ADAM20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* reproduction (GO:0000003)9.66811878
2spermatid development (GO:0007286)9.46778952
3motile cilium assembly (GO:0044458)9.01211841
4response to pheromone (GO:0019236)8.92009461
5cilium movement (GO:0003341)8.91816355
6regulation of cilium movement (GO:0003352)8.37606083
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.35038123
8sperm capacitation (GO:0048240)7.71707461
9male meiosis (GO:0007140)7.71434634
10* single fertilization (GO:0007338)7.50649318
11synaptonemal complex organization (GO:0070193)7.15066778
12synaptonemal complex assembly (GO:0007130)7.12824200
13piRNA metabolic process (GO:0034587)7.04953385
14pattern specification involved in kidney development (GO:0061004)6.49312125
15* fertilization (GO:0009566)6.32106525
16protein targeting to Golgi (GO:0000042)6.26653581
17spermatogenesis (GO:0007283)6.21292867
18male gamete generation (GO:0048232)6.18967233
19microtubule depolymerization (GO:0007019)6.17380814
20establishment of protein localization to Golgi (GO:0072600)6.16091004
21spermatid nucleus differentiation (GO:0007289)5.85577804
22organic cation transport (GO:0015695)5.85094082
23negative regulation of inclusion body assembly (GO:0090084)5.83508994
24retrograde transport, vesicle recycling within Golgi (GO:0000301)5.78455679
25gamete generation (GO:0007276)5.69559322
26ventricular system development (GO:0021591)5.63087649
27calcium ion-dependent exocytosis (GO:0017156)5.41410683
28cellular process involved in reproduction in multicellular organism (GO:0022412)5.39253746
29germ cell development (GO:0007281)5.28616782
30chromosome organization involved in meiosis (GO:0070192)5.09753100
31* cell recognition (GO:0008037)5.03262116
32regulation of inclusion body assembly (GO:0090083)5.00951701
33microtubule severing (GO:0051013)4.94920541
34regulation of microtubule-based movement (GO:0060632)4.87282357
35protein localization to Golgi apparatus (GO:0034067)4.79678611
36male meiosis I (GO:0007141)4.77303522
37glycerol ether metabolic process (GO:0006662)4.66265546
38DNA methylation involved in gamete generation (GO:0043046)4.54526921
39multicellular organismal reproductive process (GO:0048609)4.49935274
40rRNA methylation (GO:0031167)4.45850948
41cellular ketone body metabolic process (GO:0046950)4.42020244
42single strand break repair (GO:0000012)4.32319634
43monoubiquitinated protein deubiquitination (GO:0035520)4.31994609
44ether metabolic process (GO:0018904)4.30724800
45meiotic nuclear division (GO:0007126)4.30633514
46phosphatidylethanolamine biosynthetic process (GO:0006646)4.19577379
47sexual reproduction (GO:0019953)4.14819697
48protein K11-linked deubiquitination (GO:0035871)4.07370034
49seminiferous tubule development (GO:0072520)4.06556740
50genitalia morphogenesis (GO:0035112)4.04399149
51left/right pattern formation (GO:0060972)4.00776923
52phosphatidylethanolamine metabolic process (GO:0046337)3.93907614
53regulation of Rab GTPase activity (GO:0032313)3.89314928
54positive regulation of Rab GTPase activity (GO:0032851)3.89314928
55ketone body metabolic process (GO:1902224)3.84969707
56meiosis I (GO:0007127)3.72613367
57multicellular organismal movement (GO:0050879)3.72505499
58musculoskeletal movement (GO:0050881)3.72505499
59protein polyglutamylation (GO:0018095)3.71348318
60multicellular organismal development (GO:0007275)3.66022256
61RNA destabilization (GO:0050779)3.62725380
62chromosome condensation (GO:0030261)3.61485073
63segment specification (GO:0007379)3.55952628
64histone mRNA catabolic process (GO:0071044)3.50678309
65chaperone-mediated protein complex assembly (GO:0051131)3.47051320
66rRNA modification (GO:0000154)3.45086766
67sequestering of actin monomers (GO:0042989)3.41942892
68DNA packaging (GO:0006323)3.41039233
69coenzyme catabolic process (GO:0009109)3.40222395
70spinal cord motor neuron differentiation (GO:0021522)3.36895080
71synapsis (GO:0007129)3.31830233
72protein localization to cilium (GO:0061512)3.27750009
73microtubule polymerization or depolymerization (GO:0031109)3.22224102
74intra-Golgi vesicle-mediated transport (GO:0006891)3.17381058
75cilium organization (GO:0044782)3.15518427
76meiotic cell cycle (GO:0051321)3.14850058
77glycolytic process (GO:0006096)3.08018922
78regulation of transcription involved in cell fate commitment (GO:0060850)3.07034460
79lactate metabolic process (GO:0006089)3.04731503
80GTP biosynthetic process (GO:0006183)3.04551142
81cilium assembly (GO:0042384)3.04023624
82nucleoside diphosphate phosphorylation (GO:0006165)3.03978897
83polyol catabolic process (GO:0046174)3.02394561
84photoreceptor cell maintenance (GO:0045494)3.02364565
85carnitine transport (GO:0015879)3.01936956
86amino-acid betaine transport (GO:0015838)3.01936956
87regulation of telomere maintenance (GO:0032204)3.01407224
88intraciliary transport (GO:0042073)3.01372767
89microtubule-based movement (GO:0007018)2.98846193
90cellular component assembly involved in morphogenesis (GO:0010927)2.97940474
91alditol metabolic process (GO:0019400)2.94509847
92carnitine transmembrane transport (GO:1902603)2.90894750
93positive regulation of action potential (GO:0045760)2.90825946
94protein refolding (GO:0042026)2.86042800
95nucleus organization (GO:0006997)2.79196788
96regulation of spindle checkpoint (GO:0090231)2.78579018
97centriole assembly (GO:0098534)2.76995928
98meiotic cell cycle process (GO:1903046)2.76014917
99cilium morphogenesis (GO:0060271)2.74337671
100negative regulation of organelle assembly (GO:1902116)2.72138402
