ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	8.30668839
2	protein targeting to Golgi (GO:0000042)	7.33469988
3	acrosome reaction (GO:0007340)	7.17971060
4	establishment of protein localization to Golgi (GO:0072600)	7.17223102
5	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.84250464
6	multicellular organism reproduction (GO:0032504)	6.13538406
7	spermatid development (GO:0007286)	6.05931050
8	fusion of sperm to egg plasma membrane (GO:0007342)	5.98447808
9	motile cilium assembly (GO:0044458)	5.92486716
10	positive regulation of catecholamine secretion (GO:0033605)	5.91461165
11	axonemal dynein complex assembly (GO:0070286)	5.42917091
12	protein localization to Golgi apparatus (GO:0034067)	5.40515563
13	cilium or flagellum-dependent cell motility (GO:0001539)	5.36651152
14	protein polyglutamylation (GO:0018095)	5.29187082
15	sperm-egg recognition (GO:0035036)	5.02965959
16	microtubule depolymerization (GO:0007019)	4.96611799
17	reproduction (GO:0000003)	4.93060331
18	epithelial cilium movement (GO:0003351)	4.87374201
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.65433601
20	binding of sperm to zona pellucida (GO:0007339)	4.59426029
21	plasma membrane fusion (GO:0045026)	4.53864267
22	cilium movement (GO:0003341)	4.48496351
23	sperm capacitation (GO:0048240)	4.48051178
24	microtubule polymerization or depolymerization (GO:0031109)	4.46290510
25	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.40037997
26	chromosome condensation (GO:0030261)	4.37962074
27	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.29773978
28	coenzyme catabolic process (GO:0009109)	4.27863093
29	cell-cell recognition (GO:0009988)	4.25056959
30	spermatid nucleus differentiation (GO:0007289)	4.17189196
31	single fertilization (GO:0007338)	4.14997457
32	DNA packaging (GO:0006323)	4.13488193
33	seminiferous tubule development (GO:0072520)	4.12908997
34	spermatogenesis (GO:0007283)	4.11869817
35	male gamete generation (GO:0048232)	4.10926457
36	rRNA methylation (GO:0031167)	4.04432588
37	calcium ion-dependent exocytosis (GO:0017156)	3.96254293
38	centriole replication (GO:0007099)	3.88663357
39	centriole assembly (GO:0098534)	3.87702238
40	gamete generation (GO:0007276)	3.80683026
41	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.79019174
42	regulation of cilium movement (GO:0003352)	3.75923692
43	negative regulation of inclusion body assembly (GO:0090084)	3.73356739
44	microtubule severing (GO:0051013)	3.73026808
45	germ cell development (GO:0007281)	3.64391708
46	phosphatidylethanolamine metabolic process (GO:0046337)	3.60972063
47	male meiosis (GO:0007140)	3.46274031
48	RNA destabilization (GO:0050779)	3.44504331
49	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.39495673
50	single strand break repair (GO:0000012)	3.38812779
51	response to pheromone (GO:0019236)	3.35597251
52	regulation of ARF GTPase activity (GO:0032312)	3.35083056
53	regulation of dopamine secretion (GO:0014059)	3.34400564
54	ventricular system development (GO:0021591)	3.32387264
55	organic cation transport (GO:0015695)	3.30365462
56	fertilization (GO:0009566)	3.26511316
57	regulation of Rab GTPase activity (GO:0032313)	3.22777963
58	positive regulation of Rab GTPase activity (GO:0032851)	3.22777963
59	activation of protein kinase B activity (GO:0032148)	3.18691611
60	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.14436801
61	glomerular visceral epithelial cell development (GO:0072015)	3.13973665
62	rRNA modification (GO:0000154)	3.07699573
63	acrosome assembly (GO:0001675)	3.05303150
64	response to acidic pH (GO:0010447)	3.03973219
65	multicellular organismal reproductive process (GO:0048609)	2.97304227
66	cranial nerve morphogenesis (GO:0021602)	2.94106578
67	glomerular epithelial cell development (GO:0072310)	2.91318633
68	membrane depolarization during action potential (GO:0086010)	2.89094112
69	intra-Golgi vesicle-mediated transport (GO:0006891)	2.84839972
70	response to muscle activity (GO:0014850)	2.81135477
71	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.72030200
72	cilium organization (GO:0044782)	2.69622565
73	cellular ketone body metabolic process (GO:0046950)	2.68164586
74	cilium assembly (GO:0042384)	2.67364609
75	mitochondrion degradation (GO:0000422)	2.63533898
76	receptor recycling (GO:0001881)	2.61445470
