ADAM28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1xenobiotic catabolic process (GO:0042178)9.93769266
2response to nitrosative stress (GO:0051409)8.65497181
3one-carbon compound transport (GO:0019755)8.20332377
4regulation of skeletal muscle contraction (GO:0014819)6.13382281
5cellular glucuronidation (GO:0052695)6.08596745
6glucuronate metabolic process (GO:0019585)6.05630248
7uronic acid metabolic process (GO:0006063)6.05630248
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.65170765
9immunoglobulin mediated immune response (GO:0016064)5.55140122
10nucleotide transmembrane transport (GO:1901679)5.42696810
11positive regulation of gamma-delta T cell activation (GO:0046645)5.26482597
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.96223102
13negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.67968850
14positive regulation of type 2 immune response (GO:0002830)4.64041807
15glutathione derivative metabolic process (GO:1901685)4.58270946
16glutathione derivative biosynthetic process (GO:1901687)4.58270946
17regulation of B cell receptor signaling pathway (GO:0050855)4.52892960
18cell wall macromolecule catabolic process (GO:0016998)4.49401995
19regulation of antigen processing and presentation (GO:0002577)4.45767141
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.42859636
21negative regulation of cell killing (GO:0031342)4.42859636
22antigen processing and presentation of endogenous antigen (GO:0019883)4.33384026
23B cell receptor signaling pathway (GO:0050853)4.31778772
24positive regulation of antigen processing and presentation (GO:0002579)4.28588340
25B cell mediated immunity (GO:0019724)4.24405523
26positive thymic T cell selection (GO:0045059)4.23826271
27renal absorption (GO:0070293)4.21290607
28myoblast migration (GO:0051451)4.15126602
29interferon-gamma-mediated signaling pathway (GO:0060333)4.12807596
30positive regulation of B cell differentiation (GO:0045579)4.11040815
31neutrophil activation involved in immune response (GO:0002283)4.04003092
32regulation of cardioblast proliferation (GO:0003264)3.97902805
33regulation of secondary heart field cardioblast proliferation (GO:0003266)3.97902805
34regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.97728326
35bone remodeling (GO:0046849)3.94303801
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93587476
37interleukin-6-mediated signaling pathway (GO:0070102)3.91749659
38regulation of gamma-delta T cell activation (GO:0046643)3.90099711
39hemidesmosome assembly (GO:0031581)3.82976079
40cell wall macromolecule metabolic process (GO:0044036)3.78759243
41regulation of dendritic cell antigen processing and presentation (GO:0002604)3.76856259
42gas transport (GO:0015669)3.70119429
43response to peptidoglycan (GO:0032494)3.69766711
44regulation of gamma-delta T cell differentiation (GO:0045586)3.69602815
45L-ascorbic acid metabolic process (GO:0019852)3.69505282
46replicative senescence (GO:0090399)3.68491520
47negative regulation of keratinocyte proliferation (GO:0010839)3.67805553
48regulation of germinal center formation (GO:0002634)3.65471761
49cell differentiation involved in metanephros development (GO:0072202)3.64697265
50branching involved in salivary gland morphogenesis (GO:0060445)3.63984185
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62605819
52negative regulation of interleukin-12 production (GO:0032695)3.58293366
53surfactant homeostasis (GO:0043129)3.56385082
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.55449401
55bundle of His cell to Purkinje myocyte communication (GO:0086069)3.53666469
56pharyngeal system development (GO:0060037)3.51185644
57macrophage activation involved in immune response (GO:0002281)3.49965607
58regulation of T-helper 1 cell differentiation (GO:0045625)3.49559058
59positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.48976381
60negative regulation of JUN kinase activity (GO:0043508)3.46891907
61benzene-containing compound metabolic process (GO:0042537)3.41691009
62androgen biosynthetic process (GO:0006702)3.41194954
63regulation of mast cell degranulation (GO:0043304)3.39040887
64regulation of B cell differentiation (GO:0045577)3.37405950
65positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.35526712
66positive regulation of defense response to virus by host (GO:0002230)3.34747228
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27088263
68positive T cell selection (GO:0043368)3.26304967
69defense response to protozoan (GO:0042832)3.25353617
70germinal center formation (GO:0002467)3.24707063
71regulation of mast cell activation involved in immune response (GO:0033006)3.24285750
72cellular response to exogenous dsRNA (GO:0071360)3.23410479
73regulation of mast cell activation (GO:0033003)3.23194235
74CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.22857781
75T-helper 1 type immune response (GO:0042088)3.17176684
76modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16797842
77positive regulation by organism of defense response of other organism involved in symbiotic interact3.16797842
78modulation by symbiont of host immune response (GO:0052553)3.16797842
79positive regulation by symbiont of host defense response (GO:0052509)3.16797842
80modulation by symbiont of host defense response (GO:0052031)3.16797842
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16797842
82metanephric mesenchyme development (GO:0072075)3.15129328
83production of molecular mediator of immune response (GO:0002440)3.13986204
84regulation of myeloid leukocyte mediated immunity (GO:0002886)3.13968184
85cellular response to interferon-gamma (GO:0071346)3.12805504
86generation of neurons (GO:0048699)3.11471830
87positive regulation of osteoblast proliferation (GO:0033690)3.10690515
88positive regulation of mast cell degranulation (GO:0043306)3.10569334
89positive regulation of mast cell activation involved in immune response (GO:0033008)3.10569334
90regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.10559557
91regulation of transmission of nerve impulse (GO:0051969)3.09053135
92positive regulation of toll-like receptor signaling pathway (GO:0034123)3.08262789
93facial nerve structural organization (GO:0021612)3.07456354
94negative regulation of chondrocyte differentiation (GO:0032331)3.07243857
95mesenchymal cell differentiation involved in renal system development (GO:2001012)3.06892576
96mesenchymal cell differentiation involved in kidney development (GO:0072161)3.06892576
97negative thymic T cell selection (GO:0045060)3.05953517
