ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	4.87425119
2	behavioral response to nicotine (GO:0035095)	4.72776542
3	facial nerve structural organization (GO:0021612)	4.68239530
4	neurotransmitter-gated ion channel clustering (GO:0072578)	4.64866773
5	proline transport (GO:0015824)	4.54554384
6	regulation of timing of cell differentiation (GO:0048505)	4.52155900
7	regulation of development, heterochronic (GO:0040034)	4.49973502
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.43191706
9	limb development (GO:0060173)	4.41361874
10	appendage development (GO:0048736)	4.41361874
11	regulation of translation, ncRNA-mediated (GO:0045974)	4.38335054
12	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.38335054
13	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.38335054
14	peristalsis (GO:0030432)	4.25488029
15	cranial nerve structural organization (GO:0021604)	4.10315664
16	heparin metabolic process (GO:0030202)	4.09107348
17	heparin biosynthetic process (GO:0030210)	4.09107348
18	negative regulation of astrocyte differentiation (GO:0048712)	4.02913733
19	DNA double-strand break processing (GO:0000729)	3.97570279
20	presynaptic membrane organization (GO:0097090)	3.96861774
21	nonmotile primary cilium assembly (GO:0035058)	3.95578076
22	epithelial cilium movement (GO:0003351)	3.93921573
23	olfactory bulb development (GO:0021772)	3.93149176
24	retinal ganglion cell axon guidance (GO:0031290)	3.83496018
25	regulation of collateral sprouting (GO:0048670)	3.82438705
26	neural tube formation (GO:0001841)	3.81385693
27	pyrimidine nucleobase catabolic process (GO:0006208)	3.76917305
28	protein polyglutamylation (GO:0018095)	3.72873722
29	C4-dicarboxylate transport (GO:0015740)	3.71455372
30	transmission of nerve impulse (GO:0019226)	3.58372987
31	dorsal/ventral axis specification (GO:0009950)	3.52807024
32	central nervous system projection neuron axonogenesis (GO:0021952)	3.51295259
33	photoreceptor cell maintenance (GO:0045494)	3.32631196
34	regulation of axon regeneration (GO:0048679)	3.30866086
35	regulation of neuron projection regeneration (GO:0070570)	3.30866086
36	behavioral response to ethanol (GO:0048149)	3.30373751
37	fucose catabolic process (GO:0019317)	3.28923667
38	L-fucose metabolic process (GO:0042354)	3.28923667
39	L-fucose catabolic process (GO:0042355)	3.28923667
40	gamma-aminobutyric acid transport (GO:0015812)	3.15980322
41	negative regulation of systemic arterial blood pressure (GO:0003085)	3.13630680
42	hindbrain development (GO:0030902)	3.10846621
43	cilium morphogenesis (GO:0060271)	3.09512170
44	microtubule depolymerization (GO:0007019)	3.09414395
45	inner ear receptor stereocilium organization (GO:0060122)	3.07119046
46	central nervous system neuron axonogenesis (GO:0021955)	3.06668670
47	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)	3.05153236
48	phasic smooth muscle contraction (GO:0014821)	3.00409621
49	mechanosensory behavior (GO:0007638)	2.99555738
50	axonal fasciculation (GO:0007413)	2.98858255
51	cilium or flagellum-dependent cell motility (GO:0001539)	2.98542037
52	cilium movement (GO:0003341)	2.96330865
53	cilium assembly (GO:0042384)	2.95194060
54	nucleobase catabolic process (GO:0046113)	2.92300907
55	anatomical structure arrangement (GO:0048532)	2.91981329
56	cilium organization (GO:0044782)	2.91550062
57	retina layer formation (GO:0010842)	2.89548283
58	limb bud formation (GO:0060174)	2.89397900
59	negative regulation of DNA recombination (GO:0045910)	2.82767299
60	spinal cord development (GO:0021510)	2.80909283
61	postsynaptic membrane organization (GO:0001941)	2.80629487
62	neuronal ion channel clustering (GO:0045161)	2.79053314
63	establishment of nucleus localization (GO:0040023)	2.78576820
64	neuron fate specification (GO:0048665)	2.77498037
65	neuron fate determination (GO:0048664)	2.73372598
66	intraciliary transport (GO:0042073)	2.72113124
67	neuron recognition (GO:0008038)	2.70253145
68	cornea development in camera-type eye (GO:0061303)	2.70065005
69	organelle disassembly (GO:1903008)	2.69943306
70	response to pheromone (GO:0019236)	2.68365310
71	melanosome transport (GO:0032402)	2.68049104
72	cerebral cortex radially oriented cell migration (GO:0021799)	2.66495958
73	smoothened signaling pathway (GO:0007224)	2.65003420
