ADAM23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42129587
2synaptic vesicle maturation (GO:0016188)5.35003048
3neuronal action potential propagation (GO:0019227)5.27804877
4locomotory exploration behavior (GO:0035641)5.17820229
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10551665
6vocalization behavior (GO:0071625)5.09083957
7synaptic vesicle exocytosis (GO:0016079)5.01295220
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85205019
9glutamate secretion (GO:0014047)4.75863831
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.69553498
11regulation of synaptic vesicle exocytosis (GO:2000300)4.62436730
12regulation of glutamate receptor signaling pathway (GO:1900449)4.46447525
13protein localization to synapse (GO:0035418)4.42283055
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.40117363
15neuron cell-cell adhesion (GO:0007158)4.37252277
16neurotransmitter secretion (GO:0007269)4.29873829
17exploration behavior (GO:0035640)4.15757531
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.14709091
19regulation of synaptic vesicle transport (GO:1902803)4.09076171
20regulation of neuronal synaptic plasticity (GO:0048168)4.06204036
21glutamate receptor signaling pathway (GO:0007215)4.02519252
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01136042
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99426327
24positive regulation of dendritic spine morphogenesis (GO:0061003)3.96336033
25cell communication involved in cardiac conduction (GO:0086065)3.92081334
26synaptic transmission, glutamatergic (GO:0035249)3.89573612
27neuron-neuron synaptic transmission (GO:0007270)3.88612668
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87529560
29gamma-aminobutyric acid transport (GO:0015812)3.86341351
30neuromuscular process controlling posture (GO:0050884)3.85723124
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84146149
32cerebellar Purkinje cell differentiation (GO:0021702)3.83829021
33negative regulation of dendrite morphogenesis (GO:0050774)3.78123885
34regulation of synapse structural plasticity (GO:0051823)3.74814784
35layer formation in cerebral cortex (GO:0021819)3.70926742
36regulation of vesicle fusion (GO:0031338)3.70888290
37cell migration in hindbrain (GO:0021535)3.67531090
38cellular potassium ion homeostasis (GO:0030007)3.65032566
39proline transport (GO:0015824)3.64520437
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64296515
41L-amino acid import (GO:0043092)3.61639162
42transmission of nerve impulse (GO:0019226)3.56538796
43activation of protein kinase A activity (GO:0034199)3.55824485
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.54203933
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.54091786
46neurotransmitter-gated ion channel clustering (GO:0072578)3.51880298
47neuron recognition (GO:0008038)3.51640121
48regulation of postsynaptic membrane potential (GO:0060078)3.51576453
49neuromuscular process controlling balance (GO:0050885)3.49629397
50membrane depolarization during action potential (GO:0086010)3.48985161
51neurotransmitter transport (GO:0006836)3.47563098
52prepulse inhibition (GO:0060134)3.46708702
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.46538299
54innervation (GO:0060384)3.43387880
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.42971555
56cellular sodium ion homeostasis (GO:0006883)3.40680221
57dendritic spine morphogenesis (GO:0060997)3.38473717
58neurofilament cytoskeleton organization (GO:0060052)3.37195950
59long-term memory (GO:0007616)3.36541050
60regulation of dendritic spine morphogenesis (GO:0061001)3.36378725
61potassium ion homeostasis (GO:0055075)3.36276667
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36205100
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35536760
64detection of calcium ion (GO:0005513)3.35254339
65positive regulation of dendritic spine development (GO:0060999)3.34468295
66negative regulation of dendrite development (GO:2000171)3.33876321
67sodium ion export (GO:0071436)3.33540239
68regulation of synaptic plasticity (GO:0048167)3.32735243
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.31553969
70amino acid import (GO:0043090)3.31537071
71positive regulation of membrane potential (GO:0045838)3.28240547
72regulation of cell communication by electrical coupling (GO:0010649)3.26538306
73membrane depolarization (GO:0051899)3.25351130
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24427097
75regulation of neurotransmitter levels (GO:0001505)3.23836737
76potassium ion import (GO:0010107)3.22929624
