ADAM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.72846456
2motile cilium assembly (GO:0044458)9.52192319
3reproduction (GO:0000003)9.47511902
4spermatid development (GO:0007286)9.30341989
5male meiosis (GO:0007140)8.75344227
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.72361415
7cilium movement (GO:0003341)8.71602842
8regulation of cilium movement (GO:0003352)8.13911290
9synaptonemal complex organization (GO:0070193)8.05118520
10synaptonemal complex assembly (GO:0007130)7.66700292
11single fertilization (GO:0007338)7.63813677
12sperm capacitation (GO:0048240)6.82557204
13fertilization (GO:0009566)6.50727710
14negative regulation of inclusion body assembly (GO:0090084)6.27202080
15DNA methylation involved in gamete generation (GO:0043046)6.18657082
16spermatogenesis (GO:0007283)6.04526918
17male gamete generation (GO:0048232)6.02369619
18male meiosis I (GO:0007141)5.79934762
19gamete generation (GO:0007276)5.53612024
20ventricular system development (GO:0021591)5.52676329
21microtubule depolymerization (GO:0007019)5.51361437
22chromosome organization involved in meiosis (GO:0070192)5.42559370
23germ cell development (GO:0007281)5.31641688
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.30008370
25organic cation transport (GO:0015695)5.23252527
26regulation of inclusion body assembly (GO:0090083)5.11415570
27meiotic nuclear division (GO:0007126)5.03539077
28calcium ion-dependent exocytosis (GO:0017156)4.87167427
29cell recognition (GO:0008037)4.86730442
30seminiferous tubule development (GO:0072520)4.84136742
31regulation of microtubule-based movement (GO:0060632)4.82135251
32meiosis I (GO:0007127)4.67800512
33microtubule severing (GO:0051013)4.45784427
34multicellular organismal reproductive process (GO:0048609)4.35619371
35meiotic cell cycle (GO:0051321)4.28361158
36left/right pattern formation (GO:0060972)4.25685091
37monoubiquitinated protein deubiquitination (GO:0035520)4.24248460
38spermatid nucleus differentiation (GO:0007289)4.22154949
39protein localization to cilium (GO:0061512)4.20654302
40genitalia morphogenesis (GO:0035112)3.96904643
41glycerol ether metabolic process (GO:0006662)3.96718701
42chaperone-mediated protein complex assembly (GO:0051131)3.84238082
43intraciliary transport (GO:0042073)3.68851401
44ether metabolic process (GO:0018904)3.66337833
45gene silencing by RNA (GO:0031047)3.65656941
46multicellular organismal development (GO:0007275)3.54189888
47protein polyglutamylation (GO:0018095)3.51801630
48lactate metabolic process (GO:0006089)3.47562196
49synapsis (GO:0007129)3.34832191
50axoneme assembly (GO:0035082)3.34464277
51microtubule-based movement (GO:0007018)3.31007523
52chromosome condensation (GO:0030261)3.29211444
53negative regulation of organelle assembly (GO:1902116)3.26841577
54meiotic cell cycle process (GO:1903046)3.21775674
55carnitine transport (GO:0015879)3.20116874
56amino-acid betaine transport (GO:0015838)3.20116874
57alditol metabolic process (GO:0019400)3.19586630
58carnitine transmembrane transport (GO:1902603)3.15471206
59DNA packaging (GO:0006323)3.15143230
60cilium organization (GO:0044782)3.14245378
61nucleoside diphosphate phosphorylation (GO:0006165)3.12910386
62protein refolding (GO:0042026)3.12341690
63polyol catabolic process (GO:0046174)3.11747049
64regulation of centriole replication (GO:0046599)3.09998783
65protein K11-linked deubiquitination (GO:0035871)3.05002949
66regulation of spindle checkpoint (GO:0090231)2.98499779
67cilium assembly (GO:0042384)2.98293805
68GTP biosynthetic process (GO:0006183)2.96125778
69glycolytic process (GO:0006096)2.95127785
70regulation of meiosis I (GO:0060631)2.93948292
71nuclear pore complex assembly (GO:0051292)2.93536105
72single strand break repair (GO:0000012)2.91920526
73cilium morphogenesis (GO:0060271)2.91276897
74cellular component assembly involved in morphogenesis (GO:0010927)2.91266455
75centriole assembly (GO:0098534)2.90295692
76mitotic sister chromatid cohesion (GO:0007064)2.89758155
77centriole replication (GO:0007099)2.85719964
