ADAM19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)4.75086907
2cytidine catabolic process (GO:0006216)4.75086907
3cytidine deamination (GO:0009972)4.75086907
4pyrimidine ribonucleoside catabolic process (GO:0046133)4.69227063
5positive regulation of interleukin-8 secretion (GO:2000484)4.13378137
6cellular response to interleukin-15 (GO:0071350)3.80084057
7DNA deamination (GO:0045006)3.67691688
8production of molecular mediator involved in inflammatory response (GO:0002532)3.57841038
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54154172
10regulation of T-helper 1 cell differentiation (GO:0045625)3.51825368
11regulation of dendritic cell antigen processing and presentation (GO:0002604)3.51288384
12endodermal cell differentiation (GO:0035987)3.28244496
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26570191
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22822278
15negative regulation of cell killing (GO:0031342)3.22822278
16polarized epithelial cell differentiation (GO:0030859)3.17554349
17T cell migration (GO:0072678)3.15527486
18negative regulation of viral genome replication (GO:0045071)3.14555830
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13695418
20basement membrane organization (GO:0071711)3.11218074
21antigen processing and presentation of endogenous antigen (GO:0019883)3.10188883
22positive regulation of defense response to virus by host (GO:0002230)3.08531954
23positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.07015411
24bone trabecula formation (GO:0060346)3.05784314
25regulation of interleukin-8 secretion (GO:2000482)3.05258258
26regulation of tight junction assembly (GO:2000810)3.04880603
27dendritic cell migration (GO:0036336)3.03465587
28hippo signaling (GO:0035329)2.98287159
29regulation of B cell receptor signaling pathway (GO:0050855)2.98147622
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92961779
31positive thymic T cell selection (GO:0045059)2.90837391
32dendritic cell chemotaxis (GO:0002407)2.88192583
33positive regulation of interleukin-1 beta secretion (GO:0050718)2.84540908
34regulation of posttranscriptional gene silencing (GO:0060147)2.83568023
35regulation of gene silencing by miRNA (GO:0060964)2.83568023
36regulation of gene silencing by RNA (GO:0060966)2.83568023
37regulation of T cell tolerance induction (GO:0002664)2.82927056
38positive regulation of T cell chemotaxis (GO:0010820)2.81739041
39regulation of T cell chemotaxis (GO:0010819)2.81739041
40sprouting angiogenesis (GO:0002040)2.80596345
41regulation of interleukin-1 beta secretion (GO:0050706)2.79364196
42regulation of interleukin-12 biosynthetic process (GO:0045075)2.78560509
43regulation of lymphocyte chemotaxis (GO:1901623)2.78534776
44pre-miRNA processing (GO:0031054)2.77827542
45positive regulation of SMAD protein import into nucleus (GO:0060391)2.77783909
46pericardium development (GO:0060039)2.77666870
47endocardial cushion development (GO:0003197)2.74950944
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73113166
49nuclear pore complex assembly (GO:0051292)2.72438849
50endothelial tube morphogenesis (GO:0061154)2.68940995
51morphogenesis of an endothelium (GO:0003159)2.68940995
52collagen fibril organization (GO:0030199)2.68770844
53apoptotic process involved in morphogenesis (GO:0060561)2.68216011
54regulation of SMAD protein import into nucleus (GO:0060390)2.67916313
55regulation of tolerance induction (GO:0002643)2.66144430
56sequestering of extracellular ligand from receptor (GO:0035581)2.65982811
57membrane raft organization (GO:0031579)2.65745693
58negative thymic T cell selection (GO:0045060)2.64848714
59chondrocyte proliferation (GO:0035988)2.64804032
60negative regulation of interleukin-12 production (GO:0032695)2.64043387
61negative T cell selection (GO:0043383)2.63441464
62cytoplasmic mRNA processing body assembly (GO:0033962)2.62989192
63regulation of alpha-beta T cell proliferation (GO:0046640)2.62898318
64regulation of interleukin-1 secretion (GO:0050704)2.62827799
65positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.62728360
66plasma membrane repair (GO:0001778)2.62226127
67establishment of apical/basal cell polarity (GO:0035089)2.62071679
68positive regulation of interleukin-1 secretion (GO:0050716)2.61175980
69positive regulation of alpha-beta T cell proliferation (GO:0046641)2.61059245
70negative regulation of fatty acid transport (GO:2000192)2.60174038
71thymic T cell selection (GO:0045061)2.59914203
72lymphocyte chemotaxis (GO:0048247)2.58883170
73positive regulation of T cell mediated cytotoxicity (GO:0001916)2.58268346
74leukocyte aggregation (GO:0070486)2.58247388
75cellular response to type I interferon (GO:0071357)2.57190938
76type I interferon signaling pathway (GO:0060337)2.57190938
77pathway-restricted SMAD protein phosphorylation (GO:0060389)2.57157172
78wound healing, spreading of epidermal cells (GO:0035313)2.55924180
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.55726063
80positive regulation of interleukin-1 beta production (GO:0032731)2.55306847
81negative regulation of T-helper cell differentiation (GO:0045623)2.55121694
82negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55121694
83substrate adhesion-dependent cell spreading (GO:0034446)2.54468207
84regulation of B cell differentiation (GO:0045577)2.53715542
85positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.53016016
86adherens junction assembly (GO:0034333)2.53001833
87regulation of T-helper 1 type immune response (GO:0002825)2.52962590
88protein heterotrimerization (GO:0070208)2.51937796
89response to type I interferon (GO:0034340)2.51812655
90cardiac myofibril assembly (GO:0055003)2.50989761
91negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.50955205
