ADAMTS16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)5.02169684
2membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.52584894
3mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.30110587
4detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.22977049
5regulation of posttranscriptional gene silencing (GO:0060147)4.19235564
6regulation of gene silencing by miRNA (GO:0060964)4.19235564
7regulation of gene silencing by RNA (GO:0060966)4.19235564
8response to pheromone (GO:0019236)4.08806335
9membrane repolarization during action potential (GO:0086011)4.03700810
10negative regulation of axon guidance (GO:1902668)3.82969111
11neural tube formation (GO:0001841)3.73006727
12dopaminergic neuron differentiation (GO:0071542)3.66444685
13photoreceptor cell maintenance (GO:0045494)3.63632532
14regulation of axon guidance (GO:1902667)3.59609620
15cell proliferation involved in metanephros development (GO:0072203)3.57646486
16behavioral response to ethanol (GO:0048149)3.45700485
17indolalkylamine metabolic process (GO:0006586)3.41929383
18presynaptic membrane assembly (GO:0097105)3.40186122
19negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.39809522
20establishment of nucleus localization (GO:0040023)3.37076179
21atrial cardiac muscle cell action potential (GO:0086014)3.36391368
22negative regulation of axon extension involved in axon guidance (GO:0048843)3.36092597
23synaptic vesicle maturation (GO:0016188)3.35350864
24cornea development in camera-type eye (GO:0061303)3.34898933
25cell-cell junction maintenance (GO:0045217)3.33083089
26membrane repolarization (GO:0086009)3.32100691
27lung epithelium development (GO:0060428)3.31936476
28regulation of hippo signaling (GO:0035330)3.30779332
29axon extension involved in axon guidance (GO:0048846)3.29651480
30neuron projection extension involved in neuron projection guidance (GO:1902284)3.29651480
31regulation of axon extension involved in axon guidance (GO:0048841)3.28369114
32behavioral response to nicotine (GO:0035095)3.27300401
33inner ear receptor stereocilium organization (GO:0060122)3.23670365
34vocalization behavior (GO:0071625)3.23651718
35glomerular basement membrane development (GO:0032836)3.21787013
36protein K11-linked deubiquitination (GO:0035871)3.17797006
37indolalkylamine catabolic process (GO:0046218)3.15691267
38tryptophan catabolic process (GO:0006569)3.15691267
39indole-containing compound catabolic process (GO:0042436)3.15691267
40retinal cone cell development (GO:0046549)3.15209134
41positive regulation of potassium ion transmembrane transport (GO:1901381)3.13815079
42signal peptide processing (GO:0006465)3.10088966
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08386607
44positive regulation of gastrulation (GO:2000543)3.07717576
45C4-dicarboxylate transport (GO:0015740)3.03225036
46detection of light stimulus involved in sensory perception (GO:0050962)3.00692559
47detection of light stimulus involved in visual perception (GO:0050908)3.00692559
48central nervous system myelination (GO:0022010)2.98813914
49axon ensheathment in central nervous system (GO:0032291)2.98813914
50layer formation in cerebral cortex (GO:0021819)2.98784674
51tachykinin receptor signaling pathway (GO:0007217)2.98272963
52axonal fasciculation (GO:0007413)2.98074235
53regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.97911246
54water-soluble vitamin biosynthetic process (GO:0042364)2.97779059
55locomotory exploration behavior (GO:0035641)2.97658144
56presynaptic membrane organization (GO:0097090)2.95089489
57regulation of chemokine-mediated signaling pathway (GO:0070099)2.93035975
58kidney morphogenesis (GO:0060993)2.92919687
59positive regulation of oligodendrocyte differentiation (GO:0048714)2.92597473
60cell proliferation involved in kidney development (GO:0072111)2.91500948
61reflex (GO:0060004)2.91065804
62regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90878396
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88275662
64nephron epithelium morphogenesis (GO:0072088)2.85962550
65nephron tubule morphogenesis (GO:0072078)2.85962550
66positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.85729112
67primitive streak formation (GO:0090009)2.85472656
68potassium ion export (GO:0071435)2.83501750
69prenylation (GO:0097354)2.82881353
70protein prenylation (GO:0018342)2.82881353
71negative regulation of axon extension (GO:0030517)2.82356127
72glomerular epithelial cell development (GO:0072310)2.81964525
73kynurenine metabolic process (GO:0070189)2.80500089
74neuron recognition (GO:0008038)2.80102784
75response to auditory stimulus (GO:0010996)2.78905295
76regulation of meiosis I (GO:0060631)2.78342672
77regulation of mesenchymal cell apoptotic process (GO:2001053)2.77990059
78auditory receptor cell stereocilium organization (GO:0060088)2.77349335
79detection of mechanical stimulus involved in sensory perception (GO:0050974)2.76923825
80L-fucose catabolic process (GO:0042355)2.76225137
81fucose catabolic process (GO:0019317)2.76225137
82L-fucose metabolic process (GO:0042354)2.76225137
83branching involved in salivary gland morphogenesis (GO:0060445)2.74619524
84response to nitrosative stress (GO:0051409)2.73027072
85cilium morphogenesis (GO:0060271)2.72752868
86cellular ketone body metabolic process (GO:0046950)2.71979778
87peripheral nervous system axon ensheathment (GO:0032292)2.71962751
88myelination in peripheral nervous system (GO:0022011)2.71962751
89tryptophan metabolic process (GO:0006568)2.70449290
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70290442
91regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.70108174
92outer ear morphogenesis (GO:0042473)2.69643918
93cellular response to sterol (GO:0036315)2.68843510
94lateral sprouting from an epithelium (GO:0060601)2.68787997
95synaptic vesicle docking involved in exocytosis (GO:0016081)2.68158991
96regulation of membrane repolarization (GO:0060306)2.67616509
97reciprocal meiotic recombination (GO:0007131)2.66529758
98reciprocal DNA recombination (GO:0035825)2.66529758
99cilium or flagellum-dependent cell motility (GO:0001539)2.65784098
100gamma-aminobutyric acid transport (GO:0015812)2.64882102
101neuronal action potential propagation (GO:0019227)2.64521027
102regulation of sarcomere organization (GO:0060297)2.64474069
103regulation of heart rate by cardiac conduction (GO:0086091)2.62598288