98chemical homeostasis within a tissue (GO:0048875)3.04990312
99regulation of interleukin-8 secretion (GO:2000482)3.04755910
100response to muramyl dipeptide (GO:0032495)3.04708583
101pyrimidine-containing compound transmembrane transport (GO:0072531)3.04579165
102positive regulation of T-helper cell differentiation (GO:0045624)3.04236264
103regulation of hypersensitivity (GO:0002883)3.03852130
104positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.03736239
105response to protozoan (GO:0001562)3.03588186
106regulation of type B pancreatic cell apoptotic process (GO:2000674)3.03000007
107regulation of phospholipase A2 activity (GO:0032429)3.02983527
108seminiferous tubule development (GO:0072520)3.00666367
109detection of external biotic stimulus (GO:0098581)3.00190825
110myeloid cell activation involved in immune response (GO:0002275)2.99900798
111positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.99626480
112detection of other organism (GO:0098543)2.99360402
113microglial cell activation (GO:0001774)2.99282031
114negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98990910
115negative regulation of T-helper cell differentiation (GO:0045623)2.98990910
116purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.98800130
1173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.98800130
118negative regulation of T cell mediated immunity (GO:0002710)2.98142708
119neutrophil mediated immunity (GO:0002446)2.97242621
120antigen receptor-mediated signaling pathway (GO:0050851)2.96370555
121detection of bacterium (GO:0016045)2.96176455
122negative regulation of fatty acid transport (GO:2000192)2.95713425
123relaxation of cardiac muscle (GO:0055119)2.95585140
124positive regulation of actin filament depolymerization (GO:0030836)2.93948862
125neutrophil activation (GO:0042119)2.93195432
126phenylpropanoid metabolic process (GO:0009698)2.91963926
127production of molecular mediator involved in inflammatory response (GO:0002532)2.91954782
128response to interferon-gamma (GO:0034341)2.90576085
129regulation of T cell mediated cytotoxicity (GO:0001914)2.89989576
130regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.89393257
131regulation of T-helper 1 type immune response (GO:0002825)2.88494493
132regulation of interferon-alpha production (GO:0032647)2.88119153
133positive regulation of mast cell activation (GO:0033005)2.86881840
134positive regulation of interferon-alpha production (GO:0032727)2.86081838
135positive regulation of T cell migration (GO:2000406)2.86071932
136dendritic cell chemotaxis (GO:0002407)2.85308426
137regulation of leukocyte degranulation (GO:0043300)2.85278407
138dentate gyrus development (GO:0021542)2.85050288
139sulfate transmembrane transport (GO:1902358)2.84533544
140negative regulation of chemokine production (GO:0032682)2.84345924
141positive regulation of interleukin-17 production (GO:0032740)2.84132573
142negative T cell selection (GO:0043383)2.84100118
143regulation of type 2 immune response (GO:0002828)2.82923316
144diterpenoid biosynthetic process (GO:0016102)2.82910728
145negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.82146649
146regulation of T cell migration (GO:2000404)2.81635830
147glutathione metabolic process (GO:0006749)2.81593621
148superoxide anion generation (GO:0042554)2.81536039
149G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.80386475
150negative regulation of leukocyte mediated immunity (GO:0002704)2.79968254
151energy homeostasis (GO:0097009)2.79897585
152nucleotide transport (GO:0006862)2.78408305
153interferon-gamma secretion (GO:0072643)2.78267758
154poly(A)+ mRNA export from nucleus (GO:0016973)2.78088006
155mast cell activation (GO:0045576)2.78044302
156type I interferon signaling pathway (GO:0060337)2.77996979
157cellular response to type I interferon (GO:0071357)2.77996979
158response to type I interferon (GO:0034340)2.77509683
159response to host immune response (GO:0052572)2.76740599
160response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76740599
161response to caffeine (GO:0031000)2.76587615
162response to interferon-beta (GO:0035456)2.76503231
163granulocyte activation (GO:0036230)2.75353336
164negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.75010709
165regulation of interleukin-12 production (GO:0032655)2.74784955
166regulation of T-helper cell differentiation (GO:0045622)2.74558123
167negative regulation of lymphocyte mediated immunity (GO:0002707)2.74360347
168regulation of T-helper 2 cell differentiation (GO:0045628)2.72474283
169detection of biotic stimulus (GO:0009595)2.71715025
170kidney morphogenesis (GO:0060993)2.71615545
171regulation of alpha-beta T cell proliferation (GO:0046640)2.71582772
172positive regulation of chemokine secretion (GO:0090197)2.71398358
173regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.71172304
174regulation of interferon-beta biosynthetic process (GO:0045357)2.70923057
175positive regulation of B cell activation (GO:0050871)2.70714767
176regulation of cell proliferation involved in kidney development (GO:1901722)2.70202141
177T cell selection (GO:0045058)2.69922645
178negative regulation of gluconeogenesis (GO:0045721)2.66564786
179DNA damage response, detection of DNA damage (GO:0042769)2.66262745
180positive regulation of cellular amide metabolic process (GO:0034250)2.66128488
181kidney mesenchyme development (GO:0072074)2.63629194
182positive regulation of steroid biosynthetic process (GO:0010893)2.62233632
183cell proliferation involved in kidney development (GO:0072111)2.61947892
184desmosome organization (GO:0002934)2.61582034
185sulfate transport (GO:0008272)2.61118340
186regulation of chemokine secretion (GO:0090196)2.60510876
187androgen metabolic process (GO:0008209)2.59136514
188mesenchyme morphogenesis (GO:0072132)2.58496675
189lipoxygenase pathway (GO:0019372)2.56191150
190regulation of immunoglobulin secretion (GO:0051023)2.53161849
191polyol transport (GO:0015791)2.51745977
192organ or tissue specific immune response (GO:0002251)2.51649822
193cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.51649069
194negative regulation of lipid storage (GO:0010888)2.50147574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.79733409
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.62191344
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.39130452
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.32981342
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.09183660
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.71822540
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.41028182
