ADAM9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.11358764
2apoptotic cell clearance (GO:0043277)4.15993454
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.12829873
4* cell adhesion mediated by integrin (GO:0033627)3.98489724
5dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.95329818
6protein retention in ER lumen (GO:0006621)3.93347590
7cell-substrate junction assembly (GO:0007044)3.77252011
8barbed-end actin filament capping (GO:0051016)3.76145931
9low-density lipoprotein particle clearance (GO:0034383)3.73966454
10mesodermal cell differentiation (GO:0048333)3.66422549
11hypotonic response (GO:0006971)3.64129082
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62206624
13collagen fibril organization (GO:0030199)3.52873588
14protein hydroxylation (GO:0018126)3.48230979
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.37781484
16negative regulation of fibrinolysis (GO:0051918)3.35422839
17endodermal cell differentiation (GO:0035987)3.35065247
18COPII vesicle coating (GO:0048208)3.30901096
19skin morphogenesis (GO:0043589)3.27130538
20negative regulation of anoikis (GO:2000811)3.18856048
21chondrocyte proliferation (GO:0035988)3.18671079
22negative regulation of chondrocyte differentiation (GO:0032331)3.16609670
23protein localization to endosome (GO:0036010)3.15732266
24desmosome organization (GO:0002934)3.13689521
25negative regulation of fatty acid transport (GO:2000192)3.10354215
26alpha-linolenic acid metabolic process (GO:0036109)3.10233603
27protein carboxylation (GO:0018214)3.08528763
28peptidyl-glutamic acid carboxylation (GO:0017187)3.08528763
29regulation of transforming growth factor beta2 production (GO:0032909)3.07048834
30vesicle coating (GO:0006901)3.02619889
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02085406
32retina vasculature morphogenesis in camera-type eye (GO:0061299)2.97483403
33type B pancreatic cell proliferation (GO:0044342)2.94768600
34epoxygenase P450 pathway (GO:0019373)2.94608556
35regulation of early endosome to late endosome transport (GO:2000641)2.93397215
36positive regulation of blood vessel endothelial cell migration (GO:0043536)2.90317055
37protein heterotrimerization (GO:0070208)2.89969369
38plasma lipoprotein particle clearance (GO:0034381)2.88219247
39positive regulation of p38MAPK cascade (GO:1900745)2.87986080
40wound healing, spreading of epidermal cells (GO:0035313)2.87845328
41plasma membrane repair (GO:0001778)2.86357415
42positive regulation of extracellular matrix organization (GO:1903055)2.84442425
43regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.82809546
44heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.79858863
45hyaluronan catabolic process (GO:0030214)2.79263393
46positive regulation of hemostasis (GO:1900048)2.78718419
47positive regulation of blood coagulation (GO:0030194)2.78718419
48basement membrane organization (GO:0071711)2.74327832
49positive regulation of receptor recycling (GO:0001921)2.72802937
50fibrinolysis (GO:0042730)2.72687030
51cellular copper ion homeostasis (GO:0006878)2.71733492
52regulation of cholesterol storage (GO:0010885)2.71254514
53adherens junction assembly (GO:0034333)2.70189917
54neuron projection extension involved in neuron projection guidance (GO:1902284)2.69754068
55axon extension involved in axon guidance (GO:0048846)2.69754068
56cellular response to vitamin (GO:0071295)2.68124436
57muscle cell migration (GO:0014812)2.66890613
58extracellular matrix assembly (GO:0085029)2.66784671
59regulation of fibrinolysis (GO:0051917)2.65357517
60negative regulation of smooth muscle cell migration (GO:0014912)2.63595978
61positive regulation of osteoblast proliferation (GO:0033690)2.63463664
62positive regulation of fatty acid beta-oxidation (GO:0032000)2.62662931
63renal filtration (GO:0097205)2.62157084
64extracellular fibril organization (GO:0043206)2.59609962
65kidney mesenchyme development (GO:0072074)2.59274794
66focal adhesion assembly (GO:0048041)2.58445382
67cell-substrate adherens junction assembly (GO:0007045)2.58445382
68regulation of plasminogen activation (GO:0010755)2.57819133
69* collagen metabolic process (GO:0032963)2.57340656
70positive regulation of endothelial cell apoptotic process (GO:2000353)2.56746326
71positive regulation of coagulation (GO:0050820)2.56530767
72* extracellular matrix organization (GO:0030198)2.56354132
73regulation of anoikis (GO:2000209)2.56272684
74* regulation of membrane protein ectodomain proteolysis (GO:0051043)2.56232769
75L-phenylalanine catabolic process (GO:0006559)2.55507999
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55507999
77* extracellular structure organization (GO:0043062)2.55269231
78vascular endothelial growth factor signaling pathway (GO:0038084)2.54801568
79* positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.54685765
80regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.54603547
81negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.53350276
82* membrane protein ectodomain proteolysis (GO:0006509)2.53051739
83regulation of transforming growth factor beta1 production (GO:0032908)2.52835663
84wound healing, spreading of cells (GO:0044319)2.52327115
