ADAM33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.06101701
2type B pancreatic cell proliferation (GO:0044342)5.35277267
3collagen fibril organization (GO:0030199)4.94316307
4extracellular matrix assembly (GO:0085029)4.91602386
5sequestering of extracellular ligand from receptor (GO:0035581)4.76096479
6axon extension involved in axon guidance (GO:0048846)4.62791191
7neuron projection extension involved in neuron projection guidance (GO:1902284)4.62791191
8bone trabecula formation (GO:0060346)4.55556516
9kidney mesenchyme development (GO:0072074)4.46264971
10collagen metabolic process (GO:0032963)4.41793597
11collagen catabolic process (GO:0030574)4.37036896
12extracellular fibril organization (GO:0043206)4.31345922
13cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.27419932
14multicellular organismal macromolecule metabolic process (GO:0044259)4.15988506
15vascular endothelial growth factor signaling pathway (GO:0038084)4.12043035
16multicellular organismal catabolic process (GO:0044243)4.10305592
17glomerular basement membrane development (GO:0032836)4.09828866
18tooth mineralization (GO:0034505)4.06771728
19multicellular organismal metabolic process (GO:0044236)4.03029183
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.92887425
21positive regulation of endothelial cell apoptotic process (GO:2000353)3.79084697
22endocardial cushion development (GO:0003197)3.73012884
23wound healing, spreading of epidermal cells (GO:0035313)3.69603581
24chondrocyte proliferation (GO:0035988)3.66997916
25fibril organization (GO:0097435)3.66616528
26endodermal cell differentiation (GO:0035987)3.65502683
27apoptotic cell clearance (GO:0043277)3.62111273
28cellular response to vitamin (GO:0071295)3.59707566
29virion attachment to host cell (GO:0019062)3.58505396
30adhesion of symbiont to host cell (GO:0044650)3.58505396
31mesenchymal-epithelial cell signaling (GO:0060638)3.53734153
32extracellular matrix disassembly (GO:0022617)3.49356606
33middle ear morphogenesis (GO:0042474)3.45546590
34regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.42846919
35one-carbon compound transport (GO:0019755)3.42352275
36adhesion of symbiont to host (GO:0044406)3.38464686
37keratan sulfate catabolic process (GO:0042340)3.38413771
38cell proliferation involved in kidney development (GO:0072111)3.33452593
39positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.30199707
40cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.27138329
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27063480
42blood vessel maturation (GO:0001955)3.26501876
43regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.23421696
44negative regulation of fatty acid transport (GO:2000192)3.23404192
45cell proliferation involved in metanephros development (GO:0072203)3.18850914
46barbed-end actin filament capping (GO:0051016)3.17309822
47negative regulation of leukocyte chemotaxis (GO:0002689)3.08626168
48regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.04420344
49venous blood vessel morphogenesis (GO:0048845)3.01276343
50negative regulation of stress fiber assembly (GO:0051497)2.99281459
51craniofacial suture morphogenesis (GO:0097094)2.98706341
52extracellular regulation of signal transduction (GO:1900115)2.98289550
53extracellular negative regulation of signal transduction (GO:1900116)2.98289550
54cellular response to interferon-alpha (GO:0035457)2.92447728
55regulation of extracellular matrix disassembly (GO:0010715)2.90005781
56basement membrane organization (GO:0071711)2.89764042
57cellular response to amino acid stimulus (GO:0071230)2.89715606
58positive regulation of fibroblast migration (GO:0010763)2.88966553
59endothelial cell morphogenesis (GO:0001886)2.88525387
60positive regulation of mesenchymal cell proliferation (GO:0002053)2.88147642
61negative regulation of BMP signaling pathway (GO:0030514)2.86739574
62fibroblast migration (GO:0010761)2.85619980
63glial cell migration (GO:0008347)2.84743956
64positive regulation of gastrulation (GO:2000543)2.82134179
65negative regulation of osteoblast proliferation (GO:0033689)2.81993144
66cardiac myofibril assembly (GO:0055003)2.81773593
67desmosome organization (GO:0002934)2.81256501
68protein localization to cell surface (GO:0034394)2.80892252
69stress fiber assembly (GO:0043149)2.80050653
70regulation of integrin-mediated signaling pathway (GO:2001044)2.79782605
71regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.78581442
72pericardium development (GO:0060039)2.78127867
73dermatan sulfate biosynthetic process (GO:0030208)2.77474273
74cell migration involved in sprouting angiogenesis (GO:0002042)2.76885898
75branching involved in salivary gland morphogenesis (GO:0060445)2.76841373
76trabecula formation (GO:0060343)2.75936266
77phagocytosis, recognition (GO:0006910)2.75030719
78negative regulation of complement activation (GO:0045916)2.74540456
79hemidesmosome assembly (GO:0031581)2.73935946
