ADAM30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varying numbers of C-terminal repeats. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.74191328
2cell wall macromolecule metabolic process (GO:0044036)9.74191328
3acrosome assembly (GO:0001675)9.49392380
4* sperm-egg recognition (GO:0035036)9.47674678
5axonemal dynein complex assembly (GO:0070286)9.37161145
6acrosome reaction (GO:0007340)9.20836611
7plasma membrane fusion (GO:0045026)9.20162267
8epithelial cilium movement (GO:0003351)8.60923711
9motile cilium assembly (GO:0044458)8.52600351
10* reproduction (GO:0000003)8.51188341
11* cell-cell recognition (GO:0009988)8.44263453
12piRNA metabolic process (GO:0034587)8.41499477
13* binding of sperm to zona pellucida (GO:0007339)8.39153495
14spermatid development (GO:0007286)7.92788993
15male meiosis (GO:0007140)7.33531068
16cilium movement (GO:0003341)7.32518788
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.04086835
18* single fertilization (GO:0007338)6.41756575
19synaptonemal complex organization (GO:0070193)6.39594488
20regulation of cilium movement (GO:0003352)6.12154033
21synaptonemal complex assembly (GO:0007130)6.06263737
22sperm capacitation (GO:0048240)5.78656531
23* fertilization (GO:0009566)5.52968256
24spermatogenesis (GO:0007283)5.13706776
25male gamete generation (GO:0048232)5.11434314
26DNA methylation involved in gamete generation (GO:0043046)4.99329431
27negative regulation of inclusion body assembly (GO:0090084)4.93844863
28organic cation transport (GO:0015695)4.89706511
29male meiosis I (GO:0007141)4.87499960
30gamete generation (GO:0007276)4.71522854
31ventricular system development (GO:0021591)4.65401658
32cellular process involved in reproduction in multicellular organism (GO:0022412)4.47702452
33germ cell development (GO:0007281)4.34724331
34chromosome organization involved in meiosis (GO:0070192)4.30672392
35microtubule depolymerization (GO:0007019)4.30331736
36cellular response to exogenous dsRNA (GO:0071360)4.25181492
37meiotic nuclear division (GO:0007126)4.11230201
38calcium ion-dependent exocytosis (GO:0017156)4.09434182
39* cell recognition (GO:0008037)3.91005619
40regulation of inclusion body assembly (GO:0090083)3.86423219
41seminiferous tubule development (GO:0072520)3.86167466
42meiotic cell cycle (GO:0051321)3.82112171
43meiosis I (GO:0007127)3.72179112
44multicellular organismal reproductive process (GO:0048609)3.68839615
45spermatid nucleus differentiation (GO:0007289)3.51656141
46monoubiquitinated protein deubiquitination (GO:0035520)3.38554931
47sexual reproduction (GO:0019953)3.32254226
48regulation of microtubule-based movement (GO:0060632)3.27353504
49microtubule severing (GO:0051013)3.23120727
50response to peptidoglycan (GO:0032494)3.20218223
51protein K11-linked deubiquitination (GO:0035871)3.19773702
52regulation of podosome assembly (GO:0071801)3.19678861
53regulation of activation of Janus kinase activity (GO:0010533)3.18586957
54positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.16908608
55protein localization to cilium (GO:0061512)3.15409216
56left/right pattern formation (GO:0060972)3.13077947
57genitalia morphogenesis (GO:0035112)3.04870469
58glycerol ether metabolic process (GO:0006662)2.98152861
59eosinophil chemotaxis (GO:0048245)2.97591918
60multicellular organismal development (GO:0007275)2.95915458
61lactate metabolic process (GO:0006089)2.95261253
62negative regulation of viral genome replication (GO:0045071)2.90390482
63regulation of T-helper 1 cell differentiation (GO:0045625)2.86594247
64natural killer cell mediated immunity (GO:0002228)2.85813595
65natural killer cell mediated cytotoxicity (GO:0042267)2.85813595
66nucleoside diphosphate phosphorylation (GO:0006165)2.82917346
67regulation of centriole replication (GO:0046599)2.81700283
68positive regulation of mast cell degranulation (GO:0043306)2.78657272
69positive regulation of mast cell activation involved in immune response (GO:0033008)2.78657272
70regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.76629214
71synapsis (GO:0007129)2.74672771
72regulation of mononuclear cell migration (GO:0071675)2.74229311