85glial cell migration (GO:0008347)2.52182147
86negative regulation of protein localization to plasma membrane (GO:1903077)2.51797515
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51170064
88complement activation, alternative pathway (GO:0006957)2.51048198
89cellular response to interferon-alpha (GO:0035457)2.50327373
90* collagen catabolic process (GO:0030574)2.49055784
91vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48364033
92virion attachment to host cell (GO:0019062)2.47931654
93adhesion of symbiont to host cell (GO:0044650)2.47931654
94mammary gland epithelial cell proliferation (GO:0033598)2.47382009
954-hydroxyproline metabolic process (GO:0019471)2.47367992
96actin filament depolymerization (GO:0030042)2.46536384
97regulation of protein activation cascade (GO:2000257)2.46515975
98* multicellular organismal macromolecule metabolic process (GO:0044259)2.46220545
99regulation of complement activation (GO:0030449)2.46141318
100stress fiber assembly (GO:0043149)2.46022308
101regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.44308141
102regulation of metalloenzyme activity (GO:0048552)2.43702307
103regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.42941597
104chondrocyte development (GO:0002063)2.41920989
105L-phenylalanine metabolic process (GO:0006558)2.41602579
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.41602579
107keratan sulfate catabolic process (GO:0042340)2.41165301
108* extracellular matrix disassembly (GO:0022617)2.40242952
109sulfur amino acid catabolic process (GO:0000098)2.39974126
110endothelial cell morphogenesis (GO:0001886)2.39964149
111negative regulation of stem cell proliferation (GO:2000647)2.39950570
112adhesion of symbiont to host (GO:0044406)2.39573057
113cell migration involved in sprouting angiogenesis (GO:0002042)2.38599291
114hippo signaling (GO:0035329)2.37948834
115wound healing (GO:0042060)2.37849737
116glomerular basement membrane development (GO:0032836)2.37794887
117* multicellular organismal metabolic process (GO:0044236)2.37231359
118pinocytosis (GO:0006907)2.37103336
119regulation of fatty acid beta-oxidation (GO:0031998)2.36884176
120fibril organization (GO:0097435)2.36422188
121cortical actin cytoskeleton organization (GO:0030866)2.35557763
122membrane raft organization (GO:0031579)2.33810069
123* multicellular organismal catabolic process (GO:0044243)2.33233593
124negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.30927261
125fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.30204857
126growth hormone receptor signaling pathway (GO:0060396)2.30108263
127glomerular visceral epithelial cell development (GO:0072015)2.30085013
128platelet-derived growth factor receptor signaling pathway (GO:0048008)2.29827322
129response to lipoprotein particle (GO:0055094)2.29227286
130COPI coating of Golgi vesicle (GO:0048205)2.27535562
131Golgi transport vesicle coating (GO:0048200)2.27535562
132epithelial cell-cell adhesion (GO:0090136)2.26525861
133glomerular filtration (GO:0003094)2.26506817
134platelet degranulation (GO:0002576)2.26037534
135cellular response to vitamin D (GO:0071305)2.25832318
136regulation of cholesterol homeostasis (GO:2000188)2.25525280
137mesenchymal-epithelial cell signaling (GO:0060638)2.23742468
138positive regulation of fatty acid oxidation (GO:0046321)2.21565648
139regulation of integrin-mediated signaling pathway (GO:2001044)2.21275599
140cysteine metabolic process (GO:0006534)2.21240806
141iron ion import (GO:0097286)2.20237794
142protein localization to cell surface (GO:0034394)2.20218401
143triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.19294726
144peptidyl-proline hydroxylation (GO:0019511)2.18998312
145lipoprotein metabolic process (GO:0042157)2.18819189
146substrate adhesion-dependent cell spreading (GO:0034446)2.16547959
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.15677493
148mannose metabolic process (GO:0006013)2.15219592
149semaphorin-plexin signaling pathway (GO:0071526)2.14041657
150endocardial cushion development (GO:0003197)2.13691839
151regulation of macrophage cytokine production (GO:0010935)2.12900046
152sequestering of extracellular ligand from receptor (GO:0035581)2.12482682
153substrate-dependent cell migration (GO:0006929)2.11787723
154positive regulation of lipid catabolic process (GO:0050996)2.11732870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.33467792
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.97958421
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.54324482
4CLOCK_20551151_ChIP-Seq_293T_Human3.14893493
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.13452239
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.98763900
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.94296659
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.77029338
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62304481
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.53087965
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36777302
12AR_21909140_ChIP-Seq_LNCAP_Human2.27246079
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14690948
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.13743786
