ADAMTS14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.06292433
2COPI coating of Golgi vesicle (GO:0048205)6.06292433
3negative regulation of erythrocyte differentiation (GO:0045647)5.72835292
4regulation of histone H3-K27 methylation (GO:0061085)5.46444086
5skin morphogenesis (GO:0043589)5.21046442
6hemidesmosome assembly (GO:0031581)5.17278464
7nuclear pore complex assembly (GO:0051292)5.17278001
8endodermal cell differentiation (GO:0035987)5.09505384
9regulation of translational fidelity (GO:0006450)5.08422738
10protein heterotrimerization (GO:0070208)5.01867384
11proline biosynthetic process (GO:0006561)4.94274601
12vitamin A metabolic process (GO:0006776)4.87152268
13regulation of RNA export from nucleus (GO:0046831)4.68698674
14diterpenoid biosynthetic process (GO:0016102)4.63755320
15wound healing, spreading of epidermal cells (GO:0035313)4.54791012
16regulation of early endosome to late endosome transport (GO:2000641)4.54343754
17desmosome organization (GO:0002934)4.47084412
18* collagen fibril organization (GO:0030199)4.43380310
19protoporphyrinogen IX metabolic process (GO:0046501)4.38275518
20regulation of nucleobase-containing compound transport (GO:0032239)4.37354725
21chondrocyte proliferation (GO:0035988)4.24154021
22nuclear pore organization (GO:0006999)4.22408743
23positive regulation of endothelial cell apoptotic process (GO:2000353)4.20910942
24regulation of histone H3-K4 methylation (GO:0051569)4.16097609
25DNA topological change (GO:0006265)4.15529183
26gas transport (GO:0015669)4.12812485
27mannose metabolic process (GO:0006013)4.04850181
28definitive hemopoiesis (GO:0060216)4.03298828
29cell adhesion mediated by integrin (GO:0033627)4.02141655
30embryonic camera-type eye development (GO:0031076)4.01445837
31interferon-gamma production (GO:0032609)4.01187590
32DNA unwinding involved in DNA replication (GO:0006268)3.97414330
33glucose 6-phosphate metabolic process (GO:0051156)3.96186233
34response to vitamin A (GO:0033189)3.93652374
35wound healing, spreading of cells (GO:0044319)3.93062446
36cytolysis (GO:0019835)3.91749161
37vesicle coating (GO:0006901)3.88354836
38erythrocyte maturation (GO:0043249)3.84136574
39retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.82842599
40regulation of mitotic spindle organization (GO:0060236)3.81484632
41basement membrane organization (GO:0071711)3.75733275
42pore complex assembly (GO:0046931)3.72469756
43cell-substrate junction assembly (GO:0007044)3.72246332
44protoporphyrinogen IX biosynthetic process (GO:0006782)3.67593320
45positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.67277449
46oxygen transport (GO:0015671)3.59601738
47* collagen metabolic process (GO:0032963)3.59118708
48negative regulation of potassium ion transmembrane transport (GO:1901380)3.58703868
49iron ion import (GO:0097286)3.57651828
50homocysteine metabolic process (GO:0050667)3.56344739
51* collagen catabolic process (GO:0030574)3.56222278
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54986038
53negative regulation of chondrocyte differentiation (GO:0032331)3.51072719
54atrioventricular valve morphogenesis (GO:0003181)3.47509391
55potassium ion export (GO:0071435)3.44418442
56plasma membrane repair (GO:0001778)3.38655484
57DNA replication checkpoint (GO:0000076)3.35571882
58mitotic chromosome condensation (GO:0007076)3.34777802
59face development (GO:0060324)3.34770177
60apoptotic process involved in morphogenesis (GO:0060561)3.33268110
61protein retention in ER lumen (GO:0006621)3.32786771
62mitotic nuclear envelope disassembly (GO:0007077)3.32714234
63creatine metabolic process (GO:0006600)3.29903245
64* multicellular organismal macromolecule metabolic process (GO:0044259)3.29799307
65terpenoid biosynthetic process (GO:0016114)3.29470678
66paraxial mesoderm development (GO:0048339)3.25586831
67syncytium formation by plasma membrane fusion (GO:0000768)3.25344415
68extracellular matrix disassembly (GO:0022617)3.24970298
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.24353806
70myoblast fusion (GO:0007520)3.24332413
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24215475
72syncytium formation (GO:0006949)3.24125832
73DNA replication initiation (GO:0006270)3.22129617
74regulation of hippo signaling (GO:0035330)3.22019972
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.20415682
76epithelial cell-cell adhesion (GO:0090136)3.20352973
77negative regulation of fatty acid biosynthetic process (GO:0045717)3.18748857
78* multicellular organismal catabolic process (GO:0044243)3.18459320
79regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.17451286
80regulation of response to osmotic stress (GO:0047484)3.14931851
81poly(A)+ mRNA export from nucleus (GO:0016973)3.12943104
82negative regulation of histone methylation (GO:0031061)3.12215791
83nuclear envelope disassembly (GO:0051081)3.11468514
84membrane disassembly (GO:0030397)3.11468514
85histone H4 deacetylation (GO:0070933)3.09233222
86regulation of histone methylation (GO:0031060)3.09035053
87proline metabolic process (GO:0006560)3.08339644
88mitotic sister chromatid segregation (GO:0000070)3.07663395
89midgut development (GO:0007494)3.06825109
90positive regulation of extracellular matrix organization (GO:1903055)3.06656593
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.05617283
92granulocyte differentiation (GO:0030851)3.05526788
93* multicellular organismal metabolic process (GO:0044236)3.05270070
94formation of translation preinitiation complex (GO:0001731)3.05257336
95muscle cell fate commitment (GO:0042693)3.05036998
96response to thyroid hormone (GO:0097066)3.04571584
97regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03406566
98COPII vesicle coating (GO:0048208)3.03172741
99bone trabecula formation (GO:0060346)3.02536773
100positive regulation of nuclease activity (GO:0032075)3.01233745
101negative regulation of biomineral tissue development (GO:0070168)3.01142715