77synaptic vesicle endocytosis (GO:0048488)3.21517169
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20015460
79membrane hyperpolarization (GO:0060081)3.17687591
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15852445
81long-term synaptic potentiation (GO:0060291)3.15718067
82vesicle transport along microtubule (GO:0047496)3.14901415
83regulation of neurotransmitter secretion (GO:0046928)3.14153853
84axonal fasciculation (GO:0007413)3.13999076
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.13779238
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10348940
87response to auditory stimulus (GO:0010996)3.10189961
88regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.09990645
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09850937
90presynaptic membrane assembly (GO:0097105)3.09768498
91neuromuscular process (GO:0050905)3.08077912
92cerebellar granule cell differentiation (GO:0021707)3.07826416
93adult walking behavior (GO:0007628)3.07208667
94dendrite morphogenesis (GO:0048813)3.06452350
95glycine transport (GO:0015816)3.06396350
96regulation of glutamate secretion (GO:0014048)3.05900384
97postsynaptic membrane organization (GO:0001941)3.05849284
98regulation of voltage-gated calcium channel activity (GO:1901385)3.04253879
99synapse assembly (GO:0007416)3.02012219
100neuronal ion channel clustering (GO:0045161)3.00743797
101cell communication by electrical coupling (GO:0010644)3.00669859
102regulation of actin filament-based movement (GO:1903115)3.00595316
103regulation of cardiac muscle cell contraction (GO:0086004)3.00473138
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99580707
105positive regulation of synapse maturation (GO:0090129)2.99393535
106response to histamine (GO:0034776)2.98084781
107regulation of dendritic spine development (GO:0060998)2.97602416
108short-term memory (GO:0007614)2.97473389
109organelle transport along microtubule (GO:0072384)2.97464275
110positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.97272821
111presynaptic membrane organization (GO:0097090)2.96753226
112regulation of neurotransmitter transport (GO:0051588)2.95847075
113establishment of mitochondrion localization (GO:0051654)2.93608037
114auditory behavior (GO:0031223)2.92956205
115striatum development (GO:0021756)2.92859547
116synaptic transmission (GO:0007268)2.92384821
117suckling behavior (GO:0001967)2.89629911
118cardiac muscle contraction (GO:0060048)2.88090892
119regulation of synapse maturation (GO:0090128)2.86210579
120learning (GO:0007612)2.85960235
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85411462
122positive regulation of neurotransmitter transport (GO:0051590)2.84702632
123cerebellar Purkinje cell layer development (GO:0021680)2.84585479
124neuromuscular synaptic transmission (GO:0007274)2.81429163
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.79868715
126regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.78914495
127acidic amino acid transport (GO:0015800)2.77029510
128axon ensheathment in central nervous system (GO:0032291)2.75666523
129central nervous system myelination (GO:0022010)2.75666523
130positive regulation of synapse assembly (GO:0051965)2.71950493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.23689075
2GBX2_23144817_ChIP-Seq_PC3_Human3.58717791
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01138378
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96262321
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93550310
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57948560
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57948560
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49430246
9REST_21632747_ChIP-Seq_MESCs_Mouse2.47668429
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47422795
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47340889
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38435943
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36734936
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35602671
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.34836577
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33005604
17DROSHA_22980978_ChIP-Seq_HELA_Human2.30856882
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.20410127
19AR_21572438_ChIP-Seq_LNCaP_Human2.12666161
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.11642950
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.08940997
22TAF15_26573619_Chip-Seq_HEK293_Human2.04173178
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99449040
