ADAM22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)5.78814862
2sodium ion export (GO:0071436)5.39515498
3amino sugar catabolic process (GO:0046348)5.29531136
4cerebellar granule cell differentiation (GO:0021707)5.08637729
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08054688
6positive regulation of viral genome replication (GO:0045070)5.00916096
7postsynaptic membrane organization (GO:0001941)4.83537744
8N-acetylneuraminate metabolic process (GO:0006054)4.77245900
9synaptic vesicle exocytosis (GO:0016079)4.53916569
10fructose metabolic process (GO:0006000)4.52414109
11synaptic vesicle maturation (GO:0016188)4.46904156
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.37780457
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.36941476
14lung-associated mesenchyme development (GO:0060484)4.34007596
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.32933418
16vocalization behavior (GO:0071625)4.27446093
17neuronal action potential propagation (GO:0019227)4.26990723
18locomotory exploration behavior (GO:0035641)4.22074668
19neuromuscular process controlling posture (GO:0050884)4.17694936
20ADP metabolic process (GO:0046031)4.11460920
21positive regulation of membrane potential (GO:0045838)4.08523752
22amino acid import (GO:0043090)4.08387046
23potassium ion homeostasis (GO:0055075)4.07138223
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.06451916
25cell migration in hindbrain (GO:0021535)4.04894613
26cerebellar Purkinje cell differentiation (GO:0021702)4.02388385
27neuron cell-cell adhesion (GO:0007158)4.02352894
28potassium ion import (GO:0010107)4.00687539
29axon ensheathment in central nervous system (GO:0032291)3.95365340
30central nervous system myelination (GO:0022010)3.95365340
31glutamate secretion (GO:0014047)3.94068523
32purine nucleobase biosynthetic process (GO:0009113)3.93709270
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.91192357
34cell communication by electrical coupling (GO:0010644)3.88180652
35cellular sodium ion homeostasis (GO:0006883)3.86969680
36layer formation in cerebral cortex (GO:0021819)3.83653259
37negative regulation of dendrite morphogenesis (GO:0050774)3.82640224
38auditory behavior (GO:0031223)3.80362747
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.77861573
40regulation of synaptic vesicle exocytosis (GO:2000300)3.77742171
41synaptic transmission, glutamatergic (GO:0035249)3.77033005
42neuronal ion channel clustering (GO:0045161)3.76665220
43nucleobase biosynthetic process (GO:0046112)3.72972152
44regulation of neurotransmitter secretion (GO:0046928)3.70140258
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.70004387
46regulation of synapse maturation (GO:0090128)3.67021634
47neuron-neuron synaptic transmission (GO:0007270)3.66531771
48protein localization to synapse (GO:0035418)3.64808672
49synaptic vesicle endocytosis (GO:0048488)3.56055892
50chaperone-mediated protein transport (GO:0072321)3.55432236
51glutamate receptor signaling pathway (GO:0007215)3.54691984
52positive regulation of dendritic spine morphogenesis (GO:0061003)3.53634648
53neurotransmitter secretion (GO:0007269)3.52181801
54L-amino acid import (GO:0043092)3.51413442
55regulation of DNA methylation (GO:0044030)3.51359507
56positive regulation of dendritic spine development (GO:0060999)3.43647890
57C4-dicarboxylate transport (GO:0015740)3.39064947
58membrane depolarization (GO:0051899)3.38995469
59regulation of voltage-gated calcium channel activity (GO:1901385)3.38581697
60regulation of neurotransmitter transport (GO:0051588)3.38015793
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.36324006
62regulation of glutamate receptor signaling pathway (GO:1900449)3.35967635
63mechanosensory behavior (GO:0007638)3.35556339
64regulation of ARF protein signal transduction (GO:0032012)3.35093040
65regulation of neuronal synaptic plasticity (GO:0048168)3.32188747
66gamma-aminobutyric acid transport (GO:0015812)3.32021854
67response to auditory stimulus (GO:0010996)3.31492595
68exploration behavior (GO:0035640)3.27680379
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.25284362
70regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24745352
71transcription elongation from RNA polymerase I promoter (GO:0006362)3.23695044
72otic vesicle formation (GO:0030916)3.22570468
73regulation of dendritic spine morphogenesis (GO:0061001)3.21592466
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21405124
75peptidyl-threonine dephosphorylation (GO:0035970)3.20169328
76proline transport (GO:0015824)3.14999494
77neuromuscular synaptic transmission (GO:0007274)3.14991224
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12362456
79keratinocyte development (GO:0003334)3.11892528
80cell communication involved in cardiac conduction (GO:0086065)3.10920847
81neuromuscular process (GO:0050905)3.10906455
82neurotransmitter transport (GO:0006836)3.09867492
83regulation of synaptic vesicle transport (GO:1902803)3.09737479
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06332900
85termination of RNA polymerase I transcription (GO:0006363)3.06332856
86innervation (GO:0060384)3.05194010
87long-term memory (GO:0007616)3.04155496