73centriole assembly (GO:0098534)2.73869064
74ether metabolic process (GO:0018904)2.72446166
75centriole replication (GO:0007099)2.70477506
76gene silencing by RNA (GO:0031047)2.69656441
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.63519177
78regulation of protein polyubiquitination (GO:1902914)2.59803457
79eosinophil migration (GO:0072677)2.57874814
80single strand break repair (GO:0000012)2.54338122
81polyol catabolic process (GO:0046174)2.53499219
82sequestering of actin monomers (GO:0042989)2.52980134
83chromosome condensation (GO:0030261)2.52789157
84positive regulation of monocyte chemotaxis (GO:0090026)2.51891707
85alditol metabolic process (GO:0019400)2.50984233
86regulation of chronic inflammatory response (GO:0002676)2.50388275
87cellular response to heat (GO:0034605)2.49461719
88positive regulation of chemokine biosynthetic process (GO:0045080)2.48418560
89protein refolding (GO:0042026)2.46597827
90microtubule-based movement (GO:0007018)2.45967161
91monocyte chemotaxis (GO:0002548)2.44135022
92chaperone-mediated protein complex assembly (GO:0051131)2.44085322
93cilium organization (GO:0044782)2.41119792
94regulation of RIG-I signaling pathway (GO:0039535)2.41072402
95positive regulation of lymphocyte migration (GO:2000403)2.40681093
96DNA packaging (GO:0006323)2.40473607
97fusion of sperm to egg plasma membrane (GO:0007342)12.2433255
98cilium or flagellum-dependent cell motility (GO:0001539)12.1103080
99sperm motility (GO:0030317)11.0997630
100* multicellular organism reproduction (GO:0032504)10.0686857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.40800046
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.17620066
3EZH2_22144423_ChIP-Seq_EOC_Human3.60134861
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.56450443
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.27160152
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.19890881
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.08392109
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.43533027
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29085717
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21635615
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17973490
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04082092
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.03078973
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96638483
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88495899
16STAT1_17558387_ChIP-Seq_HELA_Human1.86283430
17NFE2_27457419_Chip-Seq_LIVER_Mouse1.79320893
18KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77845395
19SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63393459
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57359214
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55392756
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53896260
23PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53381753
24TAL1_26923725_Chip-Seq_HPCs_Mouse1.47690017
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.47177721
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.41765982
27KDM2B_26808549_Chip-Seq_REH_Human1.41313535
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40584284
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39166675
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.38914878
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37807357
32CRX_20693478_ChIP-Seq_RETINA_Mouse1.37757916
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.36689892
34VDR_22108803_ChIP-Seq_LS180_Human1.36572300
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.36416634
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.36192312
37P53_22387025_ChIP-Seq_ESCs_Mouse1.34392316
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33789645
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33680795
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32732619
41FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31551222
42ZNF274_21170338_ChIP-Seq_K562_Hela1.31506869
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30300786