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.95727029
25* REST_18959480_ChIP-ChIP_MESCs_Mouse1.94101001
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84522577
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82205658
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.78646408
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.76971690
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73637521
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73580875
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71497234
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71319419
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70552197
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66264678
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65654237
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64118891
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60483140
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59267092
40P300_19829295_ChIP-Seq_ESCs_Human1.54239642
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53274917
42IGF1R_20145208_ChIP-Seq_DFB_Human1.51687472
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.50996253
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44160618
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44017928
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42683831
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41515092
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.36630200
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.36446550
50* STAT3_23295773_ChIP-Seq_U87_Human1.34612925
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33928141
52* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32870779
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.32762493
54AHR_22903824_ChIP-Seq_MCF-7_Human1.32383507
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31921897
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.30257048
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.29793447
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29681918
59SOX9_26525672_Chip-Seq_HEART_Mouse1.27251967
60* AR_25329375_ChIP-Seq_VCAP_Human1.27219330
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.26909151
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25809301
63AR_19668381_ChIP-Seq_PC3_Human1.25776040
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23720174
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23640388
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22330245
67* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20725684
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20584628
69ZNF274_21170338_ChIP-Seq_K562_Hela1.19337083
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19321286
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18773884
72TP53_16413492_ChIP-PET_HCT116_Human1.18569458
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18234144
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.17742278
75TCF4_23295773_ChIP-Seq_U87_Human1.17157259
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16334224
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14365339
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.13271113
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13031216
80* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12850617
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11398816
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09738836
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08543807
84* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08410625
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07959117
86KDM2B_26808549_Chip-Seq_K562_Human1.06354043
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.05743391
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05301077
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04646078
90ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04601216
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04171850
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04171850
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04138892
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02836084
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.02750400
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02467964
97* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02433714
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02046029
