ADAMTS15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.89165294
2extracellular fibril organization (GO:0043206)4.50522528
3collagen fibril organization (GO:0030199)4.37927242
4collagen metabolic process (GO:0032963)4.08540112
5collagen catabolic process (GO:0030574)4.02164141
6cell proliferation involved in metanephros development (GO:0072203)4.01882015
7multicellular organismal macromolecule metabolic process (GO:0044259)4.00784299
8multicellular organismal catabolic process (GO:0044243)3.88155796
9multicellular organismal metabolic process (GO:0044236)3.83595959
10bone trabecula formation (GO:0060346)3.77976963
11endocardial cushion morphogenesis (GO:0003203)3.68971108
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.68036248
13glomerular filtration (GO:0003094)3.67235464
14renal filtration (GO:0097205)3.64223056
15fibril organization (GO:0097435)3.63990340
16retina vasculature morphogenesis in camera-type eye (GO:0061299)3.62664916
17basement membrane organization (GO:0071711)3.58436110
18sequestering of extracellular ligand from receptor (GO:0035581)3.53997925
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.51429257
20axon extension involved in axon guidance (GO:0048846)3.51429257
21dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.49272918
22atrioventricular valve morphogenesis (GO:0003181)3.48481708
23regulation of cardioblast differentiation (GO:0051890)3.45460551
24polarized epithelial cell differentiation (GO:0030859)3.43241814
25cardiac myofibril assembly (GO:0055003)3.42972486
26cell migration involved in heart development (GO:0060973)3.40369462
27low-density lipoprotein particle clearance (GO:0034383)3.39922881
28extracellular matrix disassembly (GO:0022617)3.37641480
29mesenchyme morphogenesis (GO:0072132)3.36932915
30metanephric mesenchyme development (GO:0072075)3.36121411
31adherens junction assembly (GO:0034333)3.34878798
32desmosome organization (GO:0002934)3.32038514
33cell proliferation involved in kidney development (GO:0072111)3.25693242
34cell adhesion mediated by integrin (GO:0033627)3.23380364
35vascular endothelial growth factor signaling pathway (GO:0038084)3.22057128
36regulation of transforming growth factor beta2 production (GO:0032909)3.17982369
37endodermal cell differentiation (GO:0035987)3.11809146
38blood vessel maturation (GO:0001955)3.11006185
39paraxial mesoderm development (GO:0048339)3.10931378
40negative regulation of catenin import into nucleus (GO:0035414)3.04237845
41cell-substrate adherens junction assembly (GO:0007045)3.01860659
42focal adhesion assembly (GO:0048041)3.01860659
43COPI coating of Golgi vesicle (GO:0048205)2.98647958
44Golgi transport vesicle coating (GO:0048200)2.98647958
45type B pancreatic cell proliferation (GO:0044342)2.98481590
46regulation of endothelial cell differentiation (GO:0045601)2.96976039
47kidney mesenchyme development (GO:0072074)2.96472624
48semaphorin-plexin signaling pathway (GO:0071526)2.95587463
49barbed-end actin filament capping (GO:0051016)2.95359848
50glomerular basement membrane development (GO:0032836)2.93818293
51planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85936703
52negative regulation of smooth muscle cell migration (GO:0014912)2.84483117
53insulin-like growth factor receptor signaling pathway (GO:0048009)2.83743277
54extracellular matrix assembly (GO:0085029)2.82341951
55positive regulation of endothelial cell apoptotic process (GO:2000353)2.82085213
56peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.79164613
57branching involved in salivary gland morphogenesis (GO:0060445)2.78325237
58surfactant homeostasis (GO:0043129)2.77531907
59protein localization to cell surface (GO:0034394)2.77462937
60epithelial cell-cell adhesion (GO:0090136)2.77188814
61skin morphogenesis (GO:0043589)2.77037424
62positive regulation of fatty acid oxidation (GO:0046321)2.77036808
63hemidesmosome assembly (GO:0031581)2.76397216
64cGMP-mediated signaling (GO:0019934)2.76188538
65regulation of axon extension involved in axon guidance (GO:0048841)2.76173911
66regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74477296
67Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.73348212
68regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.70958220
69positive regulation of glycogen biosynthetic process (GO:0045725)2.69341713
70bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69022365
71muscle cell migration (GO:0014812)2.68374579
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65478844
73regulation of glucose import in response to insulin stimulus (GO:2001273)2.65034773
74cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.64824448
75wound healing, spreading of epidermal cells (GO:0035313)2.64515991
76hippo signaling (GO:0035329)2.63823457
77positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.63775492
