090
49CSNK1G10.98147598
50DYRK20.97352557
51MAPK150.96536554
52TYRO30.94917068
53MYLK0.89651405
54BCR0.89463202
55WEE10.82359584
56STK30.81317620
57FGFR20.81122792
58NME10.78812340
59DYRK1B0.78376667
60LMTK20.76827331
61EPHB20.72507907
62PASK0.71864338
63CDC70.69168361
64PLK30.65318701
65TTK0.63122505
66DAPK30.59517859
67STK38L0.59281458
68DYRK30.59078537
69MAP2K70.55634713
70CHEK20.55396058
71IRAK10.54148155
72CDK80.51967313
73FER0.51931754
74CHEK10.50607818
75EPHA40.50522100
76BRSK20.50126676
77MAP3K70.49584165
78ERBB20.49065871
79GRK50.48247811
80DYRK1A0.47802850
81FLT30.47752753
82PINK10.47028116
83PRKAA20.46914193
84ATR0.46375172
85CAMK1G0.45085989
86PLK40.43382692
87PDPK10.41275106
88MKNK20.40421138
89TLK10.40241294
90MAP3K40.38054946
91RIPK40.37177652
92BUB10.36677008
93TESK20.34228913
94CHUK0.34202798
95PRKCG0.33395812
96ATM0.33026901
97CDK70.32664499
98MAP2K10.32185651
99TIE10.32165338
100MAP2K60.31919281
101KIT0.29361927
102MKNK10.28617501
103NTRK20.28525343
104BMPR1B0.28496841
105CDK120.27495095
106PAK10.26087828
107MAPKAPK50.25317667
108BMX0.24752341
109CAMKK10.23951735
110MELK0.23474136
111NEK60.23383155
112CDK50.23373717
113FGR0.21994182
114PLK10.21798377
115ABL10.21314121
116ZAP700.20454108
117RPS6KB10.18546059
118EEF2K0.18249702
119BRSK10.17459041
120MTOR0.16657893
121PRKAA10.16186238
122MUSK0.16044389
123OXSR10.14207086
124PDGFRB0.12450720
125PRKCQ0.12217867
126IRAK20.11632244
127MARK20.11446729
128PAK20.11178977
129STK110.10303402
130WNK30.10071500
131CDK30.10018011
132MARK30.09635314
133PRKG10.08641100
134CDK150.07448150
135PRKCZ0.06877527
136CDK10.06219115
137MAPK80.05929447
138CDK180.05622320
139PAK60.05582516
140CAMK2A0.05398373
141CSNK2A10.05365982
142PRKACG0.05319445
143PRKDC0.05299936
144CDK11A0.05278841
145GSK3B0.05123869
146MAP2K40.04745705
147CSNK1D0.04544465
148CSF1R0.03998111
149CDK20.03752676
150CSNK2A20.03686379
151PRKG20.03525151
152BRAF0.03256087
153MAPK100.02588648
154EGFR0.02251671
155CDK140.02110883
156PRKACB0.01911799
157MINK10.01835731
158RIPK10.01724415
159PKN10.01553148
160PRKCB0.01089922
161STK100.00328269
162YES1-0.0125373
163RPS6KA1-0.0091977
164MARK1-0.0075403
165PRKCA-0.0057733

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.72874527
2Pyruvate metabolism_Homo sapiens_hsa006204.25416352
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.12144029
4Nicotine addiction_Homo sapiens_hsa050333.75045503
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.45909557
6Propanoate metabolism_Homo sapiens_hsa006403.34630407
7Pentose phosphate pathway_Homo sapiens_hsa000303.27264711
8Fatty acid biosynthesis_Homo sapiens_hsa000613.02803246
9Nitrogen metabolism_Homo sapiens_hsa009102.89471968
10Glucagon signaling pathway_Homo sapiens_hsa049222.87588693
11Basal transcription factors_Homo sapiens_hsa030222.81971962
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.66114618
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.58499989
14Phototransduction_Homo sapiens_hsa047442.38466208
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35015244
16Fanconi anemia pathway_Homo sapiens_hsa034602.32053600
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.29935937
18Dorso-ventral axis formation_Homo sapiens_hsa043202.28120510
19Linoleic acid metabolism_Homo sapiens_hsa005912.27629416
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22624218
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.19461864
22Butanoate metabolism_Homo sapiens_hsa006502.14914092
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12665140
24Tryptophan metabolism_Homo sapiens_hsa003802.09076580
25Selenocompound metabolism_Homo sapiens_hsa004502.04014028
26Morphine addiction_Homo sapiens_hsa050322.03647022
27Oocyte meiosis_Homo sapiens_hsa041142.02291261
28Huntingtons disease_Homo sapiens_hsa050161.98768575
29Retinol metabolism_Homo sapiens_hsa008301.94135183
