ADAMTS10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.48125824
2regulation of gamma-delta T cell differentiation (GO:0045586)4.55882368
3positive thymic T cell selection (GO:0045059)4.46245222
4negative regulation of cell killing (GO:0031342)4.42920063
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.42920063
6regulation of gamma-delta T cell activation (GO:0046643)4.34165340
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03006985
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03006985
9negative thymic T cell selection (GO:0045060)3.91082634
10negative T cell selection (GO:0043383)3.87119697
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79519131
12cell migration in hindbrain (GO:0021535)3.75648983
13peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.72638304
14thymic T cell selection (GO:0045061)3.70218491
15protein heterotrimerization (GO:0070208)3.64040626
16mannose metabolic process (GO:0006013)3.62396046
17positive T cell selection (GO:0043368)3.58721512
18antigen processing and presentation of endogenous antigen (GO:0019883)3.52937939
19blood vessel maturation (GO:0001955)3.51169255
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.47271169
21semaphorin-plexin signaling pathway (GO:0071526)3.47221372
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44233051
23regulation of ARF GTPase activity (GO:0032312)3.33659864
24negative regulation of erythrocyte differentiation (GO:0045647)3.26846315
25T cell selection (GO:0045058)3.24387292
26negative regulation of stress fiber assembly (GO:0051497)3.20575771
27histone H3-K4 trimethylation (GO:0080182)3.18055179
28morphogenesis of an endothelium (GO:0003159)3.17792102
29endothelial tube morphogenesis (GO:0061154)3.17792102
30antigen processing and presentation via MHC class Ib (GO:0002475)3.11142015
31cell-cell junction maintenance (GO:0045217)3.11066370
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10070232
33regulation of ARF protein signal transduction (GO:0032012)3.06706053
34regulation of B cell receptor signaling pathway (GO:0050855)3.03803717
35dermatan sulfate metabolic process (GO:0030205)3.03022345
36regulation of T cell tolerance induction (GO:0002664)3.02658284
37vascular endothelial growth factor signaling pathway (GO:0038084)3.00918315
38negative regulation of catenin import into nucleus (GO:0035414)3.00631774
39positive regulation of histone deacetylation (GO:0031065)2.99086583
40interferon-gamma production (GO:0032609)2.88655899
41response to interleukin-15 (GO:0070672)2.87380760
42substrate-dependent cell migration (GO:0006929)2.86702100
43positive regulation of protein kinase C signaling (GO:0090037)2.85876498
44definitive hemopoiesis (GO:0060216)2.85428384
45regulation of B cell differentiation (GO:0045577)2.81653063
46cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.80960086
47negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.79995573
48positive regulation of Rap GTPase activity (GO:0032854)2.74716102
49chondroitin sulfate catabolic process (GO:0030207)2.74328908
50positive regulation of tolerance induction (GO:0002645)2.73953343
51negative regulation of granulocyte differentiation (GO:0030853)2.71893636
52positive regulation of B cell differentiation (GO:0045579)2.69551105
53dendritic spine morphogenesis (GO:0060997)2.68167968
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64299871
55histone H3 deacetylation (GO:0070932)2.63496159
56positive regulation of CREB transcription factor activity (GO:0032793)2.61784074
57axon extension (GO:0048675)2.61532876
58response to muramyl dipeptide (GO:0032495)2.60861849
59regulation of synapse structural plasticity (GO:0051823)2.59254583
60urinary tract smooth muscle contraction (GO:0014848)2.58712409
61neuronal ion channel clustering (GO:0045161)2.56152977
62negative regulation of phagocytosis (GO:0050765)2.55071700
63insulin-like growth factor receptor signaling pathway (GO:0048009)2.54704648
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54399194
65T cell migration (GO:0072678)2.54379183
66planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53342098
67natural killer cell differentiation (GO:0001779)2.51721532
68regulation of extracellular matrix disassembly (GO:0010715)2.50460908
69negative regulation of interleukin-12 production (GO:0032695)2.49657381
70cAMP biosynthetic process (GO:0006171)2.49135518
71camera-type eye morphogenesis (GO:0048593)2.48673073
72positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47628577
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.46955862
74cell proliferation involved in metanephros development (GO:0072203)2.46730381
75positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.46481017
76B cell receptor signaling pathway (GO:0050853)2.46463188
77atrioventricular valve morphogenesis (GO:0003181)2.45434189
78negative regulation of Ras protein signal transduction (GO:0046580)2.45323600
79histone H4 deacetylation (GO:0070933)2.45196118
80regulation of granulocyte differentiation (GO:0030852)2.44923512
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.44471531
82positive regulation of granulocyte differentiation (GO:0030854)2.44306219
83oxygen transport (GO:0015671)2.42368915
84activation of protein kinase A activity (GO:0034199)2.41904433
85response to fluid shear stress (GO:0034405)2.41737611
86negative regulation of actin filament bundle assembly (GO:0032232)2.41363034
87negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.40336690
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.40118523
89regulation of regulatory T cell differentiation (GO:0045589)2.39625818