92paraxial mesoderm development (GO:0048339)2.50500343
93regulation of integrin activation (GO:0033623)2.50360990
94regulation of T cell mediated cytotoxicity (GO:0001914)2.49823923
95negative regulation of nitric-oxide synthase activity (GO:0051001)2.47345220
96trophectodermal cell differentiation (GO:0001829)2.46932315
97retina vasculature morphogenesis in camera-type eye (GO:0061299)2.46162095
98positive regulation of type 2 immune response (GO:0002830)2.45926441
99atrioventricular valve morphogenesis (GO:0003181)2.45816456
100regulation of regulatory T cell differentiation (GO:0045589)2.45096883
101stress fiber assembly (GO:0043149)2.44987383
102cellular extravasation (GO:0045123)2.44310863
103sarcomere organization (GO:0045214)2.43507303
104protein localization to endosome (GO:0036010)2.43017792
105negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.42319827
106T cell costimulation (GO:0031295)2.42291128
107epithelial cell-cell adhesion (GO:0090136)2.41979731
108regulation of macrophage cytokine production (GO:0010935)2.41049885
109Arp2/3 complex-mediated actin nucleation (GO:0034314)2.40443009
110T cell selection (GO:0045058)2.40400905
111heterochromatin organization (GO:0070828)2.40074670
112cell adhesion mediated by integrin (GO:0033627)2.40039382
113regulation of antigen processing and presentation (GO:0002577)2.38941312
114establishment of monopolar cell polarity (GO:0061162)2.38502369
115establishment or maintenance of monopolar cell polarity (GO:0061339)2.38502369
116lymphocyte costimulation (GO:0031294)2.38283898
117positive regulation of T-helper 1 type immune response (GO:0002827)2.38071107
118antigen processing and presentation via MHC class Ib (GO:0002475)2.37991350
119NIK/NF-kappaB signaling (GO:0038061)2.37853101
120regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.37594692
121regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.36482530
122regulation of natural killer cell mediated immunity (GO:0002715)2.36482530
123negative regulation of T cell apoptotic process (GO:0070233)2.35865526
124pore complex assembly (GO:0046931)2.35266411
125positive regulation of interleukin-1 production (GO:0032732)2.35171166
126regulation of hippo signaling (GO:0035330)2.34626323
127positive regulation of macrophage differentiation (GO:0045651)2.34334983
128regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.32166438
129positive regulation of gamma-delta T cell activation (GO:0046645)2.31530260
130nuclear pore organization (GO:0006999)2.30878584
131positive regulation of natural killer cell differentiation (GO:0032825)2.29919575
132modulation by symbiont of host defense response (GO:0052031)2.29561823
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.29561823
134modulation by symbiont of host immune response (GO:0052553)2.29561823
135negative regulation of adherens junction organization (GO:1903392)2.27924731
136negative regulation of focal adhesion assembly (GO:0051895)2.27924731
137negative regulation of cell junction assembly (GO:1901889)2.27924731
138skin morphogenesis (GO:0043589)2.26995131
139craniofacial suture morphogenesis (GO:0097094)2.26634432
140positive T cell selection (GO:0043368)2.25568950
141response to laminar fluid shear stress (GO:0034616)2.25460034
142cell-substrate junction assembly (GO:0007044)2.24945552
143vascular endothelial growth factor signaling pathway (GO:0038084)2.23740838
144NLS-bearing protein import into nucleus (GO:0006607)2.23399365
145tyrosine phosphorylation of STAT protein (GO:0007260)2.22888626
146regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.22848901
147substrate-dependent cell migration (GO:0006929)2.22841176
148regulation of RNA export from nucleus (GO:0046831)2.22473187
149mesodermal cell differentiation (GO:0048333)2.20022035
150anterior/posterior axis specification, embryo (GO:0008595)2.19466249
151heterotypic cell-cell adhesion (GO:0034113)2.19192969
152establishment of endothelial barrier (GO:0061028)2.18896728
153tolerance induction (GO:0002507)2.17688892
154positive regulation of blood vessel endothelial cell migration (GO:0043536)2.17648219
155cranial suture morphogenesis (GO:0060363)2.17163565
156extracellular matrix assembly (GO:0085029)2.16353807
157regulation of transforming growth factor beta2 production (GO:0032909)2.16182099
158heart morphogenesis (GO:0003007)2.16019764
159cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.15960492
160negative regulation of anoikis (GO:2000811)2.15686391
161embryonic placenta development (GO:0001892)2.14976631
162positive regulation of Rho protein signal transduction (GO:0035025)2.14780503
163negative regulation of B cell proliferation (GO:0030889)2.14564039
164embryonic process involved in female pregnancy (GO:0060136)2.13960225
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.13311617
166trabecula morphogenesis (GO:0061383)2.13023844
167adherens junction organization (GO:0034332)2.12578181
168regulation of translational fidelity (GO:0006450)2.12078516
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.11151627
170epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.10840284
171regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.10343070
172positive regulation of tolerance induction (GO:0002645)2.10325089
173wound healing, spreading of cells (GO:0044319)2.09635989
174regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.08442010
175response to interleukin-15 (GO:0070672)2.08352658
176branching involved in salivary gland morphogenesis (GO:0060445)2.08069584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.49017192
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.42045292
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45683692