78head development (GO:0060322)2.63641238
79negative regulation of fatty acid transport (GO:2000192)2.62320712
80plasma membrane repair (GO:0001778)2.62002789
81regulation of fatty acid beta-oxidation (GO:0031998)2.61606500
82regulation of establishment of planar polarity (GO:0090175)2.61406150
83positive regulation of receptor recycling (GO:0001921)2.61351625
84stress fiber assembly (GO:0043149)2.60504437
85protein localization to endosome (GO:0036010)2.59868128
86substrate-dependent cell migration (GO:0006929)2.59023393
87regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.58725266
88negative regulation of nitric-oxide synthase activity (GO:0051001)2.58624755
89trabecula formation (GO:0060343)2.58572223
90establishment of apical/basal cell polarity (GO:0035089)2.58271450
91positive regulation of Rho protein signal transduction (GO:0035025)2.57568254
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.56645183
93mesodermal cell differentiation (GO:0048333)2.56098085
94endothelial cell morphogenesis (GO:0001886)2.54590362
95chondrocyte proliferation (GO:0035988)2.53643223
96cell-matrix adhesion (GO:0007160)2.52772212
97negative regulation of chondrocyte differentiation (GO:0032331)2.51532958
98establishment of monopolar cell polarity (GO:0061162)2.50005786
99establishment or maintenance of monopolar cell polarity (GO:0061339)2.50005786
100lymphangiogenesis (GO:0001946)2.49169084
101chondrocyte development (GO:0002063)2.49046587
102organ induction (GO:0001759)2.46619947
103cell migration involved in sprouting angiogenesis (GO:0002042)2.45962305
104glial cell migration (GO:0008347)2.45746511
105non-canonical Wnt signaling pathway (GO:0035567)2.45687665
106myofibril assembly (GO:0030239)2.45375777
107vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.44985781
108adhesion of symbiont to host cell (GO:0044650)2.44963540
109virion attachment to host cell (GO:0019062)2.44963540
110positive regulation of osteoblast proliferation (GO:0033690)2.44051410
111myelination in peripheral nervous system (GO:0022011)2.43825336
112peripheral nervous system axon ensheathment (GO:0032292)2.43825336
113regulation of cartilage development (GO:0061035)2.43489117
114positive regulation of fatty acid beta-oxidation (GO:0032000)2.42585779
115regulation of axon guidance (GO:1902667)2.41031642
116positive regulation of endothelial cell differentiation (GO:0045603)2.40508405
117regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.39985989
118substrate adhesion-dependent cell spreading (GO:0034446)2.39708832
119outer ear morphogenesis (GO:0042473)2.39584395
120triglyceride catabolic process (GO:0019433)2.38648219
121mammary gland development (GO:0030879)2.38312604
122membrane protein ectodomain proteolysis (GO:0006509)2.37813233
123lymph vessel development (GO:0001945)2.37410821
124cell-substrate adhesion (GO:0031589)2.37335406
125negative regulation of cartilage development (GO:0061037)2.36933034
126wound healing, spreading of cells (GO:0044319)2.36208876
127nephron tubule development (GO:0072080)2.35636108
128renal tubule morphogenesis (GO:0061333)2.35241826
129smooth muscle tissue development (GO:0048745)2.35133089
130chemical homeostasis within a tissue (GO:0048875)2.35054984
131extracellular matrix organization (GO:0030198)2.34327268
132positive regulation of axon extension (GO:0045773)2.33214023
133extracellular structure organization (GO:0043062)2.33101652
134regulation of p38MAPK cascade (GO:1900744)2.32014391
135cell communication involved in cardiac conduction (GO:0086065)2.30137558
136embryonic skeletal joint morphogenesis (GO:0060272)2.29640420
137establishment of nucleus localization (GO:0040023)2.29351643
138artery development (GO:0060840)2.27916204
139lung-associated mesenchyme development (GO:0060484)2.27849123
140skin development (GO:0043588)2.26928844
141cell-substrate junction assembly (GO:0007044)2.26393623
142negative regulation of embryonic development (GO:0045992)2.26330080
143apoptotic cell clearance (GO:0043277)2.25703394
144negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.25292082
145cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.24845708
146anatomical structure regression (GO:0060033)2.24833220
147epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.24688416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.91841451
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.02664629
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.88770528
4CLOCK_20551151_ChIP-Seq_293T_Human2.64951627
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59039986
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.42373116
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38752440
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18400731
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18400731
