ADAM1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.91933433
2cell-cell recognition (GO:0009988)9.73916786
3plasma membrane fusion (GO:0045026)9.71398884
4motile cilium assembly (GO:0044458)9.52665869
5spermatid development (GO:0007286)9.35499651
6cell wall macromolecule catabolic process (GO:0016998)9.11860922
7cell wall macromolecule metabolic process (GO:0044036)9.11860922
8male meiosis (GO:0007140)8.84154800
9cilium movement (GO:0003341)8.55010183
10reproduction (GO:0000003)8.52044399
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.51632860
12regulation of cilium movement (GO:0003352)8.40270937
13synaptonemal complex organization (GO:0070193)8.20597315
14synaptonemal complex assembly (GO:0007130)7.72314965
15single fertilization (GO:0007338)7.22018008
16sperm capacitation (GO:0048240)6.88703037
17negative regulation of inclusion body assembly (GO:0090084)6.76982396
18DNA methylation involved in gamete generation (GO:0043046)6.54928237
19fertilization (GO:0009566)6.34864576
20male meiosis I (GO:0007141)6.29547982
21spermatogenesis (GO:0007283)6.21648721
22male gamete generation (GO:0048232)6.19345082
23gamete generation (GO:0007276)5.68797811
24ventricular system development (GO:0021591)5.63028032
25organic cation transport (GO:0015695)5.62623465
26germ cell development (GO:0007281)5.39443335
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.38290997
28chromosome organization involved in meiosis (GO:0070192)5.37294793
29regulation of inclusion body assembly (GO:0090083)5.36871866
30microtubule depolymerization (GO:0007019)5.30657967
31seminiferous tubule development (GO:0072520)5.17887398
32meiotic nuclear division (GO:0007126)5.17090683
33response to pheromone (GO:0019236)5.15595494
34meiosis I (GO:0007127)5.09056306
35calcium ion-dependent exocytosis (GO:0017156)4.99316559
36regulation of microtubule-based movement (GO:0060632)4.98148694
37left/right pattern formation (GO:0060972)4.78251792
38microtubule severing (GO:0051013)4.77649735
39cell recognition (GO:0008037)4.74240953
40protein localization to cilium (GO:0061512)4.62532953
41meiotic cell cycle (GO:0051321)4.61707132
42multicellular organismal reproductive process (GO:0048609)4.47404631
43DNA deamination (GO:0045006)4.17347076
44water-soluble vitamin biosynthetic process (GO:0042364)4.16273686
45behavioral response to nicotine (GO:0035095)3.97265396
46fucose catabolic process (GO:0019317)3.93914419
47L-fucose metabolic process (GO:0042354)3.93914419
48L-fucose catabolic process (GO:0042355)3.93914419
49neural tube formation (GO:0001841)3.93508957
50protein polyglutamylation (GO:0018095)3.91646050
51genitalia morphogenesis (GO:0035112)3.87667115
52spermatid nucleus differentiation (GO:0007289)3.79036760
53monoubiquitinated protein deubiquitination (GO:0035520)3.73771155
54intraciliary transport (GO:0042073)3.72739819
55gene silencing by RNA (GO:0031047)3.63583644
56chaperone-mediated protein complex assembly (GO:0051131)3.62668236
57axoneme assembly (GO:0035082)3.62363512
58amino-acid betaine transport (GO:0015838)3.61929790
59carnitine transport (GO:0015879)3.61929790
60multicellular organismal development (GO:0007275)3.61785777
61chromosome condensation (GO:0030261)3.61385534
62DNA packaging (GO:0006323)3.58672591
63carnitine transmembrane transport (GO:1902603)3.57395322
64indolalkylamine metabolic process (GO:0006586)3.56669430
65glycerol ether metabolic process (GO:0006662)3.55124303
66negative regulation of organelle assembly (GO:1902116)3.52712920
67protein complex biogenesis (GO:0070271)3.46348140
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.39013315
69platelet dense granule organization (GO:0060155)3.36511653
70microtubule-based movement (GO:0007018)3.34040267
71kidney morphogenesis (GO:0060993)3.33840948
72preassembly of GPI anchor in ER membrane (GO:0016254)3.33299109
73ether metabolic process (GO:0018904)3.28522717
74regulation of spindle checkpoint (GO:0090231)3.27452792
75establishment of protein localization to Golgi (GO:0072600)3.23594739
76meiotic cell cycle process (GO:1903046)3.22240528
77protein refolding (GO:0042026)3.21371096
78indole-containing compound catabolic process (GO:0042436)3.19418478
79indolalkylamine catabolic process (GO:0046218)3.19418478
80tryptophan catabolic process (GO:0006569)3.19418478
81synapsis (GO:0007129)3.19249223
82mitochondrial respiratory chain complex assembly (GO:0033108)3.17681314
83lactate metabolic process (GO:0006089)3.17240582
84regulation of meiosis I (GO:0060631)3.17006626
85respiratory chain complex IV assembly (GO:0008535)3.15457867
86cilium organization (GO:0044782)3.12596170
87photoreceptor cell development (GO:0042461)3.10560732
88cytochrome complex assembly (GO:0017004)3.07864573
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07395507
90mitochondrial respiratory chain complex I assembly (GO:0032981)3.07395507
91NADH dehydrogenase complex assembly (GO:0010257)3.07395507
92cornea development in camera-type eye (GO:0061303)3.05897077
93protein targeting to Golgi (GO:0000042)3.05602651
94detection of light stimulus involved in visual perception (GO:0050908)3.04890006
95detection of light stimulus involved in sensory perception (GO:0050962)3.04890006
96photoreceptor cell maintenance (GO:0045494)3.01901392
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00057191
98nonmotile primary cilium assembly (GO:0035058)2.99953325
99mannosylation (GO:0097502)2.98945166
100alditol metabolic process (GO:0019400)2.98856311
101cilium morphogenesis (GO:0060271)2.97938368
102tryptophan metabolic process (GO:0006568)2.97276161
103protein-cofactor linkage (GO:0018065)2.97148973
104nuclear pore complex assembly (GO:0051292)2.95621819
105phosphatidylinositol acyl-chain remodeling (GO:0036149)2.95569824
106cilium assembly (GO:0042384)2.95008322
107GPI anchor metabolic process (GO:0006505)2.93760441
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93712541
109cytidine catabolic process (GO:0006216)2.92297945
110cytidine deamination (GO:0009972)2.92297945
111cytidine metabolic process (GO:0046087)2.92297945
112nucleoside diphosphate phosphorylation (GO:0006165)2.90908051
113retinal cone cell development (GO:0046549)2.90487407