4E2F7_22180533_ChIP-Seq_HELA_Human3.26328814
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.20672655
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.20388819
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16779898
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.95369150
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79277357
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63948143
11* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.63405647
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.58042219
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54253569
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.50314636
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.48796247
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.48055622
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.48055622
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.48055622
19MYC_22102868_ChIP-Seq_BL_Human2.47010080
20* IRF8_27001747_Chip-Seq_BMDM_Mouse2.46586349
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.45256585
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39102674
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.34134735
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.27308331
25* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21864341
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20730833
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12835489
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08801268
29* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.08786979
30* ELK3_25401928_ChIP-Seq_HUVEC_Human2.05923365
31KDM2B_26808549_Chip-Seq_DND41_Human2.04324420
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.03271801
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02591289
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96775707
35* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.90715385
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.88559771
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88466641
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.87160549
39VDR_21846776_ChIP-Seq_THP-1_Human1.84522193
40* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.82932604
41* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81441393
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73979337
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73941011
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71714505
45* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.69890774
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69221965
47* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68812828
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67790632
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66566830
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65412631
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64787145
52RUNX_20019798_ChIP-Seq_JUKART_Human1.64560867
53* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62986481
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.61565863
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59472915
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.56899832
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56406402
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.54081445
59MAF_26560356_Chip-Seq_TH1_Human1.53989754
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53837207
61SPI1_23547873_ChIP-Seq_NB4_Human1.53702475
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53046425
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51585259
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45496841
65* VDR_24787735_ChIP-Seq_THP-1_Human1.44480841
66TCF7_22412390_ChIP-Seq_EML_Mouse1.43821740
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43290052
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41829969
69GATA3_27048872_Chip-Seq_THYMUS_Human1.40455434
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.39640854
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39333821
72BRD4_25478319_ChIP-Seq_HGPS_Human1.39231536
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38595090
74* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38515677
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36646151
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36026897
77UTX_26944678_Chip-Seq_JUKART_Human1.35123471
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33784908
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33509201
80KDM2B_26808549_Chip-Seq_K562_Human1.31955561
81MYB_26560356_Chip-Seq_TH2_Human1.30428089
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.28409465
83* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.27781194
84* FOXO3_23340844_ChIP-Seq_DLD1_Human1.26640641
85* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25276288
86GATA3_26560356_Chip-Seq_TH2_Human1.24781130
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24731349
88* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24132386
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.23800891
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21873827
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21050148
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20801079
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19783341
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19184178
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18979138
96* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18332709
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.16964310
98* TP53_22127205_ChIP-Seq_IMR90_Human1.16633863