78microtubule polymerization or depolymerization (GO:0031109)2.82443398
79regulation of protein polyubiquitination (GO:1902914)2.80798644
80glycerol metabolic process (GO:0006071)2.79275484
81nucleus organization (GO:0006997)2.74045838
82sexual reproduction (GO:0019953)2.69864763
83gene silencing (GO:0016458)2.66449763
84UTP biosynthetic process (GO:0006228)2.64654769
85negative regulation of DNA repair (GO:0045738)2.53392076
86peptidyl-glutamic acid modification (GO:0018200)2.49398386
87cilium or flagellum-dependent cell motility (GO:0001539)14.1869874
88fusion of sperm to egg plasma membrane (GO:0007342)14.0551115
89sperm motility (GO:0030317)12.7811798
90acrosome assembly (GO:0001675)11.5479302
91multicellular organism reproduction (GO:0032504)11.4112537
92sperm-egg recognition (GO:0035036)11.2754967
93axonemal dynein complex assembly (GO:0070286)10.9253096
94plasma membrane fusion (GO:0045026)10.7157500
95cell wall macromolecule metabolic process (GO:0044036)10.6676960
96cell wall macromolecule catabolic process (GO:0016998)10.6676960
97acrosome reaction (GO:0007340)10.5806323
98binding of sperm to zona pellucida (GO:0007339)10.3334175
99epithelial cilium movement (GO:0003351)10.1830315
100cell-cell recognition (GO:0009988)10.0897009

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.26066489
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.65051865
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.55524297
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76564377
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52934256
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.39240453
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31135833
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26951988
9ZNF274_21170338_ChIP-Seq_K562_Hela2.23166495
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15472773
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07702474
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04012967
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0343718
14VDR_22108803_ChIP-Seq_LS180_Human1.89402774
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85713273
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.81687383
17ELK4_26923725_Chip-Seq_MESODERM_Mouse1.75042723
18KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69840834
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69713880
20RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68768494
21STAT1_17558387_ChIP-Seq_HELA_Human1.61236628
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57785834
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.55033104
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.55013687
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53365197
26* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49800556
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.47022439
28TAL1_26923725_Chip-Seq_HPCs_Mouse1.46774977
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46069415
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45915472
31KDM2B_26808549_Chip-Seq_REH_Human1.43819020
32CBP_20019798_ChIP-Seq_JUKART_Human1.41487485
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41487485
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38030973
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36048762
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31070720
37GATA3_21867929_ChIP-Seq_CD8_Mouse1.30860980
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30310139
39* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29999756
40FLI1_21867929_ChIP-Seq_TH2_Mouse1.22881926
41LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21768586
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21325140
43REST_21632747_ChIP-Seq_MESCs_Mouse1.20919127
44GATA3_21867929_ChIP-Seq_TH1_Mouse1.18396987
45CRX_20693478_ChIP-Seq_RETINA_Mouse1.16851006
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14572140
47SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13945537
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.13733042
