ADAM1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.91754375
2plasma membrane fusion (GO:0045026)9.31768481
3cell-cell recognition (GO:0009988)9.18840766
4binding of sperm to zona pellucida (GO:0007339)9.15431448
5epithelial cilium movement (GO:0003351)9.13154840
6spermatid development (GO:0007286)8.70976053
7axonemal dynein complex assembly (GO:0070286)8.70436544
8reproduction (GO:0000003)8.60331415
9cilium or flagellum-dependent cell motility (GO:0001539)8.46638738
10motile cilium assembly (GO:0044458)8.32896443
11regulation of cilium movement (GO:0003352)7.75090583
12cilium movement (GO:0003341)7.35048782
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.99825692
14negative regulation of inclusion body assembly (GO:0090084)6.95826707
15sperm capacitation (GO:0048240)6.78171309
16single fertilization (GO:0007338)6.70481300
17piRNA metabolic process (GO:0034587)6.21238467
18male meiosis (GO:0007140)6.02246801
19synaptonemal complex organization (GO:0070193)6.01576138
20calcium ion-dependent exocytosis (GO:0017156)5.99339455
21spermatogenesis (GO:0007283)5.92440194
22male gamete generation (GO:0048232)5.89841158
23synaptonemal complex assembly (GO:0007130)5.78230636
24organic cation transport (GO:0015695)5.73672007
25fertilization (GO:0009566)5.66693961
26microtubule depolymerization (GO:0007019)5.55143750
27gamete generation (GO:0007276)5.44146989
28regulation of inclusion body assembly (GO:0090083)5.40968119
29DNA double-strand break processing (GO:0000729)5.30403839
30spermatid nucleus differentiation (GO:0007289)5.25229064
31ventricular system development (GO:0021591)4.88516386
32cell recognition (GO:0008037)4.87613629
33cellular process involved in reproduction in multicellular organism (GO:0022412)4.87516742
34germ cell development (GO:0007281)4.83020408
35microtubule severing (GO:0051013)4.79669170
36negative regulation of DNA recombination (GO:0045910)4.75946356
37response to pheromone (GO:0019236)4.72877294
38regulation of microtubule-based movement (GO:0060632)4.72863526
39chromatin remodeling at centromere (GO:0031055)4.65710761
40kinetochore assembly (GO:0051382)4.65401289
41DNA damage response, detection of DNA damage (GO:0042769)4.57680637
42CENP-A containing nucleosome assembly (GO:0034080)4.47318483
43somatic hypermutation of immunoglobulin genes (GO:0016446)4.44249276
44somatic diversification of immune receptors via somatic mutation (GO:0002566)4.44249276
45regulation of helicase activity (GO:0051095)4.33726064
46multicellular organismal reproductive process (GO:0048609)4.26527114
47kinetochore organization (GO:0051383)4.18028700
48DNA methylation involved in gamete generation (GO:0043046)4.14389786
49male meiosis I (GO:0007141)4.12952644
50sexual reproduction (GO:0019953)4.00351057
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.92510724
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.92510724
53DNA replication checkpoint (GO:0000076)3.91476742
54protein polyglutamylation (GO:0018095)3.91118961
55glycerol ether metabolic process (GO:0006662)3.91055017
56chromosome condensation (GO:0030261)3.86192177
57single strand break repair (GO:0000012)3.83283156
58seminiferous tubule development (GO:0072520)3.74876355
59chromosome organization involved in meiosis (GO:0070192)3.73987930
60mismatch repair (GO:0006298)3.72144574
61DNA packaging (GO:0006323)3.68010451
62histone exchange (GO:0043486)3.63482352
63protein K11-linked deubiquitination (GO:0035871)3.62950407
64proteasome assembly (GO:0043248)3.62168944
65ether metabolic process (GO:0018904)3.60875567
66left/right pattern formation (GO:0060972)3.56176068
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52272559
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51531007
69histone mRNA metabolic process (GO:0008334)3.49948828
70meiotic nuclear division (GO:0007126)3.44971660
71multicellular organismal development (GO:0007275)3.44360524
72histone H2A acetylation (GO:0043968)3.43819698
73DNA catabolic process, exonucleolytic (GO:0000738)3.43310164
74cullin deneddylation (GO:0010388)3.39919661
75DNA replication-independent nucleosome assembly (GO:0006336)3.37880081
76DNA replication-independent nucleosome organization (GO:0034724)3.37880081
77energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37094308
78ATP synthesis coupled proton transport (GO:0015986)3.37094308
79behavioral response to nicotine (GO:0035095)3.36410071
80microtubule polymerization or depolymerization (GO:0031109)3.34986369
81respiratory chain complex IV assembly (GO:0008535)3.30269368
82urogenital system development (GO:0001655)3.30205271
83DNA replication-dependent nucleosome organization (GO:0034723)3.29421646
84DNA replication-dependent nucleosome assembly (GO:0006335)3.29421646
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.29253306
86establishment of protein localization to mitochondrial membrane (GO:0090151)3.27573260
87meiotic chromosome segregation (GO:0045132)3.26238715
88DNA strand elongation involved in DNA replication (GO:0006271)3.24296560
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24282986
90mitochondrial respiratory chain complex I assembly (GO:0032981)3.24282986
91NADH dehydrogenase complex assembly (GO:0010257)3.24282986
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24157590
93regulation of mitotic spindle checkpoint (GO:1903504)3.24157590
94establishment of integrated proviral latency (GO:0075713)3.23389102
95regulation of feeding behavior (GO:0060259)3.19489830
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19170508
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15989577
98protein deneddylation (GO:0000338)3.13993181
99meiosis I (GO:0007127)3.13199537
100telomere maintenance via semi-conservative replication (GO:0032201)3.12894603
101DNA ligation (GO:0006266)3.12865878
102axon ensheathment in central nervous system (GO:0032291)3.09892629
103central nervous system myelination (GO:0022010)3.09892629
104metaphase plate congression (GO:0051310)3.07140026
105protein complex biogenesis (GO:0070271)3.05626658
106chaperone-mediated protein complex assembly (GO:0051131)3.05157492
107pyrimidine nucleobase catabolic process (GO:0006208)3.05024914
108protein localization to cilium (GO:0061512)3.04927392
109mitochondrial respiratory chain complex assembly (GO:0033108)3.04037005
110DNA strand elongation (GO:0022616)3.03092745
111chaperone-mediated protein transport (GO:0072321)3.02085053
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01585096