80lung lobe morphogenesis (GO:0060463)2.73738500
81positive regulation of smoothened signaling pathway (GO:0045880)2.72220236
82cell-substrate junction assembly (GO:0007044)2.71138439
83cochlea morphogenesis (GO:0090103)2.70496022
84wound healing, spreading of cells (GO:0044319)2.70362274
85chondroitin sulfate catabolic process (GO:0030207)2.69520152
86epithelial cell-cell adhesion (GO:0090136)2.67271761
87regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.67243194
88hyaluronan catabolic process (GO:0030214)2.67188109
89positive regulation of fatty acid oxidation (GO:0046321)2.66997905
90regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.65724927
91embryonic forelimb morphogenesis (GO:0035115)2.65154998
92negative regulation of embryonic development (GO:0045992)2.64086393
93retina vasculature morphogenesis in camera-type eye (GO:0061299)2.63254748
94positive regulation of fatty acid beta-oxidation (GO:0032000)2.63134741
95regulation of cardiac muscle cell differentiation (GO:2000725)2.62628534
96positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62472085
97negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.62235892
98adherens junction assembly (GO:0034333)2.60922248
99regulation of plasminogen activation (GO:0010755)2.60764416
100detection of molecule of bacterial origin (GO:0032490)2.59764913
101positive regulation of cartilage development (GO:0061036)2.59302335
102Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59098044
103extracellular matrix organization (GO:0030198)2.58442463
104glomerular filtration (GO:0003094)2.57830630
105extracellular structure organization (GO:0043062)2.57261354
106artery morphogenesis (GO:0048844)2.57253343
107focal adhesion assembly (GO:0048041)2.57061800
108cell-substrate adherens junction assembly (GO:0007045)2.57061800
109negative regulation of smooth muscle cell migration (GO:0014912)2.56132129
110skin morphogenesis (GO:0043589)2.55638929
111chondrocyte development (GO:0002063)2.55071113
112growth hormone secretion (GO:0030252)2.54636673
113regulation of mesenchymal cell proliferation (GO:0010464)2.54488132
114dermatan sulfate metabolic process (GO:0030205)2.53398242
115negative regulation of chondrocyte differentiation (GO:0032331)2.51358004
116plasma membrane repair (GO:0001778)2.50696183
117peptide cross-linking (GO:0018149)2.47486441
118positive regulation of glycogen biosynthetic process (GO:0045725)2.46297607
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45574116
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.45574116
121modulation by symbiont of host immune response (GO:0052553)2.45574116
122positive regulation by symbiont of host defense response (GO:0052509)2.45574116
123modulation by symbiont of host defense response (GO:0052031)2.45574116
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45574116
125cell migration involved in heart development (GO:0060973)2.41211428
126embryonic skeletal joint morphogenesis (GO:0060272)2.37306772
127mesonephros development (GO:0001823)2.37105598
128negative regulation of heart growth (GO:0061117)2.36750437
129negative regulation of cardiac muscle tissue growth (GO:0055022)2.36750437
130anatomical structure regression (GO:0060033)2.36317653
131renal filtration (GO:0097205)2.32619794
132positive regulation of p38MAPK cascade (GO:1900745)2.32525498
133positive regulation of cholesterol efflux (GO:0010875)2.32151081
134negative chemotaxis (GO:0050919)2.31940038
135mesenchymal cell proliferation (GO:0010463)2.30695664
136peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.30501513
137mesenchyme morphogenesis (GO:0072132)2.29195133
138cell adhesion mediated by integrin (GO:0033627)2.28915104
139metanephric mesenchyme development (GO:0072075)2.28506382
140outer ear morphogenesis (GO:0042473)2.27307323
141positive regulation of natural killer cell differentiation (GO:0032825)2.27111279
142negative regulation of axon extension involved in axon guidance (GO:0048843)2.27005721
143smooth muscle tissue development (GO:0048745)2.26287008
144myelination in peripheral nervous system (GO:0022011)2.26151210
145peripheral nervous system axon ensheathment (GO:0032292)2.26151210
146negative regulation of cartilage development (GO:0061037)2.24638150
147positive regulation of macrophage cytokine production (GO:0060907)2.23830803
148cranial suture morphogenesis (GO:0060363)2.23394057
149embryonic cranial skeleton morphogenesis (GO:0048701)2.23150535
150regulation of chemokine-mediated signaling pathway (GO:0070099)2.23136299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.48241937
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.73844190
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.54107045
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.52487679
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.11542736
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.54683734
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.18966713