44* OCT4_18555785_Chip-Seq_ESCs_Mouse1.29338729
45P300_18555785_Chip-Seq_ESCs_Mouse1.28883845
46PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28866130
47CMYC_18555785_Chip-Seq_ESCs_Mouse1.28087328
48EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27981056
49OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26355986
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24783182
51PU1_27457419_Chip-Seq_LIVER_Mouse1.23277075
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22869663
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.22001157
54* STAT3_18555785_Chip-Seq_ESCs_Mouse1.19833103
55ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19818550
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19504086
57GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.18169996
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17629404
59GATA3_21867929_ChIP-Seq_TH1_Mouse1.17173905
60VDR_24787735_ChIP-Seq_THP-1_Human1.16302043
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16268262
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15482112
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15210231
64KLF4_18555785_Chip-Seq_ESCs_Mouse1.14589330
65SOX2_22085726_ChIP-Seq_NPCs_Mouse1.13159096
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12518163
67CBP_20019798_ChIP-Seq_JUKART_Human1.12518163
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10624943
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09953435
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.09307641
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.09299035
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05135224
73GF1_26923725_Chip-Seq_HPCs_Mouse1.04294790
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.04131942
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.04080377
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02939272
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.02917364
78GATA3_21867929_ChIP-Seq_CD8_Mouse1.01565604
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00854345
80ZFX_18555785_Chip-Seq_ESCs_Mouse0.99480190
81NMYC_18555785_Chip-Seq_ESCs_Mouse0.99307363
82CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99206757
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99072208
84* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99053876
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98474908
86* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97898015
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96771315
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96607742
89* WDR5_24793694_ChIP-Seq_LNCAP_Human0.94155626
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93576570
91MYC_27129775_Chip-Seq_CORNEA_Mouse0.92780196
92RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91891636
93CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90880475
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90498869
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90390917
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90159193
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90075695
98SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89121392
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89006345
100MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88983861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.67837374
2MP0001929_abnormal_gametogenesis4.24425167
3MP0006082_CNS_inflammation3.78486681
4MP0008877_abnormal_DNA_methylation3.21115172
5MP0003436_decreased_susceptibility_to3.17922196
6MP0002210_abnormal_sex_determination2.96465111
7MP0001835_abnormal_antigen_presentation2.82887887
8MP0009785_altered_susceptibility_to2.78805665
9MP0002148_abnormal_hypersensitivity_rea2.72523119
10MP0002161_abnormal_fertility/fecundity2.45188257
11MP0005623_abnormal_meninges_morphology2.41090551
12MP0001145_abnormal_male_reproductive2.32044521
13MP0005000_abnormal_immune_tolerance2.09731553
14MP0000653_abnormal_sex_gland2.00490513
15MP0005410_abnormal_fertilization12.8609934
16MP0005025_abnormal_response_to1.97770035