104cilium organization (GO:0044782)2.62511560
105dendritic spine morphogenesis (GO:0060997)2.60424358
106ketone body metabolic process (GO:1902224)2.59492467
107amino acid salvage (GO:0043102)2.58846267
108L-methionine salvage (GO:0071267)2.58846267
109L-methionine biosynthetic process (GO:0071265)2.58846267
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58333305
111nonmotile primary cilium assembly (GO:0035058)2.58164662
112mesenchymal to epithelial transition (GO:0060231)2.57144625
113replication fork processing (GO:0031297)2.56793862
114cilium assembly (GO:0042384)2.56778995
115cellular biogenic amine catabolic process (GO:0042402)2.56751784
116amine catabolic process (GO:0009310)2.56751784
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56211353
118establishment of protein localization to Golgi (GO:0072600)2.56161390
119cell junction maintenance (GO:0034331)2.56022796
120indole-containing compound metabolic process (GO:0042430)2.55058614
121DNA double-strand break processing (GO:0000729)2.55044544
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54584949
123limb bud formation (GO:0060174)2.54325649
124intraciliary transport (GO:0042073)2.53993769
125dopamine transport (GO:0015872)2.53857562
126mesenchymal cell proliferation (GO:0010463)2.52657281
127renal tubule morphogenesis (GO:0061333)2.52602766
128glycosphingolipid biosynthetic process (GO:0006688)2.51998472
129piRNA metabolic process (GO:0034587)2.50454997
130startle response (GO:0001964)2.50265915
131monoubiquitinated protein deubiquitination (GO:0035520)2.49815834
132photoreceptor cell development (GO:0042461)2.49784641
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49752369
134exocrine pancreas development (GO:0031017)2.49530049
135pyrimidine nucleobase catabolic process (GO:0006208)2.48618438
136positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.48598131
137benzene-containing compound metabolic process (GO:0042537)2.48166142
138glial cell migration (GO:0008347)2.47672481
139regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.47590250
140recombinational repair (GO:0000725)2.47478319
141double-strand break repair via homologous recombination (GO:0000724)2.46804738
142epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46452311
143ionotropic glutamate receptor signaling pathway (GO:0035235)2.46320044
144glomerular filtration (GO:0003094)2.45169567
145neuromuscular process controlling balance (GO:0050885)2.44934702
146positive regulation of potassium ion transport (GO:0043268)2.44711133
147cardiac conduction (GO:0061337)2.43165524
148protein heterotrimerization (GO:0070208)2.42476327
149glutamate secretion (GO:0014047)2.42394813
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41496036
151epithelial tube formation (GO:0072175)2.41201794
152transmission of nerve impulse (GO:0019226)2.40366288
153somite development (GO:0061053)2.40239765
154acrosome assembly (GO:0001675)2.40168467
155embryonic epithelial tube formation (GO:0001838)2.39880853
156epithelial cell differentiation involved in kidney development (GO:0035850)2.38969488
157righting reflex (GO:0060013)2.38936982
158chondrocyte proliferation (GO:0035988)2.38905197
159neuroblast proliferation (GO:0007405)2.38684086
160regulation of neuron migration (GO:2001222)2.38220858
161regulation of collateral sprouting (GO:0048670)2.38208236
162cellular potassium ion homeostasis (GO:0030007)2.37924939
163regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.36734141
164negative regulation of DNA-dependent DNA replication (GO:2000104)2.36628692
165regulation of respiratory system process (GO:0044065)2.36436533
166neuronal ion channel clustering (GO:0045161)2.36416019
167nucleus localization (GO:0051647)2.35088490
168regulation of gonadotropin secretion (GO:0032276)2.34873004
169sulfation (GO:0051923)2.34580958
170microglial cell activation (GO:0001774)2.34217898
171regulation of glutamate receptor signaling pathway (GO:1900449)2.32918780
172peptidyl-tyrosine autophosphorylation (GO:0038083)2.32588128
173negative regulation of chondrocyte differentiation (GO:0032331)2.32321378
174regulation of nuclear cell cycle DNA replication (GO:0033262)2.31959253
175membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.31755947
176negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.31608776
177negative regulation of translation, ncRNA-mediated (GO:0040033)2.31608776
178regulation of translation, ncRNA-mediated (GO:0045974)2.31608776
179axoneme assembly (GO:0035082)2.31163074
180cytoskeletal anchoring at plasma membrane (GO:0007016)2.30554179
181neuronal action potential (GO:0019228)2.30329421
182methionine biosynthetic process (GO:0009086)2.29878186
183serotonin metabolic process (GO:0042428)2.29567597
184semaphorin-plexin signaling pathway (GO:0071526)2.29309587
185postsynaptic membrane organization (GO:0001941)2.29247978
186protein localization to cilium (GO:0061512)2.28600209
187neuron remodeling (GO:0016322)2.28417175
188innervation (GO:0060384)2.28014629
189metanephric mesenchyme development (GO:0072075)2.26298550
190renal filtration (GO:0097205)2.25562119
191long-term memory (GO:0007616)2.25344293
192midbrain development (GO:0030901)2.25082145
193neuron cell-cell adhesion (GO:0007158)2.24854804
194forebrain neuron differentiation (GO:0021879)2.24837579
195nephron tubule formation (GO:0072079)2.24440175
196collagen fibril organization (GO:0030199)2.23862295
197negative chemotaxis (GO:0050919)2.22701328
198cerebellar granule cell differentiation (GO:0021707)2.21684723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.18961905
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95005446
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.90501045
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89314749
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89314749
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87981913
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86445523
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.84428593
9VDR_22108803_ChIP-Seq_LS180_Human2.83485204
10GBX2_23144817_ChIP-Seq_PC3_Human2.82636149
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75871546
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75828403
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.67290386
14IGF1R_20145208_ChIP-Seq_DFB_Human2.66788345