77	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.61093094
78	regulation of inclusion body assembly (GO:0090083)	2.61057028
79	cell recognition (GO:0008037)	2.60614505
80	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.54824159
81	cellular component assembly involved in morphogenesis (GO:0010927)	2.53663087
82	microtubule nucleation (GO:0007020)	2.52828230
83	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.51559852
84	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.51493658
85	axoneme assembly (GO:0035082)	2.49263307
86	myofibril assembly (GO:0030239)	2.47938802
87	regulation of transcription involved in cell fate commitment (GO:0060850)	2.46734919
88	positive regulation of amine transport (GO:0051954)	2.46030201
89	cellular response to pH (GO:0071467)	2.44835024
90	neuromuscular synaptic transmission (GO:0007274)	2.43751327
91	regulation of centriole replication (GO:0046599)	2.43317456
92	cofactor catabolic process (GO:0051187)	2.41686656
93	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.40101529
94	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.40101529
95	multicellular organismal movement (GO:0050879)	2.38537821
96	musculoskeletal movement (GO:0050881)	2.38537821
97	glutamate receptor signaling pathway (GO:0007215)	2.38078513
98	positive regulation of glycolytic process (GO:0045821)	2.37957537
99	cerebral cortex radially oriented cell migration (GO:0021799)	2.34830098
100	regulation of catecholamine secretion (GO:0050433)	2.34023240

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.64461412
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.67271148
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.90574617
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.82083671
5	VDR_22108803_ChIP-Seq_LS180_Human	2.57719907
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49625792
7	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.37924649
8	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.32906705
9	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32906705
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.22160926
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.22160926
12	FUS_26573619_Chip-Seq_HEK293_Human	2.14854212
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14198126
14	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.06144660
15	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96123683
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.95980543
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.85983524
18	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.83950300
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.75281227
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75158678
21	DROSHA_22980978_ChIP-Seq_HELA_Human	1.74714317
22	P300_19829295_ChIP-Seq_ESCs_Human	1.72676533
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.67617782
24	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.67592542
25	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.66842666
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.65283370
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63951090
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63592023
29	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.55167669
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52492243
31	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.43189928
32	TBL1_22424771_ChIP-Seq_293T_Human	1.43189811
33	STAT3_23295773_ChIP-Seq_U87_Human	1.42755639
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.40585049
35	AR_25329375_ChIP-Seq_VCAP_Human	1.40042826
36	AHR_22903824_ChIP-Seq_MCF-7_Human	1.39132899
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38939651
38	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.36983641
39	TP53_18474530_ChIP-ChIP_U2OS_Human	1.36742016
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.36492768
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.35214842
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34983586
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.34478995
44	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.32100253
45	RXR_22108803_ChIP-Seq_LS180_Human	1.31239987
46	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30996570