101UTP biosynthetic process (GO:0006228)2.69787286
102chromatin silencing (GO:0006342)2.68727620
103positive regulation of glycolytic process (GO:0045821)2.67635633
104negative regulation of Rho protein signal transduction (GO:0035024)2.65665688
105calcium ion import (GO:0070509)2.62229613
106positive regulation of macrophage activation (GO:0043032)2.60415995
107axoneme assembly (GO:0035082)2.60107040
108detection of light stimulus involved in sensory perception (GO:0050962)2.56879564
109detection of light stimulus involved in visual perception (GO:0050908)2.56879564
110glycerol metabolic process (GO:0006071)2.55332601
111glomerular visceral epithelial cell development (GO:0072015)2.55058786
112regulation of phosphoprotein phosphatase activity (GO:0043666)2.53557718
113mitotic sister chromatid cohesion (GO:0007064)2.51730572
114centriole replication (GO:0007099)2.50085509
115regulation of centriole replication (GO:0046599)2.49867130
116gene silencing by RNA (GO:0031047)2.49854447
117positive regulation of guanylate cyclase activity (GO:0031284)2.48305477
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48017439
119retinal ganglion cell axon guidance (GO:0031290)2.45304157
120detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.44912917
121UTP metabolic process (GO:0046051)2.42613304
122behavioral response to ethanol (GO:0048149)2.41158702
123peptidyl-glutamic acid modification (GO:0018200)2.40862697
124microtubule bundle formation (GO:0001578)2.40832643
125limb bud formation (GO:0060174)2.39763368
126interferon-gamma secretion (GO:0072643)2.38108896
127fusion of sperm to egg plasma membrane (GO:0007342)14.8224613
128cell wall macromolecule catabolic process (GO:0016998)13.9599994
129cell wall macromolecule metabolic process (GO:0044036)13.9599994
130sperm motility (GO:0030317)13.8403350
131acrosome assembly (GO:0001675)12.7252741
132* sperm-egg recognition (GO:0035036)11.5289465
133acrosome reaction (GO:0007340)11.3700184
134* multicellular organism reproduction (GO:0032504)11.3240953
135plasma membrane fusion (GO:0045026)11.3171523
136cilium or flagellum-dependent cell motility (GO:0001539)10.9681235
137epithelial cilium movement (GO:0003351)10.7400173
138axonemal dynein complex assembly (GO:0070286)10.3051627
139* cell-cell recognition (GO:0009988)10.3021731
140* binding of sperm to zona pellucida (GO:0007339)10.1354653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.57654175
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.77818663
3EZH2_22144423_ChIP-Seq_EOC_Human3.92546917
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.54159569
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.19871374
6GBX2_23144817_ChIP-Seq_PC3_Human2.86411632
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.72780823
8FUS_26573619_Chip-Seq_HEK293_Human2.69496590
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.65216108
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57324842
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.45473054
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43611010
13P300_19829295_ChIP-Seq_ESCs_Human2.41514735
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.39809862
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.31426233
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21324776
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14679393
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08249249
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.05021332
20KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.04460845
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01609351
22ZNF274_21170338_ChIP-Seq_K562_Hela2.00541713
23VDR_22108803_ChIP-Seq_LS180_Human1.99285921
24RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.98952506
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.97161639
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96215318
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91386442
28SMAD4_21799915_ChIP-Seq_A2780_Human1.87245883
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86038252
30ER_23166858_ChIP-Seq_MCF-7_Human1.85821586
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81232318
32TP53_18474530_ChIP-ChIP_U2OS_Human1.79766556
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79181897
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.78376289
35AR_25329375_ChIP-Seq_VCAP_Human1.77979686
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.77529761
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76703729
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73687926
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.72060341
40KAP1_22055183_ChIP-Seq_ESCs_Mouse1.71283991
41KDM2B_26808549_Chip-Seq_REH_Human1.70669323
42STAT1_17558387_ChIP-Seq_HELA_Human1.70076344
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69757584
44STAT3_23295773_ChIP-Seq_U87_Human1.67638433
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66847525
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.65497091
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.64798514
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.64306744
49IGF1R_20145208_ChIP-Seq_DFB_Human1.61985437
50* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.58820209
51GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.57455816
52RUNX2_22187159_ChIP-Seq_PCA_Human1.55310129
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.54871040
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54147228
