ADAMDEC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)9.31616855
2angiotensin maturation (GO:0002003)7.24622484
3bile acid and bile salt transport (GO:0015721)6.64369331
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.87701514
5intestinal absorption (GO:0050892)5.78737990
6maintenance of gastrointestinal epithelium (GO:0030277)5.78498736
7sulfur amino acid catabolic process (GO:0000098)5.26838339
8regulation of bile acid biosynthetic process (GO:0070857)5.13239442
9regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.04556636
10cellular glucuronidation (GO:0052695)5.02297819
11regulation of vitamin metabolic process (GO:0030656)4.96188096
12glycosphingolipid catabolic process (GO:0046479)4.93359637
13fat-soluble vitamin biosynthetic process (GO:0042362)4.85231632
14O-glycan processing (GO:0016266)4.79374101
15flavonoid metabolic process (GO:0009812)4.73781624
16epithelial structure maintenance (GO:0010669)4.70655302
17regulation of mononuclear cell migration (GO:0071675)4.68206895
18glycolipid catabolic process (GO:0019377)4.65015559
19intestinal epithelial cell development (GO:0060576)4.57638082
20uronic acid metabolic process (GO:0006063)4.55051018
21glucuronate metabolic process (GO:0019585)4.55051018
22purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.38269031
233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.38269031
24adhesion of symbiont to host cell (GO:0044650)4.35540882
25virion attachment to host cell (GO:0019062)4.35540882
26regulation of cellular extravasation (GO:0002691)4.35474327
27regulation of guanylate cyclase activity (GO:0031282)4.20943410
28immunoglobulin mediated immune response (GO:0016064)4.19618638
29eosinophil chemotaxis (GO:0048245)4.17399458
30lipoprotein transport (GO:0042953)4.04393657
31ceramide catabolic process (GO:0046514)3.94533891
32peptide catabolic process (GO:0043171)3.92603959
33regulation of cholesterol homeostasis (GO:2000188)3.91706467
34xenobiotic catabolic process (GO:0042178)3.90789288
35nucleotide-sugar biosynthetic process (GO:0009226)3.88799045
36bile acid metabolic process (GO:0008206)3.88103891
37nucleotide-sugar metabolic process (GO:0009225)3.82583577
38actin filament depolymerization (GO:0030042)3.80345462
39hypotonic response (GO:0006971)3.78001718
40thrombin receptor signaling pathway (GO:0070493)3.76789910
41regulation of vitamin D biosynthetic process (GO:0060556)3.76050767
42sulfation (GO:0051923)3.74903730
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.74151512
44hemidesmosome assembly (GO:0031581)3.71043558
45digestive system process (GO:0022600)3.69888308
46eosinophil migration (GO:0072677)3.69780679
47kidney morphogenesis (GO:0060993)3.68153186
48membrane lipid catabolic process (GO:0046466)3.68122184
49adhesion of symbiont to host (GO:0044406)3.68004817
50oligosaccharide catabolic process (GO:0009313)3.67379510
51sphingolipid catabolic process (GO:0030149)3.66231865
52NADH metabolic process (GO:0006734)3.63222665
53homocysteine metabolic process (GO:0050667)3.59758517
54positive regulation of actin filament depolymerization (GO:0030836)3.58929103
55extracellular matrix assembly (GO:0085029)3.53958599
56epoxygenase P450 pathway (GO:0019373)3.53064953
57regulation of macrophage chemotaxis (GO:0010758)3.53004718
58fructose metabolic process (GO:0006000)3.47218083
59interferon-gamma-mediated signaling pathway (GO:0060333)3.45822599
60positive regulation of antigen processing and presentation (GO:0002579)3.44785034
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40225066
62regulation of antigen processing and presentation (GO:0002577)3.38029624
63response to nitrosative stress (GO:0051409)3.37650623
64drug catabolic process (GO:0042737)3.37243476
65T-helper 1 type immune response (GO:0042088)3.35782723
66regulation of cytokine secretion involved in immune response (GO:0002739)3.35584713
67phospholipid homeostasis (GO:0055091)3.35356850
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32329169
69sulfate transmembrane transport (GO:1902358)3.31013769
70negative regulation of interleukin-12 production (GO:0032695)3.26570844
71intestinal cholesterol absorption (GO:0030299)3.24355651
72midgut development (GO:0007494)3.24133721
73production of molecular mediator of immune response (GO:0002440)3.22708938
74hepatocyte apoptotic process (GO:0097284)3.20992090
75ethanol metabolic process (GO:0006067)3.15364771
76branching involved in labyrinthine layer morphogenesis (GO:0060670)3.09957633
77cGMP-mediated signaling (GO:0019934)3.09188300
78drug transmembrane transport (GO:0006855)3.04269042
79regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.03826197
80endocrine process (GO:0050886)3.03826197
81regulation of systemic arterial blood pressure by hormone (GO:0001990)3.03826197
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03798344
83regulation of podosome assembly (GO:0071801)3.02797937
84B cell mediated immunity (GO:0019724)3.01602270
85positive regulation of guanylate cyclase activity (GO:0031284)3.00605791
86respiratory tube development (GO:0030323)2.96874533
87exogenous drug catabolic process (GO:0042738)2.95887412
88endocardial cushion development (GO:0003197)2.94625955
89NIK/NF-kappaB signaling (GO:0038061)2.93169166
90cellular response to thyroid hormone stimulus (GO:0097067)2.92740817
91cellular response to type I interferon (GO:0071357)2.91948736
92type I interferon signaling pathway (GO:0060337)2.91948736
93phospholipid efflux (GO:0033700)2.91745802
94cellular response to interferon-gamma (GO:0071346)2.91003481
95regulation of cholesterol storage (GO:0010885)2.90220713
96transcytosis (GO:0045056)2.89945427
97response to type I interferon (GO:0034340)2.88480543
98positive regulation of pseudopodium assembly (GO:0031274)2.87476275
99desmosome organization (GO:0002934)2.86925917
100positive regulation of chemokine biosynthetic process (GO:0045080)2.86169845
101mesodermal cell differentiation (GO:0048333)2.85953551