88adult walking behavior (GO:0007628)3.04023450
89gamma-aminobutyric acid signaling pathway (GO:0007214)3.00993109
90synaptic transmission (GO:0007268)3.00750141
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00440680
92regulation of synaptic transmission (GO:0050804)2.97772007
93dendrite morphogenesis (GO:0048813)2.97405464
94regulation of dendritic spine development (GO:0060998)2.97147678
95positive regulation of neurotransmitter transport (GO:0051590)2.95482134
96regulation of synapse structural plasticity (GO:0051823)2.93933786
97dendritic spine morphogenesis (GO:0060997)2.90633023
98ATP hydrolysis coupled proton transport (GO:0015991)2.89052751
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.89052751
100regulation of cellular amino acid metabolic process (GO:0006521)2.88760347
101positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.87279933
102regulation of neurotransmitter levels (GO:0001505)2.86284592
103mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.84794548
104neurotransmitter uptake (GO:0001504)2.84406900
105neuron recognition (GO:0008038)2.83939758
106regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83718409
107regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83621358
108regulation of collateral sprouting (GO:0048670)2.83073330
109axonal fasciculation (GO:0007413)2.82317945
110cullin deneddylation (GO:0010388)2.81146036
111neurotransmitter-gated ion channel clustering (GO:0072578)2.80906443
112nucleoside diphosphate biosynthetic process (GO:0009133)2.80185499
113transmission of nerve impulse (GO:0019226)2.78604725
114presynaptic membrane assembly (GO:0097105)2.78111493
115acidic amino acid transport (GO:0015800)2.77896994
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77809630
117determination of adult lifespan (GO:0008340)2.77440746
118behavioral fear response (GO:0001662)2.76333872
119behavioral defense response (GO:0002209)2.76333872
120chemosensory behavior (GO:0007635)2.74192148
121neuromuscular process controlling balance (GO:0050885)2.73334759
122L-glutamate transport (GO:0015813)2.73312292
123positive regulation of synapse maturation (GO:0090129)2.70675390
124cell differentiation in hindbrain (GO:0021533)2.70492782
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70168161
126autophagic vacuole assembly (GO:0000045)2.69757401
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69662666
128presynaptic membrane organization (GO:0097090)2.68991539
129regulation of postsynaptic membrane potential (GO:0060078)2.67206099
130blastocyst development (GO:0001824)2.66022736
131nucleoside diphosphate phosphorylation (GO:0006165)2.65994136
132negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.64582012
133positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.64304325
134transcription initiation from RNA polymerase I promoter (GO:0006361)2.64064091
135membrane hyperpolarization (GO:0060081)2.64015769
136rRNA modification (GO:0000154)2.63670854
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62399389
138membrane depolarization during action potential (GO:0086010)2.61986077
139fear response (GO:0042596)2.56588659
140regulation of synaptic plasticity (GO:0048167)2.54721264
141transcription from RNA polymerase I promoter (GO:0006360)2.53893237
142regulation of vesicle fusion (GO:0031338)2.53594029
143long-term synaptic potentiation (GO:0060291)2.53537251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.62473964
2EZH2_22144423_ChIP-Seq_EOC_Human4.59852990
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.61304560
4GBX2_23144817_ChIP-Seq_PC3_Human3.27567092
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75559159
6REST_21632747_ChIP-Seq_MESCs_Mouse2.59996871
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.45437604
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.41448462
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33365147
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28626046
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.17539677
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15623207
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13908061
14* TAF15_26573619_Chip-Seq_HEK293_Human2.13710942
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12786855
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06597647
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00870402
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00800138
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.94469403
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94175389
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.93603537
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.88599834
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.86727658
24AR_21572438_ChIP-Seq_LNCaP_Human1.83046523
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79188433
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.72735134
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71917874
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63197004
29DROSHA_22980978_ChIP-Seq_HELA_Human1.63101652
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62805552
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61004537