102negative regulation of cartilage development (GO:0061037)3.01006362
103positive regulation of myotube differentiation (GO:0010831)3.00572051
104hematopoietic stem cell differentiation (GO:0060218)2.98714820
105sister chromatid segregation (GO:0000819)2.97729395
106positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.95812238
107positive regulation of astrocyte differentiation (GO:0048711)2.95463957
108heterotypic cell-cell adhesion (GO:0034113)2.94392525
109negative regulation of bone mineralization (GO:0030502)2.94311934
110protein export from nucleus (GO:0006611)2.93231190
111DNA damage induced protein phosphorylation (GO:0006975)2.93028196
112extracellular fibril organization (GO:0043206)2.91142784
113positive regulation of epithelial to mesenchymal transition (GO:0010718)2.90379869
114peptidyl-proline hydroxylation (GO:0019511)2.89348472
115regulation of protein heterodimerization activity (GO:0043497)2.86478420
116cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.86236251
117glomerular basement membrane development (GO:0032836)2.86190634
118fibril organization (GO:0097435)2.83419779
119lens fiber cell development (GO:0070307)2.82291358
120cellular response to thyroid hormone stimulus (GO:0097067)2.82124620
121endoplasmic reticulum unfolded protein response (GO:0030968)2.82085912
122hippo signaling (GO:0035329)2.77017347
123positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.76796372
124labyrinthine layer blood vessel development (GO:0060716)2.76172933
125erythrocyte development (GO:0048821)2.75443700
126negative regulation of fatty acid transport (GO:2000192)2.75101983
127positive regulation of natural killer cell differentiation (GO:0032825)2.74997300
128substrate-dependent cell migration (GO:0006929)2.74281911
129adhesion of symbiont to host (GO:0044406)2.74211588
130positive regulation of blood vessel endothelial cell migration (GO:0043536)2.73237702
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.72320433
132histone H3-K9 demethylation (GO:0033169)2.71187202
133mRNA transcription (GO:0009299)2.71063297
134oxaloacetate metabolic process (GO:0006107)2.68913436
135regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.67802197
136regulation of natural killer cell mediated immunity (GO:0002715)2.67802197
137mesodermal cell differentiation (GO:0048333)2.67786292
138notochord development (GO:0030903)2.67036569
139skeletal muscle fiber development (GO:0048741)2.65999684
140retinoic acid receptor signaling pathway (GO:0048384)2.65815210
141negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65749897
142JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65734153
143regulation of gene silencing by RNA (GO:0060966)2.65107883
144regulation of posttranscriptional gene silencing (GO:0060147)2.65107883
145regulation of gene silencing by miRNA (GO:0060964)2.65107883
146regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.64209613
147ER-nucleus signaling pathway (GO:0006984)2.63700321
148protein-DNA complex disassembly (GO:0032986)2.63583993
149nucleosome disassembly (GO:0006337)2.63583993
150regulation of nuclease activity (GO:0032069)2.63500520
151regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63217787
152phosphorelay signal transduction system (GO:0000160)2.62863125
153cellular response to unfolded protein (GO:0034620)2.62521368
154chondrocyte development (GO:0002063)2.61587841
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.61182911
156axon extension involved in axon guidance (GO:0048846)2.61182911
157substrate adhesion-dependent cell spreading (GO:0034446)2.59559768
158hyaluronan metabolic process (GO:0030212)2.58261483
159negative regulation of smooth muscle cell migration (GO:0014912)2.58077996
160UV protection (GO:0009650)2.56748665
161maintenance of protein localization in organelle (GO:0072595)2.56072218
162endothelial cell chemotaxis (GO:0035767)2.55637594
163adherens junction assembly (GO:0034333)2.55201029
164regulation of SMAD protein import into nucleus (GO:0060390)2.53514496
165anatomical structure regression (GO:0060033)2.53190953
166craniofacial suture morphogenesis (GO:0097094)2.52915844
167negative regulation of cell fate specification (GO:0009996)2.52658359
168apoptotic process involved in development (GO:1902742)2.51138657
169regulation of extracellular matrix disassembly (GO:0010715)2.50263937
170cell migration involved in heart development (GO:0060973)2.50127676
171embryonic cranial skeleton morphogenesis (GO:0048701)2.50078462
172regulation of extracellular matrix organization (GO:1903053)2.49754181
173protein localization to cell surface (GO:0034394)2.49232588
174cell-substrate adherens junction assembly (GO:0007045)2.47837574
175focal adhesion assembly (GO:0048041)2.47837574
176mRNA transcription from RNA polymerase II promoter (GO:0042789)2.47704640
177mesenchymal-epithelial cell signaling (GO:0060638)2.45282975
178cellular defense response (GO:0006968)2.45041140
179sequestering of extracellular ligand from receptor (GO:0035581)2.44943771
180renal filtration (GO:0097205)2.42055840
181regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.41051319
182heart valve morphogenesis (GO:0003179)2.40932272
183epithelial cell fate commitment (GO:0072148)2.39991205
184stress fiber assembly (GO:0043149)2.39933136
185response to laminar fluid shear stress (GO:0034616)2.39705897
186regulation of tight junction assembly (GO:2000810)2.38417466
187cell-matrix adhesion (GO:0007160)2.38144702
188lung-associated mesenchyme development (GO:0060484)2.37839428
189G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.36069398
190negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.35946226
191replacement ossification (GO:0036075)2.35821833
192endochondral ossification (GO:0001958)2.35821833
193polarized epithelial cell differentiation (GO:0030859)2.34872065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.96290694