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.61630098
16* DROSHA_22980978_ChIP-Seq_HELA_Human2.60721611
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57457518
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53063233
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45036095
20FUS_26573619_Chip-Seq_HEK293_Human2.44197992
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.40351439
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38067319
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29350751
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.28046342
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24392571
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.15238553
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11984556
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10570787
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10107467
30EWS_26573619_Chip-Seq_HEK293_Human2.09712010
31AR_21572438_ChIP-Seq_LNCaP_Human2.01024764
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95875717
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88877917
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84114681
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.77296540
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76789347
37ER_23166858_ChIP-Seq_MCF-7_Human1.76776812
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72593981
39CBP_20019798_ChIP-Seq_JUKART_Human1.71425444
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71425444
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68668530
42WT1_25993318_ChIP-Seq_PODOCYTE_Human1.66011795
43* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65791120
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64235682
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.62689288
46* TCF4_23295773_ChIP-Seq_U87_Human1.61925141
47* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59882494
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58847339
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58679900
50BCAT_22108803_ChIP-Seq_LS180_Human1.58638652
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56673790
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56467080
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55376324
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.54952745
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.52146437
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50504099
57AR_25329375_ChIP-Seq_VCAP_Human1.46648258
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43799230
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.43067229
60* PIAS1_25552417_ChIP-Seq_VCAP_Human1.42911674
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41879728
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.40595855
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.40550219
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40416083
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40333296
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40092029
67TCF4_22108803_ChIP-Seq_LS180_Human1.39799331
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38832211
69RUNX2_22187159_ChIP-Seq_PCA_Human1.38223974
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.37564150
71* REST_21632747_ChIP-Seq_MESCs_Mouse1.36678253
72AHR_22903824_ChIP-Seq_MCF-7_Human1.34876342
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33417412
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32937265
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.32734927
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31061813
77TP53_16413492_ChIP-PET_HCT116_Human1.30749420
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30441663
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30441663
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29946735
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28378878
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28049613
83* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27917979
84* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26998500
85* NANOG_19829295_ChIP-Seq_ESCs_Human1.26670023
86* SOX2_19829295_ChIP-Seq_ESCs_Human1.26670023
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26636933
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25794036
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25116295
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23839672
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23761553
92CDX2_22108803_ChIP-Seq_LS180_Human1.22737986
93P53_22387025_ChIP-Seq_ESCs_Mouse1.22661721
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22476633
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.22089806
96* FLI1_21867929_ChIP-Seq_TH2_Mouse1.21684840
97* AR_19668381_ChIP-Seq_PC3_Human1.20683126
98* SMAD4_21799915_ChIP-Seq_A2780_Human1.19517041
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19287391
100KDM2B_26808549_Chip-Seq_REH_Human1.18093402
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.17808643
102KDM2B_26808549_Chip-Seq_K562_Human1.17304852
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.17280803
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.16278185
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.15916509
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14758614
107* SMAD3_21741376_ChIP-Seq_HESCs_Human1.14306174
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14005751
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.12308409
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11586783
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11377100
112TP53_22573176_ChIP-Seq_HFKS_Human1.11333529
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10407954
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09333296
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.09323099
116TP53_18474530_ChIP-ChIP_U2OS_Human1.09123678
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.08946588
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08868626
119CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08814479
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08514420
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.08446587
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08060320