99MYB_26560356_Chip-Seq_TH1_Human1.16511303
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15688673
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15059604
102ISL1_27105846_Chip-Seq_CPCs_Mouse1.14846667
103* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14844988
104TP53_18474530_ChIP-ChIP_U2OS_Human1.14504491
105* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13468666
106RACK7_27058665_Chip-Seq_MCF-7_Human1.13120238
107* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13019845
108* TBX20_22080862_ChIP-Seq_HEART_Mouse1.12854915
109* TBX20_22328084_ChIP-Seq_HEART_Mouse1.12854915
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.12832932
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12475565
112SPI1_23127762_ChIP-Seq_K562_Human1.12299969
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12149760
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11798536
115PU_27001747_Chip-Seq_BMDM_Mouse1.11686981
116* EP300_21415370_ChIP-Seq_HL-1_Mouse1.11636827
117* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11046524
118* SMAD_19615063_ChIP-ChIP_OVARY_Human1.10003125
119* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08999169
120KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08304838
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07834232
122PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04687740
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04037433
124SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03288662
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03237191
126* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01810530
127* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01810530
128* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01068474
129* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00222835
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99911924
131* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99717796
132* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99660799
133* VDR_24763502_ChIP-Seq_THP-1_Human0.98702209
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98562728
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98562728
136NCOR1_26117541_ChIP-Seq_K562_Human0.98190083
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.98154025
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97653152
139TP53_16413492_ChIP-PET_HCT116_Human0.96561586
140* CJUN_26792858_Chip-Seq_BT549_Human0.96167644
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95191712
142MAF_26560356_Chip-Seq_TH2_Human0.94241136
143* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93829531
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92902685
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91951403
146ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91845239
147JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91186716
148ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91122428
149CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89617998
150E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85959785
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.84599947
152* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83979006
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82549467
154PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80923786
155EOMES_21245162_ChIP-Seq_HESCs_Human0.80812419
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.80638119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.19842325
2MP0005623_abnormal_meninges_morphology3.29971420
3MP0010352_gastrointestinal_tract_polyps2.95219812
4MP0003436_decreased_susceptibility_to2.72412149
5MP0003566_abnormal_cell_adhesion2.70812033
6MP0003705_abnormal_hypodermis_morpholog2.63553091
7MP0001835_abnormal_antigen_presentation2.57567776
8MP0005671_abnormal_response_to2.54746491
9* MP0003279_aneurysm2.29714609
10MP0005503_abnormal_tendon_morphology2.27682827
11MP0005275_abnormal_skin_tensile2.27033942
12MP0004272_abnormal_basement_membrane2.19342295
13MP0009785_altered_susceptibility_to2.18158933
14MP0003724_increased_susceptibility_to2.12720995
15MP0005000_abnormal_immune_tolerance2.12412967
16MP0004084_abnormal_cardiac_muscle2.02250404
17MP0002148_abnormal_hypersensitivity_rea1.96852236
18MP0001348_abnormal_lacrimal_gland1.94771654
19MP0001958_emphysema1.91303651
20MP0006054_spinal_hemorrhage1.89623707
21MP0003091_abnormal_cell_migration1.87279094
22MP0005023_abnormal_wound_healing1.84382589
23MP0006082_CNS_inflammation1.81913042
24MP0005076_abnormal_cell_differentiation1.80602567
25MP0000733_abnormal_muscle_development1.77474625
26MP0003950_abnormal_plasma_membrane1.76232761
27MP0003300_gastrointestinal_ulcer1.75554987
28MP0002723_abnormal_immune_serum1.68038554
29MP0002452_abnormal_antigen_presenting1.64251880
30MP0001533_abnormal_skeleton_physiology1.64238628
31MP0002420_abnormal_adaptive_immunity1.63402046
32MP0001819_abnormal_immune_cell1.62283391
33MP0002419_abnormal_innate_immunity1.58800984
34MP0001542_abnormal_bone_strength1.57962220
35MP0003567_abnormal_fetal_cardiomyocyte1.52034670
36MP0005025_abnormal_response_to1.49690660
37MP0009333_abnormal_splenocyte_physiolog1.48751937
38MP0002254_reproductive_system_inflammat1.47605006
39MP0000685_abnormal_immune_system1.44552209
40* MP0002925_abnormal_cardiovascular_devel1.44008289
41MP0003385_abnormal_body_wall1.43926476
42MP0005257_abnormal_intraocular_pressure1.40840589
43MP0008775_abnormal_heart_ventricle1.34336703
44MP0010630_abnormal_cardiac_muscle1.33623688
45MP0008057_abnormal_DNA_replication1.30488241
46MP0004197_abnormal_fetal_growth/weight/1.30450321
47MP0010155_abnormal_intestine_physiology1.30356757
48MP0003122_maternal_imprinting1.30349528