90negative regulation of small GTPase mediated signal transduction (GO:0051058)2.39507767
91head development (GO:0060322)2.39368358
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.39168268
93regulation of Rap GTPase activity (GO:0032317)2.38255558
94regulation of synapse maturation (GO:0090128)2.38225526
95embryonic hemopoiesis (GO:0035162)2.37242231
96angiogenesis involved in wound healing (GO:0060055)2.36584724
97cardiac myofibril assembly (GO:0055003)2.35979574
98histone H3-K4 methylation (GO:0051568)2.35763902
99neuron projection extension involved in neuron projection guidance (GO:1902284)2.35422122
100axon extension involved in axon guidance (GO:0048846)2.35422122
101barbed-end actin filament capping (GO:0051016)2.35024071
102synaptic vesicle docking involved in exocytosis (GO:0016081)2.34738192
103sodium ion export (GO:0071436)2.34423374
104adenosine receptor signaling pathway (GO:0001973)2.34002977
105cell junction maintenance (GO:0034331)2.33351652
106T cell receptor signaling pathway (GO:0050852)2.32498723
107regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.32237812
108regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.32079072
109T cell homeostasis (GO:0043029)2.31296297
110peptidyl-lysine dimethylation (GO:0018027)2.30772560
111fibroblast migration (GO:0010761)2.30664908
112activation of JUN kinase activity (GO:0007257)2.30548073
113leukocyte aggregation (GO:0070486)2.30242945
114regulation of hydrogen peroxide metabolic process (GO:0010310)2.29417291
115secretory granule organization (GO:0033363)2.27989812
116response to laminar fluid shear stress (GO:0034616)2.27246130
117glomerular filtration (GO:0003094)2.27245328
118megakaryocyte development (GO:0035855)2.27219195
119positive regulation of protein deacetylation (GO:0090312)2.26922416
120endothelial cell chemotaxis (GO:0035767)2.25961488
121establishment of mitochondrion localization (GO:0051654)2.25266913
122neuron projection extension (GO:1990138)2.25013298
123endodermal cell differentiation (GO:0035987)2.24776849
124cellular response to monoamine stimulus (GO:0071868)2.24351014
125cellular response to catecholamine stimulus (GO:0071870)2.24351014
126collagen fibril organization (GO:0030199)2.23909686
127cell migration involved in heart development (GO:0060973)2.23819861
128dermatan sulfate biosynthetic process (GO:0030208)2.23645403
129cellular response to zinc ion (GO:0071294)2.23617506
130antigen receptor-mediated signaling pathway (GO:0050851)2.21843962
131negative regulation of glial cell proliferation (GO:0060253)2.21767225
132regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20862037
133activated T cell proliferation (GO:0050798)2.20201278
134lymphocyte homeostasis (GO:0002260)2.19947414
135bone trabecula formation (GO:0060346)2.19887999
136T cell costimulation (GO:0031295)2.19887830
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.19601795
138positive regulation of lamellipodium organization (GO:1902745)2.19094745
139apoptotic cell clearance (GO:0043277)2.18990695
140venous blood vessel morphogenesis (GO:0048845)2.18948281
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.17961108
142sequestering of extracellular ligand from receptor (GO:0035581)2.17862311
143regulation of tolerance induction (GO:0002643)2.17288282
144adherens junction assembly (GO:0034333)2.17217184
145regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.16042542
146pyrimidine nucleobase catabolic process (GO:0006208)2.15830513
147lymphocyte costimulation (GO:0031294)2.15447741
148heart morphogenesis (GO:0003007)2.15257495
149negative regulation of axonogenesis (GO:0050771)2.14309774
150leukocyte cell-cell adhesion (GO:0007159)2.14281873
151regulation of isotype switching to IgG isotypes (GO:0048302)2.14276083
152negative regulation of glycoprotein biosynthetic process (GO:0010561)2.13563801
153positive regulation of natural killer cell differentiation (GO:0032825)2.13512145
154regulation of glycogen (starch) synthase activity (GO:2000465)2.13171495
155locomotory exploration behavior (GO:0035641)2.13122168
156establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.13088584
157mitochondrion transport along microtubule (GO:0047497)2.13088584
158basement membrane organization (GO:0071711)2.12887791
159cortical actin cytoskeleton organization (GO:0030866)2.09896234
160glucocorticoid receptor signaling pathway (GO:0042921)2.09573222
161stress fiber assembly (GO:0043149)2.09024048
162positive regulation of synapse maturation (GO:0090129)2.06223260
163cerebellar Purkinje cell differentiation (GO:0021702)2.00934510
164vocalization behavior (GO:0071625)2.00546473
165positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.00425012
166regulation of axon extension involved in axon guidance (GO:0048841)2.00004885
167establishment of nucleus localization (GO:0040023)1.99724285
168positive regulation of cholesterol efflux (GO:0010875)1.99586513
169extracellular matrix assembly (GO:0085029)1.98307347
170negative regulation of myotube differentiation (GO:0010832)1.97984048
171peripheral nervous system axon ensheathment (GO:0032292)1.97607770
172myelination in peripheral nervous system (GO:0022011)1.97607770
173postsynaptic membrane organization (GO:0001941)1.97542731
174protein targeting to plasma membrane (GO:0072661)1.96983553
175regulation of monocyte differentiation (GO:0045655)1.96835269

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.66114625
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.27685679
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.73584489
4MYC_22102868_ChIP-Seq_BL_Human3.63739340
