ADAMTS17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.14381074
2drug catabolic process (GO:0042737)6.78930223
3fusion of sperm to egg plasma membrane (GO:0007342)6.77169056
4acrosome reaction (GO:0007340)6.74809087
5glyoxylate metabolic process (GO:0046487)6.68965554
6exogenous drug catabolic process (GO:0042738)6.02418841
7multicellular organism reproduction (GO:0032504)5.58477260
8establishment of protein localization to Golgi (GO:0072600)5.48247461
9protein targeting to Golgi (GO:0000042)5.47404217
10retrograde transport, vesicle recycling within Golgi (GO:0000301)5.20000625
11chromosome condensation (GO:0030261)5.14088978
12serine family amino acid catabolic process (GO:0009071)5.09960831
13oxidative demethylation (GO:0070989)5.06802491
14phenylpropanoid metabolic process (GO:0009698)5.03983633
15protein polyglutamylation (GO:0018095)4.98638508
16DNA packaging (GO:0006323)4.94373059
17cellular ketone body metabolic process (GO:0046950)4.93474776
18plasma membrane fusion (GO:0045026)4.90968964
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.80623699
20L-phenylalanine catabolic process (GO:0006559)4.80623699
21sperm-egg recognition (GO:0035036)4.74715706
22spermatid development (GO:0007286)4.64923606
23microtubule depolymerization (GO:0007019)4.60322280
24reproduction (GO:0000003)4.57709568
25binding of sperm to zona pellucida (GO:0007339)4.51363992
26sperm capacitation (GO:0048240)4.46266618
27urea metabolic process (GO:0019627)4.45951216
28axonemal dynein complex assembly (GO:0070286)4.43476871
29regulation of non-canonical Wnt signaling pathway (GO:2000050)4.37141167
30ketone body metabolic process (GO:1902224)4.35527201
31cilium or flagellum-dependent cell motility (GO:0001539)4.33232725
32regulation of fibrinolysis (GO:0051917)4.32170372
33microtubule polymerization or depolymerization (GO:0031109)4.29656928
34coenzyme catabolic process (GO:0009109)4.28103153
35negative regulation of fibrinolysis (GO:0051918)4.27272312
36motile cilium assembly (GO:0044458)4.24224905
37epoxygenase P450 pathway (GO:0019373)4.23903715
38L-phenylalanine metabolic process (GO:0006558)4.20122893
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.20122893
40glycine metabolic process (GO:0006544)4.16646630
41single strand break repair (GO:0000012)4.09556078
42regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.05740222
43omega-hydroxylase P450 pathway (GO:0097267)4.05453479
44protein localization to Golgi apparatus (GO:0034067)4.04218443
45regulation of triglyceride catabolic process (GO:0010896)4.03880939
46single fertilization (GO:0007338)3.96826728
47bile acid biosynthetic process (GO:0006699)3.94113686
48arginine metabolic process (GO:0006525)3.93806397
49spermatogenesis (GO:0007283)3.93155120
50male gamete generation (GO:0048232)3.92644720
51drug metabolic process (GO:0017144)3.91085506
52mesenchymal cell differentiation involved in kidney development (GO:0072161)3.90193845
53mesenchymal cell differentiation involved in renal system development (GO:2001012)3.90193845
54urea cycle (GO:0000050)3.87154090
55nitrogen cycle metabolic process (GO:0071941)3.84904363
56cellular glucuronidation (GO:0052695)3.84826348
57cell-cell recognition (GO:0009988)3.84508873
58hormone catabolic process (GO:0042447)3.81420186
59centriole replication (GO:0007099)3.81214735
60arginine catabolic process (GO:0006527)3.77654457
61central nervous system projection neuron axonogenesis (GO:0021952)3.75013665
62calcium ion-dependent exocytosis (GO:0017156)3.71047129
63alkaloid metabolic process (GO:0009820)3.70651603
64bile acid and bile salt transport (GO:0015721)3.67231536
65rRNA methylation (GO:0031167)3.66485033
66peptidyl-glutamic acid modification (GO:0018200)3.66482559
67cilium movement (GO:0003341)3.66387990
68gamete generation (GO:0007276)3.66229395
69phosphatidylethanolamine biosynthetic process (GO:0006646)3.65489304
70presynaptic membrane assembly (GO:0097105)3.63587335
71regulation of acrosome reaction (GO:0060046)3.59597736
72regulation of protein activation cascade (GO:2000257)3.57057307
73centriole assembly (GO:0098534)3.55974938
74fibrinolysis (GO:0042730)3.54562076
75uronic acid metabolic process (GO:0006063)3.54002534
76glucuronate metabolic process (GO:0019585)3.54002534
77spermatid nucleus differentiation (GO:0007289)3.53857578
78aromatic amino acid family catabolic process (GO:0009074)3.51489769
79imidazole-containing compound metabolic process (GO:0052803)3.49641320
80presynaptic membrane organization (GO:0097090)3.49381852
81epithelial cilium movement (GO:0003351)3.49085506
82organic cation transport (GO:0015695)3.47511133
83head development (GO:0060322)3.47249802
84complement activation, alternative pathway (GO:0006957)3.45299939
85bone trabecula formation (GO:0060346)3.44280867
86microtubule severing (GO:0051013)3.41695411
87phosphatidylethanolamine metabolic process (GO:0046337)3.41213089
88negative regulation of stem cell proliferation (GO:2000647)3.39808672
89axon extension involved in axon guidance (GO:0048846)3.38778099
90neuron projection extension involved in neuron projection guidance (GO:1902284)3.38778099
91bile acid metabolic process (GO:0008206)3.38573632
92fertilization (GO:0009566)3.33373428
93cofactor catabolic process (GO:0051187)3.32453852
94negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.31260957
95planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30583442
96serine family amino acid metabolic process (GO:0009069)3.29139422
97lateral sprouting from an epithelium (GO:0060601)3.25070908
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24671172
99positive regulation of synapse assembly (GO:0051965)3.24211264
100peptidyl-glutamic acid carboxylation (GO:0017187)3.23869243
101protein carboxylation (GO:0018214)3.23869243
102metanephric mesenchyme development (GO:0072075)3.23437477
103piRNA metabolic process (GO:0034587)3.21330978
104cell proliferation involved in metanephros development (GO:0072203)3.20577440
105seminiferous tubule development (GO:0072520)3.19492237
106negative regulation of axon extension involved in axon guidance (GO:0048843)3.18798699
107negative regulation of keratinocyte proliferation (GO:0010839)3.16750312
108negative regulation of sterol transport (GO:0032372)3.16611331
109negative regulation of cholesterol transport (GO:0032375)3.16611331
110blood coagulation, intrinsic pathway (GO:0007597)3.13695704
111cranial nerve morphogenesis (GO:0021602)3.12578766
112negative regulation of axon guidance (GO:1902668)3.12558308
113regulation of Rab GTPase activity (GO:0032313)3.08569190