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08057181
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07721903
125RARB_27405468_Chip-Seq_BRAIN_Mouse1.07690855
126* SMAD4_21741376_ChIP-Seq_HESCs_Human1.06910848
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06795058
128P300_18555785_Chip-Seq_ESCs_Mouse1.06783155
129CJUN_26792858_Chip-Seq_BT549_Human1.06586482
130* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05942390
131BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05873693
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05744096
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05742427
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05723664
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04972659
136YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04855896
137ELK1_19687146_ChIP-ChIP_HELA_Human1.04419761
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04240783
139FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04237943
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03934668
141IRF1_19129219_ChIP-ChIP_H3396_Human1.03846695
142CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03785661
143TRIM28_21343339_ChIP-Seq_HEK293_Human1.03767952
144ESR2_21235772_ChIP-Seq_MCF-7_Human1.03740608
145RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03732164
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02869184
147ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02298740
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02151199
149ZNF274_21170338_ChIP-Seq_K562_Hela1.01699258
150RXR_22108803_ChIP-Seq_LS180_Human1.01186434
151NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01076887
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01076887
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00885090
154REST_18959480_ChIP-ChIP_MESCs_Mouse1.00667335
155SOX2_18555785_Chip-Seq_ESCs_Mouse1.00185085
156RNF2_27304074_Chip-Seq_NSC_Mouse0.99680681
157ESR1_21235772_ChIP-Seq_MCF-7_Human0.99390722
158TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97952125
159* P300_19829295_ChIP-Seq_ESCs_Human0.97564745
160* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97229876
161* STAT3_23295773_ChIP-Seq_U87_Human0.96920288
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95310759
163AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94870551
164CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94385816
165ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93966301
166TAF15_26573619_Chip-Seq_HEK293_Human0.93599674
167STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93055215
168TP63_17297297_ChIP-ChIP_HaCaT_Human0.92959028
169OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92813736
170P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92275130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ3.97142387
2MP0003195_calcinosis3.36237655
3MP0004859_abnormal_synaptic_plasticity3.12558869
4MP0008438_abnormal_cutaneous_collagen2.95686814
5MP0002138_abnormal_hepatobiliary_system2.95330678
6MP0003122_maternal_imprinting2.80921519
7MP0008877_abnormal_DNA_methylation2.77148735
8MP0005503_abnormal_tendon_morphology2.76773296
9MP0003880_abnormal_central_pattern2.69260276
10MP0002928_abnormal_bile_duct2.55499655
11MP0005623_abnormal_meninges_morphology2.54620294
12MP0003136_yellow_coat_color2.43128315
13MP0000534_abnormal_ureter_morphology2.37835033
14MP0003045_fibrosis2.35525200
15MP0005551_abnormal_eye_electrophysiolog2.32768383
16MP0004272_abnormal_basement_membrane2.22555200
17MP0006072_abnormal_retinal_apoptosis2.22320068
18MP0009053_abnormal_anal_canal2.20309180
19MP0000566_synostosis2.17904967
20MP0003635_abnormal_synaptic_transmissio2.09577395
21MP0003942_abnormal_urinary_system2.09442831
22MP0004858_abnormal_nervous_system2.05310101
23MP0005253_abnormal_eye_physiology2.02729814
24MP0000372_irregular_coat_pigmentation1.98822376
25MP0005646_abnormal_pituitary_gland1.85179081
26MP0008057_abnormal_DNA_replication1.84905023
27MP0002254_reproductive_system_inflammat1.83663075
28MP0003787_abnormal_imprinting1.82872826
29MP0000778_abnormal_nervous_system1.82514935
30MP0006054_spinal_hemorrhage1.80559775
31MP0002938_white_spotting1.80392078
32MP0004145_abnormal_muscle_electrophysio1.74850593
33MP0008004_abnormal_stomach_pH1.73106567
34MP0003705_abnormal_hypodermis_morpholog1.67547209
35MP0003252_abnormal_bile_duct1.66796020
36MP0002064_seizures1.66154728
37MP0001486_abnormal_startle_reflex1.65159663
38MP0005084_abnormal_gallbladder_morpholo1.61648009
39MP0003300_gastrointestinal_ulcer1.58861587
40MP0000462_abnormal_digestive_system1.57907595
41MP0002653_abnormal_ependyma_morphology1.57614064
42MP0009046_muscle_twitch1.56484871
43MP0002184_abnormal_innervation1.53821629
44MP0000631_abnormal_neuroendocrine_gland1.51816447
45MP0004133_heterotaxia1.50459791
46MP0003115_abnormal_respiratory_system1.49738709
47MP0000427_abnormal_hair_cycle1.49422998
48MP0003937_abnormal_limbs/digits/tail_de1.47458444
49MP0001485_abnormal_pinna_reflex1.46709794
50MP0001968_abnormal_touch/_nociception1.45504884
51MP0009697_abnormal_copulation1.45404529
52MP0003385_abnormal_body_wall1.44541011
53MP0001958_emphysema1.43920433
54MP0006276_abnormal_autonomic_nervous1.42518042
55MP0008872_abnormal_physiological_respon1.42499582
56MP0002837_dystrophic_cardiac_calcinosis1.42156537
57MP0002063_abnormal_learning/memory/cond1.41900879
58MP0009745_abnormal_behavioral_response1.41549369
59MP0002736_abnormal_nociception_after1.41366069
60MP0002751_abnormal_autonomic_nervous1.41172361
61MP0005174_abnormal_tail_pigmentation1.40840955
62MP0003718_maternal_effect1.39427715
63MP0001984_abnormal_olfaction1.38779275
64MP0004270_analgesia1.37912445
65MP0002282_abnormal_trachea_morphology1.36648963
66MP0009780_abnormal_chondrocyte_physiolo1.34055763
67MP0005275_abnormal_skin_tensile1.34007946
68MP0003646_muscle_fatigue1.33526642
69MP0002876_abnormal_thyroid_physiology1.32879793
70MP0003567_abnormal_fetal_cardiomyocyte1.29819033
71MP0002557_abnormal_social/conspecific_i1.27416183
72MP0002272_abnormal_nervous_system1.27374975
73MP0000955_abnormal_spinal_cord1.26511120
74MP0000579_abnormal_nail_morphology1.25604092
75MP0004134_abnormal_chest_morphology1.25114223
76MP0002572_abnormal_emotion/affect_behav1.24409289
77MP0003690_abnormal_glial_cell1.20471027
78MP0002067_abnormal_sensory_capabilities1.17963505