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60529554
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59886274
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59486787
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58345536
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54739980
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54715531
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53693652
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51768492
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50888189
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50449844
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.48458355
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48390268
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.47579158
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.45348155
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44880821
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44823143
48RNF2_27304074_Chip-Seq_NSC_Mouse1.41954926
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40128661
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37902267
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37488173
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36722782
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35733111
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35733111
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35043106
56* AR_19668381_ChIP-Seq_PC3_Human1.34881241
57CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.33197733
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32735605
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32499627
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.32274759
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31313870
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30344973
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30090899
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29321017
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29192258
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28373590
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.28324368
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27563876
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26488640
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24979789
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.23271418
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.22259693
73FUS_26573619_Chip-Seq_HEK293_Human1.22028125
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20675443
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.19654421
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18718915
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18381370
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17718045
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17019817
80* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16481747
81* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16473931
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15997005
83NANOG_16518401_ChIP-PET_MESCs_Mouse1.15940131
84* STAT3_23295773_ChIP-Seq_U87_Human1.15647527
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15483929
86* SMAD4_21799915_ChIP-Seq_A2780_Human1.15438357
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.14886915
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14366828
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14125638
90* TCF4_23295773_ChIP-Seq_U87_Human1.11987053
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11969071
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11594494
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10805743
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10216982
95E2F7_22180533_ChIP-Seq_HELA_Human1.09790787
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09301960
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09179919
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08994042
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08927507
100AR_21909140_ChIP-Seq_LNCAP_Human1.08899700
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08797013
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08626563
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08626563
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07562682
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07522446
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06585683
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06503127
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06310568
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05770846
110MYC_18555785_ChIP-Seq_MESCs_Mouse1.05192442
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.04826334
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04506127
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04272394
114* ER_23166858_ChIP-Seq_MCF-7_Human1.03901339
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02885136
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02154517