8SCL_19346495_ChIP-Seq_HPC-7_Human3.40685767
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.36907595
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.17825797
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.94008995
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88867437
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.84874677
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.74723642
15MYB_26560356_Chip-Seq_TH2_Human2.42875767
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.38733292
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.28725585
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24683955
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.22959649
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20518502
21* SPI1_23547873_ChIP-Seq_NB4_Human2.18899312
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17574576
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07625818
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01315767
25SPI1_23127762_ChIP-Seq_K562_Human2.00903558
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.00838651
27TAF15_26573619_Chip-Seq_HEK293_Human1.99601798
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94428607
29* VDR_24787735_ChIP-Seq_THP-1_Human1.93940186
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85437460
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82034826
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81524416
33TP53_18474530_ChIP-ChIP_U2OS_Human1.81318513
34* VDR_24763502_ChIP-Seq_THP-1_Human1.78458166
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.77618577
36GATA3_27048872_Chip-Seq_THYMUS_Human1.76517848
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.75713017
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.75713017
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75059733
40GATA3_26560356_Chip-Seq_TH2_Human1.73305361
41MYB_26560356_Chip-Seq_TH1_Human1.71000444
42AHR_22903824_ChIP-Seq_MCF-7_Human1.66740964
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65953101
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62221459
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62192553
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62167712
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60072121
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59254294
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59186734
50CDX2_20551321_ChIP-Seq_CACO-2_Human1.55704987
51GATA1_22025678_ChIP-Seq_K562_Human1.54235720
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.53386237
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53262411
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53262411
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52816823
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52676510
57SOX2_20726797_ChIP-Seq_SW620_Human1.49880326
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.49646775
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47604354
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46785829
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.46627063
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45574058
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45229083
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43450967
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.42245914
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41470393
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41201918
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39513441
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38988131
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37824263
71GBX2_23144817_ChIP-Seq_PC3_Human1.36838225
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36648574
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34241212
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33584793
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33330213
76STAT1_20625510_ChIP-Seq_HELA_Human1.32270648
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32004243
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.31286252
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30617136
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.30282633
81MAF_26560356_Chip-Seq_TH1_Human1.24440125
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.24018951
83CJUN_26792858_Chip-Seq_BT549_Human1.23323030
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22672220
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19781833
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.19229116
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18737918
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.17865416
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17378212
90VDR_22108803_ChIP-Seq_LS180_Human1.16980066
91* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16868132
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.16217439
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16171352
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15536211
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.15191826
96GATA1_19941827_ChIP-Seq_MEL_Mouse1.15101091
97* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14466192
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14092730
99* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11352634
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.11302487
101UTX_26944678_Chip-Seq_JUKART_Human1.10693097
102SMRT_27268052_Chip-Seq_Bcells_Human1.09963777
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.09637206
104P53_22387025_ChIP-Seq_ESCs_Mouse1.07387278
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.06965411
106PU_27001747_Chip-Seq_BMDM_Mouse1.06863858
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06773816
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06631120
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06631120
110CIITA_25753668_ChIP-Seq_RAJI_Human1.05714673
111STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05663523
112POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04282011
113RNF2_27304074_Chip-Seq_NSC_Mouse1.03924913
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.03856732
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.03836935
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03290813
117ZFX_18555785_Chip-Seq_ESCs_Mouse1.02450399
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02164116