74	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.63563358
75	forebrain neuron differentiation (GO:0021879)	2.63427374
76	resolution of meiotic recombination intermediates (GO:0000712)	2.63399586
77	pyrimidine dimer repair (GO:0006290)	2.62531469
78	somite development (GO:0061053)	2.62356826
79	microtubule polymerization or depolymerization (GO:0031109)	2.61553129
80	adult walking behavior (GO:0007628)	2.61244197
81	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.61017445
82	pigment granule transport (GO:0051904)	2.60718745
83	head development (GO:0060322)	2.59255359
84	establishment of melanosome localization (GO:0032401)	2.58613575
85	ventricular system development (GO:0021591)	2.58036729
86	mitotic sister chromatid cohesion (GO:0007064)	2.55958718
87	proximal/distal pattern formation (GO:0009954)	2.55803971
88	indole-containing compound catabolic process (GO:0042436)	2.54878455
89	indolalkylamine catabolic process (GO:0046218)	2.54878455
90	tryptophan catabolic process (GO:0006569)	2.54878455
91	regulation of cilium movement (GO:0003352)	2.54726943
92	negative regulation of glial cell differentiation (GO:0045686)	2.53861347
93	vocalization behavior (GO:0071625)	2.53587997
94	ectoderm development (GO:0007398)	2.53152694
95	establishment of pigment granule localization (GO:0051905)	2.52012168
96	regulation of helicase activity (GO:0051095)	2.51995796
97	melanosome localization (GO:0032400)	2.51716545
98	RNA polyadenylation (GO:0043631)	2.47246058
99	pigment granule localization (GO:0051875)	2.45919132
100	startle response (GO:0001964)	2.45261660

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.92292583
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.85962056
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.57490396
4	TAF15_26573619_Chip-Seq_HEK293_Human	3.47425296
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.01554062
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.98330299
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.64472663
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.62389570
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.60275257
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57743807
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.43182261
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.42512836
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.38365507
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.28895637
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.28895637
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.23476878
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.19483852
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.13052192
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12502133
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12274229
21	EWS_26573619_Chip-Seq_HEK293_Human	2.10331042
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.09966280
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09029128
24	FUS_26573619_Chip-Seq_HEK293_Human	2.08074171
25	P300_19829295_ChIP-Seq_ESCs_Human	2.04225436
26	VDR_22108803_ChIP-Seq_LS180_Human	1.92714928
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.91416294
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.85527615
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.82140030
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79625310
31	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.78371188
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.74155454
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.62485753
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61439222
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60775351
36	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59570163
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58733811
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58221148
39	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.56456543
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53317944
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51035161
42	AR_25329375_ChIP-Seq_VCAP_Human	1.47616454
43	STAT3_23295773_ChIP-Seq_U87_Human	1.46244412
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.46086776
45	TCF4_23295773_ChIP-Seq_U87_Human	1.45492754