17MP0002653_abnormal_ependyma_morphology1.91111187
18MP0003724_increased_susceptibility_to1.89349148
19MP0002419_abnormal_innate_immunity1.84236125
20MP0003303_peritoneal_inflammation1.81088528
21MP0009278_abnormal_bone_marrow1.69169346
22MP0003646_muscle_fatigue1.62757697
23MP0009764_decreased_sensitivity_to1.59382917
24MP0001533_abnormal_skeleton_physiology1.44411734
25MP0008004_abnormal_stomach_pH1.41501759
26MP0002723_abnormal_immune_serum1.35122583
27MP0003011_delayed_dark_adaptation1.30102915
28MP0002452_abnormal_antigen_presenting1.28688956
29MP0005387_immune_system_phenotype1.17321977
30MP0001790_abnormal_immune_system1.17321977
31MP0008469_abnormal_protein_level1.16997697
32MP0003690_abnormal_glial_cell1.14151315
33MP0008057_abnormal_DNA_replication1.14014283
34MP0005671_abnormal_response_to1.12770581
35MP0001545_abnormal_hematopoietic_system1.12002497
36MP0005397_hematopoietic_system_phenotyp1.12002497
37MP0002405_respiratory_system_inflammati1.10974928
38MP0002282_abnormal_trachea_morphology1.10598533
39MP0002736_abnormal_nociception_after1.07398773
40MP0005670_abnormal_white_adipose1.07071650
41MP0001800_abnormal_humoral_immune1.02524803
42MP0001845_abnormal_inflammatory_respons1.02408173
43MP0001819_abnormal_immune_cell0.99078331
44MP0002420_abnormal_adaptive_immunity0.96692203
45MP0000343_altered_response_to0.96166782
46MP0003950_abnormal_plasma_membrane0.94124749
47MP0004510_myositis0.92692887
48MP0000685_abnormal_immune_system0.92250231
49MP0005647_abnormal_sex_gland0.90289526
50MP0004947_skin_inflammation0.88509116
51MP0002160_abnormal_reproductive_system0.85986310
52MP0001765_abnormal_ion_homeostasis0.84695103
53MP0003448_altered_tumor_morphology0.84496465
54MP0009046_muscle_twitch0.83132247
55MP0000604_amyloidosis0.79227168
56MP0010386_abnormal_urinary_bladder0.79020578
57MP0005535_abnormal_body_temperature0.78370804
58MP0002006_tumorigenesis0.72077336
59MP0009763_increased_sensitivity_to0.71896415
60MP0010155_abnormal_intestine_physiology0.70647201
61MP0002998_abnormal_bone_remodeling0.70436857
62MP0005464_abnormal_platelet_physiology0.68197132
63MP0000716_abnormal_immune_system0.64841179
64MP0001968_abnormal_touch/_nociception0.64508712
65MP0010307_abnormal_tumor_latency0.64500394
66MP0004808_abnormal_hematopoietic_stem0.62725786
67MP0005390_skeleton_phenotype0.61225781
68MP0009115_abnormal_fat_cell0.61124581
69MP0001851_eye_inflammation0.60426197
70MP0005166_decreased_susceptibility_to0.59974066
71MP0003045_fibrosis0.59500788
72MP0005164_abnormal_response_to0.59224699
73MP0003191_abnormal_cellular_cholesterol0.58224667
74MP0004782_abnormal_surfactant_physiolog0.58081672
75MP0000858_altered_metastatic_potential0.56157541
76MP0005167_abnormal_blood-brain_barrier0.56110167
77MP0003075_altered_response_to0.55678129
78MP0001119_abnormal_female_reproductive0.54290346
79MP0004019_abnormal_vitamin_homeostasis0.54215329
80MP0002928_abnormal_bile_duct0.52537966
81MP0002398_abnormal_bone_marrow0.51543467
82MP0002138_abnormal_hepatobiliary_system0.51469980
83MP0002693_abnormal_pancreas_physiology0.50687153
84MP0010352_gastrointestinal_tract_polyps0.49710541
85MP0005058_abnormal_lysosome_morphology0.49624328
86MP0001853_heart_inflammation0.48114589
87MP0005666_abnormal_adipose_tissue0.46396100
88MP0001663_abnormal_digestive_system0.44924366
89MP0005389_reproductive_system_phenotype0.44359480
90MP0002429_abnormal_blood_cell0.43982274
91MP0005636_abnormal_mineral_homeostasis0.40367408
92MP0005310_abnormal_salivary_gland0.39341870
93MP0005076_abnormal_cell_differentiation0.39194188
94MP0000249_abnormal_blood_vessel0.39165211
95MP0001764_abnormal_homeostasis0.38589102
96MP0003172_abnormal_lysosome_physiology0.38348303
97MP0005451_abnormal_body_composition0.37204317
98MP0009765_abnormal_xenobiotic_induced0.36568242
99MP0002971_abnormal_brown_adipose0.36366598
100MP0008058_abnormal_DNA_repair0.34542765

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.63928988
2Abnormal respiratory motile cilium morphology (HP:0005938)8.29448437
3Abnormal respiratory epithelium morphology (HP:0012253)8.29448437
4Rhinitis (HP:0012384)7.22087114
