ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	phosphate ion transport (GO:0006817)	9.55403444
2	histone H2A acetylation (GO:0043968)	8.64777060
3	peptidyl-tyrosine autophosphorylation (GO:0038083)	8.43090570
4	urate metabolic process (GO:0046415)	7.43246521
5	phosphate ion transmembrane transport (GO:0035435)	7.21997977
6	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	6.79369655
7	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	6.79369655
8	mitochondrion distribution (GO:0048311)	6.11745785
9	tachykinin receptor signaling pathway (GO:0007217)	5.93248604
10	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	5.61677808
11	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.57632409
12	regulation of synaptic transmission, dopaminergic (GO:0032225)	5.53832884
13	response to parathyroid hormone (GO:0071107)	5.47096024
14	regulation of catecholamine metabolic process (GO:0042069)	5.41749093
15	regulation of dopamine metabolic process (GO:0042053)	5.41749093
16	aminoglycoside antibiotic metabolic process (GO:0030647)	5.36917134
17	negative regulation of cAMP-mediated signaling (GO:0043951)	5.36300850
18	regulation of hippo signaling (GO:0035330)	5.30904087
19	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.16183781
20	multicellular organism reproduction (GO:0032504)	4.98448666
21	response to mercury ion (GO:0046689)	4.87219810
22	negative regulation of protein localization to cell surface (GO:2000009)	4.73980109
23	regulation of neurotransmitter uptake (GO:0051580)	4.72009718
24	transmission of nerve impulse (GO:0019226)	4.57883637
25	behavioral response to cocaine (GO:0048148)	4.56140159
26	positive regulation of action potential (GO:0045760)	4.33001994
27	sensory perception of taste (GO:0050909)	4.23827985
28	adaptation of signaling pathway (GO:0023058)	4.20904490
29	regulation of uterine smooth muscle contraction (GO:0070472)	4.18092790
30	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.15129184
31	regulation of natural killer cell differentiation (GO:0032823)	4.13451037
32	trivalent inorganic anion homeostasis (GO:0072506)	4.03535402
33	phosphate ion homeostasis (GO:0055062)	4.03535402
34	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.03197617
35	energy homeostasis (GO:0097009)	4.02960914
36	behavioral response to ethanol (GO:0048149)	3.99118578
37	peristalsis (GO:0030432)	3.97398642
38	behavioral response to nicotine (GO:0035095)	3.86506353
39	synaptic transmission, dopaminergic (GO:0001963)	3.86067530
40	response to lead ion (GO:0010288)	3.79872947
41	regulation of RNA export from nucleus (GO:0046831)	3.79655010
42	positive regulation of heart rate (GO:0010460)	3.78145919
43	hyperosmotic salinity response (GO:0042538)	3.75365804
44	negative regulation of heart rate (GO:0010459)	3.67007301
45	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	3.64569105
46	regulation of penile erection (GO:0060405)	3.63641082
47	positive regulation of amine transport (GO:0051954)	3.60771532
48	short-term memory (GO:0007614)	3.60657991
49	specification of organ identity (GO:0010092)	3.59180446
50	positive regulation of calcium ion import (GO:0090280)	3.55375289
51	response to vitamin A (GO:0033189)	3.55046249
52	positive regulation of signal transduction by p53 class mediator (GO:1901798)	3.54763203
53	sperm-egg recognition (GO:0035036)	3.52128598
54	binding of sperm to zona pellucida (GO:0007339)	3.49794647
55	histone H4-K12 acetylation (GO:0043983)	3.48469182
56	positive regulation of catecholamine secretion (GO:0033605)	3.46247842
57	positive regulation of membrane potential (GO:0045838)	3.42968053
58	regulation of feeding behavior (GO:0060259)	3.40375441
59	detection of bacterium (GO:0016045)	3.37448131
60	response to magnesium ion (GO:0032026)	3.37352987
61	epoxygenase P450 pathway (GO:0019373)	3.37126197
62	hindbrain development (GO:0030902)	3.28744596
63	chemosensory behavior (GO:0007635)	3.25285117
64	reproduction (GO:0000003)	3.20149327
65	indole-containing compound metabolic process (GO:0042430)	3.19702767
66	maternal behavior (GO:0042711)	3.17899256
67	regulation of G0 to G1 transition (GO:0070316)	3.09985452
68	cell-cell recognition (GO:0009988)	3.09874248
69	xenobiotic catabolic process (GO:0042178)	3.07658020
70	detection of light stimulus involved in visual perception (GO:0050908)	3.07284289
71	detection of light stimulus involved in sensory perception (GO:0050962)	3.07284289