8CJUN_26792858_Chip-Seq_BT549_Human2.01633523
9CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91187896
10CLOCK_20551151_ChIP-Seq_293T_Human1.86907620
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.84701349
12EED_16625203_ChIP-ChIP_MESCs_Mouse1.82632814
13GATA1_22025678_ChIP-Seq_K562_Human1.82291761
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.81142439
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72453803
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72453803
17* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71646664
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63554418
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62249950
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60871262
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60684421
22TP53_18474530_ChIP-ChIP_U2OS_Human1.58168965
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57030956
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.56142829
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54935566
26SMC3_22415368_ChIP-Seq_MEFs_Mouse1.52747424
27NFIB_24661679_ChIP-Seq_LUNG_Mouse1.52622524
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52299421
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51773618
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51719285
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.51597386
32* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50909209
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.49969892
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49251727
35SA1_22415368_ChIP-Seq_MEFs_Mouse1.47974977
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.46832513
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46582832
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46518344
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46304564
40GBX2_23144817_ChIP-Seq_PC3_Human1.45729285
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44521314
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44521314
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43828047
44DROSHA_22980978_ChIP-Seq_HELA_Human1.43006168
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39308968
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38040299
47TP53_16413492_ChIP-PET_HCT116_Human1.37475744
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37172543
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.36939753
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.34566179
51EZH2_22144423_ChIP-Seq_EOC_Human1.34117962
52VDR_24787735_ChIP-Seq_THP-1_Human1.33803714
53* EZH2_27294783_Chip-Seq_ESCs_Mouse1.33341176
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32961104
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31055591
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30481838
57AR_21572438_ChIP-Seq_LNCaP_Human1.30338880
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29483616
59* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29263255
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.29235309
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28690528
62TP53_23651856_ChIP-Seq_MEFs_Mouse1.28528686
63LXR_22292898_ChIP-Seq_THP-1_Human1.28262667
64BRD4_25478319_ChIP-Seq_HGPS_Human1.27865822
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20048646
66RXR_22108803_ChIP-Seq_LS180_Human1.19543945
67SOX2_20726797_ChIP-Seq_SW620_Human1.19490657
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17363308
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17335151
70TP53_22127205_ChIP-Seq_IMR90_Human1.16918052
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.16720865
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15762210
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15762210
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15731044
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15403773
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.14524362
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13702625
78AHR_22903824_ChIP-Seq_MCF-7_Human1.13307467
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12942049
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11338054
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11288942
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.10311769
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.09905552
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09459085
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.09119463
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.09012358
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.07342693
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07133247
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06495673
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.05203217
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05003288
92* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04978275