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.35789081
6VDR_21846776_ChIP-Seq_THP-1_Human3.10482848
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.86442616
8EZH2_22144423_ChIP-Seq_EOC_Human2.77408978
9SCL_19346495_ChIP-Seq_HPC-7_Human2.73266187
10TCF7_22412390_ChIP-Seq_EML_Mouse2.73222989
11RUNX_20019798_ChIP-Seq_JUKART_Human2.59821242
12KDM2B_26808549_Chip-Seq_DND41_Human2.59437074
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.54953777
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48674424
15MAF_26560356_Chip-Seq_TH1_Human2.48633030
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.48348222
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42573037
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.39600633
19UTX_26944678_Chip-Seq_JUKART_Human2.38681987
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.26186780
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20360074
22VDR_24763502_ChIP-Seq_THP-1_Human2.20256230
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06562385
24E2F7_22180533_ChIP-Seq_HELA_Human2.05406708
25SPI1_23127762_ChIP-Seq_K562_Human1.99538250
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.97543114
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97539775
28KDM2B_26808549_Chip-Seq_JURKAT_Human1.97014398
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96490862
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95470948
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95317783
32MYB_26560356_Chip-Seq_TH2_Human1.91464951
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90211611
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.89590506
35* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88958016
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.83689085
37* CTCF_27219007_Chip-Seq_Bcells_Human1.83513153
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83070351
39MYB_26560356_Chip-Seq_TH1_Human1.81090201
40CIITA_25753668_ChIP-Seq_RAJI_Human1.79596194
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.76754601
42GATA1_22025678_ChIP-Seq_K562_Human1.76326887
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75144020
44* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74986817
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.73224177
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.71128721
47CLOCK_20551151_ChIP-Seq_293T_Human1.70705311
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69725854
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68186232
50LXR_22292898_ChIP-Seq_THP-1_Human1.67863652
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67173411
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66853352
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66853352
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66552439
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63336346
56P68_20966046_ChIP-Seq_HELA_Human1.62637699
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60856938
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60775690
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60745770
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60617668
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58367229
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57789635
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56752939
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55524005
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55164230
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55144641
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.53467626
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.53427206
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51919498
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50732475
71MAF_26560356_Chip-Seq_TH2_Human1.49551666
72* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49341180
73* SA1_27219007_Chip-Seq_ERYTHROID_Human1.48894594
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48539955
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.48088830
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47976173
77SMC4_20622854_ChIP-Seq_HELA_Human1.45846409
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44700957
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38863883
80DROSHA_22980978_ChIP-Seq_HELA_Human1.38048335
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.34593535
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34123264
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33358801
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33032089
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32437134
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30898309
87* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29660826
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.28758867
89KDM2B_26808549_Chip-Seq_K562_Human1.28600111
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27983514
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.27662986
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.26850373
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.25963069
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25475405
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25098697
96CREB1_26743006_Chip-Seq_LNCaP_Human1.24921663
97NCOR1_26117541_ChIP-Seq_K562_Human1.24485557
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23924318
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23782572
100GATA1_19941826_ChIP-Seq_K562_Human1.23464418
101* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22273911
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21459606
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20545062
104* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20543694
105GATA3_27048872_Chip-Seq_THYMUS_Human1.20089620
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19926659
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.18659403
108TBX20_22080862_ChIP-Seq_HEART_Mouse1.18659403
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.17651554
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17537170
111SPI1_23547873_ChIP-Seq_NB4_Human1.16616946
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15341423
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14878937
114RING1B_27294783_Chip-Seq_ESCs_Mouse1.14482037
115SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13108114
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12534477
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12524442
118TRIM28_21343339_ChIP-Seq_HEK293_Human1.12281377
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10559237
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10061879
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09895535
122* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09556718
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08530344
124OCT4_19829295_ChIP-Seq_ESCs_Human1.07741357
125SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07212563
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06659021
127BCL6_27268052_Chip-Seq_Bcells_Human1.06374738
128TP53_20018659_ChIP-ChIP_R1E_Mouse1.05450441
129ELF1_20517297_ChIP-Seq_JURKAT_Human1.05097809
130TP53_23651856_ChIP-Seq_MEFs_Mouse1.04304612
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04203494
132TP53_22127205_ChIP-Seq_IMR90_Human1.03573868
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03510243
134TET1_21490601_ChIP-Seq_MESCs_Mouse1.02765320
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02339310
136NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01923365
137RACK7_27058665_Chip-Seq_MCF-7_Human1.01553104
138* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00823048
139TP63_22573176_ChIP-Seq_HFKS_Human1.00755791
140SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00374497
141SMAD_19615063_ChIP-ChIP_OVARY_Human1.00152269
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00029844
143KLF4_19829295_ChIP-Seq_ESCs_Human0.98594989
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98393132
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98189671
146RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97825319
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97445099
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.97156553
149BCOR_27268052_Chip-Seq_Bcells_Human0.95076279
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94263498
151* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91620183
152GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91599672
153NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88773346
154CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87862944
155NOTCH1_21737748_ChIP-Seq_TLL_Human0.87570387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.19372453
2MP0001958_emphysema3.09399353
3MP0004859_abnormal_synaptic_plasticity3.06851961
4MP0005503_abnormal_tendon_morphology3.01516516
5MP0005275_abnormal_skin_tensile2.66396161
6MP0002396_abnormal_hematopoietic_system2.65350383
7MP0003279_aneurysm2.64281308
8MP0010368_abnormal_lymphatic_system2.42442560
9MP0000569_abnormal_digit_pigmentation2.35206170
10MP0002166_altered_tumor_susceptibility2.34769567
11MP0003763_abnormal_thymus_physiology2.32739637
12MP0000685_abnormal_immune_system2.24889859
13MP0003705_abnormal_hypodermis_morpholog2.22329338
14MP0009278_abnormal_bone_marrow2.18169374
15MP0001348_abnormal_lacrimal_gland2.16439361
16MP0004808_abnormal_hematopoietic_stem2.14711913
17MP0005409_darkened_coat_color2.10260591
18MP0001879_abnormal_lymphatic_vessel2.03881018
19MP0006054_spinal_hemorrhage2.01631401
20MP0005423_abnormal_somatic_nervous1.82431838
21MP0004510_myositis1.82261639
22MP0000751_myopathy1.77423939
23MP0005671_abnormal_response_to1.77385956
24MP0001835_abnormal_antigen_presentation1.73328931
25MP0004858_abnormal_nervous_system1.71055150
26MP0003172_abnormal_lysosome_physiology1.69815437
27MP0004272_abnormal_basement_membrane1.67706198
28MP0002006_tumorigenesis1.67031339
29MP0003300_gastrointestinal_ulcer1.66891627
30MP0002249_abnormal_larynx_morphology1.63894631
31MP0001849_ear_inflammation1.63207868
32MP0001790_abnormal_immune_system1.61582831
33MP0005387_immune_system_phenotype1.61582831
34MP0003690_abnormal_glial_cell1.60419737
35MP0003566_abnormal_cell_adhesion1.59508806
36MP0001502_abnormal_circadian_rhythm1.58187725
37MP0004084_abnormal_cardiac_muscle1.55729091
38MP0001800_abnormal_humoral_immune1.54789279
39MP0002932_abnormal_joint_morphology1.53965874
40MP0000703_abnormal_thymus_morphology1.51968383
41MP0002398_abnormal_bone_marrow1.51402144
42MP0000013_abnormal_adipose_tissue1.51075229
43MP0000778_abnormal_nervous_system1.49278868
44MP0000767_abnormal_smooth_muscle1.49059064
45MP0003828_pulmonary_edema1.46408771
46MP0003045_fibrosis1.45691319
47MP0000003_abnormal_adipose_tissue1.45405818
48MP0000733_abnormal_muscle_development1.44321683
49MP0005397_hematopoietic_system_phenotyp1.43457974
50MP0001545_abnormal_hematopoietic_system1.43457974
51MP0002933_joint_inflammation1.41506167
52MP0003635_abnormal_synaptic_transmissio1.41285304
53MP0002420_abnormal_adaptive_immunity1.39462974