72	opioid receptor signaling pathway (GO:0038003)	3.05057167
73	regulation of action potential (GO:0098900)	3.00480931
74	regulation of nucleobase-containing compound transport (GO:0032239)	2.98513105
75	glycoprotein catabolic process (GO:0006516)	2.96586737
76	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.96355866
77	positive regulation of histone H3-K4 methylation (GO:0051571)	2.94314356
78	negative regulation of JAK-STAT cascade (GO:0046426)	2.94162291
79	detection of other organism (GO:0098543)	2.93875746
80	negative regulation of dendrite development (GO:2000171)	2.92958040
81	prenylation (GO:0097354)	2.92650518
82	protein prenylation (GO:0018342)	2.92650518
83	mitochondrion localization (GO:0051646)	2.91592058
84	positive regulation of protein kinase C signaling (GO:0090037)	2.91550007
85	head development (GO:0060322)	2.90113985
86	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.88576064
87	negative regulation of Rho protein signal transduction (GO:0035024)	2.88119513
88	DNA methylation involved in gamete generation (GO:0043046)	2.85513732
89	positive regulation of heart contraction (GO:0045823)	2.84203288
90	parental behavior (GO:0060746)	2.80235753
91	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.79086372
92	pentose metabolic process (GO:0019321)	2.78807377
93	chromatin silencing (GO:0006342)	2.78573025
94	response to growth hormone (GO:0060416)	2.78170168
95	positive regulation of systemic arterial blood pressure (GO:0003084)	2.73332928
96	negative regulation of cation channel activity (GO:2001258)	2.71626548
97	positive regulation of T cell chemotaxis (GO:0010820)	2.70366970
98	regulation of T cell chemotaxis (GO:0010819)	2.70366970
99	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.68823240
100	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.68349104

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.66191707
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.03184200
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.46087828
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.32474465
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.20424076
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80336115
7	ZNF263_19887448_ChIP-Seq_K562_Human	2.55927738
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.53844917
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40905710
10	DROSHA_22980978_ChIP-Seq_HELA_Human	2.34276320
11	FUS_26573619_Chip-Seq_HEK293_Human	2.32443692
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.23645730
13	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.23579762
14	RXR_22108803_ChIP-Seq_LS180_Human	2.01660207
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.96604942
16	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.90054610
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.87763821
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.76889049
19	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.76798193
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.75678017
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.75597731
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74331705
23	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.72768606
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.71448047
25	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.70507771
26	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.65980978
27	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.65980978
28	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.61006310
29	STAT3_23295773_ChIP-Seq_U87_Human	1.60607593
30	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.59737229
31	AHR_22903824_ChIP-Seq_MCF-7_Human	1.59331875
32	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.58526046
33	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.57981132
34	VDR_22108803_ChIP-Seq_LS180_Human	1.57797186
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55750434
36	RUNX2_22187159_ChIP-Seq_PCA_Human	1.55591487
37	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.53301921
38	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.50410520
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49804197
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47872491
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47572865
42	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.47434778