102regulation of T-helper 1 cell differentiation (GO:0045625)2.84193416
103protein O-linked glycosylation (GO:0006493)2.82652166
104positive regulation of Cdc42 GTPase activity (GO:0043089)2.82559322
105detection of other organism (GO:0098543)2.79038094
106monocyte chemotaxis (GO:0002548)2.76315690
107macrophage activation involved in immune response (GO:0002281)2.75467427
108diacylglycerol metabolic process (GO:0046339)2.75005924
109ventricular cardiac muscle cell action potential (GO:0086005)2.74150322
110response to interferon-gamma (GO:0034341)2.73851486
111regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.73799180
112myeloid dendritic cell differentiation (GO:0043011)2.73304027
113urea metabolic process (GO:0019627)2.73300361
114urea cycle (GO:0000050)2.73300361
115regulation of systemic arterial blood pressure (GO:0003073)2.72900623
116lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72809872
117positive regulation of type 2 immune response (GO:0002830)2.72283007
118neutrophil activation involved in immune response (GO:0002283)2.71329107
119cyclooxygenase pathway (GO:0019371)2.69625525
120hormone catabolic process (GO:0042447)2.69542105
121very-low-density lipoprotein particle assembly (GO:0034379)2.68874065
122detection of bacterium (GO:0016045)2.67846816
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67672845
124lipid translocation (GO:0034204)2.67598431
125phospholipid translocation (GO:0045332)2.67598431
126nucleotide transmembrane transport (GO:1901679)2.65485619
127primary alcohol catabolic process (GO:0034310)2.64800518
128response to peptidoglycan (GO:0032494)2.64598368
129benzene-containing compound metabolic process (GO:0042537)2.64417156
130relaxation of cardiac muscle (GO:0055119)2.63707045
131renal system process involved in regulation of blood volume (GO:0001977)2.63667480
132antigen processing and presentation of endogenous antigen (GO:0019883)2.63512461
133peptide hormone processing (GO:0016486)2.62642551
134regulation of cGMP biosynthetic process (GO:0030826)2.61566318
135drug metabolic process (GO:0017144)2.61549567
136bicarbonate transport (GO:0015701)2.59293181
137glutathione derivative biosynthetic process (GO:1901687)2.57675873
138glutathione derivative metabolic process (GO:1901685)2.57675873
139positive regulation of lipoprotein lipase activity (GO:0051006)2.56375409
140positive regulation of triglyceride lipase activity (GO:0061365)2.56375409
141lipoprotein metabolic process (GO:0042157)2.56337773
142regulation of chemokine biosynthetic process (GO:0045073)2.55076368
143negative regulation of steroid metabolic process (GO:0045939)2.54857440
144regulation of fever generation (GO:0031620)2.54357588
145regulation of pseudopodium assembly (GO:0031272)2.53442401
146transepithelial transport (GO:0070633)2.52963886
147low-density lipoprotein particle remodeling (GO:0034374)2.52511022
148alpha-linolenic acid metabolic process (GO:0036109)2.52393181
149cell adhesion mediated by integrin (GO:0033627)2.52299541
150lung secretory cell differentiation (GO:0061140)2.52168790
151glucose 6-phosphate metabolic process (GO:0051156)2.49827259
152positive regulation of heat generation (GO:0031652)2.49367388
153regulation of cholesterol esterification (GO:0010872)2.49033103
154sulfate transport (GO:0008272)2.48894005
155fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48715631
156negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.48570121
157cellular ketone body metabolic process (GO:0046950)2.47785004
158regulation of interferon-beta biosynthetic process (GO:0045357)2.46877159
159negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46205085
160complement activation, classical pathway (GO:0006958)2.45071747
161negative regulation of sterol transport (GO:0032372)2.44911850
162negative regulation of cholesterol transport (GO:0032375)2.44911850
163vitamin D metabolic process (GO:0042359)2.44674965
164amino sugar metabolic process (GO:0006040)2.44166077
165lung vasculature development (GO:0060426)2.44102247
166antibacterial humoral response (GO:0019731)2.43324498
167cell communication involved in cardiac conduction (GO:0086065)2.42804509
168dendritic cell chemotaxis (GO:0002407)2.42691346
169receptor guanylyl cyclase signaling pathway (GO:0007168)2.42628611
170plasma lipoprotein particle assembly (GO:0034377)2.42393033
171drug transport (GO:0015893)2.41719263
172protein-lipid complex assembly (GO:0065005)2.39812535
173ethanol oxidation (GO:0006069)2.39211017
174alkaloid metabolic process (GO:0009820)2.38598497
175antimicrobial humoral response (GO:0019730)2.38591309
176epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38349625
177sterol homeostasis (GO:0055092)2.38242360
178cholesterol homeostasis (GO:0042632)2.38186157
179lung lobe morphogenesis (GO:0060463)2.37889378
180apoptotic cell clearance (GO:0043277)2.34852229
181nitrogen cycle metabolic process (GO:0071941)2.33776778
182galactose catabolic process (GO:0019388)2.33568819
183negative regulation of steroid biosynthetic process (GO:0010894)2.33062394
184establishment of epithelial cell polarity (GO:0090162)2.32176763
185xenobiotic metabolic process (GO:0006805)2.30507230
186growth hormone receptor signaling pathway (GO:0060396)2.29760993
187sulfur compound transport (GO:0072348)2.28805950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.44928279
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.88989699
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.53135164
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.22628798
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.71554307
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.69988588
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.17479374
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.06733363
9SOX2_27498859_Chip-Seq_STOMACH_Mouse3.02753359
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.02279150
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.92271946