119P300_19829295_ChIP-Seq_ESCs_Human1.01557604
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.01049543
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00700495
122MYC_22102868_ChIP-Seq_BL_Human1.00157313
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.00010116
124* KLF5_25053715_ChIP-Seq_YYC3_Human0.99189143
125* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98478608
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96402157
127GATA1_19941826_ChIP-Seq_K562_Human0.95978521
128ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95893808
129EWS_26573619_Chip-Seq_HEK293_Human0.95443157
130VDR_21846776_ChIP-Seq_THP-1_Human0.94875306
131RUNX_20019798_ChIP-Seq_JUKART_Human0.94827564
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94479233
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.94078644
134LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94077494
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93877029
136PU1_27457419_Chip-Seq_LIVER_Mouse0.92768284
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92490970
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91669048
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.91645718
140SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91295757
141ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91022558
142EED_16625203_ChIP-ChIP_MESCs_Mouse0.90939781
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90615129
144KLF4_18555785_Chip-Seq_ESCs_Mouse0.90282028
145P300_18555785_Chip-Seq_ESCs_Mouse0.89684365
146KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89416327
147KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89416327
148KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89416327
149GATA4_25053715_ChIP-Seq_YYC3_Human0.88680816
150CTCF_18555785_Chip-Seq_ESCs_Mouse0.87910217
151FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86986885
152AR_21572438_ChIP-Seq_LNCaP_Human0.86860012
153IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86430749
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86272992
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85105147
156* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85100141
157GATA3_24758297_ChIP-Seq_MCF-7_Human0.83030907
158TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82637284
159GATA2_19941826_ChIP-Seq_K562_Human0.82492609
160CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81837294
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80479984
162GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79725658
163PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78315598
164TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76532915
165CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75165726
166ER_23166858_ChIP-Seq_MCF-7_Human0.74666258
167SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.74510072
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.73984593
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73569760
170RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73333574
171TCF7_22412390_ChIP-Seq_EML_Mouse0.73067149
172GATA3_26560356_Chip-Seq_TH1_Human0.72696386
173PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71039467
174BCL6_27268052_Chip-Seq_Bcells_Human0.70605899
175TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68432383
176P300_27268052_Chip-Seq_Bcells_Human0.67428619
177CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66594667
178FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65246888
179MAF_26560356_Chip-Seq_TH2_Human0.65067596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium4.89171048
2MP0005394_taste/olfaction_phenotype4.30968433
3MP0005499_abnormal_olfactory_system4.30968433
4MP0010030_abnormal_orbit_morphology4.02661874
5MP0002254_reproductive_system_inflammat3.90961229
6MP0003303_peritoneal_inflammation3.76855084
7MP0002877_abnormal_melanocyte_morpholog3.72461748
8MP0000566_synostosis3.51925352
9MP0001346_abnormal_lacrimal_gland3.48645524
10MP0000678_abnormal_parathyroid_gland3.33896020
11MP0001800_abnormal_humoral_immune3.04374673
12MP0002148_abnormal_hypersensitivity_rea3.03919297
13MP0005671_abnormal_response_to3.01330200
14MP0003436_decreased_susceptibility_to2.94491403
15MP0000762_abnormal_tongue_morphology2.80669876
16MP0005000_abnormal_immune_tolerance2.79416996
17MP0003172_abnormal_lysosome_physiology2.74122663
18MP0006292_abnormal_olfactory_placode2.68303612
19MP0002452_abnormal_antigen_presenting2.65380876
20MP0002723_abnormal_immune_serum2.60579894
21MP0008875_abnormal_xenobiotic_pharmacok2.54905084
22MP0000685_abnormal_immune_system2.50902326
23MP0005025_abnormal_response_to2.47856559
24MP0003191_abnormal_cellular_cholesterol2.38383133
25MP0001984_abnormal_olfaction2.35760632
26MP0002420_abnormal_adaptive_immunity2.34212606
27MP0001819_abnormal_immune_cell2.34166487
28MP0005464_abnormal_platelet_physiology2.22619547
29MP0003186_abnormal_redox_activity2.17897120
30MP0009278_abnormal_bone_marrow2.14615863
31MP0004264_abnormal_extraembryonic_tissu1.98726755
32MP0002277_abnormal_respiratory_mucosa1.97909355
33MP0005397_hematopoietic_system_phenotyp1.95878414
34MP0001545_abnormal_hematopoietic_system1.95878414
35MP0000613_abnormal_salivary_gland1.89127371
36MP0000465_gastrointestinal_hemorrhage1.85424639
37MP0000716_abnormal_immune_system1.81729787
38MP0003763_abnormal_thymus_physiology1.81039538
39MP0005248_abnormal_Harderian_gland1.80739140
40MP0004782_abnormal_surfactant_physiolog1.80056893
41MP0002233_abnormal_nose_morphology1.78612818
42MP0000049_abnormal_middle_ear1.78582250
43MP0005646_abnormal_pituitary_gland1.77478929
44MP0002398_abnormal_bone_marrow1.77127668
45MP0001845_abnormal_inflammatory_respons1.75639861
46MP0003941_abnormal_skin_development1.73321938
47MP0009379_abnormal_foot_pigmentation1.72704983
48MP0002132_abnormal_respiratory_system1.66359222
49MP0002098_abnormal_vibrissa_morphology1.64691493
50MP0001533_abnormal_skeleton_physiology1.62547383
51MP0003787_abnormal_imprinting1.61795209
52MP0000689_abnormal_spleen_morphology1.59796363
53MP0003300_gastrointestinal_ulcer1.55787160
54MP0002249_abnormal_larynx_morphology1.54277847
55MP0005310_abnormal_salivary_gland1.52916939
56MP0003866_abnormal_defecation1.51851228
57MP0004947_skin_inflammation1.50885744
58MP0002396_abnormal_hematopoietic_system1.50563737
59MP0003786_premature_aging1.49595632
60MP0000467_abnormal_esophagus_morphology1.49433199
61MP0003806_abnormal_nucleotide_metabolis1.47903743
62MP0008469_abnormal_protein_level1.45623813
63MP0003656_abnormal_erythrocyte_physiolo1.44434984