5Abnormal ciliary motility (HP:0012262)6.97544434
6Nasal polyposis (HP:0100582)6.87321693
7Chronic bronchitis (HP:0004469)6.57954917
8Abnormality of the nasal mucosa (HP:0000433)5.68155798
9Infertility (HP:0000789)5.64477346
10Bronchiectasis (HP:0002110)4.61050012
11Bronchitis (HP:0012387)4.48765536
12Nephronophthisis (HP:0000090)3.86767539
13Recurrent sinusitis (HP:0011108)3.55134531
14Recurrent otitis media (HP:0000403)3.16678939
15Recurrent bronchitis (HP:0002837)3.09305949
16Abnormality of the renal medulla (HP:0100957)3.06575211
17Male infertility (HP:0003251)3.01646009
18Tubular atrophy (HP:0000092)2.89726844
19Absent frontal sinuses (HP:0002688)2.77839370
20Tubulointerstitial nephritis (HP:0001970)2.67387412
21Dyschromatopsia (HP:0007641)2.67148063
22Tubulointerstitial abnormality (HP:0001969)2.64435310
23Abnormal spermatogenesis (HP:0008669)2.59930106
24Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.47037258
25Chronic sinusitis (HP:0011109)2.43814710
26Tubulointerstitial fibrosis (HP:0005576)2.39801278
27Molar tooth sign on MRI (HP:0002419)2.32451386
28Abnormality of midbrain morphology (HP:0002418)2.32451386
29Eczematoid dermatitis (HP:0000976)2.31000704
30Recurrent gram-negative bacterial infections (HP:0005420)2.26572341
31Spastic tetraparesis (HP:0001285)2.16490723
32Abnormality of the lower motor neuron (HP:0002366)2.10806034
33Azoospermia (HP:0000027)2.06936975
34Abnormality of the frontal sinuses (HP:0002687)2.05427147
35Gonadotropin excess (HP:0000837)2.04267820
36Upper motor neuron abnormality (HP:0002127)2.03289491
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3184005
38Absent/shortened dynein arms (HP:0200106)11.8837628
39Dynein arm defect of respiratory motile cilia (HP:0012255)11.8837628
40Medial flaring of the eyebrow (HP:0010747)1.99626238
41Optic neuritis (HP:0100653)1.98706622
42Retrobulbar optic neuritis (HP:0100654)1.98706622
43Deformed sella turcica (HP:0002681)1.96813033
44Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.91642354
45Abnormality of the renal cortex (HP:0011035)1.89022969
46Autoimmune thrombocytopenia (HP:0001973)1.88618700
47Stomatitis (HP:0010280)1.87127887
48Amyotrophic lateral sclerosis (HP:0007354)1.86135896
49Stage 5 chronic kidney disease (HP:0003774)1.85837608
50Recurrent abscess formation (HP:0002722)1.83414759
51Orchitis (HP:0100796)1.79067627
52J-shaped sella turcica (HP:0002680)1.77806455
53Impulsivity (HP:0100710)1.76072655
54Postaxial foot polydactyly (HP:0001830)1.73884035
55Chronic otitis media (HP:0000389)1.73831021
56Congenital hepatic fibrosis (HP:0002612)1.70495395
57Abnormality of the dental root (HP:0006486)1.70320879
58Taurodontia (HP:0000679)1.70320879
59Abnormality of permanent molar morphology (HP:0011071)1.70320879
60Fibular hypoplasia (HP:0003038)1.67748422
61Abnormal drinking behavior (HP:0030082)1.67145797
62Polydipsia (HP:0001959)1.67145797
63Abnormality of molar (HP:0011077)1.62790158
64Abnormality of molar morphology (HP:0011070)1.62790158
65Vascular calcification (HP:0004934)1.60504777
66Constricted visual fields (HP:0001133)1.57902780
67Hyperphosphatemia (HP:0002905)1.57438506
68Abnormality of dentin (HP:0010299)1.57231109
69Degeneration of anterior horn cells (HP:0002398)1.57187647
70Abnormality of the anterior horn cell (HP:0006802)1.57187647
71Recurrent bacterial skin infections (HP:0005406)1.55437673
72Impaired proprioception (HP:0010831)1.54996556
73Abnormality of the dental pulp (HP:0006479)1.54857702
74Oculomotor apraxia (HP:0000657)1.53675259
75Hemorrhage of the eye (HP:0011885)1.53641079
76Abnormality of renal excretion (HP:0011036)1.53426001
77Prostate neoplasm (HP:0100787)1.47585843
78Hypergammaglobulinemia (HP:0010702)1.46138613
79Cardiovascular calcification (HP:0011915)1.44125745
80Myositis (HP:0100614)1.41975516
81Interstitial pulmonary disease (HP:0006530)1.41971532
82Systemic lupus erythematosus (HP:0002725)1.41469508
83Disinhibition (HP:0000734)1.41046203
84Hemiparesis (HP:0001269)1.39485569
85Mediastinal lymphadenopathy (HP:0100721)1.39330455
86Nephropathy (HP:0000112)1.39198865
87Choroideremia (HP:0001139)1.38422696