54MP0003329_amyloid_beta_deposits1.39093724
55MP0003879_abnormal_hair_cell1.37242768
56MP0001819_abnormal_immune_cell1.36598866
57MP0001873_stomach_inflammation1.36235278
58MP0003091_abnormal_cell_migration1.36005014
59MP0002452_abnormal_antigen_presenting1.33617422
60MP0005377_hearing/vestibular/ear_phenot1.32791754
61MP0003878_abnormal_ear_physiology1.32791754
62MP0005023_abnormal_wound_healing1.29380650
63MP0005375_adipose_tissue_phenotype1.29012741
64MP0003115_abnormal_respiratory_system1.25722142
65MP0000716_abnormal_immune_system1.23443823
66MP0002405_respiratory_system_inflammati1.22670404
67MP0010630_abnormal_cardiac_muscle1.21378208
68MP0002722_abnormal_immune_system1.21235270
69MP0002063_abnormal_learning/memory/cond1.20595254
70MP0002723_abnormal_immune_serum1.20561563
71MP0005464_abnormal_platelet_physiology1.16949190
72MP0000465_gastrointestinal_hemorrhage1.16692144
73MP0005058_abnormal_lysosome_morphology1.14613525
74MP0000689_abnormal_spleen_morphology1.14327947
75MP0005000_abnormal_immune_tolerance1.13978484
76MP0003436_decreased_susceptibility_to1.10693013
77MP0002089_abnormal_postnatal_growth/wei1.10495876
78MP0002925_abnormal_cardiovascular_devel1.10342015
79MP0005076_abnormal_cell_differentiation1.09426182
80MP0003303_peritoneal_inflammation1.08776691
81MP0008775_abnormal_heart_ventricle1.07816998
82MP0008961_abnormal_basal_metabolism1.07297572
83MP0001986_abnormal_taste_sensitivity1.07229760
84MP0010155_abnormal_intestine_physiology1.06817294
85MP0002429_abnormal_blood_cell1.06421907
86MP0003866_abnormal_defecation1.05733104
87MP0004145_abnormal_muscle_electrophysio1.05640456
88MP0005025_abnormal_response_to1.05327168
89MP0002998_abnormal_bone_remodeling1.04964414
90MP0008260_abnormal_autophagy1.04237477
91MP0002128_abnormal_blood_circulation1.03187618
92MP0010030_abnormal_orbit_morphology1.03162787
93MP0004883_abnormal_blood_vessel1.02153947
94MP0000049_abnormal_middle_ear1.01793513
95MP0003567_abnormal_fetal_cardiomyocyte1.01767823
96MP0003448_altered_tumor_morphology1.00683980
97MP0002419_abnormal_innate_immunity0.99506962
98MP0002108_abnormal_muscle_morphology0.98398395
99MP0004087_abnormal_muscle_fiber0.98273339
100MP0005167_abnormal_blood-brain_barrier0.97231004
101MP0008569_lethality_at_weaning0.97152397
102MP0005174_abnormal_tail_pigmentation0.95305984
103MP0005595_abnormal_vascular_smooth0.94261402
104MP0005508_abnormal_skeleton_morphology0.94007097
105MP0005666_abnormal_adipose_tissue0.93515949
106MP0005385_cardiovascular_system_phenoty0.92874479
107MP0001544_abnormal_cardiovascular_syste0.92874479
108MP0009333_abnormal_splenocyte_physiolog0.92674672
109MP0000266_abnormal_heart_morphology0.92148683
110MP0001188_hyperpigmentation0.92105223
111MP0002116_abnormal_craniofacial_bone0.91861304
112MP0001175_abnormal_lung_morphology0.91815921
113MP0003385_abnormal_body_wall0.91708486
114MP0000858_altered_metastatic_potential0.91015425
115MP0003948_abnormal_gas_homeostasis0.90425219
116MP0002133_abnormal_respiratory_system0.90119388
117MP0005388_respiratory_system_phenotype0.90119388
118MP0001614_abnormal_blood_vessel0.89515642
119MP0002653_abnormal_ependyma_morphology0.89059573
120MP0003724_increased_susceptibility_to0.88843072
121MP0005623_abnormal_meninges_morphology0.87505806
122MP0001299_abnormal_eye_distance/0.87421270
123MP0004947_skin_inflammation0.86900716
124MP0000343_altered_response_to0.86486534
125MP0002822_catalepsy0.85617669
126MP0001533_abnormal_skeleton_physiology0.85353678
127MP0009785_altered_susceptibility_to0.83912497
128MP0005390_skeleton_phenotype0.82889476
129MP0000249_abnormal_blood_vessel0.82733138
130MP0004130_abnormal_muscle_cell0.81494583
131MP0002572_abnormal_emotion/affect_behav0.80593990
132MP0006138_congestive_heart_failure0.80550220
133MP0010352_gastrointestinal_tract_polyps0.77766012
134MP0000759_abnormal_skeletal_muscle0.76271836
135MP0001270_distended_abdomen0.75977800
136MP0002060_abnormal_skin_morphology0.75772839
137MP0000750_abnormal_muscle_regeneration0.73984301
138MP0009384_cardiac_valve_regurgitation0.73675914
139MP0003122_maternal_imprinting0.72891319
140MP0001853_heart_inflammation0.72833181
141MP0005670_abnormal_white_adipose0.72138088
142MP0005257_abnormal_intraocular_pressure0.71779867
143MP0001970_abnormal_pain_threshold0.71460622
144MP0000604_amyloidosis0.69675417
145MP0002295_abnormal_pulmonary_circulatio0.69462203
146MP0000428_abnormal_craniofacial_morphol0.67725025
147MP0002896_abnormal_bone_mineralization0.65913964
148MP0003634_abnormal_glial_cell0.65735634
149MP0002138_abnormal_hepatobiliary_system0.64979049
150MP0002113_abnormal_skeleton_development0.64501351
151MP0002882_abnormal_neuron_morphology0.64175639
152MP0000955_abnormal_spinal_cord0.63363541
153MP0000163_abnormal_cartilage_morphology0.62879397
154MP0002971_abnormal_brown_adipose0.61634910
155MP0004381_abnormal_hair_follicle0.61623415
156MP0004270_analgesia0.61474417
157MP0003787_abnormal_imprinting0.59733431
158MP0000026_abnormal_inner_ear0.59610247

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.01544315
2Protrusio acetabuli (HP:0003179)4.19101958
3Cerebral aneurysm (HP:0004944)4.17800330
4Aortic aneurysm (HP:0004942)3.86248164
5Short 4th metacarpal (HP:0010044)3.69522142
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.69522142
7Ankle contracture (HP:0006466)3.67360228
8* Broad metatarsal (HP:0001783)3.45239245
9Hyperacusis (HP:0010780)3.39390188
10Aortic dissection (HP:0002647)3.37063592
11Abnormality of the fingertips (HP:0001211)3.19558928
12Lymphangioma (HP:0100764)3.13085457
13Bladder diverticulum (HP:0000015)3.11306035