15NRF2_20460467_ChIP-Seq_MEFs_Mouse2.13743786
16* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11203292
17ZNF263_19887448_ChIP-Seq_K562_Human2.09421230
18* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.08644248
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05551116
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.04771271
21* CJUN_26792858_Chip-Seq_BT549_Human2.01809170
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.01521091
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96247926
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.95398704
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.94296049
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.91362596
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.87083880
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85464405
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.85059444
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.80942600
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.79931157
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75685181
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75381047
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74240459
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.72354427
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69067102
37SOX2_20726797_ChIP-Seq_SW620_Human1.60749498
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59442685
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56926825
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.54513033
41EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.51340727
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51144751
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48736880
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42310555
45* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41240843
46* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41240843
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40525778
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39897076
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37876499
50BRD4_25478319_ChIP-Seq_HGPS_Human1.36332099
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.35434802
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33519627
53* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.33367888
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.33202679
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32176917
56TP53_22127205_ChIP-Seq_IMR90_Human1.31598104
57* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31578645
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29897859
59* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25946968
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25362047
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25294901
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24779308
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24665250
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24416617
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23690228
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23166009
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22984853
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21772220
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20814447
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.20671828
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.20671828
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.20284076
73TP53_16413492_ChIP-PET_HCT116_Human1.18719046
74* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16580102
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15758296
76TP53_18474530_ChIP-ChIP_U2OS_Human1.15293508
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.14645683
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14249175
79* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13164720
80* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.11299935
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09949311
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.09838221
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09327990
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08340525
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.05669994
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04440024
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02418411
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.02026594
89VDR_24787735_ChIP-Seq_THP-1_Human1.00949795
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00470011
91TP63_23658742_ChIP-Seq_EP156T_Human1.00300119
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00150263
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.98589683
94* ATF3_27146783_Chip-Seq_COLON_Human0.97450151
95RACK7_27058665_Chip-Seq_MCF-7_Human0.97395290
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96949688
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95942775
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95257566
99TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95203495