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53949007
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53467652
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52967991
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.51370314
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48621384
60CBP_20019798_ChIP-Seq_JUKART_Human1.48621384
61ELK4_26923725_Chip-Seq_MESODERM_Mouse1.48062116
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45773585
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44988410
64BCAT_22108803_ChIP-Seq_LS180_Human1.43701159
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.43498929
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.42713925
67SOX2_19829295_ChIP-Seq_ESCs_Human1.41414679
68NANOG_19829295_ChIP-Seq_ESCs_Human1.41414679
69TCF4_23295773_ChIP-Seq_U87_Human1.41011806
70P53_22387025_ChIP-Seq_ESCs_Mouse1.40465608
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.40191045
72OCT4_18555785_Chip-Seq_ESCs_Mouse1.39095070
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38792388
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.38196165
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.37885007
76RNF2_27304074_Chip-Seq_NSC_Mouse1.37533250
77TCF4_22108803_ChIP-Seq_LS180_Human1.36096649
78TAF15_26573619_Chip-Seq_HEK293_Human1.35444587
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.34503286
80SMAD3_21741376_ChIP-Seq_ESCs_Human1.34450338
81FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34276374
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.34267380
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33226488
84P300_18555785_Chip-Seq_ESCs_Mouse1.32279014
85REST_21632747_ChIP-Seq_MESCs_Mouse1.31795613
86SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31574812
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30078564
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29259786
89TBL1_22424771_ChIP-Seq_293T_Human1.29001499
90EWS_26573619_Chip-Seq_HEK293_Human1.28205661
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.27943764
92AR_21572438_ChIP-Seq_LNCaP_Human1.27152955
93GATA3_21867929_ChIP-Seq_CD8_Mouse1.27075567
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26197458
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26163364
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24729327
97KLF4_18555785_Chip-Seq_ESCs_Mouse1.23733092
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.22783584
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22337540
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21972925
101ETV1_20927104_ChIP-Seq_GIST48_Human1.21750248
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21700586
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21138568
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.20829870
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18947158
106LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18034962
107CBX2_22325352_ChIP-Seq_293T-Rex_Human1.17098372
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.17069697
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16037174
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16037174
111* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15853365
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.15189829
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13956592
114HNFA_21074721_ChIP-Seq_CACO-2_Human1.13798554
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13480896
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.13345421
117CTCF_18555785_Chip-Seq_ESCs_Mouse1.13017638
118PHF8_20622853_ChIP-Seq_HELA_Human1.12253485
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12057841
120CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11763624
121CDX2_22108803_ChIP-Seq_LS180_Human1.11529983
122PU1_27457419_Chip-Seq_LIVER_Mouse1.11260516
123PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11247126
124P53_21459846_ChIP-Seq_SAOS-2_Human1.10879651
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10644382
126GF1_26923725_Chip-Seq_HPCs_Mouse1.10400044
127RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09669290
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09216884
129CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09070691
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08778329
131RBPJ_21746931_ChIP-Seq_IB4_Human1.08677075
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08116449
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07658587
134SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07141850
135NMYC_18555785_Chip-Seq_ESCs_Mouse1.06951154
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06175156
137NFYA_21822215_ChIP-Seq_K562_Human1.05558190
138SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04495615
139NANOG_20526341_ChIP-Seq_ESCs_Human1.03887623
140MYC_19829295_ChIP-Seq_ESCs_Human1.03603746
141RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03180601
142SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02401086
143CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01836869
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01765666
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01331449
146SOX2_21211035_ChIP-Seq_LN229_Gbm1.01232134
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99525821
148ZFX_18555785_Chip-Seq_ESCs_Mouse0.99209073
149SOX9_26525672_Chip-Seq_HEART_Mouse0.98238208
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.97845161
151KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96259676
152FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95328075
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94149260
154NFYB_21822215_ChIP-Seq_K562_Human0.93377003
155NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93166467
156GF1B_26923725_Chip-Seq_HPCs_Mouse0.92912201
157SPI1_26923725_Chip-Seq_HPCs_Mouse0.92404178
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90879628
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90200706
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90188854
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89879853
162SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89064906
163CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88954743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.19431709
2MP0001929_abnormal_gametogenesis5.54363211
3MP0008877_abnormal_DNA_methylation4.19145857
4MP0002210_abnormal_sex_determination3.48485099
5MP0002161_abnormal_fertility/fecundity3.33258396
6MP0001145_abnormal_male_reproductive2.96099037
7MP0000516_abnormal_urinary_system2.86921272
8MP0005367_renal/urinary_system_phenotyp2.86921272
9MP0000653_abnormal_sex_gland2.57514306
10MP0002653_abnormal_ependyma_morphology2.56023661
11MP0005670_abnormal_white_adipose2.54750959
12MP0005248_abnormal_Harderian_gland2.50865376
13MP0005623_abnormal_meninges_morphology2.08439838
14MP0005410_abnormal_fertilization16.2331036
15MP0002254_reproductive_system_inflammat1.82665292
16MP0006292_abnormal_olfactory_placode1.81818555
17MP0003718_maternal_effect1.73760955
18MP0005379_endocrine/exocrine_gland_phen1.65861647
19MP0002282_abnormal_trachea_morphology1.63177718
20MP0001485_abnormal_pinna_reflex1.51730853
21MP0002160_abnormal_reproductive_system1.50204593
22MP0009046_muscle_twitch1.41279823
23MP0000778_abnormal_nervous_system1.34365990
24MP0008058_abnormal_DNA_repair1.33532474
25MP0001765_abnormal_ion_homeostasis1.30881907
26MP0008789_abnormal_olfactory_epithelium1.28588037
27MP0003787_abnormal_imprinting1.22539403
28MP0002734_abnormal_mechanical_nocicepti1.19460226
29MP0005499_abnormal_olfactory_system1.16509810
30MP0005394_taste/olfaction_phenotype1.16509810
31MP0005647_abnormal_sex_gland1.16418467
32MP0004233_abnormal_muscle_weight1.14386525
33MP0002735_abnormal_chemical_nociception1.14337876
34MP0003890_abnormal_embryonic-extraembry1.11981691
35MP0008775_abnormal_heart_ventricle1.11318708
36MP0002127_abnormal_cardiovascular_syste1.09580494
37MP0000427_abnormal_hair_cycle1.09324696
38MP0001529_abnormal_vocalization1.08018638
39MP0005084_abnormal_gallbladder_morpholo1.07665898
40MP0001348_abnormal_lacrimal_gland1.06752588
41MP0001984_abnormal_olfaction1.04900536
42MP0001299_abnormal_eye_distance/1.04712014
43MP0001963_abnormal_hearing_physiology1.02570554
44MP0003646_muscle_fatigue0.99867777
45MP0002557_abnormal_social/conspecific_i0.97328339
46MP0009697_abnormal_copulation0.96884406
47MP0009053_abnormal_anal_canal0.94363405
48MP0005395_other_phenotype0.93654248
49MP0001501_abnormal_sleep_pattern0.93063443
50MP0002938_white_spotting0.91845658
51MP0000026_abnormal_inner_ear0.91161182
52MP0010030_abnormal_orbit_morphology0.90765872
53MP0002138_abnormal_hepatobiliary_system0.89306431
54MP0003119_abnormal_digestive_system0.89187794
55MP0000372_irregular_coat_pigmentation0.88151938
56MP0002132_abnormal_respiratory_system0.86124973
57MP0002067_abnormal_sensory_capabilities0.85717083
58MP0004085_abnormal_heartbeat0.84978138
59MP0002876_abnormal_thyroid_physiology0.84140393
60MP0002184_abnormal_innervation0.80767841
61MP0003755_abnormal_palate_morphology0.79015513
62MP0002233_abnormal_nose_morphology0.78492990
63MP0005646_abnormal_pituitary_gland0.76101826
64MP0003011_delayed_dark_adaptation0.76043250
65MP0002751_abnormal_autonomic_nervous0.75510340
66MP0004084_abnormal_cardiac_muscle0.74243871
67MP0005389_reproductive_system_phenotype0.73380645
68MP0003137_abnormal_impulse_conducting0.71805732
69MP0000049_abnormal_middle_ear0.71599917
70MP0002234_abnormal_pharynx_morphology0.70894376
71MP0000749_muscle_degeneration0.70492730
72MP0000631_abnormal_neuroendocrine_gland0.68762166
73MP0006276_abnormal_autonomic_nervous0.68633816
74MP0005636_abnormal_mineral_homeostasis0.67411467
75MP0003283_abnormal_digestive_organ0.65217859
76MP0008995_early_reproductive_senescence0.64048691
77MP0004019_abnormal_vitamin_homeostasis0.62975311
78MP0005551_abnormal_eye_electrophysiolog0.62424177
79MP0001293_anophthalmia0.56845030
80MP0005253_abnormal_eye_physiology0.56567023
81MP0008057_abnormal_DNA_replication0.55578942
82MP0002736_abnormal_nociception_after0.55247314
83MP0010094_abnormal_chromosome_stability0.52726017
84MP0003878_abnormal_ear_physiology0.51205913
85MP0005377_hearing/vestibular/ear_phenot0.51205913
86MP0003699_abnormal_female_reproductive0.51084626
87MP0003115_abnormal_respiratory_system0.50640403
88MP0001324_abnormal_eye_pigmentation0.50098532
89MP0003950_abnormal_plasma_membrane0.49800086
90MP0004134_abnormal_chest_morphology0.49740725
91MP0004036_abnormal_muscle_relaxation0.49326320
92MP0002102_abnormal_ear_morphology0.49088904
93MP0000569_abnormal_digit_pigmentation0.45534930
94MP0005666_abnormal_adipose_tissue0.44544966
95MP0003633_abnormal_nervous_system0.43716130
96MP0004145_abnormal_muscle_electrophysio0.43067805
97MP0005391_vision/eye_phenotype0.40960361
98MP0001764_abnormal_homeostasis0.38415219
99MP0004742_abnormal_vestibular_system0.38141496
100MP0001968_abnormal_touch/_nociception0.36835944
101MP0001119_abnormal_female_reproductive0.35841224
