ADAM3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: germ-cell specific metalloprotease-disintegrin that may play a role in cell-cell and cell-matrix interactions during spermatogenesis [RGD, Feb 2006]. SAMEA2689604, SAMN02642708 [ECO:0000348] NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.12882300
2L-fucose catabolic process (GO:0042355)4.26668540
3fucose catabolic process (GO:0019317)4.26668540
4L-fucose metabolic process (GO:0042354)4.26668540
5behavioral response to nicotine (GO:0035095)4.06310491
6multicellular organism reproduction (GO:0032504)3.84931905
7adaptation of signaling pathway (GO:0023058)3.84160787
8protein K11-linked deubiquitination (GO:0035871)3.69258243
9indolalkylamine metabolic process (GO:0006586)3.65948853
10detection of light stimulus involved in sensory perception (GO:0050962)3.59472341
11detection of light stimulus involved in visual perception (GO:0050908)3.59472341
12dopamine transport (GO:0015872)3.58814077
13piRNA metabolic process (GO:0034587)3.51742253
14platelet dense granule organization (GO:0060155)3.48534154
15tryptophan catabolic process (GO:0006569)3.44530081
16indole-containing compound catabolic process (GO:0042436)3.44530081
17indolalkylamine catabolic process (GO:0046218)3.44530081
18protein polyglutamylation (GO:0018095)3.43457197
19DNA deamination (GO:0045006)3.42190197
20kynurenine metabolic process (GO:0070189)3.42124121
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36841432
22signal peptide processing (GO:0006465)3.35722073
23acrosome reaction (GO:0007340)3.32552453
24axoneme assembly (GO:0035082)3.25138853
25tryptophan metabolic process (GO:0006568)3.21773957
26inositol phosphate catabolic process (GO:0071545)3.19183276
27regulation of action potential (GO:0098900)3.09855328
28cellular ketone body metabolic process (GO:0046950)3.09466369
29establishment of protein localization to Golgi (GO:0072600)3.06945298
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06874079
31sperm motility (GO:0030317)3.02860632
32DNA double-strand break processing (GO:0000729)3.02039413
33neural tube formation (GO:0001841)3.01816081
34transmission of nerve impulse (GO:0019226)2.96277182
35water-soluble vitamin biosynthetic process (GO:0042364)2.95792283
36cilium or flagellum-dependent cell motility (GO:0001539)2.94208881
37epithelial cilium movement (GO:0003351)2.93968421
38behavioral response to ethanol (GO:0048149)2.85448750
39reflex (GO:0060004)2.84551436
40ketone body metabolic process (GO:1902224)2.84212589
41respiratory chain complex IV assembly (GO:0008535)2.83834717
42mannosylation (GO:0097502)2.83095035
43inositol phosphate dephosphorylation (GO:0046855)2.82566728
44phosphorylated carbohydrate dephosphorylation (GO:0046838)2.82566728
45preassembly of GPI anchor in ER membrane (GO:0016254)2.82540281
46neuronal action potential (GO:0019228)2.78218781
47negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78081666
48photoreceptor cell maintenance (GO:0045494)2.77865002
49male meiosis (GO:0007140)2.77122131
50retinal cone cell development (GO:0046549)2.76828876
51protein targeting to Golgi (GO:0000042)2.76749678
52DNA methylation involved in gamete generation (GO:0043046)2.73812676
53regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73366959
54basic amino acid transport (GO:0015802)2.71059692
55negative regulation of mast cell activation (GO:0033004)2.69894445
56protein localization to cilium (GO:0061512)2.69138175
57protein-cofactor linkage (GO:0018065)2.68884315
58cytochrome complex assembly (GO:0017004)2.68829461
59synapsis (GO:0007129)2.64446292
60double-strand break repair via homologous recombination (GO:0000724)2.64409228
61recombinational repair (GO:0000725)2.63594590
62cellular response to ATP (GO:0071318)2.63477776
63synaptic transmission, cholinergic (GO:0007271)2.63011054
64replication fork processing (GO:0031297)2.62550475
65polyol catabolic process (GO:0046174)2.62388091
66protein prenylation (GO:0018342)2.61320346
67prenylation (GO:0097354)2.61320346
68amine catabolic process (GO:0009310)2.60529871
69cellular biogenic amine catabolic process (GO:0042402)2.60529871