14Elevated erythrocyte sedimentation rate (HP:0003565)3.09111536
15Abnormality of the 4th metacarpal (HP:0010012)3.03456896
16Cervical subluxation (HP:0003308)3.00469777
17Turricephaly (HP:0000262)2.97211378
18Dilatation of the ascending aorta (HP:0005111)2.86701526
19Mitral valve prolapse (HP:0001634)2.83262510
20* Shallow orbits (HP:0000586)2.81045978
21Hematochezia (HP:0002573)2.76636954
22Annular pancreas (HP:0001734)2.73514125
23Bowel diverticulosis (HP:0005222)2.71331933
24Biconcave vertebral bodies (HP:0004586)2.69076781
25Papilledema (HP:0001085)2.66650466
26Myositis (HP:0100614)2.63126352
27Round ear (HP:0100830)2.62080348
28Spontaneous hematomas (HP:0007420)2.60479618
29Flat cornea (HP:0007720)2.59943747
30Premature rupture of membranes (HP:0001788)2.57549950
31Long toe (HP:0010511)2.55655740
32Elfin facies (HP:0004428)2.55486858
33Renovascular hypertension (HP:0100817)2.53340144
34Abnormality of the nasal mucosa (HP:0000433)2.49576229
35Sleep apnea (HP:0010535)2.45162900
36Renal duplication (HP:0000075)2.43901932
37Vitreoretinal degeneration (HP:0000655)2.39450262
38Arterial tortuosity (HP:0005116)2.34153488
39* Joint stiffness (HP:0001387)2.31190251
40Overgrowth (HP:0001548)2.29185946
41Syringomyelia (HP:0003396)2.28459503
42Spinal cord lesions (HP:0100561)2.28459503
43Absent frontal sinuses (HP:0002688)2.27436645
44Peritonitis (HP:0002586)2.27184461
45Pulmonary artery stenosis (HP:0004415)2.26944027
46Spondylolisthesis (HP:0003302)2.26840747
47Trigonocephaly (HP:0000243)2.26682993
48Aneurysm (HP:0002617)2.25799137
49Increased density of long bones (HP:0006392)2.24387950
50Wide anterior fontanel (HP:0000260)2.22877192
51Bicuspid aortic valve (HP:0001647)2.22798604
52Neoplasm of the heart (HP:0100544)2.22699270
53Radial bowing (HP:0002986)2.21832817
54Abnormality of the peritoneum (HP:0002585)2.19878720
55Thin ribs (HP:0000883)2.19400437
56Camptodactyly of toe (HP:0001836)2.16765172
57Supranuclear gaze palsy (HP:0000605)2.16663034
58Fragile skin (HP:0001030)2.16414488
59J-shaped sella turcica (HP:0002680)2.15811320
60Emphysema (HP:0002097)2.15511925
61Type 1 muscle fiber predominance (HP:0003803)2.14322953
62Dislocated radial head (HP:0003083)2.12951263
63Hemiplegia (HP:0002301)2.12003282
64Wrist flexion contracture (HP:0001239)2.11696165
65Striae distensae (HP:0001065)2.10078429
66Disproportionate tall stature (HP:0001519)2.08642146
67Long eyelashes (HP:0000527)2.07339115
68Increased connective tissue (HP:0009025)2.06841276
69Bronchomalacia (HP:0002780)2.05955264
70Mesomelia (HP:0003027)2.03403113
71Mild short stature (HP:0003502)2.02629747
72Infantile muscular hypotonia (HP:0008947)2.00614240
73Abnormality of the radial head (HP:0003995)2.00177354
74* Narrow palate (HP:0000189)2.00118902
75Chronic otitis media (HP:0000389)1.99755508
76Atrophic scars (HP:0001075)1.99533529
77Abnormality of the aortic arch (HP:0012303)1.98310627
78Overriding aorta (HP:0002623)1.97105815
79Wormian bones (HP:0002645)1.96969595
80Vertebral arch anomaly (HP:0008438)1.96360501
81* Mitral regurgitation (HP:0001653)1.96311189
82Increased variability in muscle fiber diameter (HP:0003557)1.96296328
83Persistence of primary teeth (HP:0006335)1.96145520
84Pointed chin (HP:0000307)1.94463450
85Rib fusion (HP:0000902)1.93466950
86Recurrent bronchitis (HP:0002837)1.93429901
87Hypoventilation (HP:0002791)1.92922726
88Ulnar bowing (HP:0003031)1.92776029
89Eczematoid dermatitis (HP:0000976)1.92446108
90Slender build (HP:0001533)1.90972099
91Abnormality of skeletal muscle fiber size (HP:0012084)1.90181337
92Flexion contracture of toe (HP:0005830)1.90018679
93Joint contractures involving the joints of the feet (HP:0100492)1.90018679
94Genu recurvatum (HP:0002816)1.90005840
95Neurofibrillary tangles (HP:0002185)1.89843743
96T lymphocytopenia (HP:0005403)1.88830646
97Systemic lupus erythematosus (HP:0002725)1.88430888
98Joint laxity (HP:0001388)1.87807812
99Vascular tortuosity (HP:0004948)1.87151720
100Prolonged bleeding time (HP:0003010)1.86853714
101Bowing of the arm (HP:0006488)1.85935846
102Bowed forearm bones (HP:0003956)1.85935846
103Supernumerary ribs (HP:0005815)1.84781473
104Hyperextensible skin (HP:0000974)1.84168156
105Metaphyseal cupping (HP:0003021)1.82867628
106Hemorrhage of the eye (HP:0011885)1.82819106
107* Ectopia lentis (HP:0001083)1.81948411
108Complement deficiency (HP:0004431)1.81110220
109Macroorchidism (HP:0000053)1.80653708
110IgM deficiency (HP:0002850)1.80359940
111Midline defect of the nose (HP:0004122)1.79799709
112Venous insufficiency (HP:0005293)1.78809700
113Frequent falls (HP:0002359)1.78698177
114Aortic regurgitation (HP:0001659)1.78639241
115Orchitis (HP:0100796)1.77904292
116Blue sclerae (HP:0000592)1.77735015
117Soft skin (HP:0000977)1.76743182
118Rectal prolapse (HP:0002035)1.76191707
119Deviation of the hallux (HP:0010051)1.75584044
120High pitched voice (HP:0001620)1.75332309
121* Spinal canal stenosis (HP:0003416)1.73608962
122Follicular hyperkeratosis (HP:0007502)1.73472534
123Broad face (HP:0000283)1.73392142
124Abnormality of T cell number (HP:0011839)1.73060927
125Long palpebral fissure (HP:0000637)1.72883567
126Nasal polyposis (HP:0100582)1.72070889
127Panhypogammaglobulinemia (HP:0003139)1.72053839
128Onion bulb formation (HP:0003383)1.71732999
129Chest pain (HP:0100749)1.71617121
130Thrombocytosis (HP:0001894)1.71470419
131Atelectasis (HP:0100750)1.71047341
132Sacral dimple (HP:0000960)1.70566469
133Hallux valgus (HP:0001822)1.69944137
134Stridor (HP:0010307)1.69915993
135Arterial thrombosis (HP:0004420)1.68717842
136Narrow nasal bridge (HP:0000446)1.68300145
137Mucopolysacchariduria (HP:0008155)1.67798081