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47154669
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.44963756
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43075689
46	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.42364710
47	* AR_25329375_ChIP-Seq_VCAP_Human	1.41281355
48	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.40628067
49	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.38336298
50	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.34428910
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33571814
52	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31661001
53	STAT1_17558387_ChIP-Seq_HELA_Human	1.31637206
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31533202
55	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.28572399
56	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.27842452
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.27808018
58	P300_19829295_ChIP-Seq_ESCs_Human	1.27322031
59	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.24428973
60	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.24178098
61	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22993370
62	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.22881562
63	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.22693331
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19900285
65	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.19793570
66	TP53_18474530_ChIP-ChIP_U2OS_Human	1.19667255
67	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.18043496
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17889856
69	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.14732630
70	KDM2B_26808549_Chip-Seq_REH_Human	1.13400829
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11701484
72	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11080966
73	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.10026418
74	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.08276263
75	OCT4_20526341_ChIP-Seq_ESCs_Human	1.07913712
76	ERA_21632823_ChIP-Seq_H3396_Human	1.05106280
77	CJUN_26792858_Chip-Seq_BT549_Human	1.04679190
78	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.04553106
79	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03834833
80	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.03698463
81	BCAT_22108803_ChIP-Seq_LS180_Human	1.03604359
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.01515770
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00768903
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99349022
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98692060
86	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98495977
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97343046
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97060130
89	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.96313538
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95398853
91	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.94986938
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94795008
93	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.92323420
94	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91841639
95	PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human	0.91112859
96	* NCOR_22424771_ChIP-Seq_293T_Human	0.90964630
97	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.90392546
98	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.89714770
99	AR_21572438_ChIP-Seq_LNCaP_Human	0.89478772
100	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.89266468

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	4.07777622
2	MP0005377_hearing/vestibular/ear_phenot	4.07777622
3	MP0002138_abnormal_hepatobiliary_system	3.39431154
4	MP0004510_myositis	3.04448062
5	MP0005397_hematopoietic_system_phenotyp	2.99990164
6	MP0001545_abnormal_hematopoietic_system	2.99990164
7	MP0002332_abnormal_exercise_endurance	2.98873942
8	MP0005645_abnormal_hypothalamus_physiol	2.65568916
9	MP0002160_abnormal_reproductive_system	2.64702857
10	MP0003045_fibrosis	2.53806190
11	MP0005410_abnormal_fertilization	2.53181186
12	MP0004859_abnormal_synaptic_plasticity	2.46735083
13	MP0001348_abnormal_lacrimal_gland	2.42352686
14	MP0001486_abnormal_startle_reflex	2.09460569
15	MP0002735_abnormal_chemical_nociception	2.08681610
16	MP0001485_abnormal_pinna_reflex	2.05969011