70cilium morphogenesis (GO:0060271)2.60273956
71regulation of memory T cell differentiation (GO:0043380)2.58800565
72rhodopsin mediated signaling pathway (GO:0016056)2.57760789
73branched-chain amino acid catabolic process (GO:0009083)2.55458845
74indole-containing compound metabolic process (GO:0042430)2.55170164
75regulation of cilium movement (GO:0003352)2.53330746
76regulation of sarcomere organization (GO:0060297)2.52961396
77phosphatidylinositol acyl-chain remodeling (GO:0036149)2.51495352
78auditory receptor cell stereocilium organization (GO:0060088)2.49951663
79protein complex biogenesis (GO:0070271)2.49773747
80cornea development in camera-type eye (GO:0061303)2.49352649
81reciprocal meiotic recombination (GO:0007131)2.47565678
82reciprocal DNA recombination (GO:0035825)2.47565678
83protein localization to Golgi apparatus (GO:0034067)2.46055654
84magnesium ion transport (GO:0015693)2.44956727
85cilium organization (GO:0044782)2.43535325
86reproduction (GO:0000003)2.40372472
87cilium movement (GO:0003341)2.39629617
88male meiosis I (GO:0007141)2.38913127
89intra-S DNA damage checkpoint (GO:0031573)2.38832112
90S-adenosylmethionine metabolic process (GO:0046500)2.38755302
91cell wall macromolecule metabolic process (GO:0044036)2.38053731
92DNA integration (GO:0015074)2.37870227
93fusion of sperm to egg plasma membrane (GO:0007342)2.37864985
94seminiferous tubule development (GO:0072520)2.37662629
95GPI anchor metabolic process (GO:0006505)2.36784441
96visual perception (GO:0007601)2.36427321
97sensory perception of light stimulus (GO:0050953)2.35718075
98retrograde transport, vesicle recycling within Golgi (GO:0000301)2.35653385
99benzene-containing compound metabolic process (GO:0042537)2.35237794
100cilium assembly (GO:0042384)2.34348316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.59713937
2VDR_22108803_ChIP-Seq_LS180_Human3.56808531
3GBX2_23144817_ChIP-Seq_PC3_Human2.87832321
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67969846
5IGF1R_20145208_ChIP-Seq_DFB_Human2.60818177
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56730315
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53867951
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.43774376
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37415500
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.32776646
11P300_19829295_ChIP-Seq_ESCs_Human2.23401607
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22453919
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15649090
14* FUS_26573619_Chip-Seq_HEK293_Human2.08585212
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08347860
16ER_23166858_ChIP-Seq_MCF-7_Human2.02800243
17EWS_26573619_Chip-Seq_HEK293_Human2.01341044
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95595110
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90193292
20TAF15_26573619_Chip-Seq_HEK293_Human1.87528595
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87436111
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.77727334
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76570120
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.68902998
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67038986
26CBP_20019798_ChIP-Seq_JUKART_Human1.67038986
27SMAD4_21799915_ChIP-Seq_A2780_Human1.65430715
28STAT3_23295773_ChIP-Seq_U87_Human1.62719240
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61954322
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58329741
31TP53_22573176_ChIP-Seq_HFKS_Human1.55254601
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52288208
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50938296
34SOX2_19829295_ChIP-Seq_ESCs_Human1.50643786
35NANOG_19829295_ChIP-Seq_ESCs_Human1.50643786
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49299258
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.49037962
38BCAT_22108803_ChIP-Seq_LS180_Human1.48655383
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47775427
40TCF4_23295773_ChIP-Seq_U87_Human1.46215682
41AR_25329375_ChIP-Seq_VCAP_Human1.45239726
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44143031