88Renal dysplasia (HP:0000110)1.36184786
89Microglossia (HP:0000171)1.36084656
90Short thorax (HP:0010306)1.34081285
91Short ribs (HP:0000773)1.33265291
92Abnormality of the sella turcica (HP:0002679)1.32408208
93Short nail (HP:0001799)1.32162944
94Central scotoma (HP:0000603)1.30060788
95Gingivitis (HP:0000230)1.29405887
96Decreased central vision (HP:0007663)1.29190751
97Median cleft lip (HP:0000161)1.25480890
98Porencephaly (HP:0002132)1.25249001
99Short femoral neck (HP:0100864)1.24380551
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.24170645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.17423392
2PDK48.17423392
3PDK25.74171662
4TESK14.31757765
5PRKD33.10647682
6ICK2.59776851
7PBK2.15367055
8PTK2B2.14989167
9WNK42.10839402
10ERN12.06723417
11STK392.05473357
12EPHB11.78373745
13RIPK41.61849850
14MUSK1.56457790
15MAP3K141.56361290
16PNCK1.55206101
17IRAK11.50660604
18TBK11.34058674
19NEK21.20918120
20WNK11.16794248
21STK31.14977171
22EPHA31.09600936
23MAPK151.09197913
24TXK0.99767247
25STK380.93379902
26PDK10.92909969
27IKBKE0.92551916
28CDK120.89845246
29DYRK1B0.89351804
30TYK20.84940712
31CSK0.83241702
32BMPR1B0.80960338
33MST40.76882692
34PLK40.72908007
35MATK0.70751531
36BLK0.67827685
37IKBKB0.61903106
38ZAP700.60968865
39JAK30.60546665
40JAK10.54796150
41FGFR40.53929093
42BMPR20.49113486
43NEK90.48215165
44PRKCQ0.47850559
45IRAK20.44162291
46MAP4K10.43384172
47MAP2K60.42185216
48ADRBK20.39312662
49YES10.39026537
50MAP3K50.38075977
51PDPK10.37042373
52RIPK10.35972204
53PINK10.34563228
54TYRO30.33035645
55LMTK20.32930210
56ABL20.32526602
57NLK0.30325153
58PIM10.30027342
59CLK10.29814754
60EIF2AK20.29565363
61BMX0.29251842
62MAP3K130.27381147
63IRAK40.27362795
64GRK70.26990055
65STK40.26759545
66PRKCD0.25875823
67NEK60.25549201
68CHUK0.24797284
69HCK0.24621429
70MST1R0.24194116
71TGFBR20.23182629
72WEE10.23165960
73FGFR30.21556854
74LYN0.20454899
75ATR0.20173443
76MAP3K10.20008265
77TESK20.19898620
78PRKCG0.19831304
79FGR0.18172971
80PASK0.16253412
81LCK0.14635986
82SYK0.14081298
83STK100.13928066
84GRK10.13182314
85PAK10.11933620
86PIM20.11500026
87ERBB40.10759500
88TTK0.10515355
89ABL10.10269272
90ATM0.09957553
91CHEK10.09686479
92PRKG10.09578197
93EGFR0.09345174
94CHEK20.08831322
95JAK20.08199144
96CSF1R0.08197613
97NTRK10.06965674
98PRKACG0.06213470
99PRKG20.06077960
100DDR20.04945098

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.51281014
2Legionellosis_Homo sapiens_hsa051343.51478670
3Type I diabetes mellitus_Homo sapiens_hsa049402.77346406
4Allograft rejection_Homo sapiens_hsa053302.50975612
5Rheumatoid arthritis_Homo sapiens_hsa053232.44298942
6Dorso-ventral axis formation_Homo sapiens_hsa043202.44153770
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42958948
8Salmonella infection_Homo sapiens_hsa051322.35030610
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33517867
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.28466844
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22215639
12Malaria_Homo sapiens_hsa051442.15887955
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.14785663
14Staphylococcus aureus infection_Homo sapiens_hsa051502.12377862
15Vitamin B6 metabolism_Homo sapiens_hsa007502.00359285
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97138139
17Fatty acid biosynthesis_Homo sapiens_hsa000611.92535644
18Leishmaniasis_Homo sapiens_hsa051401.82838794
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.77277974
20Influenza A_Homo sapiens_hsa051641.71130738
21Antigen processing and presentation_Homo sapiens_hsa046121.69725899
22Measles_Homo sapiens_hsa051621.69644933
23Asthma_Homo sapiens_hsa053101.69243716
24African trypanosomiasis_Homo sapiens_hsa051431.69183461
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66287303
26Pyruvate metabolism_Homo sapiens_hsa006201.55891796
27TNF signaling pathway_Homo sapiens_hsa046681.55659879
28Tuberculosis_Homo sapiens_hsa051521.54351204
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54261748
30Pertussis_Homo sapiens_hsa051331.54085995
31Osteoclast differentiation_Homo sapiens_hsa043801.52229188