49MP0005508_abnormal_skeleton_morphology1.30015490
50MP0003828_pulmonary_edema1.28599121
51MP0004510_myositis1.27567189
52MP0003984_embryonic_growth_retardation1.26825096
53MP0002086_abnormal_extraembryonic_tissu1.26528991
54MP0010030_abnormal_orbit_morphology1.26354808
55MP0002398_abnormal_bone_marrow1.26215472
56MP0003448_altered_tumor_morphology1.26206631
57MP0002088_abnormal_embryonic_growth/wei1.25077104
58* MP0000767_abnormal_smooth_muscle1.24208142
59MP0003045_fibrosis1.23733574
60MP0005380_embryogenesis_phenotype1.23517203
61MP0001672_abnormal_embryogenesis/_devel1.23517203
62MP0000716_abnormal_immune_system1.23306048
63MP0004947_skin_inflammation1.20940027
64MP0003191_abnormal_cellular_cholesterol1.20575345
65MP0002933_joint_inflammation1.18348394
66MP0010368_abnormal_lymphatic_system1.18345934
67MP0004233_abnormal_muscle_weight1.16431412
68MP0003935_abnormal_craniofacial_develop1.16352816
69MP0002084_abnormal_developmental_patter1.14964239
70MP0001790_abnormal_immune_system1.14048457
71MP0005387_immune_system_phenotype1.14048457
72MP0001845_abnormal_inflammatory_respons1.12435364
73MP0003121_genomic_imprinting1.12309975
74MP0002932_abnormal_joint_morphology1.11590951
75MP0005390_skeleton_phenotype1.11522089
76MP0009278_abnormal_bone_marrow1.10980321
77MP0002085_abnormal_embryonic_tissue1.10303416
78MP0001853_heart_inflammation1.09583745
79MP0004087_abnormal_muscle_fiber1.06507834
80MP0002168_other_aberrant_phenotype1.06177531
81MP0003890_abnormal_embryonic-extraembry1.05667684
82MP0002127_abnormal_cardiovascular_syste1.05364545
83MP0005164_abnormal_response_to1.04984877
84MP0009384_cardiac_valve_regurgitation1.04407220
85MP0003303_peritoneal_inflammation1.04139716
86MP0003763_abnormal_thymus_physiology1.03636355
87MP0000465_gastrointestinal_hemorrhage1.03172992
88MP0001697_abnormal_embryo_size1.02073975
89MP0002877_abnormal_melanocyte_morpholog1.01990432
90MP0006138_congestive_heart_failure1.00876832
91MP0002429_abnormal_blood_cell0.98863912
92MP0002722_abnormal_immune_system0.98168727
93* MP0000266_abnormal_heart_morphology0.96872467
94MP0000428_abnormal_craniofacial_morphol0.96327991
95MP0003115_abnormal_respiratory_system0.96265913
96MP0000432_abnormal_head_morphology0.95979999
97* MP0001614_abnormal_blood_vessel0.95841575
98* MP0002128_abnormal_blood_circulation0.95833856
99MP0000689_abnormal_spleen_morphology0.94019796
100MP0001730_embryonic_growth_arrest0.93301237
101MP0002006_tumorigenesis0.93269411
102MP0002396_abnormal_hematopoietic_system0.93062092
103MP0001800_abnormal_humoral_immune0.92581035
104MP0000751_myopathy0.92305514
105MP0001293_anophthalmia0.92215050
106MP0004036_abnormal_muscle_relaxation0.91847469
107MP0002998_abnormal_bone_remodeling0.91551599
108MP0005464_abnormal_platelet_physiology0.90627967
109MP0004883_abnormal_blood_vessel0.90498458
110MP0003755_abnormal_palate_morphology0.90271203
111MP0005330_cardiomyopathy0.89893404
112MP0000350_abnormal_cell_proliferation0.89883160
113MP0001243_abnormal_dermal_layer0.89865723
114MP0001915_intracranial_hemorrhage0.88836631
115MP0003942_abnormal_urinary_system0.88413324
116MP0009250_abnormal_appendicular_skeleto0.88330262
117MP0008260_abnormal_autophagy0.88185605
118MP0002405_respiratory_system_inflammati0.87820764
119MP0005595_abnormal_vascular_smooth0.87561059
120MP0000750_abnormal_muscle_regeneration0.87018796
121MP0000703_abnormal_thymus_morphology0.86601964
122MP0002295_abnormal_pulmonary_circulatio0.86253119
123MP0002138_abnormal_hepatobiliary_system0.85684336
124MP0001849_ear_inflammation0.85123461
125MP0002837_dystrophic_cardiac_calcinosis0.84962596
126MP0000749_muscle_degeneration0.84532528
127MP0005165_increased_susceptibility_to0.84371212
128MP0000003_abnormal_adipose_tissue0.83694484
129MP0001175_abnormal_lung_morphology0.83662051
130MP0002332_abnormal_exercise_endurance0.83514115
131MP0004134_abnormal_chest_morphology0.83424312
132MP0004957_abnormal_blastocyst_morpholog0.82917404
133MP0002060_abnormal_skin_morphology0.82476948
134MP0008004_abnormal_stomach_pH0.82360931
135MP0002108_abnormal_muscle_morphology0.82219944
136MP0003453_abnormal_keratinocyte_physiol0.82080749
137MP0003119_abnormal_digestive_system0.81757313
138MP0001879_abnormal_lymphatic_vessel0.81405954
139MP0003937_abnormal_limbs/digits/tail_de0.80594216
140MP0001544_abnormal_cardiovascular_syste0.80551678
141MP0005385_cardiovascular_system_phenoty0.80551678
142MP0004858_abnormal_nervous_system0.80374734
143MP0009764_decreased_sensitivity_to0.80115281
144MP0005166_decreased_susceptibility_to0.78917358
145MP0000858_altered_metastatic_potential0.78773500
146MP0000534_abnormal_ureter_morphology0.78386449
147MP0001873_stomach_inflammation0.78005076
148MP0008469_abnormal_protein_level0.77987687
149MP0003866_abnormal_defecation0.77481444
150MP0002697_abnormal_eye_size0.77088343
151* MP0000759_abnormal_skeletal_muscle0.76944474
152MP0000249_abnormal_blood_vessel0.76659826
153* MP0001784_abnormal_fluid_regulation0.75030720
154MP0005310_abnormal_salivary_gland0.74658026
155MP0002106_abnormal_muscle_physiology0.74519305
156MP0002972_abnormal_cardiac_muscle0.74188935
157MP0003795_abnormal_bone_structure0.73404646
158MP0002166_altered_tumor_susceptibility0.72190851
159MP0009053_abnormal_anal_canal0.72018950

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.62500212
2Protrusio acetabuli (HP:0003179)4.43162169
3Arterial tortuosity (HP:0005116)3.98558965
4Vascular tortuosity (HP:0004948)3.88539105
5T lymphocytopenia (HP:0005403)3.41332643
6Shallow orbits (HP:0000586)3.39722817
7Cerebral aneurysm (HP:0004944)3.36873353
8Abnormality of T cell number (HP:0011839)3.32927430
9Aortic dissection (HP:0002647)3.26493085
10Ulnar bowing (HP:0003031)3.18666348