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01970492
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.01117871
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01084095
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00776367
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00293479
104RXR_22108803_ChIP-Seq_LS180_Human1.00142849
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00056703
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99776619
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99099718
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.98783838
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.98383585
110TP53_18474530_ChIP-ChIP_U2OS_Human0.97814927
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97737871
112FUS_26573619_Chip-Seq_HEK293_Human0.97181982
113* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97016209
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96833998
115RNF2_27304074_Chip-Seq_NSC_Mouse0.96830502
116CBX2_27304074_Chip-Seq_ESCs_Mouse0.96630062
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.96510769
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95930153
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94947235
120* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94932978
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94125389
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94008008
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93221933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.87131244
2MP0003880_abnormal_central_pattern5.08035849
3MP0004270_analgesia4.06909655
4MP0003635_abnormal_synaptic_transmissio4.02402148
5MP0009046_muscle_twitch3.83080337
6MP0009745_abnormal_behavioral_response3.35717024
7MP0001968_abnormal_touch/_nociception3.24399397
8MP0002063_abnormal_learning/memory/cond3.16965695
9MP0002064_seizures3.12557111
10MP0002735_abnormal_chemical_nociception2.91166763
11MP0002272_abnormal_nervous_system2.79448820
12MP0002734_abnormal_mechanical_nocicepti2.79149388
13MP0005423_abnormal_somatic_nervous2.78648709
14MP0001486_abnormal_startle_reflex2.69562676
15MP0002572_abnormal_emotion/affect_behav2.66909287
16MP0002736_abnormal_nociception_after2.60765203
17MP0002822_catalepsy2.51930614
18MP0004858_abnormal_nervous_system2.40649318
19MP0002733_abnormal_thermal_nociception2.27726868
20MP0001501_abnormal_sleep_pattern2.17589728
21MP0002067_abnormal_sensory_capabilities2.16846096
22MP0001970_abnormal_pain_threshold2.08013569
23MP0001440_abnormal_grooming_behavior2.06400772
24MP0002184_abnormal_innervation2.05537021
25MP0008569_lethality_at_weaning1.96301550
26MP0006276_abnormal_autonomic_nervous1.91339682
27MP0000778_abnormal_nervous_system1.90261307
28MP0003329_amyloid_beta_deposits1.81768619
29MP0004811_abnormal_neuron_physiology1.78028269
30MP0004924_abnormal_behavior1.73778750
31MP0005386_behavior/neurological_phenoty1.73778750
32MP0001348_abnormal_lacrimal_gland1.73281039
33MP0000955_abnormal_spinal_cord1.72984816
34MP0000569_abnormal_digit_pigmentation1.71108345
35MP0004142_abnormal_muscle_tone1.66100458
36MP0002557_abnormal_social/conspecific_i1.60891384
37MP0004084_abnormal_cardiac_muscle1.55188956
38MP0001984_abnormal_olfaction1.53950392
39MP0004215_abnormal_myocardial_fiber1.52319589
40MP0009780_abnormal_chondrocyte_physiolo1.46736442
41MP0002882_abnormal_neuron_morphology1.46241174
42* MP0002066_abnormal_motor_capabilities/c1.43694393
43MP0003787_abnormal_imprinting1.41244138
44MP0003633_abnormal_nervous_system1.35904241
45MP0004885_abnormal_endolymph1.31508098
46MP0003879_abnormal_hair_cell1.31150395
47MP0005623_abnormal_meninges_morphology1.29828997
48MP0001529_abnormal_vocalization1.28662389
49MP0002909_abnormal_adrenal_gland1.28210962
50MP0005645_abnormal_hypothalamus_physiol1.27998393
51MP0005646_abnormal_pituitary_gland1.24777859
52MP0003631_nervous_system_phenotype1.23942949
53MP0001188_hyperpigmentation1.19527276
54MP0004510_myositis1.18819957
55MP0008872_abnormal_physiological_respon1.18716147
56MP0002254_reproductive_system_inflammat1.15967964
57MP0004036_abnormal_muscle_relaxation1.14603913
58MP0001502_abnormal_circadian_rhythm1.07249097
59MP0002152_abnormal_brain_morphology1.07097557
60MP0003123_paternal_imprinting1.06344755
61MP0003632_abnormal_nervous_system1.05813750
62MP0000920_abnormal_myelination1.05628634
63MP0000604_amyloidosis1.04789469
64MP0002229_neurodegeneration1.02389155
65MP0008874_decreased_physiological_sensi0.98256148
66MP0003634_abnormal_glial_cell0.97679512