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01532613
118* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01425306
119KDM2B_26808549_Chip-Seq_K562_Human1.01244726
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00801993
121SOX9_26525672_Chip-Seq_HEART_Mouse1.00738859
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00202738
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99880551
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99804258
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.99616146
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98491962
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97150159
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97059659
129P300_19829295_ChIP-Seq_ESCs_Human0.96935333
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96281792
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.96164996
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.95748218
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94330069
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94296209
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93666962
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.93395589
137SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92984336
138ETV1_20927104_ChIP-Seq_GIST48_Human0.92616165
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92460430
140KDM2B_26808549_Chip-Seq_REH_Human0.91707073
141* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91401843
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91371596
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91066843
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90919252
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90785780
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.90530286
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89951594
148RNF2_27304074_Chip-Seq_ESCs_Mouse0.89858941
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89240180
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.89213652
151KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88999442
152AR_25329375_ChIP-Seq_VCAP_Human0.88169666
153IGF1R_20145208_ChIP-Seq_DFB_Human0.86942484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25002690
2MP0003880_abnormal_central_pattern5.06944493
3MP0008260_abnormal_autophagy3.95945709
4MP0003806_abnormal_nucleotide_metabolis3.83619328
5MP0003635_abnormal_synaptic_transmissio3.44857416
6MP0004270_analgesia3.14357652
7MP0009745_abnormal_behavioral_response2.97627068
8* MP0002064_seizures2.91957122
9MP0009046_muscle_twitch2.91082979
10MP0002822_catalepsy2.77421809
11MP0001968_abnormal_touch/_nociception2.67016471
12MP0002063_abnormal_learning/memory/cond2.56031404
13MP0002272_abnormal_nervous_system2.41443327
14MP0001440_abnormal_grooming_behavior2.39436234
15MP0003718_maternal_effect2.30810408
16MP0002572_abnormal_emotion/affect_behav2.26690855
17MP0002734_abnormal_mechanical_nocicepti2.16550794
18MP0005423_abnormal_somatic_nervous2.13673410
19MP0006292_abnormal_olfactory_placode2.12834493
20MP0002736_abnormal_nociception_after2.09451794
21MP0008877_abnormal_DNA_methylation2.06614563
22MP0001486_abnormal_startle_reflex2.06521605
23MP0002735_abnormal_chemical_nociception2.03293360
24MP0004957_abnormal_blastocyst_morpholog1.92569758
25MP0002067_abnormal_sensory_capabilities1.84911241
26MP0001501_abnormal_sleep_pattern1.78643446
27MP0004885_abnormal_endolymph1.78034534
28MP0002733_abnormal_thermal_nociception1.75156651
29MP0001970_abnormal_pain_threshold1.74693909
30MP0003693_abnormal_embryo_hatching1.67501195
31* MP0008569_lethality_at_weaning1.65675213
32MP0004142_abnormal_muscle_tone1.65642026
33MP0000778_abnormal_nervous_system1.65560965
34MP0003329_amyloid_beta_deposits1.61302547
35MP0003122_maternal_imprinting1.55458654
36MP0002557_abnormal_social/conspecific_i1.47609241
37MP0001502_abnormal_circadian_rhythm1.47320364
38MP0004924_abnormal_behavior1.45521183
39MP0005386_behavior/neurological_phenoty1.45521183
40MP0003111_abnormal_nucleus_morphology1.44268815
41MP0002638_abnormal_pupillary_reflex1.42404361
42MP0002184_abnormal_innervation1.39264799
43MP0002909_abnormal_adrenal_gland1.38915226
44MP0003123_paternal_imprinting1.37584122
45MP0001485_abnormal_pinna_reflex1.34303592
46MP0001529_abnormal_vocalization1.34175772
47* MP0002066_abnormal_motor_capabilities/c1.33201071
48MP0004742_abnormal_vestibular_system1.31347125
49MP0001905_abnormal_dopamine_level1.28099415
50MP0004811_abnormal_neuron_physiology1.27595883
51MP0004145_abnormal_muscle_electrophysio1.26258837
52MP0003632_abnormal_nervous_system1.25446562
53MP0005409_darkened_coat_color1.23896110
54MP0000955_abnormal_spinal_cord1.23416111
55MP0006276_abnormal_autonomic_nervous1.22796605
56MP0008057_abnormal_DNA_replication1.19251622
57MP0003315_abnormal_perineum_morphology1.15093451
58MP0003950_abnormal_plasma_membrane1.14695354
59MP0003879_abnormal_hair_cell1.10779300
60MP0008058_abnormal_DNA_repair1.08458759
61* MP0002882_abnormal_neuron_morphology1.08199910
62MP0001188_hyperpigmentation1.07705188
63MP0002229_neurodegeneration1.06073677
64MP0001984_abnormal_olfaction1.05441713
65MP0003631_nervous_system_phenotype1.03612014