47	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30666099
48	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.30656280
49	RAC3_21632823_ChIP-Seq_H3396_Human	1.30266135
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29199392
51	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.28314167
52	ERA_21632823_ChIP-Seq_H3396_Human	1.26458913
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.25851109
54	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.25191278
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25153601
56	CTCF_27219007_Chip-Seq_Bcells_Human	1.23373060
57	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.23260982
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.21124082
59	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.20296815
60	TCF4_23295773_ChIP-Seq_U87_Human	1.18683365
61	NFYB_21822215_ChIP-Seq_K562_Human	1.15839637
62	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13538837
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13008427
64	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12104465
65	BCAT_22108803_ChIP-Seq_LS180_Human	1.11609436
66	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10752078
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10619901
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10452830
69	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.10389732
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10337166
71	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.10172932
72	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.08225056
73	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.07887965
74	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.07781695
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07609274
76	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.06679291
77	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.06361007
78	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.06076949
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05570320
80	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05082906
81	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.05006021
82	ETV1_20927104_ChIP-Seq_GIST48_Human	1.04442981
83	MYC_19829295_ChIP-Seq_ESCs_Human	1.03566801
84	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.02849941
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01935411
86	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.01676294
87	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.00780783
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00182587
89	KDM2B_26808549_Chip-Seq_REH_Human	0.99838175
90	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.98788779
91	PHF8_20622853_ChIP-Seq_HELA_Human	0.98084184
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97651091
93	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97259040
94	NFYA_21822215_ChIP-Seq_K562_Human	0.97091411
95	CJUN_26792858_Chip-Seq_BT549_Human	0.96972191
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96909694
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.96545972
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96286672
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.96079187
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94568652

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.23039454
2	MP0003878_abnormal_ear_physiology	2.98308536
3	MP0005377_hearing/vestibular/ear_phenot	2.98308536
4	MP0003698_abnormal_male_reproductive	2.96757056
5	MP0003646_muscle_fatigue	2.72546752
6	MP0002653_abnormal_ependyma_morphology	2.70609737
7	MP0004859_abnormal_synaptic_plasticity	2.63562743
8	MP0001984_abnormal_olfaction	2.62063364
9	MP0003011_delayed_dark_adaptation	2.60392874
10	MP0001929_abnormal_gametogenesis	2.53768604
11	MP0000749_muscle_degeneration	2.38700337
12	MP0004742_abnormal_vestibular_system	2.36457328
13	MP0008004_abnormal_stomach_pH	2.10537568
14	MP0003879_abnormal_hair_cell	2.09693894
15	MP0001486_abnormal_startle_reflex	2.05945710
16	MP0001485_abnormal_pinna_reflex	1.87400734
17	MP0002735_abnormal_chemical_nociception	1.78431182
18	MP0004084_abnormal_cardiac_muscle	1.66557566
19	MP0003635_abnormal_synaptic_transmissio	1.64777691
20	MP0005551_abnormal_eye_electrophysiolog	1.63064645