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04928234
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.04639077
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03895353
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03435577
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02497789
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02301115
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02081865
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01776297
101* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00563140
102* RNF2_27304074_Chip-Seq_ESCs_Mouse0.99981693
103JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98822970
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98603274
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98404055
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.97621562
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.97383262
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.96987667
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.96987667
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96964524
111* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96080836
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95846993
113MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94248320
114* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94154927
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.93369807
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93042888
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91430326
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91009358
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90139184
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90060286
121RACK7_27058665_Chip-Seq_MCF-7_Human0.89999552
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89839875
123KDM2B_26808549_Chip-Seq_K562_Human0.87103886
124CTCF_27219007_Chip-Seq_Bcells_Human0.86735337
125SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86734142
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86531764
127KLF5_25053715_ChIP-Seq_YYC3_Human0.85894616
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85789977
129IRF8_27001747_Chip-Seq_BMDM_Mouse0.85527204
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.84987704
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84964714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.96267691
2MP0005275_abnormal_skin_tensile5.90372837
3MP0005503_abnormal_tendon_morphology4.87936318
4MP0005367_renal/urinary_system_phenotyp4.02920615
5MP0000516_abnormal_urinary_system4.02920615
6MP0003705_abnormal_hypodermis_morpholog3.58023921
7MP0001958_emphysema3.52038300
8MP0010386_abnormal_urinary_bladder3.17933484
9MP0003279_aneurysm2.81685133
10MP0005257_abnormal_intraocular_pressure2.72060929
11MP0002060_abnormal_skin_morphology2.53215302
12MP0004272_abnormal_basement_membrane2.41758896
13MP0000566_synostosis2.37846089
14MP0006054_spinal_hemorrhage2.33927301
15MP0000534_abnormal_ureter_morphology1.96290525
16MP0002138_abnormal_hepatobiliary_system1.86573814
17MP0000751_myopathy1.85281214
18MP0003045_fibrosis1.76319073
19MP0003566_abnormal_cell_adhesion1.74785807
20MP0005508_abnormal_skeleton_morphology1.72562388
21MP0002108_abnormal_muscle_morphology1.70720412
22MP0001243_abnormal_dermal_layer1.70161877
23MP0009384_cardiac_valve_regurgitation1.42148417
24MP0009780_abnormal_chondrocyte_physiolo1.41400547
25MP0001348_abnormal_lacrimal_gland1.39231329
26MP0003950_abnormal_plasma_membrane1.38321394
27MP0002928_abnormal_bile_duct1.35217338
28MP0000569_abnormal_digit_pigmentation1.32775722
29MP0010030_abnormal_orbit_morphology1.31358291
30MP0002295_abnormal_pulmonary_circulatio1.28703088
31MP0004858_abnormal_nervous_system1.24718786
32MP0000767_abnormal_smooth_muscle1.22891683
33MP0003283_abnormal_digestive_organ1.15804994
34MP0005670_abnormal_white_adipose1.15758502
35MP0000749_muscle_degeneration1.14012860
36MP0010368_abnormal_lymphatic_system1.13071853
37MP0000750_abnormal_muscle_regeneration1.11682159
38MP0005023_abnormal_wound_healing1.10440435
39MP0003300_gastrointestinal_ulcer1.08093024
40MP0003385_abnormal_body_wall1.05331057
41MP0005390_skeleton_phenotype1.04822663
42MP0003252_abnormal_bile_duct1.03283767
43MP0001299_abnormal_eye_distance/1.03042682
44MP0001756_abnormal_urination1.01790912
45MP0003941_abnormal_skin_development0.98562481
46MP0009250_abnormal_appendicular_skeleto0.98426993
47MP0002998_abnormal_bone_remodeling0.97944202
48MP0008004_abnormal_stomach_pH0.97269209
49MP0010771_integument_phenotype0.94743440
50MP0004510_myositis0.92474091
51MP0000013_abnormal_adipose_tissue0.91181674
52MP0000733_abnormal_muscle_development0.90875494
53MP0005058_abnormal_lysosome_morphology0.90599485
54MP0000538_abnormal_urinary_bladder0.89644310
55MP0002168_other_aberrant_phenotype0.89005681
56MP0002115_abnormal_skeleton_extremities0.87697086
57MP0001849_ear_inflammation0.87232980