79MP0002108_abnormal_muscle_morphology1.17796560
80MP0004885_abnormal_endolymph1.17072400
81MP0001440_abnormal_grooming_behavior1.16237292
82MP0009384_cardiac_valve_regurgitation1.13227701
83MP0003950_abnormal_plasma_membrane1.13108956
84MP0002932_abnormal_joint_morphology1.12801050
85MP0002734_abnormal_mechanical_nocicepti1.11746070
86MP0001664_abnormal_digestion1.11378098
87MP0003634_abnormal_glial_cell1.11186743
88MP0003938_abnormal_ear_development1.10600405
89MP0008058_abnormal_DNA_repair1.09866458
90MP0004043_abnormal_pH_regulation1.09391790
91MP0002735_abnormal_chemical_nociception1.09302475
92MP0009250_abnormal_appendicular_skeleto1.07934871
93MP0004742_abnormal_vestibular_system1.06550231
94MP0000516_abnormal_urinary_system1.06345095
95MP0005367_renal/urinary_system_phenotyp1.06345095
96MP0002168_other_aberrant_phenotype1.05285803
97MP0003755_abnormal_palate_morphology1.05108302
98MP0010386_abnormal_urinary_bladder1.04362400
99MP0005220_abnormal_exocrine_pancreas1.03038658
100MP0001529_abnormal_vocalization1.02981497
101MP0005386_behavior/neurological_phenoty1.02354071
102MP0004924_abnormal_behavior1.02354071
103MP0004233_abnormal_muscle_weight1.02222379
104MP0002882_abnormal_neuron_morphology1.01023087
105MP0003121_genomic_imprinting1.00373758
106MP0002234_abnormal_pharynx_morphology0.99484200
107MP0004215_abnormal_myocardial_fiber0.97986988
108MP0000569_abnormal_digit_pigmentation0.96122832
109MP0000920_abnormal_myelination0.95541724
110MP0002090_abnormal_vision0.95362562
111MP0004147_increased_porphyrin_level0.95221757
112MP0005187_abnormal_penis_morphology0.95164882
113MP0002152_abnormal_brain_morphology0.94913527
114MP0005195_abnormal_posterior_eye0.94759467
115MP0002116_abnormal_craniofacial_bone0.94428768
116MP0005508_abnormal_skeleton_morphology0.94066700
117MP0001501_abnormal_sleep_pattern0.94018151
118MP0005171_absent_coat_pigmentation0.93035061
119MP0001986_abnormal_taste_sensitivity0.92750405
120MP0002752_abnormal_somatic_nervous0.92641927
121MP0005423_abnormal_somatic_nervous0.92392078
122MP0000049_abnormal_middle_ear0.92362593
123MP0000647_abnormal_sebaceous_gland0.91451395
124MP0005395_other_phenotype0.91300308
125MP0004142_abnormal_muscle_tone0.90171681
126MP0003890_abnormal_embryonic-extraembry0.89944011
127MP0001299_abnormal_eye_distance/0.89367221
128MP0003279_aneurysm0.88981397
129MP0001970_abnormal_pain_threshold0.88950907
130MP0005391_vision/eye_phenotype0.88950725
131MP0000383_abnormal_hair_follicle0.88115887
132MP0002733_abnormal_thermal_nociception0.86737996
133MP0002233_abnormal_nose_morphology0.86172340
134MP0008569_lethality_at_weaning0.85864287
135MP0002095_abnormal_skin_pigmentation0.85476158
136MP0003119_abnormal_digestive_system0.84702825
137MP0000751_myopathy0.83609139
138MP0000537_abnormal_urethra_morphology0.83286081
139MP0002229_neurodegeneration0.82849813
140MP0000015_abnormal_ear_pigmentation0.82430199
141MP0001188_hyperpigmentation0.81654201
142MP0003861_abnormal_nervous_system0.81327412
143MP0002896_abnormal_bone_mineralization0.80056551
144MP0002066_abnormal_motor_capabilities/c0.80050963
145MP0008961_abnormal_basal_metabolism0.79546126
146MP0001324_abnormal_eye_pigmentation0.79530579
147MP0002249_abnormal_larynx_morphology0.79031655
148MP0002697_abnormal_eye_size0.78972547
149MP0003698_abnormal_male_reproductive0.78842142
150MP0000163_abnormal_cartilage_morphology0.78052804
151MP0002163_abnormal_gland_morphology0.77981652
152MP0005379_endocrine/exocrine_gland_phen0.77917461
153MP0005075_abnormal_melanosome_morpholog0.77841778
154MP0004811_abnormal_neuron_physiology0.77164714
155MP0000767_abnormal_smooth_muscle0.77102470
156MP0002638_abnormal_pupillary_reflex0.76920310
157MP0005083_abnormal_biliary_tract0.74640927
158MP0000428_abnormal_craniofacial_morphol0.72440547
159MP0002102_abnormal_ear_morphology0.72043062
160MP0003935_abnormal_craniofacial_develop0.71631222
161MP0005645_abnormal_hypothalamus_physiol0.69617481

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.10151142
2Glomerulonephritis (HP:0000099)3.90175223
3Urethral obstruction (HP:0000796)3.69437023
4Protrusio acetabuli (HP:0003179)3.52962024
5True hermaphroditism (HP:0010459)3.51305501
6Pancreatic fibrosis (HP:0100732)3.44980366
7Concave nail (HP:0001598)3.35244084
8Arterial tortuosity (HP:0005116)3.35197235
9Hyperventilation (HP:0002883)3.28458501
10Nephronophthisis (HP:0000090)3.25527941
11Molar tooth sign on MRI (HP:0002419)3.25366580
12Abnormality of midbrain morphology (HP:0002418)3.25366580
13Renal duplication (HP:0000075)3.22483103
14Split foot (HP:0001839)3.19129757
15Cerebral aneurysm (HP:0004944)3.17535191
16Attenuation of retinal blood vessels (HP:0007843)3.13549543
17Abnormality of the renal medulla (HP:0100957)3.09752644
18Gaze-evoked nystagmus (HP:0000640)3.09165040
19Shallow orbits (HP:0000586)3.06859191
20Aplasia/Hypoplasia of the tibia (HP:0005772)3.03565569
21Congenital stationary night blindness (HP:0007642)3.02737475
22Vascular tortuosity (HP:0004948)3.01999137
23Abnormality of the renal cortex (HP:0011035)3.01639125
24Arnold-Chiari malformation (HP:0002308)2.91664911
25Facial shape deformation (HP:0011334)2.89630000
26Potter facies (HP:0002009)2.89630000
27Aortic dissection (HP:0002647)2.79727120
28Medial flaring of the eyebrow (HP:0010747)2.79505935
29Striae distensae (HP:0001065)2.74913913
30Abnormality of macular pigmentation (HP:0008002)2.71225363
31Ankle contracture (HP:0006466)2.71072458
32Central scotoma (HP:0000603)2.69437958
33Aortic aneurysm (HP:0004942)2.68972107
34Broad metatarsal (HP:0001783)2.68388368
35Increased corneal curvature (HP:0100692)2.67464381
36Keratoconus (HP:0000563)2.67464381
37Narrow nasal bridge (HP:0000446)2.67274554
38Severe visual impairment (HP:0001141)2.62873884
39Scotoma (HP:0000575)2.61699700
40Type II lissencephaly (HP:0007260)2.61125440
41Bladder diverticulum (HP:0000015)2.56925817
42Premature rupture of membranes (HP:0001788)2.56326678
43Elfin facies (HP:0004428)2.51960304
44Focal seizures (HP:0007359)2.48517723
45Cystic liver disease (HP:0006706)2.48310364
46Chronic hepatic failure (HP:0100626)2.47781256
47Megalencephaly (HP:0001355)2.47383733
48Soft skin (HP:0000977)2.46741099
49Abolished electroretinogram (ERG) (HP:0000550)2.46395955
50Optic nerve hypoplasia (HP:0000609)2.36910394
51Progressive inability to walk (HP:0002505)2.36556491