11Popliteal pterygium (HP:0009756)3.04296630
12Abnormality of placental membranes (HP:0011409)2.98857858
13Amniotic constriction ring (HP:0009775)2.98857858
14Type 2 muscle fiber atrophy (HP:0003554)2.82412638
15Gastrointestinal infarctions (HP:0005244)2.66552501
16Broad metatarsal (HP:0001783)2.63918418
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.59191623
18Hyporeflexia of lower limbs (HP:0002600)2.57844300
19Aortic aneurysm (HP:0004942)2.56673378
20Persistence of primary teeth (HP:0006335)2.56045573
21Short 4th metacarpal (HP:0010044)2.54129820
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54129820
23Wrist flexion contracture (HP:0001239)2.53805392
24Myositis (HP:0100614)2.53285611
25Ankle contracture (HP:0006466)2.53235698
26Dilatation of the ascending aorta (HP:0005111)2.52219172
27Stomatitis (HP:0010280)2.51082857
28Peritonitis (HP:0002586)2.49611806
29Muscle fiber atrophy (HP:0100295)2.47233728
30Abnormality of the umbilical cord (HP:0010881)2.44313348
31Orchitis (HP:0100796)2.43670338
32Increased connective tissue (HP:0009025)2.40234387
33Genu recurvatum (HP:0002816)2.39051781
34Mitral valve prolapse (HP:0001634)2.38495968
35Wormian bones (HP:0002645)2.32926874
36Bladder diverticulum (HP:0000015)2.26169338
37Muscle fiber splitting (HP:0003555)2.25547691
38Pulmonary infiltrates (HP:0002113)2.25316069
39Absent frontal sinuses (HP:0002688)2.24813574
40Abnormality of oral frenula (HP:0000190)2.24232255
41Abnormal umbilical cord blood vessels (HP:0011403)2.23584641
42Single umbilical artery (HP:0001195)2.23584641
43Abnormality of the fetal cardiovascular system (HP:0010948)2.23584641
44Abnormality of T cells (HP:0002843)2.23578821
45Chest pain (HP:0100749)2.22738291
46Camptodactyly of toe (HP:0001836)2.22235722
47Chronic mucocutaneous candidiasis (HP:0002728)2.22193359
48Recurrent cutaneous fungal infections (HP:0011370)2.22193359
49Optic neuritis (HP:0100653)2.21730166
50Retrobulbar optic neuritis (HP:0100654)2.21730166
51Easy fatigability (HP:0003388)2.21230813
52Reduced subcutaneous adipose tissue (HP:0003758)2.20039527
53Spondylolisthesis (HP:0003302)2.19064506
54Abnormality of macrophages (HP:0004311)2.17657948
55Recurrent fungal infections (HP:0002841)2.17285334
56Rib fusion (HP:0000902)2.14390459
57Abnormality of the neuromuscular junction (HP:0003398)2.13438751
58Fatigable weakness (HP:0003473)2.13438751
59Vertebral arch anomaly (HP:0008438)2.12252044
60Blue sclerae (HP:0000592)2.12098373
61Thin ribs (HP:0000883)2.09305644
62Eczematoid dermatitis (HP:0000976)2.08529661
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.07911213
64Osteolytic defects of the hand bones (HP:0009699)2.07911213
65Syringomyelia (HP:0003396)2.06989274
66Spinal cord lesions (HP:0100561)2.06989274
67Elevated erythrocyte sedimentation rate (HP:0003565)2.06860090
68Autoimmune hemolytic anemia (HP:0001890)2.04751528
69Recurrent abscess formation (HP:0002722)2.03797202
70Abnormalities of placenta or umbilical cord (HP:0001194)2.03629335
71Deviation of the thumb (HP:0009603)2.03268940
72Aplasia of the musculature (HP:0100854)2.01485304
73Recurrent viral infections (HP:0004429)2.00600506
74Atrophic scars (HP:0001075)1.98418486
75Long eyelashes (HP:0000527)1.98376344
76Slender build (HP:0001533)1.97704182
77Vasculitis (HP:0002633)1.97311262
78Trigonocephaly (HP:0000243)1.96348758
79Increased IgM level (HP:0003496)1.94870798
80Abnormal platelet volume (HP:0011876)1.93735282
81Spinal rigidity (HP:0003306)1.92948980
82IgG deficiency (HP:0004315)1.92406568
83Abnormality of the 4th metacarpal (HP:0010012)1.92278742
84Bowed forearm bones (HP:0003956)1.91183994
85Bowing of the arm (HP:0006488)1.91183994
86Hemoptysis (HP:0002105)1.89457762
87Round ear (HP:0100830)1.88160424
88Fused cervical vertebrae (HP:0002949)1.87532896
89Soft skin (HP:0000977)1.85905126
90Right ventricular cardiomyopathy (HP:0011663)1.85767411
91Cervical subluxation (HP:0003308)1.85427971
92Scapular winging (HP:0003691)1.84956250
93Type 1 muscle fiber predominance (HP:0003803)1.84328062
94Abnormality of the peritoneum (HP:0002585)1.83902440
95Joint contractures involving the joints of the feet (HP:0100492)1.82549554
96Flexion contracture of toe (HP:0005830)1.82549554
97Bowel diverticulosis (HP:0005222)1.81914117
98Short middle phalanx of the 5th finger (HP:0004220)1.81787760
99Meningitis (HP:0001287)1.80372243
100Mildly elevated creatine phosphokinase (HP:0008180)1.79943671
101IgA deficiency (HP:0002720)1.79611883
102Short humerus (HP:0005792)1.79556046
103Pustule (HP:0200039)1.78805281
104Proximal placement of thumb (HP:0009623)1.78535906
105Disproportionate tall stature (HP:0001519)1.77992474
106Recurrent bacterial skin infections (HP:0005406)1.77481107
107Chronic diarrhea (HP:0002028)1.77414000
108Increased mean platelet volume (HP:0011877)1.77402555
109Bilateral sensorineural hearing impairment (HP:0008619)1.77380350
110Increased variability in muscle fiber diameter (HP:0003557)1.76677612
111Asymmetry of the thorax (HP:0001555)1.76524205
112Ectopia lentis (HP:0001083)1.76462063
113Limited elbow extension (HP:0001377)1.76296608
114Mitral regurgitation (HP:0001653)1.76148975
115Leukocytosis (HP:0001974)1.76000728
116Spontaneous hematomas (HP:0007420)1.75854890
117Hematochezia (HP:0002573)1.74416726
118Ventricular tachycardia (HP:0004756)1.74338202
119Difficulty running (HP:0009046)1.74200038
120Abnormality of dentin (HP:0010299)1.73675855
121Follicular hyperkeratosis (HP:0007502)1.73641461
122Weak cry (HP:0001612)1.73336939
123Supernumerary ribs (HP:0005815)1.73255380
124Aortic regurgitation (HP:0001659)1.72672765
125Gowers sign (HP:0003391)1.72392853
126Myocardial infarction (HP:0001658)1.71451284
127Abnormality of the tricuspid valve (HP:0001702)1.70821136