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.57210801
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.53058768
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40378112
5* GATA1_19941826_ChIP-Seq_K562_Human2.98063033
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58197711
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.58130015
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.51421618
9* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.43687624
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.38762096
11E2F7_22180533_ChIP-Seq_HELA_Human2.29344796
12CLOCK_20551151_ChIP-Seq_293T_Human2.20863613
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15775325
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12367886
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09621767
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.08673265
17* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03398164
18TP63_17297297_ChIP-ChIP_HaCaT_Human10.3666112
19* GATA2_19941826_ChIP-Seq_K562_Human1.98991564
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97353205
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.95967683
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.95967683
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.95967683
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95244948
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93637757
26* SPI1_23127762_ChIP-Seq_K562_Human1.91125244
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88625219
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88625219
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84898346
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78781653
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75290200
32* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73874745
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72989278
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70223216
35* CJUN_26792858_Chip-Seq_BT549_Human1.69051903
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67958064
37BRD4_25478319_ChIP-Seq_HGPS_Human1.67577514
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66413124
39MYC_22102868_ChIP-Seq_BL_Human1.64163285
40* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64158946
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64041512
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62997792
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.61239112
44ATF3_27146783_Chip-Seq_COLON_Human1.59901201
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.56538462
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56237987
47GATA1_22025678_ChIP-Seq_K562_Human1.55558586
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55245030
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54734802
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54616045
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53224910
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52790938
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51676772
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50873670
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50860739
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.49839959
57ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49076043
58RACK7_27058665_Chip-Seq_MCF-7_Human1.48841423
59* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47982362
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46934646
61* UBF1/2_26484160_Chip-Seq_HMECs_Human1.46754215
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46748022
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45768282
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.44660581
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44614264
66SCL_19346495_ChIP-Seq_HPC-7_Human1.44057932
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.44051744
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43884664
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.43015038
70KDM2B_26808549_Chip-Seq_DND41_Human1.42993794
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.41144754
72TP53_22127205_ChIP-Seq_IMR90_Human1.40107832
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39716556
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38214821
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37695333
76* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36528311
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35995494
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.34544920
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33543784
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.33098175
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31843315
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30026397
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29445010
84XRN2_22483619_ChIP-Seq_HELA_Human1.29192417
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28517814
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25941142
87ZNF263_19887448_ChIP-Seq_K562_Human1.25886910
88* LXR_22292898_ChIP-Seq_THP-1_Human1.25865691
89VDR_21846776_ChIP-Seq_THP-1_Human1.25787756
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25419353
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25156011
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24616040
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24295955
94CREB1_26743006_Chip-Seq_LNCaP_Human1.23709453
95* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23041870
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22530157
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21082516
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19928046
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.18524966
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17700554