21	MP0005253_abnormal_eye_physiology	1.60278261
22	MP0002127_abnormal_cardiovascular_syste	1.56950047
23	MP0005499_abnormal_olfactory_system	1.52475427
24	MP0005394_taste/olfaction_phenotype	1.52475427
25	MP0001968_abnormal_touch/_nociception	1.50845009
26	MP0004036_abnormal_muscle_relaxation	1.49816804
27	MP0003136_yellow_coat_color	1.49375042
28	MP0002161_abnormal_fertility/fecundity	1.48336195
29	MP0005167_abnormal_blood-brain_barrier	1.46664305
30	MP0002067_abnormal_sensory_capabilities	1.45412071
31	MP0003315_abnormal_perineum_morphology	1.42362787
32	MP0004233_abnormal_muscle_weight	1.35946032
33	MP0006276_abnormal_autonomic_nervous	1.31969314
34	MP0002272_abnormal_nervous_system	1.30476315
35	MP0002572_abnormal_emotion/affect_behav	1.30125860
36	MP0002210_abnormal_sex_determination	1.27707780
37	MP0002249_abnormal_larynx_morphology	1.26197283
38	MP0009745_abnormal_behavioral_response	1.24896242
39	MP0002108_abnormal_muscle_morphology	1.23817057
40	MP0004510_myositis	1.21843418
41	MP0002132_abnormal_respiratory_system	1.19234044
42	MP0005248_abnormal_Harderian_gland	1.18836446
43	MP0001501_abnormal_sleep_pattern	1.18242337
44	MP0000026_abnormal_inner_ear	1.17576423
45	MP0000955_abnormal_spinal_cord	1.17317630
46	MP0001440_abnormal_grooming_behavior	1.17032334
47	MP0009046_muscle_twitch	1.14177385
48	MP0005423_abnormal_somatic_nervous	1.12424969
49	MP0001963_abnormal_hearing_physiology	1.10754150
50	MP0002063_abnormal_learning/memory/cond	1.09461909
51	MP0010386_abnormal_urinary_bladder	1.08563684
52	MP0001145_abnormal_male_reproductive	1.06293233
53	MP0002752_abnormal_somatic_nervous	1.05603066
54	MP0002269_muscular_atrophy	1.05553153
55	MP0005646_abnormal_pituitary_gland	1.04591693
56	MP0001970_abnormal_pain_threshold	1.02926185
57	MP0003632_abnormal_nervous_system	1.02762261
58	MP0002733_abnormal_thermal_nociception	1.02072655
59	MP0004085_abnormal_heartbeat	1.00256678
60	MP0002229_neurodegeneration	0.98904846
61	MP0000653_abnormal_sex_gland	0.98647892
62	MP0003631_nervous_system_phenotype	0.98464304
63	MP0003718_maternal_effect	0.98138813
64	MP0002184_abnormal_innervation	0.97959400
65	MP0002160_abnormal_reproductive_system	0.96883054
66	MP0001905_abnormal_dopamine_level	0.95843711
67	MP0003122_maternal_imprinting	0.95396626
68	MP0005620_abnormal_muscle_contractility	0.94823327
69	MP0001188_hyperpigmentation	0.94363928
70	MP0002557_abnormal_social/conspecific_i	0.93546892
71	MP0002882_abnormal_neuron_morphology	0.90109425
72	MP0005670_abnormal_white_adipose	0.89933309
73	MP0003787_abnormal_imprinting	0.87419463
74	MP0002102_abnormal_ear_morphology	0.86911089
75	MP0002064_seizures	0.86352992
76	MP0001270_distended_abdomen	0.85535700
77	MP0004145_abnormal_muscle_electrophysio	0.84985774
78	MP0004270_analgesia	0.83943037
79	MP0002736_abnormal_nociception_after	0.83337669
80	MP0003633_abnormal_nervous_system	0.82862148
81	MP0004484_altered_response_of	0.82843721
82	MP0003938_abnormal_ear_development	0.82550998
83	MP0004811_abnormal_neuron_physiology	0.82064120
84	MP0009115_abnormal_fat_cell	0.81989421
85	MP0002837_dystrophic_cardiac_calcinosis	0.81905460
86	MP0003329_amyloid_beta_deposits	0.80178950
87	MP0003638_abnormal_response/metabolism_	0.79885875
88	MP0000230_abnormal_systemic_arterial	0.78702145
89	MP0001756_abnormal_urination	0.77543687
90	MP0005391_vision/eye_phenotype	0.75790056
91	MP0000049_abnormal_middle_ear	0.73198595
92	MP0005595_abnormal_vascular_smooth	0.72180797
93	MP0006072_abnormal_retinal_apoptosis	0.71547664
94	MP0008789_abnormal_olfactory_epithelium	0.71149162
95	MP0002638_abnormal_pupillary_reflex	0.71093766
96	MP0005360_urolithiasis	0.70803207
97	MP0008877_abnormal_DNA_methylation	0.70725064
98	MP0008569_lethality_at_weaning	0.66402972
99	MP0004885_abnormal_endolymph	0.64497714
100	MP0009697_abnormal_copulation	0.64137804

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	6.08498752
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.08498752
3	Abnormal ciliary motility (HP:0012262)	5.55426618
4	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.93690178
5	Abnormal respiratory motile cilium physiology (HP:0012261)	4.92508398
6	Abnormal respiratory epithelium morphology (HP:0012253)	4.66689141
7	Abnormal respiratory motile cilium morphology (HP:0005938)	4.66689141