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43137109
44IRF1_19129219_ChIP-ChIP_H3396_Human1.42833946
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.42283630
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41229267
47EZH2_22144423_ChIP-Seq_EOC_Human1.39842746
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39790445
49FOXA1_21572438_ChIP-Seq_LNCaP_Human1.39094933
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39079615
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37663160
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.37356482
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36510367
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36281579
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36281579
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33235173
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32518354
58TCF4_22108803_ChIP-Seq_LS180_Human1.31931641
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.29327949
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29327949
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29234449
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28022876
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27303850
64RUNX2_22187159_ChIP-Seq_PCA_Human1.25958421
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.25570966
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22318523
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21887264
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21606154
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21293551
70CDX2_22108803_ChIP-Seq_LS180_Human1.20708718
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.20190899
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.20115095
73* GATA3_21878914_ChIP-Seq_MCF-7_Human1.19855869
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.19674887
75AR_20517297_ChIP-Seq_VCAP_Human1.19132447
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.19055822
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18037680
78NCOR_22424771_ChIP-Seq_293T_Human1.15674984
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.14322321
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14182593
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08501625
82GATA3_26560356_Chip-Seq_TH2_Human1.08242918
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08118664
84AR_21572438_ChIP-Seq_LNCaP_Human1.07628132
85P53_22387025_ChIP-Seq_ESCs_Mouse1.07598836
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07509294
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06119818
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05564010
89HOXB7_26014856_ChIP-Seq_BT474_Human1.03365602
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03361759
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03275955
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01831049
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01656674
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.99747527
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98949668
96PHF8_20622853_ChIP-Seq_HELA_Human0.98255801
97NFYB_21822215_ChIP-Seq_K562_Human0.97893702
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.97730767
99ETV1_20927104_ChIP-Seq_GIST48_Human0.97519382
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.97452651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.45334001
2MP0000372_irregular_coat_pigmentation3.34978187
3MP0008877_abnormal_DNA_methylation3.17678958
4MP0002102_abnormal_ear_morphology3.12032192
5MP0002837_dystrophic_cardiac_calcinosis2.97834006
6MP0006072_abnormal_retinal_apoptosis2.77615391
7MP0005551_abnormal_eye_electrophysiolog2.62329744
8MP0000569_abnormal_digit_pigmentation2.30592240
9MP0005410_abnormal_fertilization2.18194973
10MP0005379_endocrine/exocrine_gland_phen2.15768844
11MP0005253_abnormal_eye_physiology2.09379341
12MP0003136_yellow_coat_color1.99456713
13MP0001968_abnormal_touch/_nociception1.93063976
14MP0003787_abnormal_imprinting1.92965390
15MP0005377_hearing/vestibular/ear_phenot1.88599115
16MP0003878_abnormal_ear_physiology1.88599115