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17367696
102SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16982414
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16631570
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.16551362
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.15049173
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14999003
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14775705
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14165744
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.13203697
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12691764
111KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12640654
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12570067
113P68_20966046_ChIP-Seq_HELA_Human1.10152148
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10110917
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09225270
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08795736
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08465789
118* NCOR1_26117541_ChIP-Seq_K562_Human1.07715615
119JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06710699
120RUNX1_27514584_Chip-Seq_MCF-7_Human1.06522535
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05780195
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04878867
123ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04384373
124GATA1_19941827_ChIP-Seq_MEL_Mouse1.03050953
125MAF_26560356_Chip-Seq_TH2_Human1.01294850
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00859825
127KDM2B_26808549_Chip-Seq_K562_Human1.00841908
128MAF_26560356_Chip-Seq_TH1_Human1.00803518
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00041858
130MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99596900
131TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96873433
132UTX_26944678_Chip-Seq_JUKART_Human0.96770292
133* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96503809
134* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96469689
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95542584
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94889630
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94237956
138NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94007192
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93956353
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.93490514
141TBX20_22080862_ChIP-Seq_HEART_Mouse0.93490514
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93194347
143MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93154730
144VDR_24763502_ChIP-Seq_THP-1_Human0.93008065
145TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92379971
146* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92303798
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92095483
148* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91956605
149RUNX_20019798_ChIP-Seq_JUKART_Human0.91530035
150SMC4_20622854_ChIP-Seq_HELA_Human0.90960971
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89740782
152RUNX1_22412390_ChIP-Seq_EML_Mouse0.89458183
153KLF5_25053715_ChIP-Seq_YYC3_Human0.86550920
154NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85251440
155* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83394963
156DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82610735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.27049926
2MP0005275_abnormal_skin_tensile4.34123028
3MP0003705_abnormal_hypodermis_morpholog3.68044255
4MP0000678_abnormal_parathyroid_gland3.58840110
5MP0005451_abnormal_body_composition2.97705294
6MP0005503_abnormal_tendon_morphology2.93530561
7MP0010030_abnormal_orbit_morphology2.70406561
8MP0004272_abnormal_basement_membrane2.61655299
9MP0004147_increased_porphyrin_level2.60327438
10MP0000733_abnormal_muscle_development2.58057735
11MP0005623_abnormal_meninges_morphology2.54766048
12MP0003656_abnormal_erythrocyte_physiolo2.53081089
13MP0003279_aneurysm2.50527450
14MP0002060_abnormal_skin_morphology2.48570377
15MP0003566_abnormal_cell_adhesion2.46532686
16MP0010352_gastrointestinal_tract_polyps2.32692708
17MP0001545_abnormal_hematopoietic_system2.30876882
18MP0005397_hematopoietic_system_phenotyp2.30876882
19MP0003941_abnormal_skin_development2.22520754
20MP0008995_early_reproductive_senescence2.07118126
21MP0005083_abnormal_biliary_tract2.02821516
22MP0000750_abnormal_muscle_regeneration1.97009328
23MP0003950_abnormal_plasma_membrane1.93679352
24MP0005058_abnormal_lysosome_morphology1.93458575
25MP0003448_altered_tumor_morphology1.90623552
26MP0000383_abnormal_hair_follicle1.89735293
27MP0001958_emphysema1.86092648
28MP0003283_abnormal_digestive_organ1.83689844
29MP0009840_abnormal_foam_cell1.82160153
30MP0002796_impaired_skin_barrier1.81384887
31MP0005023_abnormal_wound_healing1.81104350
32MP0003091_abnormal_cell_migration1.74187847
33MP0003453_abnormal_keratinocyte_physiol1.72658113
34MP0005076_abnormal_cell_differentiation1.71908507
35MP0004233_abnormal_muscle_weight1.71162769
36MP0005508_abnormal_skeleton_morphology1.65290573
37MP0001243_abnormal_dermal_layer1.63044121
38MP0000858_altered_metastatic_potential1.60909266
39MP0003111_abnormal_nucleus_morphology1.60593430
40MP0004145_abnormal_muscle_electrophysio1.60214819
41MP0002877_abnormal_melanocyte_morpholog1.56934606
42MP0004957_abnormal_blastocyst_morpholog1.56869960
43MP0000762_abnormal_tongue_morphology1.53671680
44MP0000751_myopathy1.53497909
45MP0001542_abnormal_bone_strength1.51199796
46MP0009278_abnormal_bone_marrow1.46777632
47MP0002249_abnormal_larynx_morphology1.46055408
48MP0009384_cardiac_valve_regurgitation1.45750542
49MP0010307_abnormal_tumor_latency1.45629651
50MP0006082_CNS_inflammation1.42772503
51MP0005501_abnormal_skin_physiology1.40975132
52MP0010234_abnormal_vibrissa_follicle1.39811823
53MP0002108_abnormal_muscle_morphology1.38449785
54MP0002282_abnormal_trachea_morphology1.37647252
55MP0009250_abnormal_appendicular_skeleto1.36125657