113genitalia morphogenesis (GO:0035112)3.00887963
114termination of RNA polymerase II transcription (GO:0006369)2.98269569
115protein K6-linked ubiquitination (GO:0085020)2.97283169
116membrane depolarization during action potential (GO:0086010)2.96425388
117RNA localization (GO:0006403)2.95979513
118amino-acid betaine transport (GO:0015838)2.93806211
119carnitine transport (GO:0015879)2.93806211
120spliceosomal complex assembly (GO:0000245)2.92474035
121negative regulation of DNA-dependent DNA replication (GO:2000104)2.92137021
122polyol catabolic process (GO:0046174)2.90772058
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.90026585
124pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.88848479
125cytochrome complex assembly (GO:0017004)2.88120339
126CTP biosynthetic process (GO:0006241)2.86683791
127CTP metabolic process (GO:0046036)2.86683791
128DNA deamination (GO:0045006)2.85963386
129female gonad development (GO:0008585)2.84606129
130monoubiquitinated protein deubiquitination (GO:0035520)2.82127909
131carnitine transmembrane transport (GO:1902603)2.81248968
132reciprocal meiotic recombination (GO:0007131)2.81123473
133reciprocal DNA recombination (GO:0035825)2.81123473
134alditol metabolic process (GO:0019400)2.78616920
135calcium ion import (GO:0070509)2.77938311
136respiratory electron transport chain (GO:0022904)2.77453247
137microtubule-based movement (GO:0007018)2.77254703
138mitotic recombination (GO:0006312)2.76243924
139somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75593342
140somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75593342
141isotype switching (GO:0045190)2.75593342
142regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75424618
143nucleotide-excision repair, DNA gap filling (GO:0006297)2.74888152
144nucleus organization (GO:0006997)2.74581295
145platelet dense granule organization (GO:0060155)2.73851592
146glycolytic process (GO:0006096)2.73055775
147electron transport chain (GO:0022900)2.72067948
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71313267
149cilium organization (GO:0044782)2.70914066
150lactate metabolic process (GO:0006089)2.70886184
151viral mRNA export from host cell nucleus (GO:0046784)2.70678787
152DNA integration (GO:0015074)2.70494692
153telomere maintenance via recombination (GO:0000722)2.70145827
154RNA destabilization (GO:0050779)2.69070713
155Sertoli cell development (GO:0060009)2.68975977
156GTP biosynthetic process (GO:0006183)2.68870681
157axoneme assembly (GO:0035082)2.67244802
158positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67193899
159negative regulation of organelle assembly (GO:1902116)2.66550376
160cellular component assembly involved in morphogenesis (GO:0010927)2.65281482
161centriole replication (GO:0007099)2.65264435
162postreplication repair (GO:0006301)2.64636483
163protein refolding (GO:0042026)2.63761804
164regulation of spindle checkpoint (GO:0090231)2.63666672
165cilium assembly (GO:0042384)2.62235192
166pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62233988
167cilium morphogenesis (GO:0060271)2.61622179
168negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60939644
169negative regulation of ligase activity (GO:0051352)2.60939644
170deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.60060698
171pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.58790757
172regulation of meiosis I (GO:0060631)2.58131292
173meiotic cell cycle (GO:0051321)2.57225787
174glycerol metabolic process (GO:0006071)2.57201411
175transcription elongation from RNA polymerase III promoter (GO:0006385)2.55305985
176termination of RNA polymerase III transcription (GO:0006386)2.55305985
177protein neddylation (GO:0045116)2.55279672
178phospholipid translocation (GO:0045332)2.53989644
179lipid translocation (GO:0034204)2.53989644
180recombinational repair (GO:0000725)2.53624180
181spliceosomal snRNP assembly (GO:0000387)2.53327677
182telomere maintenance via telomere lengthening (GO:0010833)2.52939109
183iron-sulfur cluster assembly (GO:0016226)2.52716701
184metallo-sulfur cluster assembly (GO:0031163)2.52716701
185chromatin silencing (GO:0006342)2.42730139
186regulation of response to osmotic stress (GO:0047484)2.42264205
187response to acidic pH (GO:0010447)2.41264721
188peptidyl-glutamic acid modification (GO:0018200)2.40260263
189sequestering of actin monomers (GO:0042989)2.39940916
190intraciliary transport (GO:0042073)2.38395395
191mitotic sister chromatid cohesion (GO:0007064)2.36145212
192regulation of cilium assembly (GO:1902017)2.33924187
193regulation of cytokine production involved in inflammatory response (GO:1900015)2.32956824
194sperm motility (GO:0030317)12.4389906
195cell wall macromolecule catabolic process (GO:0016998)12.1265446
196cell wall macromolecule metabolic process (GO:0044036)12.1265446
197fusion of sperm to egg plasma membrane (GO:0007342)12.1060736
198acrosome reaction (GO:0007340)11.5359239
199sperm-egg recognition (GO:0035036)10.2073526
200acrosome assembly (GO:0001675)10.0542043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.53589966
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.33517422
3EZH2_22144423_ChIP-Seq_EOC_Human5.52181146
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55329897
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.93429826
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.68903250
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.57788899
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.38319121
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.26769406
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23724624
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07804564
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91008756
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66843197
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65106902
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53969915
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47633961
17VDR_22108803_ChIP-Seq_LS180_Human2.41426782
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35831854
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.32413889
20VDR_23849224_ChIP-Seq_CD4+_Human2.22254241
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.21152583
22IGF1R_20145208_ChIP-Seq_DFB_Human2.17214326
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17096781
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15314204
25EWS_26573619_Chip-Seq_HEK293_Human2.13900761