58MP0002896_abnormal_bone_mineralization0.87053311
59MP0005076_abnormal_cell_differentiation0.86856409
60MP0004883_abnormal_blood_vessel0.86675878
61MP0002133_abnormal_respiratory_system0.86224029
62MP0005388_respiratory_system_phenotype0.86224029
63MP0002796_impaired_skin_barrier0.85222872
64MP0002166_altered_tumor_susceptibility0.84361869
65MP0004084_abnormal_cardiac_muscle0.82937174
66MP0005164_abnormal_response_to0.82242798
67MP0002254_reproductive_system_inflammat0.81829606
68MP0004036_abnormal_muscle_relaxation0.81630383
69MP0001542_abnormal_bone_strength0.81588206
70MP0005595_abnormal_vascular_smooth0.80595292
71MP0003115_abnormal_respiratory_system0.80374254
72MP0003942_abnormal_urinary_system0.80325307
73MP0001533_abnormal_skeleton_physiology0.77518728
74MP0002932_abnormal_joint_morphology0.76316938
75MP0000762_abnormal_tongue_morphology0.75791063
76MP0000343_altered_response_to0.75505327
77MP0005369_muscle_phenotype0.74883989
78MP0003091_abnormal_cell_migration0.74518725
79MP0006138_congestive_heart_failure0.73997559
80MP0000579_abnormal_nail_morphology0.73668341
81MP0002116_abnormal_craniofacial_bone0.73075309
82MP0003828_pulmonary_edema0.72608131
83MP0001614_abnormal_blood_vessel0.72089587
84MP0003453_abnormal_keratinocyte_physiol0.71765312
85MP0000462_abnormal_digestive_system0.71579468
86MP0005171_absent_coat_pigmentation0.71566600
87MP0004130_abnormal_muscle_cell0.71458587
88MP0004134_abnormal_chest_morphology0.71007279
89MP0002837_dystrophic_cardiac_calcinosis0.69716002
90MP0002006_tumorigenesis0.69566125
91MP0000163_abnormal_cartilage_morphology0.69408300
92MP0000432_abnormal_head_morphology0.69270453
93MP0002933_joint_inflammation0.68334669
94MP0005620_abnormal_muscle_contractility0.68182379
95MP0001879_abnormal_lymphatic_vessel0.66270714
96MP0001175_abnormal_lung_morphology0.65875088
97MP0000681_abnormal_thyroid_gland0.64914750
98MP0000003_abnormal_adipose_tissue0.64522674
99MP0000428_abnormal_craniofacial_morphol0.64425727
100MP0005623_abnormal_meninges_morphology0.64122482
101MP0000230_abnormal_systemic_arterial0.63961113
102MP0002114_abnormal_axial_skeleton0.63890765
103MP0005220_abnormal_exocrine_pancreas0.63660310
104MP0002109_abnormal_limb_morphology0.63251100
105MP0010352_gastrointestinal_tract_polyps0.62452248
106MP0004145_abnormal_muscle_electrophysio0.61118031
107MP0001270_distended_abdomen0.60842036
108MP0004087_abnormal_muscle_fiber0.60723755
109MP0009053_abnormal_anal_canal0.60564365
110MP0004185_abnormal_adipocyte_glucose0.60513946
111MP0002128_abnormal_blood_circulation0.59875472
112MP0000383_abnormal_hair_follicle0.59594316
113MP0002249_abnormal_larynx_morphology0.59402319
114MP0000759_abnormal_skeletal_muscle0.59199158
115MP0002113_abnormal_skeleton_development0.59198808
116MP0009278_abnormal_bone_marrow0.59135088
117MP0003795_abnormal_bone_structure0.58888160
118MP0000049_abnormal_middle_ear0.58342523
119MP0002282_abnormal_trachea_morphology0.56680841
120MP0002127_abnormal_cardiovascular_syste0.54123099
121MP0005375_adipose_tissue_phenotype0.53364567
122MP0005197_abnormal_uvea_morphology0.52980807
123MP0005330_cardiomyopathy0.52639272
124MP0003755_abnormal_palate_morphology0.52376946
125MP0003448_altered_tumor_morphology0.52263539
126MP0000467_abnormal_esophagus_morphology0.50823673
127MP0002925_abnormal_cardiovascular_devel0.50596820
128MP0000249_abnormal_blood_vessel0.45252214

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.09808015
2Ankle contracture (HP:0006466)5.97057665
3Aortic aneurysm (HP:0004942)5.95244746
4Aortic dissection (HP:0002647)5.87926493
5Premature rupture of membranes (HP:0001788)5.75874646
6Type 1 muscle fiber predominance (HP:0003803)5.20286817
7Broad metatarsal (HP:0001783)4.89152794
8Atrophic scars (HP:0001075)4.65354942
9Cerebral aneurysm (HP:0004944)4.44903328
10Follicular hyperkeratosis (HP:0007502)4.43587265
11Fragile skin (HP:0001030)4.28587529
12Soft skin (HP:0000977)4.10597616
13Shallow orbits (HP:0000586)3.99264665
14Dilatation of the ascending aorta (HP:0005111)3.99194112
15Increased connective tissue (HP:0009025)3.97026108
16Slender build (HP:0001533)3.66744807
17Wrist flexion contracture (HP:0001239)3.57164291
18Peritonitis (HP:0002586)3.50857707
19Spinal rigidity (HP:0003306)3.49896552
20Bladder diverticulum (HP:0000015)3.47406606
21Neoplasm of the heart (HP:0100544)3.31438569
22Short 4th metacarpal (HP:0010044)3.20949070
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.20949070
24Mitral valve prolapse (HP:0001634)3.14096640
25Increased variability in muscle fiber diameter (HP:0003557)3.00311010
26Vertebral compression fractures (HP:0002953)2.94952006
27Mildly elevated creatine phosphokinase (HP:0008180)2.89508395
28Wormian bones (HP:0002645)2.85072418
29Osteolytic defects of the hand bones (HP:0009699)2.79762461
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.79762461
31Abnormality of the 4th metacarpal (HP:0010012)2.78191923