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.91508276
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.88142636
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80254656
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.71298177
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.70386552
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69763420
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.69043904
19CLOCK_20551151_ChIP-Seq_293T_Human2.49946761
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47308117
21SOX2_20726797_ChIP-Seq_SW620_Human2.23469537
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.20972125
23GATA1_22025678_ChIP-Seq_K562_Human2.15300869
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.15285940
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.15222168
26GATA4_25053715_ChIP-Seq_YYC3_Human2.07266512
27PPAR_26484153_Chip-Seq_NCI-H1993_Human2.04822133
28ESR1_20079471_ChIP-ChIP_T-47D_Human2.01955240
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98425651
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98423846
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97990837
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96605197
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96061674
34GATA6_25053715_ChIP-Seq_YYC3_Human1.94838851
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.92672116
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91485718
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.90465599
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87449840
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87004744
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86920322
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.86881356
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83440671
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.78044097
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75270483
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74340575
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73398023
47* VDR_24763502_ChIP-Seq_THP-1_Human1.65051337
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.62004009
49LXR_22292898_ChIP-Seq_THP-1_Human1.61470396
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56133268
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55779046
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52178990
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50805356
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50603751
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50603751
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50020421
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47187256
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42850114
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42740299
60SPI1_23127762_ChIP-Seq_K562_Human1.42347913
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.41855381
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40382366
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38171265
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37843193
65KLF5_25053715_ChIP-Seq_YYC3_Human1.37069827
66* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35550168
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35357760
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32951299
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31187785
70VDR_21846776_ChIP-Seq_THP-1_Human1.30209070
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30121726
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29936778
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29679258
74AR_21909140_ChIP-Seq_LNCAP_Human1.24053583
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.23602923
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23448267
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.23372902
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22554914
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22299122
80SPI1_23547873_ChIP-Seq_NB4_Human1.22231301
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21473331
82CJUN_26792858_Chip-Seq_BT549_Human1.20976387
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20571699
84TP53_16413492_ChIP-PET_HCT116_Human1.20338121
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18895171
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18895171
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18458851
88ZNF263_19887448_ChIP-Seq_K562_Human1.18443637
89* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18036327
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16862736
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16449112
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15907149
93STAT1_20625510_ChIP-Seq_HELA_Human1.14328446
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14284441
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13285063
96EGR1_19032775_ChIP-ChIP_M12_Human1.13263302
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12011515
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11662320
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11438034
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11168156
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09360452
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09360452
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09360452
104GATA2_19941826_ChIP-Seq_K562_Human1.09159353
105STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09006988
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08984789
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08025447
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07744992
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07445912
110RXR_22108803_ChIP-Seq_LS180_Human1.07089415
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.06828778