30Glycerolipid metabolism_Homo sapiens_hsa005611.89068623
31GABAergic synapse_Homo sapiens_hsa047271.87251676
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.81897463
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.79029849
34Amphetamine addiction_Homo sapiens_hsa050311.75494622
35p53 signaling pathway_Homo sapiens_hsa041151.58558083
36One carbon pool by folate_Homo sapiens_hsa006701.57967064
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57645979
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57245666
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56349946
40Carbon metabolism_Homo sapiens_hsa012001.56349568
41Renin secretion_Homo sapiens_hsa049241.52449572
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.50906872
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50632510
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48871781
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48227670
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47824387
47PPAR signaling pathway_Homo sapiens_hsa033201.46237159
48Basal cell carcinoma_Homo sapiens_hsa052171.36526218
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.32744476
50Biosynthesis of amino acids_Homo sapiens_hsa012301.27557687
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25374329
52Cardiac muscle contraction_Homo sapiens_hsa042601.25124460
53Fructose and mannose metabolism_Homo sapiens_hsa000511.23954584
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18201163
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16606495
56Folate biosynthesis_Homo sapiens_hsa007901.14366665
57Renin-angiotensin system_Homo sapiens_hsa046141.11775210
58Long-term potentiation_Homo sapiens_hsa047201.11284563
59mRNA surveillance pathway_Homo sapiens_hsa030151.11040672
60Non-homologous end-joining_Homo sapiens_hsa034501.08815110
61Ether lipid metabolism_Homo sapiens_hsa005651.06623849
62Hippo signaling pathway_Homo sapiens_hsa043901.05922279
63RNA polymerase_Homo sapiens_hsa030201.05750756
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05639827
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04870306
66Drug metabolism - other enzymes_Homo sapiens_hsa009831.03211712
67Oxidative phosphorylation_Homo sapiens_hsa001901.01826411
68Mineral absorption_Homo sapiens_hsa049781.00156582
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99913845
70RNA transport_Homo sapiens_hsa030130.99545965
71Fat digestion and absorption_Homo sapiens_hsa049750.98650337
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91803421
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90686674
74Purine metabolism_Homo sapiens_hsa002300.90163951
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.89576540
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89475044
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88813524
78Collecting duct acid secretion_Homo sapiens_hsa049660.88659831
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85491731
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81425549
81Antigen processing and presentation_Homo sapiens_hsa046120.81034472
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79515916
83Sulfur relay system_Homo sapiens_hsa041220.77955800
84Fatty acid metabolism_Homo sapiens_hsa012120.77184196
85Calcium signaling pathway_Homo sapiens_hsa040200.76560905
86ABC transporters_Homo sapiens_hsa020100.75844832
87Starch and sucrose metabolism_Homo sapiens_hsa005000.74378349
88Fatty acid degradation_Homo sapiens_hsa000710.74143485
89Synaptic vesicle cycle_Homo sapiens_hsa047210.73510256
90Estrogen signaling pathway_Homo sapiens_hsa049150.72463760
91Regulation of autophagy_Homo sapiens_hsa041400.71326756
92Insulin secretion_Homo sapiens_hsa049110.68386624
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67927491