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.54748678
9	Resting tremor (HP:0002322)	4.08990527
10	Chronic hepatic failure (HP:0100626)	4.03604510
11	Severe visual impairment (HP:0001141)	3.90898365
12	Progressive cerebellar ataxia (HP:0002073)	3.84902489
13	Postural instability (HP:0002172)	3.75267211
14	Tubulointerstitial nephritis (HP:0001970)	3.63523031
15	Abnormality of macular pigmentation (HP:0008002)	3.44620873
16	Rhinitis (HP:0012384)	3.42758286
17	Atonic seizures (HP:0010819)	3.38649307
18	Bony spicule pigmentary retinopathy (HP:0007737)	3.18784929
19	Nasal polyposis (HP:0100582)	3.00113942
20	Attenuation of retinal blood vessels (HP:0007843)	2.98111032
21	Infertility (HP:0000789)	2.90725519
22	Type II lissencephaly (HP:0007260)	2.82190168
23	Cerebellar dysplasia (HP:0007033)	2.81329472
24	Impulsivity (HP:0100710)	2.74109260
25	Pancreatic cysts (HP:0001737)	2.73571255
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.73521323
27	Pancreatic fibrosis (HP:0100732)	2.53147349
28	Retinal dysplasia (HP:0007973)	2.52799294
29	Cone-rod dystrophy (HP:0000548)	2.50949351
30	Abnormality of the nasal mucosa (HP:0000433)	2.49626290
31	Myokymia (HP:0002411)	2.48825132
32	Optic nerve hypoplasia (HP:0000609)	2.43276649
33	Abnormality of the columella (HP:0009929)	2.42642860
34	Febrile seizures (HP:0002373)	2.42028305
35	Hyperkalemia (HP:0002153)	2.39290941
36	Asymmetric septal hypertrophy (HP:0001670)	2.37808505
37	Nephronophthisis (HP:0000090)	2.37281204
38	Clumsiness (HP:0002312)	2.34906909
39	True hermaphroditism (HP:0010459)	2.33668329
40	Muscle hypertrophy of the lower extremities (HP:0008968)	2.33319094
41	Cystic liver disease (HP:0006706)	2.32112837
42	Calf muscle hypertrophy (HP:0008981)	2.31422441
43	Tubulointerstitial abnormality (HP:0001969)	2.24874443
44	Renovascular hypertension (HP:0100817)	2.24355249
45	Abnormal drinking behavior (HP:0030082)	2.23401864
46	Polydipsia (HP:0001959)	2.23401864
47	Inability to walk (HP:0002540)	2.22886041
48	Absent speech (HP:0001344)	2.22664058
49	Hypoplastic ischia (HP:0003175)	2.16594730
50	Abnormality of the ischium (HP:0003174)	2.16530344
51	Myoglobinuria (HP:0002913)	2.11138199
52	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.10184797
53	Midline defect of the nose (HP:0004122)	2.08751910
54	Abnormal urine output (HP:0012590)	2.08472688
55	Polyuria (HP:0000103)	2.08465029
56	Truncal obesity (HP:0001956)	2.05535575
57	Male pseudohermaphroditism (HP:0000037)	2.05267334
58	Abnormality of the renal medulla (HP:0100957)	2.04074068
59	Rimmed vacuoles (HP:0003805)	2.00016814
60	Occipital encephalocele (HP:0002085)	1.99662215
61	Bronchiectasis (HP:0002110)	1.99621194
62	Renal dysplasia (HP:0000110)	1.97844277
63	Male infertility (HP:0003251)	1.96568491
64	Potter facies (HP:0002009)	1.95763423
65	Facial shape deformation (HP:0011334)	1.95763423
66	Abnormality of the shoulder girdle musculature (HP:0001435)	1.95048521
67	Tubular atrophy (HP:0000092)	1.94804861
68	Increased circulating renin level (HP:0000848)	1.93799993
69	Abnormality of the calf musculature (HP:0001430)	1.92056713
70	Abnormality of the pubic bones (HP:0003172)	1.90359178
71	Chronic bronchitis (HP:0004469)	1.88109135
72	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.86978204
73	Hypoplasia of the brainstem (HP:0002365)	1.86978204
74	Exercise-induced myalgia (HP:0003738)	1.85907851
75	Menstrual irregularities (HP:0000858)	1.85100648
76	Syncope (HP:0001279)	1.84911028
77	Sclerocornea (HP:0000647)	1.84642050
78	Ventricular fibrillation (HP:0001663)	1.84217793
79	Polyphagia (HP:0002591)	1.84016372
80	Bile duct proliferation (HP:0001408)	1.83768470
81	Abnormal biliary tract physiology (HP:0012439)	1.83768470
82	Molar tooth sign on MRI (HP:0002419)	1.83652816
83	Abnormality of midbrain morphology (HP:0002418)	1.83652816
84	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.82930160
85	Protruding tongue (HP:0010808)	1.81194341
86	Hyporeflexia of lower limbs (HP:0002600)	1.79188718
87	Genetic anticipation (HP:0003743)	1.78873294
88	Self-mutilation (HP:0000742)	1.78283837
89	Abnormal EKG (HP:0003115)	1.78069453
90	Scapular winging (HP:0003691)	1.76675811
91	Abnormality of renal excretion (HP:0011036)	1.76373929
92	Atrial fibrillation (HP:0005110)	1.74130532
93	Congenital sensorineural hearing impairment (HP:0008527)	1.73175590