66MP0000569_abnormal_digit_pigmentation0.94440603
67MP0009697_abnormal_copulation0.92296369
68MP0001963_abnormal_hearing_physiology0.92145153
69MP0001542_abnormal_bone_strength0.91812586
70MP0003690_abnormal_glial_cell0.91651570
71* MP0000920_abnormal_myelination0.91516603
72MP0002152_abnormal_brain_morphology0.90040717
73MP0001299_abnormal_eye_distance/0.89587372
74MP0008872_abnormal_physiological_respon0.88875852
75MP0010386_abnormal_urinary_bladder0.88503788
76MP0003633_abnormal_nervous_system0.88157819
77MP0003787_abnormal_imprinting0.86106865
78MP0001177_atelectasis0.86100872
79MP0003121_genomic_imprinting0.84096433
80MP0006035_abnormal_mitochondrial_morpho0.82680693
81MP0000631_abnormal_neuroendocrine_gland0.82211521
82MP0003861_abnormal_nervous_system0.82114568
83MP0004147_increased_porphyrin_level0.81179921
84MP0003283_abnormal_digestive_organ0.80683895
85* MP0003634_abnormal_glial_cell0.79886024
86MP0004043_abnormal_pH_regulation0.79231634
87MP0001346_abnormal_lacrimal_gland0.78709361
88MP0005395_other_phenotype0.78002052
89MP0001348_abnormal_lacrimal_gland0.77064396
90MP0000579_abnormal_nail_morphology0.75679265
91MP0003077_abnormal_cell_cycle0.74363514
92MP0005646_abnormal_pituitary_gland0.74007490
93MP0002653_abnormal_ependyma_morphology0.72899282
94MP0002277_abnormal_respiratory_mucosa0.72517846
95MP0005551_abnormal_eye_electrophysiolog0.71861292
96MP0006072_abnormal_retinal_apoptosis0.71616237
97MP0002069_abnormal_eating/drinking_beha0.70712046
98MP0004858_abnormal_nervous_system0.70092937
99* MP0010770_preweaning_lethality0.69994131
100* MP0002082_postnatal_lethality0.69994131
101MP0004215_abnormal_myocardial_fiber0.69469825
102MP0008874_decreased_physiological_sensi0.69106854
103MP0005623_abnormal_meninges_morphology0.68937362
104MP0005645_abnormal_hypothalamus_physiol0.68783902
105MP0004085_abnormal_heartbeat0.67743858
106MP0004130_abnormal_muscle_cell0.67711966
107MP0000604_amyloidosis0.67679042
108MP0010094_abnormal_chromosome_stability0.67169491
109MP0002837_dystrophic_cardiac_calcinosis0.66642514
110MP0001943_abnormal_respiration0.65895298
111MP0008932_abnormal_embryonic_tissue0.64667609
112MP0002751_abnormal_autonomic_nervous0.63772841
113MP0005187_abnormal_penis_morphology0.62760059
114MP0002752_abnormal_somatic_nervous0.60002689
115MP0009780_abnormal_chondrocyte_physiolo0.59860023
116MP0001727_abnormal_embryo_implantation0.59825598
117MP0000372_irregular_coat_pigmentation0.58142043
118MP0002009_preneoplasia0.57900079
119* MP0010769_abnormal_survival0.57403721
120MP0001986_abnormal_taste_sensitivity0.56268654
121* MP0003956_abnormal_body_size0.55954101
122* MP0010768_mortality/aging0.55787080
123MP0005167_abnormal_blood-brain_barrier0.55419202
124MP0003136_yellow_coat_color0.55125255
125MP0003938_abnormal_ear_development0.54441814
126MP0003137_abnormal_impulse_conducting0.53918453
127MP0005535_abnormal_body_temperature0.53072234
128MP0002249_abnormal_larynx_morphology0.52920169
129* MP0002081_perinatal_lethality0.52704884

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.90017634
2Myokymia (HP:0002411)5.68019061
3Hyperventilation (HP:0002883)4.58905750
4Focal seizures (HP:0007359)4.42478512
5Epileptic encephalopathy (HP:0200134)4.22076937
6Atonic seizures (HP:0010819)3.73820670
7Neurofibrillary tangles (HP:0002185)3.46968838
8Limb dystonia (HP:0002451)3.45510596
9Dialeptic seizures (HP:0011146)3.39535809
10Cerebral hypomyelination (HP:0006808)3.37467135
11Visual hallucinations (HP:0002367)3.37009606
12Abnormality of the labia minora (HP:0012880)3.36639440
13Progressive cerebellar ataxia (HP:0002073)3.29340058
14Absence seizures (HP:0002121)3.20533775
15Postural instability (HP:0002172)3.17520721
16Obstructive sleep apnea (HP:0002870)3.17307785
17Abnormality of the corticospinal tract (HP:0002492)3.12951553
18Papilledema (HP:0001085)3.12252029
19Febrile seizures (HP:0002373)3.09418910
20Oligodactyly (hands) (HP:0001180)3.07209659
21Action tremor (HP:0002345)2.99515552
22Generalized tonic-clonic seizures (HP:0002069)2.99397765
23Broad-based gait (HP:0002136)2.97948308
24CNS hypomyelination (HP:0003429)2.95696467
25Annular pancreas (HP:0001734)2.95095137
26Septo-optic dysplasia (HP:0100842)2.85626425
27Status epilepticus (HP:0002133)2.84651735
28Gaze-evoked nystagmus (HP:0000640)2.84423066
29Absent speech (HP:0001344)2.83848460
30Hyperglycinemia (HP:0002154)2.82050634
31Delusions (HP:0000746)2.80757573
32Urinary bladder sphincter dysfunction (HP:0002839)2.74505790
33Cerebral inclusion bodies (HP:0100314)2.72676904
34Torticollis (HP:0000473)2.71806547
35Lower limb muscle weakness (HP:0007340)2.59886242
36Pheochromocytoma (HP:0002666)2.59531553
37Spastic gait (HP:0002064)2.59269142
38Dysmetric saccades (HP:0000641)2.58664616
39Ankle clonus (HP:0011448)2.52505364
40Abnormality of the lower motor neuron (HP:0002366)2.48171374
41Aplasia of the phalanges of the hand (HP:0009802)2.47385027
42Aplasia involving bones of the extremities (HP:0009825)2.47385027
43Aplasia involving bones of the upper limbs (HP:0009823)2.47385027
44Akinesia (HP:0002304)2.44713733
45Maternal diabetes (HP:0009800)2.41905228
46Abnormal social behavior (HP:0012433)2.41025550
47Impaired social interactions (HP:0000735)2.41025550