17MP0005174_abnormal_tail_pigmentation1.87866648
18MP0002876_abnormal_thyroid_physiology1.87007913
19MP0003950_abnormal_plasma_membrane1.86408989
20MP0008872_abnormal_physiological_respon1.86048758
21MP0003646_muscle_fatigue1.80331676
22MP0003011_delayed_dark_adaptation1.77095011
23MP0001501_abnormal_sleep_pattern1.76870737
24MP0002163_abnormal_gland_morphology1.76079911
25MP0001485_abnormal_pinna_reflex1.70970717
26MP0009046_muscle_twitch1.65214521
27MP0005646_abnormal_pituitary_gland1.54327824
28MP0001986_abnormal_taste_sensitivity1.53304457
29MP0008875_abnormal_xenobiotic_pharmacok1.53253219
30MP0002736_abnormal_nociception_after1.52956584
31MP0009780_abnormal_chondrocyte_physiolo1.50975232
32MP0005645_abnormal_hypothalamus_physiol1.50402551
33MP0009745_abnormal_behavioral_response1.49787762
34MP0001486_abnormal_startle_reflex1.48569957
35MP0001529_abnormal_vocalization1.40849281
36MP0000427_abnormal_hair_cycle1.36403236
37MP0002095_abnormal_skin_pigmentation1.36078152
38MP0002938_white_spotting1.33456638
39MP0003880_abnormal_central_pattern1.32199000
40MP0002138_abnormal_hepatobiliary_system1.31725726
41MP0001835_abnormal_antigen_presentation1.29149235
42MP0004147_increased_porphyrin_level1.26531645
43MP0004145_abnormal_muscle_electrophysio1.25725095
44MP0005075_abnormal_melanosome_morpholog1.23307500
45MP0004885_abnormal_endolymph1.21319081
46MP0001984_abnormal_olfaction1.18540396
47MP0008995_early_reproductive_senescence1.15941287
48MP0002272_abnormal_nervous_system1.15919179
49MP0004215_abnormal_myocardial_fiber1.15909868
50MP0005389_reproductive_system_phenotype1.13897999
51MP0002638_abnormal_pupillary_reflex1.13092750
52MP0000015_abnormal_ear_pigmentation1.12410559
53MP0003252_abnormal_bile_duct1.10882268
54MP0008775_abnormal_heart_ventricle1.10869398
55MP0002928_abnormal_bile_duct1.09739074
56MP0002277_abnormal_respiratory_mucosa1.09618996
57MP0004133_heterotaxia1.09015036
58MP0003698_abnormal_male_reproductive1.07107233
59MP0002557_abnormal_social/conspecific_i1.06064282
60MP0004043_abnormal_pH_regulation1.05929576
61MP0005171_absent_coat_pigmentation1.05772267
62MP0000631_abnormal_neuroendocrine_gland1.05604666
63MP0009697_abnormal_copulation1.05366056
64MP0005084_abnormal_gallbladder_morpholo1.05019750
65MP0003718_maternal_effect1.03265305
66MP0002168_other_aberrant_phenotype1.03151452
67MP0001929_abnormal_gametogenesis1.02100775
68MP0004924_abnormal_behavior1.00900377
69MP0005386_behavior/neurological_phenoty1.00900377
70MP0005360_urolithiasis1.00420560
71MP0006276_abnormal_autonomic_nervous0.99687612
72MP0002909_abnormal_adrenal_gland0.98776588
73MP0004084_abnormal_cardiac_muscle0.97132596
74MP0002160_abnormal_reproductive_system0.96687399
75MP0002254_reproductive_system_inflammat0.96517990
76MP0005671_abnormal_response_to0.95713135
77MP0006292_abnormal_olfactory_placode0.95102860
78MP0001970_abnormal_pain_threshold0.94771519
79MP0000230_abnormal_systemic_arterial0.94580378
80MP0001764_abnormal_homeostasis0.94451004
81MP0010386_abnormal_urinary_bladder0.94351357
82MP0003045_fibrosis0.94222651
83MP0002572_abnormal_emotion/affect_behav0.93446785
84MP0001919_abnormal_reproductive_system0.89485175
85MP0006054_spinal_hemorrhage0.89157463
86MP0005395_other_phenotype0.88091734
87MP0005332_abnormal_amino_acid0.87292198
88MP0009764_decreased_sensitivity_to0.86494912
89MP0002693_abnormal_pancreas_physiology0.86446395
90MP0010329_abnormal_lipoprotein_level0.83138165
91MP0004742_abnormal_vestibular_system0.81720721
92MP0002733_abnormal_thermal_nociception0.81475593
93MP0002067_abnormal_sensory_capabilities0.80159856
94MP0004142_abnormal_muscle_tone0.77971413
95MP0002735_abnormal_chemical_nociception0.77969192
96MP0000647_abnormal_sebaceous_gland0.77740393
97MP0000538_abnormal_urinary_bladder0.77604534
98MP0002229_neurodegeneration0.76242131
99MP0001756_abnormal_urination0.76043444
100MP0002064_seizures0.75082785

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)4.59130434
2Attenuation of retinal blood vessels (HP:0007843)4.27108207
3Hypothermia (HP:0002045)4.18827423
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.99537595