114cellular component assembly involved in morphogenesis (GO:0010927)2.89311576
115polyol catabolic process (GO:0046174)2.87334340
116rhodopsin mediated signaling pathway (GO:0016056)2.86848139
117microtubule polymerization or depolymerization (GO:0031109)2.86770675
118nucleus organization (GO:0006997)2.86063097
119pseudouridine synthesis (GO:0001522)2.84282511
120eye photoreceptor cell development (GO:0042462)2.84098882
121regulation of centriole replication (GO:0046599)2.81413028
122positive regulation of oligodendrocyte differentiation (GO:0048714)2.81366322
123peptidyl-glutamic acid modification (GO:0018200)2.79265006
124inositol phosphate catabolic process (GO:0071545)2.77291756
125RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77139303
126mitotic sister chromatid cohesion (GO:0007064)2.77119276
127rRNA catabolic process (GO:0016075)2.74976638
128regulation of protein polyubiquitination (GO:1902914)2.72393049
129cellular ketone body metabolic process (GO:0046950)2.72353561
130centriole replication (GO:0007099)2.71553640
131interferon-gamma production (GO:0032609)2.70392938
132regulation of action potential (GO:0098900)2.69966141
133protein localization to Golgi apparatus (GO:0034067)2.69500383
134glycolytic process (GO:0006096)2.68435537
135regulation of rhodopsin mediated signaling pathway (GO:0022400)2.65869389
136adenosine metabolic process (GO:0046085)2.64860607
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64449582
138spinal cord motor neuron differentiation (GO:0021522)2.64437153
139gene silencing (GO:0016458)2.64218036
140protein K11-linked deubiquitination (GO:0035871)2.63911362
141indole-containing compound metabolic process (GO:0042430)2.62575909
142branched-chain amino acid catabolic process (GO:0009083)2.62575403
143reflex (GO:0060004)2.62193831
144sex differentiation (GO:0007548)2.60763155
145glycerol metabolic process (GO:0006071)2.60319799
146kynurenine metabolic process (GO:0070189)2.59609995
147negative regulation of telomere maintenance (GO:0032205)2.59165591
148negative regulation of mast cell activation (GO:0033004)2.58612420
149RNA localization (GO:0006403)2.57733405
150ubiquinone biosynthetic process (GO:0006744)2.56706738
151centriole assembly (GO:0098534)2.56274506
152sequestering of actin monomers (GO:0042989)2.55074082
153regulation of chromatin binding (GO:0035561)2.53726835
154cullin deneddylation (GO:0010388)2.53266422
155retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53097813
156tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53021620
157RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53021620
158protein deneddylation (GO:0000338)2.52851773
159pyrimidine ribonucleoside catabolic process (GO:0046133)2.52695977
160negative regulation of skeletal muscle tissue development (GO:0048642)2.52672615
161transepithelial transport (GO:0070633)2.52598513
162embryonic epithelial tube formation (GO:0001838)2.50652237
163DNA demethylation (GO:0080111)2.50629792
164GPI anchor biosynthetic process (GO:0006506)2.49919129
165ncRNA catabolic process (GO:0034661)2.49294200
166amine catabolic process (GO:0009310)2.48785936
167cellular biogenic amine catabolic process (GO:0042402)2.48785936
168regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48439571
169regulation of mitotic spindle checkpoint (GO:1903504)2.48439571
170nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46266360
171somatic diversification of immune receptors via somatic mutation (GO:0002566)2.46185984
172somatic hypermutation of immunoglobulin genes (GO:0016446)2.46185984
173auditory receptor cell stereocilium organization (GO:0060088)2.46001716
174proline transport (GO:0015824)2.45433534
175ketone body metabolic process (GO:1902224)2.43583711
176neuronal action potential (GO:0019228)2.43192087
177cilium or flagellum-dependent cell motility (GO:0001539)14.2130709
178fusion of sperm to egg plasma membrane (GO:0007342)12.7832762
179sperm motility (GO:0030317)12.6444306
180acrosome reaction (GO:0007340)11.2340110
181sperm-egg recognition (GO:0035036)10.9130960
182axonemal dynein complex assembly (GO:0070286)10.8538934
183acrosome assembly (GO:0001675)10.5555193
184multicellular organism reproduction (GO:0032504)10.3644432
185piRNA metabolic process (GO:0034587)10.3171360
186binding of sperm to zona pellucida (GO:0007339)10.1259971

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96151120
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.36436256
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08573716
4IGF1R_20145208_ChIP-Seq_DFB_Human2.79173168
5GBX2_23144817_ChIP-Seq_PC3_Human2.71045927
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48360121
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43616965
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40592646
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37322186
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35002103
11VDR_22108803_ChIP-Seq_LS180_Human2.27352473
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19887797
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.17297178
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.11966495
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09003222
16FUS_26573619_Chip-Seq_HEK293_Human2.07397182
17P300_19829295_ChIP-Seq_ESCs_Human2.03050211
18ER_23166858_ChIP-Seq_MCF-7_Human2.02507601
19ZNF274_21170338_ChIP-Seq_K562_Hela2.01026039
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.8876161
21EWS_26573619_Chip-Seq_HEK293_Human1.98703686
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96840471
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.90138892
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89867298
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88463972
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85920491
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.76123513
28BCAT_22108803_ChIP-Seq_LS180_Human1.70574470
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67512094
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.67078967
31TP53_22573176_ChIP-Seq_HFKS_Human1.64111557
32STAT1_17558387_ChIP-Seq_HELA_Human1.57479464
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55681821