26POU5F1_16153702_ChIP-ChIP_HESCs_Human2.12572612
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.11464693
28FOXP3_21729870_ChIP-Seq_TREG_Human2.10169874
29STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09323923
30ELK1_19687146_ChIP-ChIP_HELA_Human2.08493063
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.95171677
32REST_21632747_ChIP-Seq_MESCs_Mouse1.93997085
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.92025022
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91412288
35ZNF274_21170338_ChIP-Seq_K562_Hela1.87197426
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87065710
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.85715809
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77771779
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.73982920
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73759207
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.72662735
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72609722
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.72452575
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72315915
45TAF15_26573619_Chip-Seq_HEK293_Human1.71033514
46MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71029235
47KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.67713974
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.64745632
49ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62267655
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62011927
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60104899
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58865694
53MYC_18940864_ChIP-ChIP_HL60_Human1.58664789
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55899278
55DCP1A_22483619_ChIP-Seq_HELA_Human1.54327758
56KDM2B_26808549_Chip-Seq_REH_Human1.53435544
57GBX2_23144817_ChIP-Seq_PC3_Human1.51046582
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50974646
59P300_19829295_ChIP-Seq_ESCs_Human1.49922992
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46770427
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.45528054
62GABP_19822575_ChIP-Seq_HepG2_Human1.45104219
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43349976
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42280444
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42093366
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41867275
67CBP_20019798_ChIP-Seq_JUKART_Human1.41739943
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41739943
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39972251
70IRF1_19129219_ChIP-ChIP_H3396_Human1.38866154
71GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.37080382
72DROSHA_22980978_ChIP-Seq_HELA_Human1.36162327
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35888234
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35658252
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34625103
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.33840143
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32428502
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31168118
79WDR5_24793694_ChIP-Seq_LNCAP_Human1.30835550
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30565469
81FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30526731
82TTF2_22483619_ChIP-Seq_HELA_Human1.30461117
83STAT1_17558387_ChIP-Seq_HELA_Human1.29609917
84TP53_22573176_ChIP-Seq_HFKS_Human1.29272800
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.24420933
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24341096
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24133980
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23003508
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.22954679
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.22850998
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21772287
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19644039
93XRN2_22483619_ChIP-Seq_HELA_Human1.18757100
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18748546
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18748546
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.18066140
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15781603
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15310711
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14780096
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14159432
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12596627
102TBL1_22424771_ChIP-Seq_293T_Human1.12406423
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.11903452
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.11493292
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11438435
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11117916
107E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11106966
108GF1_26923725_Chip-Seq_HPCs_Mouse1.10486559
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10458012
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.09853510
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08679583
112RNF2_27304074_Chip-Seq_NSC_Mouse1.08447803
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07488404
114SMAD4_21799915_ChIP-Seq_A2780_Human1.07147753
115SOX9_26525672_Chip-Seq_HEART_Mouse1.07066791
116LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06769725
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05507725
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04606157
119TCF4_23295773_ChIP-Seq_U87_Human1.04242150
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04172202
121SOX2_22085726_ChIP-Seq_NPCs_Mouse1.03979897
122REST_18959480_ChIP-ChIP_MESCs_Mouse1.03349525
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.03331180
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.02719711
125P53_22387025_ChIP-Seq_ESCs_Mouse1.02614802
126SMAD3_21741376_ChIP-Seq_ESCs_Human1.02403796
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02267191
128ER_23166858_ChIP-Seq_MCF-7_Human1.00281529
129CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99306690
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99284034
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.99158697
132RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99152798
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.98359123
134BCAT_22108803_ChIP-Seq_LS180_Human0.98059760
135YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97989462
136P300_18555785_Chip-Seq_ESCs_Mouse0.97967380