49P53_21459846_ChIP-Seq_SAOS-2_Human1.13323860
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11210109
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10652198
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10554075
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10554075
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09618677
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.08636845
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08634031
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08083383
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07986649
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07656924
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07633493
61RNF2_27304074_Chip-Seq_NSC_Mouse1.05986500
62GF1_26923725_Chip-Seq_HPCs_Mouse1.05724294
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.04313755
64P53_22387025_ChIP-Seq_ESCs_Mouse1.04265859
65RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04110382
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03699720
67RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02311307
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01448367
69P300_18555785_Chip-Seq_ESCs_Mouse1.00984452
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00605665
71* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00191072
72OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98745769
73TAF15_26573619_Chip-Seq_HEK293_Human0.98509501
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97778167
75CMYC_18555785_Chip-Seq_ESCs_Mouse0.97527112
76KLF4_18555785_Chip-Seq_ESCs_Mouse0.97212755
77ERG_20517297_ChIP-Seq_VCAP_Human0.95941282
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95638092
79ESET_19884257_ChIP-Seq_ESCs_Mouse0.93386954
80ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93151462
81SPI1_26923725_Chip-Seq_HPCs_Mouse0.92582284
82* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92509319
83STAT3_18555785_Chip-Seq_ESCs_Mouse0.91662237
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90912693
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90519959
86SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88655188
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88475836
88SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88109614
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.87838526
90CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86927100
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85878065
92PU1_27457419_Chip-Seq_LIVER_Mouse0.84712459
93SOX9_26525672_Chip-Seq_HEART_Mouse0.84595750
94NFYB_21822215_ChIP-Seq_K562_Human0.84224360
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.83942053
96FLI1_21867929_ChIP-Seq_CD8_Mouse0.83731687
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83172336
98MYC_27129775_Chip-Seq_CORNEA_Mouse0.83137173
99SOX2_21211035_ChIP-Seq_LN229_Human0.83062815
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82471359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08699736
2MP0001929_abnormal_gametogenesis5.58791234
3MP0008877_abnormal_DNA_methylation5.22829907
4MP0002210_abnormal_sex_determination3.78722488
5MP0002161_abnormal_fertility/fecundity3.30201948
6MP0002653_abnormal_ependyma_morphology3.17282453
7MP0001145_abnormal_male_reproductive3.17083676
8MP0000653_abnormal_sex_gland2.75110966
9MP0005623_abnormal_meninges_morphology2.09891454
10MP0005670_abnormal_white_adipose2.02026252
11MP0005410_abnormal_fertilization15.5786354
12MP0002160_abnormal_reproductive_system1.85919832
13MP0008057_abnormal_DNA_replication1.59581144
14MP0002282_abnormal_trachea_morphology1.51888941
15MP0003646_muscle_fatigue1.25537412
16MP0008058_abnormal_DNA_repair1.22782652
17MP0005647_abnormal_sex_gland1.21602852
18MP0009046_muscle_twitch1.10457989
19MP0004233_abnormal_muscle_weight1.10201499
20MP0001765_abnormal_ion_homeostasis1.10159539
21MP0008995_early_reproductive_senescence1.09888674
22MP0001984_abnormal_olfaction1.04160595
23MP0010094_abnormal_chromosome_stability1.02856248
24MP0003011_delayed_dark_adaptation0.94315723