48Rough bone trabeculation (HP:0100670)2.39065726
49Amblyopia (HP:0000646)2.38417811
50Epileptiform EEG discharges (HP:0011182)2.38152731
51Impaired vibration sensation in the lower limbs (HP:0002166)2.37900188
52Postnatal microcephaly (HP:0005484)2.36328180
53Sleep apnea (HP:0010535)2.34161142
54Impaired vibratory sensation (HP:0002495)2.32186876
55Poor eye contact (HP:0000817)2.31990785
56Bradykinesia (HP:0002067)2.30956745
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30409169
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.30409169
59Insomnia (HP:0100785)2.29795643
60EEG with generalized epileptiform discharges (HP:0011198)2.27643411
61Dysmetria (HP:0001310)2.25348652
62Abnormal umbilical cord blood vessels (HP:0011403)2.25128885
63Single umbilical artery (HP:0001195)2.25128885
64Abnormality of the fetal cardiovascular system (HP:0010948)2.25128885
65Anxiety (HP:0000739)2.24642370
66Stenosis of the external auditory canal (HP:0000402)2.23743945
67Neuroendocrine neoplasm (HP:0100634)2.22942883
68Megalencephaly (HP:0001355)2.19805473
69Hypsarrhythmia (HP:0002521)2.19675203
70Morphological abnormality of the pyramidal tract (HP:0002062)2.17509308
71Spinal muscular atrophy (HP:0007269)2.17387652
72Diplopia (HP:0000651)2.14702395
73Abnormality of binocular vision (HP:0011514)2.14702395
74Pancreatic fibrosis (HP:0100732)2.14435728
75Tongue fasciculations (HP:0001308)2.13059708
76Abnormal eating behavior (HP:0100738)2.12258633
77Peripheral hypomyelination (HP:0007182)2.12206037
78Impaired smooth pursuit (HP:0007772)2.11798110
79Osteomalacia (HP:0002749)2.09899854
80Intention tremor (HP:0002080)2.09060913
81Truncal ataxia (HP:0002078)2.08329414
82Turricephaly (HP:0000262)2.07943949
83Neuronal loss in central nervous system (HP:0002529)2.07421671
84Abnormality of the anterior horn cell (HP:0006802)2.07112117
85Degeneration of anterior horn cells (HP:0002398)2.07112117
86Agnosia (HP:0010524)2.05126686
87Dysdiadochokinesis (HP:0002075)2.02883730
88Amyotrophic lateral sclerosis (HP:0007354)2.02417093
89Stereotypic behavior (HP:0000733)2.01145777
90Restlessness (HP:0000711)1.99566223
91Nasolacrimal duct obstruction (HP:0000579)1.98716579
92Spastic tetraparesis (HP:0001285)1.98115170
93Abnormality of ocular smooth pursuit (HP:0000617)1.97722383
94Urinary urgency (HP:0000012)1.97674778
95Split foot (HP:0001839)1.94745556
96Increased circulating renin level (HP:0000848)1.93341679
97Hepatic necrosis (HP:0002605)1.92936829
98Supranuclear gaze palsy (HP:0000605)1.91792052
99Craniofacial dystonia (HP:0012179)1.91710611
100Tetraplegia (HP:0002445)1.90726944
101Scanning speech (HP:0002168)1.89370404
102Clonus (HP:0002169)1.89263945
103Carpal bone hypoplasia (HP:0001498)1.88925148
104Muscle fibrillation (HP:0010546)1.87439475
105Hemiparesis (HP:0001269)1.86929386
106Abnormality of saccadic eye movements (HP:0000570)1.84822534
107Abnormal hair whorl (HP:0010721)1.83647287
108Choreoathetosis (HP:0001266)1.83637031
109Hepatocellular necrosis (HP:0001404)1.83062665
110Dysautonomia (HP:0002459)1.82217535
111Unsteady gait (HP:0002317)1.82122349
112Abnormality of glycine metabolism (HP:0010895)1.80268834
113Abnormality of serine family amino acid metabolism (HP:0010894)1.80268834
114Generalized myoclonic seizures (HP:0002123)1.80227490
115Lower limb asymmetry (HP:0100559)1.78551000
116Absent septum pellucidum (HP:0001331)1.78464394
117Impulsivity (HP:0100710)1.77248562
118Mutism (HP:0002300)1.76720341
119Protruding tongue (HP:0010808)1.75822892
120Depression (HP:0000716)1.75706687
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75078705
122Apathy (HP:0000741)1.74964553
123Rigidity (HP:0002063)1.73984950
124Gait ataxia (HP:0002066)1.73883337
125Neoplasm of the peripheral nervous system (HP:0100007)1.73430089
126Bronchomalacia (HP:0002780)1.73213668
127Drooling (HP:0002307)1.73114534
128Excessive salivation (HP:0003781)1.73114534
129Genetic anticipation (HP:0003743)1.72922742
130Fair hair (HP:0002286)1.72766479
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72212787
132Spastic paraplegia (HP:0001258)1.71952233
133Incomplete penetrance (HP:0003829)1.70911853
134Cutaneous finger syndactyly (HP:0010554)1.70840560
135Alacrima (HP:0000522)1.67310691
136Hemiplegia (HP:0002301)1.67308168
137Premature graying of hair (HP:0002216)1.65630670
138Focal dystonia (HP:0004373)1.64804918
139Abnormality of the salivary glands (HP:0010286)1.64572418
140Abnormality of the septum pellucidum (HP:0007375)1.64354730
141Irritability (HP:0000737)1.64132630
142Fetal akinesia sequence (HP:0001989)1.62361070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.38302914
2EPHA44.25739660
3ARAF3.88140367
4NTRK33.15614533
5PNCK2.78115984
6MAP3K122.69529947
7STK162.44240122
8TSSK62.44141430
9WEE12.25576350
10EIF2AK32.19280867
11NME12.17236458
12MAP3K42.10155366
13CASK1.96956071
14MARK11.96324349
15MINK11.87206532
16MAP2K71.81863375
17PRKD31.67508911
18TNIK1.65380297
19AKT31.64530594
20CCNB11.58366039
21PIM21.55778082
22MAP3K91.52672745
23NTRK11.52215383
24NTRK21.51968741
25MKNK11.49425446
26MKNK21.38958677
27BRAF1.38548746
28PLK31.36640136
29PRKCG1.30587973
30PRKCH1.28587179
31ALK1.28011994