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54993589
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54237978
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54138944
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.52380317
38FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51897589
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50682786
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.50614130
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.50603530
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49834283
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48628011
44IRF1_19129219_ChIP-ChIP_H3396_Human1.47713137
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.46016276
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.45626578
47MYC_18940864_ChIP-ChIP_HL60_Human1.45265417
48AR_25329375_ChIP-Seq_VCAP_Human1.42559268
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.41973971
50CBP_20019798_ChIP-Seq_JUKART_Human1.40475469
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40475469
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40162344
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38131247
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.37645747
55ELK1_19687146_ChIP-ChIP_HELA_Human1.37599892
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36330189
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35615674
58SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35458373
59SMAD4_21799915_ChIP-Seq_A2780_Human1.35127537
60STAT3_23295773_ChIP-Seq_U87_Human1.34404232
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.34274095
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33922904
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33231855
64VDR_23849224_ChIP-Seq_CD4+_Human1.33096625
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.32875818
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32875818
67SOX2_19829295_ChIP-Seq_ESCs_Human1.31605845
68NANOG_19829295_ChIP-Seq_ESCs_Human1.31605845
69AR_20517297_ChIP-Seq_VCAP_Human1.29504950
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.28156902
71REST_21632747_ChIP-Seq_MESCs_Mouse1.27579565
72NCOR_22424771_ChIP-Seq_293T_Human1.25250785
73TCF4_22108803_ChIP-Seq_LS180_Human1.24134106
74KDM2B_26808549_Chip-Seq_REH_Human1.22641023
75FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22113057
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21496145
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21255966
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.20093652
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20018371
80RUNX2_22187159_ChIP-Seq_PCA_Human1.19762141
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19413349
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.19318938
83SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19306215
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.18226350
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18129891
86* GATA3_21867929_ChIP-Seq_CD8_Mouse1.18067240
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15878981
88LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15652816
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15458080
90P53_21459846_ChIP-Seq_SAOS-2_Human1.15323658
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15285832
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15267270
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15248961
94KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15069763
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14715307
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14715307
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14132644
98GATA3_21878914_ChIP-Seq_MCF-7_Human1.13962242
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13769583
100HOXB7_26014856_ChIP-Seq_BT474_Human1.13064628
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12039586
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11527902
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.10498036
104CDX2_22108803_ChIP-Seq_LS180_Human1.09919888
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.08507172
106* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06770976
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06292469
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06205780
109GATA3_21867929_ChIP-Seq_TH1_Mouse1.05909059
110GF1_26923725_Chip-Seq_HPCs_Mouse1.05532611
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05252419
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.04661587
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03010470
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.02676735
115RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01729145
116ERG_20517297_ChIP-Seq_VCAP_Human1.01614574
117CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01544685
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00991808
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.00563294
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.00472061
121FOXP3_21729870_ChIP-Seq_TREG_Human0.99268990
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98780618
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98635390
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96756205
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96688729
126EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96622805
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.96403613
128MYC_19829295_ChIP-Seq_ESCs_Human0.94957981
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94771880
130OCT4_18555785_Chip-Seq_ESCs_Mouse0.94507117
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.94464184
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93491314
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93258657
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93189384
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92696820
136P53_22387025_ChIP-Seq_ESCs_Mouse0.92267017
137MYC_27129775_Chip-Seq_CORNEA_Mouse0.91207279
138SOX2_21211035_ChIP-Seq_LN229_Human0.91161723
139RNF2_27304074_Chip-Seq_NSC_Mouse0.91059398
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90841554