102MP0002928_abnormal_bile_duct0.34115257
103MP0006072_abnormal_retinal_apoptosis0.33010803
104MP0004133_heterotaxia0.32418932
105MP0003879_abnormal_hair_cell0.32176872
106MP0000462_abnormal_digestive_system0.32096795
107MP0000358_abnormal_cell_content/0.30875971
108MP0005397_hematopoietic_system_phenotyp0.29893570
109MP0001545_abnormal_hematopoietic_system0.29893570
110MP0002572_abnormal_emotion/affect_behav0.29483655
111MP0002971_abnormal_brown_adipose0.27443005
112MP0003631_nervous_system_phenotype0.26225306
113MP0003786_premature_aging0.25994432
114MP0005423_abnormal_somatic_nervous0.25715161
115MP0002139_abnormal_hepatobiliary_system0.25138537
116MP0004811_abnormal_neuron_physiology0.24565139
117MP0002152_abnormal_brain_morphology0.24420928
118MP0009115_abnormal_fat_cell0.24226752
119MP0002269_muscular_atrophy0.24080190
120MP0002295_abnormal_pulmonary_circulatio0.23658088
121MP0003861_abnormal_nervous_system0.22338531
122MP0003329_amyloid_beta_deposits0.22132834
123MP0006036_abnormal_mitochondrial_physio0.22102776
124MP0004270_analgesia0.21729732
125MP0002092_abnormal_eye_morphology0.21645515
126MP0002133_abnormal_respiratory_system0.20801334
127MP0005388_respiratory_system_phenotype0.20801334
128MP0005195_abnormal_posterior_eye0.19500184
129MP0003635_abnormal_synaptic_transmissio0.18843566
130MP0008569_lethality_at_weaning0.18690038
131MP0002229_neurodegeneration0.17590847
132MP0008875_abnormal_xenobiotic_pharmacok0.17261295
133MP0001440_abnormal_grooming_behavior0.16826194
134MP0002169_no_abnormal_phenotype0.16420110
135MP0002837_dystrophic_cardiac_calcinosis0.16243116
136MP0002873_normal_phenotype0.16183302
137MP0003880_abnormal_central_pattern0.16109272
138MP0002272_abnormal_nervous_system0.16060800
139MP0002693_abnormal_pancreas_physiology0.15702030
140MP0008007_abnormal_cellular_replicative0.15123228
141MP0001661_extended_life_span0.15100335
142MP0003948_abnormal_gas_homeostasis0.14982086
143MP0001986_abnormal_taste_sensitivity0.14090342
144MP0009745_abnormal_behavioral_response0.13868545
145MP0002752_abnormal_somatic_nervous0.13789466
146MP0001486_abnormal_startle_reflex0.13754667
147MP0004859_abnormal_synaptic_plasticity0.13510703
148MP0000534_abnormal_ureter_morphology0.13458504
149MP0004808_abnormal_hematopoietic_stem0.13280725
150MP0000955_abnormal_spinal_cord0.13269824

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.53057484
2Abnormal respiratory motile cilium morphology (HP:0005938)9.18789041
3Abnormal respiratory epithelium morphology (HP:0012253)9.18789041
4Abnormal ciliary motility (HP:0012262)8.07840299
5Rhinitis (HP:0012384)7.44999481
6Chronic bronchitis (HP:0004469)7.20375150
7Infertility (HP:0000789)6.18734129
8Nasal polyposis (HP:0100582)6.03713542
9Abnormality of the nasal mucosa (HP:0000433)4.96571072
10Severe visual impairment (HP:0001141)4.82438900
11Nephronophthisis (HP:0000090)4.57302576
12Bronchitis (HP:0012387)4.47897778
13Bronchiectasis (HP:0002110)4.38793230
14Male infertility (HP:0003251)4.36590431
15Recurrent sinusitis (HP:0011108)3.84711281
16Attenuation of retinal blood vessels (HP:0007843)3.80538006
17Abnormality of the renal medulla (HP:0100957)3.48481583
18Tubulointerstitial nephritis (HP:0001970)3.37167278
19Abnormal spermatogenesis (HP:0008669)3.37066553
20Hypoplastic ischia (HP:0003175)3.36898511
21Recurrent otitis media (HP:0000403)3.26618309
22Bony spicule pigmentary retinopathy (HP:0007737)3.21232972
23Abnormality of the ischium (HP:0003174)3.20328908
24Pancreatic cysts (HP:0001737)3.13604030
25Abnormal rod and cone electroretinograms (HP:0008323)3.12653072
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.12626783
27Resting tremor (HP:0002322)3.09723310
28Molar tooth sign on MRI (HP:0002419)2.87156591
29Abnormality of midbrain morphology (HP:0002418)2.87156591
30Double outlet right ventricle (HP:0001719)2.86757531
31Congenital malformation of the right heart (HP:0011723)2.86757531
32Tubular atrophy (HP:0000092)2.84352799
33Abnormality of macular pigmentation (HP:0008002)2.77445173
34Recurrent bronchitis (HP:0002837)2.66246197
35Intestinal atresia (HP:0011100)2.64309778
36Abnormality of the parathyroid morphology (HP:0011766)2.63362717
37Medial flaring of the eyebrow (HP:0010747)2.59154217
38Tubulointerstitial abnormality (HP:0001969)2.57282187
39Pancreatic islet-cell hyperplasia (HP:0004510)2.52333031
40Occipital encephalocele (HP:0002085)2.49994196
41Genital tract atresia (HP:0001827)2.46932351
42Oligodactyly (hands) (HP:0001180)2.34850098
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33867072
44Anencephaly (HP:0002323)2.32228616
45Postural instability (HP:0002172)2.31830978
46Abnormality of the pubic bones (HP:0003172)2.29747978
47Polyuria (HP:0000103)2.28928952
48Vaginal atresia (HP:0000148)2.25499158
49Fetal akinesia sequence (HP:0001989)2.23665508
50Hyperkalemia (HP:0002153)2.22596031
51Aplasia/Hypoplasia of the earlobes (HP:0009906)2.22320823
52Azoospermia (HP:0000027)2.20562530
53Volvulus (HP:0002580)2.20547318
54Anophthalmia (HP:0000528)2.19064337
55Midline defect of the nose (HP:0004122)2.15271111
56Decreased central vision (HP:0007663)2.12715178
57Disproportionate short-trunk short stature (HP:0003521)2.10506237
58Impulsivity (HP:0100710)2.08446839
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.06821914
60Progressive cerebellar ataxia (HP:0002073)2.06361635
61Gastrointestinal atresia (HP:0002589)2.06053271
62Facial shape deformation (HP:0011334)2.03908170
63Potter facies (HP:0002009)2.03908170