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95074405
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95024676
102CDX2_20551321_ChIP-Seq_CACO-2_Human0.94905442
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94805001
104* GATA4_25053715_ChIP-Seq_YYC3_Human0.94492343
105AHR_22903824_ChIP-Seq_MCF-7_Human0.93868559
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93483879
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93185593
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91120464
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90540735
110RXR_22108803_ChIP-Seq_LS180_Human0.90174687
111SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89491212
112* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88383808
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88213722
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87996354
115TP53_23651856_ChIP-Seq_MEFs_Mouse0.86228385
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86141190
117* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86123444
118GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85666563
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85185827
120PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84651421
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82716116
122* SOX17_20123909_ChIP-Seq_XEN_Mouse0.82588380
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80651943
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.80534285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.59264569
2MP0003705_abnormal_hypodermis_morpholog4.26386969
3MP0005275_abnormal_skin_tensile3.73629887
4MP0001958_emphysema2.79865166
5MP0005503_abnormal_tendon_morphology2.67645709
6MP0003279_aneurysm2.40870222
7MP0005623_abnormal_meninges_morphology2.40291327
8MP0004272_abnormal_basement_membrane2.37556837
9MP0002139_abnormal_hepatobiliary_system2.31385615
10MP0005058_abnormal_lysosome_morphology2.19308169
11MP0003566_abnormal_cell_adhesion2.16746318
12MP0009384_cardiac_valve_regurgitation2.15204529
13MP0005360_urolithiasis2.05956122
14MP0003941_abnormal_skin_development2.05954001
15MP0003300_gastrointestinal_ulcer1.89228727
16MP0003091_abnormal_cell_migration1.82656355
17MP0002295_abnormal_pulmonary_circulatio1.80370249
18MP0010352_gastrointestinal_tract_polyps1.73522285
19MP0009840_abnormal_foam_cell1.72272680
20MP0005023_abnormal_wound_healing1.67070961
21MP0003252_abnormal_bile_duct1.64815671
22MP0005257_abnormal_intraocular_pressure1.60659654
23MP0003195_calcinosis1.55088098
24MP0001849_ear_inflammation1.53506893
25MP0003950_abnormal_plasma_membrane1.53135101
26MP0006054_spinal_hemorrhage1.49716556
27MP0002060_abnormal_skin_morphology1.49525483
28MP0005083_abnormal_biliary_tract1.48117446
29MP0002877_abnormal_melanocyte_morpholog1.45942713
30MP0005365_abnormal_bile_salt1.40642293
31MP0004233_abnormal_muscle_weight1.39272058
32MP0003191_abnormal_cellular_cholesterol1.37919314
33MP0004858_abnormal_nervous_system1.36475714
34MP0000733_abnormal_muscle_development1.36257795
35MP0005085_abnormal_gallbladder_physiolo1.35144741
36MP0010368_abnormal_lymphatic_system1.34902534
37MP0003045_fibrosis1.33998989
38MP0002896_abnormal_bone_mineralization1.30320320
39MP0002168_other_aberrant_phenotype1.29671596
40MP0000604_amyloidosis1.28074275
41MP0000762_abnormal_tongue_morphology1.27285445
42MP0003690_abnormal_glial_cell1.25395102
43MP0001299_abnormal_eye_distance/1.22236111
44MP0000767_abnormal_smooth_muscle1.21968411
45MP0010234_abnormal_vibrissa_follicle1.21379780
46MP0004130_abnormal_muscle_cell1.21367424
47MP0000013_abnormal_adipose_tissue1.16406825
48MP0000537_abnormal_urethra_morphology1.16399804
49MP0001533_abnormal_skeleton_physiology1.14927194
50MP0005164_abnormal_response_to1.14320363
51MP0008875_abnormal_xenobiotic_pharmacok1.13243659
52MP0000858_altered_metastatic_potential1.12687498
53MP0004185_abnormal_adipocyte_glucose1.12464109
54MP0005508_abnormal_skeleton_morphology1.11616728
55MP0000534_abnormal_ureter_morphology1.10376016
56MP0010329_abnormal_lipoprotein_level1.09662744
57MP0005451_abnormal_body_composition1.06394416
58MP0001243_abnormal_dermal_layer1.03857250
59MP0003806_abnormal_nucleotide_metabolis1.03286099
60MP0002998_abnormal_bone_remodeling1.03066698
61MP0003172_abnormal_lysosome_physiology1.01976366
62MP0005666_abnormal_adipose_tissue1.01891807
63MP0005409_darkened_coat_color1.01617992
64MP0005165_increased_susceptibility_to1.01502750
65MP0003303_peritoneal_inflammation0.99539180
66MP0000343_altered_response_to0.99241904
67MP0005332_abnormal_amino_acid0.97576699
68MP0005197_abnormal_uvea_morphology0.96622964
69MP0005375_adipose_tissue_phenotype0.95291908
70MP0002108_abnormal_muscle_morphology0.93849130
71MP0001542_abnormal_bone_strength0.93486109
72MP0003828_pulmonary_edema0.92564430
73MP0000920_abnormal_myelination0.92309594
74MP0003075_altered_response_to0.91341408
75MP0000003_abnormal_adipose_tissue0.91249984
76MP0005390_skeleton_phenotype0.89714995
77MP0002118_abnormal_lipid_homeostasis0.88831383
78MP0004084_abnormal_cardiac_muscle0.88587709
79MP0003385_abnormal_body_wall0.87956389
80MP0001879_abnormal_lymphatic_vessel0.87658408