17	MP0005551_abnormal_eye_electrophysiolog	2.05727102
18	MP0004019_abnormal_vitamin_homeostasis	1.90731320
19	MP0005423_abnormal_somatic_nervous	1.85732493
20	MP0006276_abnormal_autonomic_nervous	1.84500505
21	MP0003315_abnormal_perineum_morphology	1.80557715
22	MP0003252_abnormal_bile_duct	1.80547771
23	MP0003136_yellow_coat_color	1.78799415
24	MP0010386_abnormal_urinary_bladder	1.74988319
25	MP0003635_abnormal_synaptic_transmissio	1.68956327
26	MP0008775_abnormal_heart_ventricle	1.67828372
27	MP0005670_abnormal_white_adipose	1.64846833
28	MP0001501_abnormal_sleep_pattern	1.62475984
29	MP0004147_increased_porphyrin_level	1.60850044
30	MP0001905_abnormal_dopamine_level	1.57992414
31	MP0002063_abnormal_learning/memory/cond	1.57912141
32	MP0004808_abnormal_hematopoietic_stem	1.56182906
33	MP0000383_abnormal_hair_follicle	1.55364408
34	MP0005319_abnormal_enzyme/_coenzyme	1.54043056
35	MP0008004_abnormal_stomach_pH	1.51913710
36	MP0000427_abnormal_hair_cycle	1.51551494
37	MP0000747_muscle_weakness	1.48572709
38	MP0005360_urolithiasis	1.46301911
39	MP0004782_abnormal_surfactant_physiolog	1.42723160
40	MP0002928_abnormal_bile_duct	1.41810121
41	MP0002733_abnormal_thermal_nociception	1.40110410
42	MP0000749_muscle_degeneration	1.40092423
43	MP0002572_abnormal_emotion/affect_behav	1.37589272
44	MP0000678_abnormal_parathyroid_gland	1.36853167
45	MP0004085_abnormal_heartbeat	1.35851676
46	MP0003183_abnormal_peptide_metabolism	1.33352860
47	MP0004133_heterotaxia	1.32946372
48	MP0004215_abnormal_myocardial_fiber	1.32803825
49	MP0000538_abnormal_urinary_bladder	1.32668906
50	MP0009745_abnormal_behavioral_response	1.31384266
51	MP0001984_abnormal_olfaction	1.31126484
52	MP0010678_abnormal_skin_adnexa	1.30210462
53	MP0005367_renal/urinary_system_phenotyp	1.28590230
54	MP0000516_abnormal_urinary_system	1.28590230
55	MP0005647_abnormal_sex_gland	1.28538860
56	MP0005389_reproductive_system_phenotype	1.27462731
57	MP0005195_abnormal_posterior_eye	1.26805135
58	MP0006138_congestive_heart_failure	1.24972555
59	MP0006072_abnormal_retinal_apoptosis	1.24920604
60	MP0009333_abnormal_splenocyte_physiolog	1.20183960
61	MP0003698_abnormal_male_reproductive	1.17680325
62	MP0009046_muscle_twitch	1.14073266
63	MP0004858_abnormal_nervous_system	1.08087213
64	MP0001970_abnormal_pain_threshold	1.07876179
65	MP0001849_ear_inflammation	1.07312401
66	MP0003283_abnormal_digestive_organ	1.06349511
67	MP0003959_abnormal_lean_body	1.03857259
68	MP0009765_abnormal_xenobiotic_induced	1.01524539
69	MP0002184_abnormal_innervation	1.01250368
70	MP0005220_abnormal_exocrine_pancreas	1.01138656
71	MP0002752_abnormal_somatic_nervous	0.98642862
72	MP0000604_amyloidosis	0.98244280
73	MP0010368_abnormal_lymphatic_system	0.97861711
74	MP0002272_abnormal_nervous_system	0.97195129
75	MP0004272_abnormal_basement_membrane	0.95822419
76	MP0000955_abnormal_spinal_cord	0.94534649
77	MP0001765_abnormal_ion_homeostasis	0.92397598
78	MP0002971_abnormal_brown_adipose	0.91786098
79	MP0009672_abnormal_birth_weight	0.90551717
80	MP0000462_abnormal_digestive_system	0.87482501
81	MP0002168_other_aberrant_phenotype	0.85099173
82	MP0000465_gastrointestinal_hemorrhage	0.84864434
83	MP0001764_abnormal_homeostasis	0.83645809
84	MP0002067_abnormal_sensory_capabilities	0.83199548
85	MP0008877_abnormal_DNA_methylation	0.81688870
86	MP0001664_abnormal_digestion	0.81155046
87	MP0006035_abnormal_mitochondrial_morpho	0.79174650
88	MP0003880_abnormal_central_pattern	0.77730703
89	MP0002069_abnormal_eating/drinking_beha	0.76391536
90	MP0002229_neurodegeneration	0.76152275
91	MP0001293_anophthalmia	0.75063351
92	MP0005266_abnormal_metabolism	0.74937815
93	MP0001963_abnormal_hearing_physiology	0.74639827
94	MP0002734_abnormal_mechanical_nocicepti	0.73549932
95	MP0005253_abnormal_eye_physiology	0.73530837
96	MP0003943_abnormal_hepatobiliary_system	0.71940467
97	MP0005187_abnormal_penis_morphology	0.71922242
98	MP0001929_abnormal_gametogenesis	0.70367913
99	MP0001756_abnormal_urination	0.70316127
100	MP0004145_abnormal_muscle_electrophysio	0.70209130

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Generalized aminoaciduria (HP:0002909)	9.43027363
2	Proximal tubulopathy (HP:0000114)	6.93423407
3	Severe visual impairment (HP:0001141)	6.60762113
4	Pendular nystagmus (HP:0012043)	6.57054023
5	Congenital stationary night blindness (HP:0007642)	5.79072285
6	Popliteal pterygium (HP:0009756)	5.10390007