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05303988
113RACK7_27058665_Chip-Seq_MCF-7_Human1.03355316
114FOXA1_25552417_ChIP-Seq_VCAP_Human1.02913770
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02514754
116DROSHA_22980978_ChIP-Seq_HELA_Human1.02200302
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01967716
118BCL6_27268052_Chip-Seq_Bcells_Human1.01821638
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.99634100
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.99509183
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99267317
122BCOR_27268052_Chip-Seq_Bcells_Human0.98665063
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97950411
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97586770
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.96983156
126EGR1_19374776_ChIP-ChIP_THP-1_Human0.96474966
127GATA1_19941826_ChIP-Seq_K562_Human0.96361557
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96356745
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.96326399
130* VDR_24787735_ChIP-Seq_THP-1_Human0.96245309
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.95867680
132BCAT_22108803_ChIP-Seq_LS180_Human0.95789850
133TP53_18474530_ChIP-ChIP_U2OS_Human0.95057217
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94745375
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94726556
136AHR_22903824_ChIP-Seq_MCF-7_Human0.94207820
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93897972
138RUNX_20019798_ChIP-Seq_JUKART_Human0.92076660
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91633889
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90376493
141SA1_27219007_Chip-Seq_Bcells_Human0.90264520
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89261303
143SCL_19346495_ChIP-Seq_HPC-7_Human0.88835576
144KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88284524
145P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87933815
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86934145
147TP63_23658742_ChIP-Seq_EP156T_Human0.86583130
148HNF4A_19822575_ChIP-Seq_HepG2_Human0.84574180
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83948628
150FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83866909
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83823799
152PU_27001747_Chip-Seq_BMDM_Mouse0.83371485
153CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82706270
154GATA3_24758297_ChIP-Seq_MCF-7_Human0.81858174
155MYB_26560356_Chip-Seq_TH2_Human0.80568214
156FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80392354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005085_abnormal_gallbladder_physiolo4.92593204
2MP0005365_abnormal_bile_salt4.45924890
3MP0010234_abnormal_vibrissa_follicle4.04221385
4MP0005360_urolithiasis3.90664692
5MP0001666_abnormal_nutrient_absorption3.66281538
6MP0008875_abnormal_xenobiotic_pharmacok3.60533043
7MP0004264_abnormal_extraembryonic_tissu3.20843603
8MP0000462_abnormal_digestive_system3.14606117
9MP0006054_spinal_hemorrhage2.95895973
10MP0003866_abnormal_defecation2.92438005
11MP0003183_abnormal_peptide_metabolism2.85595793
12MP0005058_abnormal_lysosome_morphology2.80890783
13MP0002139_abnormal_hepatobiliary_system2.77247907
14MP0001873_stomach_inflammation2.74889459
15MP0003252_abnormal_bile_duct2.74544665
16MP0010155_abnormal_intestine_physiology2.72746928
17MP0003300_gastrointestinal_ulcer2.69048263
18MP0006082_CNS_inflammation2.68394929
19MP0001835_abnormal_antigen_presentation2.66151815
20MP0009785_altered_susceptibility_to2.57565207
21MP0002148_abnormal_hypersensitivity_rea2.57424630
22MP0001663_abnormal_digestive_system2.50743398
23MP0002822_catalepsy2.48443313
24MP0003868_abnormal_feces_composition2.46934967
25MP0003436_decreased_susceptibility_to2.45698807
26MP0010352_gastrointestinal_tract_polyps2.45386259
27MP0005381_digestive/alimentary_phenotyp2.41879637
28MP0005671_abnormal_response_to2.21684775
29MP0001790_abnormal_immune_system2.16124681
30MP0005387_immune_system_phenotype2.16124681
31MP0001664_abnormal_digestion2.10977991
32MP0005025_abnormal_response_to2.05663571
33MP0003705_abnormal_hypodermis_morpholog2.03494728
34MP0005167_abnormal_blood-brain_barrier2.01077407
35MP0000604_amyloidosis2.00244376
36MP0005000_abnormal_immune_tolerance1.93053095
37MP0002419_abnormal_innate_immunity1.87544571
38MP0000477_abnormal_intestine_morphology1.77469870
39MP0008004_abnormal_stomach_pH1.76491775
40MP0003191_abnormal_cellular_cholesterol1.70935799
41MP0000537_abnormal_urethra_morphology1.65546380
42MP0002254_reproductive_system_inflammat1.64702055
43MP0010329_abnormal_lipoprotein_level1.63175154
44MP0003806_abnormal_nucleotide_metabolis1.61784505
45MP0002452_abnormal_antigen_presenting1.61617118
46MP0005451_abnormal_body_composition1.61362903
47MP0001800_abnormal_humoral_immune1.59778866
48MP0001533_abnormal_skeleton_physiology1.56200152
49MP0005275_abnormal_skin_tensile1.53101298
50MP0002723_abnormal_immune_serum1.52231860
51MP0000685_abnormal_immune_system1.51808487
52MP0003303_peritoneal_inflammation1.51383773
53MP0003172_abnormal_lysosome_physiology1.48160479
54MP0008469_abnormal_protein_level1.47839469
55MP0003878_abnormal_ear_physiology1.46433247
56MP0005377_hearing/vestibular/ear_phenot1.46433247
57MP0000538_abnormal_urinary_bladder1.42418807
58MP0000465_gastrointestinal_hemorrhage1.40667974
59MP0000343_altered_response_to1.39984526
60MP0004510_myositis1.38848698
61MP0004147_increased_porphyrin_level1.35329576
62MP0000490_abnormal_crypts_of1.34299985
63MP0002060_abnormal_skin_morphology1.33232792
64MP0003566_abnormal_cell_adhesion1.31105621
65MP0008438_abnormal_cutaneous_collagen1.30974245
66MP0002998_abnormal_bone_remodeling1.30939266
67MP0001819_abnormal_immune_cell1.28032504
68MP0003448_altered_tumor_morphology1.26583770
69MP0002420_abnormal_adaptive_immunity1.25497174
70MP0002277_abnormal_respiratory_mucosa1.25478214
71MP0003724_increased_susceptibility_to1.21548476
72MP0009053_abnormal_anal_canal1.19423679