32RIPK11.26413308
33EIF2AK11.21481327
34GRK51.16210647
35PLK21.14793578
36FGFR21.11392262
37OXSR11.05839993
38MAP2K41.05385140
39KSR21.04674078
40DAPK11.04187646
41RAF11.04167763
42CAMKK21.02955530
43MAPK131.01903568
44PINK11.00475365
45CAMK1G0.96599964
46RIPK40.96534304
47VRK10.96350310
48DAPK20.94811297
49CDK50.92127735
50CDK190.91062921
51FES0.90439341
52CAMKK10.87282682
53PKN10.86960526
54SGK2230.84201893
55SGK4940.84201893
56BUB10.83913441
57NUAK10.81853943
58PAK60.80833402
59CAMK40.80657617
60MARK20.80621962
61LATS20.80544404
62NEK60.80519777
63RET0.77954331
64CDK180.73352652
65MAPK120.71306152
66CDK140.69968581
67CDK150.69563037
68PRPF4B0.69415334
69STK380.69303528
70SGK20.69241366
71CAMK2B0.66144510
72PDGFRA0.64898851
73UHMK10.62674367
74BRSK10.61068076
75CAMK2A0.60220664
76PRKCE0.58139153
77BCR0.57678865
78CDK11A0.57358193
79WNK30.56332527
80CAMK10.56269633
81CAMK2G0.53554214
82PBK0.53545210
83PDK20.53534447
84PDK10.52985303
85PRKCI0.51549453
86AURKA0.50370859
87EEF2K0.50259885
88KSR10.49969985
89CSNK1E0.49808889
90PHKG10.49785820
91PHKG20.49785820
92PAK10.48782629
93SGK30.48033587
94PLK10.47639096
95PRKCZ0.47518191
96CAMK1D0.46076973
97ROCK20.45930545
98SRPK10.45875256
99STK110.44785694
100MAPKAPK50.44488752
101SIK20.44176960
102CSNK1D0.44101878
103MAPK100.42988112
104PRKDC0.42098762
105CSNK1G20.42064541
106PRKACB0.42035994
107WNK10.41399583
108BMPR20.41313097
109CSNK1A10.40911810
110DYRK1A0.40633798
111MAP3K130.38914131
112ICK0.38856906
113FYN0.38537882
114SGK10.38096404
115CDK30.37784520
116PRKACA0.37349191
117TYRO30.37329563
118PDPK10.37138522
119RPS6KA30.37100436
120CDK10.36844731
121CSNK1G30.36727324
122DMPK0.36583906
123GSK3B0.36097512
124INSRR0.35735669
125RPS6KA20.35074099
126RPS6KB10.34434148
127CDK20.33997153
128CAMK2D0.33533363
129PAK30.32988701
130MAPK80.32594278
131PRKCB0.32108325
132CSNK1A1L0.30252791
133ERBB20.30135372
134PRKG10.30002253

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76332722
2Proteasome_Homo sapiens_hsa030503.57871832
3Regulation of autophagy_Homo sapiens_hsa041403.25654645
4Synaptic vesicle cycle_Homo sapiens_hsa047213.05603628
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83488197
6GABAergic synapse_Homo sapiens_hsa047272.40518463
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.38526561
8Collecting duct acid secretion_Homo sapiens_hsa049662.30863002
9RNA polymerase_Homo sapiens_hsa030202.15880177
10Amphetamine addiction_Homo sapiens_hsa050312.15110286
11Pentose phosphate pathway_Homo sapiens_hsa000302.11816706
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07046796
13Glutamatergic synapse_Homo sapiens_hsa047242.00236391
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98159339
15Circadian entrainment_Homo sapiens_hsa047131.93567239
16Morphine addiction_Homo sapiens_hsa050321.91716067
17Long-term potentiation_Homo sapiens_hsa047201.88593802
18Olfactory transduction_Homo sapiens_hsa047401.86659996
19Fructose and mannose metabolism_Homo sapiens_hsa000511.84695271
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74670142
21Taste transduction_Homo sapiens_hsa047421.52343583
22Vitamin B6 metabolism_Homo sapiens_hsa007501.49123196
23Oocyte meiosis_Homo sapiens_hsa041141.48585429
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47785251
25Dopaminergic synapse_Homo sapiens_hsa047281.43675808
26Oxidative phosphorylation_Homo sapiens_hsa001901.39535956
27Salivary secretion_Homo sapiens_hsa049701.37267004
28Insulin secretion_Homo sapiens_hsa049111.35864703
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33909643
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32195949
31Parkinsons disease_Homo sapiens_hsa050121.21645056
32Glioma_Homo sapiens_hsa052141.18949907
33RNA transport_Homo sapiens_hsa030131.16805938
34Calcium signaling pathway_Homo sapiens_hsa040201.14971527
35Vibrio cholerae infection_Homo sapiens_hsa051101.13865165
36Cholinergic synapse_Homo sapiens_hsa047251.09465118
37Long-term depression_Homo sapiens_hsa047301.08435379
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07913906
39Nitrogen metabolism_Homo sapiens_hsa009101.06175324
40Gastric acid secretion_Homo sapiens_hsa049711.06023687
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04509960
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.03713357
43Huntingtons disease_Homo sapiens_hsa050161.03553974
44Serotonergic synapse_Homo sapiens_hsa047261.03478054
45Type II diabetes mellitus_Homo sapiens_hsa049301.03344102
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03269490
47Thyroid hormone synthesis_Homo sapiens_hsa049181.02520202
48Mismatch repair_Homo sapiens_hsa034301.02218137
49Melanogenesis_Homo sapiens_hsa049161.01279441
50Cocaine addiction_Homo sapiens_hsa050301.00577887
51Alzheimers disease_Homo sapiens_hsa050101.00357945
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99050634
53Bile secretion_Homo sapiens_hsa049760.98064186
54Cardiac muscle contraction_Homo sapiens_hsa042600.97994850
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97479915
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96629424
57Carbon metabolism_Homo sapiens_hsa012000.93355275
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93192406