25MP0005389_reproductive_system_phenotype0.94141517
26MP0003786_premature_aging0.81182700
27MP0000569_abnormal_digit_pigmentation0.78098623
28MP0008007_abnormal_cellular_replicative0.74872647
29MP0005377_hearing/vestibular/ear_phenot0.63794975
30MP0003878_abnormal_ear_physiology0.63794975
31MP0002234_abnormal_pharynx_morphology0.63463131
32MP0003950_abnormal_plasma_membrane0.61731337
33MP0003115_abnormal_respiratory_system0.61212978
34MP0000358_abnormal_cell_content/0.60775789
35MP0005636_abnormal_mineral_homeostasis0.55617556
36MP0005397_hematopoietic_system_phenotyp0.54348449
37MP0001545_abnormal_hematopoietic_system0.54348449
38MP0002928_abnormal_bile_duct0.53820399
39MP0004134_abnormal_chest_morphology0.52641412
40MP0003699_abnormal_female_reproductive0.48960652
41MP0003111_abnormal_nucleus_morphology0.47770215
42MP0004808_abnormal_hematopoietic_stem0.47393382
43MP0009278_abnormal_bone_marrow0.47001118
44MP0005666_abnormal_adipose_tissue0.44573108
45MP0001324_abnormal_eye_pigmentation0.44392162
46MP0003329_amyloid_beta_deposits0.43493830
47MP0004036_abnormal_muscle_relaxation0.43010592
48MP0001293_anophthalmia0.42919823
49MP0010307_abnormal_tumor_latency0.42730828
50MP0005253_abnormal_eye_physiology0.41808362
51MP0001119_abnormal_female_reproductive0.41585976
52MP0005551_abnormal_eye_electrophysiolog0.41266355
53MP0002102_abnormal_ear_morphology0.37436097
54MP0004019_abnormal_vitamin_homeostasis0.36126951
55MP0001764_abnormal_homeostasis0.36108929
56MP0005391_vision/eye_phenotype0.35089239
57MP0002971_abnormal_brown_adipose0.34312695
58MP0002269_muscular_atrophy0.34244956
59MP0001730_embryonic_growth_arrest0.33089798
60MP0001727_abnormal_embryo_implantation0.31261890
61MP0009115_abnormal_fat_cell0.29291774
62MP0006036_abnormal_mitochondrial_physio0.27578550
63MP0003633_abnormal_nervous_system0.25730812
64MP0000313_abnormal_cell_death0.25183544
65MP0003861_abnormal_nervous_system0.25048786
66MP0004133_heterotaxia0.23093049
67MP0002152_abnormal_brain_morphology0.22872253
68MP0003077_abnormal_cell_cycle0.22401613
69MP0004811_abnormal_neuron_physiology0.21593690
70MP0002092_abnormal_eye_morphology0.21344096
71MP0003045_fibrosis0.21296067
72MP0008961_abnormal_basal_metabolism0.20603558
73MP0003879_abnormal_hair_cell0.20463056
74MP0002084_abnormal_developmental_patter0.20299268
75MP0000604_amyloidosis0.19543472
76MP0001661_extended_life_span0.19528863
77MP0000534_abnormal_ureter_morphology0.19264035
78MP0001851_eye_inflammation0.19192805
79MP0003942_abnormal_urinary_system0.18698149
80MP0003631_nervous_system_phenotype0.18525908
81MP0000427_abnormal_hair_cycle0.18426939
82MP0000751_myopathy0.18212783
83MP0006072_abnormal_retinal_apoptosis0.18060629
84MP0002139_abnormal_hepatobiliary_system0.16264735
85MP0006035_abnormal_mitochondrial_morpho0.15555912
86MP0005423_abnormal_somatic_nervous0.14968319
87MP0002229_neurodegeneration0.14422152
88MP0002169_no_abnormal_phenotype0.14380399
89MP0002108_abnormal_muscle_morphology0.14280501
90MP0003948_abnormal_gas_homeostasis0.14275638
91MP0001986_abnormal_taste_sensitivity0.14251385
92MP0002295_abnormal_pulmonary_circulatio0.14233015
93MP0002873_normal_phenotype0.14118920
94MP0002736_abnormal_nociception_after0.13867321
95MP0002405_respiratory_system_inflammati0.13682520
96MP0001849_ear_inflammation0.13659034
97MP0001672_abnormal_embryogenesis/_devel0.13305504
98MP0005380_embryogenesis_phenotype0.13305504
99MP0001697_abnormal_embryo_size0.12657704
100MP0002970_abnormal_white_adipose0.12606663

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.54393228
2Abnormal respiratory motile cilium morphology (HP:0005938)9.16133988
3Abnormal respiratory epithelium morphology (HP:0012253)9.16133988
4Rhinitis (HP:0012384)7.93296794
5Abnormal ciliary motility (HP:0012262)7.78557437
6Chronic bronchitis (HP:0004469)7.40845553
7Nasal polyposis (HP:0100582)6.42176348
8Infertility (HP:0000789)6.37803098
9Abnormality of the nasal mucosa (HP:0000433)5.28121507
10Bronchiectasis (HP:0002110)4.60366739
11Bronchitis (HP:0012387)4.54843446