7	Fetal akinesia sequence (HP:0001989)	4.74200540
8	Myokymia (HP:0002411)	4.50510195
9	True hermaphroditism (HP:0010459)	4.09393231
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.93303428
11	Pancreatic fibrosis (HP:0100732)	3.89428875
12	Amniotic constriction ring (HP:0009775)	3.81310736
13	Abnormality of placental membranes (HP:0011409)	3.81310736
14	Pancreatic cysts (HP:0001737)	3.74547217
15	Tongue fasciculations (HP:0001308)	3.62737517
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.43900739
17	Abolished electroretinogram (ERG) (HP:0000550)	3.29484959
18	Acute lymphatic leukemia (HP:0006721)	3.27944302
19	Cystic liver disease (HP:0006706)	3.27206980
20	Attenuation of retinal blood vessels (HP:0007843)	3.22513118
21	Increased corneal curvature (HP:0100692)	3.19821274
22	Keratoconus (HP:0000563)	3.19821274
23	Muscle fibrillation (HP:0010546)	3.16778367
24	Hyperkalemia (HP:0002153)	3.07145980
25	Clumsiness (HP:0002312)	3.03726199
26	Abnormality of urine glucose concentration (HP:0011016)	2.94350964
27	Glycosuria (HP:0003076)	2.94350964
28	Aplasia of the musculature (HP:0100854)	2.86621159
29	Retinal atrophy (HP:0001105)	2.77531634
30	Rib fusion (HP:0000902)	2.72403359
31	Thoracic kyphosis (HP:0002942)	2.71583710
32	Malignant hyperthermia (HP:0002047)	2.68275587
33	Sclerocornea (HP:0000647)	2.53999251
34	Congenital sensorineural hearing impairment (HP:0008527)	2.51041228
35	Optic nerve hypoplasia (HP:0000609)	2.49954335
36	Anencephaly (HP:0002323)	2.49787991
37	Retinal dysplasia (HP:0007973)	2.44821889
38	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.42744100
39	Decreased central vision (HP:0007663)	2.42596575
40	Poor eye contact (HP:0000817)	2.38768936
41	Cystic hygroma (HP:0000476)	2.38245223
42	Abnormality of macular pigmentation (HP:0008002)	2.36875617
43	Genetic anticipation (HP:0003743)	2.32313060
44	Chorioretinal atrophy (HP:0000533)	2.31583136
45	Abnormality of DNA repair (HP:0003254)	2.30091564
46	Male pseudohermaphroditism (HP:0000037)	2.28921445
47	Abnormality of the renal collecting system (HP:0004742)	2.28459954
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.28245789
49	Abnormality of the columella (HP:0009929)	2.27270399
50	Renal dysplasia (HP:0000110)	2.25875055
51	Decreased circulating renin level (HP:0003351)	2.22650918
52	Bile duct proliferation (HP:0001408)	2.20234214
53	Abnormal biliary tract physiology (HP:0012439)	2.20234214
54	Furrowed tongue (HP:0000221)	2.20107951
55	Action tremor (HP:0002345)	2.19212924
56	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.18501915
57	Abnormality of the labia majora (HP:0012881)	2.17517577
58	Rickets (HP:0002748)	2.16932081
59	Fused cervical vertebrae (HP:0002949)	2.14335463
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.07911450
61	Stenosis of the external auditory canal (HP:0000402)	2.06159338
62	Severe muscular hypotonia (HP:0006829)	2.04895775
63	Hypercalciuria (HP:0002150)	2.03103842
64	Abnormality of the lumbar spine (HP:0100712)	2.02054874
65	Poikiloderma (HP:0001029)	2.02017587
66	Hydroxyprolinuria (HP:0003080)	1.99584465
67	Abnormality of proline metabolism (HP:0010907)	1.99584465
68	Submucous cleft hard palate (HP:0000176)	1.98216278
69	Pterygium (HP:0001059)	1.97934389
70	Morphological abnormality of the middle ear (HP:0008609)	1.96573391
71	J-shaped sella turcica (HP:0002680)	1.95969738
72	Recurrent corneal erosions (HP:0000495)	1.94865906
73	Parakeratosis (HP:0001036)	1.94169933
74	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.94093114
75	Hyperphosphaturia (HP:0003109)	1.93627778
76	Absent speech (HP:0001344)	1.92348505
77	Congenital hepatic fibrosis (HP:0002612)	1.88343349
78	Neonatal death (HP:0003811)	1.87030567
79	Pigmentary retinal degeneration (HP:0001146)	1.86521171
80	Abnormal auditory evoked potentials (HP:0006958)	1.85608081
81	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.81821892
82	Postaxial foot polydactyly (HP:0001830)	1.81817115
83	Pachygyria (HP:0001302)	1.80896862
84	Neonatal respiratory distress (HP:0002643)	1.80542510
85	Focal seizures (HP:0007359)	1.78374860
86	Upper limb muscle weakness (HP:0003484)	1.77754066
87	Rocker bottom foot (HP:0001838)	1.77177353
88	Abnormality of chloride homeostasis (HP:0011422)	1.71257898
89	Type 2 muscle fiber atrophy (HP:0003554)	1.71145370
90	Nonprogressive disorder (HP:0003680)	1.70050976
91	Gait imbalance (HP:0002141)	1.69773653