64Postaxial foot polydactyly (HP:0001830)2.03361033
65Absent/shortened dynein arms (HP:0200106)13.5767946
66Dynein arm defect of respiratory motile cilia (HP:0012255)13.5767946
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4799216
68Gonadotropin excess (HP:0000837)1.99846996
69Aplasia/Hypoplasia involving the musculature (HP:0001460)1.99717118
70Stage 5 chronic kidney disease (HP:0003774)1.99678059
71Type II lissencephaly (HP:0007260)1.99307811
72Pendular nystagmus (HP:0012043)1.99293041
73Severe Myopia (HP:0011003)1.95067543
74Renal hypoplasia (HP:0000089)1.94939028
75Hypoplasia of the thymus (HP:0000778)1.94513436
76Insulin-resistant diabetes mellitus (HP:0000831)1.94247516
77Septo-optic dysplasia (HP:0100842)1.92902262
78Congenital hepatic fibrosis (HP:0002612)1.90011294
79Retinal dysplasia (HP:0007973)1.89192913
80Abnormality of the renal cortex (HP:0011035)1.88826766
81Type 2 muscle fiber atrophy (HP:0003554)1.87752683
82Hypoalphalipoproteinemia (HP:0003233)1.87726981
83Short tibia (HP:0005736)1.87168960
84Abnormality of the dental root (HP:0006486)1.85215256
85Taurodontia (HP:0000679)1.85215256
86Abnormality of permanent molar morphology (HP:0011071)1.85215256
87Fibular hypoplasia (HP:0003038)1.84507968
88Dyschromatopsia (HP:0007641)1.84298001
89Poor coordination (HP:0002370)1.82538182
90Tubulointerstitial fibrosis (HP:0005576)1.81850344
91Enlarged epiphyses (HP:0010580)1.81149960
92Truncal obesity (HP:0001956)1.80377550
93Bifid tongue (HP:0010297)1.79452975
94Abnormality of abdominal situs (HP:0011620)1.78696513
95Abdominal situs inversus (HP:0003363)1.78696513
96Microglossia (HP:0000171)1.78094218
97Retinal atrophy (HP:0001105)1.78020148
98Polydipsia (HP:0001959)1.77321131
99Abnormal drinking behavior (HP:0030082)1.77321131
100Cone-rod dystrophy (HP:0000548)1.76964757
101Pancreatic fibrosis (HP:0100732)1.76567794
102Abnormality of molar morphology (HP:0011070)1.75734738
103Abnormality of molar (HP:0011077)1.75734738
104Preaxial hand polydactyly (HP:0001177)1.71291897
105Cholecystitis (HP:0001082)1.71114076
106Abnormal gallbladder physiology (HP:0012438)1.71114076
107Short ribs (HP:0000773)1.69068730
108Abnormality of renal excretion (HP:0011036)1.68858314
109Abnormality of the dental pulp (HP:0006479)1.68851342
110Abnormal biliary tract physiology (HP:0012439)1.65307382
111Bile duct proliferation (HP:0001408)1.65307382
112Asymmetric septal hypertrophy (HP:0001670)1.63233862
113Oculomotor apraxia (HP:0000657)1.59418927
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57523261
115Absent frontal sinuses (HP:0002688)1.56061374
116Abnormality of the lower motor neuron (HP:0002366)1.54243363
117Chronic sinusitis (HP:0011109)1.53484765
118Heterotopia (HP:0002282)1.51997603
119J-shaped sella turcica (HP:0002680)1.51114401
120Optic nerve hypoplasia (HP:0000609)1.50930759
121Postaxial hand polydactyly (HP:0001162)1.50369091
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.50279697
123Cystic liver disease (HP:0006706)1.50223729
124Renal dysplasia (HP:0000110)1.48422902
125Facial cleft (HP:0002006)1.47560642
126Median cleft lip (HP:0000161)1.46747749
127Bundle branch block (HP:0011710)1.46526491
128Chronic hepatic failure (HP:0100626)1.45781541
129Bell-shaped thorax (HP:0001591)1.45250019
130Spastic tetraparesis (HP:0001285)1.43744020
131Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.43144157
132Abnormality of saccadic eye movements (HP:0000570)1.41559629
133Supernumerary spleens (HP:0009799)1.39691716
134Gait imbalance (HP:0002141)1.38417281
135Congenital primary aphakia (HP:0007707)1.37779013
136Abnormality of dentin (HP:0010299)1.37200566
137Vascular calcification (HP:0004934)1.35648720
138Aplasia/Hypoplasia of the lens (HP:0008063)1.32358574
139Nephropathy (HP:0000112)1.32160809
140True hermaphroditism (HP:0010459)1.29626701
141Abnormality of ocular smooth pursuit (HP:0000617)1.28914392
142Choroideremia (HP:0001139)1.28780963
143Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.28647236
144Abnormal urine output (HP:0012590)1.27500945
145Short thorax (HP:0010306)1.26585066
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.24331217
147Hemorrhage of the eye (HP:0011885)1.23714872
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.23101446
149Absent epiphyses (HP:0010577)1.23101446
150Tongue fasciculations (HP:0001308)1.22453227
151Deformed sella turcica (HP:0002681)1.21534127
152Cardiovascular calcification (HP:0011915)1.21184427
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.20318950
154Amyotrophic lateral sclerosis (HP:0007354)1.18993149
155Hemiparesis (HP:0001269)1.17600440
156Nephrogenic diabetes insipidus (HP:0009806)1.13963669
157Impaired smooth pursuit (HP:0007772)1.12798221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.42781928
2PDK39.42781928
3PDK26.19930545
4INSRR4.73388283
5MAP4K24.23110500
6TESK14.21473760
7FRK3.97972127
8PRKD33.73315153
9BMPR1B3.45531379
10ICK3.13905358
11ACVR1B2.69935927
12BRD42.63689845
13PLK22.45671788
14DDR22.19684152
15PTK2B2.19409000
16TRIM282.13564163
17PNCK2.00971237
18WNK41.98100837
19STK391.89713255
20EIF2AK31.82339123
21MARK11.82316512
22TNIK1.76186729
23TGFBR11.58057525
24AKT31.48707400
25NUAK11.45254930
26STK381.44110763
27LATS11.38545961
28FGFR21.37276001
29MAPK131.26525118
30PDK11.13630277
31OBSCN1.12090828
32NEK21.09398156
33DYRK1B1.08397979
34ZAK1.07121603
35PIM21.02904714
36FER0.97944224
37OXSR10.97664624
38BCR0.94302048
39EPHA40.92335308
40ADRBK20.86862610
41STK38L0.84806455
42LMTK20.82238530
43ERBB30.78995371
44WNK10.77362784
45MKNK20.76711256