73MP0003941_abnormal_skin_development1.15858614
74MP0009379_abnormal_foot_pigmentation1.11219953
75MP0009333_abnormal_splenocyte_physiolog1.10302285
76MP0000470_abnormal_stomach_morphology1.09479636
77MP0010678_abnormal_skin_adnexa1.09300091
78MP0003453_abnormal_keratinocyte_physiol1.09134678
79MP0000609_abnormal_liver_physiology1.08925269
80MP0000467_abnormal_esophagus_morphology1.06897313
81MP0003329_amyloid_beta_deposits1.06424224
82MP0004947_skin_inflammation1.06192767
83MP0009384_cardiac_valve_regurgitation1.05238541
84MP0002166_altered_tumor_susceptibility1.04607026
85MP0010368_abnormal_lymphatic_system1.03197061
86MP0001764_abnormal_homeostasis1.02292084
87MP0002877_abnormal_melanocyte_morpholog1.00098017
88MP0005409_darkened_coat_color0.93839990
89MP0009643_abnormal_urine_homeostasis0.93781656
90MP0009840_abnormal_foam_cell0.92942088
91MP0000858_altered_metastatic_potential0.92775938
92MP0001853_heart_inflammation0.90435599
93MP0001765_abnormal_ion_homeostasis0.90199849
94MP0001849_ear_inflammation0.89477092
95MP0001501_abnormal_sleep_pattern0.89396173
96MP0002138_abnormal_hepatobiliary_system0.89097043
97MP0005332_abnormal_amino_acid0.88873921
98MP0005166_decreased_susceptibility_to0.88345704
99MP0005464_abnormal_platelet_physiology0.87128208
100MP0004019_abnormal_vitamin_homeostasis0.85718817
101MP0005584_abnormal_enzyme/coenzyme_acti0.85507443
102MP0005408_hypopigmentation0.84628025
103MP0000716_abnormal_immune_system0.84612796
104MP0003879_abnormal_hair_cell0.84583167
105MP0002118_abnormal_lipid_homeostasis0.84017332
106MP0005023_abnormal_wound_healing0.83718149
107MP0000249_abnormal_blood_vessel0.83593002
108MP0002405_respiratory_system_inflammati0.82889240
109MP0004858_abnormal_nervous_system0.82361275
110MP0005319_abnormal_enzyme/_coenzyme0.82175875
111MP0004043_abnormal_pH_regulation0.81253205
112MP0002796_impaired_skin_barrier0.80664047
113MP0003690_abnormal_glial_cell0.80459175
114MP0005165_increased_susceptibility_to0.80126511
115MP0003045_fibrosis0.78873632
116MP0009764_decreased_sensitivity_to0.78472665
117MP0000613_abnormal_salivary_gland0.78297099
118MP0005535_abnormal_body_temperature0.77492403
119MP0002006_tumorigenesis0.76797100
120MP0003091_abnormal_cell_migration0.76772405
121MP0005248_abnormal_Harderian_gland0.74338608
122MP0009763_increased_sensitivity_to0.73766291
123MP0002098_abnormal_vibrissa_morphology0.73747448
124MP0001845_abnormal_inflammatory_respons0.73171556
125MP0001756_abnormal_urination0.72326444
126MP0000678_abnormal_parathyroid_gland0.71280104
127MP0004272_abnormal_basement_membrane0.70027266
128MP0008873_increased_physiological_sensi0.69589529
129MP0005636_abnormal_mineral_homeostasis0.69202050
130MP0003075_altered_response_to0.67287389
131MP0000920_abnormal_myelination0.66783206
132MP0005187_abnormal_penis_morphology0.63723997
133MP0010030_abnormal_orbit_morphology0.62582989
134MP0001243_abnormal_dermal_layer0.61666057
135MP0001216_abnormal_epidermal_layer0.61446965
136MP0002896_abnormal_bone_mineralization0.59968429
137MP0008872_abnormal_physiological_respon0.57271888
138MP0002136_abnormal_kidney_physiology0.56202067
139MP0003283_abnormal_digestive_organ0.52690871
140MP0000762_abnormal_tongue_morphology0.52685664
141MP0002009_preneoplasia0.51306938
142MP0005310_abnormal_salivary_gland0.49217757
143MP0005076_abnormal_cell_differentiation0.48298988
144MP0010386_abnormal_urinary_bladder0.47826012
145MP0005083_abnormal_biliary_tract0.47235103
146MP0004130_abnormal_muscle_cell0.46649119
147MP0009278_abnormal_bone_marrow0.44723633
148MP0003385_abnormal_body_wall0.44500262

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.22067072
2Ileus (HP:0002595)6.86773378
3Right ventricular cardiomyopathy (HP:0011663)6.17047071
4Abnormality of liposaccharide metabolism (HP:0010968)5.28213048
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.28213048
6Abnormality of glycolipid metabolism (HP:0010969)5.28213048
7Aortic aneurysm (HP:0004942)4.75134685
8Intrahepatic cholestasis (HP:0001406)4.61411423
9Conjugated hyperbilirubinemia (HP:0002908)4.33577404
10Fat malabsorption (HP:0002630)4.25108565
11Vacuolated lymphocytes (HP:0001922)4.24799865
12Glomerulonephritis (HP:0000099)4.14570106
13Gastrointestinal dysmotility (HP:0002579)4.11531050
14Rectal prolapse (HP:0002035)3.95253289
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.85198601
16Chronic diarrhea (HP:0002028)3.74341253
17Abnormality of macrophages (HP:0004311)3.73361160
18Aortic dissection (HP:0002647)3.68726794
19Increased connective tissue (HP:0009025)3.59204104
20Malnutrition (HP:0004395)3.52502747
21Recurrent bacterial skin infections (HP:0005406)3.48523827
22Dysostosis multiplex (HP:0000943)3.47679125
23Mildly elevated creatine phosphokinase (HP:0008180)3.40726554
24Flat acetabular roof (HP:0003180)3.40130224
25Disinhibition (HP:0000734)3.36728938
26Nausea (HP:0002018)3.29827402
27Increased cerebral lipofuscin (HP:0011813)3.25333470
28Recurrent abscess formation (HP:0002722)3.24347411
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.14910299
30Loss of speech (HP:0002371)3.12930030
31Abdominal distention (HP:0003270)3.06803255
32Widely patent fontanelles and sutures (HP:0004492)2.99998932
33Abnormal biliary tract morphology (HP:0012440)2.97812667
34Milia (HP:0001056)2.97301070
35Abnormality of complement system (HP:0005339)2.95357546
36Hyperactive renin-angiotensin system (HP:0000841)2.95084228
37Steatorrhea (HP:0002570)2.89437326
38Abnormality of the distal phalanx of the thumb (HP:0009617)2.84970540
39Thin bony cortex (HP:0002753)2.81919277
40Ankle contracture (HP:0006466)2.80370129
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.79781419
42Osteolytic defects of the hand bones (HP:0009699)2.79781419
43Axonal loss (HP:0003447)2.78016268
44Orchitis (HP:0100796)2.77719505
45Gingivitis (HP:0000230)2.76222630
46Atrophic scars (HP:0001075)2.74804182
47Deep venous thrombosis (HP:0002625)2.72435868
48Autoimmune thrombocytopenia (HP:0001973)2.71073823