52Tubular atrophy (HP:0000092)2.35736911
53Focal motor seizures (HP:0011153)2.33225488
54Abnormal pancreas size (HP:0012094)2.32404116
55Preaxial foot polydactyly (HP:0001841)2.31845668
56Oligodactyly (hands) (HP:0001180)2.30987568
57Myokymia (HP:0002411)2.30987478
58Neonatal short-limb short stature (HP:0008921)2.30712871
59Congenital primary aphakia (HP:0007707)2.29909644
60Bony spicule pigmentary retinopathy (HP:0007737)2.29864360
61Absent speech (HP:0001344)2.29422825
62Gait imbalance (HP:0002141)2.29048441
63Pterygium (HP:0001059)2.28580213
64Genital tract atresia (HP:0001827)2.27775360
65Coronal craniosynostosis (HP:0004440)2.26957759
66Mitral valve prolapse (HP:0001634)2.26580813
67Cerebellar dysplasia (HP:0007033)2.26529590
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26337876
69Partial duplication of thumb phalanx (HP:0009944)2.25759986
70Hepatoblastoma (HP:0002884)2.25428790
71Follicular hyperkeratosis (HP:0007502)2.25147420
72Abnormal rod and cone electroretinograms (HP:0008323)2.22995861
73Inability to walk (HP:0002540)2.22028025
74Tubulointerstitial fibrosis (HP:0005576)2.21160878
75Volvulus (HP:0002580)2.20529653
76Atrophic scars (HP:0001075)2.19992103
77Vaginal atresia (HP:0000148)2.18479747
78Short tibia (HP:0005736)2.17592303
79Lower limb asymmetry (HP:0100559)2.16267825
80Abnormality of the radial head (HP:0003995)2.15562461
81Flat cornea (HP:0007720)2.15069950
82Febrile seizures (HP:0002373)2.14155362
83Fragile skin (HP:0001030)2.14089130
84Insomnia (HP:0100785)2.13966078
85Congenital sensorineural hearing impairment (HP:0008527)2.12449090
86Aplasia of the musculature (HP:0100854)2.11923101
87Disproportionate tall stature (HP:0001519)2.11871600
88Abnormality of the labia minora (HP:0012880)2.10277784
89Small hand (HP:0200055)2.10138808
90Nephrogenic diabetes insipidus (HP:0009806)2.09992476
91Decreased central vision (HP:0007663)2.09698639
92Partial duplication of the phalanx of hand (HP:0009999)2.08140126
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.07877878
94Protruding tongue (HP:0010808)2.06938453
95Hyperglycinemia (HP:0002154)2.05248628
96Supranuclear gaze palsy (HP:0000605)2.04945832
97Lissencephaly (HP:0001339)2.04885661
98Slender build (HP:0001533)2.04599385
99Renal cortical cysts (HP:0000803)2.04311747
100Renovascular hypertension (HP:0100817)2.04263145
101Action tremor (HP:0002345)2.03126156
102Broad-based gait (HP:0002136)2.02151991
103Anophthalmia (HP:0000528)2.02113213
104Pendular nystagmus (HP:0012043)2.01831358
105Sclerocornea (HP:0000647)2.01520557
106Aplasia/Hypoplasia of the uvula (HP:0010293)2.00562518
107Enlarged kidneys (HP:0000105)2.00270353
108Germ cell neoplasia (HP:0100728)1.99930365
109Hemiparesis (HP:0001269)1.99702029
110Abnormality of the ischium (HP:0003174)1.98814415
111Overgrowth (HP:0001548)1.98807001
112Hypothermia (HP:0002045)1.98733681
113Abnormality of the antihelix (HP:0009738)1.97930714
114Abnormality of the ileum (HP:0001549)1.96627933
115Hyperacusis (HP:0010780)1.95961288
116Postaxial foot polydactyly (HP:0001830)1.95863587
117Hypoplastic ischia (HP:0003175)1.95661475
118Hypoventilation (HP:0002791)1.95170610
119Ventricular fibrillation (HP:0001663)1.93826417
120Ridged nail (HP:0001807)1.93711492
121Epileptic encephalopathy (HP:0200134)1.93525016
122Dandy-Walker malformation (HP:0001305)1.93485242
123Anal stenosis (HP:0002025)1.92815896
124Prolonged QT interval (HP:0001657)1.91803493
125Bifid tongue (HP:0010297)1.90730408
126Colon cancer (HP:0003003)1.90717652
127Abnormality of the fovea (HP:0000493)1.90685713
128Short foot (HP:0001773)1.89008505
129Renal hypoplasia (HP:0000089)1.88433938
130Tubulointerstitial abnormality (HP:0001969)1.88087727
131Ankle clonus (HP:0011448)1.87981056
132Astigmatism (HP:0000483)1.87478152
133Genetic anticipation (HP:0003743)1.87013644
134Aplasia of the phalanges of the hand (HP:0009802)1.86330241
135Aplasia involving bones of the extremities (HP:0009825)1.86330241
136Aplasia involving bones of the upper limbs (HP:0009823)1.86330241
137Abnormal drinking behavior (HP:0030082)1.85773819
138Polydipsia (HP:0001959)1.85773819
139Nephritis (HP:0000123)1.85697275
140Vitreoretinal degeneration (HP:0000655)1.85204135
141Male pseudohermaphroditism (HP:0000037)1.84564301
142Postaxial hand polydactyly (HP:0001162)1.84186747
143Congenital hepatic fibrosis (HP:0002612)1.84035042
144Bowel incontinence (HP:0002607)1.83803819
145Hemiplegia (HP:0002301)1.82622221
146Joint laxity (HP:0001388)1.82389436
147Hyperextensible skin (HP:0000974)1.81912619
148Meckel diverticulum (HP:0002245)1.80813407
149Anencephaly (HP:0002323)1.80501153
150Obstructive sleep apnea (HP:0002870)1.80116853
151Overfolded helix (HP:0000396)1.79920708
152Narrow palate (HP:0000189)1.79679723
153Overriding aorta (HP:0002623)1.79610569
154Abnormality of the right ventricle (HP:0001707)1.78313092
155Abnormality of the astrocytes (HP:0100707)1.78006126
156Astrocytoma (HP:0009592)1.78006126
157Preaxial hand polydactyly (HP:0001177)1.77995154
158Intestinal atresia (HP:0011100)1.77313797
159Abnormally folded helix (HP:0008544)1.76261487
160Metaphyseal dysplasia (HP:0100255)1.75430655
161Chorioretinal atrophy (HP:0000533)1.74766570
162Thyroid-stimulating hormone excess (HP:0002925)1.74197404
163Lymphangioma (HP:0100764)1.74146992
164Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73903913
165Large for gestational age (HP:0001520)1.73622025
166Broad thumb (HP:0011304)1.73271441
167Patellar dislocation (HP:0002999)1.72797878
168Sloping forehead (HP:0000340)1.72733883
169Polyuria (HP:0000103)1.72263395
170Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.71394887
171Fair hair (HP:0002286)1.70944757
172Camptodactyly of toe (HP:0001836)1.70861291
173Neonatal respiratory distress (HP:0002643)1.70603270
174Abnormality of dentin (HP:0010299)1.67691660
175Cupped ear (HP:0000378)1.67655225
176Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.67524813
177Broad ribs (HP:0000885)1.67403839
178Abnormality of the parathyroid morphology (HP:0011766)1.67293015
179Gastrointestinal atresia (HP:0002589)1.66818172
180Abnormality of the epiphyses of the hand (HP:0005924)1.66792477
181Narrow forehead (HP:0000341)1.66744888
182Spondylolisthesis (HP:0003302)1.66737052
183Progressive cerebellar ataxia (HP:0002073)1.66224956
184Poor coordination (HP:0002370)1.65647610
185Exostoses (HP:0100777)1.65040870