114positive regulation of Rab GTPase activity (GO:0032851)3.08569190
115mesenchyme morphogenesis (GO:0072132)3.07741581
116cerebral cortex radially oriented cell migration (GO:0021799)3.07663813
117regulation of short-term neuronal synaptic plasticity (GO:0048172)3.06183578
118heme transport (GO:0015886)3.06121714
119postsynaptic membrane organization (GO:0001941)3.05308255
120regulation of complement activation (GO:0030449)3.04860576
121triglyceride homeostasis (GO:0070328)3.04482342
122acylglycerol homeostasis (GO:0055090)3.04482342
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03459881
124central nervous system neuron axonogenesis (GO:0021955)3.01296610
125regulation of synapse assembly (GO:0051963)2.96135066
126RNA destabilization (GO:0050779)2.95785101
127axonal fasciculation (GO:0007413)2.95687537
128tyrosine metabolic process (GO:0006570)2.95553588
129genitalia morphogenesis (GO:0035112)2.95117235
130neuron recognition (GO:0008038)2.94615676
131mesenchymal cell differentiation (GO:0048762)2.93116546
132extracellular regulation of signal transduction (GO:1900115)2.88321147
133extracellular negative regulation of signal transduction (GO:1900116)2.88321147
134cell proliferation involved in kidney development (GO:0072111)2.88173505
135kidney mesenchyme development (GO:0072074)2.87920779
136startle response (GO:0001964)2.86108027
137negative chemotaxis (GO:0050919)2.84409120
138facial nerve structural organization (GO:0021612)2.83284808
139innervation (GO:0060384)2.82972953
140mesonephros development (GO:0001823)2.82355659
141cranial nerve structural organization (GO:0021604)2.77370374
142cell differentiation involved in kidney development (GO:0061005)2.74953680
143cell differentiation involved in metanephros development (GO:0072202)2.72757166
144embryonic forelimb morphogenesis (GO:0035115)2.67754369
145sequestering of extracellular ligand from receptor (GO:0035581)2.67682158
146establishment of tissue polarity (GO:0007164)2.66986148
147establishment of planar polarity (GO:0001736)2.66986148
148regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.66425606
149regulation of axon guidance (GO:1902667)2.65595074
150negative regulation of embryonic development (GO:0045992)2.64548262
151Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.63656108
152regulation of axon extension involved in axon guidance (GO:0048841)2.63077544
153convergent extension (GO:0060026)2.62652629
154ionotropic glutamate receptor signaling pathway (GO:0035235)2.61873983
155mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58575587
156urinary tract smooth muscle contraction (GO:0014848)2.58341007
157righting reflex (GO:0060013)2.56987410
158endocardial cushion morphogenesis (GO:0003203)2.56500219
159regulation of somitogenesis (GO:0014807)2.55774584
160protein localization to synapse (GO:0035418)2.55630676
161inner ear receptor stereocilium organization (GO:0060122)2.52811119
162regulation of mesenchymal cell apoptotic process (GO:2001053)2.52635909
163somite development (GO:0061053)2.52310615
164epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.52185928
165neuron cell-cell adhesion (GO:0007158)2.51783573
166chondrocyte development (GO:0002063)2.50755961
167vocalization behavior (GO:0071625)2.50262512
168regulation of establishment of planar polarity (GO:0090175)2.50055998
169auditory behavior (GO:0031223)2.49585971
170positive regulation of meiosis (GO:0045836)2.48881097
171neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.48826869
172ganglion development (GO:0061548)2.48237591
173G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.46252077
174embryonic digestive tract morphogenesis (GO:0048557)2.45279029
175female gonad development (GO:0008585)2.43751957
176regulation of synapse organization (GO:0050807)2.43174649
177specification of organ identity (GO:0010092)2.42984106
178cochlea development (GO:0090102)2.42805931
179glomerulus development (GO:0032835)2.42058113
180forelimb morphogenesis (GO:0035136)2.41911135
181embryonic limb morphogenesis (GO:0030326)2.41790184
182embryonic appendage morphogenesis (GO:0035113)2.41790184
183response to pheromone (GO:0019236)2.40193544
184mechanoreceptor differentiation (GO:0042490)2.40007039
185cochlea morphogenesis (GO:0090103)2.39365238
186proximal/distal pattern formation (GO:0009954)2.39086527
187dentate gyrus development (GO:0021542)2.39028578
188positive regulation of smoothened signaling pathway (GO:0045880)2.38372359
189glutamate receptor signaling pathway (GO:0007215)2.38191213
190regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.38179196
191anatomical structure arrangement (GO:0048532)2.37975074
192limb bud formation (GO:0060174)2.37168533
193synaptic transmission, glutamatergic (GO:0035249)2.37119438
194retinal ganglion cell axon guidance (GO:0031290)2.36486786
195cartilage morphogenesis (GO:0060536)2.35046693
196positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.33006912
197phosphorelay signal transduction system (GO:0000160)2.32966357
198atrial cardiac muscle cell action potential (GO:0086014)2.32940291
199cardiac ventricle formation (GO:0003211)2.32665814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.20983350
2EZH2_22144423_ChIP-Seq_EOC_Human4.91841861
3GBX2_23144817_ChIP-Seq_PC3_Human3.88128850
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.43346377
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.12800172
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97246748
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.88144151
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76056793
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.70550805
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63583009
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58701305
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.57570357
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54057193
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45376125
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45376125
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44959381
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.38288130
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37698377
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34981253
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34719489
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23083642
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21551308
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21377242