32Cervical subluxation (HP:0003308)2.75055632
33Neonatal short-limb short stature (HP:0008921)2.69454388
34Aneurysm (HP:0002617)2.66916166
35Abnormality of skeletal muscle fiber size (HP:0012084)2.64885765
36Aortic regurgitation (HP:0001659)2.60328642
37Aortic valve stenosis (HP:0001650)2.59337152
38Mild short stature (HP:0003502)2.54375786
39Blue sclerae (HP:0000592)2.53222850
40Vascular tortuosity (HP:0004948)2.51989322
41Mesomelia (HP:0003027)2.49920295
42Muscle fiber splitting (HP:0003555)2.45214008
43Right ventricular cardiomyopathy (HP:0011663)2.44127459
44Elbow flexion contracture (HP:0002987)2.42765369
45Hyperextensible skin (HP:0000974)2.40135042
46Breech presentation (HP:0001623)2.34863881
47Alopecia of scalp (HP:0002293)2.32396874
48Joint stiffness (HP:0001387)2.31879722
49Abnormality of the acetabulum (HP:0003170)2.30198248
50Nonimmune hydrops fetalis (HP:0001790)2.29974752
51Ulnar bowing (HP:0003031)2.27676236
52Pulmonary artery stenosis (HP:0004415)2.27366252
53Joint laxity (HP:0001388)2.26707765
54Arterial tortuosity (HP:0005116)2.22846865
55Milia (HP:0001056)2.22721181
56Biconcave vertebral bodies (HP:0004586)2.22578175
57Redundant skin (HP:0001582)2.22279846
58Emphysema (HP:0002097)2.21647281
59Genu recurvatum (HP:0002816)2.20634173
60Infantile muscular hypotonia (HP:0008947)2.19814496
61Persistence of primary teeth (HP:0006335)2.18667975
62Camptodactyly of toe (HP:0001836)2.17837055
63Round ear (HP:0100830)2.14978492
64Striae distensae (HP:0001065)2.13363351
65Narrow nasal bridge (HP:0000446)2.12677260
66Absent frontal sinuses (HP:0002688)2.12347280
67Coronal craniosynostosis (HP:0004440)2.11963107
68Hip contracture (HP:0003273)2.11496886
69Tarsal synostosis (HP:0008368)2.09977996
70Gastrointestinal dysmotility (HP:0002579)2.08923589
71Stridor (HP:0010307)2.07873020
72Turricephaly (HP:0000262)2.07563033
73Mitral regurgitation (HP:0001653)2.07555678
74Wide anterior fontanel (HP:0000260)2.05126846
75Abnormality of the parietal bone (HP:0002696)2.04951613
76Abnormality of dentin (HP:0010299)2.04593466
77Delayed closure of the anterior fontanelle (HP:0001476)2.02174857
78Natal tooth (HP:0000695)2.01390300
79Bell-shaped thorax (HP:0001591)2.00687526
80Inguinal hernia (HP:0000023)1.98796674
81Abnormal delivery (HP:0001787)1.98366919
82Generalized amyotrophy (HP:0003700)1.97728350
83Delayed cranial suture closure (HP:0000270)1.96264456
84Ectopia lentis (HP:0001083)1.94465231
85Sparse lateral eyebrow (HP:0005338)1.94386728
86Protruding ear (HP:0000411)1.92234248
87Knee flexion contracture (HP:0006380)1.91861015
88Scapular winging (HP:0003691)1.91752899
89Malnutrition (HP:0004395)1.91481326
90Deformed tarsal bones (HP:0008119)1.91223074
91Synostosis involving bones of the lower limbs (HP:0009138)1.90982345
92Synostosis involving bones of the feet (HP:0009140)1.90982345
93Calcaneovalgus deformity (HP:0001848)1.89858083
94Bowel diverticulosis (HP:0005222)1.88705673
95Ulnar deviation of the wrist (HP:0003049)1.87634328
96Aplasia involving bones of the upper limbs (HP:0009823)1.85807049
97Aplasia of the phalanges of the hand (HP:0009802)1.85807049
98Aplasia involving bones of the extremities (HP:0009825)1.85807049
99Abnormality of skull ossification (HP:0002703)1.84158687
100Venous insufficiency (HP:0005293)1.83640508
101Obstructive sleep apnea (HP:0002870)1.83003055
102Hypoventilation (HP:0002791)1.82700469
103Limb-girdle muscle weakness (HP:0003325)1.82585151
104Limited hip movement (HP:0008800)1.82450560
105Osteoarthritis (HP:0002758)1.82317348
106Venous abnormality (HP:0002624)1.82257436
107Morphological abnormality of the middle ear (HP:0008609)1.81798776
108Long toe (HP:0010511)1.81138946
109Premature skin wrinkling (HP:0100678)1.80925465
110Short hallux (HP:0010109)1.80562392
111Hypoplasia of the iris (HP:0007676)1.79266496
112Flexion contracture of toe (HP:0005830)1.76744552
113Joint contractures involving the joints of the feet (HP:0100492)1.76744552
114Thin bony cortex (HP:0002753)1.76487336
115Ovoid vertebral bodies (HP:0003300)1.76020187
116Deviation of the hallux (HP:0010051)1.74934271
117Broad ribs (HP:0000885)1.74901542
118Distal lower limb muscle weakness (HP:0009053)1.74588124
119Flat cornea (HP:0007720)1.74188044
120Abnormal ossification of hand bones (HP:0005921)1.73987758
121Hallux valgus (HP:0001822)1.73562910
122Spondylolisthesis (HP:0003302)1.73512519
123Overgrowth (HP:0001548)1.73481880
124Flared iliac wings (HP:0002869)1.72503786
125Broad long bones (HP:0005622)1.72008545
126Disproportionate tall stature (HP:0001519)1.71273227
127Thin skin (HP:0000963)1.70957358
128Gingival overgrowth (HP:0000212)1.70832861
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68336119
130Broad toe (HP:0001837)1.67374096
131Spinal cord lesions (HP:0100561)1.65316853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.78835502
2MYLK4.74294707
3TRIB32.97292089
4DDR22.96353743
5TGFBR22.69389366
6EPHA32.34663726
7ERN12.34045222
8AKT32.32630520
9DMPK2.27843343