94	Portal hypertension (HP:0001409)	1.71029841
95	Bulbous nose (HP:0000414)	1.70748668
96	Vaginal atresia (HP:0000148)	1.70200707
97	Colitis (HP:0002583)	1.69163237
98	Stage 5 chronic kidney disease (HP:0003774)	1.68996011
99	Hypoplasia of the thymus (HP:0000778)	1.67433602
100	Muscular dystrophy (HP:0003560)	1.67323920

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.48115776
2	PLK4	4.14853034
3	STK38L	3.62629480
4	MAP2K7	3.22296820
5	OBSCN	2.84993911
6	INSRR	2.58747566
7	MARK3	2.48094924
8	PNCK	2.27545196
9	LATS1	2.26583135
10	MARK1	2.13617324
11	STK38	2.13102779
12	MAP3K4	2.08795508
13	BRD4	2.07499066
14	FRK	2.02156299
15	CAMK1G	1.82983291
16	SGK494	1.75336808
17	SGK223	1.75336808
18	MAPK15	1.64341643
19	TNIK	1.48028448
20	PLK2	1.47414661
21	BMPR1B	1.46449443
22	MAP3K9	1.43109229
23	NEK2	1.34153151
24	SGK2	1.24546204
25	LATS2	1.23667091
26	SGK3	1.22726565
27	IRAK2	1.08004211
28	PIK3CG	1.06033891
29	MAP3K10	1.02134168
30	AKT3	1.00972166
31	DDR2	0.98787315
32	CASK	0.95553730
33	MAP3K7	0.88209918
34	PTK2B	0.85854600
35	MYLK	0.85030504
36	WNK1	0.83961185
37	CAMK1	0.83163767
38	TYRO3	0.78180733
39	DYRK2	0.77943288
40	PRKCG	0.75707336
41	CAMK1D	0.75101401
42	WNK4	0.73410284
43	PHKG2	0.72142953
44	PHKG1	0.72142953
45	NME1	0.71904609
46	MAP3K1	0.71893264
47	MAPKAPK5	0.70106000
48	RPS6KA5	0.69907115
49	MAP2K4	0.69476448
50	NTRK2	0.66399620
51	CDK3	0.66313768
52	TIE1	0.64930086
53	RET	0.64343269
54	PDPK1	0.62048761
55	STK39	0.59811907
56	MAPK13	0.59676812
57	TLK1	0.59542125
58	CDK12	0.58916103
59	PKN1	0.58537906
60	PDK1	0.57865798
61	SIK2	0.57451172
62	STK3	0.56335067
63	PRKD3	0.55880125
64	PRKG1	0.55250551
65	FGFR2	0.55166509
66	KSR1	0.55003313
67	TRIM28	0.53737573
68	DYRK1B	0.53531794
69	CDK5	0.53373497
70	WNK3	0.53193836
71	NLK	0.53096337
72	ZAK	0.51457749
73	MAPK12	0.50258327
74	PRKCQ	0.50257504
75	MAP3K5	0.49963846
76	EPHB2	0.49231697
77	NEK6	0.48726473
78	PRKG2	0.48495426
79	ROCK1	0.46416118
80	TGFBR1	0.45636181
81	ADRBK2	0.45346346
82	DMPK	0.45060622
83	CAMK2B	0.44722649
84	MINK1	0.42776922
85	MAP3K6	0.40157725
86	CDK14	0.40097736
87	PRKAA2	0.39217038
88	DYRK3	0.38239654
89	SGK1	0.37166910
90	RPS6KA2	0.35683253
91	KSR2	0.35336407
92	PRKAA1	0.34128898
93	CAMK4	0.32509846
94	MELK	0.31936345
95	RPS6KB1	0.31429846
96	CAMK2G	0.30225474
97	PRKACB	0.30166863
98	MAP4K2	0.29595636
99	RPS6KA3	0.29561141
100	MAP3K13	0.29050966

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	3.48611535
2	Nicotine addiction_Homo sapiens_hsa05033	3.00262551
3	Butanoate metabolism_Homo sapiens_hsa00650	2.90053336
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.79080328
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.74639781
6	Taste transduction_Homo sapiens_hsa04742	2.43331821
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.12564205
8	Circadian entrainment_Homo sapiens_hsa04713	2.01418048
9	Glutamatergic synapse_Homo sapiens_hsa04724	1.72917003
10	GABAergic synapse_Homo sapiens_hsa04727	1.70834126
11	Morphine addiction_Homo sapiens_hsa05032	1.70186289
12	Gap junction_Homo sapiens_hsa04540	1.69349370
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64986281
14	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.63085921
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.58933126
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.56486743
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.52213476
18	Phototransduction_Homo sapiens_hsa04744	1.51756344
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.41789762
20	Gastric acid secretion_Homo sapiens_hsa04971	1.37877510
21	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.37810981
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.37409499
23	Renin secretion_Homo sapiens_hsa04924	1.37257010
24	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.37227327
25	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.35694759
26	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.32429668
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.31368062
28	Amphetamine addiction_Homo sapiens_hsa05031	1.31018584
29	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.26731198
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18277351
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.16313771