24CBP_20019798_ChIP-Seq_JUKART_Human2.21318238
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.21318238
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.20351212
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16712237
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.16369434
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16078475
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08770435
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.06281356
32IGF1R_20145208_ChIP-Seq_DFB_Human1.98267993
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.96324929
34ER_23166858_ChIP-Seq_MCF-7_Human1.95596632
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87412135
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87139083
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85481107
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81803202
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81188761
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80361785
41P300_19829295_ChIP-Seq_ESCs_Human1.79209485
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75297809
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.74747208
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74713100
45FUS_26573619_Chip-Seq_HEK293_Human1.72129216
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.71558484
47* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71119576
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70984185
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69984650
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68489091
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.66343015
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65813397
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.64790873
54RNF2_27304074_Chip-Seq_NSC_Mouse1.63388414
55TAF15_26573619_Chip-Seq_HEK293_Human1.63275690
56SMAD4_21799915_ChIP-Seq_A2780_Human1.60831110
57AR_21572438_ChIP-Seq_LNCaP_Human1.60548553
58ERA_21632823_ChIP-Seq_H3396_Human1.59318534
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.59162890
60DROSHA_22980978_ChIP-Seq_HELA_Human1.58281614
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.53666982
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.53378869
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53288803
64HNFA_21074721_ChIP-Seq_CACO-2_Human1.52771784
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47282348
66RAC3_21632823_ChIP-Seq_H3396_Human1.47255226
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46804362
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46542847
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46467571
70EWS_26573619_Chip-Seq_HEK293_Human1.45159199
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44730329
72* LXR_22158963_ChIP-Seq_LIVER_Mouse1.44654314
73NFYB_21822215_ChIP-Seq_K562_Human1.44420118
74PHF8_20622853_ChIP-Seq_HELA_Human1.43612635
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.42868364
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41983587
77NANOG_20526341_ChIP-Seq_ESCs_Human1.41027267
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.40616416
79TBL1_22424771_ChIP-Seq_293T_Human1.40542316
80ETV1_20927104_ChIP-Seq_GIST48_Human1.39816421
81WDR5_24793694_ChIP-Seq_LNCAP_Human1.39400058
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.37755803
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37753624
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37753624
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37320945
86CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36465079
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35170158
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35063597
89TP53_18474530_ChIP-ChIP_U2OS_Human1.33188566
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32968534
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32504212
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32293606
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30896462
94REST_21632747_ChIP-Seq_MESCs_Mouse1.30443869
95NFYA_21822215_ChIP-Seq_K562_Human1.28486445
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28478982
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27928173
98RBPJ_21746931_ChIP-Seq_IB4_Human1.27704582
99MYC_19829295_ChIP-Seq_ESCs_Human1.27055244
100OCT4_20526341_ChIP-Seq_ESCs_Human1.27007404
101AR_25329375_ChIP-Seq_VCAP_Human1.26749947
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26182668
103* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24657871
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24517698
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23426896
106TAF2_19829295_ChIP-Seq_ESCs_Human1.23285164
107GATA6_21074721_ChIP-Seq_CACO-2_Human1.23033308
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.22778036
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.22622357
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21878876
111GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.21736830
112* STAT3_23295773_ChIP-Seq_U87_Human1.21451508
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20971016
114P53_22387025_ChIP-Seq_ESCs_Mouse1.19573212
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.16026769
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14749361
117* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14289402
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.14236987
119RUNX2_22187159_ChIP-Seq_PCA_Human1.13731258
120VDR_22108803_ChIP-Seq_LS180_Human1.13572332
121* ARNT_22903824_ChIP-Seq_MCF-7_Human1.13363185
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.12536273
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12456606
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12176487
125TCF4_23295773_ChIP-Seq_U87_Human1.12107798
126* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11945331
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11294249
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11280985
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10442829
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10377991
131ZNF274_21170338_ChIP-Seq_K562_Hela1.10151532
132* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09417393
133CEBPB_22108803_ChIP-Seq_LS180_Human1.09230397
134SALL1_21062744_ChIP-ChIP_HESCs_Human1.09044130
135IRF1_19129219_ChIP-ChIP_H3396_Human1.08869873
136SMAD3_21741376_ChIP-Seq_ESCs_Human1.08413995
137* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07356553
138CMYC_18555785_Chip-Seq_ESCs_Mouse1.07280100
139SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07142819
140GATA3_21878914_ChIP-Seq_MCF-7_Human1.07033729
141STAT3_18555785_Chip-Seq_ESCs_Mouse1.06647895
142TP53_20018659_ChIP-ChIP_R1E_Mouse1.06360061
143NCOR_22424771_ChIP-Seq_293T_Human1.06339961
144SMC4_20622854_ChIP-Seq_HELA_Human1.05770783
145* AR_19668381_ChIP-Seq_PC3_Human1.05415390
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04875672
147LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04582879
148SOX2_19829295_ChIP-Seq_ESCs_Human1.03873311
149NANOG_19829295_ChIP-Seq_ESCs_Human1.03873311
150FOXH1_21741376_ChIP-Seq_EPCs_Human1.03283060
151* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03001969
152VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02603052
153AHR_22903824_ChIP-Seq_MCF-7_Human1.02340540
154GF1_26923725_Chip-Seq_HPCs_Mouse1.01539047
155FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00902766
156CTCF_27219007_Chip-Seq_Bcells_Human1.00723503
157OCT1_27270436_Chip-Seq_PROSTATE_Human1.00352811
158CTCF_20526341_ChIP-Seq_ESCs_Human1.00046935
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.99573513
160ELF1_20517297_ChIP-Seq_JURKAT_Human0.99394508
161MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99325983
162TCF4_22108803_ChIP-Seq_LS180_Human0.97689379
163P300_27268052_Chip-Seq_Bcells_Human0.97569971
164E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97563612
165SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95972177
166ERG_20517297_ChIP-Seq_VCAP_Human0.95326274
167* RUNX_20019798_ChIP-Seq_JUKART_Human0.94933705
168TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92257774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.30759368
2MP0005410_abnormal_fertilization5.65952041
3MP0002138_abnormal_hepatobiliary_system4.55201467
4MP0009697_abnormal_copulation4.50514355
5MP0005360_urolithiasis4.29979845
6MP0003122_maternal_imprinting3.72388711
7MP0005085_abnormal_gallbladder_physiolo3.38891872
8MP0000566_synostosis3.30261630
9MP0005365_abnormal_bile_salt3.29421071
10MP0003195_calcinosis3.22582207
11MP0003646_muscle_fatigue3.12833042
12MP0003718_maternal_effect3.06973196
13MP0003868_abnormal_feces_composition3.01066246
14MP0001188_hyperpigmentation2.79645561
15MP0006292_abnormal_olfactory_placode2.60096105
16MP0003252_abnormal_bile_duct2.57574361
17MP0005670_abnormal_white_adipose2.57441914
18MP0003698_abnormal_male_reproductive2.55471568
19MP0001666_abnormal_nutrient_absorption2.52226483
20MP0003121_genomic_imprinting2.49922313
21MP0002876_abnormal_thyroid_physiology2.40716668
22MP0001929_abnormal_gametogenesis2.40130189
23MP0005503_abnormal_tendon_morphology2.33582919
24MP0002938_white_spotting2.32124642
25MP0004859_abnormal_synaptic_plasticity2.32031267
26MP0008875_abnormal_xenobiotic_pharmacok2.30536756
27MP0000049_abnormal_middle_ear2.27661839
28MP0002249_abnormal_larynx_morphology2.16474003
29MP0003787_abnormal_imprinting2.09509549
30MP0005171_absent_coat_pigmentation1.97722217
31MP0009250_abnormal_appendicular_skeleto1.97022144
32MP0002102_abnormal_ear_morphology1.87573428
33MP0003941_abnormal_skin_development1.87443766
34MP0000537_abnormal_urethra_morphology1.84088183
35MP0000678_abnormal_parathyroid_gland1.81569791
36MP0003385_abnormal_body_wall1.75896899
37MP0000026_abnormal_inner_ear1.69600700
38MP0003942_abnormal_urinary_system1.63699066
39MP0002161_abnormal_fertility/fecundity1.62312574
40MP0010030_abnormal_orbit_morphology1.58337815
41MP0001764_abnormal_homeostasis1.57163002
42MP0000462_abnormal_digestive_system1.56516441
43MP0000762_abnormal_tongue_morphology1.56182872
44MP0003123_paternal_imprinting1.56121291
45MP0005248_abnormal_Harderian_gland1.54318317
46MP0000516_abnormal_urinary_system1.53012713
47MP0005367_renal/urinary_system_phenotyp1.53012713
48MP0003755_abnormal_palate_morphology1.50373122
49MP0000778_abnormal_nervous_system1.48872954
50MP0004381_abnormal_hair_follicle1.47558085
51MP0003880_abnormal_central_pattern1.47102551
52MP0002116_abnormal_craniofacial_bone1.46648326
53MP0010386_abnormal_urinary_bladder1.46218523
54MP0005332_abnormal_amino_acid1.45349905
55MP0003937_abnormal_limbs/digits/tail_de1.45235535
56MP0005645_abnormal_hypothalamus_physiol1.44919006
57MP0005409_darkened_coat_color1.44153290
58MP0002735_abnormal_chemical_nociception1.43375319
59MP0005395_other_phenotype1.43338887
60MP0005646_abnormal_pituitary_gland1.41729939
61MP0010329_abnormal_lipoprotein_level1.40972690
62MP0001486_abnormal_startle_reflex1.39708209
63MP0003635_abnormal_synaptic_transmissio1.38984451
64MP0002282_abnormal_trachea_morphology1.38453653
65MP0001968_abnormal_touch/_nociception1.36929823
66MP0002751_abnormal_autonomic_nervous1.36059268
67MP0002932_abnormal_joint_morphology1.35468236
68MP0002234_abnormal_pharynx_morphology1.35450667
69MP0003938_abnormal_ear_development1.35384346
70MP0003879_abnormal_hair_cell1.34870048
71MP0003283_abnormal_digestive_organ1.31902413
72MP0002109_abnormal_limb_morphology1.28922745
73MP0003935_abnormal_craniofacial_develop1.28346929
74MP0000631_abnormal_neuroendocrine_gland1.28155638
75MP0002184_abnormal_innervation1.27053192
76MP0009840_abnormal_foam_cell1.26231250
77MP0008877_abnormal_DNA_methylation1.26205885
78MP0004233_abnormal_muscle_weight1.25257359
79MP0001963_abnormal_hearing_physiology1.24165560
80MP0002233_abnormal_nose_morphology1.23880595
81MP0002177_abnormal_outer_ear1.23514625
82MP0002210_abnormal_sex_determination1.21987480
83MP0001986_abnormal_taste_sensitivity1.17771300
84MP0002557_abnormal_social/conspecific_i1.15947887
85MP0009745_abnormal_behavioral_response1.15565975
86MP0005508_abnormal_skeleton_morphology1.15541547
87MP0003959_abnormal_lean_body1.15235580
88MP0003315_abnormal_perineum_morphology1.15169668
89MP0002736_abnormal_nociception_after1.15095136
90MP0002572_abnormal_emotion/affect_behav1.14967452
91MP0006276_abnormal_autonomic_nervous1.12461327
92MP0001661_extended_life_span1.12106168
93MP0002063_abnormal_learning/memory/cond1.10675028
94MP0001270_distended_abdomen1.09574700
95MP0009053_abnormal_anal_canal1.08765629
96MP0003878_abnormal_ear_physiology1.07898138
97MP0005377_hearing/vestibular/ear_phenot1.07898138
98MP0004134_abnormal_chest_morphology1.07038371
99MP0000534_abnormal_ureter_morphology1.06780734
100MP0000163_abnormal_cartilage_morphology1.06628206
101MP0000653_abnormal_sex_gland1.05167106
102MP0004272_abnormal_basement_membrane1.03440809
103MP0001293_anophthalmia1.03300289
104MP0002118_abnormal_lipid_homeostasis1.00298577
105MP0002067_abnormal_sensory_capabilities0.98708961