10EPHB12.06588919
11PDGFRA2.04769433
12EPHB22.03881496
13FGFR42.00416947
14FGFR21.99021092
15LATS11.98115234
16PIK3CG1.87243440
17SIK11.86785865
18RIPK11.86454018
19TESK11.77712689
20CAMK1D1.74660336
21NTRK11.73920928
22PAK21.73062706
23GRK51.55232784
24PIK3CA1.44686721
25TRPM71.43089870
26CAMK1G1.41671990
27LIMK11.35854909
28GRK11.30478985
29LMTK21.30293752
30ADRBK11.29636290
31PTK2B1.27900941
32STK381.23920890
33ABL21.20161431
34MST1R1.18903726
35MAPK151.18012774
36FGFR31.16788851
37NUAK11.15660530
38PTK21.14554201
39FER1.13994024
40LATS21.12658606
41OBSCN1.08350960
42BMX1.07316048
43MET1.06992106
44MARK21.03676749
45MAP3K141.03386075
46JAK10.93838074
47CDC42BPA0.93795564
48MAP3K30.93353986
49MAP3K100.93083993
50DAPK20.91251415
51ADRBK20.90931939
52PDGFRB0.90391599
53RPS6KA20.88617486
54MAPK120.84621149
55PTK60.83803887
56MAPK70.82825557
57TIE10.82524810
58MAP3K20.78842910
59DAPK30.78560397
60FLT30.73211018
61ROCK10.73000299
62FGFR10.71399545
63TBK10.69815309
64PKN20.68268674
65ROCK20.67768801
66JAK30.66483650
67MOS0.63334236
68PRKCH0.61324807
69PRPF4B0.60477672
70ILK0.60195530
71GSK3A0.60107498
72MAPK40.59034048
73PHKG20.58942782
74PHKG10.58942782
75MAPKAPK30.58702285
76RPS6KL10.58487408
77RPS6KC10.58487408
78CAMK2G0.58050986
79PRKD30.57937369
80RPS6KA60.56382384
81ZAK0.55403249
82ERBB20.55312691
83PAK40.55182222
84PRKG20.54716187
85HIPK20.54695836
86MTOR0.53616315
87TYK20.53025710
88MAP2K10.52589251
89ERBB30.51164443
90GRK60.51155370
91MAP2K30.51009297
92PIM20.50786385
93PAK60.50380475
94KIT0.48942382
95MAP3K70.47433142
96IKBKB0.47007578
97CHUK0.45158412
98PLK20.44824303
99MAPKAPK50.44175999
100STK30.44003081
101ICK0.43422069
102CSK0.42579380
103PRKD10.42465987
104PAK30.42401869
105INSRR0.42031543
106CLK10.41597368
107PAK10.41446894
108PRKAA20.40904013
109ERBB40.40192109
110PDK20.39921676
111IRAK30.39871252
112PRKCE0.38700490
113PRKD20.38088458
114MAPKAPK20.37843990
115RET0.37366647
116GRK70.37173290
117PRKCI0.37037422
118FRK0.36779894
119NEK90.36377598
120EIF2AK20.36243223
121WNK10.35743705
122SRC0.35510102
123NLK0.34962993
124MAP3K60.33838961
125EEF2K0.33774789
126MAP2K40.33305885
127CAMK10.32139220
128MARK10.32095154
129MELK0.32075131
130MAPK10.31907470
131MAP2K20.31279099
132TGFBR10.29856875
133PDPK10.26570711
134SMG10.25340693
135CAMK2D0.24912687
136INSR0.24187458

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.59358358
2Protein digestion and absorption_Homo sapiens_hsa049743.31269262
3Focal adhesion_Homo sapiens_hsa045102.41211451
4Amoebiasis_Homo sapiens_hsa051461.98550755
5Malaria_Homo sapiens_hsa051441.91223901
6Basal cell carcinoma_Homo sapiens_hsa052171.86178322
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79747061
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78736410
9Bladder cancer_Homo sapiens_hsa052191.72201233
10Dilated cardiomyopathy_Homo sapiens_hsa054141.68720755
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68484553
12Proteoglycans in cancer_Homo sapiens_hsa052051.68257976
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.53759689
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.46957481
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41850683
16Staphylococcus aureus infection_Homo sapiens_hsa051501.38113391
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.37166030
18Toxoplasmosis_Homo sapiens_hsa051451.35688102
19Phospholipase D signaling pathway_Homo sapiens_hsa040721.35568148
20Small cell lung cancer_Homo sapiens_hsa052221.35292543
21Adherens junction_Homo sapiens_hsa045201.31605831
22Lysosome_Homo sapiens_hsa041421.30172417
23Hedgehog signaling pathway_Homo sapiens_hsa043401.27373096
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21269074
25Osteoclast differentiation_Homo sapiens_hsa043801.19802010
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19226723
27Platelet activation_Homo sapiens_hsa046111.16164388
28Pertussis_Homo sapiens_hsa051331.12592896
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12505485
30Melanoma_Homo sapiens_hsa052181.11193511
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10954149
32Gap junction_Homo sapiens_hsa045401.10750996
33TNF signaling pathway_Homo sapiens_hsa046681.10678680
34Other glycan degradation_Homo sapiens_hsa005111.09874355
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07696045
36Leishmaniasis_Homo sapiens_hsa051401.07616806
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07312516
38Insulin resistance_Homo sapiens_hsa049311.06282702
39Pancreatic secretion_Homo sapiens_hsa049721.05588225
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05415350
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.04196154
42Caffeine metabolism_Homo sapiens_hsa002321.03999620
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.99082476
44TGF-beta signaling pathway_Homo sapiens_hsa043500.97021501
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95727037
46Complement and coagulation cascades_Homo sapiens_hsa046100.94563444