56MP0010678_abnormal_skin_adnexa1.31672612
57MP0005257_abnormal_intraocular_pressure1.31597114
58MP0004134_abnormal_chest_morphology1.28870838
59MP0002396_abnormal_hematopoietic_system1.28636502
60MP0006054_spinal_hemorrhage1.26369045
61MP0001299_abnormal_eye_distance/1.25944878
62MP0008004_abnormal_stomach_pH1.22833296
63MP0008932_abnormal_embryonic_tissue1.21847720
64MP0005409_darkened_coat_color1.21362144
65MP0002896_abnormal_bone_mineralization1.21135656
66MP0009053_abnormal_anal_canal1.18569582
67MP0001216_abnormal_epidermal_layer1.17754077
68MP0010771_integument_phenotype1.17431214
69MP0003385_abnormal_body_wall1.16603528
70MP0000467_abnormal_esophagus_morphology1.16310926
71MP0003755_abnormal_palate_morphology1.15582520
72MP0000681_abnormal_thyroid_gland1.11700533
73MP0008007_abnormal_cellular_replicative1.11310629
74MP0001661_extended_life_span1.09564884
75MP0002089_abnormal_postnatal_growth/wei1.08856031
76MP0002132_abnormal_respiratory_system1.07218064
77MP0005671_abnormal_response_to1.06649953
78MP0002932_abnormal_joint_morphology1.05732526
79MP0001730_embryonic_growth_arrest1.04824334
80MP0000163_abnormal_cartilage_morphology1.03334478
81MP0004858_abnormal_nervous_system1.03334332
82MP0002269_muscular_atrophy1.03194118
83MP0002006_tumorigenesis1.02693573
84MP0000432_abnormal_head_morphology1.02440838
85MP0000767_abnormal_smooth_muscle1.01018327
86MP0000759_abnormal_skeletal_muscle1.00936747
87MP0004084_abnormal_cardiac_muscle1.00527612
88MP0003786_premature_aging1.00305020
89MP0003045_fibrosis0.98331260
90MP0001348_abnormal_lacrimal_gland0.97728153
91MP0004197_abnormal_fetal_growth/weight/0.96678037
92MP0003115_abnormal_respiratory_system0.96616398
93MP0005390_skeleton_phenotype0.96497780
94MP0003300_gastrointestinal_ulcer0.96420982
95MP0002111_abnormal_tail_morphology0.95092891
96MP0003959_abnormal_lean_body0.94880955
97MP0000428_abnormal_craniofacial_morphol0.94726778
98MP0002933_joint_inflammation0.94640922
99MP0002115_abnormal_skeleton_extremities0.93738265
100MP0002080_prenatal_lethality0.92617450
101MP0002234_abnormal_pharynx_morphology0.89972629
102MP0000749_muscle_degeneration0.89269532
103MP0000377_abnormal_hair_follicle0.88891769
104MP0004947_skin_inflammation0.88600674
105MP0002113_abnormal_skeleton_development0.87289810
106MP0004087_abnormal_muscle_fiber0.87253942
107MP0000350_abnormal_cell_proliferation0.86911865
108MP0003942_abnormal_urinary_system0.85575905
109MP0001849_ear_inflammation0.85225416
110MP0003935_abnormal_craniofacial_develop0.84964224
111MP0002925_abnormal_cardiovascular_devel0.83244509
112MP0003436_decreased_susceptibility_to0.83214570
113MP0004185_abnormal_adipocyte_glucose0.81780520
114MP0002998_abnormal_bone_remodeling0.80772548
115MP0001873_stomach_inflammation0.80766329
116MP0000579_abnormal_nail_morphology0.78392335
117MP0001915_intracranial_hemorrhage0.77408143
118MP0000313_abnormal_cell_death0.77060448
119MP0005621_abnormal_cell_physiology0.76865877
120MP0010630_abnormal_cardiac_muscle0.76190585
121MP0004808_abnormal_hematopoietic_stem0.75587835
122MP0001697_abnormal_embryo_size0.74948779
123MP0008058_abnormal_DNA_repair0.74881090
124MP0002086_abnormal_extraembryonic_tissu0.74668665
125MP0000537_abnormal_urethra_morphology0.74604617
126MP0002009_preneoplasia0.74558797
127MP0002109_abnormal_limb_morphology0.74386935
128MP0000627_abnormal_mammary_gland0.73870948
129MP0002166_altered_tumor_susceptibility0.73182814
130MP0009931_abnormal_skin_appearance0.72572350
131MP0000343_altered_response_to0.72559753
132MP0000266_abnormal_heart_morphology0.72306452
133MP0001614_abnormal_blood_vessel0.72010230
134MP0002114_abnormal_axial_skeleton0.70709794
135MP0003172_abnormal_lysosome_physiology0.69628214
136MP0002116_abnormal_craniofacial_bone0.69586719
137MP0005369_muscle_phenotype0.69519652
138MP0002697_abnormal_eye_size0.69212862
139MP0005380_embryogenesis_phenotype0.69015352
140MP0001672_abnormal_embryogenesis/_devel0.69015352
141MP0000747_muscle_weakness0.68699155
142MP0000647_abnormal_sebaceous_gland0.68433334
143MP0003984_embryonic_growth_retardation0.67719726
144MP0002106_abnormal_muscle_physiology0.67190913
145MP0002128_abnormal_blood_circulation0.66960752
146MP0003693_abnormal_embryo_hatching0.66230372
147MP0003795_abnormal_bone_structure0.65125624
148MP0004036_abnormal_muscle_relaxation0.64421297
149MP0005171_absent_coat_pigmentation0.64168363
150MP0010094_abnormal_chromosome_stability0.63895296
151MP0003077_abnormal_cell_cycle0.63749864

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)6.31699681
2Abnormal gallbladder physiology (HP:0012438)6.31699681
3Protrusio acetabuli (HP:0003179)5.45394581
4Premature rupture of membranes (HP:0001788)5.33894748
5Reticulocytosis (HP:0001923)4.81268565
6Truncus arteriosus (HP:0001660)4.74547984
7Atrophic scars (HP:0001075)4.53032552
8Polycythemia (HP:0001901)4.25500026
9Type 1 muscle fiber predominance (HP:0003803)4.20124940
10Ankle contracture (HP:0006466)4.04209840
11Atelectasis (HP:0100750)3.87485997
12Hyperthyroidism (HP:0000836)3.83848282
13Flat cornea (HP:0007720)3.83819314
14Nonimmune hydrops fetalis (HP:0001790)3.68925967
15Disproportionate tall stature (HP:0001519)3.64582918
16Increased connective tissue (HP:0009025)3.64521448
17Fragile skin (HP:0001030)3.54834459
18Abnormality of reticulocytes (HP:0004312)3.44937189
19Hypertensive crisis (HP:0100735)3.42497489
20Alopecia of scalp (HP:0002293)3.41668657
21Aortic dissection (HP:0002647)3.38700151
22Shallow orbits (HP:0000586)3.38649695
23Follicular hyperkeratosis (HP:0007502)3.37649831
24Bowel incontinence (HP:0002607)3.30158014
25Neonatal short-limb short stature (HP:0008921)3.28652068
26Milia (HP:0001056)3.24893569
27Cerebral aneurysm (HP:0004944)3.20932647
28Abnormality of the tricuspid valve (HP:0001702)3.16954155
29Abnormal large intestine physiology (HP:0012700)3.15762124
30Spinal rigidity (HP:0003306)3.10394306