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.70235800
129Alopecia of scalp (HP:0002293)1.70023519
130Amaurosis fugax (HP:0100576)1.69367258
131Vertebral clefting (HP:0008428)1.69188971
132Distal lower limb amyotrophy (HP:0008944)1.67826376
133Dislocated radial head (HP:0003083)1.67155464
134Fragile skin (HP:0001030)1.67111005
135Selective tooth agenesis (HP:0001592)1.66760096
136Delayed closure of the anterior fontanelle (HP:0001476)1.66644690
137Broad palm (HP:0001169)1.64583600
138Increased density of long bones (HP:0006392)1.64366646
139Wide anterior fontanel (HP:0000260)1.64186968
140Coronal craniosynostosis (HP:0004440)1.64147553
141Renal duplication (HP:0000075)1.63875395
142Aneurysm (HP:0002617)1.63008795
143Aplasia/hypoplasia of the humerus (HP:0006507)1.61983676
144Vertebral fusion (HP:0002948)1.60738148
145Broad thumb (HP:0011304)1.60671532
146Sudden death (HP:0001699)1.59999967
147Hip contracture (HP:0003273)1.58193304
148Limited hip movement (HP:0008800)1.57928231
149Abnormality of skeletal muscle fiber size (HP:0012084)1.57681964
150Preaxial foot polydactyly (HP:0001841)1.56972850
151Mesomelia (HP:0003027)1.54769230
152Abnormality of the radial head (HP:0003995)1.54454205
153Joint laxity (HP:0001388)1.53105929
154Abnormal vertebral ossification (HP:0100569)1.52235191
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.52225493
156Inguinal hernia (HP:0000023)1.50855462
157Skull defect (HP:0001362)1.50745680
158Tibial bowing (HP:0002982)1.50543911
159Elbow flexion contracture (HP:0002987)1.49517977
160Hyperextensible skin (HP:0000974)1.48806250
161Abnormality of the calcaneus (HP:0008364)1.47347848
162Supernumerary bones of the axial skeleton (HP:0009144)1.47063255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.22007390
2MAP3K103.24564321
3TTN3.08565905
4STK102.45038330
5EPHB12.40107171
6DMPK2.36054211
7TYK22.29207736
8LATS22.24672866
9PDGFRA2.13714062
10DDR21.99740427
11MAP3K141.98648019
12MUSK1.97075903
13MAP4K11.95459030
14TRIB31.93267028
15PIK3CG1.90402135
16ERBB41.87927467
17LATS11.81827747
18EIF2AK31.69871146
19TYRO31.67079666
20ACVR1B1.65265149
21ICK1.63997356
22MOS1.60375689
23CSK1.56119218
24GRK71.55215189
25MAP3K121.54159171
26LRRK21.44264375
27WNK11.43375467
28IRAK41.42078313
29BLK1.40116316
30BMX1.39062095
31FGR1.38539961
32IRAK31.34337999
33MTOR1.33084501
34TRPM71.32105473
35ITK1.31892821
36TXK1.31838076
37MAP3K131.31242892
38TESK21.28814131
39SIK21.28531559
40MARK31.27841553
41RIPK41.25765030
42CDC42BPA1.25024945
43PAK21.24745609
44IKBKE1.24311536
45FES1.24135848
46LIMK11.23247405
47JAK31.22292216
48ALK1.22035088
49GRK61.20880079
50TIE11.20226321
51SIK11.20149380
52MAP3K31.15901447
53PDGFRB1.12726883
54PAK41.12609485
55PTK21.11335710
56FLT31.10617833
57SIK31.06747239
58NEK91.06234857
59PKN21.06121379
60MAP2K31.05483318
61FGFR11.03795818
62TBK11.03516472
63FGFR41.03229889
64EPHA31.02389796
65SMG11.01662429
66MARK21.00603302
67ZAP701.00517831
68MST40.99342082
69FGFR30.98891728
70ROCK20.96265386
71TGFBR20.95904929
72STK240.95862533
73FGFR20.95795918
74EPHA20.94958157
75PRKD10.93997160
76PAK30.92099846
77ILK0.91467976
78BTK0.90194994
79CLK10.88855617
80SYK0.88470351
81STK30.88102112
82CSF1R0.87532063
83INSR0.87074393
84PRPF4B0.86195610
85PIK3CA0.85320217
86BRD40.84231937
87EPHB20.83027894
88ERN10.81342919
89HCK0.80259743
90MAP3K80.80194562
91MET0.79527447
92EEF2K0.78110304
93PTK2B0.76488208
94CDK60.75090481
95MELK0.74217822
96IKBKB0.72920165
97STK40.69922244
98PTK60.69037535
99LYN0.69019119
100PRKD20.68090602
101KIT0.67969403
102PRKCQ0.67855227
103NEK20.67658067
104NTRK10.67432921
105CDK40.67318304
106NUAK10.66359507
107RIPK10.65912438
108PLK20.65414577
109KDR0.63510370
110BMPR1B0.62951102
111MATK0.62916380
112ROCK10.61100630
113PIM10.61056696
114JAK10.58653889
115MAP3K70.58519521
116LCK0.58408147
117CHEK10.57688438
118MAPKAPK20.57008566
119CSNK1D0.56600131
120TEC0.55351638
121ADRBK10.54883865
122EIF2AK10.52390449
123FER0.50989277
124PKN10.50438262
125MAPK10.49490169
126CDK70.48662250
127TAF10.47928006
128CHEK20.47853078
129PAK10.47679936
130MAP3K50.47461057
131CDK80.47163555
132INSRR0.46700279
133STK380.46560574
134TAOK30.46449326
135TESK10.46378883
136ABL10.45299983
137CHUK0.44360154
138FYN0.42720618
139EGFR0.42575164
140CDC70.42270574
141GSK3A0.40899736
142RPS6KB20.39534979
143PRKCH0.39112356
144SRC0.39075137
145NLK0.38626208
146MYLK0.38600593
147CDK90.38576975
148CSNK1A1L0.37745152
149PRKG20.36309266

Predicted pathways (KEGG)

RankGene SetZ-score
1Viral myocarditis_Homo sapiens_hsa054162.21446648
2Adherens junction_Homo sapiens_hsa045202.06948004
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.01030757
4Primary immunodeficiency_Homo sapiens_hsa053401.98895597
5ECM-receptor interaction_Homo sapiens_hsa045121.98891816
6Focal adhesion_Homo sapiens_hsa045101.92118905
7Dilated cardiomyopathy_Homo sapiens_hsa054141.84381643
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.82002547
9MicroRNAs in cancer_Homo sapiens_hsa052061.80290716
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74919686
11Regulation of actin cytoskeleton_Homo sapiens_hsa048101.69598029
12Hippo signaling pathway_Homo sapiens_hsa043901.65305849
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64686729
14Proteoglycans in cancer_Homo sapiens_hsa052051.58816192
15Small cell lung cancer_Homo sapiens_hsa052221.58709108
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.55614164
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51877703
18T cell receptor signaling pathway_Homo sapiens_hsa046601.50001508
19Shigellosis_Homo sapiens_hsa051311.43946255
20Type I diabetes mellitus_Homo sapiens_hsa049401.38142986
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34191185