64MP0002429_abnormal_blood_cell1.42859736
65MP0001188_hyperpigmentation1.41560293
66MP0002139_abnormal_hepatobiliary_system1.39915739
67MP0003183_abnormal_peptide_metabolism1.39594723
68MP0002722_abnormal_immune_system1.38265169
69MP0008004_abnormal_stomach_pH1.36380074
70MP0005058_abnormal_lysosome_morphology1.35173096
71MP0005409_darkened_coat_color1.32281315
72MP0001501_abnormal_sleep_pattern1.29927402
73MP0002138_abnormal_hepatobiliary_system1.29408211
74MP0003724_increased_susceptibility_to1.29387069
75MP0003195_calcinosis1.28478156
76MP0003075_altered_response_to1.27816314
77MP0004808_abnormal_hematopoietic_stem1.23151118
78MP0000372_irregular_coat_pigmentation1.21664745
79MP0001873_stomach_inflammation1.21047343
80MP0009250_abnormal_appendicular_skeleto1.20471542
81MP0005075_abnormal_melanosome_morpholog1.20397770
82MP0000569_abnormal_digit_pigmentation1.20348088
83MP0000383_abnormal_hair_follicle1.20162783
84MP0005377_hearing/vestibular/ear_phenot1.19120469
85MP0003878_abnormal_ear_physiology1.19120469
86MP0001270_distended_abdomen1.18612934
87MP0002060_abnormal_skin_morphology1.14644877
88MP0002998_abnormal_bone_remodeling1.12741829
89MP0004134_abnormal_chest_morphology1.12583034
90MP0000681_abnormal_thyroid_gland1.10127763
91MP0002876_abnormal_thyroid_physiology1.09377452
92MP0000604_amyloidosis1.09361065
93MP0001986_abnormal_taste_sensitivity1.08901244
94MP0009764_decreased_sensitivity_to1.06240145
95MP0002234_abnormal_pharynx_morphology1.05667684
96MP0000534_abnormal_ureter_morphology1.05533014
97MP0008995_early_reproductive_senescence1.04088531
98MP0009333_abnormal_splenocyte_physiolog1.03793261
99MP0010368_abnormal_lymphatic_system1.03041165
100MP0009785_altered_susceptibility_to1.02592519
101MP0009840_abnormal_foam_cell1.01136595
102MP0003136_yellow_coat_color0.99058706
103MP0001905_abnormal_dopamine_level0.98934037
104MP0002938_white_spotting0.97178053
105MP0001851_eye_inflammation0.94931689
106MP0003937_abnormal_limbs/digits/tail_de0.94400109
107MP0004381_abnormal_hair_follicle0.94308905
108MP0001835_abnormal_antigen_presentation0.94188922
109MP0000343_altered_response_to0.94135227
110MP0004043_abnormal_pH_regulation0.93066679
111MP0000703_abnormal_thymus_morphology0.93036639
112MP0005164_abnormal_response_to0.92447505
113MP0000538_abnormal_urinary_bladder0.92083093
114MP0000647_abnormal_sebaceous_gland0.91892283
115MP0003755_abnormal_palate_morphology0.90708256
116MP0002177_abnormal_outer_ear0.90415775
117MP0003828_pulmonary_edema0.89390329
118MP0005174_abnormal_tail_pigmentation0.88249470
119MP0000015_abnormal_ear_pigmentation0.87876540
120MP0010678_abnormal_skin_adnexa0.86992411
121MP0001663_abnormal_digestive_system0.86978672
122MP0002009_preneoplasia0.86265834
123MP0005171_absent_coat_pigmentation0.86231673
124MP0009763_increased_sensitivity_to0.85615270
125MP0003690_abnormal_glial_cell0.83609541
126MP0003252_abnormal_bile_duct0.83567726
127MP0009765_abnormal_xenobiotic_induced0.83076698
128MP0001186_pigmentation_phenotype0.82880124
129MP0004147_increased_porphyrin_level0.82554449
130MP0000249_abnormal_blood_vessel0.81924487
131MP0000627_abnormal_mammary_gland0.79984995
132MP0008872_abnormal_physiological_respon0.79611850
133MP0001216_abnormal_epidermal_layer0.79440286
134MP0000579_abnormal_nail_morphology0.78489407
135MP0005165_increased_susceptibility_to0.78311191
136MP0005408_hypopigmentation0.77530823
137MP0009053_abnormal_anal_canal0.76917292
138MP0004883_abnormal_blood_vessel0.76868816
139MP0002751_abnormal_autonomic_nervous0.76475688
140MP0003566_abnormal_cell_adhesion0.76448924
141MP0005166_decreased_susceptibility_to0.74939401
142MP0008007_abnormal_cellular_replicative0.72532034
143MP0003890_abnormal_embryonic-extraembry0.70687399
144MP0010155_abnormal_intestine_physiology0.70576548
145MP0001177_atelectasis0.70293396
146MP0002933_joint_inflammation0.70282725
147MP0001790_abnormal_immune_system0.68469018
148MP0005387_immune_system_phenotype0.68469018
149MP0002095_abnormal_skin_pigmentation0.67968841
150MP0002166_altered_tumor_susceptibility0.67460728
151MP0000858_altered_metastatic_potential0.67343942
152MP0002136_abnormal_kidney_physiology0.67217557
153MP0003448_altered_tumor_morphology0.67177695
154MP0005508_abnormal_skeleton_morphology0.67028177
155MP0005390_skeleton_phenotype0.67004646
156MP0005167_abnormal_blood-brain_barrier0.66764082
157MP0006082_CNS_inflammation0.66189410
158MP0000163_abnormal_cartilage_morphology0.65820105
159MP0002419_abnormal_innate_immunity0.64844969
160MP0000537_abnormal_urethra_morphology0.63603311
161MP0005645_abnormal_hypothalamus_physiol0.62508505
162MP0001764_abnormal_homeostasis0.61932866
163MP0002116_abnormal_craniofacial_bone0.61746945
164MP0002405_respiratory_system_inflammati0.61576123
165MP0003045_fibrosis0.61379966
166MP0001853_heart_inflammation0.61072318
167MP0003453_abnormal_keratinocyte_physiol0.60566210
168MP0008260_abnormal_autophagy0.60400290
169MP0002133_abnormal_respiratory_system0.59365515
170MP0001765_abnormal_ion_homeostasis0.57468002
171MP0002332_abnormal_exercise_endurance0.54766247
172MP0000371_diluted_coat_color0.54593540
173MP0002019_abnormal_tumor_incidence0.54407245
174MP0001664_abnormal_digestion0.53407388
175MP0009643_abnormal_urine_homeostasis0.51527216

Predicted human phenotypes

RankGene SetZ-score
1Urethral obstruction (HP:0000796)5.76276344
2Stomach cancer (HP:0012126)5.69430904
3Lip pit (HP:0100267)4.84942412
4Myositis (HP:0100614)4.46329834
5Agammaglobulinemia (HP:0004432)4.38342213
6Onycholysis (HP:0001806)4.18058290
7Recurrent bacterial skin infections (HP:0005406)4.03005004
8Recurrent abscess formation (HP:0002722)3.95734964
9Vasculitis (HP:0002633)3.74429642
10Meningitis (HP:0001287)3.74337937
11Elevated erythrocyte sedimentation rate (HP:0003565)3.69203319
12Distal lower limb muscle weakness (HP:0009053)3.61616242
13Stomatitis (HP:0010280)3.59969135
14Neoplasm of the adrenal cortex (HP:0100641)3.54556784
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.48432603
16Colitis (HP:0002583)3.48230382
17Pulmonary infiltrates (HP:0002113)3.47479550
18Alveolar cell carcinoma (HP:0006519)3.39852182
19Prostate neoplasm (HP:0100787)3.38700182
20Panhypogammaglobulinemia (HP:0003139)3.37966644
21Abnormality of glycolipid metabolism (HP:0010969)3.29231976
22Abnormality of liposaccharide metabolism (HP:0010968)3.29231976
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.29231976
24Milia (HP:0001056)3.27020601
25Gastrointestinal stroma tumor (HP:0100723)3.26370924
26Recurrent sinusitis (HP:0011108)3.26078322