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97899973
138GATA3_21867929_ChIP-Seq_TH1_Mouse0.97076806
139FUS_26573619_Chip-Seq_HEK293_Human0.96914623
140OCT4_18555785_Chip-Seq_ESCs_Mouse0.96625096
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96476725
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96332568
143NFYB_21822215_ChIP-Seq_K562_Human0.96122526
144P53_21459846_ChIP-Seq_SAOS-2_Human0.95475729
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95004225
146MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94885781
147FOXA1_25329375_ChIP-Seq_VCAP_Human0.94510446
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94510446
149FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93949619
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93810443
151GATA3_21867929_ChIP-Seq_CD8_Mouse0.93799154
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93765005
153GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93115720
154SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92178107
155RARB_27405468_Chip-Seq_BRAIN_Mouse0.92072719
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91366301
157RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91193171
158ETV1_20927104_ChIP-Seq_GIST48_Human0.90814539
159CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90322091
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.89078942
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89068574
162MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89023401
163E2F1_18555785_Chip-Seq_ESCs_Mouse0.88958008
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.88893442
165TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88755805
166SOX2_18555785_Chip-Seq_ESCs_Mouse0.88389619
167PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88199552
168RNF2_27304074_Chip-Seq_ESCs_Mouse0.88036050
169AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87848901
170NANOG_19829295_ChIP-Seq_ESCs_Human0.85097569
171SOX2_19829295_ChIP-Seq_ESCs_Human0.85097569
172ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84817883
173KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84683115
174EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83261457
175CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82829979
176E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79512754
177SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76734789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.21025834
2MP0001929_abnormal_gametogenesis4.54682070
3MP0008057_abnormal_DNA_replication3.34913250
4MP0010094_abnormal_chromosome_stability3.34377531
5MP0008058_abnormal_DNA_repair3.34032019
6MP0008877_abnormal_DNA_methylation3.25051491
7MP0002653_abnormal_ependyma_morphology2.80635538
8* MP0002161_abnormal_fertility/fecundity2.79433724
9MP0002210_abnormal_sex_determination2.67286030
10MP0005084_abnormal_gallbladder_morpholo2.60930127
11MP0005670_abnormal_white_adipose2.36165555
12MP0003693_abnormal_embryo_hatching2.30969224
13MP0001145_abnormal_male_reproductive2.24333479
14MP0006276_abnormal_autonomic_nervous2.19587887
15MP0004270_analgesia2.19428671
16MP0009046_muscle_twitch2.19302050
17MP0008007_abnormal_cellular_replicative2.15425674
18MP0004147_increased_porphyrin_level2.09882128
19* MP0005410_abnormal_fertilization14.0233568
20MP0006292_abnormal_olfactory_placode1.98603228
21MP0000653_abnormal_sex_gland1.96093503
22MP0004957_abnormal_blastocyst_morpholog1.93887113
23MP0003195_calcinosis1.93801684
24MP0004859_abnormal_synaptic_plasticity1.90066385
25MP0005394_taste/olfaction_phenotype1.89020241
26MP0005499_abnormal_olfactory_system1.89020241
27MP0001188_hyperpigmentation1.83312985
28MP0008995_early_reproductive_senescence1.78849658
29MP0003111_abnormal_nucleus_morphology1.75676976
30MP0003806_abnormal_nucleotide_metabolis1.74204351
31MP0001986_abnormal_taste_sensitivity1.73887019
32MP0005423_abnormal_somatic_nervous1.71739061
33MP0003077_abnormal_cell_cycle1.69642729
34MP0004233_abnormal_muscle_weight1.62610832
35MP0005075_abnormal_melanosome_morpholog1.57343666
36MP0003121_genomic_imprinting1.56041438
37MP0003880_abnormal_central_pattern1.52086066
38MP0003635_abnormal_synaptic_transmissio1.51773306
39MP0003567_abnormal_fetal_cardiomyocyte1.48081015
40MP0008875_abnormal_xenobiotic_pharmacok1.44446655
41MP0005623_abnormal_meninges_morphology1.43575895
42MP0002160_abnormal_reproductive_system1.41644937
43MP0002751_abnormal_autonomic_nervous1.40467173
44MP0001486_abnormal_startle_reflex1.37710907
45MP0001984_abnormal_olfaction1.37613397
46MP0000372_irregular_coat_pigmentation1.35856162
47MP0002272_abnormal_nervous_system1.34684017
48MP0009745_abnormal_behavioral_response1.34553711
49MP0000920_abnormal_myelination1.34130325
50MP0003646_muscle_fatigue1.32493686
51MP0002064_seizures1.31860912
52MP0005551_abnormal_eye_electrophysiolog1.29109243
53MP0003329_amyloid_beta_deposits1.27886922
54MP0008789_abnormal_olfactory_epithelium1.25719096
55MP0003122_maternal_imprinting1.23203355
56MP0008004_abnormal_stomach_pH1.22608448
57MP0002095_abnormal_skin_pigmentation1.22119107
58MP0006036_abnormal_mitochondrial_physio1.22040317
59MP0002063_abnormal_learning/memory/cond1.19977814
60MP0008569_lethality_at_weaning1.18901670
61MP0006035_abnormal_mitochondrial_morpho1.18762467
62MP0001968_abnormal_touch/_nociception1.15332936
63MP0002572_abnormal_emotion/affect_behav1.14407607
64MP0003786_premature_aging1.13989334
65MP0003718_maternal_effect1.12234876
66MP0004742_abnormal_vestibular_system1.10772344
67MP0008932_abnormal_embryonic_tissue1.09991119
68MP0000631_abnormal_neuroendocrine_gland1.09238950
69MP0009379_abnormal_foot_pigmentation1.06644526
70MP0002734_abnormal_mechanical_nocicepti1.05776283
71MP0003950_abnormal_plasma_membrane1.05648101
72MP0001440_abnormal_grooming_behavior1.03213790
73MP0001765_abnormal_ion_homeostasis1.02663873
74MP0003186_abnormal_redox_activity1.00018791
75MP0002736_abnormal_nociception_after0.98999951
76MP0003136_yellow_coat_color0.98582068
77MP0008872_abnormal_physiological_respon0.95380234
78MP0000015_abnormal_ear_pigmentation0.93621509
79MP0002229_neurodegeneration0.93480565
80MP0001177_atelectasis0.93262413
81MP0002938_white_spotting0.91617010
82MP0002254_reproductive_system_inflammat0.91565764
83MP0001919_abnormal_reproductive_system0.91253639
84MP0003633_abnormal_nervous_system0.91074350
85MP0003631_nervous_system_phenotype0.89935285
86MP0001119_abnormal_female_reproductive0.88220580
87MP0002067_abnormal_sensory_capabilities0.87409075