12Nephronophthisis (HP:0000090)4.43057003
13Male infertility (HP:0003251)3.70097678
14Recurrent sinusitis (HP:0011108)3.52848755
15Abnormality of the renal medulla (HP:0100957)3.38907980
16Recurrent otitis media (HP:0000403)3.31962155
17Abnormality of the lower motor neuron (HP:0002366)3.26858071
18Tubulointerstitial nephritis (HP:0001970)3.01656450
19Abnormal spermatogenesis (HP:0008669)3.01554331
20Gonadotropin excess (HP:0000837)2.89843817
21Recurrent bronchitis (HP:0002837)2.64175376
22Abnormality of midbrain morphology (HP:0002418)2.62846055
23Molar tooth sign on MRI (HP:0002419)2.62846055
24Medial flaring of the eyebrow (HP:0010747)2.62712852
25Amyotrophic lateral sclerosis (HP:0007354)2.58429433
26Tubular atrophy (HP:0000092)2.55626766
27Tubulointerstitial abnormality (HP:0001969)2.46673620
28Fibular hypoplasia (HP:0003038)2.38299844
29Impulsivity (HP:0100710)2.24512350
30Azoospermia (HP:0000027)2.13110241
31Postaxial foot polydactyly (HP:0001830)2.07357880
32Impaired proprioception (HP:0010831)2.00684105
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5522789
34Absent/shortened dynein arms (HP:0200106)13.1373095
35Dynein arm defect of respiratory motile cilia (HP:0012255)13.1373095
36Stage 5 chronic kidney disease (HP:0003774)1.96561156
37Tubulointerstitial fibrosis (HP:0005576)1.89654390
38Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88516444
39Congenital hepatic fibrosis (HP:0002612)1.85953139
40Abnormality of the renal cortex (HP:0011035)1.83503230
41Upper motor neuron abnormality (HP:0002127)1.83065266
42Absent frontal sinuses (HP:0002688)1.79956655
43Short ribs (HP:0000773)1.77066840
44Abnormality of the dental root (HP:0006486)1.75925870
45Taurodontia (HP:0000679)1.75925870
46Abnormality of permanent molar morphology (HP:0011071)1.75925870
47Oculomotor apraxia (HP:0000657)1.75493993
48Abnormality of dentin (HP:0010299)1.74028112
49Polydipsia (HP:0001959)1.73919749
50Abnormal drinking behavior (HP:0030082)1.73919749
51Degeneration of anterior horn cells (HP:0002398)1.73688346
52Abnormality of the anterior horn cell (HP:0006802)1.73688346
53J-shaped sella turcica (HP:0002680)1.73233720
54Chronic sinusitis (HP:0011109)1.71476332
55Spastic tetraparesis (HP:0001285)1.68110312
56Microglossia (HP:0000171)1.67796129
57Abnormal gallbladder physiology (HP:0012438)1.64960528
58Cholecystitis (HP:0001082)1.64960528
59Supernumerary spleens (HP:0009799)1.64090705
60Abnormality of molar morphology (HP:0011070)1.64014572
61Abnormality of molar (HP:0011077)1.64014572
62Renal dysplasia (HP:0000110)1.63313292
63Abnormality of the dental pulp (HP:0006479)1.59799245
64Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59473687
65Postaxial hand polydactyly (HP:0001162)1.59206462
66Heterotopia (HP:0002282)1.58889300
67Facial cleft (HP:0002006)1.57691055
68Abnormality of renal excretion (HP:0011036)1.55318793
69Bell-shaped thorax (HP:0001591)1.51785443
70Congenital primary aphakia (HP:0007707)1.50866675
71Gait imbalance (HP:0002141)1.49762451
72Aplasia/Hypoplasia of the fibula (HP:0006492)1.48870167
73Absent epiphyses (HP:0010577)1.48293948
74Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.48293948
75Dyschromatopsia (HP:0007641)1.45730076
76Cystic liver disease (HP:0006706)1.44077996
77Deformed sella turcica (HP:0002681)1.41825956
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.41782912
7911 pairs of ribs (HP:0000878)1.39643821
80Abnormal biliary tract physiology (HP:0012439)1.39186860
81Bile duct proliferation (HP:0001408)1.39186860
82Median cleft lip (HP:0000161)1.38736066
83Short thorax (HP:0010306)1.37387501
84Pancreatic fibrosis (HP:0100732)1.36112097
85Broad distal phalanx of finger (HP:0009836)1.32581276
86Aplasia/Hypoplasia of the lens (HP:0008063)1.30579980
87Abnormality of ocular smooth pursuit (HP:0000617)1.28870419
88Breast carcinoma (HP:0003002)1.28775909
89Decreased central vision (HP:0007663)1.28262960
90Nephropathy (HP:0000112)1.27772797
91Nephrogenic diabetes insipidus (HP:0009806)1.27648259
92Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.25664843