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13854337
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.12357177
12* EP300_21415370_ChIP-Seq_HL-1_Mouse2.11333188
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09715116
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.05687493
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.03577980
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91693148
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.91547349
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91291958
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.90499193
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89450930
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87603232
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87130460
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79537627
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78211312
25* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77938669
26EZH2_22144423_ChIP-Seq_EOC_Human1.75914270
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72421601
28DROSHA_22980978_ChIP-Seq_HELA_Human1.72020593
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.68379367
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59590500
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57927274
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55738463
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55193320
34CJUN_26792858_Chip-Seq_BT549_Human1.54075673
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48957477
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48116129
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47376488
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47314658
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46946239
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46923866
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46846737
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.45821331
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44226197
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44226197
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.42463575
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.42134470
47ZNF263_19887448_ChIP-Seq_K562_Human1.42087683
48AHR_22903824_ChIP-Seq_MCF-7_Human1.40823524
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.39613473
50KDM2B_26808549_Chip-Seq_K562_Human1.39154938
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37995170
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.37746952
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35796311
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35447604
55* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35436591
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34935041
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34622734
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33794541
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32716547
60TBX20_22080862_ChIP-Seq_HEART_Mouse1.31247159
61TBX20_22328084_ChIP-Seq_HEART_Mouse1.31247159
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29560412
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29115118
64* BRD4_25478319_ChIP-Seq_HGPS_Human1.28830732
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28459437
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.26606652
67SMC1_22415368_ChIP-Seq_MEFs_Mouse1.26153688
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25518992
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25502958
70AR_21572438_ChIP-Seq_LNCaP_Human1.25146891
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23474513
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23444437
73* ARNT_22903824_ChIP-Seq_MCF-7_Human1.22223679
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.20051692
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.19631178
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19350688
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19296539
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19071215
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.15159628
80TP53_23651856_ChIP-Seq_MEFs_Mouse1.13982870
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.13434156
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13187121
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11225803
84TP53_18474530_ChIP-ChIP_U2OS_Human1.11068349
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10793769
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10727840
87NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10527113
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10375702
89TP53_22127205_ChIP-Seq_IMR90_Human1.09946353
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.09018667
91SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08991975