46	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.44407453
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44097937
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43154174
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42091975
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.40546858
51	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40452347
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38871845
53	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.38078287
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.37409597
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.35415620
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.33627856
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.33515134
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30462781
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28524461
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27083434
61	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.26425884
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.24291037
63	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.23375002
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23282193
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22947426
66	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.21660742
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21365625
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.20397532
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20397532
70	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.20318689
71	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19608686
72	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.19486574
73	SOX9_26525672_Chip-Seq_HEART_Mouse	1.18440223
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17559664
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17104175
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.13945894
77	RXR_22108803_ChIP-Seq_LS180_Human	1.12998329
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.11259294
79	KDM2B_26808549_Chip-Seq_REH_Human	1.11035166
80	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.10958569
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09942250
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09261385
83	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07930614
84	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07930614
85	TP53_16413492_ChIP-PET_HCT116_Human	1.07650358
86	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.07244087
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06451581
88	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06369600
89	JUN_21703547_ChIP-Seq_K562_Human	1.05260190
90	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.04218171
91	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03315165
92	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.03172700
93	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02992737
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02879127
95	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.02603170
96	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.02488767
97	MYC_18940864_ChIP-ChIP_HL60_Human	1.02201057
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01711742
99	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.98905171
100	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97910026

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.20111253
2	MP0002822_catalepsy	3.02835232
3	MP0008057_abnormal_DNA_replication	2.72493456
4	MP0001529_abnormal_vocalization	2.56551247
5	MP0000778_abnormal_nervous_system	2.51682824
6	MP0003787_abnormal_imprinting	2.49411334
7	MP0002736_abnormal_nociception_after	2.44031330
8	MP0006072_abnormal_retinal_apoptosis	2.40769632
9	MP0002102_abnormal_ear_morphology	2.38233081
10	MP0005386_behavior/neurological_phenoty	2.37985555
11	MP0004924_abnormal_behavior	2.37985555
12	MP0001486_abnormal_startle_reflex	2.32484108
13	MP0005253_abnormal_eye_physiology	2.30072041
14	MP0001968_abnormal_touch/_nociception	2.26069586
15	MP0009046_muscle_twitch	2.16324377
16	MP0005167_abnormal_blood-brain_barrier	2.10215358
17	MP0000569_abnormal_digit_pigmentation	2.03209514
18	MP0002272_abnormal_nervous_system	1.93813358