88MP0003656_abnormal_erythrocyte_physiolo0.86110860
89MP0004885_abnormal_endolymph0.85369695
90MP0004043_abnormal_pH_regulation0.85129243
91MP0003632_abnormal_nervous_system0.84972004
92MP0000569_abnormal_digit_pigmentation0.83688080
93MP0004811_abnormal_neuron_physiology0.83330491
94MP0002882_abnormal_neuron_morphology0.81988614
95MP0000778_abnormal_nervous_system0.80331223
96MP0001293_anophthalmia0.80014007
97MP0002735_abnormal_chemical_nociception0.78188281
98MP0000516_abnormal_urinary_system0.77729196
99MP0005367_renal/urinary_system_phenotyp0.77729196
100MP0002152_abnormal_brain_morphology0.76834334
101MP0005253_abnormal_eye_physiology0.76565265
102MP0002557_abnormal_social/conspecific_i0.76220765
103MP0008961_abnormal_basal_metabolism0.75639720
104MP0000639_abnormal_adrenal_gland0.75299043
105MP0003890_abnormal_embryonic-extraembry0.74377623
106MP0003941_abnormal_skin_development0.74190065
107MP0002396_abnormal_hematopoietic_system0.73654888
108MP0003634_abnormal_glial_cell0.72529384
109MP0002282_abnormal_trachea_morphology0.72284849
110MP0002102_abnormal_ear_morphology0.71996985
111MP0001502_abnormal_circadian_rhythm0.70750385
112MP0000955_abnormal_spinal_cord0.70460787
113MP0002066_abnormal_motor_capabilities/c0.70395832
114MP0002909_abnormal_adrenal_gland0.69763825
115MP0004145_abnormal_muscle_electrophysio0.69622288
116MP0003690_abnormal_glial_cell0.68966689
117MP0004036_abnormal_muscle_relaxation0.68281357
118MP0004215_abnormal_myocardial_fiber0.68123159
119MP0009697_abnormal_copulation0.67860670
120MP0005377_hearing/vestibular/ear_phenot0.67572508
121MP0003878_abnormal_ear_physiology0.67572508
122MP0005409_darkened_coat_color0.67243744
123MP0000751_myopathy0.66718993
124MP0003787_abnormal_imprinting0.65512388
125MP0005332_abnormal_amino_acid0.65369563
126MP0002822_catalepsy0.65340416
127MP0000647_abnormal_sebaceous_gland0.65146278
128MP0002234_abnormal_pharynx_morphology0.63904663
129MP0001529_abnormal_vocalization0.63538566
130MP0001324_abnormal_eye_pigmentation0.63245866
131MP0005647_abnormal_sex_gland0.62050518
132MP0005389_reproductive_system_phenotype0.61052768
133MP0002752_abnormal_somatic_nervous0.60915647
134MP0006072_abnormal_retinal_apoptosis0.59324740
135MP0004142_abnormal_muscle_tone0.58530534
136MP0005195_abnormal_posterior_eye0.57555550
137MP0001485_abnormal_pinna_reflex0.56565130
138MP0005171_absent_coat_pigmentation0.56445384
139MP0003861_abnormal_nervous_system0.56334714
140MP0000534_abnormal_ureter_morphology0.54836774
141MP0003115_abnormal_respiratory_system0.52928933
142MP0000604_amyloidosis0.52379121
143MP0003879_abnormal_hair_cell0.51120782
144MP0001970_abnormal_pain_threshold0.50613727
145MP0001963_abnormal_hearing_physiology0.49562519
146MP0004085_abnormal_heartbeat0.48417636
147MP0004133_heterotaxia0.47493579
148MP0002928_abnormal_bile_duct0.46989339
149MP0005386_behavior/neurological_phenoty0.46249083
150MP0004924_abnormal_behavior0.46249083
151MP0005174_abnormal_tail_pigmentation0.45670984
152MP0002269_muscular_atrophy0.44734882
153MP0001905_abnormal_dopamine_level0.44637278
154MP0001501_abnormal_sleep_pattern0.44626565
155MP0003045_fibrosis0.44234508
156MP0005666_abnormal_adipose_tissue0.43982799
157MP0002184_abnormal_innervation0.43824151

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.40305121
2Abnormal respiratory motile cilium morphology (HP:0005938)8.40305121
3Abnormal respiratory motile cilium physiology (HP:0012261)8.31773049
4Abnormal ciliary motility (HP:0012262)6.64541901
5Rhinitis (HP:0012384)6.59298359
6Chronic bronchitis (HP:0004469)6.31409277
7Infertility (HP:0000789)6.17427538
8Nasal polyposis (HP:0100582)5.11983644
9Abnormality of the nasal mucosa (HP:0000433)4.08481867
10Male infertility (HP:0003251)4.08376343
11Septo-optic dysplasia (HP:0100842)3.94030476
12Nephronophthisis (HP:0000090)3.90332126
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.78712266
14Bronchitis (HP:0012387)3.75174011
15Acute necrotizing encephalopathy (HP:0006965)3.71518745
16Bronchiectasis (HP:0002110)3.66612856
17Ependymoma (HP:0002888)3.64040699
18Agnosia (HP:0010524)3.63312917
19Acute encephalopathy (HP:0006846)3.53602320
20Intestinal atresia (HP:0011100)3.25675485
21Chromsome breakage (HP:0040012)3.19821411
22Progressive macrocephaly (HP:0004481)3.19392397
23Abnormality of chromosome stability (HP:0003220)3.18415518
24Meckel diverticulum (HP:0002245)3.15947802
253-Methylglutaconic aciduria (HP:0003535)3.15300639
26Abnormal mitochondria in muscle tissue (HP:0008316)3.14829980
27Increased CSF lactate (HP:0002490)3.10243184
28Abnormality of the ileum (HP:0001549)3.09673456
29Abnormal number of erythroid precursors (HP:0012131)3.09074822
30Aplasia/Hypoplasia of the uvula (HP:0010293)3.04699815
31Mitochondrial inheritance (HP:0001427)3.04636747
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93159156
33Colon cancer (HP:0003003)2.92313295
34Abnormality of the renal medulla (HP:0100957)2.91995567
35Abolished electroretinogram (ERG) (HP:0000550)2.91483844
36Medulloblastoma (HP:0002885)2.91312710
37Abnormal rod and cone electroretinograms (HP:0008323)2.89658312
38Growth hormone deficiency (HP:0000824)2.82977112
39Recurrent otitis media (HP:0000403)2.81252875
40Hepatocellular necrosis (HP:0001404)2.76873126
41Methylmalonic acidemia (HP:0002912)2.75400818
42Abnormality of the preputium (HP:0100587)2.72940169
43Attenuation of retinal blood vessels (HP:0007843)2.71873226
44Recurrent sinusitis (HP:0011108)2.70112625
45Pancreatic cysts (HP:0001737)2.69482129
46Abnormal spermatogenesis (HP:0008669)2.66978811
47Cerebral edema (HP:0002181)2.66642235
48Medial flaring of the eyebrow (HP:0010747)2.65840404
49Neurofibrillary tangles (HP:0002185)2.61036142
50Hepatic necrosis (HP:0002605)2.59315048
51Hyperglycinemia (HP:0002154)2.55918574
52Choroideremia (HP:0001139)2.54913852
53Rectovaginal fistula (HP:0000143)2.53433954
54Rectal fistula (HP:0100590)2.53433954
55Rhabdomyosarcoma (HP:0002859)2.53300641
56Abnormality of the labia minora (HP:0012880)2.53072066
57Lipid accumulation in hepatocytes (HP:0006561)2.52985173
58Microvesicular hepatic steatosis (HP:0001414)2.48431791
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.45430212
60Molar tooth sign on MRI (HP:0002419)2.44945504
61Abnormality of midbrain morphology (HP:0002418)2.44945504
62Increased hepatocellular lipid droplets (HP:0006565)2.41103913
63Tubulointerstitial nephritis (HP:0001970)2.40265550
64Tubular atrophy (HP:0000092)2.39539553