27Recurrent fungal infections (HP:0002841)3.24036421
28Increased cerebral lipofuscin (HP:0011813)3.19874003
29Inflammation of the large intestine (HP:0002037)3.15517749
30Right ventricular cardiomyopathy (HP:0011663)3.11502452
31Encephalitis (HP:0002383)3.09888102
32Chronic obstructive pulmonary disease (HP:0006510)3.02935558
33Obstructive lung disease (HP:0006536)3.02935558
34Hemoptysis (HP:0002105)3.02302593
35Neoplasm of the tracheobronchial system (HP:0100552)3.01650915
36Recurrent viral infections (HP:0004429)2.99937651
37Chronic mucocutaneous candidiasis (HP:0002728)2.98618599
38Recurrent cutaneous fungal infections (HP:0011370)2.98618599
39Hydroureter (HP:0000072)2.98410692
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.97983917
41Abnormality of T cell number (HP:0011839)2.96597927
42Gastrointestinal inflammation (HP:0004386)2.93143494
43T lymphocytopenia (HP:0005403)2.92762260
44Abnormality of the vasculature of the conjunctiva (HP:0008054)2.91435883
45Flat acetabular roof (HP:0003180)2.90375497
46Arterial thrombosis (HP:0004420)2.88661515
47Abnormality of macrophages (HP:0004311)2.88576310
48Recurrent skin infections (HP:0001581)2.87873878
49Autoimmune thrombocytopenia (HP:0001973)2.87821467
50Systemic lupus erythematosus (HP:0002725)2.87727761
51Glomerulonephritis (HP:0000099)2.85827356
52Keratoconjunctivitis sicca (HP:0001097)2.84761396
53Bifid scrotum (HP:0000048)2.82189856
54Cheilitis (HP:0100825)2.75795258
55Gastrointestinal infarctions (HP:0005244)2.74502793
56Plantar hyperkeratosis (HP:0007556)2.74385267
57Abnormality of the renal collecting system (HP:0004742)2.73747710
58Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.73675567
59Recurrent bronchitis (HP:0002837)2.70490693
60Chest pain (HP:0100749)2.69802920
61Abnormal tarsal ossification (HP:0008369)2.68982587
62Down-sloping shoulders (HP:0200021)2.68424549
63Keratoconjunctivitis (HP:0001096)2.68223123
64Eczematoid dermatitis (HP:0000976)2.60550181
65Synostosis involving the elbow (HP:0003938)2.59703557
66Humeroradial synostosis (HP:0003041)2.59703557
67Hematochezia (HP:0002573)2.59399953
68Abnormality of T cells (HP:0002843)2.58764144
69Abnormality of the distal phalanges of the toes (HP:0010182)2.56841676
70Spontaneous hematomas (HP:0007420)2.56175233
71Hepatoblastoma (HP:0002884)2.55695157
72Pulmonary embolism (HP:0002204)2.52901175
73Chronic otitis media (HP:0000389)2.52839078
74Fragile nails (HP:0001808)2.52335514
75Leukocytosis (HP:0001974)2.51488867
76Restrictive lung disease (HP:0002091)2.50877877
77Cellulitis (HP:0100658)2.50485523
78Vacuolated lymphocytes (HP:0001922)2.49461635
79Submucous cleft hard palate (HP:0000176)2.46846044
80Aplasia/Hypoplasia of the scapulae (HP:0006713)2.46250820
81Hypoplastic scapulae (HP:0000882)2.46250820
82Abnormality of the pleura (HP:0002103)2.44109829
83Recurrent gram-negative bacterial infections (HP:0005420)2.43951529
84Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.42874490
85Urticaria (HP:0001025)2.42732219
86Chronic diarrhea (HP:0002028)2.42211339
87Long foot (HP:0001833)2.41542268
88Atrophic scars (HP:0001075)2.41497977
89True hermaphroditism (HP:0010459)2.41113999
90Autoimmune hemolytic anemia (HP:0001890)2.38953911
91Aplasia involving bones of the upper limbs (HP:0009823)2.37372619
92Aplasia of the phalanges of the hand (HP:0009802)2.37372619
93Aplasia involving bones of the extremities (HP:0009825)2.37372619
94Abnormality of the fovea (HP:0000493)2.35438654
95Osteomyelitis (HP:0002754)2.33268686
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.33182957
97Absent/shortened dynein arms (HP:0200106)2.33182957
98Abnormality of eosinophils (HP:0001879)2.32592413
99Epistaxis (HP:0000421)2.32505284
100Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.31006596
101Abnormal foot bone ossification (HP:0010675)2.30058852
102Nasolacrimal duct obstruction (HP:0000579)2.29928424
103Optic neuritis (HP:0100653)2.29764756
104Retrobulbar optic neuritis (HP:0100654)2.29764756
105Granulocytopenia (HP:0001913)2.29003914
106Dysostosis multiplex (HP:0000943)2.28766512
107IgM deficiency (HP:0002850)2.28016389
108Abnormal glucose tolerance (HP:0001952)2.27666692
109Gangrene (HP:0100758)2.27170735
110Congenital, generalized hypertrichosis (HP:0004540)2.26974039
111Abnormal pancreas size (HP:0012094)2.22833789
112IgG deficiency (HP:0004315)2.22765101
113Eosinophilia (HP:0001880)2.21106723
114Pulmonary fibrosis (HP:0002206)2.21035019
115Abnormality of the phalanges of the 2nd finger (HP:0009541)2.20862864
116Abnormality of B cell number (HP:0010975)2.20278765
117Abnormality of T cell physiology (HP:0011840)2.19680000
118Hypoplasia of the fovea (HP:0007750)2.19289619
119Aplasia/Hypoplasia of the fovea (HP:0008060)2.19289619
120Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.19182231
121Stillbirth (HP:0003826)2.19153185
122Pustule (HP:0200039)2.18617057
123Abnormal ciliary motility (HP:0012262)2.16378234
124Bronchitis (HP:0012387)2.14272118
125Abnormality of the middle phalanges of the toes (HP:0010183)2.13061499
126Tubulointerstitial nephritis (HP:0001970)2.12953364
127Popliteal pterygium (HP:0009756)2.12207488
128Polyneuropathy (HP:0001271)2.11343542
129Abnormality of the phalanges of the 5th finger (HP:0004213)2.10702054
130Lymphopenia (HP:0001888)2.10195027
131Cupped ear (HP:0000378)2.09049387
132Papilloma (HP:0012740)2.08898716
133Verrucae (HP:0200043)2.08898716
134Abnormality of male internal genitalia (HP:0000022)2.08570088
135Fibular aplasia (HP:0002990)2.07559637
136Median cleft lip (HP:0000161)2.07409835
137Long clavicles (HP:0000890)2.06425572
138Abnormal respiratory epithelium morphology (HP:0012253)2.05377201
139Abnormal respiratory motile cilium morphology (HP:0005938)2.05377201
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04684753
141Renal cortical cysts (HP:0000803)2.04503350
142Upper limb muscle weakness (HP:0003484)2.04234091
143Thrombocytosis (HP:0001894)2.02887256
144Orchitis (HP:0100796)2.02825248
145Vertigo (HP:0002321)2.02440994
146Acute hepatic failure (HP:0006554)2.01709037
147Skin rash (HP:0000988)2.01592789
148Abnormality of cells of the lymphoid lineage (HP:0012140)2.01227545
149Metaphyseal irregularity (HP:0003025)2.00636766
150Prolonged bleeding time (HP:0003010)2.00531535
151Absent eyebrow (HP:0002223)1.99039301
152Abnormality of polysaccharide metabolism (HP:0011012)1.98928289
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98928289
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98928289
155Congenital sensorineural hearing impairment (HP:0008527)1.98113965