19	MP0008877_abnormal_DNA_methylation	1.89819880
20	MP0002938_white_spotting	1.89601023
21	MP0001485_abnormal_pinna_reflex	1.89100255
22	MP0004742_abnormal_vestibular_system	1.82586292
23	MP0005551_abnormal_eye_electrophysiolog	1.81298012
24	MP0006276_abnormal_autonomic_nervous	1.79858461
25	MP0002734_abnormal_mechanical_nocicepti	1.78153737
26	MP0002067_abnormal_sensory_capabilities	1.56774842
27	MP0004133_heterotaxia	1.56461767
28	MP0003635_abnormal_synaptic_transmissio	1.52566363
29	MP0009745_abnormal_behavioral_response	1.51911037
30	MP0001984_abnormal_olfaction	1.50062768
31	MP0004142_abnormal_muscle_tone	1.48633447
32	MP0002752_abnormal_somatic_nervous	1.45933954
33	MP0001905_abnormal_dopamine_level	1.45071190
34	MP0006292_abnormal_olfactory_placode	1.44072225
35	MP0002557_abnormal_social/conspecific_i	1.42788367
36	MP0000566_synostosis	1.41294773
37	MP0000049_abnormal_middle_ear	1.37154284
38	MP0003121_genomic_imprinting	1.36495761
39	MP0002063_abnormal_learning/memory/cond	1.33685664
40	MP0002751_abnormal_autonomic_nervous	1.33134802
41	MP0005187_abnormal_penis_morphology	1.28454872
42	MP0002064_seizures	1.26856590
43	MP0005195_abnormal_posterior_eye	1.25251526
44	MP0008058_abnormal_DNA_repair	1.25240608
45	MP0002882_abnormal_neuron_morphology	1.23567787
46	MP0002572_abnormal_emotion/affect_behav	1.23182372
47	MP0008789_abnormal_olfactory_epithelium	1.22813382
48	MP0005248_abnormal_Harderian_gland	1.22353805
49	MP0003890_abnormal_embryonic-extraembry	1.21501189
50	MP0004215_abnormal_myocardial_fiber	1.20558454
51	MP0002254_reproductive_system_inflammat	1.20434251
52	MP0002184_abnormal_innervation	1.20147807
53	MP0005391_vision/eye_phenotype	1.18931112
54	MP0002733_abnormal_thermal_nociception	1.16836367
55	MP0000955_abnormal_spinal_cord	1.16158682
56	MP0001177_atelectasis	1.14652227
57	MP0001970_abnormal_pain_threshold	1.13525413
58	MP0001293_anophthalmia	1.12381866
59	MP0004885_abnormal_endolymph	1.12168467
60	MP0000647_abnormal_sebaceous_gland	1.11003783
61	MP0002233_abnormal_nose_morphology	1.10235307
62	MP0003567_abnormal_fetal_cardiomyocyte	1.09226274
63	MP0003861_abnormal_nervous_system	1.07958608
64	MP0003937_abnormal_limbs/digits/tail_de	1.07682823
65	MP0000026_abnormal_inner_ear	1.07393548
66	MP0004270_analgesia	1.06824158
67	MP0003011_delayed_dark_adaptation	1.05984647
68	MP0002152_abnormal_brain_morphology	1.05827189
69	MP0004859_abnormal_synaptic_plasticity	1.04701976
70	MP0010386_abnormal_urinary_bladder	1.02506205
71	MP0000631_abnormal_neuroendocrine_gland	1.02100246
72	MP0001963_abnormal_hearing_physiology	0.99759532
73	MP0005394_taste/olfaction_phenotype	0.99316000
74	MP0005499_abnormal_olfactory_system	0.99316000
75	MP0003698_abnormal_male_reproductive	0.99207847
76	MP0003718_maternal_effect	0.98216666
77	MP0003755_abnormal_palate_morphology	0.98007131
78	MP0004043_abnormal_pH_regulation	0.97613431
79	MP0003122_maternal_imprinting	0.91071843
80	MP0004811_abnormal_neuron_physiology	0.90170241
81	MP0002111_abnormal_tail_morphology	0.89781019
82	MP0000428_abnormal_craniofacial_morphol	0.89096501
83	MP0003137_abnormal_impulse_conducting	0.89063176
84	MP0000751_myopathy	0.88325444
85	MP0000534_abnormal_ureter_morphology	0.87678901
86	MP0003136_yellow_coat_color	0.86797579
87	MP0004145_abnormal_muscle_electrophysio	0.86673327
88	MP0003632_abnormal_nervous_system	0.86348190
89	MP0002234_abnormal_pharynx_morphology	0.84361983
90	MP0003315_abnormal_perineum_morphology	0.84262607
91	MP0000427_abnormal_hair_cycle	0.83419719
92	MP0003385_abnormal_body_wall	0.82542599
93	MP0009697_abnormal_copulation	0.81005325
94	MP0002066_abnormal_motor_capabilities/c	0.80909537
95	MP0003119_abnormal_digestive_system	0.80032834
96	MP0002735_abnormal_chemical_nociception	0.79593862
97	MP0000749_muscle_degeneration	0.79471040
98	MP0006035_abnormal_mitochondrial_morpho	0.79455128
99	MP0002095_abnormal_skin_pigmentation	0.76939163
100	MP0009703_decreased_birth_body	0.75876990

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gait imbalance (HP:0002141)	4.01217732
2	Congenital primary aphakia (HP:0007707)	3.96933631
3	Medial flaring of the eyebrow (HP:0010747)	3.93914135
4	Pancreatic fibrosis (HP:0100732)	3.74764104
5	Pancreatic cysts (HP:0001737)	3.72905152
6	True hermaphroditism (HP:0010459)	3.48170291