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70809214
50Abnormality of polysaccharide metabolism (HP:0011012)2.70809214
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70809214
52Urinary glycosaminoglycan excretion (HP:0003541)2.70720628
53Mucopolysacchariduria (HP:0008155)2.70720628
54Abnormality of the vitamin B12 metabolism (HP:0004341)2.67635251
55Metaphyseal irregularity (HP:0003025)2.65685619
56Mutism (HP:0002300)2.63663087
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.62821175
58Broad metatarsal (HP:0001783)2.62324880
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59363333
60Short 4th metacarpal (HP:0010044)2.59363333
61Nephritis (HP:0000123)2.57948842
62Premature loss of primary teeth (HP:0006323)2.56055889
63Abnormal cartilage morphology (HP:0002763)2.54662816
64Esophageal varix (HP:0002040)2.53054685
65Decreased circulating renin level (HP:0003351)2.50262485
66Xanthomatosis (HP:0000991)2.49304420
67Mediastinal lymphadenopathy (HP:0100721)2.47452520
68Abnormality of vitamin B metabolism (HP:0004340)2.46802926
69Biliary tract neoplasm (HP:0100574)2.45033676
70Hypobetalipoproteinemia (HP:0003563)2.42172417
71Hyperparathyroidism (HP:0000843)2.41255800
72Palpitations (HP:0001962)2.40053490
73Myositis (HP:0100614)2.38926002
74Abnormality of chloride homeostasis (HP:0011422)2.37638931
75Hypophosphatemia (HP:0002148)2.37160087
76Myocardial infarction (HP:0001658)2.36712002
77Abnormal foot bone ossification (HP:0010675)2.36508695
78Optic neuritis (HP:0100653)2.36045480
79Retrobulbar optic neuritis (HP:0100654)2.36045480
80Alopecia of scalp (HP:0002293)2.34670338
81Metabolic alkalosis (HP:0200114)2.34658554
82Urethral obstruction (HP:0000796)2.32334861
83Hemorrhage of the eye (HP:0011885)2.31796408
84Neurofibrillary tangles (HP:0002185)2.29700264
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.28823844
86Hypolipoproteinemia (HP:0010981)2.27752154
87Hypoalphalipoproteinemia (HP:0003233)2.24877119
88Pulmonary infiltrates (HP:0002113)2.24129372
89Protuberant abdomen (HP:0001538)2.22989349
90Recurrent gram-negative bacterial infections (HP:0005420)2.21044898
91Bone pain (HP:0002653)2.19999349
92Amyloidosis (HP:0011034)2.14584062
93Hemoptysis (HP:0002105)2.13278862
94Spastic diplegia (HP:0001264)2.12898192
95Petechiae (HP:0000967)2.12280601
96Congenital sensorineural hearing impairment (HP:0008527)2.11904442
97Vasculitis (HP:0002633)2.11124187
98Abnormality of the gastric mucosa (HP:0004295)2.08882883
99Plantar hyperkeratosis (HP:0007556)2.08307221
100Micronodular cirrhosis (HP:0001413)2.06344034
101Onycholysis (HP:0001806)2.05693390
102Peripheral demyelination (HP:0011096)2.04779421
103Hydroureter (HP:0000072)2.04672480
104Mitral valve prolapse (HP:0001634)2.03480852
105Enlarged epiphyses (HP:0010580)2.02857677
106Wide cranial sutures (HP:0010537)2.02753847
107Abnormality of vitamin metabolism (HP:0100508)2.02104662
108Short hallux (HP:0010109)2.02023253
109Epidermoid cyst (HP:0200040)2.01041403
110Hypoglycemic coma (HP:0001325)2.00866326
111Confusion (HP:0001289)2.00541183
112Syncope (HP:0001279)2.00461143
113Abnormality of the 4th metacarpal (HP:0010012)1.99547969
114Woolly hair (HP:0002224)1.98202400
115Aneurysm (HP:0002617)1.97904388
116Abnormal tarsal ossification (HP:0008369)1.97405150
117Hydroxyprolinuria (HP:0003080)1.97250340
118Abnormality of proline metabolism (HP:0010907)1.97250340
119Hyperammonemia (HP:0001987)1.96399126
120Pustule (HP:0200039)1.96143798
121Cerebral aneurysm (HP:0004944)1.95089382
122Recurrent skin infections (HP:0001581)1.94933259
123Follicular hyperkeratosis (HP:0007502)1.93661265
124Abnormality of renin-angiotensin system (HP:0000847)1.93564724
125Abnormal ossification of hand bones (HP:0005921)1.93497499
126Abnormality of the nasal mucosa (HP:0000433)1.93076588
127Abnormality of the distal phalanges of the toes (HP:0010182)1.91950925
128Abnormality of small intestinal villus morphology (HP:0011472)1.91819016
129Villous atrophy (HP:0011473)1.91819016
130Chronic obstructive pulmonary disease (HP:0006510)1.91605818
131Obstructive lung disease (HP:0006536)1.91605818
132Ventricular tachycardia (HP:0004756)1.90748565
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90391124
134Abnormality of the 1st metacarpal (HP:0010009)1.89441562
135Alkalosis (HP:0001948)1.88948697
136Dilatation of the ascending aorta (HP:0005111)1.88684861
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88481189
138Fragile skin (HP:0001030)1.86936664
139Segmental peripheral demyelination/remyelination (HP:0003481)1.86822171
140Purpura (HP:0000979)1.86405533
141Peritonitis (HP:0002586)1.84862486
142Increased serum ferritin (HP:0003281)1.84487682
143Ventricular fibrillation (HP:0001663)1.84434045
144Ulnar bowing (HP:0003031)1.84304309
145Ureteral stenosis (HP:0000071)1.83402038
146Neoplasm of the rectum (HP:0100743)1.83383375
147Eczematoid dermatitis (HP:0000976)1.82637737
148Neonatal short-limb short stature (HP:0008921)1.82615554
149Apathy (HP:0000741)1.81930276
150Bone cyst (HP:0012062)1.81741568
151Abnormality of the costochondral junction (HP:0000919)1.81316297
152Dementia (HP:0000726)1.81297265
153Aplasia/Hypoplasia of the hallux (HP:0008362)1.79912983
154Gastrointestinal stroma tumor (HP:0100723)1.79586039
155Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.79215098
156Complement deficiency (HP:0004431)1.79190900
157Abnormality of the right ventricle (HP:0001707)1.79019584
158Aortic regurgitation (HP:0001659)1.78728065
159Stroke (HP:0001297)1.78020070
160Visceral angiomatosis (HP:0100761)1.77989059
161Diminished motivation (HP:0000745)1.76138410
162Microretrognathia (HP:0000308)1.75048285
163Pigmentary retinal degeneration (HP:0001146)1.74095785
164Hypotension (HP:0002615)1.73915461
165Spontaneous hematomas (HP:0007420)1.73787737
166Recurrent fungal infections (HP:0002841)1.73732280
167Pancreatitis (HP:0001733)1.73615519
168Hematochezia (HP:0002573)1.71968466