65Abnormality of cells of the erythroid lineage (HP:0012130)2.35749979
66Glioma (HP:0009733)2.35299934
67Optic nerve hypoplasia (HP:0000609)2.32856917
68Small intestinal stenosis (HP:0012848)2.32288416
69Duodenal stenosis (HP:0100867)2.32288416
70Spastic tetraparesis (HP:0001285)2.32053475
71Optic disc pallor (HP:0000543)2.30068923
72Abnormal gallbladder physiology (HP:0012438)2.29735334
73Cholecystitis (HP:0001082)2.29735334
74Clubbing of toes (HP:0100760)2.26915049
75Astrocytoma (HP:0009592)2.24887559
76Abnormality of the astrocytes (HP:0100707)2.24887559
77Vaginal fistula (HP:0004320)2.24668300
78Carpal bone hypoplasia (HP:0001498)2.24353643
79Pancreatic fibrosis (HP:0100732)2.23180332
80Facial diplegia (HP:0001349)2.23086207
81Impulsivity (HP:0100710)2.21179216
82Abnormality of the duodenum (HP:0002246)2.19577096
83Decreased central vision (HP:0007663)2.18773255
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.17612907
85Dyschromatopsia (HP:0007641)2.17600214
86Increased serum lactate (HP:0002151)2.17174995
87Cerebral inclusion bodies (HP:0100314)2.16661803
88Congenital stationary night blindness (HP:0007642)2.16448239
89Abnormality of saccadic eye movements (HP:0000570)2.15961483
90Bony spicule pigmentary retinopathy (HP:0007737)2.15146095
91Constricted visual fields (HP:0001133)2.14627764
92Lactic acidosis (HP:0003128)2.12923085
93Progressive microcephaly (HP:0000253)2.12168359
94Methylmalonic aciduria (HP:0012120)2.10695158
95Absent septum pellucidum (HP:0001331)2.10153287
96Biliary tract neoplasm (HP:0100574)2.09715791
97Tubulointerstitial abnormality (HP:0001969)2.05579824
98Heterotopia (HP:0002282)2.05543237
99Sensory axonal neuropathy (HP:0003390)2.04583940
100Hyperglycinuria (HP:0003108)2.04411097
101Recurrent bronchitis (HP:0002837)2.04350501
102Hemiparesis (HP:0001269)2.03604513
103Triphalangeal thumb (HP:0001199)2.02575452
104True hermaphroditism (HP:0010459)2.02502642
105Progressive cerebellar ataxia (HP:0002073)2.01808768
106Sloping forehead (HP:0000340)2.00287672
107Dynein arm defect of respiratory motile cilia (HP:0012255)12.5385901
108Absent/shortened dynein arms (HP:0200106)12.5385901
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6445195
110Lethargy (HP:0001254)1.99586186
111Abnormality of the septum pellucidum (HP:0007375)1.98726599
112Delayed CNS myelination (HP:0002188)1.95567924
113Intestinal fistula (HP:0100819)1.92628990
114Type I transferrin isoform profile (HP:0003642)1.91860519
115Abnormal drinking behavior (HP:0030082)1.91051955
116Polydipsia (HP:0001959)1.91051955
117Oligodactyly (hands) (HP:0001180)1.89827322
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88761723
119Abnormality of glycine metabolism (HP:0010895)1.87159685
120Abnormality of serine family amino acid metabolism (HP:0010894)1.87159685
121Reduced antithrombin III activity (HP:0001976)1.85979588
122Abnormality of ocular smooth pursuit (HP:0000617)1.85351547
123Gastrointestinal atresia (HP:0002589)1.85094358
124Supranuclear gaze palsy (HP:0000605)1.84311538
125Congenital, generalized hypertrichosis (HP:0004540)1.82257916
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.81213168
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81213168
128Neoplasm of the oral cavity (HP:0100649)1.80124483
129Abnormality of the fovea (HP:0000493)1.79387724
130Gonadotropin excess (HP:0000837)1.78801327
131Respiratory failure (HP:0002878)1.78234697
132Renal Fanconi syndrome (HP:0001994)1.76821963
133Bell-shaped thorax (HP:0001591)1.76237743
134Congenital malformation of the right heart (HP:0011723)1.76066294
135Double outlet right ventricle (HP:0001719)1.76066294
136Exercise intolerance (HP:0003546)1.75080913
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73647607
138Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73647607
139Patellar aplasia (HP:0006443)1.73607573
140Gait imbalance (HP:0002141)1.72147223
141Gaze-evoked nystagmus (HP:0000640)1.71953536
142Stage 5 chronic kidney disease (HP:0003774)1.71686778
143Spastic gait (HP:0002064)1.71111091
144Aplasia/Hypoplasia of the lens (HP:0008063)1.70084180
145Retinal dysplasia (HP:0007973)1.69445283
146Myokymia (HP:0002411)1.68293315
147Abnormality of the lower motor neuron (HP:0002366)1.66388082
148Abnormality of permanent molar morphology (HP:0011071)1.64579018
149Abnormality of the dental root (HP:0006486)1.64579018
150Taurodontia (HP:0000679)1.64579018
151Tubulointerstitial fibrosis (HP:0005576)1.63671257
152Congenital primary aphakia (HP:0007707)1.61850062
153Impaired smooth pursuit (HP:0007772)1.61422023
154Bundle branch block (HP:0011710)1.60399884
155Postural instability (HP:0002172)1.59447946
156Abnormality of renal excretion (HP:0011036)1.59117038
157Peripheral hypomyelination (HP:0007182)1.57037084
158Abnormality of the corticospinal tract (HP:0002492)1.55916323
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.52911989
160Postaxial hand polydactyly (HP:0001162)1.51578872
161Abnormality of the dental pulp (HP:0006479)1.49938032
162Intention tremor (HP:0002080)1.49343566
163Azoospermia (HP:0000027)1.49109806
164Aplasia/Hypoplasia of the brainstem (HP:0007362)1.48245504
165Hypoplasia of the brainstem (HP:0002365)1.48245504
166Abnormality of molar (HP:0011077)1.47850157
167Abnormality of molar morphology (HP:0011070)1.47850157
168Postaxial foot polydactyly (HP:0001830)1.47161688
169Amyotrophic lateral sclerosis (HP:0007354)1.45906002
170Decreased motor nerve conduction velocity (HP:0003431)1.45733144
171Dysdiadochokinesis (HP:0002075)1.45049123
172Chronic hepatic failure (HP:0100626)1.44969333
173Vaginal atresia (HP:0000148)1.44557821
174Exercise-induced myalgia (HP:0003738)1.43736932
175Neuronal loss in central nervous system (HP:0002529)1.41170855
176Oculomotor apraxia (HP:0000657)1.40648026
177Genital tract atresia (HP:0001827)1.40636755
178Truncal ataxia (HP:0002078)1.39789749
179Short ribs (HP:0000773)1.39415932
180Bile duct proliferation (HP:0001408)1.39327551
181Abnormal biliary tract physiology (HP:0012439)1.39327551
182Congenital hepatic fibrosis (HP:0002612)1.39215928
183Poor coordination (HP:0002370)1.38593020
184Nephrogenic diabetes insipidus (HP:0009806)1.37890277
185Truncal obesity (HP:0001956)1.37866669
186Hyporeflexia of lower limbs (HP:0002600)1.36299584
187Abnormal urine output (HP:0012590)1.36289492
188Impaired vibration sensation in the lower limbs (HP:0002166)1.35716135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.18400435
2PDK47.18400435
3PRKD35.38483619
4TESK15.06564498
5CDC74.78317538