7	Nephrogenic diabetes insipidus (HP:0009806)	3.44210450
8	Hyperventilation (HP:0002883)	3.41050771
9	Genital tract atresia (HP:0001827)	3.38881030
10	Vaginal atresia (HP:0000148)	3.38878563
11	Chronic hepatic failure (HP:0100626)	3.27641053
12	Volvulus (HP:0002580)	3.20264681
13	Nephronophthisis (HP:0000090)	3.19168150
14	Abnormality of midbrain morphology (HP:0002418)	3.14410816
15	Molar tooth sign on MRI (HP:0002419)	3.14410816
16	Intestinal atresia (HP:0011100)	3.05496493
17	Broad foot (HP:0001769)	3.00034349
18	Poor coordination (HP:0002370)	2.97464230
19	Optic nerve hypoplasia (HP:0000609)	2.87936268
20	Cerebellar dysplasia (HP:0007033)	2.76689242
21	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.75708174
22	Short 4th metacarpal (HP:0010044)	2.75708174
23	Pendular nystagmus (HP:0012043)	2.74123936
24	Cutaneous finger syndactyly (HP:0010554)	2.69672256
25	Cystic liver disease (HP:0006706)	2.66705350
26	Colon cancer (HP:0003003)	2.62869862
27	Abnormality of the renal medulla (HP:0100957)	2.62844851
28	Postaxial hand polydactyly (HP:0001162)	2.53782213
29	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.50608741
30	Renal hypoplasia (HP:0000089)	2.45591827
31	Type II lissencephaly (HP:0007260)	2.44192295
32	Anencephaly (HP:0002323)	2.42311235
33	Cutaneous syndactyly (HP:0012725)	2.37628725
34	Absent speech (HP:0001344)	2.35342254
35	Drooling (HP:0002307)	2.34901167
36	Hypoplastic pelvis (HP:0008839)	2.26474240
37	Tented upper lip vermilion (HP:0010804)	2.26107425
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25239829
39	Anophthalmia (HP:0000528)	2.24246220
40	Limb hypertonia (HP:0002509)	2.23608661
41	Narrow forehead (HP:0000341)	2.23021103
42	Lissencephaly (HP:0001339)	2.21469856
43	Decreased testicular size (HP:0008734)	2.17429472
44	Preaxial hand polydactyly (HP:0001177)	2.16347186
45	Abnormality of the labia minora (HP:0012880)	2.16321913
46	Decreased circulating renin level (HP:0003351)	2.15666828
47	Abnormality of the 4th metacarpal (HP:0010012)	2.14352139
48	Congenital hepatic fibrosis (HP:0002612)	2.11813233
49	Excessive salivation (HP:0003781)	2.11803141
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.11256585
51	Postaxial foot polydactyly (HP:0001830)	2.09559160
52	Sclerocornea (HP:0000647)	2.08849914
53	Short foot (HP:0001773)	2.07616001
54	Oligodactyly (hands) (HP:0001180)	2.06306064
55	Dandy-Walker malformation (HP:0001305)	2.05365093
56	Hypokalemic alkalosis (HP:0001949)	2.05300188
57	Focal seizures (HP:0007359)	2.04617939
58	Abnormality of the metopic suture (HP:0005556)	2.03362781
59	Astigmatism (HP:0000483)	2.02849887
60	Epidermoid cyst (HP:0200040)	2.02841237
61	Prominent nasal bridge (HP:0000426)	2.01367068
62	Aplasia/Hypoplasia of the lens (HP:0008063)	1.98941392
63	Decreased central vision (HP:0007663)	1.97970800
64	Keratoconus (HP:0000563)	1.97570041
65	Increased corneal curvature (HP:0100692)	1.97570041
66	Bile duct proliferation (HP:0001408)	1.97375541
67	Abnormal biliary tract physiology (HP:0012439)	1.97375541
68	Broad-based gait (HP:0002136)	1.95889195
69	Patellar aplasia (HP:0006443)	1.95580370
70	Retinal dysplasia (HP:0007973)	1.95418989
71	Micropenis (HP:0000054)	1.94702866
72	Thyroid-stimulating hormone excess (HP:0002925)	1.94631822
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.89952068
74	Abnormality of the antihelix (HP:0009738)	1.89224105
75	Abolished electroretinogram (ERG) (HP:0000550)	1.88617087
76	Megalencephaly (HP:0001355)	1.88202905
77	Rib fusion (HP:0000902)	1.87882541
78	Aganglionic megacolon (HP:0002251)	1.87691469
79	Male pseudohermaphroditism (HP:0000037)	1.86324435
80	Chorioretinal coloboma (HP:0000567)	1.85104074
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.81826988
82	Focal motor seizures (HP:0011153)	1.79784271
83	Specific learning disability (HP:0001328)	1.79273590
84	Abnormality of DNA repair (HP:0003254)	1.78649581
85	Attenuation of retinal blood vessels (HP:0007843)	1.78475868
86	Myelomeningocele (HP:0002475)	1.77831778
87	Meningocele (HP:0002435)	1.77812135
88	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.76596985
89	Left ventricular hypertrophy (HP:0001712)	1.75274672
90	Gaze-evoked nystagmus (HP:0000640)	1.75032592
91	Gastrointestinal atresia (HP:0002589)	1.74914464