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.90258884
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89361815
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88751400
144RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88260515
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88206308
146NFYB_21822215_ChIP-Seq_K562_Human0.88188555
147TAF15_26573619_Chip-Seq_HEK293_Human0.88120583
148CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87973002
149P300_18555785_Chip-Seq_ESCs_Mouse0.87813104
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.87608297
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87233269
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86915736
153KLF4_18555785_Chip-Seq_ESCs_Mouse0.86019796
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.86019587
155TBL1_22424771_ChIP-Seq_293T_Human0.85469736
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.84963093
157CTCF_20526341_ChIP-Seq_ESCs_Human0.84850662
158GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82631288
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82619635
160NANOG_20526341_ChIP-Seq_ESCs_Human0.82466480
161TCF4_23295773_ChIP-Seq_U87_Human0.82317535
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81522305
163CMYC_18555785_Chip-Seq_ESCs_Mouse0.81428578
164RARA_24833708_ChIP-Seq_LIVER_Mouse0.81240827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.98549710
2MP0001929_abnormal_gametogenesis5.46180925
3MP0008877_abnormal_DNA_methylation4.75909091
4MP0002210_abnormal_sex_determination3.68343657
5MP0002161_abnormal_fertility/fecundity3.22845908
6MP0001145_abnormal_male_reproductive3.09643540
7MP0003195_calcinosis2.81946823
8MP0002653_abnormal_ependyma_morphology2.79851311
9MP0006072_abnormal_retinal_apoptosis2.75661247
10MP0000653_abnormal_sex_gland2.67535158
11MP0002638_abnormal_pupillary_reflex2.57062822
12MP0003787_abnormal_imprinting2.43576301
13MP0006292_abnormal_olfactory_placode2.30184596
14MP0002876_abnormal_thyroid_physiology2.17927350
15MP0002160_abnormal_reproductive_system2.15339897
16MP0001968_abnormal_touch/_nociception2.08951832
17MP0005670_abnormal_white_adipose2.06679646
18MP0003646_muscle_fatigue2.00422307
19MP0005410_abnormal_fertilization15.6504412
20MP0005623_abnormal_meninges_morphology1.99620341
21MP0008875_abnormal_xenobiotic_pharmacok1.97297076
22MP0002837_dystrophic_cardiac_calcinosis1.90081519
23MP0006276_abnormal_autonomic_nervous1.87702968
24MP0005646_abnormal_pituitary_gland1.83963465
25MP0003880_abnormal_central_pattern1.77371242
26MP0001919_abnormal_reproductive_system1.76352531
27MP0004147_increased_porphyrin_level1.68497367
28MP0001501_abnormal_sleep_pattern1.61208742
29MP0001986_abnormal_taste_sensitivity1.60490874
30MP0001529_abnormal_vocalization1.58001432
31MP0008872_abnormal_physiological_respon1.55815533
32MP0002736_abnormal_nociception_after1.49183652
33MP0005084_abnormal_gallbladder_morpholo1.45009541
34MP0002254_reproductive_system_inflammat1.41893202
35MP0001486_abnormal_startle_reflex1.41172956
36MP0009046_muscle_twitch1.38667813
37MP0004142_abnormal_muscle_tone1.38344823
38MP0009745_abnormal_behavioral_response1.38081979
39MP0002751_abnormal_autonomic_nervous1.31427750
40MP0005167_abnormal_blood-brain_barrier1.31242865
41MP0002138_abnormal_hepatobiliary_system1.27316542
42MP0008057_abnormal_DNA_replication1.27279901
43MP0002282_abnormal_trachea_morphology1.25862709
44MP0004885_abnormal_endolymph1.25339698
45MP0001485_abnormal_pinna_reflex1.20808387
46MP0005379_endocrine/exocrine_gland_phen1.18689947
47MP0000631_abnormal_neuroendocrine_gland1.18020390
48MP0002909_abnormal_adrenal_gland1.17861376
49MP0004233_abnormal_muscle_weight1.17845667
50MP0005174_abnormal_tail_pigmentation1.17030761
51MP0001905_abnormal_dopamine_level1.16812520
52MP0003718_maternal_effect1.14997073
53MP0000427_abnormal_hair_cycle1.13434420
54MP0005671_abnormal_response_to1.10579414
55MP0005332_abnormal_amino_acid1.09425737
56MP0001970_abnormal_pain_threshold1.09223114
57MP0002938_white_spotting1.06897858
58MP0001984_abnormal_olfaction1.06462248
59MP0005075_abnormal_melanosome_morpholog1.05132937
60MP0008789_abnormal_olfactory_epithelium1.04971994
61MP0005386_behavior/neurological_phenoty1.03130191
62MP0004924_abnormal_behavior1.03130191
63MP0005647_abnormal_sex_gland1.02254747
64MP0000372_irregular_coat_pigmentation1.01539619
65MP0003806_abnormal_nucleotide_metabolis1.01158983
66MP0005389_reproductive_system_phenotype0.99691462
67MP0003136_yellow_coat_color0.99445578
68MP0001765_abnormal_ion_homeostasis0.98994708
69MP0000647_abnormal_sebaceous_gland0.98344611
70MP0008995_early_reproductive_senescence0.97591117
71MP0008775_abnormal_heart_ventricle0.97408022
72MP0004215_abnormal_myocardial_fiber0.95840113
73MP0002557_abnormal_social/conspecific_i0.94810009
74MP0000230_abnormal_systemic_arterial0.91504326
75MP0002733_abnormal_thermal_nociception0.91143400
76MP0003567_abnormal_fetal_cardiomyocyte0.90955216
77MP0008058_abnormal_DNA_repair0.87286500
78MP0003121_genomic_imprinting0.87174133
79MP0002064_seizures0.86842349
80MP0003011_delayed_dark_adaptation0.86763665
81MP0003950_abnormal_plasma_membrane0.86469397
82MP0003137_abnormal_impulse_conducting0.84296723
83MP0010094_abnormal_chromosome_stability0.83225231
84MP0003878_abnormal_ear_physiology0.82578552
85MP0005377_hearing/vestibular/ear_phenot0.82578552
86MP0000569_abnormal_digit_pigmentation0.82122933
87MP0005085_abnormal_gallbladder_physiolo0.80968180
88MP0002752_abnormal_somatic_nervous0.80352963
89MP0004085_abnormal_heartbeat0.80068699
90MP0004145_abnormal_muscle_electrophysio0.79726300
91MP0002277_abnormal_respiratory_mucosa0.79651078
92MP0009764_decreased_sensitivity_to0.78917784
93MP0004484_altered_response_of0.78380902
94MP0005394_taste/olfaction_phenotype0.75384695
95MP0005499_abnormal_olfactory_system0.75384695
96MP0002735_abnormal_chemical_nociception0.75047477
97MP0000358_abnormal_cell_content/0.72190171
98MP0003329_amyloid_beta_deposits0.71002447
99MP0003786_premature_aging0.69047424
100MP0003115_abnormal_respiratory_system0.65074227
101MP0002234_abnormal_pharynx_morphology0.64207247
102MP0000751_myopathy0.58842748