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08504274
93SA1_22415368_ChIP-Seq_MEFs_Mouse1.07561974
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07001615
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06886535
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06109940
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.05937094
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.05891883
99RACK7_27058665_Chip-Seq_MCF-7_Human1.05559481
100* LXR_22292898_ChIP-Seq_THP-1_Human1.04157540
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03427470
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02385190
103* ELK3_25401928_ChIP-Seq_HUVEC_Human1.01863653
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01560465
105* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00909813
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.00678195
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.00581195
108SOX2_20726797_ChIP-Seq_SW620_Human1.00420162
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99803454
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99639914
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98972525
112WT1_19549856_ChIP-ChIP_CCG9911_Human0.98956838
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97453010
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97099226
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97059620
116GBX2_23144817_ChIP-Seq_PC3_Human0.96884982
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96374013
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95707861
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95444656
120IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95359443
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.95012349
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94776291
123* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94647975
124* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94139679
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93759191
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93715582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.91763094
2MP0005275_abnormal_skin_tensile4.97265843
3MP0004272_abnormal_basement_membrane4.23709765
4MP0001958_emphysema3.64575508
5MP0005503_abnormal_tendon_morphology3.53660961
6MP0003705_abnormal_hypodermis_morpholog3.24238174
7MP0000751_myopathy3.13994976
8MP0003279_aneurysm2.40492147
9MP0006054_spinal_hemorrhage2.21037546
10MP0000537_abnormal_urethra_morphology2.02251403
11MP0003122_maternal_imprinting1.91862110
12MP0002060_abnormal_skin_morphology1.80837951
13MP0005623_abnormal_meninges_morphology1.73427444
14MP0002837_dystrophic_cardiac_calcinosis1.68228325
15MP0004858_abnormal_nervous_system1.66577848
16MP0010368_abnormal_lymphatic_system1.64859387
17MP0000534_abnormal_ureter_morphology1.62909761
18MP0004084_abnormal_cardiac_muscle1.59505279
19MP0003566_abnormal_cell_adhesion1.54151564
20MP0002877_abnormal_melanocyte_morpholog1.53236869
21MP0003950_abnormal_plasma_membrane1.51365075
22MP0000767_abnormal_smooth_muscle1.50944433
23MP0002108_abnormal_muscle_morphology1.50427967
24MP0003385_abnormal_body_wall1.48147623
25MP0000467_abnormal_esophagus_morphology1.47994451
26MP0000462_abnormal_digestive_system1.47655656
27MP0005508_abnormal_skeleton_morphology1.45182738
28MP0005409_darkened_coat_color1.42804902
29MP0000013_abnormal_adipose_tissue1.42390252
30MP0001879_abnormal_lymphatic_vessel1.40916065
31MP0006138_congestive_heart_failure1.40057620
32MP0010234_abnormal_vibrissa_follicle1.36615193
33MP0004130_abnormal_muscle_cell1.30659928
34MP0009780_abnormal_chondrocyte_physiolo1.26519609
35MP0002896_abnormal_bone_mineralization1.25949677
36MP0010030_abnormal_orbit_morphology1.22862314
37MP0002295_abnormal_pulmonary_circulatio1.22721345
38MP0000750_abnormal_muscle_regeneration1.20655985
39MP0003115_abnormal_respiratory_system1.19934221
40MP0002822_catalepsy1.18203009
41MP0003942_abnormal_urinary_system1.17923565
42MP0004484_altered_response_of1.17872507
43MP0005076_abnormal_cell_differentiation1.17824667
44MP0008775_abnormal_heart_ventricle1.17086335
45MP0005385_cardiovascular_system_phenoty1.16920317
46MP0001544_abnormal_cardiovascular_syste1.16920317
47MP0004087_abnormal_muscle_fiber1.16616862
48MP0000759_abnormal_skeletal_muscle1.16419685
49MP0009053_abnormal_anal_canal1.15133486
50MP0000003_abnormal_adipose_tissue1.14534951
51MP0003283_abnormal_digestive_organ1.10103285
52MP0005666_abnormal_adipose_tissue1.10080760
53MP0001348_abnormal_lacrimal_gland1.09996114
54MP0005187_abnormal_penis_morphology1.09405373
55MP0002972_abnormal_cardiac_muscle1.09273095
56MP0004185_abnormal_adipocyte_glucose1.08959165
57MP0005620_abnormal_muscle_contractility1.07533702
58MP0009250_abnormal_appendicular_skeleto1.06979510