81MP0001216_abnormal_epidermal_layer0.87016397
82MP0005248_abnormal_Harderian_gland0.85922553
83MP0006082_CNS_inflammation0.85783210
84MP0000428_abnormal_craniofacial_morphol0.85568977
85MP0010030_abnormal_orbit_morphology0.85091288
86MP0009780_abnormal_chondrocyte_physiolo0.85072852
87MP0005193_abnormal_anterior_eye0.85006746
88MP0002090_abnormal_vision0.84761148
89MP0003329_amyloid_beta_deposits0.84659499
90MP0009053_abnormal_anal_canal0.83789428
91MP0000750_abnormal_muscle_regeneration0.82242516
92MP0000467_abnormal_esophagus_morphology0.82088452
93MP0000747_muscle_weakness0.81922413
94MP0003436_decreased_susceptibility_to0.81777356
95MP0010678_abnormal_skin_adnexa0.81256602
96MP0005408_hypopigmentation0.80309092
97MP0000609_abnormal_liver_physiology0.80139919
98MP0000569_abnormal_digit_pigmentation0.79861698
99MP0004087_abnormal_muscle_fiber0.79626417
100MP0005621_abnormal_cell_physiology0.79606284
101MP0003453_abnormal_keratinocyte_physiol0.79412254
102MP0000249_abnormal_blood_vessel0.78541977
103MP0002128_abnormal_blood_circulation0.76819673
104MP0003448_altered_tumor_morphology0.74913341
105MP0000627_abnormal_mammary_gland0.74061178
106MP0005076_abnormal_cell_differentiation0.73332778
107MP0004883_abnormal_blood_vessel0.72449353
108MP0003634_abnormal_glial_cell0.72228683
109MP0005501_abnormal_skin_physiology0.71658092
110MP0002933_joint_inflammation0.71530127
111MP0001666_abnormal_nutrient_absorption0.71337427
112MP0009643_abnormal_urine_homeostasis0.71297191
113MP0010386_abnormal_urinary_bladder0.70666206
114MP0000751_myopathy0.70504027
115MP0005595_abnormal_vascular_smooth0.70234645
116MP0005319_abnormal_enzyme/_coenzyme0.70225593
117MP0001614_abnormal_blood_vessel0.70110140
118MP0001348_abnormal_lacrimal_gland0.70096870
119MP0000749_muscle_degeneration0.70053778
120MP0002133_abnormal_respiratory_system0.69711712
121MP0005388_respiratory_system_phenotype0.69711712
122MP0002115_abnormal_skeleton_extremities0.69647249
123MP0008004_abnormal_stomach_pH0.69630033
124MP0010771_integument_phenotype0.69448792
125MP0003942_abnormal_urinary_system0.69398160
126MP0003755_abnormal_palate_morphology0.69086911
127MP0000432_abnormal_head_morphology0.68968151
128MP0001915_intracranial_hemorrhage0.68783122
129MP0002282_abnormal_trachea_morphology0.68407534
130MP0006138_congestive_heart_failure0.66587103
131MP0009250_abnormal_appendicular_skeleto0.66517866
132MP0000163_abnormal_cartilage_morphology0.66442512
133MP0002113_abnormal_skeleton_development0.66405040
134MP0008260_abnormal_autophagy0.66058880
135MP0000579_abnormal_nail_morphology0.63834820
136MP0002796_impaired_skin_barrier0.63476027
137MP0003868_abnormal_feces_composition0.62686360
138MP0004947_skin_inflammation0.60814252
139MP0000759_abnormal_skeletal_muscle0.59622598

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.07638372
2Protrusio acetabuli (HP:0003179)5.41220123
3Peritonitis (HP:0002586)3.98777308
4Aortic dissection (HP:0002647)3.95841445
5Aortic aneurysm (HP:0004942)3.53820093
6Cerebral aneurysm (HP:0004944)3.49801651
7Shallow orbits (HP:0000586)3.47151288
8Ankle contracture (HP:0006466)3.43929106
9Cervical subluxation (HP:0003308)3.39142407
10Deep venous thrombosis (HP:0002625)3.31755816
11Atrophic scars (HP:0001075)3.19352948
12Broad metatarsal (HP:0001783)3.14851934
13Osteolytic defects of the hand bones (HP:0009699)2.97859218
14Osteolytic defects of the phalanges of the hand (HP:0009771)2.97859218
15Myocardial infarction (HP:0001658)2.92803670
16Soft skin (HP:0000977)2.89217688
17Dilatation of the ascending aorta (HP:0005111)2.85844132
18Xanthomatosis (HP:0000991)2.76823044
19Abnormality of glycolipid metabolism (HP:0010969)2.75296463
20Abnormality of liposaccharide metabolism (HP:0010968)2.75296463
21Abnormality of glycosphingolipid metabolism (HP:0004343)2.75296463
22Mitral valve prolapse (HP:0001634)2.73167973
23Vascular tortuosity (HP:0004948)2.66874096
24Increased connective tissue (HP:0009025)2.64575633
25Fragile skin (HP:0001030)2.63761207
26Blue sclerae (HP:0000592)2.61951599
27Bladder diverticulum (HP:0000015)2.59361458
28Axonal loss (HP:0003447)2.57849427
29Wormian bones (HP:0002645)2.54897218
30Vertebral compression fractures (HP:0002953)2.53888267
31Type 1 muscle fiber predominance (HP:0003803)2.53129292
32Mitral stenosis (HP:0001718)2.49483204
33Complement deficiency (HP:0004431)2.48222262
34Spinal rigidity (HP:0003306)2.45788384
35Arterial tortuosity (HP:0005116)2.43595229
36Wrist flexion contracture (HP:0001239)2.41228143
37Abnormality of dentin (HP:0010299)2.39880241
38Aneurysm (HP:0002617)2.38870505
39Skin nodule (HP:0200036)2.31814187
40Short nail (HP:0001799)2.28926070
41Dysostosis multiplex (HP:0000943)2.28492517
42Mitral regurgitation (HP:0001653)2.28417726
43Infantile muscular hypotonia (HP:0008947)2.23076899
44Natal tooth (HP:0000695)2.22875045
45Cardiovascular calcification (HP:0011915)2.21904924
46Ulnar bowing (HP:0003031)2.21066520
47Genu recurvatum (HP:0002816)2.20392455
48Absent frontal sinuses (HP:0002688)2.19920024
49Increased cerebral lipofuscin (HP:0011813)2.17278713
50Aortic regurgitation (HP:0001659)2.17175322
51Follicular hyperkeratosis (HP:0007502)2.16947370