106MP0005408_hypopigmentation0.97589068
107MP0001501_abnormal_sleep_pattern0.97499349
108MP0004742_abnormal_vestibular_system0.96659501
109MP0000432_abnormal_head_morphology0.95853834
110MP0005187_abnormal_penis_morphology0.95577132
111MP0002132_abnormal_respiratory_system0.95422064
112MP0005423_abnormal_somatic_nervous0.95346235
113MP0002115_abnormal_skeleton_extremities0.94803321
114MP0005257_abnormal_intraocular_pressure0.94620361
115MP0003119_abnormal_digestive_system0.93884554
116MP0001346_abnormal_lacrimal_gland0.93665497
117MP0003115_abnormal_respiratory_system0.93516856
118MP0002638_abnormal_pupillary_reflex0.92750257
119MP0001145_abnormal_male_reproductive0.92436259
120MP0000681_abnormal_thyroid_gland0.90819169
121MP0008961_abnormal_basal_metabolism0.89719053
122MP0001502_abnormal_circadian_rhythm0.88866553
123MP0004036_abnormal_muscle_relaxation0.87612726
124MP0000538_abnormal_urinary_bladder0.86704586
125MP0000372_irregular_coat_pigmentation0.85807971
126MP0002114_abnormal_axial_skeleton0.85612215
127MP0005266_abnormal_metabolism0.85116055
128MP0000579_abnormal_nail_morphology0.84970438
129MP0003806_abnormal_nucleotide_metabolis0.84845024
130MP0002277_abnormal_respiratory_mucosa0.83163379
131MP0001286_abnormal_eye_development0.82326572
132MP0005075_abnormal_melanosome_morpholog0.81909777
133MP0002064_seizures0.81459658
134MP0002822_catalepsy0.81334392
135MP0000609_abnormal_liver_physiology0.80878064
136MP0000428_abnormal_craniofacial_morphol0.80083619
137MP0001485_abnormal_pinna_reflex0.78683577
138MP0004133_heterotaxia0.78460097
139MP0002163_abnormal_gland_morphology0.78202995
140MP0000751_myopathy0.77778487
141MP0000569_abnormal_digit_pigmentation0.77585667
142MP0005551_abnormal_eye_electrophysiolog0.76677133
143MP0003136_yellow_coat_color0.76268373
144MP0002113_abnormal_skeleton_development0.75994949
145MP0000613_abnormal_salivary_gland0.74847411
146MP0003699_abnormal_female_reproductive0.74712859
147MP0008789_abnormal_olfactory_epithelium0.73890702
148MP0002272_abnormal_nervous_system0.73587166
149MP0009115_abnormal_fat_cell0.72391506
150MP0002127_abnormal_cardiovascular_syste0.68878932
151MP0002928_abnormal_bile_duct0.64489830
152MP0001348_abnormal_lacrimal_gland0.63552019
153MP0000733_abnormal_muscle_development0.62635423
154MP0008057_abnormal_DNA_replication0.62553151
155MP0004019_abnormal_vitamin_homeostasis0.58729253
156MP0003763_abnormal_thymus_physiology0.57365643
157MP0005376_homeostasis/metabolism_phenot0.56621010
158MP0010368_abnormal_lymphatic_system0.53431440
159MP0002971_abnormal_brown_adipose0.52775217
160MP0003890_abnormal_embryonic-extraembry0.51065652
161MP0001984_abnormal_olfaction0.48662161
162MP0005636_abnormal_mineral_homeostasis0.48026159
163MP0000470_abnormal_stomach_morphology0.46377899
164MP0005319_abnormal_enzyme/_coenzyme0.45992941
165MP0003638_abnormal_response/metabolism_0.45003033
166MP0005647_abnormal_sex_gland0.44118805
167MP0009643_abnormal_urine_homeostasis0.43490700
168MP0002229_neurodegeneration0.43469062
169MP0010094_abnormal_chromosome_stability0.43249916
170MP0005499_abnormal_olfactory_system0.42807030
171MP0005394_taste/olfaction_phenotype0.42807030
172MP0002269_muscular_atrophy0.42391200
173MP0005451_abnormal_body_composition0.42318955
174MP0001324_abnormal_eye_pigmentation0.42006544
175MP0005535_abnormal_body_temperature0.41745919

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.68526391
2Deep venous thrombosis (HP:0002625)5.48533193
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.96357455
4Prolonged partial thromboplastin time (HP:0003645)4.39293733
5Abnormal biliary tract physiology (HP:0012439)4.17989080
6Bile duct proliferation (HP:0001408)4.17989080
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.17935990
8Absent/shortened dynein arms (HP:0200106)4.17935990
9Abnormality of pyrimidine metabolism (HP:0004353)4.06724103
10Abnormal respiratory motile cilium physiology (HP:0012261)3.93692851
11Abnormal ciliary motility (HP:0012262)3.92236680
12Severe visual impairment (HP:0001141)3.84440467
13Midline defect of the nose (HP:0004122)3.81006596
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.67764641
15Hypobetalipoproteinemia (HP:0003563)3.65643660
16Impulsivity (HP:0100710)3.56543197
17Hypoalphalipoproteinemia (HP:0003233)3.38574218
18Generalized aminoaciduria (HP:0002909)3.27265598
19Hypoplasia of the thymus (HP:0000778)3.23033885
20Osteomalacia (HP:0002749)3.22775214
21Hypolipoproteinemia (HP:0010981)3.16526749
22Reduced antithrombin III activity (HP:0001976)3.15727485
23Rhinitis (HP:0012384)3.14443364
24Short 4th metacarpal (HP:0010044)3.12455262
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.12455262
26Intrahepatic cholestasis (HP:0001406)2.99734336
27Absent eyebrow (HP:0002223)2.95320735
28Asymmetric septal hypertrophy (HP:0001670)2.85925740
29Lip pit (HP:0100267)2.85654144
30Morphological abnormality of the middle ear (HP:0008609)2.84813547
31Abnormal respiratory epithelium morphology (HP:0012253)2.84347315
32Abnormal respiratory motile cilium morphology (HP:0005938)2.84347315
33Hyperkalemia (HP:0002153)2.80604889
34Complement deficiency (HP:0004431)2.78324011
35Attenuation of retinal blood vessels (HP:0007843)2.75559854
36Febrile seizures (HP:0002373)2.70285238
37Abnormality of the parietal bone (HP:0002696)2.66477575
38Truncal obesity (HP:0001956)2.65063636
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62492475
40Tubular atrophy (HP:0000092)2.62295804
41Cutaneous finger syndactyly (HP:0010554)2.60370705
42Potter facies (HP:0002009)2.59864535
43Facial shape deformation (HP:0011334)2.59864535
44Focal motor seizures (HP:0011153)2.53731334
45Azoospermia (HP:0000027)2.52394496
46Abnormality of nucleobase metabolism (HP:0010932)2.50463695
47Abnormality of the fingertips (HP:0001211)2.46816112
48Follicular hyperkeratosis (HP:0007502)2.45839931
49Renal duplication (HP:0000075)2.43217566
50Infertility (HP:0000789)2.41771624
51Nasal polyposis (HP:0100582)2.39779505
52Hypophosphatemic rickets (HP:0004912)2.39645035
53Bony spicule pigmentary retinopathy (HP:0007737)2.37698573
54Aplasia cutis congenita (HP:0001057)2.36472226
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36008217
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35175455
57Abnormality of the renal cortex (HP:0011035)2.34917172
58Progressive cerebellar ataxia (HP:0002073)2.32788145
59Hyperlipoproteinemia (HP:0010980)2.32238678
60Asymmetry of the thorax (HP:0001555)2.31802218
61Postural instability (HP:0002172)2.29940126
62Aplasia/Hypoplasia of the earlobes (HP:0009906)2.26068601