59MP0004215_abnormal_myocardial_fiber1.06120634
60MP0005375_adipose_tissue_phenotype1.06094790
61MP0003045_fibrosis1.05836982
62MP0009384_cardiac_valve_regurgitation1.05519891
63MP0002089_abnormal_postnatal_growth/wei1.05138099
64MP0005367_renal/urinary_system_phenotyp1.02500326
65MP0000516_abnormal_urinary_system1.02500326
66MP0001299_abnormal_eye_distance/1.01102917
67MP0000749_muscle_degeneration0.99635530
68MP0005595_abnormal_vascular_smooth0.99032093
69MP0005330_cardiomyopathy0.98865729
70MP0002971_abnormal_brown_adipose0.98643550
71MP0003123_paternal_imprinting0.97958697
72MP0000579_abnormal_nail_morphology0.97054258
73MP0003941_abnormal_skin_development0.96373029
74MP0003300_gastrointestinal_ulcer0.94986500
75MP0001243_abnormal_dermal_layer0.92865206
76MP0002138_abnormal_hepatobiliary_system0.92250373
77MP0004036_abnormal_muscle_relaxation0.92234258
78MP0010352_gastrointestinal_tract_polyps0.91746537
79MP0005670_abnormal_white_adipose0.91616038
80MP0000428_abnormal_craniofacial_morphol0.91304493
81MP0003453_abnormal_keratinocyte_physiol0.91085478
82MP0004883_abnormal_blood_vessel0.90864304
83MP0000733_abnormal_muscle_development0.90817890
84MP0001661_extended_life_span0.89598151
85MP0005388_respiratory_system_phenotype0.89263421
86MP0002133_abnormal_respiratory_system0.89263421
87MP0001177_atelectasis0.89245176
88MP0005257_abnormal_intraocular_pressure0.89183409
89MP0010630_abnormal_cardiac_muscle0.88803308
90MP0003191_abnormal_cellular_cholesterol0.86788651
91MP0003567_abnormal_fetal_cardiomyocyte0.85457142
92MP0002282_abnormal_trachea_morphology0.85322917
93MP0000762_abnormal_tongue_morphology0.85066620
94MP0005164_abnormal_response_to0.84424667
95MP0003091_abnormal_cell_migration0.82450983
96MP0002115_abnormal_skeleton_extremities0.82336352
97MP0004085_abnormal_heartbeat0.82277962
98MP0002128_abnormal_blood_circulation0.82144429
99MP0005165_increased_susceptibility_to0.81043315
100MP0002796_impaired_skin_barrier0.80941071
101MP0002932_abnormal_joint_morphology0.80089355
102MP0000163_abnormal_cartilage_morphology0.80088665
103MP0003828_pulmonary_edema0.79960564
104MP0003755_abnormal_palate_morphology0.79428247
105MP0002925_abnormal_cardiovascular_devel0.79138132
106MP0005369_muscle_phenotype0.78999436
107MP0001849_ear_inflammation0.78259393
108MP0001542_abnormal_bone_strength0.77577960
109MP0002106_abnormal_muscle_physiology0.75197786
110MP0005023_abnormal_wound_healing0.75117579
111MP0005390_skeleton_phenotype0.75038624
112MP0001614_abnormal_blood_vessel0.74939086
113MP0009278_abnormal_bone_marrow0.74757934
114MP0003137_abnormal_impulse_conducting0.74666470
115MP0004233_abnormal_muscle_weight0.73703260
116MP0001756_abnormal_urination0.72514571
117MP0003935_abnormal_craniofacial_develop0.72379962
118MP0003959_abnormal_lean_body0.72042204
119MP0002249_abnormal_larynx_morphology0.71990584
120MP0000432_abnormal_head_morphology0.71957928
121MP0002116_abnormal_craniofacial_bone0.70875918
122MP0004145_abnormal_muscle_electrophysio0.70833485
123MP0000566_synostosis0.70316576
124MP0005197_abnormal_uvea_morphology0.67188018

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)6.29725708
2Type 1 muscle fiber predominance (HP:0003803)5.38027286
3Follicular hyperkeratosis (HP:0007502)5.19073905
4Protrusio acetabuli (HP:0003179)4.90210083
5Premature rupture of membranes (HP:0001788)4.84721465
6Broad metatarsal (HP:0001783)4.80500148
7Atrophic scars (HP:0001075)4.68440398
8Aortic dissection (HP:0002647)4.51510603
9Increased connective tissue (HP:0009025)4.23598859
10Cerebral aneurysm (HP:0004944)4.17994627
11Slender build (HP:0001533)4.13231764
12Increased variability in muscle fiber diameter (HP:0003557)4.12454707
13Shallow orbits (HP:0000586)3.95062107
14Fragile skin (HP:0001030)3.89825881
15Bladder diverticulum (HP:0000015)3.84631353
16Vascular tortuosity (HP:0004948)3.72329614
17Mildly elevated creatine phosphokinase (HP:0008180)3.63416726
18Arterial tortuosity (HP:0005116)3.56581618
19Abnormality of skeletal muscle fiber size (HP:0012084)3.50075363
20Spinal rigidity (HP:0003306)3.49513298
21Soft skin (HP:0000977)3.38555634
22Mitral valve prolapse (HP:0001634)3.31359394
23Aortic aneurysm (HP:0004942)3.20231691
24Dilatation of the ascending aorta (HP:0005111)3.05217794
25Wrist flexion contracture (HP:0001239)2.90819433
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.83854093
27Short 4th metacarpal (HP:0010044)2.83854093
28Renovascular hypertension (HP:0100817)2.82143230
29Right ventricular cardiomyopathy (HP:0011663)2.80549632
30Striae distensae (HP:0001065)2.78285545
31Hypoventilation (HP:0002791)2.78207999
32Vertebral compression fractures (HP:0002953)2.78110130
33Abnormality of the 4th metacarpal (HP:0010012)2.74870005
34Venous insufficiency (HP:0005293)2.72318539
35Muscle fiber splitting (HP:0003555)2.67201286
36Renal duplication (HP:0000075)2.56264211