59Renin secretion_Homo sapiens_hsa049240.91061326
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89646883
61Oxytocin signaling pathway_Homo sapiens_hsa049210.86588562
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.86257397
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86116884
64Pyrimidine metabolism_Homo sapiens_hsa002400.84078936
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83166261
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82182006
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81825578
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80576458
69Purine metabolism_Homo sapiens_hsa002300.77723239
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75988642
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.75388183
72Biosynthesis of amino acids_Homo sapiens_hsa012300.75251230
73Inositol phosphate metabolism_Homo sapiens_hsa005620.74088057
74Gap junction_Homo sapiens_hsa045400.73146474
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71811486
76Fatty acid elongation_Homo sapiens_hsa000620.71784638
77Choline metabolism in cancer_Homo sapiens_hsa052310.70349908
78Rap1 signaling pathway_Homo sapiens_hsa040150.68571671
79Butanoate metabolism_Homo sapiens_hsa006500.67748958
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65996614
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65335271
82MAPK signaling pathway_Homo sapiens_hsa040100.65112997
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64639693
84Alcoholism_Homo sapiens_hsa050340.64272206
85Ras signaling pathway_Homo sapiens_hsa040140.63773353
86Dorso-ventral axis formation_Homo sapiens_hsa043200.62870834
87Glucagon signaling pathway_Homo sapiens_hsa049220.61471932
88Basal transcription factors_Homo sapiens_hsa030220.61099149
89Fatty acid biosynthesis_Homo sapiens_hsa000610.60588119
90Type I diabetes mellitus_Homo sapiens_hsa049400.60551763
91Arginine biosynthesis_Homo sapiens_hsa002200.60483854
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60447016
93Homologous recombination_Homo sapiens_hsa034400.58889161
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58783288
95Folate biosynthesis_Homo sapiens_hsa007900.57317726
96Prion diseases_Homo sapiens_hsa050200.57198778
97Phototransduction_Homo sapiens_hsa047440.55605928
98Dilated cardiomyopathy_Homo sapiens_hsa054140.55368457
99Endometrial cancer_Homo sapiens_hsa052130.55096227
100cAMP signaling pathway_Homo sapiens_hsa040240.55059068
101VEGF signaling pathway_Homo sapiens_hsa043700.53646212
102Wnt signaling pathway_Homo sapiens_hsa043100.52137358
103mTOR signaling pathway_Homo sapiens_hsa041500.50843442
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.49819969
105Ribosome_Homo sapiens_hsa030100.49286737
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.47760965
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.47630275
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47246367
109Nucleotide excision repair_Homo sapiens_hsa034200.46019207
110AMPK signaling pathway_Homo sapiens_hsa041520.42632402
111GnRH signaling pathway_Homo sapiens_hsa049120.42405302
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41768291
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41704258
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40982039
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40863500
116Hippo signaling pathway_Homo sapiens_hsa043900.40815647
117Circadian rhythm_Homo sapiens_hsa047100.40783180
118Axon guidance_Homo sapiens_hsa043600.39507071
119Colorectal cancer_Homo sapiens_hsa052100.38440158
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37995804
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.37597251
122Ovarian steroidogenesis_Homo sapiens_hsa049130.37126219
123Pancreatic secretion_Homo sapiens_hsa049720.36851336
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36003905
125Insulin signaling pathway_Homo sapiens_hsa049100.35430981
126Estrogen signaling pathway_Homo sapiens_hsa049150.34626737
127Tight junction_Homo sapiens_hsa045300.34185580
128Spliceosome_Homo sapiens_hsa030400.33814442
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32490034
130ErbB signaling pathway_Homo sapiens_hsa040120.31659121
131Non-small cell lung cancer_Homo sapiens_hsa052230.31459205
132Cell cycle_Homo sapiens_hsa041100.31293078
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30765698
134Endocytosis_Homo sapiens_hsa041440.30690318
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28988232
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28586254
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27047170
138Prolactin signaling pathway_Homo sapiens_hsa049170.26983303
139Renal cell carcinoma_Homo sapiens_hsa052110.26751711
140Rheumatoid arthritis_Homo sapiens_hsa053230.26745844
141Metabolic pathways_Homo sapiens_hsa011000.23344892
142beta-Alanine metabolism_Homo sapiens_hsa004100.23225920
143Histidine metabolism_Homo sapiens_hsa003400.23066533
144Mineral absorption_Homo sapiens_hsa049780.20921453
145Arginine and proline metabolism_Homo sapiens_hsa003300.20605583
146ABC transporters_Homo sapiens_hsa020100.20093505

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