92	Abnormality of the ileum (HP:0001549)	1.72378544
93	Progressive cerebellar ataxia (HP:0002073)	1.72159596
94	Multicystic kidney dysplasia (HP:0000003)	1.71758501
95	Hypoplastic iliac wings (HP:0002866)	1.71544232
96	Nonprogressive disorder (HP:0003680)	1.71451990
97	Febrile seizures (HP:0002373)	1.71319562
98	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.70292000
99	Abnormality of the astrocytes (HP:0100707)	1.68662571
100	Astrocytoma (HP:0009592)	1.68662571

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	4.26169787
2	NTRK3	4.16296685
3	FRK	4.04908034
4	CASK	3.99430711
5	EPHA4	3.80939522
6	MAP3K4	3.32659754
7	GRK1	3.20691891
8	MAPK13	3.17805370
9	DYRK3	2.56126261
10	SRPK1	2.27179764
11	MAP2K7	2.23814682
12	MARK1	2.06361509
13	MKNK2	2.04326844
14	RPS6KA4	1.97298438
15	NUAK1	1.94291446
16	BCR	1.66310902
17	MKNK1	1.63625510
18	WNK3	1.51582517
19	DYRK2	1.48933101
20	MAP4K2	1.41965643
21	CDC7	1.29119336
22	ZAK	1.25218363
23	CAMK4	1.21917751
24	CCNB1	1.17453645
25	CSNK1G2	1.15888780
26	PNCK	1.14498584
27	DYRK1B	1.07654309
28	TRIM28	1.03686904
29	DMPK	1.03132010
30	SGK2	1.01534816
31	BRSK2	1.01079212
32	UHMK1	0.99088390
33	CSNK1G3	0.96833335
34	CDK3	0.92342868
35	STK39	0.90351479
36	PLK3	0.88643954
37	CSNK1G1	0.88414093
38	STK16	0.87826492
39	IRAK1	0.82051951
40	CSNK1A1L	0.78306411
41	TYRO3	0.75984582
42	WNK4	0.75752876
43	CAMKK2	0.75485152
44	OXSR1	0.72670040
45	CAMK2A	0.72320198
46	MAP2K4	0.69994311
47	RAF1	0.69843891
48	ERBB3	0.69620060
49	NEK1	0.68624022
50	PLK2	0.68529974
51	CAMK1G	0.68185682
52	ATR	0.67806131
53	PLK4	0.67519521
54	MAPKAPK5	0.66056766
55	TNIK	0.65573881
56	MAP3K6	0.64099943
57	CDK9	0.63096881
58	PAK3	0.63076007
59	PINK1	0.62878751
60	SGK223	0.61637862
61	SGK494	0.61637862
62	SGK3	0.61606735
63	RPS6KA5	0.57966574
64	CHEK2	0.56407377
65	CAMK2B	0.56351224
66	DYRK1A	0.55863698
67	ATM	0.54867736
68	NTRK2	0.54497462
69	PKN1	0.54244193
70	PRKCE	0.53156604
71	IRAK2	0.52548201
72	INSRR	0.52149179
73	BMPR1B	0.51504656
74	PIK3CA	0.47331459
75	PRKG1	0.46566329
76	FER	0.44043475
77	PLK1	0.43739773
78	VRK1	0.42576429
79	EPHB2	0.41284122
80	PRKDC	0.40620094
81	PRKCG	0.40531630
82	CDK19	0.39899692
83	CDK5	0.39866157
84	NEK2	0.39825788
85	TAF1	0.39725118
86	BRSK1	0.39027524
87	NME1	0.39001624
88	MINK1	0.38762759
89	CAMK2D	0.38673704
90	RPS6KA6	0.36326746
91	WEE1	0.34415466
92	PRKACA	0.33493783
93	BRAF	0.32023273
94	GRK5	0.31427325
95	CSNK1E	0.31426484
96	AURKB	0.29522752
97	CSNK1A1	0.28903372
98	CAMK1D	0.27420641
99	RPS6KA2	0.26636822
100	RPS6KC1	0.25904501

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.39238558
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.42074468
3	Phototransduction_Homo sapiens_hsa04744	2.66409235
4	Taste transduction_Homo sapiens_hsa04742	2.47923142
5	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.42381357
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.41476039
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.21853909
8	Propanoate metabolism_Homo sapiens_hsa00640	2.20101072
9	Butanoate metabolism_Homo sapiens_hsa00650	2.16458759
10	Basal transcription factors_Homo sapiens_hsa03022	2.10302839
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.05400310
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.00333054
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.94124893
14	Morphine addiction_Homo sapiens_hsa05032	1.88847302
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.88229794
16	Protein export_Homo sapiens_hsa03060	1.86977095
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.82146543
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79822420
19	GABAergic synapse_Homo sapiens_hsa04727	1.72145457
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68919642
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.57805133
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.53394607
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51576329
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50753943
25	Circadian entrainment_Homo sapiens_hsa04713	1.50561688
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45495841
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.43683728
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39715154
29	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.37936100