31Ileus (HP:0002595)3.09094766
32Insomnia (HP:0100785)2.96256702
33Malignant hyperthermia (HP:0002047)2.92392323
34Slender build (HP:0001533)2.89866096
35Mildly elevated creatine phosphokinase (HP:0008180)2.89411478
36Venous insufficiency (HP:0005293)2.83476840
37Cholelithiasis (HP:0001081)2.81248075
38Genu recurvatum (HP:0002816)2.75654406
39Round ear (HP:0100830)2.74604333
40Peritonitis (HP:0002586)2.72981597
41Dilatation of the ascending aorta (HP:0005111)2.71458811
42Seborrheic dermatitis (HP:0001051)2.67884414
43Soft skin (HP:0000977)2.66985989
44Increased variability in muscle fiber diameter (HP:0003557)2.66046731
45Abnormality of skeletal muscle fiber size (HP:0012084)2.65735980
46Popliteal pterygium (HP:0009756)2.64079747
47Thin bony cortex (HP:0002753)2.63190583
48Venous abnormality (HP:0002624)2.62903926
49Difficulty climbing stairs (HP:0003551)2.62268638
50Aortic aneurysm (HP:0004942)2.59855420
51Hand muscle atrophy (HP:0009130)2.59131945
52Thin ribs (HP:0000883)2.58405010
53Hyperacusis (HP:0010780)2.50421739
54Mitral valve prolapse (HP:0001634)2.50326857
55Distal lower limb amyotrophy (HP:0008944)2.48184007
56Pterygium (HP:0001059)2.46960832
57Bladder diverticulum (HP:0000015)2.46820511
58Abnormal hemoglobin (HP:0011902)2.42940991
59Patellar dislocation (HP:0002999)2.42886637
60Wormian bones (HP:0002645)2.40243882
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37584096
62Premature skin wrinkling (HP:0100678)2.36943244
63Abnormal gallbladder morphology (HP:0012437)2.35377864
64Blue sclerae (HP:0000592)2.35275851
65Broad metatarsal (HP:0001783)2.34760005
66Aplasia of the musculature (HP:0100854)2.33881145
67Abnormality of the neuromuscular junction (HP:0003398)2.33701733
68Fatigable weakness (HP:0003473)2.33701733
69Ectopia lentis (HP:0001083)2.32788481
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.30515545
71Osteolytic defects of the hand bones (HP:0009699)2.30515545
72Trismus (HP:0000211)2.23583173
73Short 4th metacarpal (HP:0010044)2.22589903
74Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22589903
75Upper limb muscle weakness (HP:0003484)2.21296570
76Ulnar bowing (HP:0003031)2.21043724
77Myopathic facies (HP:0002058)2.20955285
78Hypoparathyroidism (HP:0000829)2.18916415
79Hammertoe (HP:0001765)2.18162584
80Coronal craniosynostosis (HP:0004440)2.17580589
81Increased density of long bones (HP:0006392)2.16822302
82Muscle fiber inclusion bodies (HP:0100299)2.15863005
83Hip contracture (HP:0003273)2.15303421
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.14570796
85Abnormality of the calcaneus (HP:0008364)2.13476284
86Biconcave vertebral bodies (HP:0004586)2.11671323
87Wrist flexion contracture (HP:0001239)2.11547407
88Cervical subluxation (HP:0003308)2.10559829
89Abnormality of dentin (HP:0010299)2.10201431
90Bilateral sensorineural hearing impairment (HP:0008619)2.10176182
91Muscle fiber splitting (HP:0003555)2.09935469
92Breech presentation (HP:0001623)2.07424463
93Renal duplication (HP:0000075)2.06109339
94Hemiplegia (HP:0002301)2.05825832
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03834296
96Selective tooth agenesis (HP:0001592)2.00616180
97Gastrointestinal dysmotility (HP:0002579)2.00218971
98Scapular winging (HP:0003691)1.99818691
99Abnormality of cochlea (HP:0000375)1.99121282
100Male infertility (HP:0003251)1.98865405
101Joint laxity (HP:0001388)1.98498377
102Hypoplastic ischia (HP:0003175)1.97957557
103Abnormality of the gallbladder (HP:0005264)1.97667066
104Ulnar deviation of the wrist (HP:0003049)1.97382767
105Slender long bone (HP:0003100)1.97248644
106Abnormality of the acetabulum (HP:0003170)1.96423463
107Increased nuchal translucency (HP:0010880)1.96220930
108Metaphyseal cupping (HP:0003021)1.94371469
109Fetal akinesia sequence (HP:0001989)1.94284157
110Distal arthrogryposis (HP:0005684)1.93367819
111Distal lower limb muscle weakness (HP:0009053)1.93185942
112Limited hip movement (HP:0008800)1.93038076
113Orthostatic hypotension (HP:0001278)1.92823746
114Homocystinuria (HP:0002156)1.92289855
115Abnormality of homocysteine metabolism (HP:0010919)1.92289855
116Elbow flexion contracture (HP:0002987)1.90990410
117Nemaline bodies (HP:0003798)1.90829705
118Birth length less than 3rd percentile (HP:0003561)1.90770134
119Abnormality of the heme biosynthetic pathway (HP:0010472)1.89965940
120Acute myeloid leukemia (HP:0004808)1.89167794
121Long eyelashes (HP:0000527)1.88141010
122Easy fatigability (HP:0003388)1.87235289
123Pointed chin (HP:0000307)1.86266257
124Calcaneovalgus deformity (HP:0001848)1.85694516
125Cortical dysplasia (HP:0002539)1.85451210
126Diaphragmatic weakness (HP:0009113)1.83036427
127Obstructive sleep apnea (HP:0002870)1.82994244
128Hyperextensible skin (HP:0000974)1.82959147
129Amniotic constriction ring (HP:0009775)1.81402547
130Abnormality of placental membranes (HP:0011409)1.81402547
131Abnormal vertebral ossification (HP:0100569)1.81139178
132Vertebral compression fractures (HP:0002953)1.81022545
133Down-sloping shoulders (HP:0200021)1.80127127
134Epiphyseal dysplasia (HP:0002656)1.79990991
135Infantile muscular hypotonia (HP:0008947)1.79933792
136Abnormal delivery (HP:0001787)1.79885390
137Abnormality of oral frenula (HP:0000190)1.79746340
138Vascular tortuosity (HP:0004948)1.78701318
139Ankyloglossia (HP:0010296)1.78160996
140Cheekbone underdevelopment (HP:0010669)1.77504446
141Hyporeflexia of lower limbs (HP:0002600)1.77240441
142Mitral regurgitation (HP:0001653)1.76764736
143Right ventricular cardiomyopathy (HP:0011663)1.75773036
144Spondylolisthesis (HP:0003302)1.75544728
145Knee flexion contracture (HP:0006380)1.75534609
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75429396
147Renovascular hypertension (HP:0100817)1.74833494
148Abnormal albumin level (HP:0012116)1.72526120
149Hypoalbuminemia (HP:0003073)1.72526120
150Mesomelia (HP:0003027)1.72501282
151Deviation of the hallux (HP:0010051)1.70581008