103MP0001661_extended_life_span0.56703580
104MP0008007_abnormal_cellular_replicative0.55023533
105MP0004134_abnormal_chest_morphology0.52202606
106MP0009278_abnormal_bone_marrow0.52145020
107MP0001324_abnormal_eye_pigmentation0.51040331
108MP0005551_abnormal_eye_electrophysiolog0.50328207
109MP0005636_abnormal_mineral_homeostasis0.48747609
110MP0001293_anophthalmia0.48465095
111MP0005666_abnormal_adipose_tissue0.48287550
112MP0001727_abnormal_embryo_implantation0.47721427
113MP0005253_abnormal_eye_physiology0.47399419
114MP0001545_abnormal_hematopoietic_system0.45811459
115MP0005397_hematopoietic_system_phenotyp0.45811459
116MP0004036_abnormal_muscle_relaxation0.44530318
117MP0003699_abnormal_female_reproductive0.44419291
118MP0000920_abnormal_myelination0.40174645
119MP0002269_muscular_atrophy0.39945514
120MP0005391_vision/eye_phenotype0.39837585
121MP0005423_abnormal_somatic_nervous0.36891758
122MP0003879_abnormal_hair_cell0.36277169
123MP0005645_abnormal_hypothalamus_physiol0.35989726
124MP0003045_fibrosis0.35773739
125MP0003111_abnormal_nucleus_morphology0.35701537
126MP0006036_abnormal_mitochondrial_physio0.35114825
127MP0004043_abnormal_pH_regulation0.33051641
128MP0006035_abnormal_mitochondrial_morpho0.33027703
129MP0002152_abnormal_brain_morphology0.31198178
130MP0002928_abnormal_bile_duct0.30665048
131MP0001851_eye_inflammation0.30661416
132MP0003633_abnormal_nervous_system0.30562272
133MP0004270_analgesia0.30463273
134MP0004808_abnormal_hematopoietic_stem0.30149924
135MP0002108_abnormal_muscle_morphology0.29532240
136MP0000604_amyloidosis0.29485114
137MP0004811_abnormal_neuron_physiology0.29230947
138MP0004742_abnormal_vestibular_system0.29124891
139MP0003861_abnormal_nervous_system0.29014940
140MP0001440_abnormal_grooming_behavior0.28961296
141MP0008961_abnormal_basal_metabolism0.28881330
142MP0002229_neurodegeneration0.28231837
143MP0002295_abnormal_pulmonary_circulatio0.28181491
144MP0000749_muscle_degeneration0.27447806
145MP0009115_abnormal_fat_cell0.26791002
146MP0002092_abnormal_eye_morphology0.26560378
147MP0002971_abnormal_brown_adipose0.26262820
148MP0003631_nervous_system_phenotype0.26014172
149MP0001730_embryonic_growth_arrest0.24035118
150MP0005375_adipose_tissue_phenotype0.23783092
151MP0000534_abnormal_ureter_morphology0.22899874
152MP0001119_abnormal_female_reproductive0.22843431
153MP0001764_abnormal_homeostasis0.22656864
154MP0000313_abnormal_cell_death0.21994602
155MP0004019_abnormal_vitamin_homeostasis0.21664146
156MP0002272_abnormal_nervous_system0.21413950
157MP0005195_abnormal_posterior_eye0.20712266
158MP0003634_abnormal_glial_cell0.20467434
159MP0002102_abnormal_ear_morphology0.20149219
160MP0005365_abnormal_bile_salt0.20099934
161MP0000015_abnormal_ear_pigmentation0.19379120
162MP0004133_heterotaxia0.19069465
163MP0010307_abnormal_tumor_latency0.18657497
164MP0002572_abnormal_emotion/affect_behav0.18290594
165MP0003959_abnormal_lean_body0.17974607
166MP0008569_lethality_at_weaning0.17544635
167MP0003948_abnormal_gas_homeostasis0.17446837

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.13964972
2Abnormal respiratory motile cilium morphology (HP:0005938)8.83531425
3Abnormal respiratory epithelium morphology (HP:0012253)8.83531425
4Rhinitis (HP:0012384)7.81788238
5Abnormal ciliary motility (HP:0012262)7.17084960
6Chronic bronchitis (HP:0004469)7.03497603
7Infertility (HP:0000789)6.51947298
8Nasal polyposis (HP:0100582)6.24925059
9Abnormality of the nasal mucosa (HP:0000433)5.11641642
10Nephronophthisis (HP:0000090)4.83439495
11Bronchiectasis (HP:0002110)4.51901159
12Bronchitis (HP:0012387)4.39476886
13Pancreatic cysts (HP:0001737)4.36986735
14Pancreatic fibrosis (HP:0100732)4.11062809
15Congenital stationary night blindness (HP:0007642)3.91171785
16True hermaphroditism (HP:0010459)3.72116300
17Abnormality of the renal medulla (HP:0100957)3.69031017
18Male infertility (HP:0003251)3.63422571
19Abnormality of the lower motor neuron (HP:0002366)3.42558365
20Type II lissencephaly (HP:0007260)3.36234687
21Attenuation of retinal blood vessels (HP:0007843)3.30122522
22Recurrent otitis media (HP:0000403)3.29918851
23Hyperventilation (HP:0002883)3.20114055
24Gonadotropin excess (HP:0000837)3.08402996
25Tubulointerstitial nephritis (HP:0001970)3.06520690
26Acute necrotizing encephalopathy (HP:0006965)3.05867037
27Abnormal rod and cone electroretinograms (HP:0008323)3.05519488
28Abnormal spermatogenesis (HP:0008669)3.01896287
29Recurrent sinusitis (HP:0011108)3.01041685
30Tubular atrophy (HP:0000092)2.95080468
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87571836
32Abolished electroretinogram (ERG) (HP:0000550)2.86920571
33Progressive macrocephaly (HP:0004481)2.84416901
34Hypothermia (HP:0002045)2.79955637
35Pendular nystagmus (HP:0012043)2.73161698
36Abnormality of midbrain morphology (HP:0002418)2.70694810
37Molar tooth sign on MRI (HP:0002419)2.70694810
38Acute encephalopathy (HP:0006846)2.70638064
39Amyotrophic lateral sclerosis (HP:0007354)2.70433125
40Renal cortical cysts (HP:0000803)2.66327158
41Abnormal mitochondria in muscle tissue (HP:0008316)2.63778766
42Recurrent bronchitis (HP:0002837)2.63463074
43Tubulointerstitial abnormality (HP:0001969)2.62834358
44Increased CSF lactate (HP:0002490)2.61934137
45Ketoacidosis (HP:0001993)2.61133852
46Mitochondrial inheritance (HP:0001427)2.50876288
47Lissencephaly (HP:0001339)2.46428320
48Impulsivity (HP:0100710)2.43884986
49Methylmalonic aciduria (HP:0012120)2.42953812
50Medial flaring of the eyebrow (HP:0010747)2.40918671
51Fibular hypoplasia (HP:0003038)2.40189684
52Congenital primary aphakia (HP:0007707)2.35290282
53Anencephaly (HP:0002323)2.34670039
54Gait imbalance (HP:0002141)2.34375478
553-Methylglutaconic aciduria (HP:0003535)2.33649484
56Nephrogenic diabetes insipidus (HP:0009806)2.31952405
57Hyperglycinuria (HP:0003108)2.30886890
58Impaired proprioception (HP:0010831)2.28121276
59Optic disc pallor (HP:0000543)2.24649567
60Chronic hepatic failure (HP:0100626)2.22945379
61Azoospermia (HP:0000027)2.21491646
62Keratoconus (HP:0000563)2.19082460
63Increased corneal curvature (HP:0100692)2.19082460
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18799153
65Stage 5 chronic kidney disease (HP:0003774)2.18390888