37Venous abnormality (HP:0002624)2.52133711
38Peritonitis (HP:0002586)2.50105780
39Ulnar bowing (HP:0003031)2.49297029
40Broad face (HP:0000283)2.49285208
41Short nail (HP:0001799)2.45889203
42Lymphangioma (HP:0100764)2.45673306
43Bowel diverticulosis (HP:0005222)2.42385247
44Neonatal short-limb short stature (HP:0008921)2.40958099
45Flat cornea (HP:0007720)2.40291856
46Pterygium (HP:0001059)2.39281107
47Hyperextensible skin (HP:0000974)2.35116344
48Alopecia of scalp (HP:0002293)2.34575820
49Deviation of the hallux (HP:0010051)2.30506708
50Narrow nasal bridge (HP:0000446)2.29455457
51Natal tooth (HP:0000695)2.29020781
52Limb-girdle muscle weakness (HP:0003325)2.28638863
53Elfin facies (HP:0004428)2.27645748
54Aneurysm (HP:0002617)2.24049691
55Short hallux (HP:0010109)2.23706957
56Joint laxity (HP:0001388)2.23307615
57Hyperacusis (HP:0010780)2.22536294
58Bone cyst (HP:0012062)2.19223396
59Hallux valgus (HP:0001822)2.15961379
60Blue sclerae (HP:0000592)2.12978345
61Long toe (HP:0010511)2.12431153
62Mitral stenosis (HP:0001718)2.12316577
63Genu recurvatum (HP:0002816)2.10564237
64Pulmonary artery stenosis (HP:0004415)2.09949194
65Abnormality of dentin (HP:0010299)2.06261854
66Elbow flexion contracture (HP:0002987)2.03650974
67Thin bony cortex (HP:0002753)2.03415926
68Abnormal ossification of hand bones (HP:0005921)2.03369330
69Aplasia/Hypoplasia of the hallux (HP:0008362)2.02579572
70Milia (HP:0001056)2.02145971
71Wormian bones (HP:0002645)2.01372334
72Back pain (HP:0003418)2.00836305
73Selective tooth agenesis (HP:0001592)2.00635091
74Generalized amyotrophy (HP:0003700)1.99263470
75Gingival overgrowth (HP:0000212)1.98804872
76Spondylolisthesis (HP:0003302)1.98794635
77Sudden death (HP:0001699)1.98627404
78Advanced eruption of teeth (HP:0006288)1.97475695
79Abnormality of carpal bone ossification (HP:0006257)1.96205589
80Fragile nails (HP:0001808)1.96141031
81Spinal cord lesions (HP:0100561)1.95971629
82Syringomyelia (HP:0003396)1.95971629
83Wide anterior fontanel (HP:0000260)1.95159405
84Turricephaly (HP:0000262)1.94861740
85Camptodactyly of toe (HP:0001836)1.92691644
86Biconcave vertebral bodies (HP:0004586)1.91836748
87Protruding ear (HP:0000411)1.91139720
88Hypercalcemia (HP:0003072)1.91039588
89Hypoplasia of the iris (HP:0007676)1.91036986
90Buphthalmos (HP:0000557)1.90865992
91Distal lower limb amyotrophy (HP:0008944)1.90408766
92Ectopia lentis (HP:0001083)1.90231648
93Acanthosis nigricans (HP:0000956)1.89223368
94Cervical subluxation (HP:0003308)1.88686776
95Round ear (HP:0100830)1.88650021
96Overgrowth (HP:0001548)1.87662488
97Aortic regurgitation (HP:0001659)1.87181607
98Abnormal delivery (HP:0001787)1.86946249
99Trismus (HP:0000211)1.86851087
100Hepatoblastoma (HP:0002884)1.85904156
101Hip contracture (HP:0003273)1.85062210
102Distal lower limb muscle weakness (HP:0009053)1.84247316
103Aortic valve stenosis (HP:0001650)1.83185971
104Asymmetry of the thorax (HP:0001555)1.82939441
105Osteolytic defects of the phalanges of the hand (HP:0009771)1.81806248
106Osteolytic defects of the hand bones (HP:0009699)1.81806248
107Abnormality of the distal phalanx of the thumb (HP:0009617)1.78699043
108Mitral regurgitation (HP:0001653)1.77886591
109Torticollis (HP:0000473)1.76860295
110Coronal craniosynostosis (HP:0004440)1.76023618
111Abnormality of the distal phalanges of the toes (HP:0010182)1.75424022
112Overriding aorta (HP:0002623)1.75370588
113Coxa vara (HP:0002812)1.75155397
114Osteoarthritis (HP:0002758)1.75133126
115Cupped ribs (HP:0000887)1.74682461
116Hematochezia (HP:0002573)1.73477117
117Rectal prolapse (HP:0002035)1.72837956
118Asymmetric septal hypertrophy (HP:0001670)1.71946814
119Thin ribs (HP:0000883)1.69964495
120Neoplasm of the heart (HP:0100544)1.68975841
121Infantile muscular hypotonia (HP:0008947)1.68428246
122Absent frontal sinuses (HP:0002688)1.68284959
123Abnormality of the acetabulum (HP:0003170)1.67683932
124Obstructive sleep apnea (HP:0002870)1.66832030
125Vertebral arch anomaly (HP:0008438)1.66521566
126Disproportionate tall stature (HP:0001519)1.66520971
127Ventricular tachycardia (HP:0004756)1.66478320
128Centrally nucleated skeletal muscle fibers (HP:0003687)1.64633677
129Bradycardia (HP:0001662)1.64008452
130Osteopenia (HP:0000938)1.63668628
131Abnormality of the calcaneus (HP:0008364)1.62576672
132Knee flexion contracture (HP:0006380)1.62451624
133Bronchomalacia (HP:0002780)1.62110030
134Humeroradial synostosis (HP:0003041)1.61569735
135Synostosis involving the elbow (HP:0003938)1.61569735
136Mesomelia (HP:0003027)1.60576205
137Lipoatrophy (HP:0100578)1.59719904
138Midline defect of the nose (HP:0004122)1.59130507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDGFRA3.66711108
2MYLK3.47860471
3TRIB33.31244465
4EPHB23.14062972
5RIPK12.88185763
6TTN2.87111123
7LMTK22.75621915
8TIE12.71200679
9DDR22.66171562