52Intrahepatic cholestasis (HP:0001406)2.16091016
53Nuclear cataract (HP:0100018)2.15900443
54Round ear (HP:0100830)2.14445082
55Distal upper limb amyotrophy (HP:0007149)2.12995752
56Upper limb amyotrophy (HP:0009129)2.12995752
57Joint laxity (HP:0001388)2.12146266
58Systemic lupus erythematosus (HP:0002725)2.10351665
59Broad face (HP:0000283)2.10235800
60Hyperextensible skin (HP:0000974)2.09851578
61Hyporeflexia of lower limbs (HP:0002600)2.09521625
62Urinary glycosaminoglycan excretion (HP:0003541)2.09404671
63Mucopolysacchariduria (HP:0008155)2.09404671
64Scapular winging (HP:0003691)2.07852672
65Focal segmental glomerulosclerosis (HP:0000097)2.07105969
66Turricephaly (HP:0000262)2.05944681
67Abnormality of complement system (HP:0005339)2.05067101
68Abnormal delivery (HP:0001787)2.04031202
69Ectopia lentis (HP:0001083)2.03593332
70Buphthalmos (HP:0000557)2.03306244
71Mildly elevated creatine phosphokinase (HP:0008180)2.01611671
72Abnormality of the common coagulation pathway (HP:0010990)1.99169498
73Hematochezia (HP:0002573)1.97947255
74Abnormality of proline metabolism (HP:0010907)1.97940281
75Hydroxyprolinuria (HP:0003080)1.97940281
76Tetraparesis (HP:0002273)1.97861797
77Thin bony cortex (HP:0002753)1.96033930
78Nephritis (HP:0000123)1.95886281
79Increased variability in muscle fiber diameter (HP:0003557)1.95545726
80Abnormality of the distal phalanges of the toes (HP:0010182)1.95374496
81Hypoalphalipoproteinemia (HP:0003233)1.94983463
82Vacuolated lymphocytes (HP:0001922)1.94952751
83Camptodactyly of toe (HP:0001836)1.94492142
84Neurofibrillary tangles (HP:0002185)1.92302068
85Cerebral inclusion bodies (HP:0100314)1.92135450
86Hyperacusis (HP:0010780)1.91718169
87Abnormality of carpal bone ossification (HP:0006257)1.91165981
88Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90377678
89Abnormality of polysaccharide metabolism (HP:0011012)1.90377678
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90377678
91Aortic valve stenosis (HP:0001650)1.89510538
92Abnormality of oral frenula (HP:0000190)1.88602917
93Distal lower limb amyotrophy (HP:0008944)1.88068747
94Spinal cord lesions (HP:0100561)1.87855852
95Syringomyelia (HP:0003396)1.87855852
96Ovoid vertebral bodies (HP:0003300)1.87473983
97Abnormal ossification of hand bones (HP:0005921)1.84155092
98Abnormality of glutamine family amino acid metabolism (HP:0010902)1.84141290
99Tibial bowing (HP:0002982)1.84070778
100Femoral bowing (HP:0002980)1.84062872
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84043228
102Abnormality of the Achilles tendon (HP:0005109)1.83942735
103Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83309875
104Bowel diverticulosis (HP:0005222)1.83202504
105Ankyloglossia (HP:0010296)1.82385457
106Flat acetabular roof (HP:0003180)1.82102266
107Right ventricular cardiomyopathy (HP:0011663)1.81749660
108Spondylolisthesis (HP:0003302)1.81267249
109Epidermoid cyst (HP:0200040)1.81224287
110Bowing of the arm (HP:0006488)1.79072899
111Bowed forearm bones (HP:0003956)1.79072899
112Long toe (HP:0010511)1.78221760
113Reduced subcutaneous adipose tissue (HP:0003758)1.78142989
114Back pain (HP:0003418)1.77908419
115Coronal craniosynostosis (HP:0004440)1.77650475
116Neonatal short-limb short stature (HP:0008921)1.77529760
117Vertebral arch anomaly (HP:0008438)1.77528855
118Coxa vara (HP:0002812)1.76927763
119Muscle fiber splitting (HP:0003555)1.76461408
120Abnormality of the acetabulum (HP:0003170)1.75726921
121Breech presentation (HP:0001623)1.75197572
122Overgrowth (HP:0001548)1.75180672
123Esophageal varix (HP:0002040)1.74844439
124Biconcave vertebral bodies (HP:0004586)1.74635320
125Vascular calcification (HP:0004934)1.74568367
126Subacute progressive viral hepatitis (HP:0006572)1.74011046
127Glomerulosclerosis (HP:0000096)1.73945908
128Elbow flexion contracture (HP:0002987)1.73755693
129Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.73425703
130Achilles tendon contracture (HP:0001771)1.73150948
131Abnormality of skull ossification (HP:0002703)1.73002704
132Radial bowing (HP:0002986)1.72548328
133Increased mean platelet volume (HP:0011877)1.71235731
134Wide anterior fontanel (HP:0000260)1.70456171
135Spastic diplegia (HP:0001264)1.69603839
136Hand muscle atrophy (HP:0009130)1.66542488
137Protruding ear (HP:0000411)1.64979561
138Pterygium (HP:0001059)1.64522594
139Joint stiffness (HP:0001387)1.64119217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.84539494
2TRIB33.77825745
3DDR22.93150743
4ERN12.84687124
5PDGFRA2.77286517
6IRAK32.62237213
7PKN22.56360090
8LATS12.38644395
9SIK12.32213688
10MET2.32005701
11EPHB12.06986249
12RIPK11.99292663
13BMX1.89039791
14PTK61.77952546
15FRK1.75847838
16TRPM71.72900154
17PTK21.66341696
18SCYL21.58489120
19NEK91.57147588
20EPHA21.56774404
21MST1R1.53512061
22PAK31.52115482
23NTRK11.51559874
24PAK21.51288799
25FER1.46829079
26CAMK1D1.44800543
27LRRK21.44314528
28TGFBR21.39600461
29PDGFRB1.38022756
30LIMK11.25756033
31EPHA31.21921579
32EPHB21.20014434
33STK391.19747151
34ERBB41.17743884
35JAK11.17724904
36MOS1.15877490
37PIM21.13054914
38STK31.10994587
39FGFR41.09130836
40LATS21.08545636
41CAMK1G1.07741030
42DMPK1.04688638