46PAK30.76385676
47TYRO30.74200440
48PIK3CG0.73514802
49MAPK150.69245448
50IRAK10.66671002
51RIPK40.65764795
52MAP2K60.65158941
53MST1R0.64797699
54DYRK30.59038010
55CAMK1G0.58399944
56PRKCE0.58339368
57STK30.57217847
58PASK0.56702931
59ROCK10.56520833
60PDPK10.54383769
61SRPK10.52389689
62NTRK30.52010689
63MUSK0.51317339
64CHEK20.50046436
65PRKAA20.49872416
66CAMK10.49454229
67ERBB40.49197921
68CAMK2D0.47897964
69TTK0.47263989
70MAP3K70.44539034
71CCNB10.43385943
72NEK60.43283503
73MAPKAPK50.40982104
74PLK30.39510966
75CASK0.39258040
76MAP2K70.38650573
77SGK20.37983701
78IRAK20.36292261
79CHEK10.35240244
80CDK80.34494084
81WEE10.33911718
82PINK10.32546733
83SGK4940.31569864
84SGK2230.31569864
85NTRK20.31473343
86PRKCG0.30204680
87CDK50.29624347
88CSNK1A1L0.29186376
89PAK10.29176275
90CSNK1G10.28564523
91MAP3K90.27418255
92CAMK40.27145699
93FGFR10.26396575
94PLK40.26178550
95ATM0.25716192
96CSNK1G20.25629071
97EEF2K0.24949520
98DYRK1A0.23922924
99ATR0.23514093
100MKNK10.22633704
101CAMK1D0.22149479
102PHKG20.20916198
103PHKG10.20916198
104GRK70.20727148
105MAP3K20.20622508
106MAP3K40.20520831
107ADRBK10.20112145
108BRSK20.19811762
109CDK70.19751842
110MARK20.18906488
111PAK20.18231507
112PRKAA10.17993557
113PKN10.17839684
114TESK20.17591906
115RPS6KB10.16974222
116CAMKK10.16572393
117TNK20.16510263
118PRKG20.13824840
119PRKCQ0.13226639
120CAMK2A0.13184495
121PRKG10.11951836
122MTOR0.11949340
123CDC70.10986067
124STK160.10425822
125PLK10.09928132
126PRKCZ0.09526070
127YES10.08477521
128ZAP700.08144336
129PRKACG0.07960588
130GRK10.07926605
131GSK3B0.06871986
132WNK30.06575531
133CSNK2A10.06144614
134CSNK2A20.05892323
135CDK60.05340291
136PDGFRB0.04835242
137MAP3K50.04620910
138CSNK1D0.04232426
139MAPK80.03564764
140PRKACB0.03292398
141CDK10.03234840
142STK110.03009846
143PRKCB0.02960830
144PRKCD0.02748396
145MAP3K100.02724373
146PRKCA0.02543878
147CDK150.02028734
148MARK30.01907937
149PRKACA0.01847220
150PRKDC0.01265098
151MAPK100.01144937
152CDK30.01097031
153CDK40.00896796
154CDK20.00331715
155CDK120.00067632
156MAP2K4-0.0090466
157RPS6KA3-0.0081542
158SRC-0.0067837
159CDK11A-0.0051555
160CDK18-0.0037878
161GSK3A-0.0022344

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.83549095
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.37870487
3Vitamin B6 metabolism_Homo sapiens_hsa007504.18268596
4Fatty acid biosynthesis_Homo sapiens_hsa000613.81799854
5Pyruvate metabolism_Homo sapiens_hsa006203.70697348
6Propanoate metabolism_Homo sapiens_hsa006402.99682068
7Butanoate metabolism_Homo sapiens_hsa006502.83505008
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68948127
9Linoleic acid metabolism_Homo sapiens_hsa005912.63420599
10Glucagon signaling pathway_Homo sapiens_hsa049222.59171901
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.52098184
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.51865265
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.51804043
14Circadian rhythm_Homo sapiens_hsa047102.48815270
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39853729
16Phototransduction_Homo sapiens_hsa047442.31520654
17Basal transcription factors_Homo sapiens_hsa030222.26168530
18Pentose phosphate pathway_Homo sapiens_hsa000302.14225229
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.99642419
20Glycerolipid metabolism_Homo sapiens_hsa005611.96031893
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.91223535
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86789348
23Nitrogen metabolism_Homo sapiens_hsa009101.84935070
24Amphetamine addiction_Homo sapiens_hsa050311.78678069
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77956018
26PPAR signaling pathway_Homo sapiens_hsa033201.76337181
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.72769966
28Oocyte meiosis_Homo sapiens_hsa041141.71003387
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68883735
30Fanconi anemia pathway_Homo sapiens_hsa034601.62810153
31Dorso-ventral axis formation_Homo sapiens_hsa043201.53712680
32Non-homologous end-joining_Homo sapiens_hsa034501.53133534
33Mineral absorption_Homo sapiens_hsa049781.47538946
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.43439826
35Selenocompound metabolism_Homo sapiens_hsa004501.43376040
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39681169
37Ether lipid metabolism_Homo sapiens_hsa005651.34187080
38Arginine and proline metabolism_Homo sapiens_hsa003301.32349869
39RNA degradation_Homo sapiens_hsa030181.31546455
40Renin secretion_Homo sapiens_hsa049241.29993703
41Carbon metabolism_Homo sapiens_hsa012001.29901778
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.26241705
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23679064
44Cardiac muscle contraction_Homo sapiens_hsa042601.22757262
45Fructose and mannose metabolism_Homo sapiens_hsa000511.22506913
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21512120
47Caffeine metabolism_Homo sapiens_hsa002321.18236485
48Regulation of autophagy_Homo sapiens_hsa041401.17965272
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17849355
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17529074
51Huntingtons disease_Homo sapiens_hsa050161.10835292
52beta-Alanine metabolism_Homo sapiens_hsa004101.10505494
53Fatty acid degradation_Homo sapiens_hsa000711.10394021
54Fatty acid metabolism_Homo sapiens_hsa012121.10097673
55Purine metabolism_Homo sapiens_hsa002301.02851064
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.02113981
57Type II diabetes mellitus_Homo sapiens_hsa049301.00273233