10LATS22.31900266
11EPHA22.22675320
12LATS12.18838472
13TGFBR22.00859762
14FER1.94562928
15SIK11.91179279
16PKN21.86968818
17DMPK1.83683062
18PHKG11.65616949
19PHKG21.65616949
20PDK41.62042173
21PDK31.62042173
22PTK61.57796451
23PDGFRB1.47102328
24FGFR41.46546172
25WNK41.45458282
26ERN11.43012977
27MAP3K61.41982862
28TRPM71.40126707
29PAK21.35579279
30MST1R1.30574741
31CDK121.30062117
32SMG11.29943856
33NTRK11.28406914
34EPHA31.25267252
35PRPF4B1.20922164
36FGFR21.19904382
37PIK3CA1.18603688
38FRK1.18415212
39MARK11.16989394
40MET1.14406636
41MOS1.13935108
42DAPK21.13188005
43PTK21.12854628
44EPHB11.10436359
45RET1.09624665
46BMX1.09219979
47MAP3K101.03748446
48PRKD21.00866280
49PAK40.99613630
50CDC42BPA0.98395304
51ARAF0.95793205
52KIT0.95225676
53ROCK10.94144028
54FGFR10.94061519
55DAPK30.93613517
56KSR20.89449465
57PAK30.88352815
58ILK0.87818296
59MAP2K10.87476371
60STK38L0.86165073
61CAMK1D0.86113524
62PDK20.83249516
63CAMK1G0.82825015
64IRAK30.81907329
65MAP3K90.71556769
66PTK2B0.70405929
67WNK10.70153254
68MAP3K70.68993248
69EEF2K0.67777627
70MTOR0.66210850
71RPS6KA20.65093315
72GSK3A0.63774198
73OBSCN0.63547500
74MAPK70.63160351
75PRKD10.61158400
76CLK10.60993908
77FGFR30.59974641
78MAPKAPK30.59879178
79MAP3K20.59577652
80LIMK10.57956832
81PRKD30.57296311
82PRKCH0.57112777
83CDK90.56777207
84MAP2K40.55788177
85TGFBR10.55332669
86ADRBK10.55261923
87LRRK20.53907847
88NEK10.52886875
89ERBB20.52719461
90PRKCI0.52457020
91NEK90.52202699
92MAP3K40.51913897
93SRC0.51132455
94MINK10.50342173
95PRKCE0.50229533
96BCKDK0.50072392
97PRKAA20.49870168
98RPS6KC10.49758870
99RPS6KL10.49758870
100KSR10.48978284
101TYRO30.48881176
102MAPK150.47771354
103ICK0.47680362
104JAK10.47597555
105MAP2K20.47428650
106ROCK20.47292570
107FLT30.45937308
108STK30.45235534
109STK380.45209739
110STK390.43494237
111CDK60.43256199
112PIM20.41993756
113PAK60.41790730
114CAMKK10.41414069
115STK240.40795974
116CDK80.40238265
117SCYL20.39004485
118TESK10.38096209
119PRKAA10.38043221
120MARK20.37218139
121MAP3K80.35774149
122MAPK40.35529870
123ERBB40.34850964
124ABL20.34556318
125PRKG20.33371169
126MUSK0.33069182
127MAP3K30.31780324
128RPS6KA60.29738885
129MELK0.26833169
130CAMK2D0.26553767
131AKT20.26445747
132CAMK2G0.25275493
133MAP3K10.25155942
134INSR0.23469564
135HIPK20.22323828

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.52065756
2Protein digestion and absorption_Homo sapiens_hsa049743.42591405
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.62212791
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43549792
5Focal adhesion_Homo sapiens_hsa045102.34997901
6Dilated cardiomyopathy_Homo sapiens_hsa054141.88457784
7Amoebiasis_Homo sapiens_hsa051461.87617585
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81471764
9Basal cell carcinoma_Homo sapiens_hsa052171.81148193
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71328507
11Hedgehog signaling pathway_Homo sapiens_hsa043401.61045440
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60366657
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56899112
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43050383
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42472741
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38941172
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38856827
18Hippo signaling pathway_Homo sapiens_hsa043901.36842334
19Proteoglycans in cancer_Homo sapiens_hsa052051.34275191
20Adherens junction_Homo sapiens_hsa045201.31491208
21Axon guidance_Homo sapiens_hsa043601.23653152
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21558001
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20834346
24Tight junction_Homo sapiens_hsa045301.20507649
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.17163645
26Dorso-ventral axis formation_Homo sapiens_hsa043201.16823178
27Propanoate metabolism_Homo sapiens_hsa006401.15964839
28Small cell lung cancer_Homo sapiens_hsa052221.14543474
29Prion diseases_Homo sapiens_hsa050201.13695810
30Renin secretion_Homo sapiens_hsa049241.12598650
31Viral myocarditis_Homo sapiens_hsa054161.07842773
32Fatty acid degradation_Homo sapiens_hsa000711.07786485
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04187735
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02662455
35Gastric acid secretion_Homo sapiens_hsa049711.02520012
36Estrogen signaling pathway_Homo sapiens_hsa049151.01427909
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00533645
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.00140020
39Melanogenesis_Homo sapiens_hsa049160.99554490
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.97466664
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96358213
42Gap junction_Homo sapiens_hsa045400.96108955
43PPAR signaling pathway_Homo sapiens_hsa033200.94979467
44Endometrial cancer_Homo sapiens_hsa052130.94572766