6ICK4.60833073
7PDK24.54395029
8MAP4K23.33334314
9STK393.30123093
10NUAK12.70424578
11STK162.63966546
12MKNK12.52907735
13PNCK2.45656277
14VRK22.42872909
15MKNK22.27554731
16PTK2B2.22621581
17PBK2.22486594
18WNK32.18400756
19WNK42.15274662
20STK382.03505709
21SRPK11.97708264
22PLK41.81415574
23BUB11.81327939
24WEE11.79400557
25BCKDK1.78878797
26ACVR1B1.64138993
27WNK11.58473423
28PLK31.53152879
29MAPK131.50340670
30ERBB31.49219463
31CASK1.48113296
32EIF2AK11.44449737
33DYRK21.42261752
34VRK11.38869221
35ZAK1.36028155
36MST41.33226638
37TNIK1.31371680
38BMPR1B1.24016427
39PDK11.23958485
40TRIM281.23399503
41FRK1.22245051
42OXSR11.19666926
43ATR1.18506964
44TYRO31.17850767
45DYRK1B1.16933095
46PLK11.15765345
47ADRBK21.11590333
48PIK3CA1.09203711
49NEK21.08092513
50NTRK21.05592501
51CAMK1G1.02799771
52EIF2AK21.02000391
53CSNK1G21.00030462
54NEK10.99778240
55EIF2AK30.98289661
56MARK20.97790573
57ERBB40.97127578
58MUSK0.95816908
59GRK10.94100286
60PLK20.93143908
61RPS6KA40.84627777
62PDPK10.83259849
63NME10.82653249
64INSRR0.76267206
65DYRK30.75479298
66DAPK10.74163002
67MAPKAPK50.73521809
68TEC0.72490445
69RIPK40.71996058
70SIK20.70569193
71CSNK1G30.70210017
72PIM20.70013242
73MARK10.68726459
74AURKB0.67656903
75LMTK20.65645958
76TSSK60.63973604
77FGFR20.63627706
78EPHA40.63405242
79NEK60.63367171
80ADRBK10.62762239
81TLK10.62483140
82CSNK1G10.62166453
83PKN10.60713129
84PIM10.59932960
85EPHB10.59798641
86PAK60.59074778
87BLK0.58838971
88TAF10.58388702
89PAK30.57513459
90BCR0.57358133
91NTRK30.57296805
92MAP3K40.57250673
93CSNK2A10.56051289
94CAMK40.55129880
95CSNK2A20.53424409
96MATK0.53231879
97PINK10.50943985
98RPS6KA50.50905501
99STK30.49181605
100PRKCG0.49171623
101TESK20.48810863
102DAPK20.47608274
103CDK150.46959782
104IKBKE0.46371052
105CDK50.45586815
106CDK180.43779796
107ITK0.42306233
108KDR0.41446463
109MINK10.39574905
110GRK70.39493173
111IRAK10.39176167
112CDK11A0.38834127
113TNK20.38643056
114PAK40.38633664
115PRKDC0.38592241
116MAP2K70.38591795
117MAPK150.38425078
118CAMK2A0.38062116
119PRKCE0.37991689
120BRSK20.37217781
121IRAK20.36382643
122NME20.35621078
123SGK4940.35193285
124SGK2230.35193285
125CDK140.34590172
126CSNK1A1L0.34509499
127CHEK20.34299405
128MAP3K90.32941766
129CAMKK10.32638273
130RIPK10.32175752
131UHMK10.31666109
132STK110.31000425
133MAP2K60.29697172
134PAK20.28713640
135CLK10.28491058
136CAMK2B0.27643248
137PAK10.27395657
138CHEK10.26289176
139PRKAA10.26116149
140CCNB10.25696963
141PDGFRB0.25529884
142PASK0.25363089
143PRKCQ0.25209833
144CSNK1D0.24127345
145TTK0.22455384
146PRKG10.22219886
147FES0.22091917
148MTOR0.21946785
149PRKCZ0.21094836
150MAPK100.20166071
151GSK3B0.19408436
152RPS6KA30.18999097
153CAMK10.18582785
154SGK10.16853135
155CAMK2D0.16536118
156ATM0.16528215
157EEF2K0.16385411
158PHKG10.16361972
159PHKG20.16361972
160PRKCB0.15692302
161PRKACB0.15303684
162PRKCH0.14151570
163MAPK80.12867912
164YES10.12617816
165CAMK2G0.12114308
166FGR0.11047898
167CSNK1E0.11006822
168PRKACG0.10689565
169SGK30.10481038
170FYN0.10419346
171PRKD10.09620597
172PRKACA0.08912979

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.28871480
2Proteasome_Homo sapiens_hsa030503.41713468
3Fatty acid biosynthesis_Homo sapiens_hsa000613.34063365
4Homologous recombination_Homo sapiens_hsa034403.32661347
5DNA replication_Homo sapiens_hsa030303.28060593
6Non-homologous end-joining_Homo sapiens_hsa034503.03957934
7Fanconi anemia pathway_Homo sapiens_hsa034603.01090707
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.91242927
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.85416104
10Vitamin B6 metabolism_Homo sapiens_hsa007502.82816300
11Oxidative phosphorylation_Homo sapiens_hsa001902.82208230
12Parkinsons disease_Homo sapiens_hsa050122.73360562
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53943226
14Protein export_Homo sapiens_hsa030602.46584749
15RNA polymerase_Homo sapiens_hsa030202.30664561
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.22873574
17Pyruvate metabolism_Homo sapiens_hsa006202.22062389
18Amphetamine addiction_Homo sapiens_hsa050312.19351518
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13654937
20Base excision repair_Homo sapiens_hsa034102.11128232
21Glucagon signaling pathway_Homo sapiens_hsa049222.10791253
22Ribosome_Homo sapiens_hsa030102.07111174
23Linoleic acid metabolism_Homo sapiens_hsa005912.06461128
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96380683
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95815714
26Circadian entrainment_Homo sapiens_hsa047131.94315289
27Propanoate metabolism_Homo sapiens_hsa006401.90841626
28Long-term potentiation_Homo sapiens_hsa047201.86915114
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86909211
30Spliceosome_Homo sapiens_hsa030401.86852253
31Glutamatergic synapse_Homo sapiens_hsa047241.80221876
32Dorso-ventral axis formation_Homo sapiens_hsa043201.80092797
33Nicotine addiction_Homo sapiens_hsa050331.72933087
34Renin secretion_Homo sapiens_hsa049241.70147605
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.68297840
36Nucleotide excision repair_Homo sapiens_hsa034201.67075669
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65621385
38Glycerolipid metabolism_Homo sapiens_hsa005611.64865998
39Butanoate metabolism_Homo sapiens_hsa006501.60958294
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60608716
41Ether lipid metabolism_Homo sapiens_hsa005651.59940977
42RNA degradation_Homo sapiens_hsa030181.59163143
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59055681
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58603020
45Synaptic vesicle cycle_Homo sapiens_hsa047211.56228813
46RNA transport_Homo sapiens_hsa030131.55907198
47Pyrimidine metabolism_Homo sapiens_hsa002401.54777401
48Salivary secretion_Homo sapiens_hsa049701.54343292
49Oocyte meiosis_Homo sapiens_hsa041141.49987564
50Alzheimers disease_Homo sapiens_hsa050101.49737259
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.49159361
52Insulin secretion_Homo sapiens_hsa049111.48546004
53Cardiac muscle contraction_Homo sapiens_hsa042601.48221159
54One carbon pool by folate_Homo sapiens_hsa006701.44559002
55Asthma_Homo sapiens_hsa053101.42522981
56Morphine addiction_Homo sapiens_hsa050321.41233501
57GABAergic synapse_Homo sapiens_hsa047271.40518818
58Mineral absorption_Homo sapiens_hsa049781.37527679
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35635414
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34882683