152Upper limb amyotrophy (HP:0009129)1.69503999
153Distal upper limb amyotrophy (HP:0007149)1.69503999
154Tibial bowing (HP:0002982)1.69245325
155Lower limb amyotrophy (HP:0007210)1.69153951
156Vertebral clefting (HP:0008428)1.67899571
157Generalized amyotrophy (HP:0003700)1.65894709
158Hallux valgus (HP:0001822)1.65201373
159Osteoarthritis (HP:0002758)1.64937823
160Bowel diverticulosis (HP:0005222)1.64724461
161Deformed tarsal bones (HP:0008119)1.64512193
162Abnormality of the ischium (HP:0003174)1.64507622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.80617966
2DDR23.35971771
3TRIB33.33851304
4KSR23.28861636
5TTN3.13450698
6CLK13.03838836
7EPHA22.94712459
8SIK12.84959377
9MOS2.77348824
10PKN22.75088147
11MAP3K102.41686883
12TTK2.31323555
13LATS12.29871853
14EEF2K2.29143415
15BMX2.23670707
16EIF2AK12.14220328
17NME12.08886043
18PDGFRA2.08017168
19MAP3K21.98403599
20STK101.94123872
21NTRK31.88671288
22ERN11.87693996
23IRAK31.85077932
24RIPK11.81523431
25NTRK11.76839264
26PRPF4B1.75820795
27TRPM71.75072731
28BMPR21.73304524
29CDK121.67683109
30PAK21.67104018
31DYRK1B1.66970109
32LATS21.65353541
33RAF11.61873808
34PAK41.59315492
35JAK11.59238948
36LRRK21.56536500
37TXK1.55029189
38FER1.52459704
39FGFR11.48768924
40KSR11.45633522
41RPS6KB21.44073794
42EPHB11.43112337
43NME21.41250655
44MAPKAPK31.37532382
45RPS6KA41.31648772
46MST41.30603297
47MAP3K61.29642037
48CCNB11.26314076
49CDK61.22153410
50EPHA31.19397424
51PIM21.19286871
52CDC42BPA1.19241500
53FGFR41.12610842
54PTK21.11226632
55PTK61.09190917
56MET1.07999927
57EPHB21.07186230
58MTOR1.06878110
59GRK71.04585419
60PIK3CG1.03911217
61WNK11.01021457
62STK30.95790222
63FGFR30.95434362
64RET0.95348634
65PDGFRB0.93440425
66MATK0.93131091
67MAP3K10.90951429
68WNK40.90897244
69CHUK0.90432095
70ROCK20.88816788
71TESK10.87841689
72ROCK10.86709647
73PLK40.86562009
74JAK30.86454187
75PIM10.85886125
76TGFBR20.85872920
77DMPK0.85688183
78TYK20.85185497
79CDK40.84882264
80NEK20.84359215
81MARK20.83688434
82ICK0.82850335
83ADRBK20.82325250
84MAP3K30.77436959
85PAK60.75592896
86ILK0.72624694
87SIK20.69689501
88TYRO30.69558824
89JAK20.68761239
90CAMK1D0.66499531
91STK40.66455576
92LIMK10.66425930
93CSK0.66328033
94SMG10.66180756
95CDK70.66042006
96MAP3K80.65282331
97INSR0.65253126
98ALK0.60900561
99MST1R0.60582304
100MAP3K130.60236090
101MYLK0.60051443
102BRAF0.60017045
103PRKG20.59129375
104MAP2K10.58535227
105ITK0.58367590
106CHEK10.57897758
107CHEK20.54882364
108TAOK20.53994373
109FLT30.52323156
110WEE10.51011019
111CDK10.50851154
112BRSK10.49968035
113STK38L0.48985737
114GSK3A0.48648475
115PTK2B0.48140515
116CDK20.48091756
117MAPK100.47903369
118MAP2K60.47455393
119BUB10.46036544
120TNK20.45624034
121BRSK20.44318738
122MAP3K70.43583853
123MAPKAPK50.43573409
124RPS6KA20.42820886
125CDC70.41454323
126MARK30.40754722
127SIK30.40368529
128TESK20.40055234
129ERBB20.40054315
130ERBB30.39505494
131PAK30.39135983
132MAP2K30.38988574
133MAPK90.38649763
134PAK10.38437252
135AKT20.37414638
136PRKD20.36497739
137MAPK150.36237372
138PBK0.36184513
139MAPK10.35800894
140CDK150.35133306
141BLK0.34913101
142AURKB0.34748996
143RPS6KL10.34576683
144RPS6KC10.34576683
145MAPK30.33721880
146SCYL20.33055126
147MAPKAPK20.33035505
148RPS6KA60.31839167
149CDK11A0.30256080
150SRC0.29695792
151CDK180.29399923
152STK240.28769539

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005246.22093713
2Graft-versus-host disease_Homo sapiens_hsa053323.72204669
3ECM-receptor interaction_Homo sapiens_hsa045123.56867707
4Other glycan degradation_Homo sapiens_hsa005113.09694223
5Viral myocarditis_Homo sapiens_hsa054162.70502289
6Focal adhesion_Homo sapiens_hsa045102.56947540
7Fructose and mannose metabolism_Homo sapiens_hsa000512.37800371
8Allograft rejection_Homo sapiens_hsa053302.36379538
9Small cell lung cancer_Homo sapiens_hsa052222.19288892
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12121028
11Proteoglycans in cancer_Homo sapiens_hsa052052.09081600
12Basal cell carcinoma_Homo sapiens_hsa052171.99673129
13Bladder cancer_Homo sapiens_hsa052191.90193328
14MicroRNAs in cancer_Homo sapiens_hsa052061.88764751
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86751847
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.81796227
17Amoebiasis_Homo sapiens_hsa051461.81399517
18p53 signaling pathway_Homo sapiens_hsa041151.81378196
19Adherens junction_Homo sapiens_hsa045201.80021986
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79239206
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78120922
22Notch signaling pathway_Homo sapiens_hsa043301.77476239
23Hedgehog signaling pathway_Homo sapiens_hsa043401.76736363
24Protein digestion and absorption_Homo sapiens_hsa049741.74154289
25Autoimmune thyroid disease_Homo sapiens_hsa053201.66732429
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.65662124
27Hippo signaling pathway_Homo sapiens_hsa043901.61725746
28Malaria_Homo sapiens_hsa051441.60705758
29Biosynthesis of amino acids_Homo sapiens_hsa012301.57331965
30Prion diseases_Homo sapiens_hsa050201.54363667
31Chronic myeloid leukemia_Homo sapiens_hsa052201.51491830
32Pentose phosphate pathway_Homo sapiens_hsa000301.51057099
33Dilated cardiomyopathy_Homo sapiens_hsa054141.47205138
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.46962139
35HTLV-I infection_Homo sapiens_hsa051661.42943460
36DNA replication_Homo sapiens_hsa030301.39257555
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37811950
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.36155613
39PI3K-Akt signaling pathway_Homo sapiens_hsa041511.36018520
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34911215
41Type I diabetes mellitus_Homo sapiens_hsa049401.32956642
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32503572
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.31634874
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31340843
45Apoptosis_Homo sapiens_hsa042101.29481227