138Urinary glycosaminoglycan excretion (HP:0003541)1.67798081
139Ulnar deviation of the wrist (HP:0003049)1.67727225
140Subacute progressive viral hepatitis (HP:0006572)1.67604883
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66821005
142Abnormality of polysaccharide metabolism (HP:0011012)1.66821005
143Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66821005
144Neonatal short-limb short stature (HP:0008921)1.66814392
145Difficulty running (HP:0009046)1.66561750
146Enlarged penis (HP:0000040)1.65780390
147Upper limb amyotrophy (HP:0009129)1.65265174
148Distal upper limb amyotrophy (HP:0007149)1.65265174
149Cellulitis (HP:0100658)1.63953446
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.63792571
151Recurrent fungal infections (HP:0002841)1.63668995
152Gastrointestinal inflammation (HP:0004386)1.63479846
153Gastrointestinal infarctions (HP:0005244)1.62844415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.39232113
2MAP4K13.34159841
3TRIB33.05894525
4RIPK12.95622769
5TGFBR22.72443566
6PRPF4B2.60935634
7EEF2K2.55270807
8PKN22.54712793
9TIE12.23132236
10KIT2.16826709
11CAMK1G2.07099767
12JAK31.99772799
13MAP3K101.99137067
14TNK21.96661370
15SIK21.96363185
16ZAP701.94509815
17PTK61.84811268
18MARK11.84315080
19SIK11.80785667
20CAMK1D1.75122800
21MAP2K31.69982259
22TYK21.69684566
23ITK1.67255941
24PDGFRA1.67169297
25MAPK151.66531643
26FGFR41.61275396
27TGFBR11.59203366
28JAK11.51486169
29TXK1.49778052
30NTRK31.47653436
31MAP3K61.46221107
32MAP3K71.41269578
33NTRK21.36609135
34STK101.36163662
35DMPK1.34826106
36MAPK71.34669834
37LRRK21.34143406
38BTK1.31557769
39PRKCH1.24259500
40CSF1R1.23103367
41KDR1.22251551
42CDK121.21306593
43FGFR31.19695441
44IKBKE1.16700170
45ICK1.15985104
46MYLK1.15528257
47PRKD31.14286818
48FLT31.13452821
49TEC1.11686093
50EPHA31.09536699
51SIK31.07944779
52PDGFRB1.05017097
53ERN11.03452523
54NTRK11.03204173
55HCK1.01636358
56NEK20.98831183
57LCK0.97951530
58TBK10.97113645
59CAMKK20.96667908
60EPHB10.95694751
61PAK40.95448480
62MAP3K110.93424452
63ACVR1B0.92711452
64MARK20.88581286
65BMX0.88511375
66CSK0.87990972
67PAK20.86468086
68TAOK10.86247242
69CAMK40.81008767
70CLK10.77460951
71SGK4940.77138441
72SGK2230.77138441
73MTOR0.74145388
74EPHB20.73980508
75BLK0.72856885
76CAMKK10.70866857
77SGK30.70009748
78CDK60.69164551
79CAMK10.67872754
80STK110.67307624
81ERBB20.66926339
82DDR20.66854573
83FGFR20.66448009
84PRKD20.66202312
85UHMK10.64941495
86CHUK0.64334358
87RPS6KA40.61632892
88RET0.61092585
89JAK20.61006751
90PTK20.60992703
91FES0.60519726
92DAPK20.59623877
93PRKD10.58764190
94MARK30.58628466
95SYK0.58015627
96ILK0.57164032
97MAPK40.55856533
98PIM10.55238586
99PAK60.54903654
100RPS6KA60.54741407
101FYN0.54372804
102GRK60.54147628
103SGK20.53331024
104MAPK80.53222612
105CDK40.53176132
106CDK50.51770851
107TESK10.50123159
108PKN10.50000805
109RPS6KL10.49380885
110RPS6KC10.49380885
111MAP2K40.48877572
112TAOK20.48766008
113BRD40.48637880
114FGFR10.47835347
115MAPK120.47114452
116RIPK40.47013706
117CDC42BPA0.46664000
118MAP2K20.46597775
119PDPK10.46540049
120MAP3K130.46380887
121TRPM70.45553055
122NLK0.45376087
123HIPK20.44124409
124MAP2K60.43449495
125MAP3K10.43428699
126SRC0.43005839
127ALK0.42580346
128DYRK1B0.42525081
129STK40.41709542
130TYRO30.41528499
131IKBKB0.41383347
132STK380.38779477
133LMTK20.37934858
134RPS6KB20.37834754
135RPS6KA20.36581932
136NUAK10.36143277
137WNK10.36122569

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.30568156
2Viral myocarditis_Homo sapiens_hsa054161.81251204
3AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.76831742
4Other glycan degradation_Homo sapiens_hsa005111.73350049
5ECM-receptor interaction_Homo sapiens_hsa045121.64765812
6B cell receptor signaling pathway_Homo sapiens_hsa046621.64725766
7T cell receptor signaling pathway_Homo sapiens_hsa046601.62413365
8Platelet activation_Homo sapiens_hsa046111.62007689
9Focal adhesion_Homo sapiens_hsa045101.59104151
10Osteoclast differentiation_Homo sapiens_hsa043801.57298161
11Leishmaniasis_Homo sapiens_hsa051401.55745439
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.55626651
13Notch signaling pathway_Homo sapiens_hsa043301.55498122
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.54422906
15Chronic myeloid leukemia_Homo sapiens_hsa052201.53717734
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52381761
17Dilated cardiomyopathy_Homo sapiens_hsa054141.50885452
18Axon guidance_Homo sapiens_hsa043601.49404577
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41056978
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40446419
21Measles_Homo sapiens_hsa051621.40135871
22Lysine degradation_Homo sapiens_hsa003101.39100122
23Proteoglycans in cancer_Homo sapiens_hsa052051.38675924
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38600526
25Toxoplasmosis_Homo sapiens_hsa051451.37211114
26Acute myeloid leukemia_Homo sapiens_hsa052211.34065706
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33409663
28Small cell lung cancer_Homo sapiens_hsa052221.33402476
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29085540
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.27156666
31Choline metabolism in cancer_Homo sapiens_hsa052311.24272135
32Long-term potentiation_Homo sapiens_hsa047201.22622985
33Cholinergic synapse_Homo sapiens_hsa047251.21653430
34Pancreatic cancer_Homo sapiens_hsa052121.18348205
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.18261604
36Circadian entrainment_Homo sapiens_hsa047131.18011852
37HTLV-I infection_Homo sapiens_hsa051661.16574011
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.15256283