63Cutaneous syndactyly (HP:0012725)2.24775738
64Absent eyelashes (HP:0000561)2.24491761
65Self-mutilation (HP:0000742)2.23896300
66Abnormality of the nasolacrimal system (HP:0000614)2.23783406
67Hepatoblastoma (HP:0002884)2.23735304
68Joint hemorrhage (HP:0005261)2.23455393
69Polydipsia (HP:0001959)2.23324027
70Abnormal drinking behavior (HP:0030082)2.23324027
71Thyroiditis (HP:0100646)2.22718575
72Mesomelia (HP:0003027)2.22126250
73Abnormality of the right ventricle (HP:0001707)2.21576613
74Abnormality of the 4th metacarpal (HP:0010012)2.21455603
75Tubulointerstitial abnormality (HP:0001969)2.21042578
76Occipital encephalocele (HP:0002085)2.20267865
77Renal dysplasia (HP:0000110)2.19586483
78Abnormality of the renal collecting system (HP:0004742)2.19040861
79Narrow nasal bridge (HP:0000446)2.18424607
80Chromsome breakage (HP:0040012)2.17350009
81Short middle phalanx of the 5th finger (HP:0004220)2.16689675
82Stage 5 chronic kidney disease (HP:0003774)2.16079252
83Abnormal urine output (HP:0012590)2.15757301
84Resting tremor (HP:0002322)2.13904246
85Male infertility (HP:0003251)2.13123302
86Type II lissencephaly (HP:0007260)2.09685358
87Abnormal spermatogenesis (HP:0008669)2.07943225
88Chronic bronchitis (HP:0004469)2.07837014
89Optic nerve hypoplasia (HP:0000609)2.07093535
90Duplicated collecting system (HP:0000081)2.06310843
91Rickets (HP:0002748)2.03450130
92Fair hair (HP:0002286)2.03319901
93Abnormality of the lacrimal duct (HP:0011481)2.02927390
94Abnormality of sulfur amino acid metabolism (HP:0004339)2.02272214
95Absent speech (HP:0001344)2.02220967
96Ectopic kidney (HP:0000086)2.02149126
97Hypoventilation (HP:0002791)2.01791573
98Aplasia/Hypoplasia of the uvula (HP:0010293)2.01371094
99Vitreoretinal degeneration (HP:0000655)1.95034894
100Atrophic scars (HP:0001075)1.94010666
101Nephritis (HP:0000123)1.92729027
102True hermaphroditism (HP:0010459)1.92460186
103Abnormality of macular pigmentation (HP:0008002)1.92006520
104Glycosuria (HP:0003076)1.91377143
105Abnormality of urine glucose concentration (HP:0011016)1.91377143
106Fetal akinesia sequence (HP:0001989)1.90831407
107Periauricular skin pits (HP:0100277)1.90479571
108Preauricular pit (HP:0004467)1.90479571
109Mild short stature (HP:0003502)1.90417633
110Protruding tongue (HP:0010808)1.89663511
111Bifid tongue (HP:0010297)1.89603762
112Conjugated hyperbilirubinemia (HP:0002908)1.88364407
113Abnormal hair whorl (HP:0010721)1.87720913
114Increased number of teeth (HP:0011069)1.86566065
115Amelogenesis imperfecta (HP:0000705)1.86562826
116Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86517661
117Popliteal pterygium (HP:0009756)1.86258439
118Abnormality of glutamine family amino acid metabolism (HP:0010902)1.83665303
119Septo-optic dysplasia (HP:0100842)1.83326804
120Nephronophthisis (HP:0000090)1.83106934
121Hypergonadotropic hypogonadism (HP:0000815)1.81822036
122Flat cornea (HP:0007720)1.81613781
123Epileptic encephalopathy (HP:0200134)1.80893922
124Abnormality of the pubic bones (HP:0003172)1.80644421
125Congenital sensorineural hearing impairment (HP:0008527)1.80633759
126Abnormal gallbladder physiology (HP:0012438)1.80603134
127Cholecystitis (HP:0001082)1.80603134
128Bell-shaped thorax (HP:0001591)1.80076133
129Portal hypertension (HP:0001409)1.79872173
130Enlarged kidneys (HP:0000105)1.79680747
131Tented upper lip vermilion (HP:0010804)1.79561099
132Abnormality of purine metabolism (HP:0004352)1.78844341
133Abnormality of complement system (HP:0005339)1.78450254
134Glomerulonephritis (HP:0000099)1.78370727
135Anophthalmia (HP:0000528)1.78129677
136Pulmonary artery stenosis (HP:0004415)1.77240174
137Tubulointerstitial nephritis (HP:0001970)1.75700847
138Pancreatic cysts (HP:0001737)1.74588746
139Myelomeningocele (HP:0002475)1.74525860
140Abnormality of the hepatic vasculature (HP:0006707)1.74083906
141Abnormality of incisor morphology (HP:0011063)1.74065842
142Abnormality of renal excretion (HP:0011036)1.73608738
143Bulbous nose (HP:0000414)1.73162809
144Polyuria (HP:0000103)1.72775710
145Embryonal renal neoplasm (HP:0011794)1.72236526
146Skin pits (HP:0100276)1.72169862
147Renovascular hypertension (HP:0100817)1.71643873
148Cone-rod dystrophy (HP:0000548)1.71024931
149Omphalocele (HP:0001539)1.70748848
150Meckel diverticulum (HP:0002245)1.69654571
151Abnormality of the renal medulla (HP:0100957)1.67948014
152Intellectual disability, moderate (HP:0002342)1.65697022
153Microglossia (HP:0000171)1.64928553
154Abnormality of the phalanges of the hallux (HP:0010057)1.64279979
155Tracheomalacia (HP:0002779)1.63939547
156Epiphyseal dysplasia (HP:0002656)1.63821659
157Bilateral microphthalmos (HP:0007633)1.62599041
158White forelock (HP:0002211)1.61470580
159Nephroblastoma (Wilms tumor) (HP:0002667)1.60796641
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60195131
161Chronic hepatic failure (HP:0100626)1.59615256
162Anterior segment dysgenesis (HP:0007700)1.57797282
163Pancreatic fibrosis (HP:0100732)1.57288143
164Abnormality of the ileum (HP:0001549)1.56748896
165Renal hypoplasia (HP:0000089)1.56213294
166Fragile skin (HP:0001030)1.55875934
167Syringomyelia (HP:0003396)1.54799188
168Spinal cord lesions (HP:0100561)1.54799188
169Shallow orbits (HP:0000586)1.54198676
170Trigonocephaly (HP:0000243)1.53459621
171Exotropia (HP:0000577)1.52068554
172Abnormality of the incisor (HP:0000676)1.51875226
173Ectopic anus (HP:0004397)1.51748967
174Severe Myopia (HP:0011003)1.51176091
175Supernumerary ribs (HP:0005815)1.50630488
176Fibular hypoplasia (HP:0003038)1.50506454
177Nasolacrimal duct obstruction (HP:0000579)1.50395550
178Absent hair (HP:0002298)1.49842817
179Postaxial foot polydactyly (HP:0001830)1.49167608
180Patchy hypopigmentation of hair (HP:0011365)1.48798385
181Decreased circulating renin level (HP:0003351)1.48138287
182Hypoplasia of the maxilla (HP:0000327)1.47341688
183Long nose (HP:0003189)1.46624637
184Broad-based gait (HP:0002136)1.45825150
185Bladder diverticulum (HP:0000015)1.45789280
186Abnormality of the carotid arteries (HP:0005344)1.45510926
187Limited hip movement (HP:0008800)1.44997686
188Downturned corners of mouth (HP:0002714)1.44758583
189Micromelia (HP:0002983)1.43521603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.62163835
2CASK4.37459006
3TNIK3.71097580
4SIK33.36255642
5CDK123.25175798
6PIK3CG3.18956203
7NTRK33.14205796
8MAP2K72.98181932
9PNCK2.93006258
10PINK12.68399050
11PRPF4B2.62564364
12MKNK22.60847536
13BRD42.45245856
14NLK2.39015685
15OBSCN2.27670149
16MAPK132.20874465
17EPHB22.20422578
18EPHA32.13075120