67MP0000579_abnormal_nail_morphology0.97129633
68MP0004742_abnormal_vestibular_system0.96256022
69MP0004145_abnormal_muscle_electrophysio0.95627821
70MP0000749_muscle_degeneration0.95163209
71MP0002638_abnormal_pupillary_reflex0.93224015
72MP0002009_preneoplasia0.90743988
73MP0005620_abnormal_muscle_contractility0.88111680
74MP0003122_maternal_imprinting0.87475782
75MP0001905_abnormal_dopamine_level0.87437340
76MP0001299_abnormal_eye_distance/0.86574716
77MP0003283_abnormal_digestive_organ0.86330999
78MP0002972_abnormal_cardiac_muscle0.86088563
79MP0001346_abnormal_lacrimal_gland0.85852466
80MP0004484_altered_response_of0.83857105
81MP0010386_abnormal_urinary_bladder0.82472645
82MP0002752_abnormal_somatic_nervous0.81904547
83MP0001177_atelectasis0.81762820
84MP0002069_abnormal_eating/drinking_beha0.81415848
85MP0003690_abnormal_glial_cell0.79634470
86MP0001963_abnormal_hearing_physiology0.78843223
87MP0003045_fibrosis0.78159173
88MP0003121_genomic_imprinting0.77429269
89MP0000751_myopathy0.75461322
90MP0002234_abnormal_pharynx_morphology0.74474900
91MP0004087_abnormal_muscle_fiber0.72164599
92MP0005535_abnormal_body_temperature0.71997861
93MP0001485_abnormal_pinna_reflex0.71974751
94MP0002138_abnormal_hepatobiliary_system0.71640740
95MP0000566_synostosis0.71348945
96MP0006292_abnormal_olfactory_placode0.70876817
97MP0005187_abnormal_penis_morphology0.70816938
98MP0003136_yellow_coat_color0.68307718
99MP0004085_abnormal_heartbeat0.67377799
100MP0002751_abnormal_autonomic_nervous0.67001697
101MP0002837_dystrophic_cardiac_calcinosis0.66746957
102MP0005394_taste/olfaction_phenotype0.65866602
103MP0005499_abnormal_olfactory_system0.65866602
104MP0008877_abnormal_DNA_methylation0.65612724
105MP0005551_abnormal_eye_electrophysiolog0.64914766
106MP0000534_abnormal_ureter_morphology0.64230047
107MP0010030_abnormal_orbit_morphology0.62640318
108MP0006138_congestive_heart_failure0.61821020
109MP0002081_perinatal_lethality0.61460176
110MP0002876_abnormal_thyroid_physiology0.58692399
111MP0000013_abnormal_adipose_tissue0.58641379
112MP0005171_absent_coat_pigmentation0.57488611
113MP0001943_abnormal_respiration0.56832995
114MP0003861_abnormal_nervous_system0.56347217
115MP0003137_abnormal_impulse_conducting0.52654073
116* MP0010769_abnormal_survival0.52480860
117* MP0002082_postnatal_lethality0.52045845
118* MP0010770_preweaning_lethality0.52045845
119* MP0010768_mortality/aging0.48506420
120MP0010234_abnormal_vibrissa_follicle0.46649863
121MP0001986_abnormal_taste_sensitivity0.45277937
122MP0005409_darkened_coat_color0.45116825
123MP0003956_abnormal_body_size0.44099774
124MP0003075_altered_response_to0.43985976

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.59904129
2Myokymia (HP:0002411)7.14817109
3Focal seizures (HP:0007359)5.78112708
4Atonic seizures (HP:0010819)5.22325003
5Febrile seizures (HP:0002373)5.20117581
6Action tremor (HP:0002345)5.15543867
7Epileptic encephalopathy (HP:0200134)4.80469308
8Progressive cerebellar ataxia (HP:0002073)4.59381685
9Visual hallucinations (HP:0002367)4.39424396
10Absence seizures (HP:0002121)4.28051272
11Dialeptic seizures (HP:0011146)3.87893867
12Supranuclear gaze palsy (HP:0000605)3.80747190
13Generalized tonic-clonic seizures (HP:0002069)3.71226859
14Gaze-evoked nystagmus (HP:0000640)3.53727903
15Impaired vibration sensation in the lower limbs (HP:0002166)3.52358608
16Limb dystonia (HP:0002451)3.44722089
17Ulnar claw (HP:0001178)3.42887829
18Urinary bladder sphincter dysfunction (HP:0002839)3.38068627
19Ankle clonus (HP:0011448)3.31899122
20Scanning speech (HP:0002168)3.30646914
21Truncal ataxia (HP:0002078)3.30123221
22Termporal pattern (HP:0011008)3.28985382
23Insidious onset (HP:0003587)3.28985382
24Sudden death (HP:0001699)3.25000879
25Dysdiadochokinesis (HP:0002075)3.23301146
26Bundle branch block (HP:0011710)3.22072405
27Abnormality of the corticospinal tract (HP:0002492)3.20646215
28Urinary urgency (HP:0000012)3.15794728
29Dysmetria (HP:0001310)3.14264937
30Broad-based gait (HP:0002136)3.04736789
31Poor eye contact (HP:0000817)3.02016993
32Spastic gait (HP:0002064)3.00891054
33Hemiplegia (HP:0002301)2.90337289
34Impaired social interactions (HP:0000735)2.90240851
35Abnormal social behavior (HP:0012433)2.90240851
36Hyperventilation (HP:0002883)2.85149621
37Pheochromocytoma (HP:0002666)2.83909794
38Depression (HP:0000716)2.77181717
39Postural instability (HP:0002172)2.75283832
40Amblyopia (HP:0000646)2.73731194
41Impaired smooth pursuit (HP:0007772)2.67425214
42Hemiparesis (HP:0001269)2.64835905
43Genetic anticipation (HP:0003743)2.63190393