92	Neoplasm of the peripheral nervous system (HP:0100007)	1.68518821
93	Abnormality of fatty-acid metabolism (HP:0004359)	1.68280843
94	Akinesia (HP:0002304)	1.67898601
95	Type II lissencephaly (HP:0007260)	1.67645807
96	Impaired social interactions (HP:0000735)	1.66653718
97	Abnormal social behavior (HP:0012433)	1.66653718
98	Intellectual disability, progressive (HP:0006887)	1.64576386
99	Erectile abnormalities (HP:0100639)	1.63115497
100	Oligodontia (HP:0000677)	1.62546314

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	6.54512655
2	PRPF4B	6.37862975
3	TAOK2	4.78589726
4	FRK	3.83707388
5	PINK1	3.44960282
6	INSRR	2.70995106
7	LATS1	2.45705209
8	ADRBK2	2.29775763
9	TXK	2.05603604
10	MARK1	2.05518893
11	MST1R	1.80373745
12	BMPR1B	1.64671902
13	AURKA	1.60862638
14	OBSCN	1.39902740
15	PRKD3	1.30091187
16	PHKG2	1.27503858
17	PHKG1	1.27503858
18	GRK1	1.25579511
19	RPS6KA5	1.25401497
20	GRK7	1.23365957
21	OXSR1	1.16629312
22	MOS	1.12297740
23	FGFR2	1.10946008
24	TYRO3	1.06037131
25	LATS2	1.00785140
26	CDK8	0.99589151
27	NTRK3	0.98291038
28	MAPK13	0.98034212
29	TGFBR1	0.96061607
30	DAPK2	0.93367856
31	MAP3K7	0.90755158
32	PRKG2	0.89609261
33	MARK3	0.87189062
34	TLK1	0.86846881
35	PRKAA1	0.83935986
36	FER	0.82808615
37	TGFBR2	0.81797537
38	DYRK2	0.80395301
39	PRKCG	0.77697412
40	MAP2K7	0.75879327
41	MYLK	0.74700616
42	CASK	0.74225986
43	MAP4K2	0.73123756
44	CHEK2	0.71808031
45	CDK12	0.71143678
46	PDGFRA	0.70431480
47	ZAK	0.69741421
48	EEF2K	0.68772980
49	PKN1	0.68762440
50	ERBB3	0.68129327
51	RPS6KA4	0.63046047
52	SGK223	0.62937138
53	SGK494	0.62937138
54	TRPM7	0.61821452
55	MAP2K6	0.60927304
56	RPS6KB2	0.60162307
57	PTK2B	0.59359653
58	PRKACB	0.57480777
59	DDR2	0.56695440
60	MAPKAPK3	0.56203770
61	MET	0.55469159
62	PRKCH	0.54799348
63	STK11	0.53367510
64	WNK3	0.50805080
65	PRKCD	0.48559113
66	MAP4K1	0.47681349
67	GRK5	0.45797362
68	JAK3	0.45330458
69	MAP2K1	0.43551617
70	CAMK2B	0.43443678
71	MAPK10	0.41618739
72	CSNK1A1	0.41218156
73	CHEK1	0.40701147
74	PRKACA	0.39450726
75	PAK1	0.39187676
76	MUSK	0.39144975
77	ADRBK1	0.39024470
78	BCKDK	0.38872438
79	MARK2	0.38075166
80	EGFR	0.37962419
81	RPS6KB1	0.36707377
82	ILK	0.36044196
83	CSNK1A1L	0.35826269
84	RPS6KA2	0.35756496
85	CSNK1E	0.34301853
86	CSNK1G3	0.33793456
87	INSR	0.33739761
88	RPS6KA3	0.32191296
89	MAPK8	0.31993485
90	CAMK2A	0.31323086
91	IRAK3	0.31234077
92	TIE1	0.28390107
93	PDK1	0.28065819
94	NTRK2	0.27950970
95	SRC	0.27694232
96	STK38L	0.27376880
97	STK38	0.26965579
98	TNK2	0.26486131
99	SYK	0.26203847
100	PRKCE	0.24941019

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Renin-angiotensin system_Homo sapiens_hsa04614	5.74708274
2	Phototransduction_Homo sapiens_hsa04744	3.14916490
3	Taste transduction_Homo sapiens_hsa04742	2.98923453
4	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.89188689
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.87101500
6	Nicotine addiction_Homo sapiens_hsa05033	2.62524968
7	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.61392967
8	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.34671265
9	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.22612459
10	Butanoate metabolism_Homo sapiens_hsa00650	2.14499417
11	Retinol metabolism_Homo sapiens_hsa00830	2.14323819
12	Chemical carcinogenesis_Homo sapiens_hsa05204	1.98301581
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.97745852
14	Gap junction_Homo sapiens_hsa04540	1.88425637
15	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.87325816
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76794765
17	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.73280168
18	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.70536544
19	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.63005900
20	Sulfur relay system_Homo sapiens_hsa04122	1.48617915
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41622768
22	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.40197198
23	Sulfur metabolism_Homo sapiens_hsa00920	1.38332062
24	Morphine addiction_Homo sapiens_hsa05032	1.36734270
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.29015618
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24912081
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.24610917
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.23493750
29	Caffeine metabolism_Homo sapiens_hsa00232	1.16646027
30	Olfactory transduction_Homo sapiens_hsa04740	1.16324117