19AKT32.06919790
20FRK2.05763988
21INSRR2.00737696
22TLK11.94578039
23EPHA41.89558918
24ZAK1.88032653
25MARK11.83889677
26MAP4K21.78609842
27STK391.72258115
28NTRK21.71257357
29LATS11.66894042
30DDR21.63592370
31ERBB31.59517167
32WNK41.58102897
33CAMK1D1.48034293
34KSR11.45954974
35SGK21.42522131
36MAP3K41.39888873
37MAP3K71.38019007
38SRPK11.37401028
39CDK71.37340791
40MAP3K131.35976738
41EIF2AK21.33476655
42STK38L1.32188610
43MKNK11.31189240
44MAP3K31.27664044
45PLK21.27613652
46MAP3K121.25899877
47CDK31.25224514
48SIK11.23538291
49EEF2K1.20984861
50BMPR1B1.16650272
51YES11.16579861
52STK381.13615705
53CDC71.12472915
54TESK11.11395092
55NUAK11.09234859
56MAP3K21.08208122
57SIK21.04187650
58STK241.04067279
59PRKCE1.01387821
60CDK80.98882158
61DMPK0.95526702
62NEK60.92400409
63PRKCG0.90116954
64PRKD30.87930860
65MUSK0.86838493
66MAPK110.86284238
67PDK10.82491510
68FGFR20.81718494
69MST1R0.81477856
70MARK30.79019295
71RPS6KA50.78666546
72SGK4940.78426048
73SGK2230.78426048
74MAPK150.78216943
75TXK0.77737542
76BCR0.77129851
77MAP3K90.77062360
78TAOK30.77003936
79SGK10.75093782
80CAMK10.74612940
81MYLK0.73248512
82TRPM70.72086332
83CSNK1A1L0.71863508
84MAP3K140.71006594
85PDPK10.70416329
86WNK30.69258663
87DYRK20.69098751
88TAOK20.68977108
89TYRO30.68738700
90STK160.68351431
91CDK90.68155638
92PRKAA20.67187502
93ADRBK20.66917424
94CSNK1G30.66357577
95PRKD20.66330462
96LATS20.65887484
97SGK30.65084258
98CHEK20.64947919
99PRKAA10.64262691
100TIE10.63446958
101DYRK1A0.63256248
102MAP2K20.62636352
103BMPR20.62535728
104MTOR0.62426424
105MARK20.61910083
106AURKA0.61849543
107MAPKAPK30.61437375
108CAMK2A0.59725368
109BRAF0.59284478
110FER0.59119261
111ICK0.57377677
112ACVR1B0.56855997
113CAMK1G0.56746880
114ERBB20.56601395
115RPS6KA60.54454547
116ATR0.54389133
117MINK10.53131400
118TAF10.52519597
119WNK10.51910967
120IRAK10.51826933
121MAP3K100.51674272
122CDK10.50094320
123ADRBK10.46345283
124CDK20.45992378
125MAP2K40.45653632
126PLK30.45590735
127PHKG20.45470904
128PHKG10.45470904
129CLK10.45420323
130RPS6KB10.44622041
131CDC42BPA0.44177158
132PKN10.43431452
133GRK10.42970501
134PRKCQ0.42870775
135PLK10.42826447
136PRKG10.42678742
137CSNK1D0.42045358
138CHEK10.40973269
139CHUK0.40808263
140CAMK40.40633652
141PIK3CA0.40006372
142RPS6KL10.38861677
143RPS6KC10.38861677
144CCNB10.38757280
145CDK40.37934180
146UHMK10.37719213
147VRK10.37498227
148MAPK10.36029194
149CSNK1G20.35767962
150PRKCH0.35700063
151MAPK70.35418966
152CSNK1G10.35168442
153CDK50.32881247
154PRKCZ0.32362970
155GSK3B0.31508224
156FES0.31273862
157ATM0.30054219
158PTK2B0.30037961

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.02400699
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21162267
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.09926564
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07958020
5Retinol metabolism_Homo sapiens_hsa008302.98199516
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.92327460
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.91600623
8Nicotine addiction_Homo sapiens_hsa050332.88587866
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.85464011
10Arginine biosynthesis_Homo sapiens_hsa002202.79422719
11Phenylalanine metabolism_Homo sapiens_hsa003602.75529714
12Caffeine metabolism_Homo sapiens_hsa002322.74686025
13Basal cell carcinoma_Homo sapiens_hsa052172.59411702
14Butanoate metabolism_Homo sapiens_hsa006502.55445178
15Chemical carcinogenesis_Homo sapiens_hsa052042.53520533
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.46664274
17Complement and coagulation cascades_Homo sapiens_hsa046102.44419013
18Drug metabolism - other enzymes_Homo sapiens_hsa009832.20120590
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15916164
20Bile secretion_Homo sapiens_hsa049762.07703789
21Hedgehog signaling pathway_Homo sapiens_hsa043401.99447174
22Circadian entrainment_Homo sapiens_hsa047131.88955885
23Taste transduction_Homo sapiens_hsa047421.87741172
24Axon guidance_Homo sapiens_hsa043601.83308395
25Wnt signaling pathway_Homo sapiens_hsa043101.78141605
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77766163
27Fatty acid degradation_Homo sapiens_hsa000711.75328912
28Linoleic acid metabolism_Homo sapiens_hsa005911.74591356
29Morphine addiction_Homo sapiens_hsa050321.73326980
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70270166
31ABC transporters_Homo sapiens_hsa020101.68406777
32Fatty acid biosynthesis_Homo sapiens_hsa000611.67245368
33Tyrosine metabolism_Homo sapiens_hsa003501.63454882
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63453174
35Glutamatergic synapse_Homo sapiens_hsa047241.61602101
36Systemic lupus erythematosus_Homo sapiens_hsa053221.58577901
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56193857
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54665050
39Insulin secretion_Homo sapiens_hsa049111.54239104
40Tryptophan metabolism_Homo sapiens_hsa003801.54137259
41Peroxisome_Homo sapiens_hsa041461.49218073
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45353255
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43863556
44ECM-receptor interaction_Homo sapiens_hsa045121.41772132
45Serotonergic synapse_Homo sapiens_hsa047261.40824914
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40122166
47Olfactory transduction_Homo sapiens_hsa047401.38878730
48Amphetamine addiction_Homo sapiens_hsa050311.38319524
49Sulfur relay system_Homo sapiens_hsa041221.36003230
50Cocaine addiction_Homo sapiens_hsa050301.36001637
51GABAergic synapse_Homo sapiens_hsa047271.32319691
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31815651
53Arginine and proline metabolism_Homo sapiens_hsa003301.31206044
54Melanogenesis_Homo sapiens_hsa049161.30887948
55Protein digestion and absorption_Homo sapiens_hsa049741.28648299
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26885517
57beta-Alanine metabolism_Homo sapiens_hsa004101.24497844
58Hippo signaling pathway_Homo sapiens_hsa043901.24206123
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.22575021
60Renin secretion_Homo sapiens_hsa049241.22119719
61Calcium signaling pathway_Homo sapiens_hsa040201.21923317
62Lysine degradation_Homo sapiens_hsa003101.20411271
63PPAR signaling pathway_Homo sapiens_hsa033201.19844047
64Fanconi anemia pathway_Homo sapiens_hsa034601.15894791
65Dilated cardiomyopathy_Homo sapiens_hsa054141.14416262
66Cholinergic synapse_Homo sapiens_hsa047251.13647009
67Dopaminergic synapse_Homo sapiens_hsa047281.13384918
68Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12023372