5Pancreatic cysts (HP:0001737)3.71620904
6Congenital stationary night blindness (HP:0007642)3.61720931
7Abnormality of midbrain morphology (HP:0002418)3.57404707
8Molar tooth sign on MRI (HP:0002419)3.57404707
9True hermaphroditism (HP:0010459)3.55425345
10Pancreatic fibrosis (HP:0100732)3.50010573
11Nephronophthisis (HP:0000090)3.33963344
12Chronic hepatic failure (HP:0100626)3.30369646
13Abnormality of the renal cortex (HP:0011035)3.25948152
14Bony spicule pigmentary retinopathy (HP:0007737)3.25706855
15Chronic otitis media (HP:0000389)3.20898173
16Decreased central vision (HP:0007663)3.16480152
17Absent/shortened dynein arms (HP:0200106)3.12386978
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.12386978
19Pendular nystagmus (HP:0012043)3.11061513
20Medial flaring of the eyebrow (HP:0010747)2.99145988
21Keratoconus (HP:0000563)2.97253694
22Increased corneal curvature (HP:0100692)2.97253694
23Abnormality of the renal medulla (HP:0100957)2.89743344
24Abolished electroretinogram (ERG) (HP:0000550)2.89622225
25Chronic sinusitis (HP:0011109)2.74586419
26Constricted visual fields (HP:0001133)2.72538920
27Renal cortical cysts (HP:0000803)2.72345391
28Hyperalaninemia (HP:0003348)2.67961411
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67961411
30Abnormality of alanine metabolism (HP:0010916)2.67961411
31Type II lissencephaly (HP:0007260)2.63740632
32Stomach cancer (HP:0012126)2.59623254
33Abnormal drinking behavior (HP:0030082)2.59200498
34Polydipsia (HP:0001959)2.59200498
35Tubular atrophy (HP:0000092)2.47098151
36Abnormality of macular pigmentation (HP:0008002)2.43630972
37Inability to walk (HP:0002540)2.39886775
38Hypoproteinemia (HP:0003075)2.38501465
39Aplasia/Hypoplasia of the fovea (HP:0008060)2.34025223
40Hypoplasia of the fovea (HP:0007750)2.34025223
41Cystic liver disease (HP:0006706)2.33270602
42Hyperventilation (HP:0002883)2.29612194
43Gaze-evoked nystagmus (HP:0000640)2.29279607
44Hemiparesis (HP:0001269)2.26892704
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23564764
46Progressive cerebellar ataxia (HP:0002073)2.20532527
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.20447445
48Absent speech (HP:0001344)2.19609850
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.17120862
50Abnormal respiratory epithelium morphology (HP:0012253)2.16238183
51Abnormal respiratory motile cilium morphology (HP:0005938)2.16238183
52Thyroiditis (HP:0100646)2.15334657
53Progressive inability to walk (HP:0002505)2.14814568
54Polyuria (HP:0000103)2.09556647
55Abnormal ciliary motility (HP:0012262)2.08881479
56Congenital sensorineural hearing impairment (HP:0008527)2.07062427
57Abnormality of the fovea (HP:0000493)2.04774701
58Intestinal atresia (HP:0011100)2.01603174
59Dialeptic seizures (HP:0011146)2.00869390
60Focal motor seizures (HP:0011153)2.00781257
61Hypoalbuminemia (HP:0003073)1.96443715
62Abnormal albumin level (HP:0012116)1.96443715
63Optic disc pallor (HP:0000543)1.95823242
64Anencephaly (HP:0002323)1.95058148
65Focal seizures (HP:0007359)1.94017708
66Severe visual impairment (HP:0001141)1.93354925
67Type 2 muscle fiber atrophy (HP:0003554)1.92791083
68Congenital hepatic fibrosis (HP:0002612)1.92245060
69Progressive macrocephaly (HP:0004481)1.92212890
70Sclerocornea (HP:0000647)1.91686686
71Lissencephaly (HP:0001339)1.91030458
72Congenital primary aphakia (HP:0007707)1.88904541
73Gait imbalance (HP:0002141)1.88295627
74Febrile seizures (HP:0002373)1.87144908
75Furrowed tongue (HP:0000221)1.87079060
76Small hand (HP:0200055)1.85627034
77Disproportionate short-trunk short stature (HP:0003521)1.84948865
78Tubulointerstitial nephritis (HP:0001970)1.84425267
79Bile duct proliferation (HP:0001408)1.83395361
80Abnormal biliary tract physiology (HP:0012439)1.83395361
81Acute necrotizing encephalopathy (HP:0006965)1.82397346
82Hypomagnesemia (HP:0002917)1.80722817
83Postaxial foot polydactyly (HP:0001830)1.80032013
84Stomatitis (HP:0010280)1.79816755
85Atonic seizures (HP:0010819)1.79530542
86Abnormality of B cell number (HP:0010975)1.79515553
87Albinism (HP:0001022)1.79163039
88Decreased circulating renin level (HP:0003351)1.78867509