44Excessive salivation (HP:0003781)2.56904891
45Drooling (HP:0002307)2.56904891
46Abnormal eating behavior (HP:0100738)2.56369744
47Intention tremor (HP:0002080)2.54283399
48Atrial fibrillation (HP:0005110)2.52222768
49Anxiety (HP:0000739)2.51842879
50Lower limb muscle weakness (HP:0007340)2.51310992
51Absent speech (HP:0001344)2.50396669
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.50200395
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50200395
54Abnormality of the lower motor neuron (HP:0002366)2.48479765
55Hammertoe (HP:0001765)2.45297388
56Neuroendocrine neoplasm (HP:0100634)2.44413853
57Primary atrial arrhythmia (HP:0001692)2.40343670
58Torticollis (HP:0000473)2.39712928
59Bradykinesia (HP:0002067)2.38231062
60Status epilepticus (HP:0002133)2.37522895
61Impaired vibratory sensation (HP:0002495)2.35163338
62Syncope (HP:0001279)2.33391580
63Epileptiform EEG discharges (HP:0011182)2.32850964
64Supraventricular arrhythmia (HP:0005115)2.30681342
65Supraventricular tachycardia (HP:0004755)2.30361690
66Dysmetric saccades (HP:0000641)2.28427667
67Abnormality of ocular smooth pursuit (HP:0000617)2.25709181
68Progressive inability to walk (HP:0002505)2.24998132
69EEG with generalized epileptiform discharges (HP:0011198)2.24140765
70Neurofibrillary tangles (HP:0002185)2.23758275
71Heart block (HP:0012722)2.22056728
72Cerebral inclusion bodies (HP:0100314)2.19849661
73Aqueductal stenosis (HP:0002410)2.17877458
74Fetal akinesia sequence (HP:0001989)2.15544616
75Hypsarrhythmia (HP:0002521)2.13317407
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.13231916
77Abnormality of binocular vision (HP:0011514)2.12758696
78Diplopia (HP:0000651)2.12758696
79Onion bulb formation (HP:0003383)2.12136622
80Focal dystonia (HP:0004373)2.11893161
81Tetraplegia (HP:0002445)2.09667159
82Mutism (HP:0002300)2.08666814
83Lower limb amyotrophy (HP:0007210)2.06538581
84Insomnia (HP:0100785)2.05666509
85Cerebral hypomyelination (HP:0006808)2.05507858
86Split foot (HP:0001839)2.05374445
87Stereotypic behavior (HP:0000733)2.05005171
88Neoplasm of the peripheral nervous system (HP:0100007)2.03676575
89Resting tremor (HP:0002322)2.02436894
90Sleep apnea (HP:0010535)2.00710157
91Abnormal atrioventricular conduction (HP:0005150)2.00559158
92Obstructive sleep apnea (HP:0002870)1.97686890
93Paraplegia (HP:0010550)1.96267081
94Decreased motor nerve conduction velocity (HP:0003431)1.95569118
95Pointed chin (HP:0000307)1.94183049
96Postural tremor (HP:0002174)1.93788057
97Craniofacial dystonia (HP:0012179)1.93776856
98Ventricular fibrillation (HP:0001663)1.91522432
99Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.91288745
100Gait ataxia (HP:0002066)1.90969829
101Annular pancreas (HP:0001734)1.90677812
102Generalized myoclonic seizures (HP:0002123)1.89837504
103Prolonged QT interval (HP:0001657)1.89282352
104Megalencephaly (HP:0001355)1.88631375
105Papilledema (HP:0001085)1.88506447
106Incomplete penetrance (HP:0003829)1.88215649
107Clonus (HP:0002169)1.87095667
108Steppage gait (HP:0003376)1.86432218
109Atrioventricular block (HP:0001678)1.85486920
110Spastic paraplegia (HP:0001258)1.85124968
111Turricephaly (HP:0000262)1.85017344
112Hypoventilation (HP:0002791)1.83606613
113Morphological abnormality of the pyramidal tract (HP:0002062)1.83199172
114Abnormality of saccadic eye movements (HP:0000570)1.83005692
115Abnormality of the periventricular white matter (HP:0002518)1.82412475
116Distal sensory impairment (HP:0002936)1.82156250
117Aplasia involving bones of the extremities (HP:0009825)1.81970184
118Aplasia involving bones of the upper limbs (HP:0009823)1.81970184
119Aplasia of the phalanges of the hand (HP:0009802)1.81970184
120Peripheral hypomyelination (HP:0007182)1.81453419
121Subaortic stenosis (HP:0001682)1.81412576
122Abnormality of the left ventricular outflow tract (HP:0011103)1.81412576
123Akinesia (HP:0002304)1.80030077
124Myotonia (HP:0002486)1.79888480
125Blue irides (HP:0000635)1.79792427
126EMG: neuropathic changes (HP:0003445)1.79122160
127Hyporeflexia of lower limbs (HP:0002600)1.75696720
128Apathy (HP:0000741)1.73819704
129Abnormality of the calf musculature (HP:0001430)1.72252314
130Exercise-induced muscle cramps (HP:0003710)1.72162146
131Amyotrophic lateral sclerosis (HP:0007354)1.70966506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.81186794
2EPHA44.02461863
3MAP3K93.77647879
4MAP3K43.08360306
5MINK13.07238531
6CASK2.50691118
7MAP2K72.32450615
8MARK12.21976462
9KSR22.18559472
10RIPK42.18172979
11PAK62.11363713