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17060705
67Abnormality of alanine metabolism (HP:0010916)2.17060705
68Hyperalaninemia (HP:0003348)2.17060705
69Tubulointerstitial fibrosis (HP:0005576)2.14728863
70Ketosis (HP:0001946)2.14073204
71Postaxial foot polydactyly (HP:0001830)2.12800172
72Optic nerve hypoplasia (HP:0000609)2.11682502
73Large for gestational age (HP:0001520)2.11669010
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10613637
75Inability to walk (HP:0002540)2.09839892
76Methylmalonic acidemia (HP:0002912)2.09187784
77Polydipsia (HP:0001959)2.08794972
78Abnormal drinking behavior (HP:0030082)2.08794972
79Genital tract atresia (HP:0001827)2.08025627
80Absent speech (HP:0001344)2.06519116
81Bony spicule pigmentary retinopathy (HP:0007737)2.06420583
82Intestinal atresia (HP:0011100)2.02696638
83Sclerocornea (HP:0000647)2.02466794
84Vaginal atresia (HP:0000148)2.02235427
85Hypomagnesemia (HP:0002917)2.02147483
86Decreased circulating renin level (HP:0003351)2.01589243
87Disproportionate short-trunk short stature (HP:0003521)2.00887551
88Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00373148
89Progressive inability to walk (HP:0002505)2.00141801
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2328563
91Dynein arm defect of respiratory motile cilia (HP:0012255)12.5732108
92Absent/shortened dynein arms (HP:0200106)12.5732108
93Spastic tetraparesis (HP:0001285)1.98199677
94Abnormal gallbladder physiology (HP:0012438)1.98125813
95Cholecystitis (HP:0001082)1.98125813
96Broad-based gait (HP:0002136)1.97672666
97Furrowed tongue (HP:0000221)1.97341523
98Severe muscular hypotonia (HP:0006829)1.94649375
99Short ribs (HP:0000773)1.93960781
100Increased serum lactate (HP:0002151)1.91210623
101Abnormality of the renal cortex (HP:0011035)1.91027647
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.89942607
103Hepatocellular necrosis (HP:0001404)1.89718578
104Male pseudohermaphroditism (HP:0000037)1.89370754
105Upper motor neuron abnormality (HP:0002127)1.88932455
106Oculomotor apraxia (HP:0000657)1.88364315
107Congenital hepatic fibrosis (HP:0002612)1.87590668
108Tachypnea (HP:0002789)1.86479054
109Stomach cancer (HP:0012126)1.86109375
110Cerebral edema (HP:0002181)1.86091694
111Hepatic necrosis (HP:0002605)1.85296586
112Bell-shaped thorax (HP:0001591)1.84971106
113Lethargy (HP:0001254)1.84851970
114Colon cancer (HP:0003003)1.83442668
115Absent epiphyses (HP:0010577)1.83312884
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83312884
117Abnormality of the pons (HP:0007361)1.82752435
118Lipid accumulation in hepatocytes (HP:0006561)1.82491030
119Lactic acidosis (HP:0003128)1.81353339
120Abnormality of dentin (HP:0010299)1.81327456
121Abnormality of serine family amino acid metabolism (HP:0010894)1.80777991
122Abnormality of glycine metabolism (HP:0010895)1.80777991
123Thyroiditis (HP:0100646)1.78111958
124Febrile seizures (HP:0002373)1.77740367
125Bilateral microphthalmos (HP:0007633)1.77452785
126Absent frontal sinuses (HP:0002688)1.75058351
127Heterotopia (HP:0002282)1.74148864
128Agitation (HP:0000713)1.73950276
129Renal dysplasia (HP:0000110)1.73801600
130Occipital encephalocele (HP:0002085)1.73500823
131Absent thumb (HP:0009777)1.72349355
132Progressive microcephaly (HP:0000253)1.70978845
133Increased hepatocellular lipid droplets (HP:0006565)1.69858381
134Abnormality of permanent molar morphology (HP:0011071)1.69448531
135Abnormality of the dental root (HP:0006486)1.69448531
136Taurodontia (HP:0000679)1.69448531
137Abnormality of renal excretion (HP:0011036)1.68802512
138J-shaped sella turcica (HP:0002680)1.68796035
139Degeneration of anterior horn cells (HP:0002398)1.67041173
140Abnormality of the anterior horn cell (HP:0006802)1.67041173
141Dyschromatopsia (HP:0007641)1.65351308
142Short thorax (HP:0010306)1.63539772
143Microglossia (HP:0000171)1.60713029
144Abnormality of molar (HP:0011077)1.60568914
145Abnormality of molar morphology (HP:0011070)1.60568914
146Choroideremia (HP:0001139)1.60065366
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59973275
148Postaxial hand polydactyly (HP:0001162)1.59421109
149Bile duct proliferation (HP:0001408)1.57494768
150Abnormal biliary tract physiology (HP:0012439)1.57494768
151Aplasia/Hypoplasia of the fibula (HP:0006492)1.53295534
152Supernumerary spleens (HP:0009799)1.52920493
153Abnormality of the dental pulp (HP:0006479)1.51969170
154Retinal dysplasia (HP:0007973)1.48627438
155Decreased motor nerve conduction velocity (HP:0003431)1.48058916
156Facial cleft (HP:0002006)1.47837968
157Chronic sinusitis (HP:0011109)1.47757442
158Short femoral neck (HP:0100864)1.47622433
159Neurofibrillary tangles (HP:0002185)1.45376438
160Nephropathy (HP:0000112)1.43046385
161Median cleft lip (HP:0000161)1.41902948
162Abnormal urine output (HP:0012590)1.40446147
163Pachygyria (HP:0001302)1.38053453
164Deformed sella turcica (HP:0002681)1.37325506
165Broad distal phalanx of finger (HP:0009836)1.37285316
166Cerebellar dysplasia (HP:0007033)1.33148721
167Conjunctival telangiectasia (HP:0000524)1.32994483
168Gaze-evoked nystagmus (HP:0000640)1.32058490
169Cystic liver disease (HP:0006706)1.30822127
170Hemorrhage of the eye (HP:0011885)1.30262518
171Decreased central vision (HP:0007663)1.30064153
172Polyuria (HP:0000103)1.29790229
173Hemiparesis (HP:0001269)1.28819066
174Abnormality of ocular smooth pursuit (HP:0000617)1.28724079
175Aplasia/Hypoplasia of the lens (HP:0008063)1.26841826
176Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.25518832
177Hyporeflexia of lower limbs (HP:0002600)1.25321457
178Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.23658907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.35582275
2PDK38.35582275
3TESK15.67426335
4PDK25.44758297
5FRK4.95460747
6PRKD34.65898786
7ICK3.98696122
8MAP4K23.97219043
9TXK3.05868277
10ADRBK22.86690895
11PNCK2.72531110
12ACVR1B2.70064006
13STK392.68200778
14GRK12.68008738
15WNK42.59483586
16PTK2B2.55754692
17TAOK32.51710031
18TIE12.06804293
19ZAK1.97932417
20NUAK11.86051053
21TLK11.85332936
22NEK21.81791787
23STK381.64639580
24CASK1.55823308
25MKNK11.55157101
26MKNK21.46360100
27MAPK131.36849475
28MAP2K71.36134040
29CAMKK21.30836344