94TGF-beta signaling pathway_Homo sapiens_hsa043500.67800952
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65388670
96Taste transduction_Homo sapiens_hsa047420.64861979
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63262871
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62975454
99beta-Alanine metabolism_Homo sapiens_hsa004100.62632434
100Serotonergic synapse_Homo sapiens_hsa047260.61556813
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61092879
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60679632
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60498054
104Parkinsons disease_Homo sapiens_hsa050120.60017559
105Arginine and proline metabolism_Homo sapiens_hsa003300.58010441
106Peroxisome_Homo sapiens_hsa041460.52597321
107Inositol phosphate metabolism_Homo sapiens_hsa005620.52560957
108Ovarian steroidogenesis_Homo sapiens_hsa049130.52400138
109Pyrimidine metabolism_Homo sapiens_hsa002400.52197694
110Glutathione metabolism_Homo sapiens_hsa004800.50795832
111Circadian entrainment_Homo sapiens_hsa047130.49610415
112Chemical carcinogenesis_Homo sapiens_hsa052040.48841500
113Thyroid hormone synthesis_Homo sapiens_hsa049180.48277408
114Caffeine metabolism_Homo sapiens_hsa002320.47977605
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.47566794
116N-Glycan biosynthesis_Homo sapiens_hsa005100.46485737
117Olfactory transduction_Homo sapiens_hsa047400.45113402
118Endocytosis_Homo sapiens_hsa041440.45099131
119Alzheimers disease_Homo sapiens_hsa050100.44222067
120Cell cycle_Homo sapiens_hsa041100.43787484
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.42952287
122VEGF signaling pathway_Homo sapiens_hsa043700.40181256
123ECM-receptor interaction_Homo sapiens_hsa045120.38988386
124Histidine metabolism_Homo sapiens_hsa003400.38980318
125Arachidonic acid metabolism_Homo sapiens_hsa005900.38847859
126Salivary secretion_Homo sapiens_hsa049700.37888359
127Circadian rhythm_Homo sapiens_hsa047100.37873729
128Systemic lupus erythematosus_Homo sapiens_hsa053220.37860814
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37604826
130AMPK signaling pathway_Homo sapiens_hsa041520.37370367
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37240452
132Homologous recombination_Homo sapiens_hsa034400.36564760
133Glutamatergic synapse_Homo sapiens_hsa047240.36473764
134Lysine degradation_Homo sapiens_hsa003100.35754091
135Hedgehog signaling pathway_Homo sapiens_hsa043400.35435715
136Metabolic pathways_Homo sapiens_hsa011000.35026966
137Bile secretion_Homo sapiens_hsa049760.34501499
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.33974594
139Protein export_Homo sapiens_hsa030600.33799091
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33132301
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32738795
142Pancreatic secretion_Homo sapiens_hsa049720.32354384
143Gastric acid secretion_Homo sapiens_hsa049710.32185517
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30733137
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30268575
146cAMP signaling pathway_Homo sapiens_hsa040240.29021728
147Legionellosis_Homo sapiens_hsa051340.23992804
148RNA degradation_Homo sapiens_hsa030180.23024514
149Dopaminergic synapse_Homo sapiens_hsa047280.22736365
150Cocaine addiction_Homo sapiens_hsa050300.22242371
151Wnt signaling pathway_Homo sapiens_hsa043100.19508071
152B cell receptor signaling pathway_Homo sapiens_hsa046620.17678707
153Salmonella infection_Homo sapiens_hsa051320.17418110
154Protein digestion and absorption_Homo sapiens_hsa049740.16684414
155Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16065346
156Sulfur metabolism_Homo sapiens_hsa009200.15268134
157Viral carcinogenesis_Homo sapiens_hsa052030.15095045
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15050866

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