39Colorectal cancer_Homo sapiens_hsa052101.12997017
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12120835
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10944004
42Morphine addiction_Homo sapiens_hsa050321.09716022
43Dorso-ventral axis formation_Homo sapiens_hsa043201.09414674
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06522795
45Hematopoietic cell lineage_Homo sapiens_hsa046401.05964439
46Melanogenesis_Homo sapiens_hsa049161.05304189
47Glutamatergic synapse_Homo sapiens_hsa047241.05102833
48Antigen processing and presentation_Homo sapiens_hsa046121.04852030
49Malaria_Homo sapiens_hsa051441.04749293
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03045431
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02358562
52Amoebiasis_Homo sapiens_hsa051461.02300155
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01878606
54Protein digestion and absorption_Homo sapiens_hsa049741.01720211
55Herpes simplex infection_Homo sapiens_hsa051681.01455168
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01431992
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01036455
58Hepatitis B_Homo sapiens_hsa051611.00275424
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99470416
60Ras signaling pathway_Homo sapiens_hsa040140.99196016
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99049356
62Adherens junction_Homo sapiens_hsa045200.97447480
63Chemokine signaling pathway_Homo sapiens_hsa040620.95628920
64ErbB signaling pathway_Homo sapiens_hsa040120.95247901
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94438517
66Insulin resistance_Homo sapiens_hsa049310.94331655
67Cocaine addiction_Homo sapiens_hsa050300.93189594
68Renal cell carcinoma_Homo sapiens_hsa052110.93032980
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92999629
70Shigellosis_Homo sapiens_hsa051310.92995418
71MicroRNAs in cancer_Homo sapiens_hsa052060.92745588
72Apoptosis_Homo sapiens_hsa042100.92244507
73Prion diseases_Homo sapiens_hsa050200.91389547
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91041022
75Gap junction_Homo sapiens_hsa045400.90560152
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.90040505
77Rap1 signaling pathway_Homo sapiens_hsa040150.89130485
78TNF signaling pathway_Homo sapiens_hsa046680.87911509
79Insulin secretion_Homo sapiens_hsa049110.87892776
80Non-small cell lung cancer_Homo sapiens_hsa052230.87604095
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87526187
82VEGF signaling pathway_Homo sapiens_hsa043700.87013396
83Influenza A_Homo sapiens_hsa051640.86646105
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86643283
85Pathways in cancer_Homo sapiens_hsa052000.86478577
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86399501
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84726406
88Basal cell carcinoma_Homo sapiens_hsa052170.84659073
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84604301
90mTOR signaling pathway_Homo sapiens_hsa041500.83611675
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82832856
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.81268862
93Endometrial cancer_Homo sapiens_hsa052130.80435976
94Type II diabetes mellitus_Homo sapiens_hsa049300.79225443
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.78576820
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78353104
97Salmonella infection_Homo sapiens_hsa051320.76613568
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76167707
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73937720
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73719718
101Staphylococcus aureus infection_Homo sapiens_hsa051500.72605450
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72582075
103GABAergic synapse_Homo sapiens_hsa047270.72437446
104Amphetamine addiction_Homo sapiens_hsa050310.72253944
105Dopaminergic synapse_Homo sapiens_hsa047280.71353912
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70869102
107HIF-1 signaling pathway_Homo sapiens_hsa040660.70801876
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70555918
109Oxytocin signaling pathway_Homo sapiens_hsa049210.70163580
110Estrogen signaling pathway_Homo sapiens_hsa049150.68053917
111Insulin signaling pathway_Homo sapiens_hsa049100.67815393
112Calcium signaling pathway_Homo sapiens_hsa040200.67463243
113cAMP signaling pathway_Homo sapiens_hsa040240.66217545
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65244123
115MAPK signaling pathway_Homo sapiens_hsa040100.64584926
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.64410010
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.63716430
118Long-term depression_Homo sapiens_hsa047300.63547916
119Gastric acid secretion_Homo sapiens_hsa049710.63278473
120Prolactin signaling pathway_Homo sapiens_hsa049170.63218941
121FoxO signaling pathway_Homo sapiens_hsa040680.62931603
122Ovarian steroidogenesis_Homo sapiens_hsa049130.62500226
123Glioma_Homo sapiens_hsa052140.61899739
124Viral carcinogenesis_Homo sapiens_hsa052030.60977206
125Tuberculosis_Homo sapiens_hsa051520.60689314
126Nicotine addiction_Homo sapiens_hsa050330.59302940
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.59279514
128Pertussis_Homo sapiens_hsa051330.58824146
129Endocytosis_Homo sapiens_hsa041440.58484580
130Renin secretion_Homo sapiens_hsa049240.57928271
131GnRH signaling pathway_Homo sapiens_hsa049120.56181995
132Inositol phosphate metabolism_Homo sapiens_hsa005620.55392523
133Salivary secretion_Homo sapiens_hsa049700.55199713
134Prostate cancer_Homo sapiens_hsa052150.54398197

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