43FGFR21.02786191
44ARAF1.01262570
45TBK10.97126338
46CDC42BPA0.94630177
47TESK10.94414348
48PAK40.92650659
49STK380.91661543
50CDK120.86898510
51RET0.86843770
52STK38L0.85743713
53MAP3K20.85265447
54PBK0.85041543
55MAP3K120.84565466
56ABL20.83915549
57PIK3CA0.83491697
58FGFR10.80612764
59MAP2K10.79874918
60NME20.79757092
61ROCK10.79392292
62PRKD10.78225457
63KSR10.76123365
64NEK10.76042307
65PIK3CG0.75545788
66KSR20.74290514
67GRK70.73655141
68EIF2AK10.72748892
69MTOR0.72615996
70PTK2B0.72113524
71BCKDK0.71727642
72PAK60.69876746
73GSK3A0.69539674
74STK100.69470845
75CDK80.69083540
76FLT30.68892462
77INSR0.68410337
78WNK40.67987684
79ROCK20.67473562
80CSK0.67186212
81TAOK30.66687287
82PRKCH0.66441308
83FGR0.65791390
84TYK20.64070787
85CAMKK10.63680980
86MAP3K30.63611962
87PRKG20.63598414
88DYRK1B0.63246391
89PDK20.61986016
90MELK0.60709284
91BCR0.60531268
92EGFR0.59010516
93MAP3K80.58221860
94MAP3K140.57994398
95ICK0.57322549
96MYLK0.57172544
97PDPK10.55401315
98PRKD20.54956239
99AKT30.54368325
100OXSR10.53735203
101PRKD30.53678247
102ILK0.51922650
103MAP3K130.51091405
104TAOK20.51043056
105CDK60.48954381
106BMPR20.48787001
107FGFR30.48162830
108RPS6KA20.47411233
109WNK10.46189085
110SRC0.46185395
111CAMKK20.46119522
112MAP3K60.44825725
113LMTK20.44677667
114IGF1R0.44597391
115JAK20.43987467
116RPS6KA40.43138132
117CAMK2G0.42992675
118EEF2K0.42264502
119ABL10.42129759
120MAP2K30.41641807
121JAK30.40627206
122STK240.39108893
123PLK20.37877857
124CSF1R0.37108171
125FYN0.36481099
126CLK10.35914469
127ERBB30.35534992
128CDK90.35001671
129PRKCE0.34580093
130KIT0.34472981
131INSRR0.33939538
132CAMK2D0.33913178
133EIF2AK30.31762521
134SMG10.31404727
135CAMK2B0.29672278
136MAP3K90.29532116
137MAPKAPK30.28382435

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.46722102
2ECM-receptor interaction_Homo sapiens_hsa045122.22783873
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.15977212
4Complement and coagulation cascades_Homo sapiens_hsa046102.15244265
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02350606
6Staphylococcus aureus infection_Homo sapiens_hsa051501.85696365
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80228714
8Focal adhesion_Homo sapiens_hsa045101.74349946
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71464435
10Lysosome_Homo sapiens_hsa041421.68565658
11PPAR signaling pathway_Homo sapiens_hsa033201.64408874
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64017037
13Arginine biosynthesis_Homo sapiens_hsa002201.63799932
14Fatty acid degradation_Homo sapiens_hsa000711.63460004
15Steroid biosynthesis_Homo sapiens_hsa001001.55249202
16Amoebiasis_Homo sapiens_hsa051461.53463276
17Caffeine metabolism_Homo sapiens_hsa002321.51912854
18Malaria_Homo sapiens_hsa051441.50057890
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46622515
20Fatty acid metabolism_Homo sapiens_hsa012121.44537032
21Vibrio cholerae infection_Homo sapiens_hsa051101.42478884
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37249119
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36479268
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.33085289
25Proteoglycans in cancer_Homo sapiens_hsa052051.30942569
26Galactose metabolism_Homo sapiens_hsa000521.28169002
27Sulfur metabolism_Homo sapiens_hsa009201.27981572
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27796873
29Tryptophan metabolism_Homo sapiens_hsa003801.27582319
30Hippo signaling pathway_Homo sapiens_hsa043901.15139224
31Phagosome_Homo sapiens_hsa041451.15086212
32N-Glycan biosynthesis_Homo sapiens_hsa005101.12119744
33Sphingolipid metabolism_Homo sapiens_hsa006001.09646616
34Butanoate metabolism_Homo sapiens_hsa006501.07604666
35Propanoate metabolism_Homo sapiens_hsa006401.07511677
36Bile secretion_Homo sapiens_hsa049761.06575177
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05290499
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04122929
39Adherens junction_Homo sapiens_hsa045201.04051472
40Bladder cancer_Homo sapiens_hsa052191.02183260
41Pentose phosphate pathway_Homo sapiens_hsa000301.01729702
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01610155
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01251301
44Dilated cardiomyopathy_Homo sapiens_hsa054141.00733039
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98509909
46Thyroid cancer_Homo sapiens_hsa052160.98148367
47Chemical carcinogenesis_Homo sapiens_hsa052040.97744471
48Small cell lung cancer_Homo sapiens_hsa052220.97550649
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96421685
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96407931
51Histidine metabolism_Homo sapiens_hsa003400.94022689
52Starch and sucrose metabolism_Homo sapiens_hsa005000.93916868
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91379140
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89947282
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89887545
56Pathways in cancer_Homo sapiens_hsa052000.88865402
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87817227
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87726000
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86720668