32	Salivary secretion_Homo sapiens_hsa04970	1.15780245
33	Cholinergic synapse_Homo sapiens_hsa04725	1.13160557
34	Serotonergic synapse_Homo sapiens_hsa04726	1.11138033
35	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.09811748
36	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.06279840
37	Type II diabetes mellitus_Homo sapiens_hsa04930	1.06072376
38	Alcoholism_Homo sapiens_hsa05034	1.05332539
39	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.03361405
40	cAMP signaling pathway_Homo sapiens_hsa04024	1.02690029
41	Long-term depression_Homo sapiens_hsa04730	1.02136494
42	Arginine biosynthesis_Homo sapiens_hsa00220	0.99951148
43	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.96267867
44	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.93614990
45	Insulin secretion_Homo sapiens_hsa04911	0.93569084
46	Cocaine addiction_Homo sapiens_hsa05030	0.92909507
47	Circadian rhythm_Homo sapiens_hsa04710	0.91753871
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.88295965
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87934592
50	ABC transporters_Homo sapiens_hsa02010	0.87910529
51	PPAR signaling pathway_Homo sapiens_hsa03320	0.81179572
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80784232
53	Choline metabolism in cancer_Homo sapiens_hsa05231	0.80093233
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.77047071
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76636348
56	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.75064454
57	Axon guidance_Homo sapiens_hsa04360	0.74789542
58	Fatty acid degradation_Homo sapiens_hsa00071	0.74774060
59	Long-term potentiation_Homo sapiens_hsa04720	0.74764518
60	Phenylalanine metabolism_Homo sapiens_hsa00360	0.74249807
61	MAPK signaling pathway_Homo sapiens_hsa04010	0.73367117
62	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.72200867
63	Propanoate metabolism_Homo sapiens_hsa00640	0.71736344
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71721782
65	Tyrosine metabolism_Homo sapiens_hsa00350	0.67167250
66	Mineral absorption_Homo sapiens_hsa04978	0.64413016
67	Bile secretion_Homo sapiens_hsa04976	0.63927817
68	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.63324060
69	Oocyte meiosis_Homo sapiens_hsa04114	0.63204843
70	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.62440905
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61981913
72	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.60720677
73	Pancreatic secretion_Homo sapiens_hsa04972	0.59054162
74	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.58929867
75	Estrogen signaling pathway_Homo sapiens_hsa04915	0.58460072
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57209001
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55332570
78	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.54734251
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.54646542
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.54627231
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.54457921
82	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53863179
83	Tight junction_Homo sapiens_hsa04530	0.53517440
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52327377
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51003538
86	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.50535144
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50468727
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.47901250
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.47362204
90	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47290698
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.47195837
92	Retinol metabolism_Homo sapiens_hsa00830	0.46223663
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45797711
94	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.45795608
95	Phagosome_Homo sapiens_hsa04145	0.43953110
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43475833
97	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.42015817
98	Basal transcription factors_Homo sapiens_hsa03022	0.41564805
99	Protein digestion and absorption_Homo sapiens_hsa04974	0.40711309
100	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.40183989

ADAM20P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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