186Wide anterior fontanel (HP:0000260)1.63714099
187Aqueductal stenosis (HP:0002410)1.63261411
188Blue sclerae (HP:0000592)1.62843316
189Mutism (HP:0002300)1.62778098
190Midline defect of the nose (HP:0004122)1.61987908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.78639794
2LMTK23.31141700
3CAMK1G3.15102472
4EEF2K2.91129346
5MAP4K22.65596433
6BMPR1B2.51403170
7WNK32.50791240
8PRKD32.47251273
9TGFBR22.42803353
10EPHA42.41249358
11STK38L2.40504022
12NUAK12.32778694
13MAPK152.29064307
14CAMK1D2.27054208
15MAPK132.25037215
16MAP3K92.19022665
17ADRBK22.10288456
18EPHB22.06916075
19NTRK21.99248291
20PNCK1.95963300
21ICK1.94888860
22SIK11.85210613
23TRIM281.76484936
24PHKG11.74428008
25PHKG21.74428008
26ACVR1B1.74391792
27MKNK21.68185409
28SIK21.67528990
29NTRK31.65296671
30TRIB31.62278198
31DDR21.61443410
32PINK11.58341703
33MARK11.57135772
34SIK31.55991820
35DAPK21.51138060
36ZAK1.50987924
37GRK11.48463161
38UHMK11.48080445
39MAPKAPK31.45189897
40TAF11.42472864
41MINK11.39848344
42RIPK41.36374478
43MAP3K41.34307167
44TYRO31.30498604
45BRSK21.30261928
46PLK21.29551189
47STK31.28873593
48ERBB21.28377251
49PAK61.27078226
50PDGFRA1.26762104
51RIPK11.25897579
52ERBB31.25137961
53CSNK1G11.22569281
54KSR11.21158050
55TNIK1.21115169
56LATS11.19607297
57CAMK41.17420333
58NEK61.14942990
59MAPKAPK51.14872397
60MKNK11.12800096
61CAMKK11.11456728
62CSNK1G21.11284823
63PAK41.09185074
64AKT31.07664067
65EIF2AK31.07533452
66BCR1.07227925
67MST41.06511150
68DYRK21.05865143
69PLK31.05516459
70WEE11.00922703
71IRAK10.99790913
72MAPK120.97311351
73OXSR10.96654652
74DMPK0.95545163
75CSNK1G30.94618475
76NTRK10.88605963
77CAMK10.87959413
78SGK2230.87135808
79SGK4940.87135808
80MARK20.86882173
81FGFR20.85220989
82WNK10.84970576
83CASK0.84701663
84GRK70.84496990
85CDK50.83358849
86PRKCG0.83183557
87STK380.82257890
88TAOK30.81663268
89PAK30.81069245
90PDK20.80511869
91RPS6KA20.79896147
92FER0.79669290
93PRKCH0.79256888
94FGR0.77031036
95NLK0.76391661
96PIK3CG0.75613344
97PTK60.75373715
98PAK20.75034649
99ADRBK10.73542165
100CDK190.72594975
101PTK2B0.71982478
102MAP3K120.71951045
103SRPK10.70602691
104PKN10.69991178
105STK390.69615794
106TIE10.69074527
107CDC42BPA0.68729543
108PTK20.67901317
109MAP2K70.67651561
110CAMK2A0.67459344
111CSNK1A1L0.65835260
112ROCK20.65364607
113LATS20.62525785
114MAP3K70.61294057
115KSR20.60135579
116SRC0.58069007
117VRK10.57278198
118MAP2K40.57025850
119PRKD20.56716237
120TRPM70.56176199
121DYRK30.55562208
122SGK20.53978951
123FYN0.53391926
124SGK30.51565138
125PLK40.51524940
126PRKCE0.50916364
127CSNK1D0.50383521
128EPHB10.49457241
129IRAK20.49317664
130FGFR10.49228548
131WNK40.49134033
132PRKAA20.49018337
133FES0.48679798
134CAMKK20.47941990
135CDK180.46068684
136ATM0.45029557
137CDK150.44721137
138DAPK10.43234103
139DYRK1A0.42924681
140CDK11A0.42764556
141MTOR0.42559321
142PLK10.42431603
143CSNK1A10.42366762
144PRKCZ0.42269607
145BCKDK0.42000977
146INSRR0.41547709
147EIF2AK10.41241629
148PRKD10.40398997
149CDK30.39792273
150EPHA30.39558381
151TSSK60.39507640
152CAMK2D0.37045728
153FLT30.35941672
154ERBB40.35840312
155RPS6KA40.34683569
156EIF2AK20.34498239
157ATR0.34369831
158PRKG10.34038217
159MUSK0.32565200
160CDC70.30996941
161TGFBR10.30420969
162TEC0.29246080
163NEK10.28894643
164PRKACA0.28420536
165CAMK2B0.28410579
166PRKACB0.27041667
167PRKAA10.26947060

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.19308533
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80637017
3Phototransduction_Homo sapiens_hsa047442.68672340
4Pancreatic secretion_Homo sapiens_hsa049722.49592621
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32723644
6Protein digestion and absorption_Homo sapiens_hsa049742.31450676
7Propanoate metabolism_Homo sapiens_hsa006402.30607698
8Axon guidance_Homo sapiens_hsa043602.12609645
9Homologous recombination_Homo sapiens_hsa034402.09393606
10Nicotine addiction_Homo sapiens_hsa050332.07682724
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04696304
12Glutamatergic synapse_Homo sapiens_hsa047242.04690539
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97491520
14Non-homologous end-joining_Homo sapiens_hsa034501.83246452
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82297754
16Hedgehog signaling pathway_Homo sapiens_hsa043401.80689221
17Salivary secretion_Homo sapiens_hsa049701.78082892
18Basal cell carcinoma_Homo sapiens_hsa052171.77674227
19Basal transcription factors_Homo sapiens_hsa030221.76952929
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76537177
21Selenocompound metabolism_Homo sapiens_hsa004501.75577323
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74571973
23Linoleic acid metabolism_Homo sapiens_hsa005911.74478200
24Fanconi anemia pathway_Homo sapiens_hsa034601.73282145
25Circadian entrainment_Homo sapiens_hsa047131.70183802
26Gastric acid secretion_Homo sapiens_hsa049711.69036514
27GABAergic synapse_Homo sapiens_hsa047271.67938432
28Tryptophan metabolism_Homo sapiens_hsa003801.65228029
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62401385
30Protein export_Homo sapiens_hsa030601.59467316
31Morphine addiction_Homo sapiens_hsa050321.55057795
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.54690615
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54052188
34ECM-receptor interaction_Homo sapiens_hsa045121.52478545
35Synaptic vesicle cycle_Homo sapiens_hsa047211.51168136
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51138601
37Melanogenesis_Homo sapiens_hsa049161.49456152
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49418570
39Renin secretion_Homo sapiens_hsa049241.47859277
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46034272
41Caffeine metabolism_Homo sapiens_hsa002321.43011981
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38090610
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36210534
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.35264723
45Olfactory transduction_Homo sapiens_hsa047401.31013916
46Cholinergic synapse_Homo sapiens_hsa047251.30567235
47Long-term potentiation_Homo sapiens_hsa047201.29016653
48Insulin secretion_Homo sapiens_hsa049111.28630813
49Long-term depression_Homo sapiens_hsa047301.28187158
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26763272
51Amphetamine addiction_Homo sapiens_hsa050311.23911402
52Gap junction_Homo sapiens_hsa045401.23888944
53ABC transporters_Homo sapiens_hsa020101.23552669