30INSRR1.27959991
31WNK11.27048093
32MAPK151.21776539
33TEC1.21517806
34DYRK1B1.16665753
35PAK31.14657253
36EPHA31.14315335
37BCR1.13731360
38DYRK21.13542959
39TNIK1.09716624
40EIF2AK31.05299451
41TRIM281.03917496
42EPHA41.03590734
43TGFBR10.99494118
44TYRO30.95274806
45PDK10.94885662
46TESK20.91933623
47CSNK1G20.89434993
48PLK20.87818626
49PRKCE0.87593434
50ERBB30.86741464
51CSNK1G10.86081612
52MST40.83320803
53STK30.83229739
54ITK0.76844928
55CSNK1G30.76387388
56VRK10.76124843
57ADRBK10.74092767
58PASK0.73630171
59PHKG20.72554983
60PHKG10.72554983
61NLK0.71910408
62CAMK1G0.71403638
63FGFR20.70948254
64CCNB10.68878659
65PINK10.65157905
66TTK0.64872095
67NME10.64576893
68MUSK0.63701666
69FER0.63674812
70IKBKB0.62905665
71RPS6KA50.62835283
72LIMK10.62771947
73CSNK1A1L0.62480365
74DYRK30.62273625
75PLK30.60809114
76MARK10.60514277
77BCKDK0.59386112
78DAPK20.59341546
79SYK0.56168760
80IRAK10.55081191
81TNK20.54975093
82CDC70.54556736
83SIK20.53821873
84CAMK10.53214220
85GRK60.52427612
86SRPK10.52181117
87FLT30.52155366
88CDK80.51032152
89CSNK1A10.49048588
90CHUK0.48925276
91FES0.47938074
92CDK120.46835795
93VRK20.45733089
94GRK50.45704749
95BMPR1B0.44770186
96PDPK10.44718458
97CHEK20.42724451
98CHEK10.42722352
99MAP4K10.42055013
100PRKACA0.41805663
101NTRK20.40935099
102PRKAA20.40051355
103ATR0.37025795
104MAPKAPK50.35814524
105MTOR0.35439237
106BMPR20.35197760
107NTRK30.35191627
108ERBB20.33779391
109LYN0.33206096
110ATM0.33082371
111PAK10.33076743
112CAMK2D0.32945560
113MAP3K70.32864780
114IGF1R0.32432499
115WEE10.32337625
116IRAK20.32110164
117MAP2K60.31823545
118KIT0.31743109
119EEF2K0.31094524
120BTK0.30983009
121PAK20.30807934
122NEK60.27581188
123MARK20.25796127
124LMTK20.25039315
125PRKAA10.21514790
126EPHB10.20908764
127PRKCG0.19424351
128STK38L0.18479604
129CAMKK10.18132475
130RPS6KB10.15755021
131PKN10.14630260
132RIPK40.13954368
133PLK10.12129265
134OBSCN0.11817154
135CLK10.11124585
136CSF1R0.11111426
137CSNK1D0.10982841
138PRKCQ0.10501354
139STK110.08566375
140PLK40.05982671
141WNK30.05426145
142PRKACB0.05107694
143GSK3B0.04698715
144PRKCZ0.04639236
145PRKG10.04507133
146CAMK2A0.04427707
147MET0.04424405
148PAK40.03932275
149CDK10.03725476
150BRAF0.02782620
151MAPK80.02385637
152PRKDC0.02068829
153CSNK2A10.01519549
154RPS6KA10.01465370
155CDK150.01445025
156CDK20.00939648
157PRKACG0.00797129
158PDGFRB0.00612401
159YES1-0.0390441
160PRKCA-0.0375216
161TAOK1-0.0363810
162MAPK10-0.0326294
163ZAP70-0.0296858
164MAPK1-0.0292097
165PAK6-0.0282542
166CDK14-0.0262876
167EGFR-0.0252014
168MARK3-0.0223062
169CSNK2A2-0.0219544
170CSK-0.0211904
171CDK11A-0.0200160
172RPS6KA3-0.0147110
173CDK3-0.0144474
174CDK18-0.0113396
175OXSR1-0.0066306
176PRKCB-0.0016021
177MAP3K4-0.0003672

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.74927700
2Pyruvate metabolism_Homo sapiens_hsa006204.09473110
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.01285203
4Fatty acid biosynthesis_Homo sapiens_hsa000613.65015676
5Propanoate metabolism_Homo sapiens_hsa006403.14163225
6Phototransduction_Homo sapiens_hsa047443.07697879
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91291804
8Linoleic acid metabolism_Homo sapiens_hsa005912.81101253
9Glucagon signaling pathway_Homo sapiens_hsa049222.74683679
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67394937
11Dorso-ventral axis formation_Homo sapiens_hsa043202.63928651
12Basal transcription factors_Homo sapiens_hsa030222.49958916
13Selenocompound metabolism_Homo sapiens_hsa004502.49740597
14Oxidative phosphorylation_Homo sapiens_hsa001902.46939861
15Protein export_Homo sapiens_hsa030602.46616218
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37625260
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18531990
18RNA polymerase_Homo sapiens_hsa030202.13236988
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11561837
20Glycerolipid metabolism_Homo sapiens_hsa005612.06994737
21Fanconi anemia pathway_Homo sapiens_hsa034602.04841824
22Nitrogen metabolism_Homo sapiens_hsa009102.04833677
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04144086
24Butanoate metabolism_Homo sapiens_hsa006501.97984238
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.96131754
26Homologous recombination_Homo sapiens_hsa034401.95773845
27Huntingtons disease_Homo sapiens_hsa050161.94458388
28Parkinsons disease_Homo sapiens_hsa050121.87260177
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.86343833
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84624363
31Caffeine metabolism_Homo sapiens_hsa002321.84066985
32Pentose phosphate pathway_Homo sapiens_hsa000301.81263303
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77947348
34Oocyte meiosis_Homo sapiens_hsa041141.77450324
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76351641
36Tryptophan metabolism_Homo sapiens_hsa003801.75762190
37Amphetamine addiction_Homo sapiens_hsa050311.71504213
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65260810
39PPAR signaling pathway_Homo sapiens_hsa033201.63618596
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61955733
41Ether lipid metabolism_Homo sapiens_hsa005651.57929048
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.54719163
43Cardiac muscle contraction_Homo sapiens_hsa042601.49130669
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.46401611
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44407674
46Renin secretion_Homo sapiens_hsa049241.40420856
47Fat digestion and absorption_Homo sapiens_hsa049751.36647487
48Non-homologous end-joining_Homo sapiens_hsa034501.33208407
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32594285
50Fructose and mannose metabolism_Homo sapiens_hsa000511.31056515
51Fatty acid metabolism_Homo sapiens_hsa012121.28886384
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.27092594
53Nicotine addiction_Homo sapiens_hsa050331.26107493
54mRNA surveillance pathway_Homo sapiens_hsa030151.21821221
55Proteasome_Homo sapiens_hsa030501.20909347
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20894989
57Peroxisome_Homo sapiens_hsa041461.19330315
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14135071
59Carbon metabolism_Homo sapiens_hsa012001.13887177