30	Long-term depression_Homo sapiens_hsa04730	1.18280645
31	Fatty acid elongation_Homo sapiens_hsa00062	1.15802800
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14280670
33	Cholinergic synapse_Homo sapiens_hsa04725	1.12985500
34	Dopaminergic synapse_Homo sapiens_hsa04728	1.11454575
35	Oxidative phosphorylation_Homo sapiens_hsa00190	1.10638224
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.09977468
37	Olfactory transduction_Homo sapiens_hsa04740	1.09358281
38	Serotonergic synapse_Homo sapiens_hsa04726	1.08310697
39	Parkinsons disease_Homo sapiens_hsa05012	1.04423073
40	Axon guidance_Homo sapiens_hsa04360	1.04295633
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02701863
42	Cocaine addiction_Homo sapiens_hsa05030	0.99763099
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.99265200
44	Amphetamine addiction_Homo sapiens_hsa05031	0.97053214
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.96287651
46	Homologous recombination_Homo sapiens_hsa03440	0.94383298
47	Gastric acid secretion_Homo sapiens_hsa04971	0.94054071
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91030876
49	ABC transporters_Homo sapiens_hsa02010	0.89115692
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.87839915
51	Huntingtons disease_Homo sapiens_hsa05016	0.86107272
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.85850894
53	mRNA surveillance pathway_Homo sapiens_hsa03015	0.84648149
54	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.82656524
55	Proteasome_Homo sapiens_hsa03050	0.82063429
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.81711061
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81343542
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.81085700
59	RNA degradation_Homo sapiens_hsa03018	0.79157697
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.77814890
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75229900
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72708496
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71982464
64	Renin secretion_Homo sapiens_hsa04924	0.71221278
65	Insulin secretion_Homo sapiens_hsa04911	0.67304563
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.66733324
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63355916
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.59129268
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58134624
70	Lysine degradation_Homo sapiens_hsa00310	0.57135356
71	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.57075166
72	Mismatch repair_Homo sapiens_hsa03430	0.56805975
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56757574
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55106367
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.54808244
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.54390004
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53694706
78	Wnt signaling pathway_Homo sapiens_hsa04310	0.53573507
79	Cell cycle_Homo sapiens_hsa04110	0.52950010
80	Alzheimers disease_Homo sapiens_hsa05010	0.52347418
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52258195
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50284887
83	Oocyte meiosis_Homo sapiens_hsa04114	0.50247557
84	Salivary secretion_Homo sapiens_hsa04970	0.50120738
85	Caffeine metabolism_Homo sapiens_hsa00232	0.46824652
86	Folate biosynthesis_Homo sapiens_hsa00790	0.45465298
87	Retinol metabolism_Homo sapiens_hsa00830	0.44921973
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.44097948
89	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.40689901
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36949893
91	RNA transport_Homo sapiens_hsa03013	0.36450333
92	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36051298
93	Alcoholism_Homo sapiens_hsa05034	0.35402631
94	Metabolic pathways_Homo sapiens_hsa01100	0.35030145
95	Tight junction_Homo sapiens_hsa04530	0.34881959
96	Fatty acid degradation_Homo sapiens_hsa00071	0.34636270
97	Histidine metabolism_Homo sapiens_hsa00340	0.33689615
98	Melanogenesis_Homo sapiens_hsa04916	0.33222055
99	Colorectal cancer_Homo sapiens_hsa05210	0.33098554
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32271321

ADAM3B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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