12MAP3K132.04071600
13MAP2K41.97744069
14NTRK11.97428750
15MAP3K121.91863763
16NEK11.87969856
17DAPK21.86175802
18NTRK21.78119878
19KSR11.62463638
20CAMKK11.56412989
21WNK11.52315251
22CDK51.50617243
23PNCK1.40800551
24PLK21.30796113
25PRKD31.29437471
26MAPK131.29396248
27ARAF1.29061750
28LATS21.26034271
29RET1.24809310
30PRPF4B1.20974484
31LMTK21.20842784
32SIK21.20158949
33SGK2231.19944138
34SGK4941.19944138
35STK381.19578299
36CAMKK21.16336328
37SGK21.15997952
38TNIK1.15794951
39GRK51.13050840
40MAP3K21.10721564
41PHKG11.09505309
42PHKG21.09505309
43PRKCG1.08590550
44TYRO31.08210757
45DAPK11.05490770
46BMPR20.98157799
47SGK30.97498480
48CDK190.96445824
49STK110.93407964
50DMPK0.93315625
51OBSCN0.92654959
52CAMK2A0.90613826
53SGK10.90199970
54LIMK10.88731794
55FES0.85141258
56SCYL20.83986904
57UHMK10.83438300
58PAK30.80047198
59MAPK120.79949535
60RIPK10.79878246
61DYRK20.76599394
62RAF10.70514090
63PTK2B0.70434828
64CDK180.67866848
65PKN10.66671143
66PDGFRA0.65187628
67CDK140.65064214
68FER0.64106773
69CDK150.64037735
70TNK20.63268969
71AKT30.63046624
72PRKCH0.62958496
73FGR0.62371339
74MYLK0.61932635
75SIK30.61928725
76PRKCZ0.61787833
77CDC42BPA0.60949256
78PINK10.60625264
79BCR0.59805129
80TTN0.59469650
81PRKCE0.58384188
82BRSK10.58380219
83EPHB20.56913245
84ALK0.56811374
85CAMK2B0.56456378
86OXSR10.55409849
87FGFR20.55200548
88RPS6KA30.54956763
89MAPK100.54585642
90MAP2K10.54261991
91PDPK10.53931065
92CAMK2G0.53263265
93ROCK10.52348317
94BRAF0.52026953
95CAMK1G0.52019788
96CDK11A0.51008489
97PDK10.50857364
98DYRK1A0.50059311
99ROCK20.49920982
100CAMK10.49363338
101CSNK1G30.49046472
102STK390.48842740
103NEK60.47639640
104CCNB10.46940579
105MAPKAPK50.46544156
106MAP3K10.46063518
107MARK20.45652730
108TIE10.44315162
109ADRBK10.43764534
110CSNK1G10.42655186
111DAPK30.42547303
112CSNK1A1L0.40976685
113PRKCB0.39752712
114PRKG10.39039959
115CSNK1G20.38872960
116CAMK2D0.36464393
117CSNK1D0.36390984
118FYN0.35589297
119CAMK40.34240715
120MAP3K140.34167358
121RPS6KA20.34115181
122CSNK1E0.32993440
123DDR20.32732875
124MAPK80.32460939
125MOS0.32007362
126PRKDC0.31809091
127WNK30.30020482

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57827168
2Synaptic vesicle cycle_Homo sapiens_hsa047212.99911531
3Olfactory transduction_Homo sapiens_hsa047402.76770831
4GABAergic synapse_Homo sapiens_hsa047272.59933172
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56802194
6Circadian entrainment_Homo sapiens_hsa047132.54129368
7Glutamatergic synapse_Homo sapiens_hsa047242.52978528
8Long-term potentiation_Homo sapiens_hsa047202.51216977
9Morphine addiction_Homo sapiens_hsa050322.45730286
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23023050
11Amphetamine addiction_Homo sapiens_hsa050312.22015717
12Dopaminergic synapse_Homo sapiens_hsa047282.08311481
13Salivary secretion_Homo sapiens_hsa049702.08126482
14Taste transduction_Homo sapiens_hsa047421.93882114
15Cholinergic synapse_Homo sapiens_hsa047251.88480583
16Gastric acid secretion_Homo sapiens_hsa049711.79816332
17Insulin secretion_Homo sapiens_hsa049111.74361443
18Renin secretion_Homo sapiens_hsa049241.73177628
19Long-term depression_Homo sapiens_hsa047301.70558737
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67335066
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67298985
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65510879
23Serotonergic synapse_Homo sapiens_hsa047261.65153965
24Oxytocin signaling pathway_Homo sapiens_hsa049211.60563681
25Calcium signaling pathway_Homo sapiens_hsa040201.47982164
26Cocaine addiction_Homo sapiens_hsa050301.47174515
27GnRH signaling pathway_Homo sapiens_hsa049121.45623448
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39739291
29Gap junction_Homo sapiens_hsa045401.34062820
30Nitrogen metabolism_Homo sapiens_hsa009101.32111592
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28123022
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27293635
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26097778
34cAMP signaling pathway_Homo sapiens_hsa040241.24784611
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21164445
36Type II diabetes mellitus_Homo sapiens_hsa049301.17454562
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16719850
38Axon guidance_Homo sapiens_hsa043601.16674041
39Estrogen signaling pathway_Homo sapiens_hsa049151.15056773
40Glioma_Homo sapiens_hsa052141.12847969
41ErbB signaling pathway_Homo sapiens_hsa040121.11890275
42Dorso-ventral axis formation_Homo sapiens_hsa043201.10202218