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31930809
33Herpes simplex infection_Homo sapiens_hsa051681.28079819
34Mineral absorption_Homo sapiens_hsa049781.27643246
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.27325975
36Linoleic acid metabolism_Homo sapiens_hsa005911.26808384
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24688066
38Autoimmune thyroid disease_Homo sapiens_hsa053201.23259031
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.19559701
40Propanoate metabolism_Homo sapiens_hsa006401.19157757
41Pentose phosphate pathway_Homo sapiens_hsa000301.10373389
42Hematopoietic cell lineage_Homo sapiens_hsa046401.09714497
43Glucagon signaling pathway_Homo sapiens_hsa049221.08290369
44Selenocompound metabolism_Homo sapiens_hsa004501.02984829
45Fanconi anemia pathway_Homo sapiens_hsa034601.02115391
46Prion diseases_Homo sapiens_hsa050200.99773972
47Toxoplasmosis_Homo sapiens_hsa051450.93111223
48Phagosome_Homo sapiens_hsa041450.93004465
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87791988
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84858064
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79491129
52Huntingtons disease_Homo sapiens_hsa050160.77968954
53PPAR signaling pathway_Homo sapiens_hsa033200.77386314
54Glycerolipid metabolism_Homo sapiens_hsa005610.77232841
55Basal transcription factors_Homo sapiens_hsa030220.76726366
56Complement and coagulation cascades_Homo sapiens_hsa046100.76504965
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.75189446
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74750613
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74144784
60Ether lipid metabolism_Homo sapiens_hsa005650.72340177
61Collecting duct acid secretion_Homo sapiens_hsa049660.68852648
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68427667
63B cell receptor signaling pathway_Homo sapiens_hsa046620.60664194
64Arachidonic acid metabolism_Homo sapiens_hsa005900.59127309
65Amphetamine addiction_Homo sapiens_hsa050310.58526338
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.56924779
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54472848
68ABC transporters_Homo sapiens_hsa020100.53941173
69Viral myocarditis_Homo sapiens_hsa054160.53452645
70Chemokine signaling pathway_Homo sapiens_hsa040620.53192860
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51510977
72Oocyte meiosis_Homo sapiens_hsa041140.49919879
73Amoebiasis_Homo sapiens_hsa051460.47904488
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.46833136
75Renin secretion_Homo sapiens_hsa049240.45725587
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44642142
77Systemic lupus erythematosus_Homo sapiens_hsa053220.43442520
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42883516
79Fructose and mannose metabolism_Homo sapiens_hsa000510.41643871
80Hepatitis B_Homo sapiens_hsa051610.41213560
81Hepatitis C_Homo sapiens_hsa051600.35509291
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35412049
83Cardiac muscle contraction_Homo sapiens_hsa042600.33295675
84T cell receptor signaling pathway_Homo sapiens_hsa046600.32947931
85Fat digestion and absorption_Homo sapiens_hsa049750.25436077
86Shigellosis_Homo sapiens_hsa051310.24532727
87Synaptic vesicle cycle_Homo sapiens_hsa047210.23847802
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23813499
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23263623
90Lysosome_Homo sapiens_hsa041420.21941659
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19183495
92Protein digestion and absorption_Homo sapiens_hsa049740.18384482
93Type II diabetes mellitus_Homo sapiens_hsa049300.17596569
94Fatty acid degradation_Homo sapiens_hsa000710.16701016
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13530780
96Calcium signaling pathway_Homo sapiens_hsa040200.13460632
97Epstein-Barr virus infection_Homo sapiens_hsa051690.11869488
98Other glycan degradation_Homo sapiens_hsa005110.10744801
99Estrogen signaling pathway_Homo sapiens_hsa049150.09289501
100Glutathione metabolism_Homo sapiens_hsa004800.09133561

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