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.86153357
61Fructose and mannose metabolism_Homo sapiens_hsa000510.85507586
62Peroxisome_Homo sapiens_hsa041460.85441640
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84187312
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83004792
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.81500910
66Prion diseases_Homo sapiens_hsa050200.81157832
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80375335
68Protein digestion and absorption_Homo sapiens_hsa049740.79767163
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79672611
70Axon guidance_Homo sapiens_hsa043600.76567034
71Fatty acid biosynthesis_Homo sapiens_hsa000610.76148086
72Endometrial cancer_Homo sapiens_hsa052130.76107885
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75894769
74Prostate cancer_Homo sapiens_hsa052150.73491901
75Fatty acid elongation_Homo sapiens_hsa000620.71784279
76Pertussis_Homo sapiens_hsa051330.71668708
77Chronic myeloid leukemia_Homo sapiens_hsa052200.70999330
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70772756
79Salmonella infection_Homo sapiens_hsa051320.69754340
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.68726209
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66600861
82Viral myocarditis_Homo sapiens_hsa054160.66385389
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65295633
84Gap junction_Homo sapiens_hsa045400.65136602
85Arginine and proline metabolism_Homo sapiens_hsa003300.64754266
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.64661723
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64578133
88Insulin resistance_Homo sapiens_hsa049310.63975173
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63458114
90Leishmaniasis_Homo sapiens_hsa051400.63329999
91beta-Alanine metabolism_Homo sapiens_hsa004100.62858208
92Renal cell carcinoma_Homo sapiens_hsa052110.62403140
93ErbB signaling pathway_Homo sapiens_hsa040120.62077181
94Tight junction_Homo sapiens_hsa045300.61011056
95Pancreatic cancer_Homo sapiens_hsa052120.60909288
96Toxoplasmosis_Homo sapiens_hsa051450.60133795
97Pyruvate metabolism_Homo sapiens_hsa006200.59441134
98Thyroid hormone synthesis_Homo sapiens_hsa049180.58990859
99Vitamin B6 metabolism_Homo sapiens_hsa007500.58455681
100Rap1 signaling pathway_Homo sapiens_hsa040150.58316431
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57094934
102Shigellosis_Homo sapiens_hsa051310.56616480
103ABC transporters_Homo sapiens_hsa020100.56261668
104Other glycan degradation_Homo sapiens_hsa005110.56236799
105Retinol metabolism_Homo sapiens_hsa008300.55957091
106MicroRNAs in cancer_Homo sapiens_hsa052060.55863519
107HIF-1 signaling pathway_Homo sapiens_hsa040660.55859175
108Carbon metabolism_Homo sapiens_hsa012000.55420575
109Melanoma_Homo sapiens_hsa052180.54509936
110Tuberculosis_Homo sapiens_hsa051520.54094721
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.54017163
112Hepatitis C_Homo sapiens_hsa051600.53931241
113TNF signaling pathway_Homo sapiens_hsa046680.53475527
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53319214
115TGF-beta signaling pathway_Homo sapiens_hsa043500.52398387
116Apoptosis_Homo sapiens_hsa042100.52298219
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52095881
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52055009
119Phenylalanine metabolism_Homo sapiens_hsa003600.51695925
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.50508805
121p53 signaling pathway_Homo sapiens_hsa041150.50461109
122Notch signaling pathway_Homo sapiens_hsa043300.50444183
123Glioma_Homo sapiens_hsa052140.50433415
124Fat digestion and absorption_Homo sapiens_hsa049750.50020016
125Osteoclast differentiation_Homo sapiens_hsa043800.49862100
126Platelet activation_Homo sapiens_hsa046110.49673474
127Rheumatoid arthritis_Homo sapiens_hsa053230.48478984
128Insulin signaling pathway_Homo sapiens_hsa049100.47289452
129Endocytosis_Homo sapiens_hsa041440.47154207
130Biosynthesis of amino acids_Homo sapiens_hsa012300.47020281
131Estrogen signaling pathway_Homo sapiens_hsa049150.46739779
132Non-small cell lung cancer_Homo sapiens_hsa052230.46594081
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46488042
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46226279
135mTOR signaling pathway_Homo sapiens_hsa041500.45727777
136Selenocompound metabolism_Homo sapiens_hsa004500.45474485
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.45294616
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45025538
139Hepatitis B_Homo sapiens_hsa051610.44741671
140VEGF signaling pathway_Homo sapiens_hsa043700.43702756
141Glutathione metabolism_Homo sapiens_hsa004800.43440039
142Tyrosine metabolism_Homo sapiens_hsa003500.43392272
143Renin-angiotensin system_Homo sapiens_hsa046140.41910223
144Lysine degradation_Homo sapiens_hsa003100.40149962
145Melanogenesis_Homo sapiens_hsa049160.39261125
146Hedgehog signaling pathway_Homo sapiens_hsa043400.37583909
147Basal cell carcinoma_Homo sapiens_hsa052170.37213191
148Prolactin signaling pathway_Homo sapiens_hsa049170.36046226
149AMPK signaling pathway_Homo sapiens_hsa041520.34302168

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