156Abnormality of the lacrimal duct (HP:0011481)1.97606442
157Recurrent pneumonia (HP:0006532)1.97406183
158Abnormality of cochlea (HP:0000375)1.95852267
159Abnormality of incisor morphology (HP:0011063)1.93479998
160Hypoplasia of dental enamel (HP:0006297)1.93053564
161Periauricular skin pits (HP:0100277)1.92040718
162Preauricular pit (HP:0004467)1.92040718
163Advanced eruption of teeth (HP:0006288)1.90348049
164Male pseudohermaphroditism (HP:0000037)1.88500998
165Palmar hyperkeratosis (HP:0010765)1.87629031
166Neonatal hypoglycemia (HP:0001998)1.87526497
167Abnormal blistering of the skin (HP:0008066)1.84495817
168Abnormality of the prostate (HP:0008775)1.83420374
169Sparse scalp hair (HP:0002209)1.83206365
170Abnormal sex determination (HP:0012244)1.82942615
171Sex reversal (HP:0012245)1.82942615
172Abnormality of the nasal septum (HP:0000419)1.82009043
173Abnormality of the nasolacrimal system (HP:0000614)1.81107854
174Natal tooth (HP:0000695)1.80086669
175Mediastinal lymphadenopathy (HP:0100721)1.79019517
176Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78808617
177Short nail (HP:0001799)1.77373641
178White forelock (HP:0002211)1.77302849
179Morphological abnormality of the middle ear (HP:0008609)1.77275424
180Abnormality of carpal bone ossification (HP:0006257)1.76836824
181Alopecia of scalp (HP:0002293)1.75175268
182Germ cell neoplasia (HP:0100728)1.75101724
183Thick nail (HP:0001805)1.74954252
184Chromsome breakage (HP:0040012)1.74890530
185Tarsal synostosis (HP:0008368)1.74301564
186Ridged nail (HP:0001807)1.73943453
187Stenosis of the external auditory canal (HP:0000402)1.73841291
188Chronic sinusitis (HP:0011109)1.71023351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.67070696
2ZAK4.55658235
3ERBB34.37512909
4MAP4K13.41477589
5TAOK33.32397877
6RIPK43.25630067
7TRPM73.03399246
8FRK2.95831886
9KIT2.89138577
10IRAK32.70831402
11CSF1R2.57257750
12IRAK42.48900924
13BLK2.40182156
14FES2.35118041
15NUAK12.31529495
16EPHB22.26367859
17MAP3K142.21169102
18SYK2.19651265
19MAP3K32.18167018
20ERN12.12302276
21TBK12.05092037
22MAP3K131.97890118
23MATK1.90179567
24MAPK151.88664304
25STK38L1.86292546
26PIK3CG1.78222501
27SIK31.72146927
28BMPR21.71141364
29MAP3K121.68626843
30MKNK21.63268072
31INSRR1.62339686
32MST41.61765700
33TESK21.60172842
34SGK21.58140901
35NEK61.52693253
36ITK1.52079283
37NLK1.51785307
38HIPK21.50334530
39CASK1.48001940
40LYN1.47406973
41PBK1.47213493
42MAP3K21.45667157
43HCK1.45242167
44RIPK11.40575810
45EIF2AK31.39959413
46ZAP701.39421919
47GRK71.39330311
48BMPR1B1.39044081
49CSK1.38377959
50TNK21.37050963
51GRK61.34223410
52TGFBR21.33767195
53LCK1.26696788
54AKT31.20736193
55MAP2K21.18576310
56PRKG21.16985273
57MARK31.14320836
58TXK1.14233770
59FLT31.12055678
60TLK11.03642139
61IRAK11.02673441
62CDK81.00102880
63EPHA30.99110953
64STK160.97308235
65JAK20.95595614
66SGK2230.94425879
67SGK4940.94425879
68SIK20.94026978
69CDK190.93212514
70PRKCQ0.91579320
71SGK30.90920205
72MST1R0.90807946
73IKBKE0.89245308
74ACVR1B0.88047899
75MKNK10.87240767
76RPS6KB20.87156757
77PINK10.86920121
78ADRBK20.84370473
79MAPKAPK50.83268080
80PRPF4B0.81378769
81TAOK20.81004175
82CHUK0.80150524
83ERBB40.78353825
84FER0.75780565
85TEC0.74986541
86MYLK0.72968611
87IKBKB0.72812390
88TNIK0.72148122
89TESK10.71599098
90BCKDK0.71573512
91JAK30.70975001
92TYK20.68109924
93FGR0.67493504
94IRAK20.67203524
95BTK0.66934467
96ERBB20.66563368
97CDC42BPA0.65861326
98FGFR30.65311224
99MAP4K20.63711780
100GRK10.62019381
101MAPK70.60230961
102RPS6KA20.60005069
103PIM10.57819579
104MAP2K70.57669614
105RPS6KL10.57307382
106RPS6KC10.57307382
107KDR0.56615566
108PRKCE0.54470585
109IGF1R0.54405083
110MAP3K70.54038486
111RPS6KA60.53923356
112MAPK110.53707236
113MAP2K10.53459797
114PDK10.53153822
115PIK3CA0.52454659
116MAP3K10.51490502
117EIF2AK20.51400400
118CDK30.51065575
119OXSR10.49127155
120STK240.47987178
121EGFR0.47490736
122PRKD20.47441257
123YES10.47213595
124FYN0.46726561
125CSNK1A1L0.46373849
126PDK20.45736404
127MAP2K30.45124692
128DAPK20.45070294
129MARK20.43441740
130MAPKAPK30.43186491
131CAMK2B0.43083558
132TTK0.41884215
133STK100.41835124
134NME20.41523507
135PRKCI0.41310846
136ABL10.40442857
137CDK60.39825140
138MAP2K60.39816243
139MAPKAPK20.39775871
140CAMKK20.39182987
141ATR0.38741782
142CLK10.38288270
143CAMK2G0.38183244
144PIM20.38010238
145RPS6KA40.35883201
146NEK90.35568146
147MAPK120.33923898
148INSR0.33815557
149EPHB10.32915989
150MAPK30.31266281
151PRKCD0.31265472
152CAMK2D0.30916200
153JAK10.30491106
154BRD40.27716099
155CSNK1A10.27608944
156STK110.27591182
157CSNK1G10.27004932

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.94213478
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.69300381
3Asthma_Homo sapiens_hsa053104.48114766
4Chemical carcinogenesis_Homo sapiens_hsa052044.13833950
5Glutathione metabolism_Homo sapiens_hsa004803.81824107
6Staphylococcus aureus infection_Homo sapiens_hsa051503.42028256
7Type I diabetes mellitus_Homo sapiens_hsa049403.20230073
8Pentose and glucuronate interconversions_Homo sapiens_hsa000403.16961629
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.83695335
10Antigen processing and presentation_Homo sapiens_hsa046122.47844388
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.27353746
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20782660
13Graft-versus-host disease_Homo sapiens_hsa053322.20410813
14Primary immunodeficiency_Homo sapiens_hsa053402.12783770
15African trypanosomiasis_Homo sapiens_hsa051432.07318615
16B cell receptor signaling pathway_Homo sapiens_hsa046621.93837454
17Viral myocarditis_Homo sapiens_hsa054161.87308706
18Arachidonic acid metabolism_Homo sapiens_hsa005901.84084851
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.74991679
20Sulfur metabolism_Homo sapiens_hsa009201.68337968
21Rheumatoid arthritis_Homo sapiens_hsa053231.65927292
22Retinol metabolism_Homo sapiens_hsa008301.62090152
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.52708062
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50512473
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49680725
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35437102
27TNF signaling pathway_Homo sapiens_hsa046681.32206022
28Lysosome_Homo sapiens_hsa041421.31393196
29Pertussis_Homo sapiens_hsa051331.29503878
30Starch and sucrose metabolism_Homo sapiens_hsa005001.22632078
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19187761
32Circadian rhythm_Homo sapiens_hsa047101.17399486
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.11083197