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10967560
70Long-term potentiation_Homo sapiens_hsa047201.10813298
71cAMP signaling pathway_Homo sapiens_hsa040241.09585866
72Histidine metabolism_Homo sapiens_hsa003401.08613687
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08528346
74One carbon pool by folate_Homo sapiens_hsa006701.07877538
75Long-term depression_Homo sapiens_hsa047301.07692820
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05918050
77Starch and sucrose metabolism_Homo sapiens_hsa005001.05346531
78Propanoate metabolism_Homo sapiens_hsa006401.05343650
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04074968
80cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03451758
81Type II diabetes mellitus_Homo sapiens_hsa049300.98859286
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98231055
83Melanoma_Homo sapiens_hsa052180.97022730
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96378375
85Salivary secretion_Homo sapiens_hsa049700.93724420
86Colorectal cancer_Homo sapiens_hsa052100.92859842
87Oxytocin signaling pathway_Homo sapiens_hsa049210.91449379
88Vitamin B6 metabolism_Homo sapiens_hsa007500.91121512
89Pyruvate metabolism_Homo sapiens_hsa006200.88546862
90Notch signaling pathway_Homo sapiens_hsa043300.87810642
91N-Glycan biosynthesis_Homo sapiens_hsa005100.87669332
92ErbB signaling pathway_Homo sapiens_hsa040120.87623507
93Synaptic vesicle cycle_Homo sapiens_hsa047210.86724012
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86279522
95Fatty acid metabolism_Homo sapiens_hsa012120.86041073
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.85584761
97Endometrial cancer_Homo sapiens_hsa052130.84228662
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83758343
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83621889
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.80086478
101Focal adhesion_Homo sapiens_hsa045100.78880812
102Ras signaling pathway_Homo sapiens_hsa040140.78106885
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.77398596
104Ovarian steroidogenesis_Homo sapiens_hsa049130.76316600
105Circadian rhythm_Homo sapiens_hsa047100.75888140
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75556370
107Gap junction_Homo sapiens_hsa045400.73743183
108Pathways in cancer_Homo sapiens_hsa052000.73557285
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73278120
110Adherens junction_Homo sapiens_hsa045200.72879650
111Biosynthesis of amino acids_Homo sapiens_hsa012300.72540018
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72359732
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71031755
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70971399
115MAPK signaling pathway_Homo sapiens_hsa040100.70280043
116Fat digestion and absorption_Homo sapiens_hsa049750.68500273
117Autoimmune thyroid disease_Homo sapiens_hsa053200.68087619
118Arachidonic acid metabolism_Homo sapiens_hsa005900.66651868
119GnRH signaling pathway_Homo sapiens_hsa049120.64715839
120Alcoholism_Homo sapiens_hsa050340.64039570
121Dorso-ventral axis formation_Homo sapiens_hsa043200.63837497
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63148164
123Non-homologous end-joining_Homo sapiens_hsa034500.62866647
124TGF-beta signaling pathway_Homo sapiens_hsa043500.62813371
125Estrogen signaling pathway_Homo sapiens_hsa049150.62549259
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62457197
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62418295
128Prostate cancer_Homo sapiens_hsa052150.59504811
129MicroRNAs in cancer_Homo sapiens_hsa052060.59034099
130Rap1 signaling pathway_Homo sapiens_hsa040150.59022318
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58627754
132Glioma_Homo sapiens_hsa052140.57928588
133Selenocompound metabolism_Homo sapiens_hsa004500.57015109
134Choline metabolism in cancer_Homo sapiens_hsa052310.55596870
135Type I diabetes mellitus_Homo sapiens_hsa049400.53882031
136Gastric acid secretion_Homo sapiens_hsa049710.53160580
137Phototransduction_Homo sapiens_hsa047440.53088060
138HTLV-I infection_Homo sapiens_hsa051660.52890444
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.51335332
140Glycerolipid metabolism_Homo sapiens_hsa005610.49189259
141Basal transcription factors_Homo sapiens_hsa030220.48751532
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48138011
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47869916
144Sphingolipid metabolism_Homo sapiens_hsa006000.47862588
145Metabolic pathways_Homo sapiens_hsa011000.47749303
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47531448
147Proteoglycans in cancer_Homo sapiens_hsa052050.47173351
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46485992
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.45043964
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44326511
151Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43719566
152Homologous recombination_Homo sapiens_hsa034400.43040073
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42632872
154African trypanosomiasis_Homo sapiens_hsa051430.42625312
155Regulation of autophagy_Homo sapiens_hsa041400.42472477
156RNA transport_Homo sapiens_hsa030130.42408579
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39676279
158Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39193777
159Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39094956
160Adipocytokine signaling pathway_Homo sapiens_hsa049200.36415092
161alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33830139
162Carbon metabolism_Homo sapiens_hsa012000.32645666
163Inositol phosphate metabolism_Homo sapiens_hsa005620.30303133
164Oocyte meiosis_Homo sapiens_hsa041140.29676863
165Glucagon signaling pathway_Homo sapiens_hsa049220.27960651
166Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27617899
167Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24340726
168Cell cycle_Homo sapiens_hsa041100.20438837
169Vitamin digestion and absorption_Homo sapiens_hsa049770.19984205
170Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18802339
171AMPK signaling pathway_Homo sapiens_hsa041520.18520528
172Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17731748
173Viral carcinogenesis_Homo sapiens_hsa052030.16265457
174Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15320785
175Insulin resistance_Homo sapiens_hsa049310.13529631
176Nitrogen metabolism_Homo sapiens_hsa009100.11470115
177Folate biosynthesis_Homo sapiens_hsa007900.10180597
1782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.09857013

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