89Tubulointerstitial abnormality (HP:0001969)1.78403433
90Short tibia (HP:0005736)1.78356476
91Nasal polyposis (HP:0100582)1.77004410
92Recurrent bronchitis (HP:0002837)1.76952336
93Amelogenesis imperfecta (HP:0000705)1.74493963
94Bronchiectasis (HP:0002110)1.74120288
95Photophobia (HP:0000613)1.73729558
96Male pseudohermaphroditism (HP:0000037)1.73224326
97Increased CSF lactate (HP:0002490)1.72658414
98Concave nail (HP:0001598)1.68897829
99Mitochondrial inheritance (HP:0001427)1.67447873
100Nephrogenic diabetes insipidus (HP:0009806)1.66464705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.71400516
2MAP4K23.34275651
3NUAK12.83843597
4BMPR1B2.72713665
5WNK32.61197176
6ADRBK22.50789930
7TLK12.30979906
8ZAK2.30810027
9MAP3K132.29270269
10MAP3K122.08821576
11PINK12.01029741
12ACVR1B1.99379003
13GRK11.98697675
14MUSK1.94444175
15TAOK31.89673057
16EIF2AK31.87721379
17PLK41.86609954
18TXK1.71715423
19MAPK131.71291865
20PLK21.71187515
21INSRR1.68138223
22TRIM281.63404729
23PAK31.56718834
24WNK41.41557482
25OXSR11.36017983
26MAPKAPK31.28971571
27MST41.25201862
28STK391.21074735
29DAPK21.18236938
30IKBKB1.17313358
31PRKCE1.08839872
32MKNK21.08639745
33ERBB31.07168812
34FER1.03836054
35CASK1.02642275
36MAP3K41.02327695
37MAP3K140.95449393
38BMPR20.94448174
39PTK2B0.90893132
40MAPKAPK50.90027300
41MARK10.89146506
42STK38L0.84856767
43PLK30.82995651
44FGFR20.80946436
45EPHA30.78541560
46PHKG10.78492835
47PHKG20.78492835
48VRK10.77036169
49MAP2K60.76715294
50BRSK20.74706981
51PRKCG0.73187290
52PRKCQ0.71928449
53CSNK1G20.71570919
54TIE10.71295508
55BCR0.70684763
56ADRBK10.69842395
57TEC0.69564643
58PIK3CG0.66174122
59CSNK1G10.65734997
60IRAK10.65720233
61TNIK0.63555960
62PIK3CA0.63138042
63STK30.60237152
64NTRK30.58625015
65CAMKK20.56340978
66TNK20.54312012
67STK160.53537784
68TGFBR10.53278146
69CSNK1G30.49276555
70TRPM70.49264217
71MKNK10.48385053
72MARK30.48362101
73ITK0.47663219
74CCNB10.47100806
75DYRK20.46613139
76NLK0.46355920
77CHUK0.46176723
78CAMK2A0.45781405
79MAP3K90.44939346
80PRKCI0.44771499
81TAF10.42996451
82PRKAA20.41914571
83MAP2K10.41880544
84CDK80.40867691
85AKT30.40744394
86PKN10.40490558
87CSNK1D0.39518045
88CSNK1A1L0.38866880
89MYLK0.36732836
90OBSCN0.36339399
91MAP4K10.35728370
92PRKACA0.35677082
93KIT0.35552555
94IGF1R0.35348224
95NME10.34566060
96PNCK0.34140428
97SYK0.32165837
98ABL10.32126841
99EIF2AK20.30529859
100PRKCA0.30326531

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.76186035
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.73539883
3Linoleic acid metabolism_Homo sapiens_hsa005912.56558296
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51617335
5Butanoate metabolism_Homo sapiens_hsa006502.38148144
6Nitrogen metabolism_Homo sapiens_hsa009102.35809458
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31645268
8Selenocompound metabolism_Homo sapiens_hsa004502.26964292
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.26450205
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08829630
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07239194
12Protein export_Homo sapiens_hsa030602.00665153
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00401891
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98185146
15Ether lipid metabolism_Homo sapiens_hsa005651.89826469
16Tryptophan metabolism_Homo sapiens_hsa003801.82898189
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.72197994
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70548445
19Propanoate metabolism_Homo sapiens_hsa006401.64998841
20Caffeine metabolism_Homo sapiens_hsa002321.58877397
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.58064073
22Basal transcription factors_Homo sapiens_hsa030221.49483029
23Homologous recombination_Homo sapiens_hsa034401.48918935
24Olfactory transduction_Homo sapiens_hsa047401.41737274
25Asthma_Homo sapiens_hsa053101.37074927
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36564732
27Nicotine addiction_Homo sapiens_hsa050331.31510936
28Type I diabetes mellitus_Homo sapiens_hsa049401.28907168
29Oxidative phosphorylation_Homo sapiens_hsa001901.28312373
30ABC transporters_Homo sapiens_hsa020101.22004147