93Pachygyria (HP:0001302)1.19824494
94Abnormal urine output (HP:0012590)1.19820974
95True hermaphroditism (HP:0010459)1.16883730
96Conjunctival telangiectasia (HP:0000524)1.16545559
97Hypoplasia of dental enamel (HP:0006297)1.15317187
98Asymmetric septal hypertrophy (HP:0001670)1.15183928
99Choroideremia (HP:0001139)1.14849334
100Decreased motor nerve conduction velocity (HP:0003431)1.14578321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.30038434
2PDK39.30038434
3PDK26.04025935
4TESK14.33664489
5PRKD33.80141878
6ICK3.22503500
7PNCK2.41434757
8PTK2B2.35270775
9WNK42.23438451
10STK392.13177513
11NEK21.73289684
12STK381.25286076
13MAPK151.08043174
14DYRK1B1.04505003
15WNK10.97984099
16PDK10.91712936
17TYRO30.90628332
18PASK0.85609128
19CCNB10.81757464
20STK30.80397122
21DYRK30.74939692
22CDC70.73159611
23IRAK10.65789868
24TTK0.62087468
25WEE10.59006794
26CAMK1G0.58134935
27LMTK20.56211027
28PINK10.50643075
29CHEK20.48623976
30CHEK10.47204189
31TESK20.43597963
32ATR0.43441030
33PLK40.40992741
34MAP2K60.40252730
35ATM0.33017267
36PDPK10.32949954
37EEF2K0.29814486
38STK38L0.29502391
39PAK10.29203366
40MTOR0.27640112
41NTRK20.27541915
42PAK20.25034463
43CDK120.24438453
44MUSK0.23541471
45CAMKK10.22306286
46PLK10.21745671
47BMPR1B0.21049417
48IRAK20.20732975
49PRKCG0.20728687
50RIPK40.19512388
51PRKAA10.17866884
52MAPKAPK50.16815997
53RPS6KB10.15658490
54NEK60.14548696
55BRSK20.13326915
56MARK20.12295534
57WNK30.10462353
58CSNK1D0.07501768
59MAP3K100.05620292
60PRKCZ0.05256657
61CSNK2A10.05253308
62CDK10.04898852
63PRKG10.04864328
64PRKCQ0.04362927
65CDK20.03931660
66GSK3B0.03912138
67PRKACG0.03823196
68BRAF0.03618541
69CDK150.03498681
70MARK30.03481042
71PAK40.03467548
72MAP3K40.02900858
73MAPK80.02345525
74PRKDC0.02278004
75ZAP700.02072815
76PRKACB0.01616433
77CDK30.01497142
78CDK180.01448661
79CSNK2A20.01322989
80CDK11A0.00533223
81RPS6KA10.00471539
82PRKG20.00075327
83PKN1-0.0412459
84PRKCA-0.0355035
85MAPK1-0.0335662
86CDK4-0.0299947
87CAMK2A-0.0291244
88CDK6-0.0281082
89MAPK10-0.0254896
90RIPK1-0.0180386
91RPS6KA3-0.0136569
92CDK14-0.0112094
93CSF1R-0.0091093
94STK11-0.0087732
95PRKCB-0.0087597
96EGFR-0.0076886
97PAK6-0.0053946
98BRSK1-0.0040735
99PDGFRB-0.0037589
100STK10-0.0036089

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.99932425
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.45477320
3Pyruvate metabolism_Homo sapiens_hsa006204.39129581
4Propanoate metabolism_Homo sapiens_hsa006403.45483449
5Fatty acid biosynthesis_Homo sapiens_hsa000613.29977422
6Glucagon signaling pathway_Homo sapiens_hsa049222.90209398
7Basal transcription factors_Homo sapiens_hsa030222.63170701
8Selenocompound metabolism_Homo sapiens_hsa004502.50727767
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41184983
10Pentose phosphate pathway_Homo sapiens_hsa000302.36537275
11Dorso-ventral axis formation_Homo sapiens_hsa043202.33549388
12Linoleic acid metabolism_Homo sapiens_hsa005912.31738268
13Fanconi anemia pathway_Homo sapiens_hsa034602.16274861
14Oocyte meiosis_Homo sapiens_hsa041142.03071260
15Glycerolipid metabolism_Homo sapiens_hsa005611.95710581
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90577942
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.81734938
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79914854
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.77092925
20Huntingtons disease_Homo sapiens_hsa050161.68541451
21PPAR signaling pathway_Homo sapiens_hsa033201.66358082
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.64721698
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55743406
24Amphetamine addiction_Homo sapiens_hsa050311.54715563
25Carbon metabolism_Homo sapiens_hsa012001.45257027
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42039606
27Fructose and mannose metabolism_Homo sapiens_hsa000511.41096992
28Renin secretion_Homo sapiens_hsa049241.32110581
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.30743661
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30170055
31mRNA surveillance pathway_Homo sapiens_hsa030151.29417768