47Notch signaling pathway_Homo sapiens_hsa043300.93850844
48Viral myocarditis_Homo sapiens_hsa054160.92618788
49Tuberculosis_Homo sapiens_hsa051520.91148802
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90507927
51Estrogen signaling pathway_Homo sapiens_hsa049150.90399692
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89968998
53Hippo signaling pathway_Homo sapiens_hsa043900.88010292
54Pathways in cancer_Homo sapiens_hsa052000.85575915
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85108463
56Chronic myeloid leukemia_Homo sapiens_hsa052200.83713701
57Salmonella infection_Homo sapiens_hsa051320.83065756
58Phagosome_Homo sapiens_hsa041450.81554582
59Rheumatoid arthritis_Homo sapiens_hsa053230.80249980
60Cocaine addiction_Homo sapiens_hsa050300.79008368
61cAMP signaling pathway_Homo sapiens_hsa040240.78413188
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74710326
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.74689600
64MicroRNAs in cancer_Homo sapiens_hsa052060.74301746
65PPAR signaling pathway_Homo sapiens_hsa033200.73923896
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72633980
67Renin-angiotensin system_Homo sapiens_hsa046140.72243926
68Ras signaling pathway_Homo sapiens_hsa040140.72071732
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71371221
70Prostate cancer_Homo sapiens_hsa052150.70977487
71Rap1 signaling pathway_Homo sapiens_hsa040150.69645890
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69016694
73Pancreatic cancer_Homo sapiens_hsa052120.68925433
74Insulin signaling pathway_Homo sapiens_hsa049100.68674451
75Apoptosis_Homo sapiens_hsa042100.68486425
76GnRH signaling pathway_Homo sapiens_hsa049120.68209649
77Influenza A_Homo sapiens_hsa051640.68037252
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67100270
79Choline metabolism in cancer_Homo sapiens_hsa052310.66943912
80mTOR signaling pathway_Homo sapiens_hsa041500.66543105
81Acute myeloid leukemia_Homo sapiens_hsa052210.65811982
82Tight junction_Homo sapiens_hsa045300.64791451
83Gastric acid secretion_Homo sapiens_hsa049710.64772755
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64178218
85African trypanosomiasis_Homo sapiens_hsa051430.62824603
86AMPK signaling pathway_Homo sapiens_hsa041520.61719055
87Axon guidance_Homo sapiens_hsa043600.61705130
88Hepatitis C_Homo sapiens_hsa051600.61516192
89Sphingolipid metabolism_Homo sapiens_hsa006000.61512176
90Melanogenesis_Homo sapiens_hsa049160.60671914
91Type II diabetes mellitus_Homo sapiens_hsa049300.60171305
92Insulin secretion_Homo sapiens_hsa049110.58681928
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57526139
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57183078
95Wnt signaling pathway_Homo sapiens_hsa043100.57171001
96Endocytosis_Homo sapiens_hsa041440.56561073
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.55351376
98Arachidonic acid metabolism_Homo sapiens_hsa005900.54770213
99Oxytocin signaling pathway_Homo sapiens_hsa049210.54505798
100Hepatitis B_Homo sapiens_hsa051610.54489436
101Thyroid hormone synthesis_Homo sapiens_hsa049180.54448546
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54245613
103Vitamin digestion and absorption_Homo sapiens_hsa049770.53710144
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53409423
105Cholinergic synapse_Homo sapiens_hsa047250.53234210
106HTLV-I infection_Homo sapiens_hsa051660.53005615
107Renin secretion_Homo sapiens_hsa049240.52804267
108Fat digestion and absorption_Homo sapiens_hsa049750.51758951
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51740065
110Ovarian steroidogenesis_Homo sapiens_hsa049130.51313615
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51212115
112Glioma_Homo sapiens_hsa052140.50677622
113Prion diseases_Homo sapiens_hsa050200.49441745
114Lysine degradation_Homo sapiens_hsa003100.48599162
115Calcium signaling pathway_Homo sapiens_hsa040200.48466666
116FoxO signaling pathway_Homo sapiens_hsa040680.48044246
117MAPK signaling pathway_Homo sapiens_hsa040100.47918663
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47467513
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.46875589
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46479224
121HIF-1 signaling pathway_Homo sapiens_hsa040660.46121771
122Shigellosis_Homo sapiens_hsa051310.45927527
123Endometrial cancer_Homo sapiens_hsa052130.45837801
124Legionellosis_Homo sapiens_hsa051340.45473318
125Circadian entrainment_Homo sapiens_hsa047130.44858864
126Salivary secretion_Homo sapiens_hsa049700.42595682
127Prolactin signaling pathway_Homo sapiens_hsa049170.37985314
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37501967
129Amphetamine addiction_Homo sapiens_hsa050310.35393777
130VEGF signaling pathway_Homo sapiens_hsa043700.34934806
131Renal cell carcinoma_Homo sapiens_hsa052110.34026086
132Dorso-ventral axis formation_Homo sapiens_hsa043200.33870215

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