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23521365
55GnRH signaling pathway_Homo sapiens_hsa049121.23363093
56cAMP signaling pathway_Homo sapiens_hsa040241.22961568
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22154648
58Hippo signaling pathway_Homo sapiens_hsa043901.19837803
59Notch signaling pathway_Homo sapiens_hsa043301.19475401
60Retinol metabolism_Homo sapiens_hsa008301.18916557
61Estrogen signaling pathway_Homo sapiens_hsa049151.15790907
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14381603
63Dopaminergic synapse_Homo sapiens_hsa047281.13070641
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.12155235
65Taste transduction_Homo sapiens_hsa047421.12135618
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10929145
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10802880
68Cocaine addiction_Homo sapiens_hsa050301.10224236
69beta-Alanine metabolism_Homo sapiens_hsa004101.09999806
70Calcium signaling pathway_Homo sapiens_hsa040201.07758405
71Nitrogen metabolism_Homo sapiens_hsa009101.06052474
72Wnt signaling pathway_Homo sapiens_hsa043101.05551007
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05490773
74Chemical carcinogenesis_Homo sapiens_hsa052041.02282446
75Steroid biosynthesis_Homo sapiens_hsa001001.02069122
76Oxytocin signaling pathway_Homo sapiens_hsa049211.01148643
77Phospholipase D signaling pathway_Homo sapiens_hsa040721.01124361
78Circadian rhythm_Homo sapiens_hsa047100.99710859
79Regulation of autophagy_Homo sapiens_hsa041400.98701480
80Focal adhesion_Homo sapiens_hsa045100.98282853
81Rap1 signaling pathway_Homo sapiens_hsa040150.98186267
82Serotonergic synapse_Homo sapiens_hsa047260.93834313
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93280827
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92455095
85Dilated cardiomyopathy_Homo sapiens_hsa054140.91900389
86Thyroid hormone synthesis_Homo sapiens_hsa049180.91885784
87RNA degradation_Homo sapiens_hsa030180.90407304
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89824553
89Fatty acid elongation_Homo sapiens_hsa000620.89803073
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89505391
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89166529
92Choline metabolism in cancer_Homo sapiens_hsa052310.88816399
93Glioma_Homo sapiens_hsa052140.88448446
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88439590
95Renal cell carcinoma_Homo sapiens_hsa052110.87465333
96RNA polymerase_Homo sapiens_hsa030200.87030199
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.86552596
98Ether lipid metabolism_Homo sapiens_hsa005650.85945961
99Sphingolipid metabolism_Homo sapiens_hsa006000.84757315
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83289234
101Peroxisome_Homo sapiens_hsa041460.83111848
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82809636
103Adherens junction_Homo sapiens_hsa045200.82726864
104ErbB signaling pathway_Homo sapiens_hsa040120.82539964
105Dorso-ventral axis formation_Homo sapiens_hsa043200.81715716
106Sulfur metabolism_Homo sapiens_hsa009200.80768116
107Tight junction_Homo sapiens_hsa045300.79878300
108Colorectal cancer_Homo sapiens_hsa052100.79821213
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77373012
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76723154
111Lysine degradation_Homo sapiens_hsa003100.76473129
112Type II diabetes mellitus_Homo sapiens_hsa049300.76126631
113Ras signaling pathway_Homo sapiens_hsa040140.75284846
114Proteoglycans in cancer_Homo sapiens_hsa052050.73325228
115Amoebiasis_Homo sapiens_hsa051460.72928825
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.72385140
117Pancreatic cancer_Homo sapiens_hsa052120.71990989
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71949571
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.71492616
120One carbon pool by folate_Homo sapiens_hsa006700.70840774
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70495709
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70342529
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69810327
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69392968
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68905760
126Fat digestion and absorption_Homo sapiens_hsa049750.68547266
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68421821
128Platelet activation_Homo sapiens_hsa046110.68155538
129Prion diseases_Homo sapiens_hsa050200.67813756
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67812333
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67688885
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65729837
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65709404
134Fatty acid metabolism_Homo sapiens_hsa012120.64393662
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62994871
136Endometrial cancer_Homo sapiens_hsa052130.62364993
137TGF-beta signaling pathway_Homo sapiens_hsa043500.62022546
138Purine metabolism_Homo sapiens_hsa002300.61215958
139Pathways in cancer_Homo sapiens_hsa052000.60628965
140Fatty acid degradation_Homo sapiens_hsa000710.59793596
141Glutathione metabolism_Homo sapiens_hsa004800.59007643
142Ovarian steroidogenesis_Homo sapiens_hsa049130.58927968
143Arachidonic acid metabolism_Homo sapiens_hsa005900.58186432
144Melanoma_Homo sapiens_hsa052180.58132271
145Metabolic pathways_Homo sapiens_hsa011000.58046139
146Vibrio cholerae infection_Homo sapiens_hsa051100.57559151
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57177470
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.56945029
149Endocytosis_Homo sapiens_hsa041440.50592793
150Glycerolipid metabolism_Homo sapiens_hsa005610.50442544
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50252654
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50134552
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49865138
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48468089
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48394619
156Fatty acid biosynthesis_Homo sapiens_hsa000610.47331052
157Histidine metabolism_Homo sapiens_hsa003400.45505795
158Proteasome_Homo sapiens_hsa030500.45326792
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41516542
160RNA transport_Homo sapiens_hsa030130.40597327
161Arginine and proline metabolism_Homo sapiens_hsa003300.37355102

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