32RNA transport_Homo sapiens_hsa030131.21500219
33Cardiac muscle contraction_Homo sapiens_hsa042601.21434280
34Antigen processing and presentation_Homo sapiens_hsa046121.20386227
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15446273
36Mineral absorption_Homo sapiens_hsa049781.03403367
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03087823
38Fat digestion and absorption_Homo sapiens_hsa049751.02165860
39Ether lipid metabolism_Homo sapiens_hsa005651.00782157
40Fatty acid metabolism_Homo sapiens_hsa012121.00521624
41Purine metabolism_Homo sapiens_hsa002301.00141382
42Biosynthesis of amino acids_Homo sapiens_hsa012300.96805679
43Fatty acid degradation_Homo sapiens_hsa000710.94795278
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94348420
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90361425
46Long-term potentiation_Homo sapiens_hsa047200.82026464
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80402447
48ABC transporters_Homo sapiens_hsa020100.76834778
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74197299
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69527480
51Estrogen signaling pathway_Homo sapiens_hsa049150.69223459
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.68333672
53Glutathione metabolism_Homo sapiens_hsa004800.67985199
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67546373
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64354839
56Chemical carcinogenesis_Homo sapiens_hsa052040.61845035
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59877701
58Calcium signaling pathway_Homo sapiens_hsa040200.59489657
59Collecting duct acid secretion_Homo sapiens_hsa049660.56468636
60Legionellosis_Homo sapiens_hsa051340.52992817
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.51532611
62N-Glycan biosynthesis_Homo sapiens_hsa005100.50359859
63Arachidonic acid metabolism_Homo sapiens_hsa005900.49902658
64Insulin secretion_Homo sapiens_hsa049110.49246153
65VEGF signaling pathway_Homo sapiens_hsa043700.49057780
66Hedgehog signaling pathway_Homo sapiens_hsa043400.48458571
67Thyroid hormone synthesis_Homo sapiens_hsa049180.46234669
68Bile secretion_Homo sapiens_hsa049760.45869980
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45405485
70Inositol phosphate metabolism_Homo sapiens_hsa005620.45108920
71AMPK signaling pathway_Homo sapiens_hsa041520.43067540
72Renin-angiotensin system_Homo sapiens_hsa046140.40975492
73Endocytosis_Homo sapiens_hsa041440.39420553
74Taste transduction_Homo sapiens_hsa047420.36191652
75Metabolic pathways_Homo sapiens_hsa011000.36152561
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34452659
77Systemic lupus erythematosus_Homo sapiens_hsa053220.32071625
78Protein digestion and absorption_Homo sapiens_hsa049740.30920716
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29384161
80Synaptic vesicle cycle_Homo sapiens_hsa047210.27664311
81Pancreatic secretion_Homo sapiens_hsa049720.27142433
82Circadian entrainment_Homo sapiens_hsa047130.26464754
83RNA degradation_Homo sapiens_hsa030180.26218010
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24968474
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.24530839
86Pyrimidine metabolism_Homo sapiens_hsa002400.24464926
87Salivary secretion_Homo sapiens_hsa049700.23783442
88Homologous recombination_Homo sapiens_hsa034400.22332584
89B cell receptor signaling pathway_Homo sapiens_hsa046620.22294235
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21638556
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21632084
92Gastric acid secretion_Homo sapiens_hsa049710.20949834
93cAMP signaling pathway_Homo sapiens_hsa040240.20070224
94Wnt signaling pathway_Homo sapiens_hsa043100.19169250
95Cell cycle_Homo sapiens_hsa041100.18325314
96Retinol metabolism_Homo sapiens_hsa008300.14235509
97Viral carcinogenesis_Homo sapiens_hsa052030.10961700
98Sulfur metabolism_Homo sapiens_hsa009200.09288594
99Glutamatergic synapse_Homo sapiens_hsa047240.07550489
100Cocaine addiction_Homo sapiens_hsa050300.07164586

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