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10480903
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10053099
36Malaria_Homo sapiens_hsa051441.08439552
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07836687
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04195876
39ABC transporters_Homo sapiens_hsa020101.03063237
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99468853
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.98620663
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94526245
43Legionellosis_Homo sapiens_hsa051340.94282709
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93253472
45Leishmaniasis_Homo sapiens_hsa051400.92384226
46Measles_Homo sapiens_hsa051620.91948373
47Adherens junction_Homo sapiens_hsa045200.91871137
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91542740
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88784745
50Influenza A_Homo sapiens_hsa051640.88312212
51Hematopoietic cell lineage_Homo sapiens_hsa046400.87230361
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86449093
53beta-Alanine metabolism_Homo sapiens_hsa004100.84546017
54Platelet activation_Homo sapiens_hsa046110.84150947
55T cell receptor signaling pathway_Homo sapiens_hsa046600.83908446
56Acute myeloid leukemia_Homo sapiens_hsa052210.82857156
57Phenylalanine metabolism_Homo sapiens_hsa003600.78893233
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78032318
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77454930
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76074241
61Systemic lupus erythematosus_Homo sapiens_hsa053220.75181908
62Histidine metabolism_Homo sapiens_hsa003400.74156863
63Toxoplasmosis_Homo sapiens_hsa051450.73688347
64Herpes simplex infection_Homo sapiens_hsa051680.72835373
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69150689
66Protein export_Homo sapiens_hsa030600.69001660
67Hepatitis C_Homo sapiens_hsa051600.68511064
68Phagosome_Homo sapiens_hsa041450.67162596
69Autoimmune thyroid disease_Homo sapiens_hsa053200.66678646
70Linoleic acid metabolism_Homo sapiens_hsa005910.64851191
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64507280
72Tuberculosis_Homo sapiens_hsa051520.64420883
73Mineral absorption_Homo sapiens_hsa049780.63595247
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62427950
75Prostate cancer_Homo sapiens_hsa052150.61426925
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60747042
77Vibrio cholerae infection_Homo sapiens_hsa051100.60022440
78Amoebiasis_Homo sapiens_hsa051460.59659612
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59587816
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.57865748
81ECM-receptor interaction_Homo sapiens_hsa045120.56981339
82Salmonella infection_Homo sapiens_hsa051320.56353445
83Hippo signaling pathway_Homo sapiens_hsa043900.55931241
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55399526
85Thyroid hormone synthesis_Homo sapiens_hsa049180.53321679
86Ether lipid metabolism_Homo sapiens_hsa005650.53160204
87Epstein-Barr virus infection_Homo sapiens_hsa051690.51895366
88RNA degradation_Homo sapiens_hsa030180.51270026
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50477592
90Allograft rejection_Homo sapiens_hsa053300.50338529
91Other glycan degradation_Homo sapiens_hsa005110.48530613
92Basal cell carcinoma_Homo sapiens_hsa052170.45768256
93Notch signaling pathway_Homo sapiens_hsa043300.44024314
94N-Glycan biosynthesis_Homo sapiens_hsa005100.43786776
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.43531986
96Galactose metabolism_Homo sapiens_hsa000520.42497889
97Tryptophan metabolism_Homo sapiens_hsa003800.42437175
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40807018
99Hepatitis B_Homo sapiens_hsa051610.40760424
100Endometrial cancer_Homo sapiens_hsa052130.40229777
101Osteoclast differentiation_Homo sapiens_hsa043800.39611616
102Olfactory transduction_Homo sapiens_hsa047400.39610959
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39346140
104Apoptosis_Homo sapiens_hsa042100.38328292
105Collecting duct acid secretion_Homo sapiens_hsa049660.37850890
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37504114
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34795938
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34782940
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34761314
110Prolactin signaling pathway_Homo sapiens_hsa049170.34618017
111Dorso-ventral axis formation_Homo sapiens_hsa043200.34583581
112Pathways in cancer_Homo sapiens_hsa052000.34146805
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.32233052
114Phototransduction_Homo sapiens_hsa047440.31696558
115Salivary secretion_Homo sapiens_hsa049700.31162330
116Chemokine signaling pathway_Homo sapiens_hsa040620.30754836
117TGF-beta signaling pathway_Homo sapiens_hsa043500.30556414
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30252407
119HTLV-I infection_Homo sapiens_hsa051660.30199927
120Sphingolipid metabolism_Homo sapiens_hsa006000.30061418
121Tight junction_Homo sapiens_hsa045300.29426531
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29399180
123FoxO signaling pathway_Homo sapiens_hsa040680.28929061
124Prion diseases_Homo sapiens_hsa050200.27903024
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.27574498
126Thyroid cancer_Homo sapiens_hsa052160.27115266
127Renin secretion_Homo sapiens_hsa049240.26814842
128Vitamin digestion and absorption_Homo sapiens_hsa049770.24630077
129Caffeine metabolism_Homo sapiens_hsa002320.24098934
130Gastric acid secretion_Homo sapiens_hsa049710.23750390
131Glycerolipid metabolism_Homo sapiens_hsa005610.23085878
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22954909
133Complement and coagulation cascades_Homo sapiens_hsa046100.22724356
134Small cell lung cancer_Homo sapiens_hsa052220.22294861
135Inositol phosphate metabolism_Homo sapiens_hsa005620.20894760
136Non-small cell lung cancer_Homo sapiens_hsa052230.20303133
137Regulation of autophagy_Homo sapiens_hsa041400.19023262
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.17563652
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.16954382
140Pancreatic cancer_Homo sapiens_hsa052120.16300984
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.13789444
142Insulin resistance_Homo sapiens_hsa049310.13468838
143Renin-angiotensin system_Homo sapiens_hsa046140.12843451
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.12785282
145Shigellosis_Homo sapiens_hsa051310.11803679

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