169Ureteral obstruction (HP:0006000)1.71545872
170Neoplasm of the small intestine (HP:0100833)1.71269232
171Fragile nails (HP:0001808)1.70613408
172Abnormality of carpal bone ossification (HP:0006257)1.69909900
173Type 1 muscle fiber predominance (HP:0003803)1.69345366
174Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68919375
175Progressive sensorineural hearing impairment (HP:0000408)1.68330066
176Acanthocytosis (HP:0001927)1.68091996
177Periodontitis (HP:0000704)1.67921845
178Hoarse voice (HP:0001609)1.67451758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.07298655
2LMTK25.87422874
3ACVR1B5.46995755
4RIPK14.27687906
5MYLK3.98807028
6IRAK33.27185578
7MST1R3.17205357
8MST43.12372350
9PRKG23.00909992
10TTN2.68715561
11TESK12.52115592
12BLK2.44379324
13PIK3CA2.29670630
14GRK72.09072505
15MAP2K22.05016428
16PRPF4B2.02826745
17PTK61.96438751
18MAP3K21.94992997
19MAP4K11.93521017
20EPHB21.66187659
21ERN11.63941307
22BMPR21.63613472
23NME21.63534575
24MAP3K111.62884768
25DMPK1.61157606
26IKBKE1.60152322
27LATS11.58465850
28MAP3K101.54472792
29IRAK41.52343053
30TAOK21.49888949
31TESK21.39273946
32GRK61.38906286
33FGR1.36683682
34JAK31.35344627
35CSF1R1.32779767
36MET1.32726582
37EPHA21.30779321
38EPHB11.28992071
39DDR21.27670896
40IKBKB1.24377251
41LIMK11.22824675
42NUAK11.22090204
43PAK21.16121319
44FGFR41.14147452
45ZAP701.11904748
46ERBB21.10274179
47FER1.10260116
48MAP3K141.09148664
49TXK1.09052844
50MAP3K31.04340061
51ABL21.02929329
52PDGFRA1.02325951
53ADRBK21.01655713
54MAP2K11.00175162
55TGFBR20.99741838
56PIM20.95721335
57SYK0.92371924
58PTK20.92359440
59LYN0.91449676
60IRAK10.89427578
61FGFR20.86464069
62CSK0.84081133
63ITK0.80874876
64KIT0.80617717
65STK100.79350720
66MAP2K60.79044175
67EEF2K0.77734986
68PKN20.77348497
69MAP3K120.77034790
70MATK0.76950961
71MAP3K70.76809489
72ERBB40.75427370
73PAK40.72591762
74PRKAA20.70293466
75SCYL20.67537453
76INSRR0.66567346
77PIK3CG0.66302581
78MAP3K130.66059590
79FGFR30.65888136
80PDGFRB0.65634065
81CAMK2G0.64392914
82LCK0.62497410
83TYK20.61952873
84MAP3K50.61228503
85STK240.60731305
86GRK10.60620320
87GSK3A0.59616147
88PDK10.59225013
89LRRK20.59157119
90EPHA30.58379149
91MAP2K30.56141545
92OXSR10.55005819
93CDK60.54931829
94CAMK2D0.54783292
95ROCK10.53913369
96MAPK110.53784910
97PDK20.53522802
98KSR20.53289230
99STK390.52831929
100STK30.52340524
101PAK30.51040697
102TBK10.50710218
103PIM10.50002688
104DYRK1B0.47923703
105IRAK20.47553704
106SIK10.47528229
107CAMKK20.45882734
108BTK0.45735294
109CAMK2B0.45449150
110HCK0.44615789
111TYRO30.44286472
112PRKAA10.43914582
113DAPK20.43907034
114CHUK0.43266822
115TRIB30.42192523
116MOS0.41836018
117NME10.41469964
118JAK20.39674446
119JAK10.38552612
120BMX0.38433373
121MAP3K10.37852717
122SRC0.37364669
123RPS6KC10.35985028
124RPS6KL10.35985028
125CDC42BPA0.35698186
126PRKCD0.34665047
127MAPK70.33764929
128RPS6KB20.32815246
129TRPM70.32057045
130MAPK150.31629583
131TNIK0.31093335
132MAP3K80.30795153
133KDR0.30710559
134PRKACG0.29665895
135ABL10.29413028
136FYN0.28697255
137MAPK40.28126256
138PAK10.27946360
139MAPKAPK20.25941688
140INSR0.25260263
141PRKCA0.23138963
142RIPK40.22528811
143FGFR10.22413450
144PRKG10.21439676
145TAOK10.20458594
146TAOK30.20451119
147PDPK10.20170110
148ALK0.19787322
149SGK30.19553784
150RPS6KA20.19317218

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.12053110
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.84360170
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.62621959
4Asthma_Homo sapiens_hsa053103.08681177
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.85658541
6Nitrogen metabolism_Homo sapiens_hsa009102.80640214
7Allograft rejection_Homo sapiens_hsa053302.75185540
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.69284336
9Bile secretion_Homo sapiens_hsa049762.60059588
10Other glycan degradation_Homo sapiens_hsa005112.50460440
11Graft-versus-host disease_Homo sapiens_hsa053322.45360139
12Histidine metabolism_Homo sapiens_hsa003402.43807058
13Autoimmune thyroid disease_Homo sapiens_hsa053202.38873369
14Mineral absorption_Homo sapiens_hsa049782.33538684
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.30627411
16Leishmaniasis_Homo sapiens_hsa051402.07689891
17Type I diabetes mellitus_Homo sapiens_hsa049401.97936639
18Fat digestion and absorption_Homo sapiens_hsa049751.91309805
19Tryptophan metabolism_Homo sapiens_hsa003801.89490371
20Rheumatoid arthritis_Homo sapiens_hsa053231.88027053
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78826435
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75264251
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70983416
24Fatty acid degradation_Homo sapiens_hsa000711.69895472
25Lysosome_Homo sapiens_hsa041421.68117485
26Caffeine metabolism_Homo sapiens_hsa002321.66990833
27Antigen processing and presentation_Homo sapiens_hsa046121.66984944
28Chemical carcinogenesis_Homo sapiens_hsa052041.66492791
29Starch and sucrose metabolism_Homo sapiens_hsa005001.65160742
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64712027
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.57294433
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56298149
33Tuberculosis_Homo sapiens_hsa051521.43540543
34Osteoclast differentiation_Homo sapiens_hsa043801.41485566
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41359430
36Arginine biosynthesis_Homo sapiens_hsa002201.37183846
37PPAR signaling pathway_Homo sapiens_hsa033201.35760937
38Butanoate metabolism_Homo sapiens_hsa006501.35551974
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31712691
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.25660280
41Viral myocarditis_Homo sapiens_hsa054161.21915877
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19856318
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.17055173
44Protein digestion and absorption_Homo sapiens_hsa049741.11513597
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10823998