45Thyroid cancer_Homo sapiens_hsa052160.93530137
46Fatty acid metabolism_Homo sapiens_hsa012120.92004220
47Renin-angiotensin system_Homo sapiens_hsa046140.90009389
48Insulin resistance_Homo sapiens_hsa049310.89679854
49Melanoma_Homo sapiens_hsa052180.88775105
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87861201
51Pyruvate metabolism_Homo sapiens_hsa006200.87127238
52Pathways in cancer_Homo sapiens_hsa052000.84330262
53Glioma_Homo sapiens_hsa052140.84299991
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84276865
55Bile secretion_Homo sapiens_hsa049760.83979096
56Malaria_Homo sapiens_hsa051440.83656969
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82983959
58Thyroid hormone synthesis_Homo sapiens_hsa049180.82525835
59Type II diabetes mellitus_Homo sapiens_hsa049300.82433457
60Phenylalanine metabolism_Homo sapiens_hsa003600.82339818
61Rap1 signaling pathway_Homo sapiens_hsa040150.81805925
62Salivary secretion_Homo sapiens_hsa049700.80989017
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.80896331
64Bladder cancer_Homo sapiens_hsa052190.79383051
65TGF-beta signaling pathway_Homo sapiens_hsa043500.79102607
66Toxoplasmosis_Homo sapiens_hsa051450.77448718
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76595602
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.76548123
69Butanoate metabolism_Homo sapiens_hsa006500.75291066
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74508712
71ErbB signaling pathway_Homo sapiens_hsa040120.73646998
72GnRH signaling pathway_Homo sapiens_hsa049120.73600148
73AMPK signaling pathway_Homo sapiens_hsa041520.72992021
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72282224
75Insulin signaling pathway_Homo sapiens_hsa049100.71455140
76MicroRNAs in cancer_Homo sapiens_hsa052060.70297917
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70182762
78Notch signaling pathway_Homo sapiens_hsa043300.69667274
79Platelet activation_Homo sapiens_hsa046110.69452764
80Wnt signaling pathway_Homo sapiens_hsa043100.69073469
81Acute myeloid leukemia_Homo sapiens_hsa052210.68705140
82mTOR signaling pathway_Homo sapiens_hsa041500.68012853
83Non-small cell lung cancer_Homo sapiens_hsa052230.67888606
84Fatty acid biosynthesis_Homo sapiens_hsa000610.66783847
85cAMP signaling pathway_Homo sapiens_hsa040240.64931170
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64383602
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63501283
88Oxytocin signaling pathway_Homo sapiens_hsa049210.62856169
89Colorectal cancer_Homo sapiens_hsa052100.62640550
90Circadian entrainment_Homo sapiens_hsa047130.62529288
91Renal cell carcinoma_Homo sapiens_hsa052110.62393061
92Choline metabolism in cancer_Homo sapiens_hsa052310.62313075
93Fat digestion and absorption_Homo sapiens_hsa049750.60171855
94Cardiac muscle contraction_Homo sapiens_hsa042600.59819028
95VEGF signaling pathway_Homo sapiens_hsa043700.59797421
96Other glycan degradation_Homo sapiens_hsa005110.57141559
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56908832
98Carbon metabolism_Homo sapiens_hsa012000.56887208
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55649670
100Ovarian steroidogenesis_Homo sapiens_hsa049130.55434689
101Glycerolipid metabolism_Homo sapiens_hsa005610.54157202
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54027075
103Mineral absorption_Homo sapiens_hsa049780.52562700
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51425518
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.51387037
106Pancreatic secretion_Homo sapiens_hsa049720.51059218
107Vitamin B6 metabolism_Homo sapiens_hsa007500.50535138
108Chronic myeloid leukemia_Homo sapiens_hsa052200.50506473
109Fatty acid elongation_Homo sapiens_hsa000620.50155847
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49545670
111Endocytosis_Homo sapiens_hsa041440.49289523
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48727343
113Pancreatic cancer_Homo sapiens_hsa052120.47477391
114N-Glycan biosynthesis_Homo sapiens_hsa005100.47457409
115Prolactin signaling pathway_Homo sapiens_hsa049170.46964716
116Taste transduction_Homo sapiens_hsa047420.46745814
117Glucagon signaling pathway_Homo sapiens_hsa049220.46256245
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.45880954
119Lysine degradation_Homo sapiens_hsa003100.45657474
120beta-Alanine metabolism_Homo sapiens_hsa004100.45289145
121Prostate cancer_Homo sapiens_hsa052150.45244375
122Galactose metabolism_Homo sapiens_hsa000520.44654362
123Cholinergic synapse_Homo sapiens_hsa047250.44212022
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42958103
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42068369
126Ras signaling pathway_Homo sapiens_hsa040140.41580729
127Inositol phosphate metabolism_Homo sapiens_hsa005620.39838830

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