43Collecting duct acid secretion_Homo sapiens_hsa049661.09342374
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05476568
45Melanogenesis_Homo sapiens_hsa049161.03740323
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01264216
47Vitamin B6 metabolism_Homo sapiens_hsa007500.99745055
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89862559
49Cardiac muscle contraction_Homo sapiens_hsa042600.88979678
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.86263119
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.86229966
52MAPK signaling pathway_Homo sapiens_hsa040100.84994313
53Oocyte meiosis_Homo sapiens_hsa041140.83324177
54Hippo signaling pathway_Homo sapiens_hsa043900.82395001
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79118967
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78161383
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.77315421
58Alzheimers disease_Homo sapiens_hsa050100.76101116
59Dilated cardiomyopathy_Homo sapiens_hsa054140.75118692
60Choline metabolism in cancer_Homo sapiens_hsa052310.74192019
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72399431
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72178711
63Thyroid hormone synthesis_Homo sapiens_hsa049180.71855056
64Pancreatic secretion_Homo sapiens_hsa049720.70893961
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69860867
66Tight junction_Homo sapiens_hsa045300.65932421
67Ras signaling pathway_Homo sapiens_hsa040140.64791945
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64766111
69Hedgehog signaling pathway_Homo sapiens_hsa043400.64269206
70Phototransduction_Homo sapiens_hsa047440.63679429
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62806739
72Vibrio cholerae infection_Homo sapiens_hsa051100.61188841
73VEGF signaling pathway_Homo sapiens_hsa043700.58929566
74Bile secretion_Homo sapiens_hsa049760.58455715
75Rap1 signaling pathway_Homo sapiens_hsa040150.58303747
76Inositol phosphate metabolism_Homo sapiens_hsa005620.56114854
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.55334083
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54305927
79Circadian rhythm_Homo sapiens_hsa047100.54238658
80Parkinsons disease_Homo sapiens_hsa050120.53488257
81Glucagon signaling pathway_Homo sapiens_hsa049220.53289661
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52454891
83mTOR signaling pathway_Homo sapiens_hsa041500.51938963
84Prion diseases_Homo sapiens_hsa050200.48000114
85ECM-receptor interaction_Homo sapiens_hsa045120.47997059
86African trypanosomiasis_Homo sapiens_hsa051430.47716988
87Alcoholism_Homo sapiens_hsa050340.47257085
88Chemokine signaling pathway_Homo sapiens_hsa040620.47180231
89Adherens junction_Homo sapiens_hsa045200.46930882
90Type I diabetes mellitus_Homo sapiens_hsa049400.46849318
91Basal cell carcinoma_Homo sapiens_hsa052170.46394409
92Insulin signaling pathway_Homo sapiens_hsa049100.45284809
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44165500
94Arginine and proline metabolism_Homo sapiens_hsa003300.44000325
95Endometrial cancer_Homo sapiens_hsa052130.43579565
96Ovarian steroidogenesis_Homo sapiens_hsa049130.43519128
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43441714
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42985856
99Non-small cell lung cancer_Homo sapiens_hsa052230.42355676
100Endocytosis_Homo sapiens_hsa041440.42186022
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40639783
102Focal adhesion_Homo sapiens_hsa045100.39209111
103Wnt signaling pathway_Homo sapiens_hsa043100.37641470
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36867799
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35669873
106Melanoma_Homo sapiens_hsa052180.35288052
107Renal cell carcinoma_Homo sapiens_hsa052110.35286641
108Protein digestion and absorption_Homo sapiens_hsa049740.33141298
109Prolactin signaling pathway_Homo sapiens_hsa049170.31444890
110Fatty acid biosynthesis_Homo sapiens_hsa000610.30988594
111Oxidative phosphorylation_Homo sapiens_hsa001900.30393633
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29901038
113AMPK signaling pathway_Homo sapiens_hsa041520.28850187
114Huntingtons disease_Homo sapiens_hsa050160.28183278
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27896539
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27859805
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25590984
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25169267

Most similar genes based on co-expression Upload to Enrichr

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