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99642036
59Fat digestion and absorption_Homo sapiens_hsa049750.98806979
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97521805
61Tryptophan metabolism_Homo sapiens_hsa003800.96367338
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95381638
63Antigen processing and presentation_Homo sapiens_hsa046120.95295758
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94339458
65TGF-beta signaling pathway_Homo sapiens_hsa043500.93136554
66Renin-angiotensin system_Homo sapiens_hsa046140.89879424
67Insulin secretion_Homo sapiens_hsa049110.88712469
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88375224
69Biosynthesis of amino acids_Homo sapiens_hsa012300.87871332
70mRNA surveillance pathway_Homo sapiens_hsa030150.84128722
71Collecting duct acid secretion_Homo sapiens_hsa049660.82955806
72Calcium signaling pathway_Homo sapiens_hsa040200.82953710
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82095184
74Lysine degradation_Homo sapiens_hsa003100.81499805
75ABC transporters_Homo sapiens_hsa020100.79934523
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79625109
77Chemical carcinogenesis_Homo sapiens_hsa052040.76811554
78Bile secretion_Homo sapiens_hsa049760.75965065
79Glutathione metabolism_Homo sapiens_hsa004800.74823993
80Homologous recombination_Homo sapiens_hsa034400.74442815
81Peroxisome_Homo sapiens_hsa041460.73229161
82Morphine addiction_Homo sapiens_hsa050320.72440675
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70974276
84Long-term potentiation_Homo sapiens_hsa047200.66947027
85Thyroid hormone synthesis_Homo sapiens_hsa049180.66243355
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66153379
87Taste transduction_Homo sapiens_hsa047420.65841157
88Salivary secretion_Homo sapiens_hsa049700.65237234
89Arachidonic acid metabolism_Homo sapiens_hsa005900.64922613
90Inositol phosphate metabolism_Homo sapiens_hsa005620.63858421
91Cocaine addiction_Homo sapiens_hsa050300.63591339
92Tight junction_Homo sapiens_hsa045300.61159297
93Nicotine addiction_Homo sapiens_hsa050330.61105526
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60601881
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60310216
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59753451
97RNA transport_Homo sapiens_hsa030130.57657667
98Protein digestion and absorption_Homo sapiens_hsa049740.57175473
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.57056112
100Estrogen signaling pathway_Homo sapiens_hsa049150.56960584
101Hippo signaling pathway_Homo sapiens_hsa043900.56853907
102Glutamatergic synapse_Homo sapiens_hsa047240.54633719
103Pancreatic secretion_Homo sapiens_hsa049720.52855781
104cAMP signaling pathway_Homo sapiens_hsa040240.52835383
105Serotonergic synapse_Homo sapiens_hsa047260.51572654
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51094233
107Sulfur metabolism_Homo sapiens_hsa009200.50852749
108Circadian entrainment_Homo sapiens_hsa047130.50393930
109GABAergic synapse_Homo sapiens_hsa047270.50105192
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49557391
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49427706
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.49220732
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49217032
114Wnt signaling pathway_Homo sapiens_hsa043100.48967068
115Oxytocin signaling pathway_Homo sapiens_hsa049210.48838075
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48519559
117Synaptic vesicle cycle_Homo sapiens_hsa047210.47343440
118Hedgehog signaling pathway_Homo sapiens_hsa043400.47270754
119Gastric acid secretion_Homo sapiens_hsa049710.46678981
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45957768
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44847820
122Adherens junction_Homo sapiens_hsa045200.44079020
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43577074
124Histidine metabolism_Homo sapiens_hsa003400.42338376
125Endocytosis_Homo sapiens_hsa041440.42070918
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41953715
127Axon guidance_Homo sapiens_hsa043600.41465531
128FoxO signaling pathway_Homo sapiens_hsa040680.41377675
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39662880
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.38669887
131Steroid biosynthesis_Homo sapiens_hsa001000.38493249
132Fatty acid elongation_Homo sapiens_hsa000620.36781197
133Metabolic pathways_Homo sapiens_hsa011000.36532389
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36414814
135Arginine biosynthesis_Homo sapiens_hsa002200.35948075
136AMPK signaling pathway_Homo sapiens_hsa041520.35247798
137Systemic lupus erythematosus_Homo sapiens_hsa053220.33792364
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32466455
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.31849221
140Legionellosis_Homo sapiens_hsa051340.31396983
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29777438
142Olfactory transduction_Homo sapiens_hsa047400.28311426
143Retinol metabolism_Homo sapiens_hsa008300.27127027
144VEGF signaling pathway_Homo sapiens_hsa043700.22770993
145Alcoholism_Homo sapiens_hsa050340.19443568
146Salmonella infection_Homo sapiens_hsa051320.14581035
147Ovarian steroidogenesis_Homo sapiens_hsa049130.13638598
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13558562
149Vitamin digestion and absorption_Homo sapiens_hsa049770.12256960
150Complement and coagulation cascades_Homo sapiens_hsa046100.12214697

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