46TGF-beta signaling pathway_Homo sapiens_hsa043501.26826622
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25210393
48Toxoplasmosis_Homo sapiens_hsa051451.23852815
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22272740
50Carbon metabolism_Homo sapiens_hsa012001.18052848
51Type II diabetes mellitus_Homo sapiens_hsa049301.15453378
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14616043
53Antigen processing and presentation_Homo sapiens_hsa046121.04714291
54Melanoma_Homo sapiens_hsa052181.04591933
55Galactose metabolism_Homo sapiens_hsa000521.03298229
56Insulin signaling pathway_Homo sapiens_hsa049101.03097604
57Pathways in cancer_Homo sapiens_hsa052001.02269461
58Prostate cancer_Homo sapiens_hsa052151.00350483
59Pancreatic cancer_Homo sapiens_hsa052120.98965629
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.98941229
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.97077417
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96797866
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95894202
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95682998
65Shigellosis_Homo sapiens_hsa051310.95067079
66Viral carcinogenesis_Homo sapiens_hsa052030.94796614
67One carbon pool by folate_Homo sapiens_hsa006700.93923964
68Colorectal cancer_Homo sapiens_hsa052100.93881996
69Mismatch repair_Homo sapiens_hsa034300.93878108
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93238110
71mRNA surveillance pathway_Homo sapiens_hsa030150.93078220
72Wnt signaling pathway_Homo sapiens_hsa043100.92971732
73Acute myeloid leukemia_Homo sapiens_hsa052210.90387210
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89883705
75Platelet activation_Homo sapiens_hsa046110.89582384
76Dorso-ventral axis formation_Homo sapiens_hsa043200.88739673
77Tight junction_Homo sapiens_hsa045300.86408919
78Homologous recombination_Homo sapiens_hsa034400.85007618
79GnRH signaling pathway_Homo sapiens_hsa049120.83617605
80Cell cycle_Homo sapiens_hsa041100.83261255
81Pyruvate metabolism_Homo sapiens_hsa006200.82394296
82Hepatitis B_Homo sapiens_hsa051610.81871497
83Axon guidance_Homo sapiens_hsa043600.81701815
84Rap1 signaling pathway_Homo sapiens_hsa040150.80523044
85Arginine biosynthesis_Homo sapiens_hsa002200.78097866
86TNF signaling pathway_Homo sapiens_hsa046680.77099047
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.76351863
88Leishmaniasis_Homo sapiens_hsa051400.75440796
89Choline metabolism in cancer_Homo sapiens_hsa052310.75412141
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.74857854
91Glioma_Homo sapiens_hsa052140.73590045
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72654608
93Steroid biosynthesis_Homo sapiens_hsa001000.72415373
94Measles_Homo sapiens_hsa051620.71928713
95Endometrial cancer_Homo sapiens_hsa052130.70986297
96Osteoclast differentiation_Homo sapiens_hsa043800.69648135
97VEGF signaling pathway_Homo sapiens_hsa043700.69624211
98Renal cell carcinoma_Homo sapiens_hsa052110.69000612
99mTOR signaling pathway_Homo sapiens_hsa041500.68874852
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64820286
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64742074
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63472092
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63233785
104Nucleotide excision repair_Homo sapiens_hsa034200.61306362
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61232436
106FoxO signaling pathway_Homo sapiens_hsa040680.60912045
107HIF-1 signaling pathway_Homo sapiens_hsa040660.60315465
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60140946
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59264295
110Spliceosome_Homo sapiens_hsa030400.57829835
111Non-small cell lung cancer_Homo sapiens_hsa052230.55106703
112T cell receptor signaling pathway_Homo sapiens_hsa046600.54797578
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.51214190
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50613566
115Endocytosis_Homo sapiens_hsa041440.50152529
116Thyroid cancer_Homo sapiens_hsa052160.48230912
117Epstein-Barr virus infection_Homo sapiens_hsa051690.47350798
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.46872905
119Inositol phosphate metabolism_Homo sapiens_hsa005620.46770873
120RNA transport_Homo sapiens_hsa030130.45912484
121ErbB signaling pathway_Homo sapiens_hsa040120.45764385
122Salmonella infection_Homo sapiens_hsa051320.44157021
123MAPK signaling pathway_Homo sapiens_hsa040100.44130749
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.43917240
125Ras signaling pathway_Homo sapiens_hsa040140.42249681
126Long-term potentiation_Homo sapiens_hsa047200.42150928
127Base excision repair_Homo sapiens_hsa034100.41550978
128N-Glycan biosynthesis_Homo sapiens_hsa005100.41409252
129Prolactin signaling pathway_Homo sapiens_hsa049170.41042983
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40729266
131Hepatitis C_Homo sapiens_hsa051600.40621552
132Insulin resistance_Homo sapiens_hsa049310.39379870
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38953917
134Mineral absorption_Homo sapiens_hsa049780.38761518
135Pertussis_Homo sapiens_hsa051330.38047041
136Melanogenesis_Homo sapiens_hsa049160.38013561
137Hematopoietic cell lineage_Homo sapiens_hsa046400.37650579
138AMPK signaling pathway_Homo sapiens_hsa041520.37596359
139Influenza A_Homo sapiens_hsa051640.37480490
140Ribosome_Homo sapiens_hsa030100.36968082
141Lysine degradation_Homo sapiens_hsa003100.36669075
142Lysosome_Homo sapiens_hsa041420.35947080
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35802809
144Estrogen signaling pathway_Homo sapiens_hsa049150.35059529
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34903353
146Gap junction_Homo sapiens_hsa045400.34513529
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33001225
148B cell receptor signaling pathway_Homo sapiens_hsa046620.32509606

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