46ABC transporters_Homo sapiens_hsa020101.10036624
47Glutathione metabolism_Homo sapiens_hsa004801.08624817
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.08189441
49Phenylalanine metabolism_Homo sapiens_hsa003601.05450318
50Phagosome_Homo sapiens_hsa041451.04154352
51Influenza A_Homo sapiens_hsa051641.03033981
52beta-Alanine metabolism_Homo sapiens_hsa004101.02979304
53Complement and coagulation cascades_Homo sapiens_hsa046101.02413978
54Galactose metabolism_Homo sapiens_hsa000521.01856066
55Hematopoietic cell lineage_Homo sapiens_hsa046400.99601839
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98964736
57Renin-angiotensin system_Homo sapiens_hsa046140.90698848
58Retinol metabolism_Homo sapiens_hsa008300.85937915
59Sphingolipid metabolism_Homo sapiens_hsa006000.85855436
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85314288
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.84700831
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84494760
63Linoleic acid metabolism_Homo sapiens_hsa005910.84225043
64Arginine and proline metabolism_Homo sapiens_hsa003300.82936482
65ECM-receptor interaction_Homo sapiens_hsa045120.82175743
66Arachidonic acid metabolism_Homo sapiens_hsa005900.81971950
67Adherens junction_Homo sapiens_hsa045200.81759293
68Fructose and mannose metabolism_Homo sapiens_hsa000510.81313065
69Tight junction_Homo sapiens_hsa045300.81147516
70Chemokine signaling pathway_Homo sapiens_hsa040620.80829993
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79639874
72African trypanosomiasis_Homo sapiens_hsa051430.79507113
73Staphylococcus aureus infection_Homo sapiens_hsa051500.78946939
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.78221236
75Amoebiasis_Homo sapiens_hsa051460.76865626
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76197202
77Fatty acid metabolism_Homo sapiens_hsa012120.75985462
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75976319
79Gastric acid secretion_Homo sapiens_hsa049710.75837726
80Legionellosis_Homo sapiens_hsa051340.75833551
81Propanoate metabolism_Homo sapiens_hsa006400.74157732
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72674204
83Pancreatic secretion_Homo sapiens_hsa049720.72223559
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72184341
85Ether lipid metabolism_Homo sapiens_hsa005650.70992856
86Prion diseases_Homo sapiens_hsa050200.68685415
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68094642
88Herpes simplex infection_Homo sapiens_hsa051680.65703727
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60949349
90Focal adhesion_Homo sapiens_hsa045100.60298139
91Thyroid hormone synthesis_Homo sapiens_hsa049180.57730594
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57623106
93Glycerolipid metabolism_Homo sapiens_hsa005610.57177380
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.56984707
95Insulin resistance_Homo sapiens_hsa049310.55140344
96Vitamin digestion and absorption_Homo sapiens_hsa049770.54333432
97Pyruvate metabolism_Homo sapiens_hsa006200.54292931
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53931725
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51560039
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50525207
101Lysine degradation_Homo sapiens_hsa003100.50232292
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50013017
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49257515
104B cell receptor signaling pathway_Homo sapiens_hsa046620.48347197
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46657202
106Carbon metabolism_Homo sapiens_hsa012000.46345691
107Salmonella infection_Homo sapiens_hsa051320.46275805
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.46180138
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44394278
110Tyrosine metabolism_Homo sapiens_hsa003500.43861137
111Peroxisome_Homo sapiens_hsa041460.43560781
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42893677
113Selenocompound metabolism_Homo sapiens_hsa004500.42743068
114Hepatitis C_Homo sapiens_hsa051600.42647883
115Toxoplasmosis_Homo sapiens_hsa051450.39067757
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38933830
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.38549951
118Platelet activation_Homo sapiens_hsa046110.35602887
119Small cell lung cancer_Homo sapiens_hsa052220.35160898
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34799156
121Salivary secretion_Homo sapiens_hsa049700.34721414
122TNF signaling pathway_Homo sapiens_hsa046680.33539428
123Pentose phosphate pathway_Homo sapiens_hsa000300.33444398
124Vibrio cholerae infection_Homo sapiens_hsa051100.32832207
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32612419
126Proteoglycans in cancer_Homo sapiens_hsa052050.32029071
127Apoptosis_Homo sapiens_hsa042100.31954755
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31598185
129Collecting duct acid secretion_Homo sapiens_hsa049660.31468028
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30455933
131Pertussis_Homo sapiens_hsa051330.30218468
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.30080201
133Systemic lupus erythematosus_Homo sapiens_hsa053220.29403644
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.29342314
135Shigellosis_Homo sapiens_hsa051310.29131602
136N-Glycan biosynthesis_Homo sapiens_hsa005100.28962977
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28861076
138Measles_Homo sapiens_hsa051620.28116550
139Bladder cancer_Homo sapiens_hsa052190.25914407
140Hepatitis B_Homo sapiens_hsa051610.25441880
141Primary immunodeficiency_Homo sapiens_hsa053400.24760636
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24439032
143Malaria_Homo sapiens_hsa051440.23678216
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.22735627
145Folate biosynthesis_Homo sapiens_hsa007900.22321854
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22076719

Most similar genes based on co-expression Upload to Enrichr

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