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11717888
61Olfactory transduction_Homo sapiens_hsa047401.09584101
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.09546225
63One carbon pool by folate_Homo sapiens_hsa006701.08726036
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06967992
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06770816
66Mineral absorption_Homo sapiens_hsa049781.05485917
67Regulation of autophagy_Homo sapiens_hsa041401.04472252
68Fatty acid degradation_Homo sapiens_hsa000711.04466977
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99569865
70ABC transporters_Homo sapiens_hsa020100.99425157
71Antigen processing and presentation_Homo sapiens_hsa046120.98971099
72Morphine addiction_Homo sapiens_hsa050320.98433798
73Type I diabetes mellitus_Homo sapiens_hsa049400.98105673
74RNA transport_Homo sapiens_hsa030130.96913529
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.95635222
76Ovarian steroidogenesis_Homo sapiens_hsa049130.95452889
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94180680
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91264602
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.90578555
80Long-term potentiation_Homo sapiens_hsa047200.88456577
81Graft-versus-host disease_Homo sapiens_hsa053320.86199622
82Purine metabolism_Homo sapiens_hsa002300.83588228
83Glutathione metabolism_Homo sapiens_hsa004800.82494813
84Asthma_Homo sapiens_hsa053100.81840425
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79648533
86GABAergic synapse_Homo sapiens_hsa047270.77316722
87Primary immunodeficiency_Homo sapiens_hsa053400.76886710
88beta-Alanine metabolism_Homo sapiens_hsa004100.75217194
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73859332
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73485446
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73286351
92Serotonergic synapse_Homo sapiens_hsa047260.73222233
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73145912
94Autoimmune thyroid disease_Homo sapiens_hsa053200.72808327
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71732600
96Estrogen signaling pathway_Homo sapiens_hsa049150.70918299
97Arachidonic acid metabolism_Homo sapiens_hsa005900.69563058
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69469794
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68969363
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68031733
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67921714
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66287859
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.62936033
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62547838
105Systemic lupus erythematosus_Homo sapiens_hsa053220.61203064
106Calcium signaling pathway_Homo sapiens_hsa040200.61088600
107Collecting duct acid secretion_Homo sapiens_hsa049660.60629923
108Allograft rejection_Homo sapiens_hsa053300.59197140
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58017795
110Biosynthesis of amino acids_Homo sapiens_hsa012300.57767370
111Hedgehog signaling pathway_Homo sapiens_hsa043400.56910112
112Circadian rhythm_Homo sapiens_hsa047100.55934700
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55307352
114VEGF signaling pathway_Homo sapiens_hsa043700.54810524
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.54679314
116Vitamin digestion and absorption_Homo sapiens_hsa049770.54401738
117Rheumatoid arthritis_Homo sapiens_hsa053230.52661629
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52350408
119Chemical carcinogenesis_Homo sapiens_hsa052040.51892892
120Insulin secretion_Homo sapiens_hsa049110.49916287
121Sphingolipid metabolism_Homo sapiens_hsa006000.49487246
122AMPK signaling pathway_Homo sapiens_hsa041520.48472016
123Pancreatic secretion_Homo sapiens_hsa049720.47632459
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47360907
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44369798
126N-Glycan biosynthesis_Homo sapiens_hsa005100.44330812
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43636697
128Mismatch repair_Homo sapiens_hsa034300.43595569
129Thyroid hormone synthesis_Homo sapiens_hsa049180.43566617
130Circadian entrainment_Homo sapiens_hsa047130.42668724
131Endocytosis_Homo sapiens_hsa041440.42592485
132Sulfur metabolism_Homo sapiens_hsa009200.42107839
133Protein digestion and absorption_Homo sapiens_hsa049740.41699680
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40846947
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.39927736
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39884188
137Steroid biosynthesis_Homo sapiens_hsa001000.39093255
138Taste transduction_Homo sapiens_hsa047420.39031501
139Legionellosis_Homo sapiens_hsa051340.38794074
140Bile secretion_Homo sapiens_hsa049760.37813715
141Metabolic pathways_Homo sapiens_hsa011000.37324541
142Alcoholism_Homo sapiens_hsa050340.37258050
143Inositol phosphate metabolism_Homo sapiens_hsa005620.36155877
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.35965945
145Histidine metabolism_Homo sapiens_hsa003400.34925861
146Gastric acid secretion_Homo sapiens_hsa049710.33538866
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32964297
148Glutamatergic synapse_Homo sapiens_hsa047240.32872537
149Salivary secretion_Homo sapiens_hsa049700.30335961
150Alzheimers disease_Homo sapiens_hsa050100.29520631
151Fatty acid elongation_Homo sapiens_hsa000620.28010052
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26823179
153cAMP signaling pathway_Homo sapiens_hsa040240.26717484
154Synaptic vesicle cycle_Homo sapiens_hsa047210.22796607
155Renin-angiotensin system_Homo sapiens_hsa046140.22697673
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21949254
157Cocaine addiction_Homo sapiens_hsa050300.21606823
158Retinol metabolism_Homo sapiens_hsa008300.20923222
159B cell receptor signaling pathway_Homo sapiens_hsa046620.19656122
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19112876
161RNA degradation_Homo sapiens_hsa030180.18423687
162Viral carcinogenesis_Homo sapiens_hsa052030.13321436
163Pyrimidine metabolism_Homo sapiens_hsa002400.13301093
164Wnt signaling pathway_Homo sapiens_hsa043100.10718124

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