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33391654
62Gastric acid secretion_Homo sapiens_hsa049711.32216032
63Calcium signaling pathway_Homo sapiens_hsa040201.31315783
64Taste transduction_Homo sapiens_hsa047421.28276289
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21353753
66PPAR signaling pathway_Homo sapiens_hsa033201.20430901
67Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18878664
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18330130
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17626919
70Dopaminergic synapse_Homo sapiens_hsa047281.17288652
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12946147
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12340978
73Olfactory transduction_Homo sapiens_hsa047401.12245752
74Cocaine addiction_Homo sapiens_hsa050301.04272997
75Bile secretion_Homo sapiens_hsa049761.03931011
76Collecting duct acid secretion_Homo sapiens_hsa049661.03901021
77Thyroid hormone synthesis_Homo sapiens_hsa049181.03667277
78cAMP signaling pathway_Homo sapiens_hsa040241.02743224
79Fatty acid metabolism_Homo sapiens_hsa012121.01530480
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01408798
81Basal transcription factors_Homo sapiens_hsa030221.00601866
82Estrogen signaling pathway_Homo sapiens_hsa049151.00475201
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99828381
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98925880
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98218629
86Cell cycle_Homo sapiens_hsa041100.96778287
87Phototransduction_Homo sapiens_hsa047440.95210361
88Pancreatic secretion_Homo sapiens_hsa049720.94955572
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.90344400
90Inositol phosphate metabolism_Homo sapiens_hsa005620.88916160
91Selenocompound metabolism_Homo sapiens_hsa004500.88154762
92Tryptophan metabolism_Homo sapiens_hsa003800.87128477
93beta-Alanine metabolism_Homo sapiens_hsa004100.85307413
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83577267
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82062615
96Fructose and mannose metabolism_Homo sapiens_hsa000510.81897903
97Type II diabetes mellitus_Homo sapiens_hsa049300.81233096
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81123862
99Oxytocin signaling pathway_Homo sapiens_hsa049210.80405473
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78438371
101Sulfur relay system_Homo sapiens_hsa041220.75909082
102Folate biosynthesis_Homo sapiens_hsa007900.75790020
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74351172
104Peroxisome_Homo sapiens_hsa041460.73851818
105Cholinergic synapse_Homo sapiens_hsa047250.72565109
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72097936
107Axon guidance_Homo sapiens_hsa043600.70143963
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69425015
109Fat digestion and absorption_Homo sapiens_hsa049750.67339970
110Serotonergic synapse_Homo sapiens_hsa047260.65356648
111Hedgehog signaling pathway_Homo sapiens_hsa043400.64701569
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63703611
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63427195
114Fatty acid elongation_Homo sapiens_hsa000620.62693322
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.62537128
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61174186
117Metabolic pathways_Homo sapiens_hsa011000.60991093
118Endocytosis_Homo sapiens_hsa041440.60218195
119Long-term depression_Homo sapiens_hsa047300.59512007
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.58551156
121Alcoholism_Homo sapiens_hsa050340.57800482
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.57679688
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56278471
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55161596
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53990403
126Vitamin digestion and absorption_Homo sapiens_hsa049770.53448853
127mRNA surveillance pathway_Homo sapiens_hsa030150.53249939
128Steroid biosynthesis_Homo sapiens_hsa001000.53105033
129Fatty acid degradation_Homo sapiens_hsa000710.50319501
130Allograft rejection_Homo sapiens_hsa053300.48953988
131Graft-versus-host disease_Homo sapiens_hsa053320.48647000
132Pentose phosphate pathway_Homo sapiens_hsa000300.47265086
133Autoimmune thyroid disease_Homo sapiens_hsa053200.47134264
134AMPK signaling pathway_Homo sapiens_hsa041520.46571424
135Type I diabetes mellitus_Homo sapiens_hsa049400.45881915
136ABC transporters_Homo sapiens_hsa020100.45639923
137Huntingtons disease_Homo sapiens_hsa050160.45476884
138Carbon metabolism_Homo sapiens_hsa012000.45082556
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.44204171
140Chemical carcinogenesis_Homo sapiens_hsa052040.43690713
141Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42797603
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.41769534
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41606162
144Regulation of autophagy_Homo sapiens_hsa041400.41397202
145VEGF signaling pathway_Homo sapiens_hsa043700.39718731
146MAPK signaling pathway_Homo sapiens_hsa040100.38796064
147Purine metabolism_Homo sapiens_hsa002300.37678727
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.36504593
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36252638
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35217274
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34920905
152Maturity onset diabetes of the young_Homo sapiens_hsa049500.32608070
153Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31075943
154Ovarian steroidogenesis_Homo sapiens_hsa049130.30811956
155Intestinal immune network for IgA production_Homo sapiens_hsa046720.30644597
156Glutathione metabolism_Homo sapiens_hsa004800.30486512
157Nitrogen metabolism_Homo sapiens_hsa009100.30354063
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.29742751
159Renin-angiotensin system_Homo sapiens_hsa046140.29570496
160Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29280630
161Caffeine metabolism_Homo sapiens_hsa002320.28389891
162Systemic lupus erythematosus_Homo sapiens_hsa053220.28371664
163Steroid hormone biosynthesis_Homo sapiens_hsa001400.27323643
164Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26649944
165Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23976480
166Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23322011
167Histidine metabolism_Homo sapiens_hsa003400.21904965

Most similar genes based on co-expression Upload to Enrichr

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