31	GABAergic synapse_Homo sapiens_hsa04727	1.15787969
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.13036264
33	ABC transporters_Homo sapiens_hsa02010	1.11238540
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10815129
35	Glutamatergic synapse_Homo sapiens_hsa04724	1.09652437
36	Bile secretion_Homo sapiens_hsa04976	1.05675093
37	Renin secretion_Homo sapiens_hsa04924	1.02214696
38	Salivary secretion_Homo sapiens_hsa04970	1.01171385
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.00979556
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.99506061
41	Cocaine addiction_Homo sapiens_hsa05030	0.98474455
42	Circadian entrainment_Homo sapiens_hsa04713	0.97269623
43	Arginine biosynthesis_Homo sapiens_hsa00220	0.97230372
44	Circadian rhythm_Homo sapiens_hsa04710	0.94413733
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.93027457
46	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.90730595
47	Axon guidance_Homo sapiens_hsa04360	0.86203155
48	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.86117731
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.83414938
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80383496
51	African trypanosomiasis_Homo sapiens_hsa05143	0.76949854
52	Amphetamine addiction_Homo sapiens_hsa05031	0.74192918
53	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.71934390
54	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.71878330
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.70006895
56	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.69108624
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65617104
58	Protein digestion and absorption_Homo sapiens_hsa04974	0.63707802
59	Fatty acid degradation_Homo sapiens_hsa00071	0.62241784
60	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61531976
61	Alcoholism_Homo sapiens_hsa05034	0.60547786
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59365291
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58838165
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58595497
65	Gastric acid secretion_Homo sapiens_hsa04971	0.58380396
66	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.57956680
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.57926182
68	PPAR signaling pathway_Homo sapiens_hsa03320	0.57890953
69	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.57572004
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55252419
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54011148
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52872925
73	AMPK signaling pathway_Homo sapiens_hsa04152	0.52763805
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.51647217
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50388588
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49299339
77	Glucagon signaling pathway_Homo sapiens_hsa04922	0.45477234
78	Serotonergic synapse_Homo sapiens_hsa04726	0.45185177
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.43763702
80	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.42370556
81	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.39894525
82	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.39377357
83	Cholinergic synapse_Homo sapiens_hsa04725	0.37319329
84	Peroxisome_Homo sapiens_hsa04146	0.36458085
85	ErbB signaling pathway_Homo sapiens_hsa04012	0.35139099
86	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.34593499
87	ECM-receptor interaction_Homo sapiens_hsa04512	0.33293059
88	Homologous recombination_Homo sapiens_hsa03440	0.33175515
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.31861253
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.31197855
91	Ras signaling pathway_Homo sapiens_hsa04014	0.30461156
92	Histidine metabolism_Homo sapiens_hsa00340	0.28639237
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28394488
94	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.27811521
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26618991
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.25233998
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24791439
98	Other glycan degradation_Homo sapiens_hsa00511	0.24695211
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24214521
100	One carbon pool by folate_Homo sapiens_hsa00670	0.22212749

ADAM21P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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