22Chronic myeloid leukemia_Homo sapiens_hsa052201.33541032
23B cell receptor signaling pathway_Homo sapiens_hsa046621.32251091
24African trypanosomiasis_Homo sapiens_hsa051431.30362722
25Notch signaling pathway_Homo sapiens_hsa043301.30161100
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29366732
27TGF-beta signaling pathway_Homo sapiens_hsa043501.28501023
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26430261
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.25026184
30Renal cell carcinoma_Homo sapiens_hsa052111.24393664
31Influenza A_Homo sapiens_hsa051641.21901578
32Pancreatic cancer_Homo sapiens_hsa052121.19602693
33Rheumatoid arthritis_Homo sapiens_hsa053231.19228857
34HTLV-I infection_Homo sapiens_hsa051661.18936108
35Toxoplasmosis_Homo sapiens_hsa051451.18232041
36Pathways in cancer_Homo sapiens_hsa052001.17562881
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17377178
38Colorectal cancer_Homo sapiens_hsa052101.17233488
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16964845
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16557047
41Tight junction_Homo sapiens_hsa045301.16175948
42Hematopoietic cell lineage_Homo sapiens_hsa046401.15786828
43Rap1 signaling pathway_Homo sapiens_hsa040151.15487490
44p53 signaling pathway_Homo sapiens_hsa041151.14740376
45PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14620197
46Herpes simplex infection_Homo sapiens_hsa051681.14471244
47Basal cell carcinoma_Homo sapiens_hsa052171.14285571
48Tuberculosis_Homo sapiens_hsa051521.13752737
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13690318
50Amoebiasis_Homo sapiens_hsa051461.11276772
51Legionellosis_Homo sapiens_hsa051341.10946234
52Autoimmune thyroid disease_Homo sapiens_hsa053201.10787226
53Axon guidance_Homo sapiens_hsa043601.09972721
54Viral carcinogenesis_Homo sapiens_hsa052031.08537762
55Hedgehog signaling pathway_Homo sapiens_hsa043401.03903063
56Bladder cancer_Homo sapiens_hsa052191.02746401
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.01662307
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00810940
59VEGF signaling pathway_Homo sapiens_hsa043700.99964204
60Allograft rejection_Homo sapiens_hsa053300.99454694
61Osteoclast differentiation_Homo sapiens_hsa043800.97987675
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97449279
63Prostate cancer_Homo sapiens_hsa052150.96118900
64Wnt signaling pathway_Homo sapiens_hsa043100.96020344
65MAPK signaling pathway_Homo sapiens_hsa040100.95602641
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.95472217
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94985945
68Leishmaniasis_Homo sapiens_hsa051400.94646386
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94329664
70Proteasome_Homo sapiens_hsa030500.93956794
71Platelet activation_Homo sapiens_hsa046110.93867997
72mTOR signaling pathway_Homo sapiens_hsa041500.93221836
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92896801
74Apoptosis_Homo sapiens_hsa042100.89580775
75Salmonella infection_Homo sapiens_hsa051320.89506177
76Dorso-ventral axis formation_Homo sapiens_hsa043200.89211569
77Measles_Homo sapiens_hsa051620.88716897
78Chemokine signaling pathway_Homo sapiens_hsa040620.87226005
79Cell cycle_Homo sapiens_hsa041100.87042737
80Antigen processing and presentation_Homo sapiens_hsa046120.86901520
81Pertussis_Homo sapiens_hsa051330.85950918
82Hepatitis B_Homo sapiens_hsa051610.84925307
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83875553
84Melanoma_Homo sapiens_hsa052180.83614561
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83250238
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.82934560
87Endocytosis_Homo sapiens_hsa041440.81363162
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81250671
89ErbB signaling pathway_Homo sapiens_hsa040120.79672386
90Endometrial cancer_Homo sapiens_hsa052130.78321638
91Acute myeloid leukemia_Homo sapiens_hsa052210.77223136
92Graft-versus-host disease_Homo sapiens_hsa053320.76446489
93Ras signaling pathway_Homo sapiens_hsa040140.76039395
94mRNA surveillance pathway_Homo sapiens_hsa030150.73567793
95Non-small cell lung cancer_Homo sapiens_hsa052230.72897093
96Glioma_Homo sapiens_hsa052140.72387160
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71689680
98TNF signaling pathway_Homo sapiens_hsa046680.71252109
99Epstein-Barr virus infection_Homo sapiens_hsa051690.71126816
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71039001
101Malaria_Homo sapiens_hsa051440.70543370
102Phagosome_Homo sapiens_hsa041450.70103552
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69438285
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.65975612
105RNA transport_Homo sapiens_hsa030130.65344136
106Hepatitis C_Homo sapiens_hsa051600.64288868
107HIF-1 signaling pathway_Homo sapiens_hsa040660.63849464
108FoxO signaling pathway_Homo sapiens_hsa040680.63548517
109Staphylococcus aureus infection_Homo sapiens_hsa051500.59364187
110Prolactin signaling pathway_Homo sapiens_hsa049170.58480473
111Estrogen signaling pathway_Homo sapiens_hsa049150.54681838
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54337741
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.53657044
114Lysine degradation_Homo sapiens_hsa003100.52760146
115Protein digestion and absorption_Homo sapiens_hsa049740.52668070
116Choline metabolism in cancer_Homo sapiens_hsa052310.52445062
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52062124
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51976525
119Asthma_Homo sapiens_hsa053100.51910323
120Gap junction_Homo sapiens_hsa045400.51439161
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48764346

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