31Morphine addiction_Homo sapiens_hsa050321.14751889
32Fanconi anemia pathway_Homo sapiens_hsa034601.11508706
33Chemical carcinogenesis_Homo sapiens_hsa052041.08979848
34RNA polymerase_Homo sapiens_hsa030201.08750911
35Retinol metabolism_Homo sapiens_hsa008301.08568412
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.07803881
37Taste transduction_Homo sapiens_hsa047421.06299262
38Sulfur metabolism_Homo sapiens_hsa009201.06067956
39Serotonergic synapse_Homo sapiens_hsa047261.05288962
40Graft-versus-host disease_Homo sapiens_hsa053321.05102007
41Peroxisome_Homo sapiens_hsa041461.04891652
42Fatty acid degradation_Homo sapiens_hsa000711.04690154
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03330931
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03096151
45Arachidonic acid metabolism_Homo sapiens_hsa005901.02169239
46Primary immunodeficiency_Homo sapiens_hsa053401.00642966
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98152904
48Insulin secretion_Homo sapiens_hsa049110.98097892
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97164794
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94960416
51Parkinsons disease_Homo sapiens_hsa050120.93357790
52Allograft rejection_Homo sapiens_hsa053300.92739842
53RNA degradation_Homo sapiens_hsa030180.92391681
54Collecting duct acid secretion_Homo sapiens_hsa049660.91647084
55One carbon pool by folate_Homo sapiens_hsa006700.91200116
56Circadian entrainment_Homo sapiens_hsa047130.89493045
57Proteasome_Homo sapiens_hsa030500.88201971
58Fatty acid metabolism_Homo sapiens_hsa012120.87965787
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85798301
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85060335
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83895740
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.83088987
63Non-homologous end-joining_Homo sapiens_hsa034500.82772051
64Autoimmune thyroid disease_Homo sapiens_hsa053200.81736467
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80881923
66Mineral absorption_Homo sapiens_hsa049780.79524665
67Salivary secretion_Homo sapiens_hsa049700.78768976
68GABAergic synapse_Homo sapiens_hsa047270.78265718
69Dorso-ventral axis formation_Homo sapiens_hsa043200.77975351
70beta-Alanine metabolism_Homo sapiens_hsa004100.77890879
71Glycerolipid metabolism_Homo sapiens_hsa005610.76802615
72Fat digestion and absorption_Homo sapiens_hsa049750.68969540
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68823067
74Glutamatergic synapse_Homo sapiens_hsa047240.68622452
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68018968
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67332109
77Rheumatoid arthritis_Homo sapiens_hsa053230.67168619
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64865808
79Ovarian steroidogenesis_Homo sapiens_hsa049130.64822314
80Calcium signaling pathway_Homo sapiens_hsa040200.63831458
81Regulation of autophagy_Homo sapiens_hsa041400.63027488
82Circadian rhythm_Homo sapiens_hsa047100.61813440
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61580456
84Purine metabolism_Homo sapiens_hsa002300.59640687
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.58792221
86Fatty acid biosynthesis_Homo sapiens_hsa000610.56438431
87Sphingolipid metabolism_Homo sapiens_hsa006000.56196370
88Metabolic pathways_Homo sapiens_hsa011000.55506516
89Huntingtons disease_Homo sapiens_hsa050160.48216958
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.48105828
91Cardiac muscle contraction_Homo sapiens_hsa042600.46105359
92Fatty acid elongation_Homo sapiens_hsa000620.42267926
93Alzheimers disease_Homo sapiens_hsa050100.37394887
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37081363
95Long-term depression_Homo sapiens_hsa047300.36371996
96Antigen processing and presentation_Homo sapiens_hsa046120.36086828
97Amphetamine addiction_Homo sapiens_hsa050310.35310147
98Dopaminergic synapse_Homo sapiens_hsa047280.34374172
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.34357816
100cAMP signaling pathway_Homo sapiens_hsa040240.33505133

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